{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T21:15:41Z","timestamp":1776114941524,"version":"3.50.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,3,9]],"date-time":"2013-03-09T00:00:00Z","timestamp":1362787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1007\/s11064-013-1013-4","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T12:07:31Z","timestamp":1362744451000},"page":"1034-1044","source":"Crossref","is-referenced-by-count":66,"title":["Protective Effects of Hesperidin Against Amyloid-\u03b2 (A\u03b2) Induced Neurotoxicity Through the Voltage Dependent Anion Channel 1 (VDAC1)-Mediated Mitochondrial Apoptotic Pathway in PC12 Cells"],"prefix":"10.1007","volume":"38","author":[{"given":"Dong-Mei","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"San-Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Lan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Juan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,3,9]]},"reference":[{"key":"1013_CR1","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1126\/science.1105681","volume":"307","author":"GB Stokin","year":"2005","unstructured":"Stokin GB, Lillo C, Falzone TL, Brusch RG, Rockenstein E, Mount SL, Raman R, Davies P, Masliah E, Williams DS, Goldstein LS (2005) Axonopathy and transport deficits early in the pathogenesis of Alzheimer\u2019s disease. Science 307:1282\u20131288","journal-title":"Science"},{"key":"1013_CR2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","volume":"430","author":"MP Mattson","year":"2004","unstructured":"Mattson MP (2004) Pathways towards and away from Alzheimer\u2019s disease. Nature 430:631\u2013639","journal-title":"Nature"},{"key":"1013_CR3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","volume":"443","author":"MT Lin","year":"2006","unstructured":"Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787\u2013795","journal-title":"Nature"},{"key":"1013_CR4","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3233\/JAD-2006-9202","volume":"9","author":"PI Moreira","year":"2006","unstructured":"Moreira PI, Cardoso SM, Santos MS, Oliveira CR (2006) The key role of mitochondria in Alzheimer\u2019s disease. J Alzheimers Dis 9:101\u2013110","journal-title":"J Alzheimers Dis"},{"key":"1013_CR5","doi-asserted-by":"crossref","first-page":"e34929","DOI":"10.1371\/journal.pone.0034929","volume":"7","author":"MY Cha","year":"2012","unstructured":"Cha MY, Han SH, Son SM, Hong HS, Choi YJ, Byun J, Mook-Jung I (2012) Mitochondria-specific accumulation of amyloid beta induces mitochondrial dysfunction leading to apoptotic cell death. PLoS ONE 7:e34929","journal-title":"PLoS ONE"},{"key":"1013_CR6","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1016\/j.bpj.2008.11.056","volume":"96","author":"P Picone","year":"2009","unstructured":"Picone P, Carrotta R, Montana G, Nobile MR, San Biagio PL, Di Carlo M (2009) Abeta oligomers and fibrillar aggregates induce different apoptotic pathways in LAN5 neuroblastoma cell cultures. Biophys J 96:4200\u20134211","journal-title":"Biophys J"},{"key":"1013_CR7","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1093\/hmg\/dds360","volume":"21","author":"M Manczak","year":"2012","unstructured":"Manczak M, Reddy PH (2012) Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer\u2019s disease. Hum Mol Genet 21:5131\u20135146","journal-title":"Hum Mol Genet"},{"key":"1013_CR8","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1002\/jcb.23062","volume":"112","author":"R Ren","year":"2011","unstructured":"Ren R, Zhang Y, Li B, Wu Y (2011) Effect of beta-amyloid (25\u201335) on mitochondrial function and expression of mitochondrial permeability transition pore proteins in rat hippocampal neurons. J Cell Biochem 112:1450\u20131457","journal-title":"J Cell