{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:37:37Z","timestamp":1790861857607,"version":"4.1.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2012,4,8]],"date-time":"2012-04-08T00:00:00Z","timestamp":1333843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1007\/s11064-012-0761-x","type":"journal-article","created":{"date-parts":[[2012,4,8]],"date-time":"2012-04-08T02:14:43Z","timestamp":1333851283000},"page":"1372-1380","source":"Crossref","is-referenced-by-count":26,"title":["Abnormal Gangliosides are Localized in Lipid Rafts in Sanfilippo (MPS3a) Mouse Brain"],"prefix":"10.1007","volume":"37","author":[{"given":"G.","family":"Dawson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Fuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. M.","family":"Helmsley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. J.","family":"Hopwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,4,8]]},"reference":[{"key":"761_CR1","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.1074\/jbc.M805186200","volume":"284","author":"EV Berdyshev","year":"2009","unstructured":"Berdyshev EV, Gorshkova I, Skobeleva A, Bittman R, Lu X, Dudek SM, Mirzapoiazova T, Garcia JG, Natarajan V (2009) FTY720 inhibits ceramide synthases and up-regulates dihydrosphingosine 1-phosphate formation in human lung endothelial cells. J Biol Chem 284:5467\u20135477","journal-title":"J Biol Chem"},{"key":"761_CR2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1586\/14789450.2.2.253","volume":"2","author":"X Han","year":"2005","unstructured":"Han X, Gross RW (2005) Shotgun lipidomics: multi-dimensional mass spectrometric analysis of cellular lipidomes. Expert Rev Proteomics 2:253\u2013264","journal-title":"Expert Rev Proteomics"},{"key":"761_CR3","doi-asserted-by":"crossref","first-page":"14134","DOI":"10.1074\/jbc.M109.076810","volume":"285","author":"J Qin","year":"2010","unstructured":"Qin J, Berdyshev E, Goya J, Natarajan V, Dawson G (2010) Neurons and oligodendrocytes recycle sphingosine-1-phosphate to ceramide; significance for apoptosis and multiple sclerosis. J Biol Chem 285:14134\u201314143","journal-title":"J Biol Chem"},{"key":"761_CR4","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1194\/jlr.M800092-JLR200","volume":"49","author":"LK Hein","year":"2008","unstructured":"Hein LK, Duplock S, Hopwood JJ, Fuller M (2008) Lipid composition of microdomains is altered in a cell model of Gaucher disease. J Lipid Res 49:1725\u20131734","journal-title":"J Lipid Res"},{"key":"761_CR5","doi-asserted-by":"crossref","unstructured":"Kilkus J, Goswami R, Dawson SA, Testai FD, Berdyshev E, Han X, Dawson G (2008) Differential regulation of sphingomyelin synthesis and catabolism in oligodendrocytes and neurons. J Neurochem 106:1745\u20131757. PMCID: PMC2720050","DOI":"10.1111\/j.1471-4159.2008.05490.x"},{"key":"761_CR6","doi-asserted-by":"crossref","first-page":"16090","DOI":"10.1074\/jbc.M807438200","volume":"284","author":"S Lahiri","year":"2009","unstructured":"Lahiri S, Park H, Laviad EL, Lu X, Bittman R, Futerman AH (2009) Ceramide synthesis is modulated by the sphingosine analog FTY720 via a mixture of uncompetitive and noncompetitive inhibition in an Acyl-CoA chain length-dependent manner. J Biol Chem 284:16090\u201316098","journal-title":"J Biol Chem"},{"key":"761_CR7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/glia.20930","volume":"58","author":"L Saadat","year":"2009","unstructured":"Saadat L, Dupree JL, Kilkus J, Han X, Traka M, Proia RL, Dawson G, Popko B (2009) Absence of oligodendroglial glucosylceramide synthesis does not result in CNS myelin abnormalities or alter the dysmyelinating phenotype of CGT-deficient mice. Glia 58:391\u2013398","journal-title":"Glia"},{"key":"761_CR8","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/nm.1876","volume":"14","author":"E