{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:20:30Z","timestamp":1791274830510,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T00:00:00Z","timestamp":1455148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81400961"],"award-info":[{"award-number":["81400961"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1007\/s11064-016-1864-6","type":"journal-article","created":{"date-parts":[[2016,2,11]],"date-time":"2016-02-11T18:56:59Z","timestamp":1455217019000},"page":"1516-1526","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Neuroprotective Effects of Poly(ADP-ribose)polymerase Inhibitor Olaparib in Transient Cerebral Ischemia"],"prefix":"10.1007","volume":"41","author":[{"given":"Fei","family":"Teng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhui","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingjing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,2,11]]},"reference":[{"issue":"9834","key":"1864_CR1","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1016\/S0140-6736(12)60768-5","volume":"379","author":"Group IST, Sandercock P, Wardlaw JM, et al","year":"2012","unstructured":"Group IST, Sandercock P, Wardlaw JM et al (2012) The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6\u00a0h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial. Lancet 379(9834):2352\u20132363","journal-title":"Lancet"},{"issue":"9859","key":"1864_CR2","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","volume":"380","author":"R Lozano","year":"2012","unstructured":"Lozano R, Naghavi M, Foreman K et al (2012) Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2095\u20132128","journal-title":"Lancet"},{"issue":"9859","key":"1864_CR3","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","volume":"380","author":"CJ Murray","year":"2012","unstructured":"Murray CJ, Vos T, Lozano R et al (2012) Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990\u20132010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380(9859):2197\u20132223","journal-title":"Lancet"},{"issue":"5","key":"1864_CR4","doi-asserted-by":"crossref","first-page":"636","DOI":"10.2174\/1871527314666150430162841","volume":"14","author":"E Gerace","year":"2015","unstructured":"Gerace E, Pellegrini-Giampietro DE, Moroni F, Mannaioni G (2015) Poly(ADP-ribose)polymerase 1 (PARP-1) activation and Ca(2\u00a0+) permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) channels in post-ischemic brain damage: new therapeutic opportunities? CNS Neurol Disord: Drug Targets 14(5):636\u2013646","journal-title":"CNS Neurol Disord: Drug Targets"},{"issue":"1","key":"1864_CR5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.expneurol.2010.08.023","volume":"226","author":"T Ishrat","year":"2010","unstructured":"Ishrat T, Sayeed I, Atif F, Hua F, Stein DG (2010) Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases. Exp Neurol 226(1):183\u2013190","journal-title":"Exp Neurol"},{"issue":"9834","key":"1864_CR6","doi-asserted-by":"crossref","first-page":"2364","DOI":"10.1016\/S0140-6736(12)60738-7","volume":"379","author":"JM Wardlaw","year":"2012","unstructured":"Wardlaw JM, Murray V, Berge E, del Zoppo G, Sandercock P, Lindley RL, Cohen G (2012) Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis. Lancet 379(9834):2364\u20132372","journal-title":"Lancet"},{"key":"1864_CR7","doi-asserted-by":"crossref","first-page":"515716","DOI":"10.1155\/2014\/515716","volume":"2014","author":"A Majid","year":"2014","unstructured":"Majid A (2014) Neuroprotection in stroke: past, present, and future. ISRN Neurol 2014:515716","journal-title":"ISRN Neurol"},{"issue":"3","key":"1864_CR8","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/ana.20741","volume":"59","author":"VE O\u2019Collins","year":"2006","unstructured":"O\u2019Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW (2006) 1,026 experimental treatments in acute stroke. Ann Neurol 59(3):467\u2013477","journal-title":"Ann Neurol"},{"issue":"3","key":"1864_CR9","first-page":"156","volume":"43","author":"R Strosznajder","year":"2005","unstructured":"Strosznajder R, Gadamski R, Walski M (2005) Inhibition of poly(ADP-ribose) polymerase activity protects hippocampal cells against morphological and ultrastructural alteration evoked by ischemia-reperfusion injury. Folia Neuropathol 43(3):156\u2013165","journal-title":"Folia