{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:44:35Z","timestamp":1782906275878,"version":"3.54.5"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T00:00:00Z","timestamp":1387238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1007\/s11064-013-1224-8","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T17:10:31Z","timestamp":1387213831000},"page":"313-320","source":"Crossref","is-referenced-by-count":15,"title":["Evaluation of Potential Antidepressant-Like Activity of Chalcone-1203 in Various Murine Experimental Depressant Models"],"prefix":"10.1007","volume":"39","author":[{"given":"Li-Ping","family":"Guan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ming","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shui-Lian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,12,17]]},"reference":[{"key":"1224_CR1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0003-3472(73)80065-X","volume":"21","author":"J Archer","year":"1973","unstructured":"Archer J (1973) Tests for emotionality in rats and mice: a review. Anim Behav 21:205\u2013235","journal-title":"Anim Behav"},{"key":"1224_CR2","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.pbb.2008.02.014","volume":"89","author":"L An","year":"2008","unstructured":"An L, Zhang YZ, Jiang N, Liu XM, Zhao N, Yuan L, Li YF (2008) Role for serotonin in the antidepressant-like effect of a flavonoid extract of Xiaobuxin-Tang. Pharmacol Biochem Behav 89:572\u2013580","journal-title":"Pharmacol Biochem Behav"},{"key":"1224_CR3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jep.2008.01.012","volume":"117","author":"SK Bhattamisra","year":"2008","unstructured":"Bhattamisra SK, Khanna VK, Agrawal AK, Singh PN, Singh SK (2008) Antidepressant activity of standardised extract of Marsilea minuta Linn. J Ethnopharmacol 117:51\u201357","journal-title":"J Ethnopharmacol"},{"key":"1224_CR4","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0031-9384(86)90110-1","volume":"38","author":"F Borsini","year":"1986","unstructured":"Borsini F, Voltera G, Meli AA (1986) Dose the behavioral \u2018despair\u2019 test measure \u2018despair\u2019. Physiol Behav 38:385\u2013389","journal-title":"Physiol Behav"},{"key":"1224_CR5","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3109\/00498258309052228","volume":"13","author":"S Brown","year":"1983","unstructured":"Brown S, Griffiths LA (1983) Metabolism and excretion of butein, 2\u2032,3,4-trihydroxychalcone, 3-O-methyltutein, 4-O-methylbutein and 2\u2032,4\u2032,4-trihydroxychalcone in the rat. Xenobiotica 13:669\u2013682","journal-title":"Xenobiotica"},{"key":"1224_CR6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.jep.2004.09.033","volume":"96","author":"Y Chen","year":"2005","unstructured":"Chen Y, Kong LD, Xia X, Kung HF, Zhang L (2005) Behavioral and biochemical studies of total furocoumarins from seeds of Psoralea corylifolia in the forced swimming test in mice. J Ethnopharmacol 96:451\u2013459","journal-title":"J Ethnopharmacol"},{"key":"1224_CR7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0005-2760(98)00043-5","volume":"1392","author":"ZJ Cheng","year":"1998","unstructured":"Cheng ZJ, Kuo SC, Chan SC, Ko FN, Teng CM (1998) Antioxidant properties of butein isolated from Dalbergia odorifera. Biochim Biphys Acta 1392:291\u2013299","journal-title":"Biochim Biphys Acta"},{"key":"1224_CR8","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/0006-2952(85)90484-8","volume":"34","author":"W Commissiong","year":"1985","unstructured":"Commissiong W (1985) Monoamine metabolites: their relationship and lack of relationship to monoaminergic neuronal activity. Biochem Pharmacol 34:1127\u20131231","journal-title":"Biochem Pharmacol"},{"key":"1224_CR9","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0091-3057(97)00028-2","volume":"58","author":"TJ Connor","year":"1997","unstructured":"Connor