Lloyd-Evans","year":"2008","unstructured":"Lloyd-Evans E, Morgan AJ, He X, Smith DA, Elliot-Smith E, Sillence DJ, Churchill GC, Schuchman EH, Galione A, Platt FM (2008) Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium. Nat Med 14:1247\u20131255","journal-title":"Nat Med"},{"key":"761_CR9","doi-asserted-by":"crossref","first-page":"5477","DOI":"10.1073\/pnas.0914309107","volume":"107","author":"AI Rosenbaum","year":"2010","unstructured":"Rosenbaum AI, Zhang G, Warren JD, Maxfield FR (2010) Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells. Proc Natl Acad Sci USA 107:5477\u20135482","journal-title":"Proc Natl Acad Sci USA"},{"key":"761_CR10","doi-asserted-by":"crossref","first-page":"e6951","DOI":"10.1371\/journal.pone.0006951","volume":"4","author":"CD Davidson","year":"2009","unstructured":"Davidson CD, Ali NF, Micsenyi MC, Stephney G, Renault S, Dobrenis K, Ory DS, Vanier MT, Walkley SU (2009) Chronic cyclodextrin treatment of murine Niemann-Pick C disease ameliorates neuronal cholesterol and glycosphingolipid storage and disease progression. PLoS One 4:e6951","journal-title":"PLoS One"},{"key":"761_CR11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/10084","volume":"1","author":"T Kobayashi","year":"1999","unstructured":"Kobayashi T, Beuchat MH, Lindsay M, Frias S, Palmiter RD, Sakuraba H, Parton RG, Gruenberg J (1999) Nat Cell Biol 1:113\u2013118","journal-title":"Nat Cell Biol"},{"key":"761_CR12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/jnr.10549","volume":"72","author":"J Kilkus","year":"2003","unstructured":"Kilkus J, Goswami R, Testai FD, Dawson G (2003) Ceramide in rafts (detergent-insoluble fraction) mediates cell death in neurotumor cell lines. J Neurosci Res 72:62\u201375","journal-title":"J Neurosci Res"},{"key":"761_CR13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/cne.20355","volume":"480","author":"R McGlynn","year":"2004","unstructured":"McGlynn R, Dobrenis K, Walkley SU (2004) Differential subcellular localization of cholesterol, gangliosides, and glycosaminoglycans in murine models of mucopolysaccharide storage disorders. J Comp Neurol 480:415\u2013426","journal-title":"J Comp Neurol"},{"key":"761_CR14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2006.05.079","volume":"1104","author":"AC Crawley","year":"2006","unstructured":"Crawley AC, Gliddon BL, Auclair D, Brodie SL, Hirte C, King BM, Fuller M, Hemsley KM, Hopwood JJ (2006) Characterization of a C57BL\/6 congenic mouse strain of mucopolysaccharidosis type IIIA. Brain Res 1104:1\u201317","journal-title":"Brain Res"},{"key":"761_CR15","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.expneurol.2010.07.024","volume":"225","author":"AA Lau","year":"2010","unstructured":"Lau AA, Hannouche H, Rozaklis T, Hassiotis S, Hopwood JJ, Hemsley KM (2010) Allogeneic stem cell transplantation does not improve neurological deficits in mucopolysaccharidosis type IIIA mice. Exp Neurol 225:445\u2013454","journal-title":"Exp Neurol"},{"key":"761_CR16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.gene.2011.09.004","volume":"491","author":"AA Lau","year":"2012","unstructured":"Lau AA, Rozaklis T, Ibanes S, Luck AJ, Beard H, Hassiotis S, Mazouni K, Hopwood JJ, Kremer EJ, Hemsley KM (2012) Helper-dependent canine adenovirus vector-mediated transgene expression in a neurodegenerative lysosomal storage disorder. Gene 491:53\u201357","journal-title":"Gene"},{"key":"761_CR17","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0962-8924(00)01847-X","volume":"10","author":"K Simons","year":"2000","unstructured":"Simons K, Gruenberg J (2000) Jamming the endosomal system: lipid rafts and lysosomal storage diseases. Trends Cell Biol 10:459\u2013462","journal-title":"Trends