{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T05:49:34Z","timestamp":1776491374040,"version":"3.51.2"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T00:00:00Z","timestamp":1531353600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2015020549"],"award-info":[{"award-number":["2015020549"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dalian Municipal Health and Family Planning Project","award":["1711014"],"award-info":[{"award-number":["1711014"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300985"],"award-info":[{"award-number":["81300985"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s11064-018-2594-8","type":"journal-article","created":{"date-parts":[[2018,7,12]],"date-time":"2018-07-12T04:53:20Z","timestamp":1531371200000},"page":"1714-1722","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["NCAM Mimetic Peptides: Potential Therapeutic Target for Neurological Disorders"],"prefix":"10.1007","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4486-1051","authenticated-orcid":false,"given":"Chengyan","family":"Chu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,7,12]]},"reference":[{"key":"2594_CR1","doi-asserted-by":"publisher","first-page":"2291","DOI":"10.3390\/ijms11062291","volume":"11","author":"S Li","year":"2010","unstructured":"Li S, Bock E, Berezin V (2010) Neuritogenic and neuroprotective properties of peptide agonists of the fibroblast growth factor receptor. Int J Mol Sci 11:2291\u20132305","journal-title":"Int J Mol Sci"},{"key":"2594_CR2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/978-1-4757-5876-4_18","volume":"265","author":"O Nybroe","year":"1990","unstructured":"Nybroe O, Bock E (1990) Structure and function of the neural cell adhesion molecules NCAM and L1. Adv Exp Med Biol 265:185\u2013196","journal-title":"Adv Exp Med Biol"},{"key":"2594_CR3","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1101\/SQB.1990.055.01.032","volume":"55","author":"GM Edelman","year":"1990","unstructured":"Edelman GM, Cunningham BA (1990) Place-dependent cell adhesion, process retraction, and spatial signaling in neural morphogenesis. Cold Spring Harb Symp Quant Biol 55:303\u2013318","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"2594_CR4","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1146\/annurev.cb.02.110186.000501","volume":"2","author":"GM Edelman","year":"1986","unstructured":"Edelman GM (1986) Cell adhesion molecules in the regulation of animal form and tissue pattern. Annu Rev Cell Biol 2:81\u2013116","journal-title":"Annu Rev Cell Biol"},{"key":"2594_CR5","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1016\/S0531-5565(98)00040-0","volume":"33","author":"LC Ronn","year":"1998","unstructured":"Ronn LC, Hartz BP, Bock E (1998) The neural cell adhesion molecule (NCAM) in development and plasticity of the nervous system. Exp Gerontol 33:853\u2013864","journal-title":"Exp Gerontol"},{"key":"2594_CR6","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1038\/nn1827","volume":"10","author":"PF Maness","year":"2007","unstructured":"Maness PF, Schachner M (2007) Neural recognition molecules of the immunoglobulin superfamily: signaling transducers of axon guidance and neuronal migration. Nat Neurosci 10:19\u201326","journal-title":"Nat Neurosci"},{"key":"2594_CR7","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/cne.902880108","volume":"288","author":"E Persohn","year":"1989","unstructured":"Persohn E, Pollerberg GE, Schachner M (1989) Immunoelectron-microscopic localization of the 180 kD component of the neural cell adhesion molecule N-CAM in postsynaptic membranes. J Comp Neurol 288:92\u2013100","journal-title":"J Comp Neurol"},{"key":"2594_CR8","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1101\/SQB.1983.048.01.056","volume":"48","author":"GM Edelman","year":"1983","unstructured":"Edelman GM, Hoffman S, Chuong CM, Thiery JP, Brackenbury R, Gallin WJ, Grumet M, Greenberg ME, Hemperly JJ, Cohen C et al (1983) Structure and modulation of neural cell adhesion