{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:14:14Z","timestamp":1787501654941,"version":"build-2736575974"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:00:00Z","timestamp":1528070400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1007\/s11064-018-2539-2","type":"journal-article","created":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T00:52:23Z","timestamp":1528073543000},"page":"1308-1316","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Lead Neurotoxicity on Human Neuroblastoma Cell Line SH-SY5Y is Mediated via Transcription Factor EGR1\/Zif268 Induced Disrupted in Scherophernia-1 Activation"],"prefix":"10.1007","volume":"43","author":[{"given":"Yuanyuan","family":"You","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songbin","family":"Ben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijian","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,4]]},"reference":[{"key":"2539_CR1","doi-asserted-by":"publisher","first-page":"579588","DOI":"10.1039\/C5MT00300H","volume":"8","author":"JM Ordemann","year":"2016","unstructured":"Ordemann JM, Austin RN (2016) Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health. Metallomics 8:579\u2013588","journal-title":"Metallomics"},{"key":"2539_CR2","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/S0896-6273(03)00645-7","volume":"40","author":"G Krapivinsky","year":"2003","unstructured":"Krapivinsky G, Krapivinsky L, Manasian Y et al (2003) The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF1. Neuron 40:775\u2013784","journal-title":"Neuron"},{"key":"2539_CR3","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.brainresrev.2005.02.004","volume":"49","author":"CD Toscano","year":"2005","unstructured":"Toscano CD, Guilarte TR (2005) Lead neurotoxicity: from exposure to molecular effects. Brain Res Rev 49:529","journal-title":"Brain Res Rev"},{"key":"2539_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/brain\/awg014","volume":"126","author":"TI Lidsky","year":"2003","unstructured":"Lidsky TI, Schneider JS (2003) Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 126:5\u201319","journal-title":"Brain"},{"key":"2539_CR5","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1177\/088307389200700404","volume":"7","author":"RG Feldman","year":"1992","unstructured":"Feldman RG, White RF (1992) Lead neurotoxicity and disorders of learning. J Child Neurol 7:354\u2013359","journal-title":"J Child Neurol"},{"key":"2539_CR6","first-page":"2","volume":"11","author":"L Patrick","year":"2006","unstructured":"Patrick L (2006) Lead toxicity, a review of the literature. Part 1: exposure, evaluation, and treatment. Altern Med Rev A J Clin Ther 11:2\u201322","journal-title":"Altern Med Rev A J Clin Ther"},{"key":"2539_CR7","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1542\/peds.93.2.343a","volume":"93","author":"GA Gellert","year":"1994","unstructured":"Gellert GA, Wagner GA, Maxwell RM, Moore D, Foster L (1994) Lead poisoning: from screening to primary prevention. Pediatrics 93:343","journal-title":"Pediatrics"},{"key":"2539_CR8","doi-asserted-by":"publisher","first-page":"563","DOI":"10.2174\/156720512800617991","volume":"9","author":"KM Bakulski","year":"2012","unstructured":"Bakulski KM, Rozek LS, Dolinoy DC, Paulson HL, Hu H (2012) Alzheimer\u2019s disease and environmental exposure to lead: the epidemiologic evidence and potential role of epigenetics. Curr Alzheimer Res 9:563\u2013573","journal-title":"Curr Alzheimer Res"},{"key":"2539_CR9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.neuro.2014.03.008","volume":"43","author":"J Lee","year":"2014","unstructured":"Lee J, Freeman JL (2014) Zebrafish as a model for investigating developmental lead (Pb) neurotoxicity as a risk factor in adult neurodegenerative disease: a mini-review. Neurotoxicology 43:57\u201364","journal-title":"Neurotoxicology"},{"key":"2539_CR10","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1289\/ehp.1002339","volume":"118","author":"MG Weisskopf","year":"2010","unstructured":"Weisskopf MG, Weuve J, Nie HL et al (2010) Association of cumulative lead exposure with Parkinson\u2019s disease. Environ Health Perspect 118:1609","journal-title":"Environ Health Perspect"},{"key":"2539_CR11","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1289\/ehp.9102","volume":"114","author":"S Coon","year":"2006","unstructured":"Coon S, Stark A, Peterson E et al (2006) Whole-body lifetime occupational lead exposure and risk of Parkinson\u2019s disease. Environ Health Perspect 114:1872\u20131876","journal-title":"Environ Health Perspect"},{"key":"2539_CR12","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1289\/ehp.6777","volume":"112","author":"MGA Opler","year":"2004","unstructured":"Opler