{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T16:48:45Z","timestamp":1789145325418,"version":"build-2803163510"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2015,5,10]],"date-time":"2015-05-10T00:00:00Z","timestamp":1431216000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1007\/s11064-015-1595-0","type":"journal-article","created":{"date-parts":[[2015,5,9]],"date-time":"2015-05-09T00:11:37Z","timestamp":1431130297000},"page":"1303-1310","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Spatial Learning Requires mGlu5 Signalling in the Dorsal Hippocampus"],"prefix":"10.1007","volume":"40","author":[{"given":"Shawn Zheng Kai","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina E.","family":"Ganella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alec Lindsay Ward","family":"Dick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhodie R.","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Ong-Palsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross A. D.","family":"Bathgate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jee Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,5,10]]},"reference":[{"issue":"6407","key":"1595_CR1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","volume":"361","author":"TV Bliss","year":"1993","unstructured":"Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361(6407):31\u201339","journal-title":"Nature"},{"issue":"4","key":"1595_CR2","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.pbb.2011.04.010","volume":"100","author":"C Riaza Bermudo-Soriano","year":"2012","unstructured":"Riaza Bermudo-Soriano C, Perez-Rodriguez MM, Vaquero-Lorenzo C, Baca-Garcia E (2012) New perspectives in glutamate and anxiety. Pharmacol Biochem Behav 100(4):752\u2013774","journal-title":"Pharmacol Biochem Behav"},{"issue":"3","key":"1595_CR3","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1101\/lm.7.3.170","volume":"7","author":"PV Nguyen","year":"2000","unstructured":"Nguyen PV, Abel T, Kandel ER, Bourtchouladze R (2000) Strain-dependent differences in LTP and hippocampus-dependent memory in inbred mice. Learn Mem 7(3):170\u2013179","journal-title":"Learn Mem"},{"issue":"5","key":"1595_CR4","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1152\/jn.2000.84.5.2484","volume":"84","author":"PV Nguyen","year":"2000","unstructured":"Nguyen PV, Duffy SN, Young JZ (2000) Differential maintenance and frequency-dependent tuning of LTP at hippocampal synapses of specific strains of inbred mice. J Neurophysiol 84(5):2484\u20132493","journal-title":"J Neurophysiol"},{"key":"1595_CR5","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0165-6147(91)90527-Y","volume":"12","author":"I Izquierdo","year":"1991","unstructured":"Izquierdo I (1991) Role of NMDA receptors in memory. Trends Pharmacol Sci 12:128\u2013129","journal-title":"Trends Pharmacol Sci"},{"issue":"3","key":"1595_CR6","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.3390\/molecules16032097","volume":"16","author":"RM Cleva","year":"2011","unstructured":"Cleva RM, Olive MF (2011) Positive allosteric modulators of type 5 metabotropic glutamate receptors (mGluR5) and their therapeutic potential for the treatment of CNS disorders. Molecules 16(3):2097\u20132106","journal-title":"Molecules"},{"key":"1595_CR7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1146\/annurev.pharmtox.011008.145533","volume":"50","author":"CM Niswender","year":"2010","unstructured":"Niswender CM, Conn PJ (2010) Metabotropic glutamate receptors: physiology, pharmacology, and disease. Ann Rev Pharmacol Toxicol 50:295\u2013322","journal-title":"Ann Rev Pharmacol Toxicol"},{"issue":"1","key":"1595_CR8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3940(93)90227-C","volume":"163","author":"R Shigemoto","year":"1993","unstructured":"Shigemoto R, Nomura S, Ohishi H, Sugihara H, Nakanishi S, Mizuno N (1993) Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain. Neurosci Lett 163(1):53\u201357","journal-title":"Neurosci