molecules in early and late embryogenesis. Cold Spring Harb Symp Quant Biol 48:515\u2013526","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"2594_CR9","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1126\/science.3576199","volume":"236","author":"BA Cunningham","year":"1987","unstructured":"Cunningham BA, Hemperly JJ, Murray BA, Prediger EA, Brackenbury R, Edelman GM (1987) Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing. Science 236:799\u2013806","journal-title":"Science"},{"key":"2594_CR10","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1111\/j.1471-4159.2004.02779.x","volume":"91","author":"JL Neiiendam","year":"2004","unstructured":"Neiiendam JL, K\u00f8hler LB, Christensen C, Li S, Pedersen MV, Ditlevsen DK, Kornum MK, Kiselyov VV, Berezin V, Bock E (2004) An NCAM-derived FGF-receptor agonist, the FGL-peptide, induces neurite outgrowth and neuronal survival in primary rat neurons. J Neurochem 91:920\u2013935","journal-title":"J Neurochem"},{"key":"2594_CR11","doi-asserted-by":"publisher","first-page":"805497","DOI":"10.1155\/2013\/805497","volume":"2013","author":"SR Wainwright","year":"2013","unstructured":"Wainwright SR, Galea LA (2013) The neural plasticity theory of depression: assessing the roles of adult neurogenesis and PSA-NCAM within the hippocampus. Neural Plast 2013:805497","journal-title":"Neural Plast"},{"key":"2594_CR12","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1523\/JNEUROSCI.1238-12.2013","volume":"33","author":"S Li","year":"2013","unstructured":"Li S, Leshchyns\u2019ka I, Chernyshova Y, Schachner M, Sytnyk V (2013) The neural cell adhesion molecule (NCAM) associates with and signals through p21-Activated Kinase 1 (Pak1). J Neurosci 33:790\u2013790+","journal-title":"J Neurosci"},{"key":"2594_CR13","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1007\/s11064-013-1007-2","volume":"38","author":"G Dall\u00e9rac","year":"2013","unstructured":"Dall\u00e9rac G, Rampon C, Doy\u00e8re V (2013) NCAM function in the adult brain: lessons from mimetic peptides and therapeutic potential. Neurochem Res 38:1163\u20131173","journal-title":"Neurochem Res"},{"key":"2594_CR14","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1007\/s11064-004-6875-z","volume":"29","author":"PS Walmod","year":"2004","unstructured":"Walmod PS, Kolkova K, Berezin V, Bock E (2004) Zippers make signals: NCAM-mediated molecular interactions and signal transduction. Neurochem Res 29:2015\u20132035","journal-title":"Neurochem Res"},{"key":"2594_CR15","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1016\/j.str.2003.09.006","volume":"11","author":"V Soroka","year":"2003","unstructured":"Soroka V, Kolkova K, Kastrup JS, Diederichs K, Breed J, Kiselyov VV, Poulsen FM, Larsen IK, Welte W, Berezin V, Bock E, Kasper C (2003) Structure and interactions of NCAM Ig1-2-3 suggest a novel zipper mechanism for homophilic adhesion. Structure 11:1291\u20131301","journal-title":"Structure"},{"key":"2594_CR16","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1111\/j.1471-4159.2008.05544.x","volume":"106","author":"SMM Hansen","year":"2008","unstructured":"Hansen SMM, K\u00f8hler LB, Li S, Kiselyov V, Christensen C, Owczarek S, Bock E, Berezin V (2008) NCAM-derived peptides function as agonists for the fibroblast growth factor receptor. J Neurochem 106:2030\u20132041","journal-title":"J Neurochem"},{"key":"2594_CR17","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/jnr.21888","volume":"87","author":"A Burgess","year":"2009","unstructured":"Burgess A, Saini S, Weng YQ, Aubert I (2009) Stimulation of choline acetyltransferase by C3d, a neural cell adhesion molecule ligand. J Neurosci Res 87:609\u2013616","journal-title":"J Neurosci Res"},{"key":"2594_CR18","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.neulet.2009.01.080","volume":"452","author":"VV Kiselyov","year":"2009","unstructured":"Kiselyov VV, Li S, Berezin V, Bock E (2009) Insight into the structural mechanism of the bi-modal action of an NCAM mimetic, the C3 