{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:51:34Z","timestamp":1790261494764,"version":"4.1.0"},"reference-count":188,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2013,5,16]],"date-time":"2013-05-16T00:00:00Z","timestamp":1368662400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1007\/s11064-013-1060-x","type":"journal-article","created":{"date-parts":[[2013,5,15]],"date-time":"2013-05-15T04:55:55Z","timestamp":1368593755000},"page":"1523-1542","source":"Crossref","is-referenced-by-count":108,"title":["Acetyl-CoA the Key Factor for Survival or Death of Cholinergic Neurons in Course of Neurodegenerative Diseases"],"prefix":"10.1007","volume":"38","author":[{"given":"Andrzej","family":"Szutowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"Bielarczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Jankowska-Kulawy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeusz","family":"Pawe\u0142czyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Ronowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,16]]},"reference":[{"key":"1060_CR1","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1007\/BF00964982","volume":"10","author":"RF Butterworth","year":"1985","unstructured":"Butterworth RF, Giguere JF, Besnard AM (1985) Activities of thiamine-dependent enzymes in two experimental models of thiamine-deficiency encephalopathy: 1. The pyruvate dehydrogenase complex. Neurochem Res 10:1417\u20131428","journal-title":"Neurochem Res"},{"key":"1060_CR2","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1007\/BF00965673","volume":"7","author":"A Szutowicz","year":"1982","unstructured":"Szutowicz A, St\u0119pie\u0144 M, Bielarczyk H, Kabata J, \u0141ysiak W (1982) ATP citrate lyase in cholinergic nerve endings. Neurochem Res 7:799\u2013810","journal-title":"Neurochem Res"},{"key":"1060_CR3","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1471-4159.1980.tb07073.x","volume":"35","author":"A Szutowicz","year":"1980","unstructured":"Szutowicz A, \u0141ysiak W (1980) Regional and subcellular distribution of ATP-citrate lyase and other enzymes of acetyl-CoA metabolism in rat brain. J Neurochem 35:775\u2013785","journal-title":"J Neurochem"},{"key":"1060_CR4","first-page":"71","volume":"16","author":"R Duelli","year":"2001","unstructured":"Duelli R, Kuschinsky W (2001) Brain glucose transporters: relationship to local energy demand. News Physiol Sci 16:71\u201376","journal-title":"News Physiol Sci"},{"key":"1060_CR5","first-page":"139","volume-title":"Handbook of neurochemistry and molecular neurobiology. Brain energetics. Integration of molecular and cellular processes","author":"EL Roberts Jr","year":"2007","unstructured":"Roberts EL Jr (2007) The support of energy metabolism in the central nervous system with substrates other than glucose. In: Lajtha A, Gibson GE, Dienel GA (eds) Handbook of neurochemistry and molecular neurobiology. Brain energetics. Integration of molecular and cellular processes. Springer, Berlin, pp 139\u2013179"},{"key":"1060_CR6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.55782\/ane-1996-1137","volume":"56","author":"A Szutowicz","year":"1996","unstructured":"Szutowicz A, Tomaszewicz M, Bielarczyk H (1996) Disturbances of acetyl-CoA, energy and acetylcholine metabolism in some encephalopathies. Acta Neurobiol Exp 56:323\u2013339","journal-title":"Acta Neurobiol Exp"},{"key":"1060_CR7","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1097\/00001756-199412000-00004","volume":"5","author":"A Szutowicz","year":"1994","unstructured":"Szutowicz A, Tomaszewicz M, Jankowska A, Kisielevski Y (1994) Acetylcholine synthesis in nerve terminals of diabetic rats. NeuroReport 5:2421\u20132424","journal-title":"NeuroReport"},{"key":"1060_CR8","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/sj.jcbfm.9600568","volume":"28","author":"S Serres","year":"2008","unstructured":"Serres S, Raffard G, Franconi JM, Merle M (2008) Close coupling between astrocytic and neuronal metabolomics to fulfill anaplerotic and energy needs in the rat brain. J Cereb Blood Flow Metab 28:712\u2013724","journal-title":"J Cereb Blood Flow Metab"},{"key":"1060_CR9","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1002\/iub.572","volume":"64","author":"AP Halestrap","year":"2012","unstructured":"Halestrap AP, Wilson MC (2012) The monocarboxylate transporter family\u2014role and regulation. IUBMB Life 64:109\u2013119","journal-title":"IUBMB Life"},{"key":"1060_CR10","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1007\/s11064-010-0224-1","volume":"35","author":"S Wohnsland","year":"2010","unstructured":"Wohnsland S, Burgers HF, Kuschinsky W, Maurer MH (2010) Neurons and neuronal stem cells survive in glucose-free lactate and in high glucose cell culture medium during normoxia and anoxia. Neurochem Res 35:1635\u20131642","journal-title":"Neurochem Res"},{"key":"1060_CR11","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/jcbfm.2011.175","volume":"32","author":"GA Dienel","year":"2011","unstructured":"Dienel GA (2011) Brain lactate metabolism: the discoveries and the controversies. J Cereb Blood Flow Metab 32:1107\u20131138","journal-title":"J Cereb Blood Flow Metab"},{"key":"1060_CR12","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/978-0-387-30373-4_14","volume-title":"Handbook of neurochemistry and molecular biology. Amino acids and peptides in the nervous system","author":"MH Baslow","year":"2007","unstructured":"Baslow MH (2007) N-acetylaspartate and N-acetylaspartylglutamate. In: Oja SS, Schousboe A, Saransaari P (eds) Handbook of neurochemistry and molecular biology. Amino acids and peptides in the nervous system, 3rd edn. Springer, New York, pp 305\u2013346","edition":"3"},{"key":"1060_CR13","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ana.20474","volume":"57","author":"P Bubber","year":"2005","unstructured":"Bubber P, Haroutunian V, Fisch G, Blass JP, Gibson GE (2005) Mitochondrial abnormalities in Alzheimer brain: mechanistic implications. Ann Neurol 57:695\u2013703","journal-title":"Ann Neurol"},{"key":"1060_CR14","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1159\/000017347","volume":"20","author":"A Szutowicz","year":"1998","unstructured":"Szutowicz A, Tomaszewicz M, Bielarczyk H, Jankowska A (1998) Putative significance of shifts in acetyl-CoA compartmentalization in nerve terminals for disturbances of cholinergic transmission in brain. Devel Neurosci 20:485\u2013492","journal-title":"Devel Neurosci"},{"key":"1060_CR15","first-page":"29","volume":"15","author":"A Szutowicz","year":"2000","unstructured":"Szutowicz A, Tomaszewicz M, Jankowska A, Madziar B, Bielarczyk H (2000) Acetyl-CoA metabolism in cholinergic neurons and their susceptibility to neurotoxic inputs. Met Brain Dis 15:29\u201344","journal-title":"Met Brain Dis"},{"key":"1060_CR16","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuint.2013.01.004","volume":"62","author":"DP Bhatt","year":"2013","unstructured":"Bhatt DP, Houdek HM, Watt JA, Rosenberger TA (2013) Acetate supplementation increases brain phosphocreatine and reduces AMP levels with no effects on mitochondrial biogenesis. Neurochem Int 62:296\u2013305","journal-title":"Neurochem Int"},{"key":"1060_CR17","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1471-4159.2012.07955.x","volume":"123","author":"ML Soliman","year":"2012","unstructured":"Soliman ML, Ping KL, Combs CK, Rosenberger TA (2012) Acetate reduces microglia inflammatory signaling in vitro. J Neurochem 123:555\u2013567","journal-title":"J Neurochem"},{"key":"1060_CR18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jmr.2008.11.001","volume":"196","author":"DK Deelchand","year":"2009","unstructured":"Deelchand DK, Nelson C, Shestov AA, Ugurbil K, Henry PG (2009) Simultaneous measurement of neuronal and glial metabolism in rat brain in vivo using co-infusion of [1,6\u201313C]glucose and [1,2,-13C]acetate. J Magn Reson 196:157\u2013163","journal-title":"J Magn Reson"},{"key":"1060_CR19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2202-8-35","volume":"8","author":"JD Laughton","year":"2007","unstructured":"Laughton JD, Bittar P, Charnay Y, Pellerin L, Kovari E, Magistretti PJ, Bouras C (2007) Metabolic compartmentalization in the human cortex and hippocampus: evidence for a cell- and region-specific localization of lactate dehydrogenase 5 and pyruvate dehydrogenase. BMC Neurosci 8:35","journal-title":"BMC Neurosci"},{"key":"1060_CR20","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/glia.20996","volume":"58","author":"ND Halim","year":"2010","unstructured":"Halim ND, McFate T, Mohyeldin A, Okagaki P, Korotchkina LG, Patel MS, Jeoung NH, Harris RA, Schell MJ, Verma A (2010) Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons. Glia 58:1168\u20131176","journal-title":"Glia"},{"key":"1060_CR21","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1471-4159.2009.06333.x","volume":"111","author":"GK Gandhi","year":"2009","unstructured":"Gandhi GK, Cruz NF, Ball KK, Dienel GA (2009) Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons. J Neurochem 111:522\u2013536","journal-title":"J