Lett"},{"issue":"4","key":"1595_CR9","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.pbb.2011.03.015","volume":"100","author":"JR Duncan","year":"2012","unstructured":"Duncan JR, Lawrence AJ (2012) The role of metabotropic glutamate receptors in addiction: evidence from preclinical models. Pharmacol Biochem Behav 100(4):811\u2013824","journal-title":"Pharmacol Biochem Behav"},{"issue":"12","key":"1595_CR10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.tips.2009.09.008","volume":"30","author":"MK Bird","year":"2009","unstructured":"Bird MK, Lawrence AJ (2009) The promiscuous mGlu5 receptor: a range of partners for therapeutic possibilities? Trends Pharmacol Sci 30(12):617\u2013623","journal-title":"Trends Pharmacol Sci"},{"key":"1595_CR11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.drugalcdep.2014.01.017","volume":"137","author":"MK Bird","year":"2014","unstructured":"Bird MK, Lohmann P, West B, Brown RM, Kirchhoff J, Raymond CR, Lawrence AJ (2014) The mGlu5 receptor regulates extinction of cocaine-driven behaviours. Drug Alc Dep. 137:83\u201389","journal-title":"Drug Alc Dep."},{"issue":"13","key":"1595_CR12","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1523\/JNEUROSCI.17-13-05196.1997","volume":"17","author":"YM Lu","year":"1997","unstructured":"Lu YM, Jia Z, Janus C, Henderson JT, Gerlai R, Wojtowicz JM, Roder JC (1997) Mice lacking metabotropic glutamate receptor 5 show impaired learning and reduced CA1 long-term potentiation (LTP) but normal CA3 LTP. J Neurosci 17(13):5196\u20135205","journal-title":"J Neurosci"},{"issue":"9","key":"1595_CR13","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1038\/npp.2009.30","volume":"34","author":"JE Ayala","year":"2009","unstructured":"Ayala JE, Chen Y, Banko JL, Sheffler DJ, Williams R, Telk AN, Watson NL, Xiang Z, Zhang Y, Jones PJ, Lindsley CW, Olive MF, Conn PJ (2009) mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning. Neuropsychopharmacology 34(9):2057\u20132071","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"1595_CR14","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s00213-005-2211-9","volume":"179","author":"TM Ballard","year":"2005","unstructured":"Ballard TM, Woolley ML, Prinssen E, Huwyler J, Porter R, Spooren W (2005) The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison. Psychopharmacology 179(1):218\u2013229","journal-title":"Psychopharmacology"},{"issue":"1","key":"1595_CR15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1124\/pr.59.1.3","volume":"59","author":"H Car","year":"2007","unstructured":"Car H, Stefaniuk R, Wisniewska RJ (2007) Effect of MPEP in morris water maze in adult and old rats. Pharmacol Rep 59(1):88\u201393","journal-title":"Pharmacol Rep"},{"issue":"1","key":"1595_CR16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0014-2999(03)01935-6","volume":"473","author":"JJ Anderson","year":"2003","unstructured":"Anderson JJ, Bradbury MJ, Giracello DR, Chapman DF, Holtz G, Roppe J, King C, Cosford ND, Varney MA (2003) In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). Eur J Pharmacol 473(1):35\u201340","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"1595_CR17","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1124\/jpet.102.040618","volume":"303","author":"JJ Anderson","year":"2002","unstructured":"Anderson JJ, Rao SP, Rowe B, Giracello DR, Holtz G, Chapman DF, Tehrani L, Bradbury MJ, Cosford ND, Varney MA (2002) [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization. J Pharmacol Exp Ther 303(3):1044\u20131051","journal-title":"J Pharmacol Exp Ther"},{"issue":"12","key":"1595_CR18","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s00702-008-0098-4","volume":"115","author":"A Gravius","year":"2008","unstructured":"Gravius A, Dekundy A, Nagel J, Mor\u00e8 L, Pietraszek M, Danysz W (2008) Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats. J Neural Trans 115(12):1609\u20131619","journal-title":"J Neural Trans"},{"issue":"4","key":"1595_CR19","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1006\/meth.1998.0593","volume":"14","author":"B