peptide. Neurosci Lett 452:224\u2013227","journal-title":"Neurosci Lett"},{"key":"2594_CR19","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.pnpbp.2017.02.016","volume":"76","author":"S Hidese","year":"2017","unstructured":"Hidese S, Hattori K, Sasayama D, Miyakawa T, Matsumura R, Yokota Y, Ishida I, Matsuo J, Noda T, Yoshida S, Teraishi T, Hori H, Ota M, Kunugi H (2017) Cerebrospinal fluid neural cell adhesion molecule levels and their correlation with clinical variables in patients with schizophrenia, bipolar disorder, and major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry 76:12\u201318","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2594_CR20","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.neuroscience.2016.06.003","volume":"330","author":"HC Murray","year":"2016","unstructured":"Murray HC, Low VF, Swanson ME, Dieriks BV, Turner C, Faull RL, Curtis MA (2016) Distribution of PSA-NCAM in normal, Alzheimer\u2019s and Parkinson\u2019s disease human brain. Neuroscience 330:359\u2013375","journal-title":"Neuroscience"},{"key":"2594_CR21","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1002\/neu.480260315","volume":"26","author":"P Doherty","year":"1995","unstructured":"Doherty P, Fazeli MS, Walsh FS (1995) The neural cell adhesion molecule and synaptic plasticity. J Neurobiol 26:437\u2013446","journal-title":"J Neurobiol"},{"key":"2594_CR22","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.neuint.2010.03.023","volume":"56","author":"S Zhang","year":"2010","unstructured":"Zhang S, Xia YY, Lim HC, Tang FR, Feng ZW (2010) NCAM-mediated locomotor recovery from spinal cord contusion injury involves neuroprotection, axon regeneration, and synaptogenesis. Neurochem Int 56:919\u2013929","journal-title":"Neurochem Int"},{"key":"2594_CR23","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.schres.2017.06.011","volume":"192","author":"H An","year":"2018","unstructured":"An H, Zhou L, Yu Y, Fan H, Fan F, Tan S, Wang Z, Shi ZB, Yang J, Zhang F, Tan X, Huang Y XF (2018) Serum NCAM levels and cognitive deficits in first episode schizophrenia patients versus health controls. Schizophr Res 192:457\u2013458","journal-title":"Schizophr Res"},{"key":"2594_CR24","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1385\/JMN:22:1-2:33","volume":"22","author":"V Berezin","year":"2004","unstructured":"Berezin V, Bock E (2004) NCAM mimetic peptides: pharmacological and therapeutic potential. J Mol Neurosci 22:33\u201339","journal-title":"J Mol Neurosci"},{"key":"2594_CR25","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/978-1-4419-1170-4_21","volume":"663","author":"V Berezin","year":"2010","unstructured":"Berezin V, Bock E (2010) NCAM mimetic peptides: an update. Adv Exp Med Biol 663:337\u2013353","journal-title":"Adv Exp Med Biol"},{"key":"2594_CR26","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1208\/s12248-014-9578-7","volume":"16","author":"R Xu","year":"2014","unstructured":"Xu R, Feyeux M, Julien S, Nemes C, Albrechtsen M, Dinny\u00e9s A, Krause K-H (2014) Screening of bioactive peptides using an embryonic stem cell-based neurodifferentiation assay. AAPS J 16:400\u2013412","journal-title":"AAPS J"},{"key":"2594_CR27","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.euprot.2014.05.003","volume":"4","author":"T Uhlig","year":"2014","unstructured":"Uhlig T, Kyprianou T, Martinelli FG, Oppici CA, Heiligers D, Hills D, Calvo XR, Verhaert P (2014) The emergence of peptides in the pharmaceutical business: from exploration to exploitation. EuPA Open Proteomics 4:58\u201369","journal-title":"EuPA Open Proteomics"},{"key":"2594_CR28","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1089\/jmf.2014.0028","volume":"18","author":"Y Li","year":"2015","unstructured":"Li Y, Yu J (2015) Research progress in structure-activity relationship of bioactive peptides. J Med Food 18:147\u2013156","journal-title":"J Med Food"},{"key":"2594_CR29","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.biotechadv.2011.01.001","volume":"29","author":"D