Neurochem"},{"key":"1060_CR22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0197-0186(03)00020-2","volume":"43","author":"L Pellerin","year":"2003","unstructured":"Pellerin L (2003) Lactate as a pivotal element in neuron-glia metabolite cooperation. Neurochem Int 43:331\u2013338","journal-title":"Neurochem Int"},{"key":"1060_CR23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuroscience.2006.11.062","volume":"145","author":"LH Bergersen","year":"2007","unstructured":"Bergersen LH (2007) Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle. Neuroscience 145:11\u201319","journal-title":"Neuroscience"},{"key":"1060_CR24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.neuint.2003.10.010","volume":"45","author":"U Sonnewald","year":"2004","unstructured":"Sonnewald U, Schousboe A, Qu H, Waagepetersen HS (2004) Intracellular metabolic compartmentation assessed by 13C magnetic resonance spectroscopy. Neurochem Int 45:305\u2013310","journal-title":"Neurochem Int"},{"key":"1060_CR25","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1111\/j.1471-4159.1981.tb06326.x","volume":"37","author":"SF Leong","year":"1981","unstructured":"Leong SF, Lai JCK, Lim L, Clark JB (1981) Energy-metabolising enzymes in brain regions of adult and aging rats. J Neurochem 37:1548\u20131556","journal-title":"J Neurochem"},{"key":"1060_CR26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/(SICI)1097-4547(19990701)57:1<131::AID-JNR14>3.0.CO;2-M","volume":"57","author":"A Szutowicz","year":"1999","unstructured":"Szutowicz A, Jankowska A, Blusztajn JK, Tomaszewicz M (1999) Acetylcholine and acetyl-CoA metabolism in differentiating SN56 septal cell line. J Neurosci Res 57:131\u2013136","journal-title":"J Neurosci Res"},{"key":"1060_CR27","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s11011-006-9007-4","volume":"21","author":"A Szutowicz","year":"2006","unstructured":"Szutowicz A, Bielarczyk H, Gul S, Ronowska A, Pawe\u0142czyk T, Jankowska-Kulawy A (2006) Phenotype-dependent susceptibility of cholinergic neuroblastoma cells to neurotoxic inputs. Metab Brain Dis 21:149\u2013161","journal-title":"Metab Brain Dis"},{"key":"1060_CR28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0014-5793(74)80006-2","volume":"39","author":"JE Cremer","year":"1974","unstructured":"Cremer JE, Teal HM (1974) The activity of pyruvate dehedrogenase in rat brain during postnatal development. FEBS Lett 39:17\u201320","journal-title":"FEBS Lett"},{"key":"1060_CR29","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1042\/bj2380729","volume":"238","author":"GDA Malloch","year":"1986","unstructured":"Malloch GDA, Munday LA, Olson MS, Clark JB (1986) Comparative development of the pyruvate dehydrogenase complex and citrate synthase in rat brain mitochondria. Biochem J 238:729\u2013736","journal-title":"Biochem J"},{"key":"1060_CR30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0165-3806(00)00134-6","volume":"125","author":"CR Buerstatte","year":"2000","unstructured":"Buerstatte CR, Behar KL, Novotny EJ Jr, Lai JCK (2000) Brain regional development of the activity and \u03b1-ketoglutarate dehydrogenase complex in the rat. Devel Brain Res 125:139\u2013145","journal-title":"Devel Brain Res"},{"key":"1060_CR31","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/0020-711X(80)90263-3","volume":"11","author":"A Szutowicz","year":"1980","unstructured":"Szutowicz A, Kabata J, \u0141ysiak W (1980) ATP citrate lyase and other enzymes of acetyl-CoA metabolism in developing rat cerebrum and cerebellum. Int J Biochem 11:545\u2013549","journal-title":"Int J Biochem"},{"key":"1060_CR32","first-page":"133","volume":"59","author":"DS Albers","year":"2000","unstructured":"Albers DS, Beal MF (2000) Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. J Neural Transm [Suppl] 59:133\u2013154","journal-title":"J Neural Transm [Suppl]"},{"key":"1060_CR33","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1007\/s11064-010-0295-z","volume":"35","author":"F Domenico Di","year":"2010","unstructured":"Di Domenico F, Perluigi M, Butterfield DA, Cornelius C, Calabrese V (2010) Oxidative damage in rat brain during aging: interplay between energy and metabolic key target proteins. Neurochem Res 35:2184\u20132192","journal-title":"Neurochem Res"},{"key":"1060_CR34","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1471-4159.2010.06803.x","volume":"114","author":"RM Uranga","year":"2010","unstructured":"Uranga RM, Bruce-Keller AJ, Morrison CD, Fernandez-Kim SO, Ebenezer PJ, Zang L, Dasuri K, Keller JN (2010) Intersection between metabolic dysfunction, high fat diet consumption and brain aging. J Neurochem 114:344\u2013361","journal-title":"J Neurochem"},{"key":"1060_CR35","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1111\/j.1471-4159.2006.03966.x","volume":"98","author":"H Bielarczyk","year":"2006","unstructured":"Bielarczyk H, Gul S, Ronowska A, Bizon-Zygma\u0144ska D, Pawe\u0142czyk T, Szutowicz A (2006) RS-\u03b1-lipoic amid protects cholinergic cells against sodium nitroprusside and amyloid-\u03b2 neurotoxicity through restoration of acetyl-CoA level. J Neurochem 98:1242\u20131251","journal-title":"J Neurochem"},{"key":"1060_CR36","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1471-4159.2010.06919.x","volume":"115","author":"A Jankowska-Kulawy","year":"2010","unstructured":"Jankowska-Kulawy A, Bielarczyk H, Pawe\u0142czyk T, Wr\u00f3blewska M, Szutowicz A (2010) Acetyl-CoA and acetylcholine metabolism in nerve terminal compartment of thiamine deficient rat brain. J Neurochem 115:333\u2013342","journal-title":"J Neurochem"},{"key":"1060_CR37","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1111\/j.1471-4159.2007.04786.x","volume":"103","author":"A Ronowska","year":"2007","unstructured":"Ronowska A, Gul-Hinc S, Bielarczyk H, Pawe\u0142czyk T, Szutowicz A (2007) Effects of zinc on SN56 cholinergic neuroblastoma cells. J Neurochem 103:972\u2013983","journal-title":"J Neurochem"},{"key":"1060_CR38","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.neuint.2009.09.012","volume":"56","author":"A Ronowska","year":"2010","unstructured":"Ronowska A, Dy\u015b A, Jankowska-Kulawy A, Klimaszewska-\u0141ata J, Bielarczyk H, Romianowski P, Pawe\u0142czyk T, Szutowicz A (2010) Short-term effects of zinc on acetylcholine metabolism and viability of SN56 cholinergic neuroblastom cells. Neurochem Int 56:143\u2013151","journal-title":"Neurochem Int"},{"key":"1060_CR39","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.neuint.2010.12.016","volume":"58","author":"G Paradies","year":"2011","unstructured":"Paradies G, Pertosillo G, Paradies V, Ruggiero FM (2011) Mitochondrial dysfunction in brain aging: role of oxidative stress and cardiolipin. Neurochem Int 58:447\u2013457","journal-title":"Neurochem Int"},{"key":"1060_CR40","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.febslet.2009.02.043","volume":"583","author":"Q Zhou","year":"2009","unstructured":"Zhou Q, Lam PY, Han D, Cadenas E (2009) Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging. FEBS Lett 583:1132\u20131140","journal-title":"FEBS Lett"},{"key":"1060_CR41","doi-asserted-by":"crossref","first-page":"6957","DOI":"10.1016\/S0021-9258(19)43346-2","volume":"248","author":"RW Guynn","year":"1973","unstructured":"Guynn RW, Gelberg HJ, Veech R (1973) Equilibrium constants of the malate dehydrogenase, citrate synthase, citrate lyase, and acetyl-CoA hydrolysis reactions under physiological conditions. J Biol Chem 248:6957\u20136965","journal-title":"J Biol Chem"},{"key":"1060_CR42","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00018-005-4516-6","volume":"62","author":"CH Choi","year":"2005","unstructured":"Choi CH, Zimon A, Usheva A (2005) Metabolic stress regulates basic transcription through acetyl-coenzyme A. Cell Mol Life Sci 62:625\u2013628","journal-title":"Cell Mol Life Sci"},{"key":"1060_CR43","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1042\/bj1880683","volume":"188","author":"J Ricny","year":"1980","unstructured":"Ricny J, Tucek S (1980) Relation between the content of acetyl-coenzyme A and acetylcholine in brain slices. Biochem J 188:683\u2013688","journal-title":"Biochem J"},{"key":"1060_CR44","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1471-4159.1977.tb09635.x","volume":"29","author":"A Szutowicz","year":"1977","unstructured":"Szutowicz A, \u0141ysiak W, Angielski S (1977) Effect of (\u2212)hydroxycitrate on pyruvate metabolism in rat brain synaptosomes. J Neurochem 29:375\u2013378","journal-title":"J Neurochem"},{"key":"1060_CR45","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1042\/bj2620377","volume":"262","author":"H Bielarczyk","year":"1989","unstructured":"Bielarczyk H, Szutowicz A (1989) Evidence for the regulatory function of synaptoplasmic acetyl-CoA in acetylcholine synthesis in nerve endings. Biochem J 262:377\u2013380","journal-title":"Biochem J"},{"key":"1060_CR46","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1023\/A:1023267224819","volume":"28","author":"J Deutsch","year":"2003","unstructured":"Deutsch J, Rapoport SI, Rosenberger