{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:24:19Z","timestamp":1790627059083,"version":"4.1.0"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T00:00:00Z","timestamp":1484611200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1007\/s11064-017-2175-2","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T06:13:48Z","timestamp":1484633628000},"page":"1317-1324","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Cdc42 Promotes Schwann Cell Proliferation and Migration Through Wnt\/\u03b2-Catenin and p38 MAPK Signaling Pathway After Sciatic Nerve Injury"],"prefix":"10.1007","volume":"42","author":[{"given":"Bin","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ying","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu-tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai-ping","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-yang","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,17]]},"reference":[{"key":"2175_CR1","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1126\/science.2011742","volume":"251","author":"J Sato","year":"1991","unstructured":"Sato J, Perl ER (1991) Adrenergic excitation of cutaneous pain receptors induced by peripheral nerve injury. Science 251:1608\u20131610","journal-title":"Science"},{"key":"2175_CR2","doi-asserted-by":"publisher","DOI":"10.1080\/21541248.2016.1194952","author":"AJ Farrugia","year":"2016","unstructured":"Farrugia AJ, Calvo F (2016) Cdc42 regulates Cdc42EP3 function in cancer-associated fibroblasts. Small GTPases, doi: \n10.1080\/21541248.2016.1194952","journal-title":"Small GTPases"},{"key":"2175_CR3","doi-asserted-by":"publisher","first-page":"730","DOI":"10.1002\/glia.22957","volume":"64","author":"SY Jang","year":"2015","unstructured":"Jang SY, Shin YK, Park SY, Park JY, Lee HJ, Yoo YH, Kim JK, Park HT (2015) Autophagic myelin destruction by schwann cells during wallerian degeneration and segmental demyelination. Glia 64:730\u2013742","journal-title":"Glia"},{"key":"2175_CR4","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1016\/j.cellsig.2008.05.002","volume":"20","author":"S Sinha","year":"2008","unstructured":"Sinha S, Yang W (2008) Cellular signaling for activation of Rho GTPase Cdc42. Cell Signal 20:1927\u20131934","journal-title":"Cell Signal"},{"key":"2175_CR5","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1046\/j.1471-4159.2001.00336.x","volume":"77","author":"T Terashima","year":"2001","unstructured":"Terashima T, Yasuda H, Terada M, Kogawa S, Maeda K, Haneda M, Kashiwagi A, Kikkawa R (2001) Expression of Rho-family GTPases (Rac, cdc42, RhoA) and their association with p-21 activated kinase in adult rat peripheral nerve. J Neurochem 77:986\u2013993","journal-title":"J Neurochem"},{"key":"2175_CR6","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/cne.20471","volume":"484","author":"MK Erschbamer","year":"2005","unstructured":"Erschbamer MK, Hofstetter CP, Olson L (2005) RhoA, RhoB, RhoC, Rac1, Cdc42, and Tc10 mRNA levels in spinal cord, sensory ganglia, and corticospinal tract neurons and long-lasting specific changes following spinal cord injury. J Comp Neurol 484:224\u2013233","journal-title":"J Comp Neurol"},{"key":"2175_CR7","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1038\/nprot.2012.118","volume":"7","author":"R Kaewkhaw","year":"2012","unstructured":"Kaewkhaw R, Scutt AM, Haycock JW (2012) Integrated culture and purification of rat Schwann cells from freshly isolated adult tissue. Nat Protoc 7:1996\u20132004","journal-title":"Nat Protoc"},{"key":"2175_CR8","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1007\/s10529-010-0230-z","volume":"32","author":"A Niapour","year":"2010","unstructured":"Niapour A, Karamali F, Karbalaie K, Kiani A, Mardani M, Nasr-Esfahani MH, Baharvand H (2010) Novel method to obtain highly enriched cultures of adult rat Schwann cells. Biotechnol Lett 32:781\u2013786","journal-title":"Biotechnol Lett"},{"key":"2175_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/bbrc.1999.1122","volume":"262","author":"S Kuroda","year":"1999","unstructured":"Kuroda S, Fukata M, Nakagawa M, Kaibuchi K (1999) Cdc42, Rac1, and their effector IQGAP1 as molecular switches for cadherin-mediated cell-cell adhesion. Biochem Biophys Res Commun 262:1\u20136","journal-title":"Biochem Biophys Res Commun"},{"key":"2175_CR10","doi-asserted-by":"publisher","first-page":"3079","DOI":"10.1172\/JCI37694","volume":"119","author":"M Maillet","year":"2009","unstructured":"Maillet M, Lynch JM, Sanna B, York AJ, Zheng Y, Molkentin JD (2009) Cdc42 is an antihypertrophic molecular switch in the mouse heart. J Clin Invest 119:3079\u20133088","journal-title":"J Clin Invest"},{"key":"2175_CR11","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1083\/jcb.200701083","volume":"178","author":"K