{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:45:17Z","timestamp":1762101917203},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T00:00:00Z","timestamp":1474588800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Georgia Gwinnett College STEM Grant Initiative"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1007\/s11064-016-2068-9","type":"journal-article","created":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T04:04:45Z","timestamp":1474603485000},"page":"3356-3363","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Saturation Binding of Nicotine to Synthetic Neuromelanin Demonstrated by Fluorescence Spectroscopy"],"prefix":"10.1007","volume":"41","author":[{"given":"Robert L.","family":"Haining","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Travis M.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aubrey","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,9,23]]},"reference":[{"issue":"17","key":"2068_CR1","doi-asserted-by":"publisher","first-page":"S327","DOI":"10.1002\/mds.21684","volume":"22","author":"A Lees","year":"2007","unstructured":"Lees A (2007) Unresolved issues relating to the shaking palsy on the celebration of James Parkinson\u2019s 250th birthday. Mov Disord 22(Suppl 17):S327\u2013S334. doi: 10.1002\/mds.21684","journal-title":"Mov Disord"},{"key":"2068_CR2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/bmb\/ldn013","volume":"86","author":"CA Davie","year":"2008","unstructured":"Davie CA (2008) A review of Parkinson\u2019s disease. Br Med Bull 86:109\u2013127. doi: 10.1093\/bmb\/ldn013","journal-title":"Br Med Bull"},{"key":"2068_CR3","doi-asserted-by":"publisher","first-page":"467","DOI":"10.4061\/2011\/247467","volume":"2011","author":"T Farooqui","year":"2011","unstructured":"Farooqui T, Farooqui A (2011) Lipid-mediated oxidative stress and inflammation in the pathogenesis of Parkinson\u2019s disease. Parkinson\u2019s Dis 2011:467\u2013476. doi: 10.4061\/2011\/247467 .","journal-title":"Parkinson\u2019s Dis"},{"key":"2068_CR4","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0892-0362(02)00218-0","volume":"24","author":"KL Double","year":"2002","unstructured":"Double KL, Ben-Shachar D, Youdim MB, Zecca L, Riederer P, Gerlach M (2002) Influence of neuromelanin on oxidative pathways within the human substantia nigra. Neurotoxicol Teratol 24:621\u2013628","journal-title":"Neurotoxicol Teratol"},{"issue":"7 Suppl 2","key":"2068_CR5","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1212\/WNL.67.7_suppl_2.S8","volume":"67","author":"L Zecca","year":"2006","unstructured":"Zecca L, Zucca FA, Albertini A, Rizzio E, Fariello RG (2006) A proposed dual role of neuromelanin in the pathogenesis of Parkinson\u2019s disease. Neurology 67(7 Suppl 2):S8\u2013S11","journal-title":"Neurology"},{"key":"2068_CR6","doi-asserted-by":"publisher","first-page":"9843","DOI":"10.1073\/pnas.0403495101","volume":"101","author":"L Zecca","year":"2004","unstructured":"Zecca L, Stroppolo A, Gatti A, Tampellini D, Toscani M, Gallorini M, Giaveri G, Arosio P, Santambrogio P, Fariello RG, Karatekin E, Kleinman MH, Turro N, Hornykiewicz O, Zucca FA (2004) The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging. Proc Natl Acad Sci 101:9843\u20139848. doi: 10.1073\/pnas.0403495101","journal-title":"Proc Natl Acad Sci"},{"key":"2068_CR7","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3389\/fnmol.2014.00074","volume":"7","author":"J Smythies","year":"2014","unstructured":"Smythies J, Edelstein L (2014) The desferrioxamine-prochlorperazine coma\u2013clue to the role of dopamine-iron recycling in the synthesis of hydrogen peroxide in the brain. Front Mol Neurosci 7:74\u201376. doi: 10.3389\/fnmol.2014.00074","journal-title":"Front Mol Neurosci"},{"issue":"6","key":"2068_CR8","first-page":"414","volume":"54","author":"L Zecca","year":"2011","unstructured":"Zecca L, Tampellini D, Gerlach M, Riederer P, Fariello RG, Sulzer D. (2011) Substantia nigra neuromelanin: structure, synthesis, and molecular behaviour. Mol Pathol 54(6):414\u2013418","journal-title":"Mol