Biochem"},{"key":"1013_CR9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3233\/JAD-2010-100966","volume":"23","author":"M Cuadrado-Tejedor","year":"2011","unstructured":"Cuadrado-Tejedor M, Vilarino M, Cabodevilla F, Del Rio J, Frechilla D, Perez-Mediavilla A (2011) Enhanced expression of the voltage-dependent anion channel 1 (VDAC1) in Alzheimer\u2019s disease transgenic mice: an insight into the pathogenic effects of amyloid-beta. J Alzheimers Dis 23:195\u2013206","journal-title":"J Alzheimers Dis"},{"key":"1013_CR10","first-page":"709","volume":"40","author":"EM Galati","year":"1994","unstructured":"Galati EM, Monforte MT, Kirjavainen S, Forestieri AM, Trovato A, Tripodo MM (1994) Biological effects of hesperidin, a citrus flavonoid. (Note I): antiinflammatory and analgesic activity. Farmaco 40:709\u2013712","journal-title":"Farmaco"},{"key":"1013_CR11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.plantsci.2012.07.014","volume":"196","author":"G Agati","year":"2012","unstructured":"Agati G, Azzarello E, Pollastri S, Tattini M (2012) Flavonoids as antioxidants in plants: location and functional significance. Plant Sci 196:67\u201376","journal-title":"Plant Sci"},{"key":"1013_CR12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.tox.2010.01.012","volume":"278","author":"D Ramful","year":"2010","unstructured":"Ramful D, Bahorun T, Bourdon E, Tarnus E, Aruoma OI (2010) Bioactive phenolics and antioxidant propensity of flavedo extracts of Mauritian citrus fruits: potential prophylactic ingredients for functional foods application. Toxicology 278:75\u201387","journal-title":"Toxicology"},{"key":"1013_CR13","doi-asserted-by":"crossref","first-page":"4757","DOI":"10.1021\/jf0502000","volume":"53","author":"PK Wilmsen","year":"2005","unstructured":"Wilmsen PK, Spada DS, Salvador M (2005) Antioxidant activity of the flavonoid hesperidin in chemical and biological systems. J Agric Food Chem 53:4757\u20134761","journal-title":"J Agric Food Chem"},{"key":"1013_CR14","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1177\/0748233709106624","volume":"25","author":"HM Arafa","year":"2009","unstructured":"Arafa HM, Aly HA, Abd-Ellah MF, El-Refaey HM (2009) Hesperidin attenuates benzo[alpha] pyrene-induced testicular toxicity in rats via regulation of oxidant\/antioxidant balance. Toxicol Ind Health 25:417\u2013427","journal-title":"Toxicol Ind Health"},{"key":"1013_CR15","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.lfs.2008.03.002","volume":"82","author":"EJ Choi","year":"2008","unstructured":"Choi EJ (2008) Antioxidative effects of hesperetin against 7,12-dimethylbenz(a) anthracene-induced oxidative stress in mice. Life Sci 82:1059\u20131064","journal-title":"Life Sci"},{"key":"1013_CR16","doi-asserted-by":"crossref","first-page":"479570","DOI":"10.5402\/2012\/479570","volume":"2012","author":"GL Viswanatha","year":"2012","unstructured":"Viswanatha GL, Shylaja H, Sandeep Rao KS, Santhosh Kumar VR, Jagadeesh M (2012) Hesperidin ameliorates immobilization-stress-induced behavioral and biochemical alterations and mitochondrial dysfunction in mice by modulating nitrergic pathway. ISRN Pharmacol 2012:479570","journal-title":"ISRN Pharmacol"},{"key":"1013_CR17","first-page":"609","volume":"49","author":"V Gaur","year":"2011","unstructured":"Gaur V, Aggarwal A, Kumar A (2011) Possible nitric oxide mechanism in the protective effect of hesperidin against ischemic reperfusion cerebral injury in rats. Indian J Exp Biol 49:609\u2013618","journal-title":"Indian J Exp Biol"},{"key":"1013_CR18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S1734-1140(10)70321-2","volume":"62","author":"V Gaur","year":"2010","unstructured":"Gaur V, Kumar A (2010) Hesperidin pre-treatment attenuates NO-mediated cerebral ischemic reperfusion injury and memory dysfunction. Pharmacol Rep 62:635\u2013648","journal-title":"Pharmacol