TA (2003) Valproyl-CoA and estrified valproic acid are not found in brains of rats treated with valproic acid, but the brain concentrations of CoA and acetyl-CoA are altered. Neurochem Res 28:861\u2013866","journal-title":"Neurochem Res"},{"key":"1060_CR47","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1111\/j.1471-4159.1978.tb06585.x","volume":"31","author":"T Kato","year":"1978","unstructured":"Kato T (1978) Ischemic effect on CoASH and acetyl-CoA concentration levels in cerebrum, cerebellum and liver of mice. J Neurochem 31:1545\u20131547","journal-title":"J Neurochem"},{"key":"1060_CR48","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1471-4159.1975.tb07647.x","volume":"24","author":"SF Reynolds","year":"1975","unstructured":"Reynolds SF, Blass JP (1975) Normal levels of acetyl coenzyme A and acetylcholine in the brains of thiamine deficient rats. J Neurochem 24:185\u2013186","journal-title":"J Neurochem"},{"key":"1060_CR49","doi-asserted-by":"crossref","first-page":"4919","DOI":"10.1016\/S0021-9258(19)69344-0","volume":"256","author":"J Ricny","year":"1981","unstructured":"Ricny J, Tucek S (1981) Acetyl-coenzyme A and acetylcholine in slices of rat caudate nuclei incubated in the presence of metabolic inhibitors. J Biol Chem 256:4919\u20134923","journal-title":"J Biol Chem"},{"key":"1060_CR50","first-page":"27","volume":"2","author":"J Ricny","year":"1983","unstructured":"Ricny J, Tucek S (1983) Ca2+ ions and the output of acetyl-CoA from brain mitochondria. Gen Physiol Biophys 2:27\u201337","journal-title":"Gen Physiol Biophys"},{"key":"1060_CR51","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1111\/j.1471-4159.1977.tb07707.x","volume":"28","author":"PA Shea","year":"1977","unstructured":"Shea PA, Aprison MH (1977) The distribution of acetyl-CoA in specific areas of the CNS of the rat and measured by modification od a radio-enzymatic assay for acetylcholine and choline. J Neurochem 28:51\u201358","journal-title":"J Neurochem"},{"key":"1060_CR52","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1471-4159.1966.tb05877.x","volume":"16","author":"J Schuberth","year":"1966","unstructured":"Schuberth J, Sollenberg J, Sundwall A, Sorbo B (1966) Acetylcoenzyme A in brain. The effect of centrally active drugs, insulin coma and hypoxia. J Neurochem 16:819\u2013822","journal-title":"J Neurochem"},{"key":"1060_CR53","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0003-2697(87)90495-7","volume":"164","author":"A Szutowicz","year":"1987","unstructured":"Szutowicz A, Bielarczyk H (1987) Elimination of CoA-SH interference from acetyl-CoA assay by maleic anhydride. Anal Biochem 164:292\u2013296","journal-title":"Anal Biochem"},{"key":"1060_CR54","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1111\/j.1471-4159.2004.02556.x","volume":"90","author":"A Szutowicz","year":"2004","unstructured":"Szutowicz A, Madziar B, Pawe\u0142czyk T, Tomaszewicz M, Bielarczyk H (2004) Effect of NGF on acetylcholine, acetyl-CoA metabolism, and viability of differentiated and non-differentiated cholinergic neuroblastom cells. J Neurochem 90:952\u2013961","journal-title":"J Neurochem"},{"key":"1060_CR55","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1002\/jnr.20276","volume":"79","author":"A Szutowicz","year":"2005","unstructured":"Szutowicz A, Bielarczyk H, Gul S, Zieli\u0144ski P, Pawe\u0142czyk T, Tomaszewicz M (2005) Nerve growth factor and acetyl-L-carnitine evoked shifts in acetyl-CoA and cholinergic SN56 cell vulnerability to neurotoxic inputs. J Neurosci Res 79:185\u2013192","journal-title":"J Neurosci Res"},{"key":"1060_CR56","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1046\/j.1471-4159.1998.70031175.x","volume":"70","author":"H Bielarczyk","year":"1998","unstructured":"Bielarczyk H, Tomaszewicz M, Szutowicz A (1998) Effect of aluminium on acetyl-CoA and acetylcholine metabolism in nerve terminals. J Neurochem 70:1175\u20131181","journal-title":"J Neurochem"},{"key":"1060_CR57","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/205766a0","volume":"205","author":"PA Srere","year":"1965","unstructured":"Srere PA (1965) The molecular physiology of citrate. Nature 205:766\u2013770","journal-title":"Nature"},{"key":"1060_CR58","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1111\/j.1471-4159.1981.tb00570.x","volume":"36","author":"S Tucek","year":"1981","unstructured":"Tucek S, Dolezal V, Sullivan AC (1981) Inhibition of the synthesis of acetylcholine in rat brain slices by (\u2212)hydroxycitrate and citrate. J Neurochem 36:1331\u20131337","journal-title":"J Neurochem"},{"key":"1060_CR59","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1111\/j.1471-4159.1981.tb00569.x","volume":"36","author":"V Dolezal","year":"1981","unstructured":"Dolezal V, Tucek S (1981) Utilization of citrate acetylcarnitine, acetate and glucose for the synthesis of acetylcholine in rat brain slices. J Neurochem 36:1323\u20131330","journal-title":"J Neurochem"},{"key":"1060_CR60","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0006-8993(92)90683-Z","volume":"576","author":"J Ricny","year":"1992","unstructured":"Ricny J, Tucek S, Novakova J (1992) Acetylcarnitine, carnitine and glucose diminish the effect of muscarinic antagonist quinuclidinyl benzilate on striatal acetylcholine content. Brain Res 576:215\u2013219","journal-title":"Brain Res"},{"key":"1060_CR61","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/j.1471-4159.2010.06807.x","volume":"114","author":"S Scafidi","year":"2010","unstructured":"Scafidi S, Fiskum G, Lindauer SL, Bamford P, Shi D, Hopkins I, McKenna MC (2010) Metabolism of acetyl-L-carnitine for energy and neurotransmitter synthesis in the immature brain. J Neurochem 114:820\u2013831","journal-title":"J Neurochem"},{"key":"1060_CR62","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1460-9568.2010.07576.x","volume":"33","author":"A Barsukova","year":"2011","unstructured":"Barsukova A, Komarov A, Hajnoczky G, Bernardi P, Bourdette D, Forte M (2011) Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons. Eur J Neurosci 33:831\u2013842","journal-title":"Eur J Neurosci"},{"key":"1060_CR63","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1046\/j.1471-4159.2003.01905.x","volume":"86","author":"NC Madhavarao","year":"2003","unstructured":"Madhavarao NC, Chinopoulos C, Chandrasekaran K, Namboodiri MAA (2003) Characterization of the N-acetylaspartate biosynthetic enzyme from rat brain. J Neurochem 86:824\u2013835","journal-title":"J Neurochem"},{"key":"1060_CR64","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.nlm.2012.01.006","volume":"97","author":"T Watanabe","year":"2012","unstructured":"Watanabe T, Shiino A, Akiguchi I (2012) Hippocampal metabolites and memory performances in patients with amnestic mild cognitive impairment and Alzheimer\u2019s disease. Neurobiol Learn Mem 97:289\u2013293","journal-title":"Neurobiol Learn Mem"},{"key":"1060_CR65","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1126\/science.1164097","volume":"324","author":"KE Wellen","year":"2009","unstructured":"Wellen KE, Hatzivassiliou G, Sachdeva UM, Bui TV, Cross JR, Thompson CB (2009) ATP-citrate lyase links cellular metabolism to histone acetylation. Science 324:1076\u20131080","journal-title":"Science"},{"key":"1060_CR66","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0079-6107(93)90013-A","volume":"60","author":"S Tucek","year":"1993","unstructured":"Tucek S (1993) Short-term control of the synthesis of acetylcholine. Prog Biophys Molec Biol 60:59\u201369","journal-title":"Prog Biophys Molec Biol"},{"key":"1060_CR67","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1046\/j.1471-4159.1998.70062227.x","volume":"70","author":"LE Eiden","year":"1998","unstructured":"Eiden LE (1998) The cholinergic gene locus. J Neurochem 70:2227\u20132240","journal-title":"J Neurochem"},{"key":"1060_CR68","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1523\/JNEUROSCI.08-08-02967.1988","volume":"8","author":"J Hartikka","year":"1988","unstructured":"Hartikka J, Hefti F (1988) Development of septal cholinergic neurons in culture: plating density and glial cells modulate effects of NGF on survival, fiber growth, and expression of transmitter specific enzymes. J Neurosci 8:2967\u20132985","journal-title":"J Neurosci"},{"key":"1060_CR69","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1523\/JNEUROSCI.21-10-03375.2001","volume":"21","author":"DS Auld","year":"2001","unstructured":"Auld DS, Mennicken F, Quirion R (2001) Nerve growth factor rapidly induces prolonged acetylcholine release from cultured basal forebrain neurons: differentiation between neuromodulatory and neurotrophic influences. J Neurosci 21:3375\u20133382","journal-title":"J Neurosci"},{"key":"1060_CR70","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.neuint.2010.12.011","volume":"58","author":"T Yamada","year":"2011","unstructured":"Yamada T, Inazu M, Tajima H, Matsumiya T (2011) Functional expression of choline transporter-like protein 1 (CTL1) in human neuroblastom cells and its link to acetylcholine synthesis. Neurochem Int 