Sauer","year":"1998","unstructured":"Sauer B (1998) Inducible gene targeting in mice using the Cre\/lox system. Methods 14(4):381\u2013392","journal-title":"Methods"},{"issue":"4","key":"1595_CR20","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1073\/pnas.81.4.1026","volume":"81","author":"RH Hoess","year":"1984","unstructured":"Hoess RH, Abremski K (1984) Interaction of the bacteriophage P1 recombinase Cre with the recombining site loxP. Proc Natl Acad Sci (USA) 81(4):1026\u20131029","journal-title":"Proc Natl Acad Sci (USA)"},{"issue":"5","key":"1595_CR21","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1037\/0735-7044.117.5.1044","volume":"117","author":"I Lee","year":"2003","unstructured":"Lee I, Kesner RP (2003) Differential roles of dorsal hippocampal subregions in spatial working memory with short versus intermediate delay. Behav Neurosci 117(5):1044\u20131053","journal-title":"Behav Neurosci"},{"issue":"12","key":"1595_CR22","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1523\/JNEUROSCI.5716-08.2009","volume":"29","author":"J Xu","year":"2009","unstructured":"Xu J, Zhu Y, Contractor A, Heinemann SF (2009) mGluR5 has a critical role in inhibitory learning. J Neurosci 29(12):3676\u20133684","journal-title":"J Neurosci"},{"issue":"7","key":"1595_CR23","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/gt.2012.83","volume":"20","author":"DE Ganella","year":"2013","unstructured":"Ganella DE, Callander GE, Ma S, Bye CR, Gundlach AL, Bathgate RAD (2013) Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus. Gene Ther 20(7):703\u2013716","journal-title":"Gene Ther"},{"issue":"12","key":"1595_CR24","doi-asserted-by":"crossref","first-page":"e15707","DOI":"10.1371\/journal.pone.0015707","volume":"5","author":"S Guggenhuber","year":"2010","unstructured":"Guggenhuber S, Monory K, Lutz B, Klugmann M (2010) AAV vector-mediated overexpression of CB1 cannabinoid receptor in pyramidal neurons of the hippocampus protects against seizure-induced excitoxicity. PLoS ONE 5(12):e15707","journal-title":"PLoS ONE"},{"issue":"5","key":"1595_CR25","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/mt.2009.44","volume":"17","author":"T Kiyota","year":"2009","unstructured":"Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T (2009) AAV1\/2-mediated CNS gene delivery of dominant-negative ccl2 mutant suppresses gliosis, [beta]-amyloidosis, and learning impairment of APP\/PS1 mice. Mol Ther 17(5):803\u2013809","journal-title":"Mol Ther"},{"issue":"2","key":"1595_CR26","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1006\/mthe.2002.0659","volume":"6","author":"MR Veldwijk","year":"2002","unstructured":"Veldwijk MR, Topaly J, Laufs S, Hengge UR, Wenz F, Zeller WJ, Fruehauf S (2002) Development and optimization of a real-time quantitative PCR-based method for the titration of AAV-2 vector stocks. Mol Ther 6(2):272\u2013278","journal-title":"Mol Ther"},{"issue":"1","key":"1595_CR27","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0196-9781(86)90076-8","volume":"7","author":"RE Watson Jr","year":"1986","unstructured":"Watson RE Jr, Wiegand SJ, Clough RW, Hoffman GE (1986) Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology. Peptides 7(1):155\u2013159","journal-title":"Peptides"},{"issue":"15","key":"1595_CR28","doi-asserted-by":"crossref","first-page":"e115","DOI":"10.1093\/nar\/gks596","volume":"40","author":"A Untergrasser","year":"2012","unstructured":"Untergrasser A, Cutcutache I, Koressaar T, Ye J, Faircloth BC, Remm M, Rozen SG (2012) Primer3: new capabilities and interfaces. Nucleic Acids Res 40(15):e115","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"1595_CR29","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1093\/cercor\/bhp159","volume":"20","author":"CS McPherson","year":"2010","unstructured":"McPherson CS, Mantamadiotis T, Tan S-S, Lawrence AJ (2010) Deletion of CREB1 from the dorsal telencephalon reduces motivational properties of cocaine. Cereb Cortex 