Rep"},{"key":"1013_CR19","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1002\/mnfr.201100682","volume":"56","author":"SM Huang","year":"2012","unstructured":"Huang SM, Tsai SY, Lin JA, Wu CH, Yen GC (2012) Cytoprotective effects of hesperetin and hesperidin against amyloid beta-induced impairment of glucose transport through downregulation of neuronal autophagy. Mol Nutr Food Res 56:601\u2013609","journal-title":"Mol Nutr Food Res"},{"key":"1013_CR20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.brainres.2009.04.054","volume":"1279","author":"K Chen","year":"2009","unstructured":"Chen K, Zhang Q, Wang J, Liu F, Mi M, Xu H, Chen F, Zeng K (2009) Taurine protects transformed rat retinal ganglion cells from hypoxia-induced apoptosis by preventing mitochondrial dysfunction. Brain Res 1279:131\u2013138","journal-title":"Brain Res"},{"key":"1013_CR21","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ceca.2008.01.007","volume":"44","author":"N Diaz-Prieto","year":"2008","unstructured":"Diaz-Prieto N, Herrera-Peco I, de Diego AM, Ruiz-Nuno A, Gallego-Sandin S, Lopez MG, Garcia AG, Cano-Abad MF (2008) Bcl2 mitigates Ca2+\u00a0entry and mitochondrial Ca2+\u00a0overload through downregulation of L-type Ca2+\u00a0channels in PC12 cells. Cell Calcium 44:339\u2013352","journal-title":"Cell Calcium"},{"key":"1013_CR22","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/382685a0","volume":"382","author":"SD Yan","year":"1996","unstructured":"Yan SD, Chen X, Fu J, Chen M, Zhu H, Roher A, Slattery T, Zhao L, Nagashima M, Morser J, Migheli A, Nawroth P, Stern D, Schmidt AM (1996) RAGE and amyloid-beta peptide neurotoxicity in Alzheimer\u2019s disease. Nature 382:685\u2013691","journal-title":"Nature"},{"key":"1013_CR23","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/0092-8674(93)90312-E","volume":"75","author":"C Haass","year":"1993","unstructured":"Haass C, Selkoe DJ (1993) Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide. Cell 75:1039\u20131042","journal-title":"Cell"},{"key":"1013_CR24","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1749-6632.1996.tb34406.x","volume":"777","author":"A Lorenzo","year":"1996","unstructured":"Lorenzo A, Yankner BA (1996) Amyloid fibril toxicity in Alzheimer\u2019s disease and diabetes. Ann N Y Acad Sci 777:89\u201395","journal-title":"Ann N Y Acad Sci"},{"key":"1013_CR25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0006-8993(91)91553-D","volume":"563","author":"CJ Pike","year":"1991","unstructured":"Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW (1991) In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res 563:311\u2013314","journal-title":"Brain Res"},{"key":"1013_CR26","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/sj.bjp.0706865","volume":"149","author":"C Tohda","year":"2006","unstructured":"Tohda C, Tamura T, Matsuyama S, Komatsu K (2006) Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus. Br J Pharmacol 149:532\u2013541","journal-title":"Br J Pharmacol"},{"key":"1013_CR27","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbadis.2009.07.005","volume":"1802","author":"H Du","year":"2010","unstructured":"Du H, Yan SS (2010) Mitochondrial permeability transition pore in Alzheimer\u2019s disease: cyclophilin D and amyloid beta. Biochim Biophys Acta 1802:198\u2013204","journal-title":"Biochim Biophys Acta"},{"key":"1013_CR28","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.nbd.2008.02.003","volume":"30","author":"E Ferreiro","year":"2008","unstructured":"Ferreiro E, Oliveira CR, Pereira CM (2008) The release of calcium from the endoplasmic reticulum induced by amyloid-beta and prion peptides activates the mitochondrial apoptotic pathway. Neurobiol Dis 30:331\u2013342","journal-title":"Neurobiol Dis"},{"key":"1013_CR29","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10863-008-9147-9","volume":"40","author":"V