58:354\u2013365","journal-title":"Neurochem Int"},{"key":"1060_CR71","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0197-4580(97)00038-9","volume":"18","author":"SMN Efange","year":"1997","unstructured":"Efange SMN, Garland EM, Stanley JK, Khare AB, Mash DC (1997) Vesicular acetylcholine transporter density and Alzheimer\u2019s disease. Neurobiol Aging 18:407\u2013413","journal-title":"Neurobiol Aging"},{"key":"1060_CR72","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s00702-006-0579-2","volume":"113","author":"R Schliebs","year":"2006","unstructured":"Schliebs R, Arendt T (2006) The significance of the cholinergic system in the brain during aging and Alzheimer\u2019s disease. J Neural Transm 113:1625\u20131644","journal-title":"J Neural Transm"},{"key":"1060_CR73","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0197-4580(87)90034-0","volume":"8","author":"MG Vanucchi","year":"1987","unstructured":"Vanucchi MG, Pepeu G (1987) Effect of phosphatidylserine on acetylcholine release and content in cortical slices from aging rats. Neurobiol Aging 8:403\u2013407","journal-title":"Neurobiol Aging"},{"key":"1060_CR74","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.neulet.2009.03.030","volume":"454","author":"F Wang","year":"2009","unstructured":"Wang F, Chen H, Sun X (2009) Age-related spatial cognitive impairment is correlated with a decrease in ChAT in cerebral cortex, hippocampus and forebrain of SAMP8 mice. Neurosci Lett 454:212\u2013217","journal-title":"Neurosci Lett"},{"key":"1060_CR75","author":"AM Fortress","year":"2011","unstructured":"Fortress AM, Buhusi M, Helke KL, Granholm ACE (2011) Cholinergic degeneration and alterations in the TrkA and p75NTR balance as a result of pro-NGF injection into aged rats. J Aging Res. doi: 10.4061\/2011\/460543","journal-title":"J Aging Res"},{"key":"1060_CR76","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/j.1471-4159.1981.tb05319.x","volume":"37","author":"PJ Richardson","year":"1981","unstructured":"Richardson PJ (1981) Quantitation of cholinergic synaptosomes from guinea pig brain. J Neurochem 37:258\u2013260","journal-title":"J Neurochem"},{"key":"1060_CR77","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/jnr.10711","volume":"73","author":"H Bielarczyk","year":"2003","unstructured":"Bielarczyk H, Tomaszewicz M, Madziar B, \u0106wikowska J, Pawe\u0142czyk T, Szutowicz A (2003) Relationships between cholinergic phenotype and acetyl-CoA level in hybrid Marine neuroblastoma cells of sep tal origin. J Neurosci Res 73:717\u2013721","journal-title":"J Neurosci Res"},{"key":"1060_CR78","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1471-4159.1973.tb00079.x","volume":"20","author":"P Lefresne","year":"1973","unstructured":"Lefresne P, Guyenet P, Glowinski J (1973) Acetylcholine synthesis from [2-14C] pyruvate in rat striatal slices. J Neurochem 20:1083\u20131097","journal-title":"J Neurochem"},{"key":"1060_CR79","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0197-0186(02)00097-9","volume":"42","author":"H Bielarczyk","year":"2003","unstructured":"Bielarczyk H, Jankowska A, Madziar B, Matecki A, Michno A, Szutowicz A (2003) Differential toxicity of nitric oxide, aluminum and amyloid-beta peptide in SN56 cholinergic cells from mouse septum. Neurochem Int 42:323\u2013331","journal-title":"Neurochem Int"},{"key":"1060_CR80","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.molcel.2011.05.004","volume":"42","author":"L Cai","year":"2010","unstructured":"Cai L, Sutter BM, Li B, Tu BP (2010) Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes. Mol Cell 42:426\u2013437","journal-title":"Mol Cell"},{"key":"1060_CR81","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/brain\/aws013","volume":"135","author":"DJ Irwin","year":"2012","unstructured":"Irwin DJ, Cohen TJ, Grossman M, Arnold SE, Xie SX, Lee VMY, Trojanowski JQ (2012) Acetylated tau, a novel pathological signature in Alzheimer\u2019s disease and other tauopathies. Brain 135:807\u2013818","journal-title":"Brain"},{"key":"1060_CR82","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1471-4159.1982.tb03967.x","volume":"39","author":"A Szutowicz","year":"1982","unstructured":"Szutowicz A, Srere PA, Allen CN, Crawford IL (1982) Effects of septal lesions on enzymes of acetyl-CoA metabolism in the cholinergic system of the rat hippocampus. J Neurochem 39:458\u2013463","journal-title":"J Neurochem"},{"key":"1060_CR83","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1111\/j.1471-4159.1983.tb08140.x","volume":"40","author":"A Szutowicz","year":"1983","unstructured":"Szutowicz A, Morrison MR, Srere PA (1983) The enzymes of acetyl-CoA metabolism in differentiating cholinergic (S-20) and noncholinegric (NIE-1150 neuroblastoma cells. J Neurochem 40:1664\u20131770","journal-title":"J Neurochem"},{"key":"1060_CR84","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/330424a0","volume":"330","author":"MJ Selwyn","year":"1987","unstructured":"Selwyn MJ (1987) Holes in mitochondrial inner membranes. Nature 330:424\u2013425","journal-title":"Nature"},{"key":"1060_CR85","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/jnr.1220","volume":"66","author":"S Ando","year":"2001","unstructured":"Ando S, Tadenuma T, Tanaka Y, Fukui F, Kobayashi S, Ohashi Y, Kawabata T (2001) Enhancement of learning capacity and cholinergic synaptic function by carnitine in aging rats. J Neurosci Res 66:266\u2013271","journal-title":"J Neurosci Res"},{"key":"1060_CR86","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0006-8993(90)90255-A","volume":"526","author":"T Aureli","year":"1990","unstructured":"Aureli T, Miccheli A, Ricciolini R, DiCocco ME, Ramacci MT, Agelucci L, Ghirardi O, Conti F (1990) Aging brain: effect of acetyl-L-carnitine treatment on rat brain energy and phospholipid metabolism. A study by 31P and 1H NMR spectroscopy. Brain Res 526:108\u2013112","journal-title":"Brain Res"},{"key":"1060_CR87","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.neuint.2012.06.008","volume":"61","author":"OB Smeland","year":"2012","unstructured":"Smeland OB, Meisingset TW, Sonnewald U (2012) Dietary supplementation with acetyl-L-carnitine in seizure treatment of phenylenetetrazole kindled mice. Neurochem Int 61:444\u2013454","journal-title":"Neurochem Int"},{"key":"1060_CR88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-4580(95)80001-8","volume":"16","author":"JW Pettegrew","year":"1995","unstructured":"Pettegrew JW, Klunk WE, Panchalingam K, Kanfer JM, McClure RJ (1995) Clinical and neurochemical effects of acetyl-L-carnitine in Alzheimer\u2019s disease. Neurobiol Aging 16:1\u20134","journal-title":"Neurobiol Aging"},{"key":"1060_CR89","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.neuint.2004.12.004","volume":"46","author":"C Crochemore","year":"2005","unstructured":"Crochemore C, Pena-Altamira E, Virgili M, Monti B, Contestabile A (2005) Disease-related regressive alterations of forebrain cholinergic system in SOD1 mutant transgenic mice. Neurochem Int 46:357\u2013368","journal-title":"Neurochem Int"},{"key":"1060_CR90","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/00004647-199904000-00001","volume":"19","author":"G Fiskum","year":"1999","unstructured":"Fiskum G, Murphy AN, Beal FM (1999) Mitochondria in neurodgeneration: acute ischemia an chronic neurodegenerative deiseases. J Cereb Bood Flow Metab 19:351\u2013369","journal-title":"J Cereb Bood Flow Metab"},{"key":"1060_CR91","doi-asserted-by":"crossref","first-page":"S335","DOI":"10.3233\/JAD-2010-100348","volume":"20","author":"LJ Martin","year":"2010","unstructured":"Martin LJ (2010) Mitochondrial pathobiology in Parkinson\u2019s disease and amyotrophic lateral sclerosis. J Alzheimer\u2019s Dis 20:S335\u2013S356","journal-title":"J Alzheimer\u2019s Dis"},{"key":"1060_CR92","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0197-4580(00)00090-7","volume":"21","author":"BA Pappas","year":"2000","unstructured":"Pappas BA, Bayley PJ, Bui BK, Hansen LA, Thal LJ (2000) Choline acetyltransferase activity and cognitive domain scores of Alzheimer\u2019s patients. Neurobiol Aging 21:11\u201317","journal-title":"Neurobiol Aging"},{"issue":"Suppl 2","key":"1060_CR93","doi-asserted-by":"crossref","first-page":"S453","DOI":"10.3233\/JAD-2010-100321","volume":"20","author":"GC Higgins","year":"2010","unstructured":"Higgins GC, Beart PM, Shin YS, Chen MJ, Cheung NS, Nagley P (2010) Oxidative stress: emerging mitochondrial and cellular themes and variations in neuronal injury. J Alzheimer\u2019s Dis 20(Suppl 2):S453\u2013S473","journal-title":"J Alzheimer\u2019s Dis"},{"key":"1060_CR94","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nature05292","volume":"443","author":"MT Lin","year":"2006","unstructured":"Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787\u2013795","journal-title":"Nature"},{"issue":"Suppl 2","key":"1060_CR95","doi-asserted-by":"crossref","first-page":"S255","DOI":"10.3233\/JAD-2010-100345","volume":"20","author":"VA Morais","year":"2010","unstructured":"Morais VA, De Strooper B (2010) Mitochondrial dysfunction and neurodegenerative