Pathol"},{"issue":"27","key":"2068_CR9","doi-asserted-by":"publisher","first-page":"9977","DOI":"10.1073\/pnas.1402134111","volume":"111","author":"KM Lohr","year":"2014","unstructured":"Lohr KM, Bernstein AI, Stout KA, Dunn AR, Lazo CR, Alter SP, Want M, Li Y, Fan X, Hess EJ, Yi H, Vecchio LM, Goldstein DS, Guillot TS, Salahpour A, Miller GW (2014) Increased vesicular monoamine transporter enhances dopamine release and opposes Parkinson disease-related neurodegeneration in vivo. Proc Natl Acad Sci 111(27): 9977\u20139982. doi: 10.1073\/pnas.1402134111","journal-title":"Proc Natl Acad Sci"},{"key":"2068_CR10","doi-asserted-by":"crossref","first-page":"11869","DOI":"10.1073\/pnas.97.22.11869","volume":"97","author":"Sulzer","year":"2000","unstructured":", Sulzer, D, Bogulavsky J, Larsen KE, Behr G, Karatekin E, Kleinman MH, Turro N, Krantz D, Edwards RH, Greene LA, Zecca L (2000) Neuromelanin biosynthesis is driven by excess cytosolic catecholamines not accumulated by synaptic vesicles. Proc Natl Acad Sci 97:11869\u201311874","journal-title":"Proc Natl Acad Sci"},{"key":"2068_CR11","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF03033289","volume":"1","author":"D Sulzer","year":"2000","unstructured":"Sulzer D, Zecca L (2000) Intraneuronal dopamine-quinone synthesis: a review. Neurotox Res 1:181\u2013195","journal-title":"Neurotox Res"},{"key":"2068_CR12","doi-asserted-by":"publisher","first-page":"67","DOI":"10.2147\/TACG.S11639","volume":"4","author":"C Schulte","year":"2011","unstructured":"Schulte C, Gasser T (2011) Genetic basis of Parkinson\u2019s disease: inheritance, penetrance, and expression. Appl Clin Genet 4:67\u201380. doi: 10.2147\/TACG.S11639","journal-title":"Appl Clin Genet"},{"issue":"4","key":"2068_CR13","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1046\/j.1471-4159.2003.01917.x","volume":"86","author":"K Wakamatsu","year":"2003","unstructured":"Wakamatsu K, Fujikawa K, Zucca FA, Zecca L, Ito S (2003) The structure of neuromelanin as studied by chemical degradative methods. J Neurochem 86(4):1015\u20131023","journal-title":"J Neurochem"},{"key":"2068_CR14","doi-asserted-by":"publisher","first-page":"14785","DOI":"10.1073\/pnas.0604010103","volume":"103","author":"WD Bush","year":"2006","unstructured":"Bush WD, Garguilo J, Zucca FA, Albertini A, Zecca L, Edwards GS, Nemanich RJ, Simon JD (2006) The surface oxidation potential of human neuromelanin reveals a spherical architecture with a pheomelanin core and a eumelanin surface. Proc Natl Acad Sci 103:14785\u201314789. doi: 10.1073\/pnas.0604010103","journal-title":"Proc Natl Acad Sci"},{"key":"2068_CR15","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1111\/j.1471-4159.2004.02975.x","volume":"92","author":"H Federow","year":"2005","unstructured":"Federow H, Pickford R, Hook JM, Double KL, Halliday GM, Gerlach M, Riederer P, Garner B (2005) Dolichol is the major lipid component of human substantia nigra neuromelanin. J Neurochem 92:990\u2013995","journal-title":"J Neurochem"},{"issue":"6","key":"2068_CR16","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1600-0749.2003.00098.x","volume":"16","author":"Y Liu","year":"2003","unstructured":"Liu Y, Simon JD (2003) Isolation and biophysical studies of natural eumelanins: applications of imaging technologies and ultrafast spectroscopy. Pigment Cell Res 16(6):606\u2013618","journal-title":"Pigment Cell Res"},{"key":"2068_CR17","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1021\/ic060014r","volume":"1","author":"LK Charkoudian","year":"2006","unstructured":"Charkoudian LK, Franz KJ (2006) Fe(III)-coordination properties of neuromelanin components: 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid. Inorg Chem 1:3657\u20133664","journal-title":"Inorg Chem"},{"issue":"1","key":"2068_CR18","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1080\/07391102.2008.10507229","volume":"26","author":"G Barone","year":"2008","unstructured":"Barone G, Guerra CF, Gambino N, Silvestri A, Lauria A, Almerico AM, Bickelhaupt FM (2008) Intercalation of daunomycin into stacked DNA base pairs. DFT study of an anticancer drug. J Biomol Struct Dyn 26(1):115\u2013130. doi: 10.1080\/07391102.2008.10507229","journal-title":"J