{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T23:14:44Z","timestamp":1783984484477,"version":"3.55.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T00:00:00Z","timestamp":1366675200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1007\/s11064-013-1054-8","type":"journal-article","created":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T15:04:29Z","timestamp":1366643069000},"page":"1543-1552","source":"Crossref","is-referenced-by-count":26,"title":["Early-Life Exposure to Methylmercury in Wildtype and pdr-1\/parkin Knockout C. elegans"],"prefix":"10.1007","volume":"38","author":[{"given":"Ebany J.","family":"Martinez-Finley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudipta","family":"Chakraborty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Slaughter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Aschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,23]]},"reference":[{"issue":"6","key":"1054_CR1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1159\/000026225","volume":"18","author":"JM Gorell","year":"1999","unstructured":"Gorell JM et al (1999) Occupational metal exposures and the risk of Parkinson\u2019s disease. Neuroepidemiology 18(6):303\u2013308","journal-title":"Neuroepidemiology"},{"issue":"6","key":"1054_CR2","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/ajim.1055","volume":"39","author":"KL Kirkey","year":"2001","unstructured":"Kirkey KL et al (2001) Occupational categories at risk for Parkinson\u2019s disease. Am J Ind Med 39(6):564\u2013571","journal-title":"Am J Ind Med"},{"issue":"3","key":"1054_CR3","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000110175","volume":"8","author":"CH Ngim","year":"1989","unstructured":"Ngim CH, Devathasan G (1989) Epidemiologic study on the association between body burden mercury level and idiopathic Parkinson\u2019s disease. Neuroepidemiology 8(3):128\u2013141","journal-title":"Neuroepidemiology"},{"issue":"2","key":"1054_CR4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1600-0404.2007.00991.x","volume":"118","author":"L Wermuth","year":"2008","unstructured":"Wermuth L et al (2008) Prevalence and incidence of Parkinson\u2019s disease in The Faroe Islands. Acta Neurol Scand 118(2):126\u2013131","journal-title":"Acta Neurol Scand"},{"issue":"1\u20132","key":"1054_CR5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(98)01192-5","volume":"823","author":"AI Brooks","year":"1999","unstructured":"Brooks AI et al (1999) Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain Res 823(1\u20132):1\u201310","journal-title":"Brain Res"},{"issue":"2","key":"1054_CR6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/nbdi.2002.0507","volume":"10","author":"AL McCormack","year":"2002","unstructured":"McCormack AL et al (2002) Environmental risk factors and Parkinson\u2019s disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiol Dis 10(2):119\u2013127","journal-title":"Neurobiol Dis"},{"issue":"6676","key":"1054_CR7","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/33416","volume":"392","author":"T Kitada","year":"1998","unstructured":"Kitada T et al (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392(6676):605\u2013608","journal-title":"Nature"},{"issue":"4","key":"1054_CR8","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/00019052-200108000-00008","volume":"14","author":"Y Mizuno","year":"2001","unstructured":"Mizuno Y et al (2001) Parkin and Parkinson\u2019s disease. Curr Opin Neurol 14(4):477\u2013482","journal-title":"Curr Opin Neurol"},{"issue":"22","key":"1054_CR9","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1093\/hmg\/ddi371","volume":"14","author":"W Springer","year":"2005","unstructured":"Springer W et al (2005) A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress. Hum Mol Genet 14(22):3407\u20133423","journal-title":"Hum Mol Genet"},{"issue":"2","key":"1054_CR10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/cne.901630207","volume":"163","author":"J Sulston","year":"1975","unstructured":"Sulston J, Dew M, Brenner S (1975) Dopaminergic neurons in the nematode Caenorhabditis elegans. J Comp Neurol 163(2):215\u2013226","journal-title":"J Comp Neurol"},{"issue":"3","key":"1054_CR11","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0896-6273(00)81199-X","volume":"26","author":"ER Sawin","year":"2000","unstructured":"Sawin ER, Ranganathan R, Horvitz HR (2000) C. elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway. Neuron 26(3):619\u2013631","journal-title":"Neuron"},{"issue":"6","key":"1054_CR12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0024-3205(84)90261-3","volume":"35","author":"J Bartolome","year":"1984","unstructured":"Bartolome J et al (1984) Exposure to methylmercury in utero: effects on biochemical development of catecholamine neurotransmitter systems. Life Sci 35(6):657\u2013670","journal-title":"Life