disorders: cause or consequence. J Alzheimer\u2019s Dis 20(Suppl 2):S255\u2013S263","journal-title":"J Alzheimer\u2019s Dis"},{"key":"1060_CR96","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3233\/JAD-2011-111313","volume":"28","author":"J Sun","year":"2012","unstructured":"Sun J, Feng X, Liang D, Duan Y, Lei H (2012) Down-regulation of energy metabolism in Alzheimer\u2019s disease is a protective response of neurons to the microenvironment. J Alzheimer\u2019s Dis 28:389\u2013402","journal-title":"J Alzheimer\u2019s Dis"},{"key":"1060_CR97","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-0-387-30377-2_12","volume-title":"Handbook of neurochemistry and molecular biology 3rd edition, degenerative diseases of the nervous system","author":"S Hoyer","year":"2007","unstructured":"Hoyer S, Frolich I (2007) Dementia: the significance of cerebral metabolic disturbances in Alzheimer\u2019s disease. Relation to Parkinson\u2019s disease. In: Lajtha A, Moussa BH, Riederer P, Mandel SA, Battistin L (eds) Handbook of neurochemistry and molecular biology 3rd edition, degenerative diseases of the nervous system. Springer, New York, pp 189\u2013232"},{"key":"1060_CR98","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/00005072-199409000-00003","volume":"53","author":"DJ Selkoe","year":"1994","unstructured":"Selkoe DJ (1994) Alzheimer\u2019s disease: a central role of amyloid. J Neuropath Exp Neurol 53:438\u2013449","journal-title":"J Neuropath Exp Neurol"},{"key":"1060_CR99","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1111\/j.1471-4159.2006.04426.x","volume":"101","author":"DM Walsh","year":"2007","unstructured":"Walsh DM, Selkoe DJ (2007) A\u03b2 oligomers\u2014a decade of discovery. J Neurochem 101:1172\u20131184","journal-title":"J Neurochem"},{"key":"1060_CR100","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.nbd.2005.07.004","volume":"21","author":"PT Xu","year":"2006","unstructured":"Xu PT, Li YJ, Qin XJ, Scherzer CR, Xu H, Schmechel DE, Hulette CM, Ervin J, Gullans SR, Haines J, Peicak-Vance MA, Gilbert JR (2006) Differences in apolipoprotein E3\/3 and E4\/E4 allele-specific gene expression in hippocampus in Alzheimer\u2019s disease. Neurobiol Dis 21:256\u2013275","journal-title":"Neurobiol Dis"},{"key":"1060_CR101","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng1934","volume":"39","author":"L Bertram","year":"2007","unstructured":"Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE (2007) Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nature Gen 39:17\u201323","journal-title":"Nature Gen"},{"key":"1060_CR102","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nrn3229","volume":"13","author":"H Manji","year":"2012","unstructured":"Manji H, Kato T, Di Prospero NA, Ness S, Beal MF, Krams M, Chen G (2012) Impaired mitochondrial function in psychiatric disorders. Nature Rev Neurosci 13:293\u2013307","journal-title":"Nature Rev Neurosci"},{"key":"1060_CR103","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1074\/jbc.M110.151084","volume":"286","author":"HK Chen","year":"2011","unstructured":"Chen HK, Ji YS, Dodson SE, Miranda RD, Rosenblum CI, Reynolds IJ, Freedman SB, Weisgraber KH, Huang Z, Mahlez RW (2011) Apolipoprotein E4 domain interaction, mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease. J Biol Chem 286:5215\u20135221","journal-title":"J Biol Chem"},{"key":"1060_CR104","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/1531-8249(200009)48:3<297::AID-ANA3>3.0.CO;2-Z","volume":"48","author":"GE Gibson","year":"2000","unstructured":"Gibson GE, Haroutunian V, Zang H, Park LCH, Shi Q, Lesser M, Mohs RC, Sheu RKF, Blass JP (2000) Mitochondrial damage in Alzheimer\u2019s disease varies with apolipoprotein E genotype. Ann Neurol 48:297\u2013303","journal-title":"Ann Neurol"},{"key":"1060_CR105","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-510X(98)00240-8","volume":"161","author":"D Terwel","year":"1998","unstructured":"Terwel D, Bothmer J, Wolf E, Meng F, Jolles J (1998) Affected enzyme activities in Alzheimer\u2019s disease are sensitive to antemortem hypoxia. J Neurol Sci 161:47\u201356","journal-title":"J Neurol Sci"},{"key":"1060_CR106","unstructured":"Benson DF (1983) Alterations in glucose metabolism in Alzheimer\u2019s disease. Banbury report 15. Cold Spring Harbor Laboratory, pp 309\u2013315"},{"key":"1060_CR107","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1471-4159.1989.tb07399.x","volume":"53","author":"RN Kalaria","year":"1989","unstructured":"Kalaria RN, Harik SI (1989) Reduced glucose transporter at blood-brain barrier and in cerebral cortex in Alzheimer\u2019s disease. J Neurochem 53:1083\u20131088","journal-title":"J Neurochem"},{"key":"1060_CR108","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1046\/j.1471-4159.1995.64020749.x","volume":"64","author":"LM Bierer","year":"1995","unstructured":"Bierer LM, Haroutunian V, Gabriel S, Knott PJ, Carlin LS, Purohit DP, Perl DP, Schmeidler J, Kanof P, Davis KL (1995) Neurochemical correlates of dementia severity in Alzheimer\u2019s disease: relative importance of cholinergic deficits. J Neurochem 64:749\u2013760","journal-title":"J Neurochem"},{"key":"1060_CR109","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1023\/A:1025063811290","volume":"23","author":"DM Armstrong","year":"2003","unstructured":"Armstrong DM, Sheffield R, Mishizen-Eberz AJ, Carter TL, Rissman RA, Mizukami K, Ikonomovic MD (2003) Plasticity of glutamate and GABAA receptors in the hippocampus of patients with Alzheimer\u2019s disease. Cell Mol Neurobiol 23:491\u2013505","journal-title":"Cell Mol Neurobiol"},{"key":"1060_CR110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0197-4580(02)00057-X","volume":"24","author":"SA Lyness","year":"2003","unstructured":"Lyness SA, Zarow C, Chui HC (2003) Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis. Neurobiol Aging 24:1\u201323","journal-title":"Neurobiol Aging"},{"key":"1060_CR111","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/jnnp.66.2.137","volume":"66","author":"PT Francis","year":"1999","unstructured":"Francis PT, Palmer AM, Snape M, Wilcock GK (1999) The cholinergic hypothesis of Alzheimer\u2019s disease: a review of progress. J Neurol Neurosurg Psychiatry 66:137\u2013147","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1060_CR112","first-page":"427","volume":"29","author":"S Kar","year":"2004","unstructured":"Kar S, Slowikowski S, Westway D, Mount HTJ (2004) Interactions between \u03b2-amyloid and central cholinergic neurons: implications for Alzheimer\u2019s disease. J Psychiatry Neurosci 29:427\u2013441","journal-title":"J Psychiatry Neurosci"},{"key":"1060_CR113","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1111\/j.1471-4159.2006.03988.x","volume":"97","author":"S Moncada","year":"2006","unstructured":"Moncada S, Bolanos JP (2006) Nitric oxide, cell bioenergetics and neurodegeneration. J Neurochem 97:1676\u20131689","journal-title":"J Neurochem"},{"key":"1060_CR114","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3233\/JAD-2010-1221","volume":"19","author":"MP Murphy","year":"2010","unstructured":"Murphy MP, LeVine H III (2010) Alzheimer\u2019s disease and amyloid-\u03b2 peptide. J Alzheimer\u2019s Dis 19:311\u2013323","journal-title":"J Alzheimer\u2019s Dis"},{"key":"1060_CR115","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1007\/s11064-010-0371-4","volume":"36","author":"MJ Berridge","year":"2011","unstructured":"Berridge MJ (2011) Calcium signaling and Alzheimer\u2019s disease. Neurochem Res 36:1149\u20131156","journal-title":"Neurochem Res"},{"key":"1060_CR116","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nrn2734","volume":"10","author":"SL Sensi","year":"2009","unstructured":"Sensi SL, Paoletti P, Bush AI, Sekler I (2009) Zinc in the physiology and pathology of the CNS. Nat Rev Neurosci 10:780\u2013792","journal-title":"Nat Rev Neurosci"},{"key":"1060_CR117","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1177\/1073858410366481","volume":"16","author":"JR Steinert","year":"2010","unstructured":"Steinert JR, Chernova T, Forsythe ID (2010) Nitric oxide signaling in brain function, dysfunction, and dementia. Neuroscientist 16:435\u2013452","journal-title":"Neuroscientist"},{"key":"1060_CR118","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1002\/jnr.10040","volume":"66","author":"A Szutowicz","year":"2001","unstructured":"Szutowicz A (2001) Aluminum, NO, and nerve growth factor neurotoxicity in cholinergic neurons. J Neurosci Res 66:1009\u20131018","journal-title":"J Neurosci Res"},{"key":"1060_CR119","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0165-6147(03)00100-7","volume":"24","author":"A Caricasole","year":"2003","unstructured":"Caricasole A, Copani A, Caruso A, Caraci F, Iacovelli L, Sortino MA, Terstappen GC, Nicoletti F (2003) The Wnt pathway, cell-cycle activation and \u03b2-amyloid: novel therapeutic strategies in Alzheimer\u2019s disease? Trends Pharmacol Sci 24:233\u2013238","journal-title":"Trends Pharmacol Sci"},{"key":"1060_CR120","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.nbd.2010.10.002","volume":"41","author":"SE