TJ, Kelly JP, Leonard BE (1997) Forced swim test-induced neurochemical endocrine, and immune changes in the rat. Pharmacol Biochem Behav 58:961\u2013967","journal-title":"Pharmacol Biochem Behav"},{"key":"1224_CR10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0006-8993(86)90075-2","volume":"381","author":"PJ Elliott","year":"1986","unstructured":"Elliott PJ, Chan J, Parker YM (1986) Behavioral effects of neurotensin in the open field: structure activity studies. Brain Res 381:259\u2013265","journal-title":"Brain Res"},{"key":"1224_CR11","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.jep.2009.05.001","volume":"124","author":"PM Galdino","year":"2009","unstructured":"Galdino PM, Nascimento MV, Sampaio BL, Ferreira RN, Paula JR, Costa EA (2009) Antidepressant-like effect of Lafoensia pacari A. St.-Hil. Ethanolic extract and fractions in mice. J Ethnopharmacol 124:581\u2013585","journal-title":"J Ethnopharmacol"},{"key":"1224_CR12","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000118474","volume":"20","author":"RJ Haier","year":"1988","unstructured":"Haier RJ, Buchsbaum MS, DeMet E, Wu J (1988) Biological vulnerability to depression: replication of MAO and evoked potentials as risk factors. Neuropsychobiology 20:62\u201366","journal-title":"Neuropsychobiology"},{"key":"1224_CR13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neulet.2003.10.040","volume":"355","author":"MP Kaster","year":"2004","unstructured":"Kaster MP, Rosa AO, Rosso MM, Goulart EC, Santos AR, Rodrigues AL (2004) Adenosine administration produces an antidepressant-like effect in mice: evidence for the involvement of A1 and A2A receptors. Neurosci Lett 355:21\u201324","journal-title":"Neurosci Lett"},{"key":"1224_CR14","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.japna.2003.08.004","volume":"34","author":"HW Lee","year":"2004","unstructured":"Lee HW, Ji HY, Lee HI, Kim HK, Sohn DH, Kim YC, Chung HT, Lee HS (2004) Determination of butein in tat serum by high performance liquid chromatography. J Pharm Biomed Anal 34:227\u2013231","journal-title":"J Pharm Biomed Anal"},{"key":"1224_CR15","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ejphar.2006.01.005","volume":"532","author":"SH Lee","year":"2006","unstructured":"Lee SH, Seo GS, Kim JY, Jin XY, Kim H-D, Sohn DH (2006) Heme oxygenase 1 mediates anti-inflammatory effects of 2,4,6-tris(methoxymethoxy)chalcone. Eur J Pharmacol 532:178\u2013186","journal-title":"Eur J Pharmacol"},{"key":"1224_CR16","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1046\/j.1460-9568.2002.02400.x","volume":"16","author":"AC Linthorst","year":"2002","unstructured":"Linthorst AC, Penalva RG, Flachskamm C, Holsboer F, Reul JM (2002) Forced swim stress activates rat hippocampal serotonergic neurotransmission involving acorticotropin-releasing hormone receptor-dependent mechanism. Eur J Neurosci 16:2441\u20132452","journal-title":"Eur J Neurosci"},{"key":"1224_CR17","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/3218","volume":"4","author":"AD Lopez","year":"1998","unstructured":"Lopez AD, Murray CC (1998) The global burden of disease, 1990\u20132020. Nat Med 4:1241\u20131243","journal-title":"Nat Med"},{"key":"1224_CR18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejphar.2008.03.021","volume":"587","author":"DG Machado","year":"2008","unstructured":"Machado DG, Bettio LE, Cunha MP, Santos AR, Pizzolatti MG, Briqhente IM, Rodriques AL (2008) Antidepressant-like effect of rutin isolated from the ethanolic extract from Schinus molle L. in mice: evidence for the involvement of the serotonergic and noradrenergic systems. Eur J Pharmacol 587:163\u2013168","journal-title":"Eur J Pharmacol"},{"key":"1224_CR19","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0091-3057(95)02019-5","volume":"53","author":"H Miura","year":"1996","unstructured":"Miura