Agyei","year":"2011","unstructured":"Agyei D, Danquah MK (2011) Industrial-scale manufacturing of pharmaceutical-grade bioactive peptides. Biotechnol Adv 29:272\u2013277","journal-title":"Biotechnol Adv"},{"key":"2594_CR30","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1046\/j.1471-4159.2000.0750665.x","volume":"75","author":"LCB R\u00f8nn","year":"2000","unstructured":"R\u00f8nn LCB, Doherty P, Holm A, Berezin V, Bock E (2000) Neurite outgrowth induced by a synthetic peptide ligand of neural cell adhesion molecule requires fibroblast growth factor receptor activation. J Neurochem 75:665\u2013671","journal-title":"J Neurochem"},{"key":"2594_CR31","doi-asserted-by":"publisher","first-page":"12325","DOI":"10.1074\/jbc.M211628200","volume":"278","author":"D Kiryushko","year":"2003","unstructured":"Kiryushko D, Kofoed T, Skladchikova G, Holm A, Berezin V, Bock E (2003) A synthetic peptide ligand of neural cell adhesion molecule (NCAM), C3d, promotes neuritogenesis and synaptogenesis and modulates presynaptic function in primary cultures of rat hippocampal neurons. J Biol Chem 278:12325\u201312334","journal-title":"J Biol Chem"},{"key":"2594_CR32","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1038\/13697","volume":"17","author":"LCB Ronn","year":"1999","unstructured":"Ronn LCB, Olsen M, Ostergaard S, Kiselyov V, Berezin V, Mortensen MT, Lerche MH, Jensen PH, Soroka V, Saffells JL, Doherty P, Poulsen FM, Bock E, Holm A (1999) Identification of a neuritogenic ligand of the neural cell adhesion molecule using a combinatorial library of synthetic peptides. Nat Biotech 17:1000\u20131005","journal-title":"Nat Biotech"},{"key":"2594_CR33","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1046\/j.1471-4159.2003.01538.x","volume":"84","author":"DK Ditlevsen","year":"2003","unstructured":"Ditlevsen DK, K\u00f8hler LB, Pedersen MV, Risell M, Kolkova K, Meyer M, Berezin V, Bock E (2003) The role of phosphatidylinositol 3-kinase in neural cell adhesion molecule-mediated neuronal differentiation and survival. J Neurochem 84:546\u2013556","journal-title":"J Neurochem"},{"key":"2594_CR34","doi-asserted-by":"publisher","first-page":"015004","DOI":"10.1088\/1748-6041\/9\/1\/015004","volume":"9","author":"M Mie","year":"2014","unstructured":"Mie M, Sasaki S, Kobatake E (2014) Construction of a bFGF-tethered multi-functional extracellular matrix protein through coiled-coil structures for neurite outgrowth induction. Biomed Mater 9:015004","journal-title":"Biomed Mater"},{"key":"2594_CR35","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.pain.2007.09.020","volume":"137","author":"A Sakai","year":"2008","unstructured":"Sakai A, Asada M, Seno N, Suzuki H (2008) Involvement of neural cell adhesion molecule signaling in glial cell line-derived neurotrophic factor-induced analgesia in a rat model of neuropathic pain. Pain 137:378\u2013388","journal-title":"Pain"},{"key":"2594_CR36","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/S0736-5748(02)00086-2","volume":"20","author":"B Klementiev","year":"2002","unstructured":"Klementiev B, Bichevaja N, Novikova T, Chebotar N, Bock E, Berezin V (2002) A peptide agonist of the neural cell adhesion molecule (NCAM), C3, protects against developmental defects induced by a teratogen pyrimethamine. Int J Dev Neurosci 20:527\u2013536","journal-title":"Int J Dev Neurosci"},{"key":"2594_CR37","doi-asserted-by":"publisher","first-page":"2607","DOI":"10.1046\/j.1471-4159.2000.0742607.x","volume":"74","author":"AG Foley","year":"2000","unstructured":"Foley AG, Hartz BP, Gallagher HC, Ronn LC, Berezin V, Bock E, Regan CM (2000) A synthetic peptide ligand of neural cell adhesion molecule (NCAM) IgI domain prevents NCAM internalization and disrupts passive avoidance learning. J Neurochem 74:2607\u20132613","journal-title":"J Neurochem"},{"key":"2594_CR38","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/S0091-3057(03)00155-2","volume":"75","author":"BP Hartz","year":"2003","unstructured":"Hartz