Perez","year":"2011","unstructured":"Perez SE, He B, Muhmmad N, Oh KJ, Fahnestock M, Ikonomovic MD, Mufson EJ (2011) Cholinotropic basal forebrain system alterationsin 3xTg-AD transgenic mice. Neurobiol Dis 41:338\u2013352","journal-title":"Neurobiol Dis"},{"key":"1060_CR121","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0006-8993(99)02054-5","volume":"853","author":"JD Oh","year":"2000","unstructured":"Oh JD, Chartisathian K, Chase TN, Butcher LL (2000) Overexpression of neurotrophin receptor p75 contributes to the excitotoxin-induced cholinergic neuronal death in rat basal forebrain. Brain Res 853:174\u2013185","journal-title":"Brain Res"},{"key":"1060_CR122","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s12035-010-8158-9","volume":"44","author":"A Takeda","year":"2011","unstructured":"Takeda A (2011) Zinc signaling in the hippocampus and its relation to pathogenesis of depression. Mol Neurobiol 44:166\u2013174","journal-title":"Mol Neurobiol"},{"key":"1060_CR123","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/1073858403255840","volume":"10","author":"CJ Frederickson","year":"2004","unstructured":"Frederickson CJ, Maret W, Cuajungco MP (2004) Zinc and excitotoxic brain injury. Neuroscientist 10:18\u201325","journal-title":"Neuroscientist"},{"key":"1060_CR124","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.pneurobio.2005.04.005","volume":"75","author":"E Mocchegiani","year":"2005","unstructured":"Mocchegiani E, Bertoni-Freddari C, Marcellini F, Malavolta M (2005) Brain, aging and neurodegeneration: role of zinc ion availability. Progr Neurobiol 75:367\u2013390","journal-title":"Progr Neurobiol"},{"key":"1060_CR125","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.neuint.2004.03.007","volume":"45","author":"MR Hynd","year":"2004","unstructured":"Hynd MR, Scott HL, Dodd PR (2004) Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer\u2019s disease. Neurochem Int 45:583\u2013595","journal-title":"Neurochem Int"},{"key":"1060_CR126","doi-asserted-by":"crossref","first-page":"S487","DOI":"10.3233\/JAD-2010-100306","volume":"20","author":"C Supnet","year":"2010","unstructured":"Supnet C, Bezprozvanny I (2010) Neuronal calcium signaling, mitochondrial dysfunction, and Alzheimer\u2019s disease. J Alzheimer\u2019s Dis 20:S487\u2013S498","journal-title":"J Alzheimer\u2019s Dis"},{"key":"1060_CR127","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.pneurobio.2009.07.009","volume":"89","author":"JT Yu","year":"2009","unstructured":"Yu JT, Chang RCC, Tan L (2009) Calcium dysregulation in Alzheimer\u2019s disease: from mechanisms to therapeutic opportunities. Progr Neurobiol 89:240\u2013255","journal-title":"Progr Neurobiol"},{"key":"1060_CR128","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.neuint.2010.11.019","volume":"58","author":"SS Jhala","year":"2011","unstructured":"Jhala SS, Hazell AS (2011) Modeling neurodegenerative disease pathophysiology in thiamine deficiency: consequences of impaired oxidative metabolism. Neurochem Int 58:248\u2013260","journal-title":"Neurochem Int"},{"key":"1060_CR129","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/BF00973148","volume":"13","author":"CKJ Lai","year":"1988","unstructured":"Lai CKJ, DiLorenzo JC, Sheu KFR (1988) Pyruvate dehydrogenase is inhibited in calcium-loaded cerebrocortical mitochondria. Neurochem Res 13:1043\u20131048","journal-title":"Neurochem Res"},{"key":"1060_CR130","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0361-9230(03)00182-5","volume":"62","author":"P Zatta","year":"2003","unstructured":"Zatta P, Lucchini R, Rensburg SJ, Taylor A (2003) The role of metals in neurodegenerative process: aluminum, manganese and zinc. Brain Res Bull 62:15\u201328","journal-title":"Brain Res Bull"},{"key":"1060_CR131","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuint.2011.04.018","volume":"59","author":"D Bizon-Zygma\u0144ska","year":"2011","unstructured":"Bizon-Zygma\u0144ska D, Jankowska-Kulawy A, Bielarczyk H, Pawe\u0142czyk T, Ronowska A, Marsza\u0142\u0142 M, Szutowicz A (2011) Acetyl-CoA metabolism in amprolium-evoked thiamine pyrophosphate deficits in cholinergic SN56 neuroblastoma cells. Neurochem Int 59:208\u2013216","journal-title":"Neurochem Int"},{"key":"1060_CR132","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0896-6273(04)00015-7","volume":"41","author":"E Bossy-Wetzel","year":"2004","unstructured":"Bossy-Wetzel E, Talantova MV, Lee WD, Scholzke MN, Harrup A, Mathews E, Gotz T, Han J, Ellisman MH, Perkins GA, Lipton SA (2004) Crosstalk between nitric oxide and zinc pathways to neuronal cell death involving mitochondrial dysfunction and p38-activated K+ channels. Neuron 41:351\u2013365","journal-title":"Neuron"},{"key":"1060_CR133","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/s12264-011-1530-6","volume":"27","author":"GH Doherty","year":"2011","unstructured":"Doherty GH (2011) Nitric oxide in neurodegeneration: potential benefits of non-steroidal anti-inflammatories. Neurosci Bull 27:366\u2013382","journal-title":"Neurosci Bull"},{"key":"1060_CR134","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2174\/156720207780637243","volume":"4","author":"DA Personett","year":"2007","unstructured":"Personett DA, Williams K, Baskerville KA, McKinney M (2007) Establishment of cholinergic neuron-like cell lines with differential vulnerability to nitrosative stress. Curr Neurovasc Res 4:75\u201388","journal-title":"Curr Neurovasc Res"},{"key":"1060_CR135","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1097\/00001756-200004070-00007","volume":"11","author":"U Fass","year":"2000","unstructured":"Fass U, Panickar K, Personett D, Bryan D, Williams K, Gonzalez J, Sugaya K, McKinney M (2000) Differential vulnerability of primary cultured cholinergic neurons to nitric oxide excess. NeuroReport 11:931\u2013936","journal-title":"NeuroReport"},{"key":"1060_CR136","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.brainres.2003.12.021","volume":"1002","author":"M McKinney","year":"2004","unstructured":"McKinney M, Williams K, Personett D, Kent C, Bryan D, Gonzalez J, Baskeville K (2004) Pontine cholinergic neurons depend on three neuroprotection systems to resist nitrosative stress. Brain Res 1002:100\u2013109","journal-title":"Brain Res"},{"key":"1060_CR137","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1046\/j.1471-4159.2000.0742412.x","volume":"74","author":"D Personett","year":"2000","unstructured":"Personett D, Fass U, Panickar K, McKinney M (2000) Retinoic acid-mediated enhancement of the cholinergic\/neuronal nitric oxide synthase phenotype of the medial septal SN56 clone establishment of nitric oxide-sensitive proapoptotic state. J Neurochem 74:2412\u20132424","journal-title":"J Neurochem"},{"key":"1060_CR138","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nn.3028","volume":"15","author":"I Benilova","year":"2012","unstructured":"Benilova I, Karran E, De Strooper B (2012) The toxic A\u03b2 oligomer and Alzheimer\u2019s disease: an emperor in need of clothes. Nat Neurosci 15:1\u20139","journal-title":"Nat Neurosci"},{"key":"1060_CR139","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neurobiolaging.2010.03.011","volume":"33","author":"AJ Furst","year":"2012","unstructured":"Furst AJ, Rabinovici GD, Rostomian AH, Steed T, Alkalay A, Racine C, Miller BL, Jagust WJ (2012) Cognition, glucose metabolism and amyloid burden in Alzheimer\u2019s disease. Neurobiol Aging 33:215\u2013225","journal-title":"Neurobiol Aging"},{"key":"1060_CR140","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1079\/NRR200367","volume":"16","author":"RF Butterworth","year":"2003","unstructured":"Butterworth RF (2003) Thiamin deficiency and brain disorders. Nutr Res Rev 16:277\u2013283","journal-title":"Nutr Res Rev"},{"key":"1060_CR141","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s00706-010-0417-y","volume":"142","author":"C Exley","year":"2011","unstructured":"Exley C, House ER (2011) Aluminium in the human brain. Monatsh Chem 142:357\u2013363","journal-title":"Monatsh Chem"},{"key":"1060_CR142","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/nrneurol.2011.42","volume":"7","author":"NM Zahr","year":"2011","unstructured":"Zahr NM, Kimberley L, Harper K, Harper CG (2011) Clinical and pathological features of alcohol-related brain damage. Nature Rev Neurol 7:284\u2013294","journal-title":"Nature Rev Neurol"},{"key":"1060_CR143","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pneurobio.2012.03.005","volume":"97","author":"I Ferrer","year":"2012","unstructured":"Ferrer I (2012) Defining Alzheimer as a common age-related neurodegenerative process not inevitably leading to dementia. Progr Neurobiol 97:38\u201351","journal-title":"Progr Neurobiol"},{"key":"1060_CR144","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.neurobiolaging.2011.09.006","volume":"32","author":"WE Klunk","year":"2011","unstructured":"Klunk WE (2011) Amyloid imaging as a biomarker for cerebral \u03b2-amyloidosis and risk prediction for Alzheimer dementia. Neurobiol Aging 