Sci"},{"issue":"5","key":"1054_CR13","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ntt.2009.05.001","volume":"31","author":"A Dreiem","year":"2009","unstructured":"Dreiem A et al (2009) Methylmercury inhibits dopaminergic function in rat pup synaptosomes in an age-dependent manner. Neurotoxicol Teratol 31(5):312\u2013317","journal-title":"Neurotoxicol Teratol"},{"issue":"4","key":"1054_CR14","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.neuro.2008.04.019","volume":"29","author":"MS Petersen","year":"2008","unstructured":"Petersen MS et al (2008) Increased prenatal exposure to methylmercury does not affect the risk of Parkinson\u2019s disease. Neurotoxicology 29(4):591\u2013595","journal-title":"Neurotoxicology"},{"issue":"1","key":"1054_CR15","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.brainres.2006.07.022","volume":"1112","author":"AF Castoldi","year":"2006","unstructured":"Castoldi AF et al (2006) Brain monoaminergic neurotransmission parameters in weanling rats after perinatal exposure to methylmercury and 2,2\u2032,4,4\u2032,5,5\u2032-hexachlorobiphenyl (PCB153). Brain Res 1112(1):91\u201398","journal-title":"Brain Res"},{"issue":"5","key":"1054_CR16","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s00210-003-0716-5","volume":"367","author":"E Dare","year":"2003","unstructured":"Dare E et al (2003) Effects of prenatal exposure to methylmercury on dopamine-mediated locomotor activity and dopamine D2 receptor binding. Naunyn Schmiedebergs Arch Pharmacol 367(5):500\u2013508","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"1","key":"1054_CR17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuro.2008.10.002","volume":"30","author":"M Fujimura","year":"2009","unstructured":"Fujimura M et al (2009) Methylmercury exposure downregulates the expression of Racl and leads to neuritic degeneration and ultimately apoptosis in cerebrocortical neurons. Neurotoxicology 30(1):16\u201322","journal-title":"Neurotoxicology"},{"issue":"2","key":"1054_CR18","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/toxsci\/kfq285","volume":"118","author":"N Vanduyn","year":"2010","unstructured":"Vanduyn N et al (2010) SKN-1\/Nrf2 inhibits dopamine neuron degeneration in a Caenorhabditis elegans model of methylmercury toxicity. Toxicol Sci 118(2):613\u2013624","journal-title":"Toxicol Sci"},{"issue":"4","key":"1054_CR19","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1203\/01.PDR.0000113461.07950.72","volume":"55","author":"RJ Boado","year":"2004","unstructured":"Boado RJ, Li JY, Pardridge WM (2004) Developmental regulation of the rabbit blood-brain barrier LAT1 large neutral amino acid transporter mRNA and protein. Pediatr Res 55(4):557\u2013560","journal-title":"Pediatr Res"},{"issue":"5 Pt 2","key":"1054_CR20","first-page":"R761","volume":"262","author":"LE Kerper","year":"1992","unstructured":"Kerper LE, Ballatori N, Clarkson TW (1992) Methylmercury transport across the blood-brain barrier by an amino acid carrier. Am J Physiol 262(5 Pt 2):R761\u2013R765","journal-title":"Am J Physiol"},{"issue":"4","key":"1054_CR21","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1471-4159.2008.05683.x","volume":"107","author":"Z Yin","year":"2008","unstructured":"Yin Z et al (2008) The methylmercury-l-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter. J Neurochem 107(4):1083\u20131090","journal-title":"J Neurochem"},{"issue":"9","key":"1054_CR22","doi-asserted-by":"crossref","first-page":"7655","DOI":"10.1074\/jbc.M309528200","volume":"279","author":"E Veljkovic","year":"2004","unstructured":"Veljkovic E et al (2004) Functional characterization of Caenorhabditis elegans heteromeric amino acid transporters. J Biol Chem 279(9):7655\u20137662","journal-title":"J Biol Chem"},{"issue":"2","key":"1054_CR23","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.taap.2009.03.013","volume":"240","author":"KJ Helmcke","year":"2009","unstructured":"Helmcke KJ et al (2009) Characterization of the effects of methylmercury on Caenorhabditis elegans. Toxicol Appl Pharmacol 240(2):265\u2013272","journal-title":"Toxicol Appl Pharmacol"},{"issue":"4","key":"1054_CR24","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25(4):402\u2013408","journal-title":"Methods"},{"issue":"3","key":"1054_CR25","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0892-0362(03)00007-2","volume":"25","author":"S Goulet","year":"2003","unstructured":"Goulet S, Dore FY, Mirault ME (2003) Neurobehavioral changes in mice chronically exposed to methylmercury during fetal and early postnatal development. Neurotoxicol Teratol 25(3):335\u2013347","journal-title":"Neurotoxicol Teratol"},{"issue":"1","key":"1054_CR26","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.nbd.2010.05.011","volume":"40","author":"N Saini","year":"2010","unstructured":"Saini N et al (2010) Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways. Neurobiol Dis 