Cell Biol"},{"key":"761_CR18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1477-5956-5-17","volume":"5","author":"H Yu","year":"2007","unstructured":"Yu H, Wakim B, Li M, Halligan B, Tint GS, Patel SB (2007) Quantifying raft proteins in neonatal mouse brain by \u2018tube-gel\u2019 protein digestion label-free shotgun proteomics. Proteome Sci 5:17","journal-title":"Proteome Sci"},{"key":"761_CR19","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1073\/pnas.0631608100","volume":"100","author":"LJ Foster","year":"2003","unstructured":"Foster LJ, DeHoog CL, Mann M (2003) Unbiased quantitative proteomics of lipid Rafts reveals high specificity for signaling factors. Proc Natl Acad Sci USA 100:5813\u20135818","journal-title":"Proc Natl Acad Sci USA"},{"key":"761_CR20","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1471-4159.2009.05948.x","volume":"109","author":"M Maccarrone","year":"2009","unstructured":"Maccarrone M, Centonze D (2009) Lipid rafts regulate 2-arachidonylglycerol metabolism and physiological activity in the striatum. J Neurochem 109:371\u2013381","journal-title":"J Neurochem"},{"key":"761_CR21","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/icb.2008.103","volume":"87","author":"JS Mitchell","year":"2009","unstructured":"Mitchell JS, Brown WS, Woodside DG, Vanderslice P, McIntyre BW (2009) Clustering T-cell GM1 lipid rafts increases cellular resistance to shear on fibronectin through changes in integrin affinity and cytoskeletal dynamics. Immunol Cell Biol 87:324\u2013336","journal-title":"Immunol Cell Biol"},{"key":"761_CR22","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/sj.bjp.0705930","volume":"143","author":"RS Ostrom","year":"2004","unstructured":"Ostrom RS, Insel PA (2004) The evolving role of lipid rafts and caveolae in G protein-coupled receptor signaling: implications for molecular pharmacology. Br J Pharm 143:235\u2013245","journal-title":"Br J Pharm"},{"key":"761_CR23","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/sj.npp.1300697","volume":"30","author":"RJ Donati","year":"2005","unstructured":"Donati RJ, Rasenick MM (2005) Chronic antidepressant treatment prevents accumulation of Gs\u03b1 in cholesterol-rich, plasma membrane domains (Lipid Rafts). Neuropsychopharm 30:1238\u20131245","journal-title":"Neuropsychopharm"},{"key":"761_CR24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1042\/BJ20071043","volume":"411","author":"PJ Meikle","year":"2008","unstructured":"Meikle PJ, Duplock S, Blacklock D, Whitfield PD, Macintosh G, Hopwood JJ, Fuller M (2008) Effect of lysosomal storage on bis(monoacylglycero)phosphate. Biochem J 411:71\u201378","journal-title":"Biochem J"},{"key":"761_CR25","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/00005072-196504000-00012","volume":"24","author":"R Ledeen","year":"1965","unstructured":"Ledeen R, Salsman K, Gonatas J, Taghavy A (1965) Structure comparison of the major monosialogangliosides from brains of normal human, gargoylism, and late infantile systemic lipidosis. J Neuropathol Exp Neurol 24:341\u2013345","journal-title":"J Neuropathol Exp Neurol"},{"key":"761_CR26","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.nbd.2011.04.014","volume":"43","author":"AC Crawly","year":"2011","unstructured":"Crawly AC et al (2011) Enzyme replacement reduces neuropathology in MPSIIIA dogs. Neurobiol Dis 43:422\u2013434","journal-title":"Neurobiol Dis"},{"key":"761_CR27","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/0005-2760(86)90290-0","volume":"876","author":"S Huterer","year":"1986","unstructured":"Huterer S, Wherrett JR (1986) Incorporation of polyunsaturated fatty acids into bis(monoacylglycero)phosphate and other lipids of macrophages and of fibroblasts from control and Niemann-Pick