32:S20\u2013S36","journal-title":"Neurobiol Aging"},{"key":"1060_CR145","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.neurobiolaging.2010.05.022","volume":"32","author":"NK Robakis","year":"2011","unstructured":"Robakis NK (2011) Mechanisms of AD neurodegeneration may be independent of A\u03b2 and its derivatives. Neurobiol Aging 32:372\u2013379","journal-title":"Neurobiol Aging"},{"key":"1060_CR146","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0006-8993(96)01363-7","volume":"748","author":"K Ishii","year":"1997","unstructured":"Ishii K, Tamaoka A, Mizusawa H, Shoji SI, Ohtake T, Fraser PE, Takahashi H, Tsui S, Gearing M, Mizutami T, Yamada S et al (1997) A\u03b21-40 but not A\u03b21-42 levels in cortex correlate with apolipoprotein E \u03b54 allele dosage in sporadic Alzheimer\u2019s disease. Brain Res 748:250\u2013252","journal-title":"Brain Res"},{"key":"1060_CR147","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1001\/jama.283.12.1571","volume":"283","author":"J Naslund","year":"2000","unstructured":"Naslund J, Haroutunian V, Mohs R, Davis KI, Greengard P, Buxbaum JD (2000) Correlation between elevated levels of amyloid \u03b2-peptide in the brain and cognitive decline. JAMA 283:1571\u20131577","journal-title":"JAMA"},{"key":"1060_CR148","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1074\/jbc.272.4.2038","volume":"272","author":"M Hoshi","year":"1997","unstructured":"Hoshi M, Takashima A, Yasutake K, Yoshida N, Ishiguro K, Hoshino T, Imahori K (1997) Nontoxic amyloid \u03b2 peptide 1\u201342 suppresses acetylcholine synthesis. J Biol Chem 272:2038\u20132041","journal-title":"J Biol Chem"},{"key":"1060_CR149","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1006\/nbdi.1999.0241","volume":"6","author":"C Perreira","year":"1999","unstructured":"Perreira C, Santos MS, Oliveira C (1999) Involvement of oxidative stress on the impairment of energy metabolism induced by A\u03b2 peptides on PC12 cells: protection by antioxidants. Neurobiol Dis 6:209\u2013219","journal-title":"Neurobiol Dis"},{"key":"1060_CR150","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1046\/j.1471-4159.1997.69010273.x","volume":"69","author":"JN Keller","year":"1997","unstructured":"Keller JN, Pang Z, Geddes JW, Germeyer A, Waeg G, Mattson MPJ (1997) Impairment of glucose and glutamate transport and induction mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid-beta peptide: role of the lipid peroxidation product 4-hydroxynonenal. J Neurochem 69:273\u2013289","journal-title":"J Neurochem"},{"key":"1060_CR151","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S0169-328X(98)00096-5","volume":"57","author":"OF Olesen","year":"1998","unstructured":"Olesen OF, Dago L, Mikkelsen JD (1998) Amyloid \u03b2 neurotoxicity in the cholinergic but not in the serotoninergic phenotype of RN46A cells. Mol Brain Res 57:266\u2013274","journal-title":"Mol Brain Res"},{"key":"1060_CR152","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2007.01.071","volume":"1143","author":"R Resende","year":"2007","unstructured":"Resende R, Pereira C, Agostinho P, Vieira AP, Malva JO, Oliveira CR (2007) Susceptibility of hippocampal neurons to A\u03b2 peptide toxicity is associated with perturbation in Ca2+ homeostasis. Brain Res 1143:11\u201321","journal-title":"Brain Res"},{"key":"1060_CR153","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1006\/nbdi.2001.0398","volume":"8","author":"TO Harkany","year":"2001","unstructured":"Harkany TO, Mahony S, Keikser J, Kelly JP, Konya C, Borostyankoi ZA, Gorcs TJ, Zarandi M, Penke B, Leonard BE, Luiten PGM (2001) \u03b2-Amyloid (1\u201342)-induced cholinergic lesions in rat nucleus basalis bidirectionally modulate serotonergic innervation of the basal forebrain and cerebral cortex. Neurobiol Dis 8:578\u2013667","journal-title":"Neurobiol Dis"},{"key":"1060_CR154","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuroscience.2011.07.058","volume":"194","author":"P Sarkar","year":"2011","unstructured":"Sarkar P, Narayanan J, Harder DR (2011) Differential effect of amyloid beta on the cytochrome P450 epoxygenase activity in rat brain. Neuroscience 194:241\u2013249","journal-title":"Neuroscience"},{"key":"1060_CR155","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1046\/j.1471-4159.2003.02196.x","volume":"88","author":"T Liu","year":"2004","unstructured":"Liu T, Perry G, Chan HW, Verdile G, Martins RN, Smith MA, Atwood CS (2004) Amyloid-\u03b2-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression. J Neurochem 88:554\u2013563","journal-title":"J Neurochem"},{"key":"1060_CR156","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.neurobiolaging.2007.12.013","volume":"30","author":"SS Karuppagounder","year":"2009","unstructured":"Karuppagounder SS, Xu H, Shi Q, Chen LH, Pedrini S, Pechman D, Baker H, Beal MF, Gandy S, Gibson GE (2009) Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer\u2019s mouse model. Neurobiol Aging 30:1578\u20131600","journal-title":"Neurobiol Aging"},{"key":"1060_CR157","doi-asserted-by":"crossref","unstructured":"Zilberter M, Ivanov A, Ziyatdinova S, Mukhatarov M, Malkov A, ALpar A, Tortoriello G, Botting CH, Fulop L, Osypov AA, Pitkanen A, Tanila H, Harkany T, Zilberter Y (2013) Dietary energy substrates reverse early neuronal hyperactivity in a mouse model of Alzheimer\u2019s disease. J Neurochem. doi: 10.1111\/jnc.12127","DOI":"10.1111\/jnc.12127"},{"key":"1060_CR158","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.bcp.2011.06.040","volume":"82","author":"F Zeng","year":"2011","unstructured":"Zeng F, Lu JJ, Zhou XF, Wang YJ (2011) Roles of p75NTR in the pathogenesis of Alzheimer\u2019s disease: a novel therapeutic target. Biochem Pharmacol 82:1500\u20131509","journal-title":"Biochem Pharmacol"},{"key":"1060_CR159","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neuro.2009.06.010","volume":"30","author":"JR Walton","year":"2009","unstructured":"Walton JR (2009) Brain lesions comprised of aluminum-reach cells that lack microtubules may be associated with cognitive deficit of Alzheimer\u2019s disease. NeuroToxicology 30:1059\u20131069","journal-title":"NeuroToxicology"},{"key":"1060_CR160","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1212\/WNL.0b013e31822dc7e1","volume":"77","author":"K Kantarci","year":"2011","unstructured":"Kantarci K, Lowe V, Przybelski SA, Senjem MI, Weingand SD, Ivnik RJ, Roberts R, Geda YE, Boeve BF, Knopman DS, Petersen RC, Jack CR Jr (2011) Magentic resonance spectroscopy, \u03b2-amyloid load, and cognition in a population-based sample of cognitively normal older adults. Neurology 77:951\u2013958","journal-title":"Neurology"},{"key":"1060_CR161","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/s11064-011-0674-0","volume":"37","author":"JR Crawford","year":"2012","unstructured":"Crawford JR, Bjorklund NL, Tagliatella G, Gomer RH (2012) Brain serum amyloid P levels are reduced in individuals that lack dementia while having Alzheimer\u2019s disease neuropathology. Neurochem Res 37:795\u2013801","journal-title":"Neurochem Res"},{"key":"1060_CR162","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00401-010-0734-6","volume":"120","author":"J Blanchard","year":"2010","unstructured":"Blanchard J, Wanka L, Tung YC, Cardenas-Aguayo MC, LaFerla FM, Iqbal K, Grundke-Iqbal I (2010) Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting A\u03b2 and tau pathologies in 3xTg-AD mice. Acta Neuropathol 120:605\u2013621","journal-title":"Acta Neuropathol"},{"key":"1060_CR163","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1460-9568.2010.07379.x","volume":"32","author":"LK Hamilton","year":"2010","unstructured":"Hamilton LK, Aumont A, Julien C, Vadnais A, Calon F, Fernandes KJL (2010) Widespread deficits in adult neurogenesis precede plaque and tangle formation in the 3xTg mouse model of Alzheimer\u2019s disease. Eur J Neurosci 32:905\u2013920","journal-title":"Eur J Neurosci"},{"key":"1060_CR164","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/6374","volume":"2","author":"PE Chapman","year":"1999","unstructured":"Chapman PE, White GL, Jones MW, Cooper-Blacketer D, Marshall VJ, Irizarry M, Younkin L, Good MA, Bliss TVP, Hyman BT, Younkin SG, Hsiao KK (1999) Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci 2:271\u2013276","journal-title":"Nat Neurosci"},{"key":"1060_CR165","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3233\/JAD-2010-1270","volume":"19","author":"K Plaschke","year":"2010","unstructured":"Plaschke K, Kopitz J, Siegelin M, Schliebs R (2010) Insulin-resistant brain state after intracerebroventricular dtreptozotocin injection exacerbates Alzheimer-like changes in Tg 2576 A\u03b2PP-overexpressing mice. J Alzheimer\u2019s Dis 19:691\u2013704","journal-title":"J Alzheimer\u2019s Dis"},{"key":"1060_CR166","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.brainres.2008.10.029","volume":"1249","author":"T Watanabe","year":"2009","unstructured":"Watanabe T, Yamagata N, Takasaki K, Sano K, Hayakawa K, Katsurabayashi S, Egashira N, Mishima K, Iwasaki K, Fujiwara M (2009) Decreased acetylcholine release is correlated to memory