40(1):82\u201392","journal-title":"Neurobiol Dis"},{"issue":"18","key":"1054_CR27","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1093\/hmg\/ddg239","volume":"12","author":"JM Itier","year":"2003","unstructured":"Itier JM et al (2003) Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse. Hum Mol Genet 12(18):2277\u20132291","journal-title":"Hum Mol Genet"},{"issue":"2","key":"1054_CR28","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1471-4159.2010.06607.x","volume":"113","author":"JA Roth","year":"2010","unstructured":"Roth JA et al (2010) Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1. J Neurochem 113(2):454\u2013464","journal-title":"J Neurochem"},{"issue":"2","key":"1054_CR29","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1093\/toxsci\/kfq126","volume":"116","author":"M Ni","year":"2010","unstructured":"Ni M et al (2010) Methylmercury induces acute oxidative stress, altering Nrf2 protein level in primary microglial cells. Toxicol Sci 116(2):590\u2013603","journal-title":"Toxicol Sci"},{"issue":"2","key":"1054_CR30","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/jnr.20638","volume":"82","author":"DH Hyun","year":"2005","unstructured":"Hyun DH et al (2005) Effect of overexpression of wild-type or mutant parkin on the cellular response induced by toxic insults. J Neurosci Res 82(2):232\u2013244","journal-title":"J Neurosci Res"},{"issue":"Suppl 1","key":"1054_CR31","first-page":"24","volume":"13","author":"P Jenner","year":"1998","unstructured":"Jenner P (1998) Oxidative mechanisms in nigral cell death in Parkinson\u2019s disease. Mov Disord 13(Suppl 1):24\u201334","journal-title":"Mov Disord"},{"issue":"16","key":"1054_CR32","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/hmg\/ddh180","volume":"13","author":"H Jiang","year":"2004","unstructured":"Jiang H et al (2004) Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis. Hum Mol Genet 13(16):1745\u20131754","journal-title":"Hum Mol Genet"},{"issue":"6809","key":"1054_CR33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","volume":"408","author":"T Finkel","year":"2000","unstructured":"Finkel T, Holbrook NJ (2000) Oxidants, oxidative stress and the biology of ageing. Nature 408(6809):239\u2013247","journal-title":"Nature"},{"issue":"7","key":"1054_CR34","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S0047-6374(01)00422-5","volume":"123","author":"GJ Lithgow","year":"2002","unstructured":"Lithgow GJ, Walker GA (2002) Stress resistance as a determinate of C. elegans lifespan. Mech Ageing Dev 123(7):765\u2013771","journal-title":"Mech Ageing Dev"},{"issue":"15","key":"1054_CR35","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1101\/gad.1107803","volume":"17","author":"JH An","year":"2003","unstructured":"An JH, Blackwell TK (2003) SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response. Genes Dev 17(15):1882\u20131893","journal-title":"Genes Dev"},{"issue":"1","key":"1054_CR36","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1756-6606-5-35","volume":"5","author":"Y Imaizumi","year":"2012","unstructured":"Imaizumi Y et al (2012) Mitochondrial dysfunction associated with increased oxidative stress and alpha-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. Mol Brain 5(1):35","journal-title":"Mol Brain"},{"issue":"2","key":"1054_CR37","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.taap.2010.07.023","volume":"248","author":"KJ Helmcke","year":"2010","unstructured":"Helmcke KJ, Aschner M (2010) Hormetic effect of methylmercury on Caenorhabditis elegans. Toxicol Appl Pharmacol 248(2):156\u2013164","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"1054_CR38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/abio.1999.4257","volume":"274","author":"E Bramanti","year":"1999","unstructured":"Bramanti E et al (1999) Application of mercury cold vapor atomic fluorescence spectrometry to the characterization of mercury-accessible-SH groups in native proteins. Anal Biochem 274(2):163\u2013173","journal-title":"Anal Biochem"},{"key":"1054_CR39","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.brainres.2010.06.065","volume":"1352","author":"G Oyama","year":"2010","unstructured":"Oyama G et al (2010) Impaired in vivo dopamine release in parkin knockout mice. Brain Res 1352:214\u2013222","journal-title":"Brain Res"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-013-1054-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-013-1054-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-013-1054-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T10:45:22Z","timestamp":1715251522000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-013-1054-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,23]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["1054"],"URL":"https:\/\/doi.org\/10.1007\/s11064-013-1054-8","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,23]]}}}