patients. Biochim Biophys Acta 876:318\u2013326","journal-title":"Biochim Biophys Acta"},{"key":"761_CR28","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1388-1981(99)00021-9","volume":"1473","author":"J Heravi","year":"1999","unstructured":"Heravi J, Waite M (1999) Transacylase formation of bis(monoacylglycerol)phosphate. Biochim Biophys Acta 1473:277\u2013286","journal-title":"Biochim Biophys Acta"},{"key":"761_CR29","doi-asserted-by":"crossref","first-page":"10047","DOI":"10.1074\/jbc.M611249200","volume":"282","author":"M Tani","year":"2007","unstructured":"Tani M, Hannun YA (2007) Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization. J Biol Chem 282:10047\u201310056","journal-title":"J Biol Chem"},{"key":"761_CR30","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nature07605","volume":"456","author":"R Kang","year":"2008","unstructured":"Kang R, Wan J, Arstikaitis P, Takahashi H, Huang K, Bailey AO, Thompson JX, Roth AF, Drisdel RC, Mastro R, Green WN, Yates JR 3rd, Davis NG, El-Husseini A (2008) Neural palmitoyl-proteomics reveals dynamic synaptic palmitoylation. Nature 456:904\u2013909","journal-title":"Nature"},{"key":"761_CR31","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1042\/BJ20091344","volume":"427","author":"AA Cole","year":"2010","unstructured":"Cole AA, Dosemeci A, Reese TS (2010) Co-segregation of AMPA receptors with GM1 ganglioside in synaptosomal membrane subfractions. Biochem J 427:535\u2013540","journal-title":"Biochem J"},{"key":"761_CR32","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1515\/BC.2001.059","volume":"382","author":"T Kobayashi","year":"2001","unstructured":"Kobayashi T, Startchev K, Whitney AJ, Gruenberg J (2001) A lipid regulates endosome structure and function. J Biol Chem 382:483\u2013485","journal-title":"J Biol Chem"},{"key":"761_CR33","doi-asserted-by":"crossref","unstructured":"Matsuo H, Chevallier J, Mayran N, Le Blanc I, Ferguson C, Faure J, Blanc NS, Matile S, Dubochet J, Sadoul R, Parton RG, Vilbois F, Gruenberg J (2004) Role of LBPA and Alix in multivesicular liposome formation and endosome organization. Science 303:531\u2013534","DOI":"10.1126\/science.1092425"},{"key":"761_CR34","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1083\/jcb.201003053","volume":"189","author":"C Tam","year":"2010","unstructured":"Tam C, Idone V, Schuchman E, Tabas I, Andrews NA (2010) Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair. J Cell Biol 189:1027\u20131038","journal-title":"J Cell Biol"},{"key":"761_CR35","doi-asserted-by":"crossref","first-page":"22405","DOI":"10.1073\/pnas.0912336106","volume":"106","author":"Y Ohmi","year":"2009","unstructured":"Ohmi Y, Tajima O, Ohkawa Y, Mori A, Sugiura Y, Furukawa K, Furukawa K (2009) Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues. Proc Natl Acad Sci USA 106:22405\u201322410","journal-title":"Proc Natl Acad Sci USA"},{"key":"761_CR36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/0-306-47931-1_12","volume":"36","author":"E Gulbins","year":"2002","unstructured":"Gulbins E, Kolesnick R (2002) Acid sphingomyelinase-derived ceramide signaling in apoptosis. Sub-Cellular Biochem 36:229\u2013244","journal-title":"Sub-Cellular Biochem"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-012-0761-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-012-0761-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-012-0761-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T21:22:00Z","timestamp":1561584120000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-012-0761-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,8]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["761"],"URL":"https:\/\/doi.org\/10.1007\/s11064-012-0761-x","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,8]]}}}