impairment in the Tg2576 transgenic mouse model of Alzheimer\u2019s disease. Brain Res 1249:222\u2013228","journal-title":"Brain Res"},{"key":"1060_CR167","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.neuint.2009.03.007","volume":"55","author":"E Hellstrom-Lindahl","year":"2009","unstructured":"Hellstrom-Lindahl E, Viitanen M, Marutle A (2009) Comparison of A\u03b2 levels in the brain of familial and sporadic Alzheimer\u2019s disease. Neurochem Int 55:243\u2013252","journal-title":"Neurochem Int"},{"key":"1060_CR168","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1006\/exnr.2001.7819","volume":"173","author":"L Liu","year":"2002","unstructured":"Liu L, Ikonen S, Heikkinen T, Tapiola T, VanGroen T, Tanila H (2002) The effects of long-term treatment with metrifonate, cholinesterase inhibitor, on cholinergic activity, amyloid pathology, and cognitive function in APP and PS1 doubly transgenic mice. Exp Neurol 173:196\u2013204","journal-title":"Exp Neurol"},{"key":"1060_CR169","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1471-4159.2006.03769.x","volume":"97","author":"A Contestabile","year":"2006","unstructured":"Contestabile A, Fila T, Bartesaghi R, Contestabile A, Ciani E (2006) Choline acetyltransferase activity in brain of Ts65Dn mice, an animal model for Down\u2019s syndrome and related neurodegenerative diseases. J Neurochem 97:515\u2013526","journal-title":"J Neurochem"},{"key":"1060_CR170","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0197-4580(03)00122-2","volume":"25","author":"Y Ikarashi","year":"2004","unstructured":"Ikarashi Y, Hatigaya Y, Tomidokoro Y, Kanai M, Ikeda M, Matsubara E, Kawarabayashi T, Kuribara M, Younkin SG, Maruyama Y, Shoi M (2004) Decreased level of brain acetylcholine and memory disturbance in APPsw mice. Neurobiol Aging 25:483\u2013490","journal-title":"Neurobiol Aging"},{"key":"1060_CR171","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/0896-6273(95)90107-8","volume":"15","author":"KK Hsiao","year":"1995","unstructured":"Hsiao KK, Borchet DR, Olson K, Johannsdottir R, Kitt C, Yunis W, Xu S, Eckman C, Younkin S, Price D et al (1995) Age-related CNS disorder and early death in transgenic FVB\/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron 15:1203\u20131218","journal-title":"Neuron"},{"key":"1060_CR172","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.nbd.2009.12.023","volume":"38","author":"E Machova","year":"2010","unstructured":"Machova E, Rudajev V, Snyckova H, Koivisto H, Tanila H, Dolezal V (2010) Functional cholinergic damage develops with amyloid accumulation in young adult APPswe\/PS1dE9 transgenic mice. Neurobiol Dis 38:27\u201335","journal-title":"Neurobiol Dis"},{"key":"1060_CR173","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1023\/A:1020678912330","volume":"13","author":"M Gold","year":"1998","unstructured":"Gold M, Hauser RA, Chen MF (1998) Plasma thiamine deficiency associated with Alzheimer\u2019s disease but not Parkinson\u2019s disease. Met Brain Dis 13:43\u201353","journal-title":"Met Brain Dis"},{"key":"1060_CR174","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neurobiolaging.2009.01.005","volume":"32","author":"Q Zhang","year":"2011","unstructured":"Zhang Q, Yang G, Li W, Fa Z, Sun A, Luo J, Ke ZJ (2011) Thiamine deficiency increases \u03b2-secretase activity and accumulation of \u03b2-amyloid peptides. Neurobiol Aging 32:42\u201353","journal-title":"Neurobiol Aging"},{"key":"1060_CR175","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.exger.2010.11.032","volume":"46","author":"C Humpel","year":"2011","unstructured":"Humpel C (2011) Chronic mild cerebrovascular dysfunction as a cause for Alzheimer\u2019s disease? Exp Gerontol 46:225\u2013232","journal-title":"Exp Gerontol"},{"key":"1060_CR176","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/j.1471-4159.1973.tb07581.x","volume":"21","author":"CP Heinrich","year":"1973","unstructured":"Heinrich CP, Stadler H, Weiser H (1973) The effect of thiamine deficiency on the acetylcoenzyme A and acetylcholine levels in the rat brain. J Neurochem 21:1273\u20131281","journal-title":"J Neurochem"},{"key":"1060_CR177","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.neuint.2004.05.007","volume":"45","author":"P Bubber","year":"2004","unstructured":"Bubber P, Zj Ke, Gibson GE (2004) Tricarboxylic acid cycle enzymes following thiamine deficiency. Neurochem Int 45:1021\u20131028","journal-title":"Neurochem Int"},{"key":"1060_CR178","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.nbd.2007.08.014","volume":"29","author":"N Zhao","year":"2008","unstructured":"Zhao N, Zhong C, Wang Y, Zhao Y, Gong N, Zhou G, Xu T, Hong Z (2008) Impaired hippocampal neurogenesis is involved in cognitive dysfunction induced by thiamine deficiency at early pre-pathological lesion stage. Neurobiol Dis 29:176\u2013185","journal-title":"Neurobiol Dis"},{"key":"1060_CR179","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1749-6632.1982.tb31212.x","volume":"378","author":"A Plaitakis","year":"1982","unstructured":"Plaitakis A, Hwang EC, Van Woert MH, Szilagyi PI, Berl S (1982) Effect of thiamin deficiency on brain neurotransmitter systems. Ann NY Acad Sci 378:367\u2013381","journal-title":"Ann NY Acad Sci"},{"key":"1060_CR180","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0304-3940(99)00869-1","volume":"277","author":"DD Allen","year":"1999","unstructured":"Allen DD, Smith QR (1999) Blood-brain barrier choline transport in the senescent rat. Neurosci Lett 277:198\u2013202","journal-title":"Neurosci Lett"},{"key":"1060_CR181","first-page":"117","volume":"15","author":"RJ Wurtman","year":"1992","unstructured":"Wurtman RJ (1992) Choline metabolism as a basis for selective vulnerability of cholinergic neurons. TINS 15:117\u2013122","journal-title":"TINS"},{"key":"1060_CR182","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1111\/j.1471-4159.1973.tb06022.x","volume":"21","author":"HI Yamamura","year":"1973","unstructured":"Yamamura HI, Snyder SH (1973) High affinity transport of choline into synaptosomes of rat brain. J Neurochem 21:1355\u20131374","journal-title":"J Neurochem"},{"key":"1060_CR183","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2007.01.119","volume":"1145","author":"M Brock","year":"2007","unstructured":"Brock M, Nickel AC, Madziar B, Blusztajn JK, Berse B (2007) Differential regulation of the high affinity choline transporter and cholinergic locus by cAMP signaling pathways. Brain Res 1145:1\u201310","journal-title":"Brain Res"},{"key":"1060_CR184","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1126\/science.281.5378.794","volume":"281","author":"JK Blusztajn","year":"1998","unstructured":"Blusztajn JK (1998) Choline, a vital amine. Science 281:794\u2013795","journal-title":"Science"},{"key":"1060_CR185","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.brainres.2008.08.049","volume":"1237","author":"MJ Glenn","year":"2008","unstructured":"Glenn MJ, Kirby ED, Gibson EM, Wong-Goodrich SJ, Mellot TJ, Blusztajn JK, Williams CL (2008) Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats. Brain Res 1237:110\u2013123","journal-title":"Brain Res"},{"key":"1060_CR186","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.fct.2008.10.012","volume":"47","author":"C Liapi","year":"2009","unstructured":"Liapi C, Kyriakaki A, Zarros A, Al-Humadi H, Stolakis V, Gkrouzman E, Anifantaki F, Skandali N, Margaritis M, Tsakiris S (2009) Effect of adult-onset choline deprivation on the activities of acetylcholinesterase (Na+, K+)- and Mg2+ATPase in crucial rat brain regions. Food Chem Toxicol 47:82","journal-title":"Food Chem Toxicol"},{"key":"1060_CR187","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3945\/jn.109.116673","volume":"40","author":"C Pacelli","year":"2010","unstructured":"Pacelli C, Coluccia A, Grattagliano I, Cocco T, Petrosillo G, Paradies G, De Nitto E, Massaro A, Persichella M, Borraci P, Portincasa P, Carratu MR (2010) Dietary choline deprivation impairs rat brain mitochondrial function and behavioral phenotype. J Nutr 40:1072\u20131079","journal-title":"J Nutr"},{"key":"1060_CR188","doi-asserted-by":"crossref","first-page":"14670","DOI":"10.1073\/pnas.0903563106","volume":"106","author":"J Yao","year":"2009","unstructured":"Yao J, Irwin RW, Zhao L, Nilsen J, Hamilton RT, Brinton RD (2009) Mitochondrial bioenergetic deficit precedes Alzheimer\u2019s pathology in female mouse model of Alzheimer\u2019s disease. Proc Natl Acad Sci USA 106:14670\u201314675","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-013-1060-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-013-1060-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-013-1060-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T18:47:41Z","timestamp":1715366861000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-013-1060-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,16]]},"references-count":188,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["1060"],"URL":"https:\/\/doi.org\/10.1007\/s11064-013-1060-x","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,16]]}}}