MGA, Brown AS, Graziano J et al (2004) Prenatal lead exposure, delta-aminolevulinic acid, and schizophrenia. Environ Health Perspect 112:548\u2013552","journal-title":"Environ Health Perspect"},{"key":"2539_CR13","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.neuro.2011.11.008","volume":"33","author":"TR Guilarte","year":"2012","unstructured":"Guilarte TR, Opler M, Pletnikov M (2012) Is lead exposure in early life an environmental risk factor for Schizophrenia? Neurobiological connections and testable hypotheses. Neurotoxicology 33:560\u2013574","journal-title":"Neurotoxicology"},{"key":"2539_CR14","first-page":"41","volume":"190","author":"Y Ahn","year":"2015","unstructured":"Ahn Y, Yoon JH (2015) P202 The association between blood lead level and clinical mental disorders in fifty thousand lead-exposed male workers. J Affect Disord 190:41","journal-title":"J Affect Disord"},{"key":"2539_CR15","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/132671","author":"S Sadiq","year":"2012","unstructured":"Sadiq S, Ghazala Z, Chowdhury A, B\u00fcsselberg D (2012) Metal toxicity at the synapse: presynaptic, postsynaptic, and long-term effects. J Toxicol. https:\/\/doi.org\/10.1155\/2012\/132671","journal-title":"J Toxicol"},{"key":"2539_CR16","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1196\/annals.1300.020","volume":"1003","author":"JT Coyle","year":"2003","unstructured":"Coyle JT, Tsai G, Goff D (2003) Converging evidence of NMDA receptor hypofunction in the pathophysiology of Schizophrenia. Ann N Y Acad Sci 1003:318\u2013327","journal-title":"Ann N Y Acad Sci"},{"key":"2539_CR17","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/0166-2236(92)90034-6","volume":"15","author":"HA Robertson","year":"1992","unstructured":"Robertson HA (1992) Dopamine receptor interactions: some implications for the treatment of Parkinson\u2019s disease. Trends Neurosci 15:201\u2013206","journal-title":"Trends Neurosci"},{"key":"2539_CR18","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1016\/j.cell.2009.03.005","volume":"136","author":"GL Ming","year":"2009","unstructured":"Ming GL, Song H (2009) DISC1 partners with GSK3\u03b2 in neurogenesis. Cell 136:990\u2013992","journal-title":"Cell"},{"key":"2539_CR19","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1093\/hmg\/9.9.1415","volume":"9","author":"JK Millar","year":"2000","unstructured":"Millar JK, Wilson-Annan JC, Anderson S et al (2000) Disruption of two novel genes by a translocation co-segregating with schizophrenia. Hum Mol Genet 9:1415","journal-title":"Hum Mol Genet"},{"key":"2539_CR20","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1086\/321969","volume":"69","author":"DH Blackwood","year":"2001","unstructured":"Blackwood DH, Fordyce A, Walker MT, St Clair DM, Porteous DJ, Muir WJ (2001) Schizophrenia and affective disorders\u2013cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet 69:428","journal-title":"Am J Hum Genet"},{"key":"2539_CR21","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1001\/archpsyc.62.10.1081","volume":"62","author":"ML Hamshere","year":"2005","unstructured":"Hamshere ML, Bennett P, Williams N et al (2005) Genomewide linkage scan in schizoaffective disorder: significant evidence for linkage at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19p13. Arch Gen Psychiatry 62:1081\u20131088","journal-title":"Arch Gen Psychiatry"},{"key":"2539_CR22","doi-asserted-by":"publisher","first-page":"3024","DOI":"10.1093\/hmg\/ddl244","volume":"15","author":"R Hashimoto","year":"2006","unstructured":"Hashimoto R, Numakawa T, Ohnishi T et al (2006) Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling. Hum Mol Genet 15:3024","journal-title":"Hum Mol Genet"},{"key":"2539_CR23","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1016\/j.neuron.2009.08.008","volume":"63","author":"YK Ju","year":"2009","unstructured":"Ju YK, Duan X, Liu CY et al (2009) DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron 63:761","journal-title":"Neuron"},{"key":"2539_CR24","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/jcp.10178","volume":"193","author":"G Thiel","year":"2002","unstructured":"Thiel G, Cibelli G (2002) Regulation of life and death by the zinc finger transcription factor Egr-1. J Cell Physiol 193:287","journal-title":"J Cell Physiol"},{"key":"2539_CR25","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/S0006-8993(97)00430-7","volume":"765","author":"TS Smith","year":"1997","unstructured":"Smith TS, Trimmer PA, Khan SM, Tinklepaugh DL, Bennett JP Jr (1997) Mitochondrial toxins in models of neurodegenerative diseases. II: Elevated zif268 transcription and independent temporal regulation of striatal D1 and D2 receptor mRNAs and D1 and D2 receptor-binding