Schlessinger","year":"2007","unstructured":"Schlessinger K, McManus EJ, Hall A (2007) Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity. J Cell Biol 178:355\u2013361","journal-title":"J Cell Biol"},{"key":"2175_CR12","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1006\/dbio.2002.0602","volume":"244","author":"SC Choi","year":"2002","unstructured":"Choi SC, Han JK (2002) Xenopus Cdc42 regulates convergent extension movements during gastrulation through Wnt\/Ca2+ signaling pathway. Dev Biol 244:342\u2013357","journal-title":"Dev Biol"},{"key":"2175_CR13","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/35004513","volume":"404","author":"AS Kim","year":"2000","unstructured":"Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK (2000) Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature 404:151\u2013158","journal-title":"Nature"},{"key":"2175_CR14","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1016\/j.ceca.2005.06.022","volume":"38","author":"AD Kohn","year":"2005","unstructured":"Kohn AD, Moon RT (2005) Wnt and calcium signaling: beta-catenin-independent pathways. Cell Calcium 38:439\u2013446","journal-title":"Cell Calcium"},{"key":"2175_CR15","doi-asserted-by":"publisher","first-page":"5198","DOI":"10.1073\/pnas.0501160102","volume":"102","author":"J Yamauchi","year":"2005","unstructured":"Yamauchi J, Chan JR, Miyamoto Y, Tsujimoto G, Shooter EM (2005) The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migration. Proc Natl Acad Sci USA 102:5198\u20135203","journal-title":"Proc Natl Acad Sci USA"},{"key":"2175_CR16","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.taap.2016.05.003","volume":"303","author":"J Mao","year":"2016","unstructured":"Mao J, Yang J, Zhang Y, Li T, Wang C, Xu L, Hu Q, Wang X, Jiang S, Nie X, Chen G (2016) Arsenic trioxide mediates HAPI microglia inflammatory response and subsequent neuron apoptosis through p38\/JNK MAPK\/STAT3 pathway. Toxicol Appl Pharmacol 303:79\u201389","journal-title":"Toxicol Appl Pharmacol"},{"key":"2175_CR17","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/12963","volume":"1","author":"DC Edwards","year":"1999","unstructured":"Edwards DC, Sanders LC, Bokoch GM, Gill GN (1999) Activation of LIM-kinase by Pak1 couples Rac\/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol 1:253\u2013259","journal-title":"Nat Cell Biol"},{"key":"2175_CR18","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1242\/jcs.01115","volume":"117","author":"S Etienne-Manneville","year":"2004","unstructured":"Etienne-Manneville S (2004) Cdc42\u2013the centre of polarity. J Cell Sci 117:1291\u20131300","journal-title":"J Cell Sci"},{"key":"2175_CR19","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1083\/jcb.111.1.143","volume":"111","author":"DI Johnson","year":"1990","unstructured":"Johnson DI, Pringle JR (1990) Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J Cell Biol 111:143\u2013152","journal-title":"J Cell Biol"},{"key":"2175_CR20","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.devcel.2008.01.001","volume":"14","author":"Y Shen","year":"2008","unstructured":"Shen Y, Li N, Wu S, Zhou Y, Shan Y, Zhang Q, Ding C, Yuan Q, Zhao F, Zeng R, Zhu X (2008) Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells. Dev Cell 14:342\u2013353","journal-title":"Dev Cell"},{"key":"2175_CR21","doi-asserted-by":"publisher","first-page":"3875","DOI":"10.1074\/jbc.M403788200","volume":"280","author":"Y Qian","year":"2005","unstructured":"Qian Y, Liu KJ, Chen Y, Flynn DC, Castranova V, Shi X (2005) Cdc42 regulates arsenic-induced NADPH oxidase activation and cell migration through actin filament reorganization. J Biol Chem 280:3875\u20133884","journal-title":"J Biol Chem"},{"key":"2175_CR22","doi-asserted-by":"publisher","first-page":"e38075","DOI":"10.1371\/journal.pone.0038075","volume":"7","author":"X Wang","year":"2012","unstructured":"Wang X, Ke Z, Chen G, Xu M, Bower KA, Frank JA, Zhang Z, Shi X, Luo J (2012) Cdc42-dependent activation of NADPH oxidase is involved in ethanol-induced neuronal oxidative stress. PLoS ONE 7:e38075","journal-title":"PLoS ONE"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-017-2175-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-017-2175-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-017-2175-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T04:36:03Z","timestamp":1492662963000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-017-2175-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,17]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["2175"],"URL":"https:\/\/doi.org\/10.1007\/s11064-017-2175-2","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,17]]}}}