H, Naoi M, Nakahara D, Ohta T, Nagatsu T (1996) Effects of moclobemide on forced-swimming stress and brain monoamine levels in mice. Pharmacol Biochem Behav 53:469\u2013475","journal-title":"Pharmacol Biochem Behav"},{"key":"1224_CR20","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1248\/bpb.26.474","volume":"26","author":"T Nakazawa","year":"2003","unstructured":"Nakazawa T, Yasuda T, Ueda J, Ohsawa K (2003) Antidepressant-like effects of apigenin and 2,4,5-trimethoxycin-namic acid from Perilla frutescens in the forced swimming test. Biol Pharm Bull 26:474\u2013480","journal-title":"Biol Pharm Bull"},{"key":"1224_CR21","first-page":"296","volume":"63","author":"A Paulke","year":"2008","unstructured":"Paulke A, N\u00f6ldner M, Schubert-Zsilavecz M, Wurqlics M (2008) St. John\u2019s wort flavonoids and their metabolites show antidepressant activity and accumulate in brain after multiple oral doses. Pharmazie 63:296\u2013302","journal-title":"Pharmazie"},{"key":"1224_CR22","unstructured":"Porsolt RD (1981). Behavioral despair test. In: Enna SJ, Malick JB and Richelson E (eds) Antidepressants: neurochemical, behavioral, and clinical perspectives. Raven Press, New York, pp 129\u2013139"},{"key":"1224_CR23","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1248\/bpb.29.1767","volume":"29","author":"H Sakakibara","year":"2006","unstructured":"Sakakibara H, Ishida K, Grundmann O, Nakajima J, Seo S, Butterweck V, Minami Y, Saito S, Kawai Y, Nakaya Y, Terao J (2006) Antidepressant effect of extracts from Ginkgo biloba leaves in behavioral models. Biol Pharm Bull 29:1767\u20131770","journal-title":"Biol Pharm Bull"},{"key":"1224_CR24","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0091-3057(92)90211-W","volume":"41","author":"R Schwarting","year":"1992","unstructured":"Schwarting R, Huston J (1992) Behavioral concomitants of regional changes in the brain\u2019s biogenic amines after apomorphine and amphetamine. Pharmacol Biochem Behav 41:675\u2013682","journal-title":"Pharmacol Biochem Behav"},{"key":"1224_CR25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","volume":"85","author":"L Steru","year":"1985","unstructured":"Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology 85:367\u2013370","journal-title":"Psychopharmacology"},{"issue":"suppl 4","key":"1224_CR26","first-page":"5","volume":"59","author":"SM Stahl","year":"1998","unstructured":"Stahl SM (1998) Basic psychopharmacology of antidepressants, part 1: antidepressants have seven distinct mech-anisms of action. J Clin Psychiatry 59(suppl 4):5\u201314","journal-title":"J Clin Psychiatry"},{"key":"1224_CR27","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1007\/s00044-011-9640-2","volume":"21","author":"X Sui","year":"2012","unstructured":"Sui X, Quan YC, Chang Y, Zhang RP, Xu YF, Guan LP (2012) Synthesis and studies on antidepressant activity 2\u2032,4\u2032,6\u2032-trihydroxychalcone derivatives. Med Chem Res 21:1290\u20131296","journal-title":"Med Chem Res"},{"key":"1224_CR28","first-page":"175","volume":"2","author":"Y Tian","year":"2010","unstructured":"Tian Y (2010) Research progress of clinical antidepressant drugs. J China Tradit Chin Med Inf 2:175","journal-title":"J China Tradit Chin Med Inf"},{"issue":"Suppl 13","key":"1224_CR29","first-page":"18","volume":"64","author":"MS Thase","year":"2003","unstructured":"Thase MS (2003) Evaluating antidepressant therapies: remission as the optimal outcome. J Clin Psychiatry 64(Suppl 13):18\u201325","journal-title":"J Clin Psychiatry"},{"key":"1224_CR30","doi-asserted-by":"crossref","first-page":"224","DOI":"10.4088\/JCP.v68n0207","volume":"68","author":"ME Thaes","year":"2007","unstructured":"Thaes ME, Corya SA, Osuntokun O, Case M, Henley DB, Sanger TM, Watson SB, Dub\u00e9 S (2007) A randomized, double-blind comparison of olanzapine\/fluoxetine combination, olanzapine, and