sites in C57BL\/6 mice during MPTP treatment. Brain Res 765:189","journal-title":"Brain Res"},{"key":"2539_CR26","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1111\/j.1471-4159.2008.05233.x","volume":"105","author":"K Tureyen","year":"2008","unstructured":"Tureyen K, Brooks N, Bowen K, Svaren J, Vemuganti R (2008) Transcription factor early growth response-1 induction mediates inflammatory gene expression and brain damage following transient focal ischemia. J Neurochem 105:1313\u20131324","journal-title":"J Neurochem"},{"key":"2539_CR27","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/S0736-5748(00)00048-4","volume":"18","author":"GR Reddy","year":"2000","unstructured":"Reddy GR, Zawia NH (2000) Lead exposure alters Egr-1 DNA-binding in the neonatal rat brain. Int J Dev Neurosci 18:791\u2013795","journal-title":"Int J Dev Neurosci"},{"key":"2539_CR28","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/0736-5748(95)00032-C","volume":"13","author":"NH Zawia","year":"1995","unstructured":"Zawia NH, Harry GJ (1995) Exposure to lead-acetate modulates the developmental expression of myelin genes in the rat frontal lobe. Int J Dev Neurosci 13:639","journal-title":"Int J Dev Neurosci"},{"key":"2539_CR29","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1006\/taap.1996.0095","volume":"138","author":"NH Zawia","year":"1996","unstructured":"Zawia NH, Harry GJ (1996) Developmental exposure to lead interferes with glial and neuronal differential gene expression in the rat cerebellum. Toxicol Appl Pharmacol 138:43\u201347","journal-title":"Toxicol Appl Pharmacol"},{"key":"2539_CR30","first-page":"407","volume":"17","author":"TJ Schmitt","year":"1996","unstructured":"Schmitt TJ, Zawia N, Harry GJ (1996) GAP-43 mRNA expression in the developing rat brain: alterations following lead-acetate exposure. Neurotoxicology 17:407\u2013414","journal-title":"Neurotoxicology"},{"key":"2539_CR31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0736-5748(02)00137-5","volume":"21","author":"MR Basha","year":"2003","unstructured":"Basha MR, Wei W, Brydie M, Razmiafshari M, Zawia NH (2003) Lead-induced developmental perturbations in hippocampal Sp1 DNA-binding are prevented by zinc supplementation: in vivo evidence for Pb and Zn competition. Int J Dev Neurosci 21:1\u201312","journal-title":"Int J Dev Neurosci"},{"key":"2539_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/taap.2001.9132","volume":"172","author":"M Razmiafshari","year":"2001","unstructured":"Razmiafshari M, Kao J, D\u2019Avignon A, Zawia NH (2001) NMR identification of heavy metal-binding sites in a synthetic zinc finger peptide: toxicological implications for the interactions of xenobiotic metals with zinc finger proteins. Toxicol Appl Pharmacol 172:1","journal-title":"Toxicol Appl Pharmacol"},{"key":"2539_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/taap.2000.8950","volume":"166","author":"M Razmiafshari","year":"2000","unstructured":"Razmiafshari M, Zawia NH (2000) Utilization of a synthetic peptide as a tool to study the interaction of heavy metals with the zinc finger domain of proteins critical for gene expression in the developing brain. Toxicol Appl Pharmacol 166:1\u201312","journal-title":"Toxicol Appl Pharmacol"},{"key":"2539_CR34","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.jinorgbio.2004.01.014","volume":"98","author":"M Huang","year":"2004","unstructured":"Huang M, Krepkiy D, Hu W, Petering DH: Zn- (2004) Cd-, and Pb-transcription factor IIIA: properties, DNA binding, and comparison with TFIIIA-finger 3 metal complexes. J Inorg Biochem 98:775","journal-title":"J Inorg Biochem"},{"key":"2539_CR35","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1023\/A:1020702213099","volume":"16","author":"MD Garrick","year":"2003","unstructured":"Garrick MD, Dolan KG, Horbinski C et al (2003) DMT1: a mammalian transporter for multiple metals. Biometals 16:41\u201354","journal-title":"Biometals"},{"key":"2539_CR36","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.pneurobio.2004.05.007","volume":"74","author":"E Knapska","year":"2004","unstructured":"Knapska E, Kaczmarek L (2004) A gene for neuronal plasticity in the mammalian brain: Zif268\/Egr-1\/NGFI-A\/Krox-24\/TIS8\/ZENK? Prog Neurobiol 74:183\u2013211","journal-title":"Prog Neurobiol"},{"key":"2539_CR37","doi-asserted-by":"publisher","first-page":"27679","DOI":"10.1074\/jbc.270.46.27679","volume":"270","author":"LM Khachigian","year":"1995","unstructured":"Khachigian LM, Williams AJ, Collins T (1995) Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells. J Biol Chem 270:27679\u201327686","journal-title":"J Biol Chem"},{"key":"2539_CR38","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1126\/science.271.5254.1427","volume":"271","author":"LM