Biomol Struct Dyn"},{"key":"2068_CR19","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1007\/s00702-013-1062-5","volume":"120","author":"O Karlsson","year":"2013","unstructured":"Karlsson O, Lindquist N (2013) Melanin affinity and its possible role in neurodegeneration. J Neural Transm 120:1623\u20131630. doi: 10.1007\/s00702-013-1062-5","journal-title":"J Neural Transm"},{"key":"2068_CR20","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1096\/fj.03-0983fje","volume":"18","author":"W Zhang","year":"2004","unstructured":"Zhang W, Wang T, Qin L, Gao HM, Wilson B, Ali S, Zhang W, Hong JS, Liu B (2004) Neuroprotective effect of dextromethorphan in the MPTP Parkinson\u2019s disease model: role of NADPH oxidase. FASEB J 18:589\u2013591","journal-title":"FASEB J"},{"key":"2068_CR21","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1126\/science.3080808","volume":"231","author":"R D\u2019Amato","year":"1986","unstructured":"D\u2019Amato R, Lipman Z, Snyder S (1986) Selectivity of the parkinsonian neurotoxin MPTP: toxic metabolite MPP+ binds to neuromelanin. Science 231:987\u2013989","journal-title":"Science"},{"key":"2068_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1471-4159.1987.tb03384.x","volume":"49","author":"T Singer","year":"2006","unstructured":"Singer T, Castagnoli Jr. N, Ramsay R, Trevor A (2006) Biochemical events in the development of Parkinsonism induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine. J Neurochem 49:1\u20138. doi: 10.1111\/j.1471-4159.1987.tb03384.x","journal-title":"J Neurochem"},{"key":"2068_CR23","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1073\/pnas.82.7.2173","volume":"82","author":"JA Javitch","year":"1985","unstructured":"Javitch JA, D\u2019amato RJ, Strittmatter SM, Snyder SH (1985) Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci 82:2173\u20132177.","journal-title":"Proc Natl Acad Sci"},{"key":"2068_CR24","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1111\/j.1471-4159.2009.06011.x","volume":"109","author":"LZ Huang","year":"2009","unstructured":"Huang LZ, Parameswaran N, Bordia T, McIntosh JM, Quik M (2009) Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys. J Neurochem 109:826\u2013837. doi: 10.1111\/j.1471-4159.2009.06011.x","journal-title":"J Neurochem"},{"key":"2068_CR25","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1111\/j.1471-4159.2008.05697.x","volume":"107","author":"X Chen","year":"2008","unstructured":"Chen X, Lan X, Roche I, Liu R, Geiger J (2008) Caffeine protects against MPTP-induced blood\u2013brain barrier dysfunction in mouse striatum. J Neurochem 107:1147\u20131157. doi: 10.1111\/j.1471-4159.2008.05697.x","journal-title":"J Neurochem"},{"key":"2068_CR26","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1046\/j.1471-4159.2000.0741758.x","volume":"74","author":"L Zecca","year":"2000","unstructured":"Zecca L, Costi P, Mecacci C, Ito S, Terreni M, Sonnino S (2000) Interaction of human substantia nigra neuromelanin with lipids and peptides. J Neurochem 74:1758\u20131765","journal-title":"J Neurochem"},{"key":"2068_CR27","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1471-4159.2005.03342.x","volume":"95","author":"ST Kim","year":"2005","unstructured":"Kim ST, Choi JH, Chang JW, Kim SW, Hwang O (2005) Immobilization stress causes increases in tetrahydrobiopterin, dopamine, and neuromelanin and oxidative damage in the nigrostriatal system. J Neurochem 95:89\u201398. doi: 10.1111\/j.1471-4159.2005.03342.x","journal-title":"J Neurochem"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-016-2068-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-016-2068-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-016-2068-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T22:48:12Z","timestamp":1568414892000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-016-2068-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,23]]},"references-count":27,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["2068"],"URL":"https:\/\/doi.org\/10.1007\/s11064-016-2068-9","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,23]]}}}