BP, S\u00f8hoel A, Berezin V, Bock E, Scheel-Kr\u00fcger J (2003) A synthetic peptide ligand of NCAM affects exploratory behavior and memory in rodents. Pharmacol Biochem Behav 75:861\u2013867","journal-title":"Pharmacol Biochem Behav"},{"key":"2594_CR39","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0306-4522(03)00597-9","volume":"122","author":"K Cambon","year":"2003","unstructured":"Cambon K, Venero C, Berezin V, Bock E, Sandi C (2003) Post-training administration of a synthetic peptide ligand of the neural cell adhesion molecule, C3d, attenuates long-term expression of contextual fear conditioning. Neuroscience 122:183\u2013191","journal-title":"Neuroscience"},{"key":"2594_CR40","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1002\/jnr.22380","volume":"88","author":"LB Kohler","year":"2010","unstructured":"Kohler LB, Soroka V, Korshunova I, Berezin V, Bock E (2010) A peptide derived from a trans-homophilic binding site in neural cell adhesion molecule induces neurite outgrowth and neuronal survival. J Neurosci Res 88:2165\u20132176","journal-title":"J Neurosci Res"},{"key":"2594_CR41","doi-asserted-by":"publisher","first-page":"e23433","DOI":"10.1371\/journal.pone.0023433","volume":"6","author":"I Kraev","year":"2011","unstructured":"Kraev I, Henneberger C, Rossetti C, Conboy L, Kohler LB, Fantin M, Jennings A, Venero C, Popov V, Rusakov D, Stewart MG, Bock E, Berezin V, Sandi C (2011) A peptide mimetic targeting trans-homophilic NCAM binding sites promotes spatial learning and neural plasticity in the hippocampus. PLoS ONE 6:e23433","journal-title":"PLoS ONE"},{"key":"2594_CR42","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.neulet.2011.07.010","volume":"501","author":"C Zellinger","year":"2011","unstructured":"Zellinger C, Hadamitzky M, Bock E, Berezin V, Potschka H (2011) Impact of the NCAM derived mimetic peptide plannexin on the acute cellular consequences of a status epilepticus. Neurosci Lett 501:173\u2013178","journal-title":"Neurosci Lett"},{"key":"2594_CR43","doi-asserted-by":"publisher","first-page":"4197","DOI":"10.1523\/JNEUROSCI.0436-04.2004","volume":"24","author":"K Cambon","year":"2004","unstructured":"Cambon K, Hansen SM, Venero C, Herrero AI, Skibo G, Berezin V, Bock E, Sandi C (2004) A synthetic neural cell adhesion molecule mimetic peptide promotes synaptogenesis, enhances presynaptic function, and facilitates memory consolidation. J Neurosci 24:4197\u20134204","journal-title":"J Neurosci"},{"key":"2594_CR44","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1101\/lm.2154311","volume":"18","author":"G Dallerac","year":"2011","unstructured":"Dallerac G, Zerwas M, Novikova T, Callu D, Leblanc-Veyrac P, Bock E, Berezin V, Rampon C, Doyere V (2011) The neural cell adhesion molecule-derived peptide FGL facilitates long-term plasticity in the dentate gyrus in vivo. Learn Mem 18:306\u2013313","journal-title":"Learn Mem"},{"key":"2594_CR45","doi-asserted-by":"publisher","first-page":"e1001262","DOI":"10.1371\/journal.pbio.1001262","volume":"10","author":"S Knafo","year":"2012","unstructured":"Knafo S, Venero C, Sanchez-Puelles C, Pereda-Perez I, Franco A, Sandi C, Suarez LM, Solis JM, Alonso-Nanclares L, Martin ED, Merino-Serrais P, Borcel E, Li S, Chen Y, Gonzalez-Soriano J, Berezin V, Bock E, Defelipe J, Esteban JA (2012) Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement. PLoS Biol 10:e1001262","journal-title":"PLoS Biol"},{"key":"2594_CR46","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1111\/j.1471-4159.2009.06076.x","volume":"109","author":"EJ Downer","year":"2009","unstructured":"Downer EJ, Cowley TR, Cox F, Maher FO, Berezin V, Bock E, Lynch MA (2009) A synthetic NCAM-derived mimetic peptide, FGL, exerts anti-inflammatory properties via IGF-1 and interferon-gamma modulation. J Neurochem 109:1516\u20131525","journal-title":"J Neurochem"},{"key":"2594_CR47","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.expneurol.2011.09.025","volume":"232","author":"B Ojo","year":"2011","unstructured":"Ojo