Khachigian","year":"1996","unstructured":"Khachigian LM, Lindner V, Williams AJ, Collins T (1996) Egr-1-induced endothelial gene expression: a common theme in vascular injury. Science 271:1427\u20131431","journal-title":"Science"},{"key":"2539_CR39","doi-asserted-by":"publisher","first-page":"38524","DOI":"10.1074\/jbc.M005220200","volume":"275","author":"J Svaren","year":"2000","unstructured":"Svaren J, Ehrig T, Abdulkadir SA, Ehrengruber MU, Watson MA, Milbrandt J (2000) EGR1 target genes in prostate carcinoma cells identified by microarray analysis. J Biol Chem 275:38524","journal-title":"J Biol Chem"},{"key":"2539_CR40","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1074\/jbc.274.3.1801","volume":"274","author":"KJ Townsend","year":"1999","unstructured":"Townsend KJ, Zhou P, Qian L et al (1999) Regulation of MCL1 through a serum response factor\/Elk-1-mediated mechanism links expression of a viability-promoting member of the BCL2 family to the induction of hematopoietic cell differentiation. J Biol Chem 274:1801\u20131813","journal-title":"J Biol Chem"},{"key":"2539_CR41","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.bbagen.2009.11.009","volume":"1800","author":"KF Tang","year":"2010","unstructured":"Tang KF, Song GB, Shi YS, Yuan L, Li YH (2010) Dicer knockdown induces fibronectin-1 expression in HEK293T cells via induction of Egr1. Biochim et Biophys Acta 1800:380","journal-title":"Biochim et Biophys Acta"},{"key":"2539_CR42","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/sj.cgt.7700896","volume":"13","author":"V Baron","year":"2006","unstructured":"Baron V, Adamson ED, Calogero A, Ragona G, Mercola D (2006) The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin. Cancer Gene Ther 13:115\u2013124","journal-title":"Cancer Gene Ther"},{"key":"2539_CR43","doi-asserted-by":"publisher","first-page":"R166","DOI":"10.1186\/gb-2008-9-11-r166","volume":"9","author":"S Arora","year":"2008","unstructured":"Arora S, Wang Y, Jia Z et al (2008) Egr1 regulates the coordinated expression of numerous EGF receptor target genes as identified by ChIP-on-chip. Genome Biol 9:R166","journal-title":"Genome Biol"},{"key":"2539_CR44","doi-asserted-by":"publisher","first-page":"9043","DOI":"10.1523\/JNEUROSCI.5410-10.2011","volume":"31","author":"NJ Bradshaw","year":"2011","unstructured":"Bradshaw NJ, Soares DC, Carlyle BC et al (2011) PKA phosphorylation of NDE1 is DISC1\/PDE4 dependent and modulates its interaction with LIS1 and NDEL1. J Neurosci 31:9043","journal-title":"J Neurosci"},{"key":"2539_CR45","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1093\/hmg\/9.7.1049","volume":"9","author":"J Ekelund","year":"2000","unstructured":"Ekelund J, Lichtermann D, Hovatta I et al (2000) Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22. Hum Mol Genet 9:1049\u20131057","journal-title":"Hum Mol Genet"},{"key":"2539_CR46","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7694385","author":"BK Unda","year":"2016","unstructured":"Unda BK, Kwan V, Singh KK (2016) Neuregulin-1 regulates cortical inhibitory neuron dendrite and synapse growth through DISC1. Neural Plast. https:\/\/doi.org\/10.1155\/2016\/7694385","journal-title":"Neural Plast"},{"key":"2539_CR47","doi-asserted-by":"publisher","first-page":"e1081715","DOI":"10.1080\/23262133.2015.1081715","volume":"2","author":"E Kang","year":"2015","unstructured":"Kang E, Kim JY, Liu CY et al. (2015) Rheb1 mediates DISC1-dependent regulation of new neuron development in the adult hippocampus. Neurogenesis 2:e1081715","journal-title":"Neurogenesis"},{"key":"2539_CR48","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.mcn.2013.01.006","volume":"54","author":"AM Lepagnol-Bestel","year":"2013","unstructured":"Lepagnol-Bestel AM, Kvajo M, Karayiorgou M, Simonneau M, Gogos JA (2013) A Disc1 mutation differentially affects neurites and spines in hippocampal and cortical neurons. Mol Cell Neurosci 54:84\u201392","journal-title":"Mol Cell Neurosci"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-018-2539-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-018-2539-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-018-2539-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T19:37:49Z","timestamp":1661369869000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-018-2539-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,4]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["2539"],"URL":"https:\/\/doi.org\/10.1007\/s11064-018-2539-2","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,4]]},"assertion":[{"value":"9 November 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Authors declared no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}