Neuropathol"},{"issue":"3\u20134","key":"1864_CR10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vph.2010.06.003","volume":"53","author":"RK Sodhi","year":"2010","unstructured":"Sodhi RK, Singh N, Jaggi AS (2010) Poly(ADP-ribose) polymerase-1 (PARP-1) and its therapeutic implications. Vascul Pharmacol 53(3\u20134):77\u201387","journal-title":"Vascul Pharmacol"},{"issue":"1","key":"1864_CR11","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.coph.2007.10.005","volume":"8","author":"F Moroni","year":"2008","unstructured":"Moroni F (2008) Poly(ADP-ribose)polymerase 1 (PARP-1) and postischemic brain damage. Curr Opin Pharmacol 8(1):96\u2013103","journal-title":"Curr Opin Pharmacol"},{"issue":"8","key":"1864_CR12","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1111\/bph.12416","volume":"171","author":"AA Fatokun","year":"2014","unstructured":"Fatokun AA, Dawson VL, Dawson TM (2014) Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities. Br J Pharmacol 171(8):2000\u20132016","journal-title":"Br J Pharmacol"},{"issue":"167","key":"1864_CR13","doi-asserted-by":"crossref","first-page":"ra20","DOI":"10.1126\/scisignal.2000902","volume":"4","author":"Y Wang","year":"2011","unstructured":"Wang Y, Kim NS, Haince JF, Kang HC, David KK, Andrabi SA, Poirier GG, Dawson VL, Dawson TM (2011) Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci Signal 4(167):ra20","journal-title":"Sci Signal"},{"issue":"10","key":"1864_CR14","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/nm1097-1089","volume":"3","author":"MJ Eliasson","year":"1997","unstructured":"Eliasson MJ, Sampei K, Mandir AS, Hurn PD, Traystman RJ, Bao J, Pieper A, Wang ZQ, Dawson TM, Snyder SH, Dawson VL (1997) Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia. Nat Med 3(10):1089\u20131095","journal-title":"Nat Med"},{"issue":"11","key":"1864_CR15","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1097\/00004647-199711000-00002","volume":"17","author":"M Endres","year":"1997","unstructured":"Endres M, Wang ZQ, Namura S, Waeber C, Moskowitz MA (1997) Ischemic brain injury is mediated by the activation of poly(ADP-ribose)polymerase. J Cereb Blood Flow Metab 17(11):1143\u20131151","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"1864_CR16","first-page":"811","volume":"59","author":"S Hendryk","year":"2008","unstructured":"Hendryk S, Czuba ZP, Jedrzejowska-Szypulka H, Szliszka E, Phillips VA, Threadgill MD, Krol W (2008) Influence of 5-aminoisoquinolin-1-one (5-AIQ) on neutrophil chemiluminescence in rats with transient and prolonged focal cerebral ischemia and after reperfusion. J Physiol Pharmacol 59(4):811\u2013822","journal-title":"J Physiol Pharmacol"},{"issue":"4","key":"1864_CR17","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/jcbfm.2009.9","volume":"29","author":"TM Kauppinen","year":"2009","unstructured":"Kauppinen TM, Suh SW, Berman AE, Hamby AM, Swanson RA (2009) Inhibition of poly(ADP-ribose) polymerase suppresses inflammation and promotes recovery after ischemic injury. J Cereb Blood Flow Metab 29(4):820\u2013829","journal-title":"J Cereb Blood Flow Metab"},{"issue":"5","key":"1864_CR18","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1111\/j.1476-5381.2011.01666.x","volume":"165","author":"F Moroni","year":"2012","unstructured":"Moroni F, Cozzi A, Chiarugi A, Formentini L, Camaioni E, Pellegrini-Giampietro DE, Chen Y, Liang S, Zaleska MM, Gonzales C, Wood A, Pellicciari R (2012) Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase. Br J Pharmacol 165(5):1487\u20131500","journal-title":"Br J Pharmacol"},{"key":"1864_CR19","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.expneurol.2013.07.007","volume":"248","author":"F Teng","year":"2013","unstructured":"Teng F, Beray-Berthat V, Coqueran B, Lesbats C, Kuntz M, Palmier B, Garraud M, Bedfert C, Slane N, B\u00e9r\u00e9zowski V, Szeremeta F, Hachani J, Scherman D, Plotkine M, Doan BT, Marchand-Leroux C, Margaill I (2013) Prevention of rt-PA induced blood-brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice. Exp Neurol 248:416\u2013428","journal-title":"Exp Neurol"},{"issue":"2","key":"1864_CR20","doi-asserted-by":"crossref","first-page":"107","DOI":"10.5152\/jtgga.2015.15029","volume":"16","author":"CK Bose","year":"2015","unstructured":"Bose CK, Basu N (2015) PARP inhibitors and more. J Turk Ger Gynecol Assoc 16(2):107\u2013110","journal-title":"J Turk Ger Gynecol