B, Rezaie P, Gabbott PL, Cowely TR, Medvedev NI, Lynch MA, Stewart MG (2011) A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus. Exp Neurol 232:318\u2013328","journal-title":"Exp Neurol"},{"key":"2594_CR48","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.neuroscience.2012.12.030","volume":"235","author":"FF Cox","year":"2013","unstructured":"Cox FF, Berezin V, Bock E, Lynch MA (2013) The neural cell adhesion molecule-derived peptide, FGL, attenuates lipopolysaccharide-induced changes in glia in a CD200-dependent manner. Neuroscience 235:141\u2013148","journal-title":"Neuroscience"},{"key":"2594_CR49","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1111\/j.1460-9568.2005.04345.x","volume":"22","author":"GG Skibo","year":"2005","unstructured":"Skibo GG, Lushnikova IV, Voronin KY, Dmitrieva O, Novikova T, Klementiev B, Vaudano E, Berezin VA, Bock E (2005) A synthetic NCAM-derived peptide, FGL, protects hippocampal neurons from ischemic insult both in vitro and in vivo. Eur J Neurosci 22:1589\u20131596","journal-title":"Eur J Neurosci"},{"key":"2594_CR50","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.neulet.2008.03.070","volume":"437","author":"MV Pedersen","year":"2008","unstructured":"Pedersen MV, Helweg-Larsen RB, Nielsen FC, Berezin V, Bock E, Penkowa M (2008) The synthetic NCAM-derived peptide, FGL, modulates the transcriptional response to traumatic brain injury. Neurosci Lett 437:148\u2013153","journal-title":"Neurosci Lett"},{"key":"2594_CR51","doi-asserted-by":"publisher","first-page":"e71479","DOI":"10.1371\/journal.pone.0071479","volume":"8","author":"NJ Corbett","year":"2013","unstructured":"Corbett NJ, Gabbott PL, Klementiev B, Davies HA, Colyer FM, Novikova T, Stewart MG (2013) Amyloid-beta induced CA1 pyramidal cell loss in young adult rats is alleviated by systemic treatment with FGL, a neural cell adhesion molecule-derived mimetic peptide. PLoS ONE 8:e71479","journal-title":"PLoS ONE"},{"key":"2594_CR52","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/j.neuroscience.2006.04.059","volume":"141","author":"T Secher","year":"2006","unstructured":"Secher T, Novitskaia V, Berezin V, Bock E, Glenthoj B, Klementiev B (2006) A neural cell adhesion molecule-derived fibroblast growth factor receptor agonist, the FGL-peptide, promotes early postnatal sensorimotor development and enhances social memory retention. Neuroscience 141:1289\u20131299","journal-title":"Neuroscience"},{"key":"2594_CR53","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.brainres.2008.05.088","volume":"1224","author":"CA Turner","year":"2008","unstructured":"Turner CA, Gula EL, Taylor LP, Watson SJ, Akil H (2008) Antidepressant-like effects of intracerebroventricular FGF2 in rats. Brain Res 1224:63\u201368","journal-title":"Brain Res"},{"key":"2594_CR54","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.bbr.2008.12.012","volume":"199","author":"T Secher","year":"2009","unstructured":"Secher T, Berezin V, Bock E, Glenthoj B (2009) Effect of an NCAM mimetic peptide FGL on impairment in spatial learning and memory after neonatal phencyclidine treatment in rats. Behav Brain Res 199:288\u2013297","journal-title":"Behav Brain Res"},{"key":"2594_CR55","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s12015-014-9512-5","volume":"10","author":"R Klein","year":"2014","unstructured":"Klein R, Blaschke S, Neumaier B, Endepols H, Graf R, Keuters M, Hucklenbroich J, Albrechtsen M, Rees S, Fink GR, Schroeter M, Rueger MA (2014) The synthetic NCAM mimetic peptide FGL mobilizes neural stem cells in vitro and in vivo. Stem Cell Rev 10:539\u2013547","journal-title":"Stem Cell Rev"},{"key":"2594_CR56","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1007\/s11481-016-9694-5","volume":"11","author":"R Klein","year":"2016","unstructured":"Klein R, Mahlberg N, Ohren M, Ladwig A, Neumaier B, Graf R, Hoehn M, Albrechtsen M, Rees S, Fink GR, Rueger MA, Schroeter M (2016) The neural cell adhesion molecule-derived (NCAM)-peptide FG loop (FGL) mobilizes