Shoshan-Barmatz","year":"2008","unstructured":"Shoshan-Barmatz V, Keinan N, Zaid H (2008) Uncovering the role of VDAC in the regulation of cell life and death. J Bioenerg Biomembr 40:183\u2013191","journal-title":"J Bioenerg Biomembr"},{"key":"1013_CR30","doi-asserted-by":"crossref","first-page":"10545","DOI":"10.1158\/0008-5472.CAN-05-1925","volume":"65","author":"JG Pastorino","year":"2005","unstructured":"Pastorino JG, Hoek JB, Shulga N (2005) Activation of glycogen synthase kinase 3beta disrupts the binding of hexokinase II to mitochondria by phosphorylating voltage-dependent anion channel and potentiates chemotherapy-induced cytotoxicity. Cancer Res 65:10545\u201310554","journal-title":"Cancer Res"},{"key":"1013_CR31","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0006-8993(90)91355-K","volume":"533","author":"JY Koh","year":"1990","unstructured":"Koh JY, Yang LL, Cotman CW (1990) Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage. Brain Res 533:315\u2013320","journal-title":"Brain Res"},{"key":"1013_CR32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0014-4886(95)90041-1","volume":"131","author":"ME Harris","year":"1995","unstructured":"Harris ME, Hensley K, Butterfield DA, Leedle RA, Carney JM (1995) Direct evidence of oxidative injury produced by the Alzheimer\u2019s beta-amyloid peptide (1\u201340) in cultured hippocampal neurons. Exp Neurol 131:193\u2013202","journal-title":"Exp Neurol"},{"key":"1013_CR33","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0304-3940(96)13148-7","volume":"218","author":"PS Green","year":"1996","unstructured":"Green PS, Gridley KE, Simpkins JW (1996) Estradiol protects against beta-amyloid (25\u201335)-induced toxicity in SK-N-SH human neuroblastoma cells. Neurosci Lett 218:165\u2013168","journal-title":"Neurosci Lett"},{"key":"1013_CR34","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nm0796-783","volume":"2","author":"AC Alonso","year":"1996","unstructured":"Alonso AC, Grundke-Iqbal I, Iqbal K (1996) Alzheimer\u2019s disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med 2:783\u2013787","journal-title":"Nat Med"},{"key":"1013_CR35","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1016\/j.neurobiolaging.2007.12.005","volume":"30","author":"S Hauptmann","year":"2009","unstructured":"Hauptmann S, Scherping I, Drose S, Brandt U, Schulz KL, Jendrach M, Leuner K, Eckert A, Muller WE (2009) Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice. Neurobiol Aging 30:1574\u20131586","journal-title":"Neurobiol Aging"},{"key":"1013_CR36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molmed.2007.12.002","volume":"14","author":"PH Reddy","year":"2008","unstructured":"Reddy PH, Beal MF (2008) Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer\u2019s disease. Trends Mol Med 14:45\u201353","journal-title":"Trends Mol Med"},{"key":"1013_CR37","doi-asserted-by":"crossref","first-page":"9057","DOI":"10.1523\/JNEUROSCI.1469-06.2006","volume":"26","author":"L Devi","year":"2006","unstructured":"Devi L, Prabhu BM, Galati DF, Avadhani NG, Anandatheerthavarada HK (2006) Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer\u2019s disease brain is associated with mitochondrial dysfunction. J Neurosci 26:9057\u20139068","journal-title":"J Neurosci"},{"key":"1013_CR38","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.pnpbp.2004.12.007","volume":"29","author":"PG Sullivan","year":"2005","unstructured":"Sullivan PG, Brown MR (2005) Mitochondrial aging and dysfunction in Alzheimer\u2019s disease. Prog Neuropsychopharmacol Biol Psychiatry 29:407\u2013410","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"1013_CR39","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/hmg\/ddl066","volume":"15","author":"M Manczak","year":"2006","unstructured":"Manczak