Assoc"},{"issue":"8","key":"1864_CR21","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1517\/14740338.2015.1045875","volume":"14","author":"S Lheureux","year":"2015","unstructured":"Lheureux S, Bowering V, Karakasis K, Oza AM (2015) Safety evaluation of olaparib for treating ovarian cancer. Expert Opin Drug Saf 14(8):1305\u20131316","journal-title":"Expert Opin Drug Saf"},{"key":"1864_CR22","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.neuropharm.2015.06.002","volume":"97","author":"M Frechou","year":"2015","unstructured":"Frechou M, Zhang S, Liere P, Delespierre B, Soyed N, Pianos A, Schumacher M, Mattern C, Guennoun R (2015) Intranasal delivery of progesterone after transient ischemic stroke decreases mortality and provides neuroprotection. Neuropharmacology 97:394\u2013403","journal-title":"Neuropharmacology"},{"issue":"44","key":"1864_CR23","doi-asserted-by":"crossref","first-page":"17079","DOI":"10.1073\/pnas.0806092105","volume":"105","author":"S Rottenberg","year":"2008","unstructured":"Rottenberg S, Jaspers JE, Kersbergen A, van der Burg E, Nygren AO, Zander SA, Derksen PW, de Bruin M, Zevenhoven J, Lau A, Boulter R, Cranston A, O\u2019Connor MJ, Martin NM, Borst P, Jonkers J (2008) High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc Natl Acad Sci USA 105(44):17079\u201317084","journal-title":"Proc Natl Acad Sci USA"},{"issue":"12","key":"1864_CR24","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nrd3868","volume":"11","author":"JL Riffell","year":"2012","unstructured":"Riffell JL, Lord CJ, Ashworth A (2012) Tankyrase-targeted therapeutics: expanding opportunities in the PARP family. Nat Rev Drug Discov 11(12):923\u2013936","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"1864_CR25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejphar.2008.04.013","volume":"588","author":"M Haddad","year":"2008","unstructured":"Haddad M, Beray-Berthat V, Coqueran B, Palmier B, Szabo C, Plotkine M, Margaill I (2008) Reduction of hemorrhagic transformation by PJ34, a poly(ADP-ribose)polymerase inhibitor, after permanent focal cerebral ischemia in mice. Eur J Pharmacol 588(1):52\u201357","journal-title":"Eur J Pharmacol"},{"key":"1864_CR26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/01.STR.23.2.267","volume":"23","author":"F Wahl","year":"1992","unstructured":"Wahl F, Allix M, Plotkine M, Boulu RG (1992) Neurological and behavioral outcomes of focal cerebral ischemia in rats. Stroke 23:267\u2013272","journal-title":"Stroke"},{"key":"1864_CR27","doi-asserted-by":"crossref","first-page":"882","DOI":"10.3171\/jns.1985.62.6.0882","volume":"62","author":"ED Hall","year":"1985","unstructured":"Hall ED (1985) High-dose glucocorticoid treatment improves neurological recovery in head-injured mice. J Neurosurg 62:882\u2013887","journal-title":"J Neurosurg"},{"key":"1864_CR28","volume-title":"The mouse brain in stereotaxic coordinates","author":"G Paxinos","year":"2001","unstructured":"Paxinos G, Franklin KBJ (2001) The mouse brain in stereotaxic coordinates, 2nd edn. Academic Press, San Diego","edition":"2"},{"issue":"2","key":"1864_CR29","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.expneurol.2012.08.005","volume":"238","author":"M Amki El","year":"2012","unstructured":"El Amki M, Lerouet D, Coqueran B, Curis E, Orset C, Vivien D, Plotkine M, Marchand-Leroux C, Margaill I (2012) Experimental modeling of recombinant tissue plasminogen activator effects after ischemic stroke. Exp Neurol 238(2):138\u2013144","journal-title":"Exp Neurol"},{"issue":"2","key":"1864_CR30","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0014-4886(03)00367-4","volume":"184","author":"JY Couturier","year":"2003","unstructured":"Couturier JY, Ding-Zhou L, Croci N, Plotkine M, Margaill I (2003) 3-Aminobenzamide reduces brain infarction and neutrophil infiltration after transient focal cerebral ischemia in mice. Exp Neurol 184(2):973\u2013980","journal-title":"Exp Neurol"},{"issue":"7","key":"1864_CR31","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1111\/j.1460-9568.2011.07843.x","volume":"34","author":"JC Copin","year":"2011","unstructured":"Copin JC, Bengualid DJ, Da Silva RF, Kargiotis O, Schaller K, Gasche Y (2011) Recombinant tissue plasminogen activator induces blood-brain barrier breakdown by a matrix metalloproteinase-9-independent pathway after transient focal cerebral ischemia in mouse. Eur J Neurosci 34(7):1085\u20131092","journal-title":"Eur J