endogenous neural stem cells and promotes endogenous regenerative capacity after stroke. J Neuroimmune Pharmacol 11:708\u2013720","journal-title":"J Neuroimmune Pharmacol"},{"key":"2594_CR57","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1111\/j.1471-4159.2005.03417.x","volume":"95","author":"AA Anderson","year":"2005","unstructured":"Anderson AA, Kendal CE, Garcia-Maya M, Kenny AV, Morris-Triggs SA, Wu T, Reynolds R, Hohenester E, Saffell JL (2005) A peptide from the first fibronectin domain of NCAM acts as an inverse agonist and stimulates FGF receptor activation, neurite outgrowth and survival. J Neurochem 95:570\u2013583","journal-title":"J Neurochem"},{"key":"2594_CR58","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1007\/s11064-008-9680-2","volume":"33","author":"J Jacobsen","year":"2008","unstructured":"Jacobsen J, Kiselyov V, Bock E, Berezin V (2008) A peptide Motif from the second fibronectin module of the neural cell adhesion molecule, NCAM, NLIKQDDGGSPIRHY, is a binding site for the FGF receptor. Neurochem Res 33:2532\u20132539","journal-title":"Neurochem Res"},{"key":"2594_CR59","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/j.1471-4159.2005.03338.x","volume":"95","author":"N Kulahin","year":"2005","unstructured":"Kulahin N, Rudenko O, Kiselyov V, Poulsen FM, Berezin V, Bock E (2005) Modulation of the homophilic interaction between the first and second Ig modules of neural cell adhesion molecule by heparin. J Neurochem 95:46\u201355","journal-title":"J Neurochem"},{"key":"2594_CR60","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1046\/j.1460-9568.2002.02242.x","volume":"16","author":"LCB Ronn","year":"2002","unstructured":"Ronn LCB, Olsen M, Soroka V, Ostergaard S, Dissing S, Poulsen FM, Holm A, Berezin V, Bock E (2002) Characterization of a novel NCAM ligand with a stimulatory effect on neurite outgrowth identified by screening a combinatorial peptide library. Eur J Neurosci 16:1720\u20131730","journal-title":"Eur J Neurosci"},{"key":"2594_CR61","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.ejcb.2010.07.007","volume":"89","author":"LB Kohler","year":"2010","unstructured":"Kohler LB, Christensen C, Rossetti C, Fantin M, Sandi C, Bock E, Berezin V (2010) Dennexin peptides modeled after the homophilic binding sites of the neural cell adhesion molecule (NCAM) promote neuronal survival, modify cell adhesion and impair spatial learning. Eur J Cell Biol 89:817\u2013827","journal-title":"Eur J Cell Biol"},{"key":"2594_CR62","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/S0969-2126(03)00096-0","volume":"11","author":"VV Kiselyov","year":"2003","unstructured":"Kiselyov VV, Skladchikova G, Hinsby AM, Jensen PH, Kulahin N, Soroka V, Pedersen N, Tsetlin V, Poulsen FM, Berezin V, Bock E (2003) Structural basis for a direct interaction between FGFR1 and NCAM and evidence for a regulatory role of ATP. Structure 11:691\u2013701","journal-title":"Structure"},{"key":"2594_CR63","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1002\/jnr.22374","volume":"88","author":"Y Chen","year":"2010","unstructured":"Chen Y, Li S, Berezin V, Bock E (2010) The fibroblast growth factor receptor (FGFR) agonist FGF1 and the neural cell adhesion molecule-derived peptide FGL activate FGFR substrate 2alpha differently. J Neurosci Res 88:1882\u20131889","journal-title":"J Neurosci Res"},{"key":"2594_CR64","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.cytogfr.2005.01.007","volume":"16","author":"L Dailey","year":"2005","unstructured":"Dailey L, Ambrosetti D, Mansukhani A, Basilico C (2005) Mechanisms underlying differential responses to FGF signaling. Cytokine Growth Factor Rev 16:233\u2013247","journal-title":"Cytokine Growth Factor Rev"},{"key":"2594_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2009.11.003","volume":"1309","author":"A Aonurm-Helm","year":"2010","unstructured":"Aonurm-Helm A, Berezin V, Bock E, Zharkovsky A (2010) NCAM-mimetic, FGL peptide, restores disrupted fibroblast growth factor receptor (FGFR) phosphorylation and FGFR mediated signaling in neural cell adhesion molecule (NCAM)-deficient mice. Brain Res 1309:1\u20138","journal-title":"Brain Res"},{"key":"2594_CR66","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.neuroscience.2006.11.060","volume":"145","author":"B Klementiev","year":"2007","unstructured":"Klementiev B, Novikova T, Novitskaya V, Walmod PS, Dmytriyeva O, Pakkenberg B, Berezin V, Bock E (2007) A neural cell adhesion molecule-derived peptide reduces neuropathological signs and cognitive impairment induced by Abeta25-35. Neuroscience 145:209\u2013224","journal-title":"Neuroscience"},{"key":"2594_CR67","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1111\/j.1471-4159.2004.02422.x","volume":"89","author":"RV Bhat","year":"2004","unstructured":"Bhat RV, Budd Haeberlein SL, Avila J (2004) Glycogen synthase kinase 3: a drug target for CNS therapies. J Neurochem 89:1313\u20131317","journal-title":"J Neurochem"},{"key":"2594_CR68","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.neurobiolaging.2008.03.017","volume":"31","author":"EJ Downer","year":"2010","unstructured":"Downer EJ, Cowley TR, Lyons A, Mills KH, Berezin V, Bock E, Lynch MA (2010) A novel anti-inflammatory role of NCAM-derived mimetic peptide, FGL. Neurobiol Aging 31:118\u2013128","journal-title":"Neurobiol Aging"},{"key":"2594_CR69","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/j.1460-9568.2007.06004.x","volume":"27","author":"VI Popov","year":"2008","unstructured":"Popov VI, Medvedev NI, Kraev IV, Gabbott PL, Davies HA, Lynch M, Cowley TR, Berezin V, Bock E, Stewart MG (2008) A cell adhesion molecule mimetic, FGL peptide, induces alterations in synapse and dendritic spine structure in the dentate gyrus of aged rats: a three-dimensional ultrastructural study. Eur J Neurosci 27:301\u2013314","journal-title":"Eur J Neurosci"},{"key":"2594_CR70","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1097\/FBP.0b013e3282f3fca9","volume":"19","author":"E Borcel","year":"2008","unstructured":"Borcel E, Perez-Alvarez L, Herrero AI, Brionne T, Varea E, Berezin V, Bock E, Sandi C, Venero C (2008) Chronic stress in adulthood followed by intermittent stress impairs spatial memory and the survival of newborn hippocampal cells in aging animals: prevention by FGL, a peptide mimetic of neural cell adhesion molecule. Behav Pharmacol 19:41\u201349","journal-title":"Behav Pharmacol"},{"key":"2594_CR71","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1111\/j.1460-9568.2008.06471.x","volume":"28","author":"A Aonurm-Helm","year":"2008","unstructured":"Aonurm-Helm A, Jurgenson M, Zharkovsky T, Sonn K, Berezin V, Bock E, Zharkovsky A (2008) Depression-like behaviour in neural cell adhesion molecule (NCAM)-deficient mice and its reversal by an NCAM-derived peptide, FGL. Eur J Neurosci 28:1618\u20131628","journal-title":"Eur J Neurosci"},{"key":"2594_CR72","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2165\/00003088-200746040-00007","volume":"46","author":"R Anand","year":"2007","unstructured":"Anand R, Seiberling M, Kamtchoua T, Pokorny R (2007) Tolerability, safety and pharmacokinetics of the FGLL peptide, a novel mimetic of neural cell adhesion molecule, following intranasal administration in healthy volunteers. Clin Pharmacokinet 46:351\u2013358","journal-title":"Clin Pharmacokinet"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-018-2594-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-018-2594-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-018-2594-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T03:59:19Z","timestamp":1720411159000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-018-2594-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,12]]},"references-count":72,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["2594"],"URL":"https:\/\/doi.org\/10.1007\/s11064-018-2594-8","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,12]]},"assertion":[{"value":"22 January 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}