M, Anekonda TS, Henson E, Park BS, Quinn J, Reddy PH (2006) Mitochondria are a direct site of A beta accumulation in Alzheimer\u2019s disease neurons: implications for free radical generation and oxidative damage in disease progression. Hum Mol Genet 15:1437\u20131449","journal-title":"Hum Mol Genet"},{"key":"1013_CR40","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1126\/science.1091230","volume":"304","author":"JW Lustbader","year":"2004","unstructured":"Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, Wang N, Caspersen C, Chen X, Pollak S, Chaney M, Trinchese F, Liu S, Gunn-Moore F, Lue LF, Walker DG, Kuppusamy P, Zewier ZL, Arancio O, Stern D, Yan SS, Wu H (2004) ABAD directly links Abeta to mitochondrial toxicity in Alzheimer\u2019s disease. Science 304:448\u2013452","journal-title":"Science"},{"key":"1013_CR41","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.tins.2008.06.005","volume":"31","author":"I Bezprozvanny","year":"2008","unstructured":"Bezprozvanny I, Mattson MP (2008) Neuronal calcium mishandling and the pathogenesis of Alzheimer\u2019s disease. Trends Neurosci 31:454\u2013463","journal-title":"Trends Neurosci"},{"key":"1013_CR42","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3233\/JAD-2009-0951","volume":"16","author":"DH Small","year":"2009","unstructured":"Small DH, Gasperini R, Vincent AJ, Hung AC, Foa L (2009) The role of Abeta-induced calcium dysregulation in the pathogenesis of Alzheimer\u2019s disease. J Alzheimers Dis 16:225\u2013233","journal-title":"J Alzheimers Dis"},{"key":"1013_CR43","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1385\/NMM:4:1-2:21","volume":"4","author":"M Hashimoto","year":"2003","unstructured":"Hashimoto M, Rockenstein E, Crews L, Masliah E (2003) Role of protein aggregation in mitochondrial dysfunction and neurodegeneration in Alzheimer\u2019s and Parkinson\u2019s diseases. Neuromolecular Med 4:21\u201336","journal-title":"Neuromolecular Med"},{"key":"1013_CR44","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.toxlet.2011.10.023","volume":"208","author":"ST Ahmad","year":"2012","unstructured":"Ahmad ST, Arjumand W, Nafees S, Seth A, Ali N, Rashid S, Sultana S (2012) Hesperidin alleviates acetaminophen induced toxicity in Wistar rats by abrogation of oxidative stress, apoptosis and inflammation. Toxicol Lett 208:149\u2013161","journal-title":"Toxicol Lett"},{"key":"1013_CR45","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.fct.2010.12.005","volume":"49","author":"PP Trivedi","year":"2011","unstructured":"Trivedi PP, Tripathi DN, Jena GB (2011) Hesperetin protects testicular toxicity of doxorubicin in rat: role of NFkappaB, p38 and caspase-3. Food Chem Toxicol 49:838\u2013847","journal-title":"Food Chem Toxicol"},{"key":"1013_CR46","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1021\/jf072826r","volume":"56","author":"SL Hwang","year":"2008","unstructured":"Hwang SL, Yen GC (2008) Neuroprotective effects of the citrus flavanones against H2O2-induced cytotoxicity in PC12 cells. J Agric Food Chem 56:859\u2013864","journal-title":"J Agric Food Chem"},{"key":"1013_CR47","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/1522-2683(200101)22:1<172::AID-ELPS172>3.0.CO;2-P","volume":"22","author":"BC Yoo","year":"2001","unstructured":"Yoo BC, Fountoulakis M, Cairns N, Lubec G (2001) Changes of voltage-dependent anion-selective channel proteins VDAC1 and VDAC2 brain levels in patients with Alzheimer\u2019s disease and down syndrome. Electrophoresis 22:172\u2013179","journal-title":"Electrophoresis"},{"key":"1013_CR48","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/sj.cdd.4401599","volume":"12","author":"H Zaid","year":"2005","unstructured":"Zaid H, Abu-Hamad S, Israelson A, Nathan I, Shoshan-Barmatz V (2005) The voltage-dependent anion channel-1 modulates