20(4):941\u2013952","journal-title":"Cereb Cortex"},{"issue":"4","key":"1595_CR30","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25(4):402\u2013408","journal-title":"Methods"},{"issue":"6","key":"1595_CR31","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","volume":"3","author":"TD Schmittgen","year":"2008","unstructured":"Schmittgen TD, Livak KJ (2008) Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3(6):1101\u20131108","journal-title":"Nat Protoc"},{"issue":"1","key":"1595_CR32","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","volume":"36","author":"R D\u2019Hooge","year":"2001","unstructured":"D\u2019Hooge R, De Deyn PP (2001) Applications of the Morris water maze in the study of learning and memory. Brain Res Rev 36(1):60\u201390","journal-title":"Brain Res Rev"},{"issue":"1","key":"1595_CR33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.nlm.2011.08.009","volume":"97","author":"H Gerstein","year":"2012","unstructured":"Gerstein H, O\u2019Riordan K, Osting S, Schwarz M, Burger C (2012) Rescue of synaptic plasticity and spatial learning deficits in the hippocampus of Homer1 knockout mice by recombinant Adeno-associated viral gene delivery of Homer1c. Neurobiol Learn Mem 97(1):17\u201329","journal-title":"Neurobiol Learn Mem"},{"issue":"9","key":"1595_CR34","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.1073\/pnas.96.9.5280","volume":"96","author":"ME Bach","year":"1999","unstructured":"Bach ME, Barad M, Son H, Zhuo M, Lu YF, Shih R, Mansuy I, Hawkins RD, Kandel ER (1999) Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway. Proc Natl Acad Sci (USA) 96(9):5280\u20135285","journal-title":"Proc Natl Acad Sci (USA)"},{"issue":"5","key":"1595_CR35","doi-asserted-by":"crossref","first-page":"e2155","DOI":"10.1371\/journal.pone.0002155","volume":"3","author":"A Bikbaev","year":"2008","unstructured":"Bikbaev A, Neyman S, Ngomba RT, Conn PJ, Nicoletti F, Manahan-Vaughan D (2008) MGluR5 mediates the interaction between late-LTP, network activity, and learning. PLoS ONE 3(5):e2155","journal-title":"PLoS ONE"},{"key":"1595_CR36","first-page":"12","volume":"1\u20132","author":"W Francesconi","year":"1022","unstructured":"Francesconi W, Cammalleri M (1022) Sanna PP (2004) The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region. Brain Res 1\u20132:12\u201318","journal-title":"Brain Res"},{"issue":"2","key":"1595_CR37","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/S0959-4388(00)00194-X","volume":"11","author":"T Abel","year":"2001","unstructured":"Abel T, Lattal KM (2001) Molecular mechanisms of memory acquisition, consolidation and retrieval. Curr Opin Neurobiol 11(2):180\u2013187","journal-title":"Curr Opin Neurobiol"},{"issue":"6","key":"1595_CR38","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1046\/j.1471-4159.2001.00369.x","volume":"77","author":"N Janssens","year":"2001","unstructured":"Janssens N, Lesage ASJ (2001) Glutamate receptor subunit expression in primary neuronal and secondary glial cultures. J Neurochem 77(6):1457\u20131474","journal-title":"J Neurochem"},{"issue":"2\u20133","key":"1595_CR39","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1101\/lm.3.2-3.197","volume":"3","author":"KL Thomas","year":"1996","unstructured":"Thomas KL, Davis S, Hunt SP, Laroche S (1996) Alterations in the expression of specific glutamate receptor subunits following hippocampal LTP in vivo. Learn Mem 3(2\u20133):197\u2013208","journal-title":"Learn Mem"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-015-1595-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-015-1595-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-015-1595-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T17:27:06Z","timestamp":1566667626000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-015-1595-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,10]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["1595"],"URL":"https:\/\/doi.org\/10.1007\/s11064-015-1595-0","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,10]]}}}