Neurosci"},{"issue":"1","key":"1864_CR32","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/jcbfm.2014.167","volume":"35","author":"S Rom","year":"2015","unstructured":"Rom S, Zuluaga-Ramirez V, Dykstra H, Reichenbach NL, Ramirez SH, Persidsky Y (2015) Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions. J Cereb Blood Flow Metab 35(1):28\u201336","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"1864_CR33","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1124\/jpet.104.066944","volume":"310","author":"A Iwashita","year":"2004","unstructured":"Iwashita A, Tojo N, Matsuura S, Yamazaki S, Kamijo K, Ishida J, Yamamoto H, Hattori K, Matsuoka N, Mutoh S (2004) A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. J Pharmacol Exp Ther 310(2):425\u2013436","journal-title":"J Pharmacol Exp Ther"},{"key":"1864_CR34","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0006-8993(99)01335-9","volume":"829","author":"K Takahashi","year":"1999","unstructured":"Takahashi K, Pieper AA, Croul SE, Zhang J, Snyder SH, Greenberg JH (1999) Posttreatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia. Brain Res 829:46\u201354","journal-title":"Brain Res"},{"key":"1864_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrgentox.2015.02.006","volume":"782","author":"E Yamamura","year":"2015","unstructured":"Yamamura E, Muto S, Yamada K, Sato Y, Iwase Y, Uno Y (2015) Chromosomal damage and micronucleus induction by MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor: evidence for a non-DNA-reactive mode of action. Mutat Res, Genet Toxicol Environ Mutagen 782:1\u20138","journal-title":"Mutat Res, Genet Toxicol Environ Mutagen"},{"issue":"1","key":"1864_CR36","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1111\/j.1460-9568.2012.08116.x","volume":"36","author":"E Gerace","year":"2012","unstructured":"Gerace E, Scartabelli T, Formentini L, Landucci E, Moroni F, Chiarugi A, Pellegrini-Giampietro DE (2012) Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance. Eur J Neurosci 36(1):1993\u20132005","journal-title":"Eur J Neurosci"},{"issue":"2","key":"1864_CR37","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1056\/NEJMoa0900212","volume":"361","author":"PC Fong","year":"2009","unstructured":"Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, Mortimer P, Swaisland H, Lau A, O\u2019Connor MJ, Ashworth A, Carmichael J, Kaye SB, Schellens JH, de Bono JS (2009) Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 361(2):123\u2013134","journal-title":"N Engl J Med"},{"issue":"8","key":"1864_CR38","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/bjc.2011.382","volume":"105","author":"M Javle","year":"2011","unstructured":"Javle M, Curtin NJ (2011) The role of PARP in DNA repair and its therapeutic exploitation. Br J Cancer 105(8):1114\u20131122","journal-title":"Br J Cancer"},{"key":"1864_CR39","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.1200\/JCO.2009.26.9589","volume":"28","author":"PC Fong","year":"2009","unstructured":"Fong PC, Yap TA, Boss DS, Carden CP, Mergui-Roelvink M, Gourley C, De Greve J, Lubinski J, Shanley S, Messiou C, A\u2019Hern R, Tutt A, Ashworth A, Stone J, Carmichael J, Schellens JH, de Bono JS, Kaye SB (2009) Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum free interval. J Clin Oncol 28:2512\u20132519","journal-title":"J Clin Oncol"},{"key":"1864_CR40","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nrclinonc.2011.42","volume":"8","author":"MD Forster","year":"2011","unstructured":"Forster MD, Dedes KJ, Sandhu S, Frentzas S, Kristeleit R, Ashworth A, Poole CJ, Weigelt B, Kaye SB, Molife LR (2011) Treatment with olaparib in a patient with PTEN-deficient endometrioid endometrial cancer. Nat Rev Clin Oncol 8:302\u2013306","journal-title":"Nat Rev Clin Oncol"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-016-1864-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-016-1864-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-016-1864-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-016-1864-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:39:59Z","timestamp":1559349599000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-016-1864-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,11]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["1864"],"URL":"https:\/\/doi.org\/10.1007\/s11064-016-1864-6","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,11]]}}}