apoptotic cell death. Cell Death Differ 12:751\u2013760","journal-title":"Cell Death Differ"},{"key":"1013_CR49","doi-asserted-by":"crossref","first-page":"e1170","DOI":"10.1371\/journal.pone.0001170","volume":"2","author":"T Ghosh","year":"2007","unstructured":"Ghosh T, Pandey N, Maitra A, Brahmachari SK, Pillai B (2007) A role for voltage-dependent anion channel Vdac1 in polyglutamine-mediated neuronal cell death. PLoS ONE 2:e1170","journal-title":"PLoS ONE"},{"key":"1013_CR50","doi-asserted-by":"crossref","first-page":"13482","DOI":"10.1074\/jbc.M708216200","volume":"283","author":"S Abu-Hamad","year":"2008","unstructured":"Abu-Hamad S, Zaid H, Israelson A, Nahon E, Shoshan-Barmatz V (2008) Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding. J Biol Chem 283:13482\u201313490","journal-title":"J Biol Chem"},{"key":"1013_CR51","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.bbabio.2010.03.003","volume":"1797","author":"V Shoshan-Barmatz","year":"2010","unstructured":"Shoshan-Barmatz V, Keinan N, Abu-Hamad S, Tyomkin D, Aram L (2010) Apoptosis is regulated by the VDAC1\u00a0N-terminal region and by VDAC oligomerization: release of cytochrome c, AIF and Smac\/Diablo. Biochim Biophys Acta 1797:1281\u20131291","journal-title":"Biochim Biophys Acta"},{"key":"1013_CR52","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.2174\/0929867033457269","volume":"10","author":"JG Pastorino","year":"2003","unstructured":"Pastorino JG, Hoek JB (2003) Hexokinase II: the integration of energy metabolism and control of apoptosis. Curr Med Chem 10:1535\u20131551","journal-title":"Curr Med Chem"},{"key":"1013_CR53","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/bj20031465","volume":"377","author":"H Azoulay-Zohar","year":"2004","unstructured":"Azoulay-Zohar H, Israelson A, Abu-Hamad S, Shoshan-Barmatz V (2004) In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death. Biochem J 377:347\u2013355","journal-title":"Biochem J"},{"key":"1013_CR54","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.molcel.2004.11.014","volume":"16","author":"N Majewski","year":"2004","unstructured":"Majewski N, Nogueira V, Bhaskar P, Coy PE, Skeen JE, Gottlob K, Chandel NS, Thompson CB, Robey RB, Hay N (2004) Hexokinase\u2013mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Mol Cell 16:819\u2013830","journal-title":"Mol Cell"},{"key":"1013_CR55","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nn.2785","volume":"14","author":"J Jo","year":"2011","unstructured":"Jo J, Whitcomb DJ, Olsen KM, Kerrigan TL, Lo SC, Bru-Mercier G, Dickinson B, Scullion S, Sheng M, Collingridge G, Cho K (2011) Abeta(1\u201342) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3beta. Nat Neurosci 14:545\u2013547","journal-title":"Nat Neurosci"},{"key":"1013_CR56","doi-asserted-by":"crossref","first-page":"18414","DOI":"10.1074\/jbc.M110.209718","volume":"286","author":"S Jimenez","year":"2011","unstructured":"Jimenez S, Torres M, Vizuete M, Sanchez-Varo R, Sanchez-Mejias E, Trujillo-Estrada L, Carmona-Cuenca I, Caballero C, Ruano D, Gutierrez A, Vitorica J (2011) Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3\u00a0K)\/Akt-GSK-3beta pathway in Alzheimer mouse model. J Biol Chem 286:18414\u201318425","journal-title":"J Biol Chem"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-013-1013-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-013-1013-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-013-1013-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T17:18:55Z","timestamp":1562779135000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-013-1013-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,9]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["1013"],"URL":"https:\/\/doi.org\/10.1007\/s11064-013-1013-4","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,9]]}}}