fluoxetine in treatment-resistant major depressive disorder. J Clin Psychiatry 68:224\u2013226","journal-title":"J Clin Psychiatry"},{"key":"1224_CR31","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.pnpbp.2007.12.021","volume":"32","author":"WX Wang","year":"2008","unstructured":"Wang WX, Hu XY, Zhao ZY, Liu P, Hu Y, Zhou J, Zhou D, Wang Z, Guo D, Guo H (2008) Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice. Prog Neuro Psychopharmocol Biol Psychiatry 32:1179\u20131184","journal-title":"Prog Neuro Psychopharmocol Biol Psychiatry"},{"key":"1224_CR32","doi-asserted-by":"crossref","first-page":"11700","DOI":"10.1021\/bi991247f","volume":"38","author":"KA Winans","year":"1999","unstructured":"Winans KA, King DA, Rao V, Bertozzi CR (1999) A Chemically synthesized version of the insect antibacterial glycopeptide, diptericin disrupts bacterial membrane integrity. Biochemistry 38:11700\u201311710","journal-title":"Biochemistry"},{"key":"1224_CR33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00008877-200205000-00001","volume":"13","author":"P Willner","year":"2002","unstructured":"Willner P, Mitchell PJ (2002) The validity of animal models of predisposition to depression. Behav Pharmacol 13:169\u2013188","journal-title":"Behav Pharmacol"},{"key":"1224_CR34","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1211\/002235702658","volume":"55","author":"SW Woo","year":"2003","unstructured":"Woo SW, Lee SH, Kang HC, Paik EJ, Zhao YZ, Kim YC, Sohn DH (2003) Butein suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture. J Pharm Phamacol 55:347\u2013352","journal-title":"J Pharm Phamacol"},{"key":"1224_CR35","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.lfs.2008.01.007","volume":"82","author":"LT Yi","year":"2008","unstructured":"Yi LT, Li JM, Li YC, Pan Y, Xu Q, Kong LD (2008) Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin. Life Sci 82:741\u2013751","journal-title":"Life Sci"},{"key":"1224_CR36","first-page":"1129","volume":"23","author":"DH Zhao","year":"2011","unstructured":"Zhao DH, Sui X, YL QU, Yang LY, Wang X, Guan LP (2011) Synthesis and studies on antidepressant effect of 5, 7-dihydroxyflavanone derivatives. Asian J Chem 23:1129\u20131132","journal-title":"Asian J Chem"},{"key":"1224_CR37","first-page":"1115","volume":"21","author":"DH Zhao","year":"2010","unstructured":"Zhao DH, Zhang YZ, Zheng ZH (2010) Synthesis and studies on antidepressant effect of 2\u2032, 4\u2032-dihyoxylchalcone. Shi Zhen Med Mater Med Res 21:1115\u20131116","journal-title":"Shi Zhen Med Mater Med Res"},{"key":"1224_CR38","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1021\/jo102516a","volume":"76","author":"LM Zhao","year":"2011","unstructured":"Zhao LM, Jin HS, Wan LJ, Zhang LM (2011) General and highly -regioselective zinc-mediated prenylation of aldehydes and ketones. J Org Chem 76:1831\u20131837","journal-title":"J Org Chem"},{"key":"1224_CR39","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0006-8993(99)01214-7","volume":"824","author":"A Zangen","year":"1999","unstructured":"Zangen A, Overstreet D, Yadid Gal (1999) Increased catecholamine levels in specific brain regions of a rat model of depression: normalization by chronic antidepressant treatment. Brain Res 824:243\u2013250","journal-title":"Brain Res"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-013-1224-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-013-1224-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-013-1224-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T04:34:57Z","timestamp":1559363697000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-013-1224-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,17]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["1224"],"URL":"https:\/\/doi.org\/10.1007\/s11064-013-1224-8","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,17]]}}}