{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:29:43Z","timestamp":1759616983712,"version":"3.37.3"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100010590","name":"Tianjin Municipal Health Bureau","doi-asserted-by":"publisher","award":["16KG157"],"award-info":[{"award-number":["16KG157"]}],"id":[{"id":"10.13039\/501100010590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1007\/s11064-018-2699-0","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T10:43:38Z","timestamp":1544697818000},"page":"465-471","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Systemic Rapamycin Attenuates Morphine-Induced Analgesic Tolerance and Hyperalgesia in Mice"],"prefix":"10.1007","volume":"44","author":[{"given":"Jun","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4080-0331","authenticated-orcid":false,"given":"Xin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,12,13]]},"reference":[{"key":"2699_CR1","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jpsychires.2014.08.009","volume":"59","author":"G Yu","year":"2014","unstructured":"Yu G, Zhang FQ, Tang SE, Lai MJ, Su RB, Gong ZH (2014) Continuous infusion versus intermittent bolus dosing of morphine: a comparison of analgesia, tolerance, and subsequent voluntary morphine intake. J Psychiatr Res 59:161\u2013166","journal-title":"J Psychiatr Res"},{"key":"2699_CR2","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1097\/MJT.0b013e3181ed83a0","volume":"17","author":"MH Bekhit","year":"2010","unstructured":"Bekhit MH (2010) Opioid-induced hyperalgesia and tolerance. Am J Ther 17:498\u2013510","journal-title":"Am J Ther"},{"key":"2699_CR3","doi-asserted-by":"publisher","first-page":"5260","DOI":"10.2741\/3596","volume":"14","author":"H Ueda","year":"2009","unstructured":"Ueda H, Ueda M (2009) Mechanisms underlying morphine analgesic tolerance and dependence. Front Biosci (Landmark Ed) 14:5260\u20135272","journal-title":"Front Biosci (Landmark Ed)"},{"key":"2699_CR4","doi-asserted-by":"publisher","first-page":"10276","DOI":"10.1073\/pnas.102327699","volume":"99","author":"I Szabo","year":"2002","unstructured":"Szabo I, Chen XH, Xin L, Adler MW, Howard OM, Oppenheim JJ, Rogers TJ (2002) Heterologous desensitization of opioid receptors by chemokines inhibits chemotaxis and enhances the perception of pain. Proc Natl Acad Sci USA 99:10276\u201310281","journal-title":"Proc Natl Acad Sci USA"},{"key":"2699_CR5","doi-asserted-by":"publisher","first-page":"7731","DOI":"10.1073\/pnas.96.14.7731","volume":"96","author":"DJ Mayer","year":"1999","unstructured":"Mayer DJ, Mao J, Holt J, Price DD (1999) Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions. Proc Natl Acad Sci USA 96:7731\u20137736","journal-title":"Proc Natl Acad Sci USA"},{"key":"2699_CR6","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1172\/JCI70236","volume":"124","author":"JT Xu","year":"2014","unstructured":"Xu JT, Zhou X, Zhao X, Ligons D, Tiwari V, Lee CY, Atianjoh FE, Liang L, Zang W, Njoku D, Raja SN, Yaster M, Tao YX (2014) Opioid receptor-triggered spinal mTORC1 activation contributes to morphine tolerance and hyperalgesia. J Clin Invest 124:592\u2013603","journal-title":"J Clin Invest"},{"key":"2699_CR7","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.bbapap.2007.08.015","volume":"1784","author":"L Swiech","year":"2008","unstructured":"Swiech L, Perycz M, Malik A, Jaworski J (2008) Role of mTOR in physiology and pathology of the nervous system. Biochim Biophys Acta 1784:116\u2013132","journal-title":"Biochim Biophys Acta"},{"key":"2699_CR8","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1101\/gad.887201","volume":"15","author":"AC Gingras","year":"2001","unstructured":"Gingras AC, Raught B, Sonenberg N (2001) Regulation of translation initiation by FRAP\/mTOR. Genes Dev 15:807\u2013826","journal-title":"Genes Dev"},{"key":"2699_CR9","first-page":"27","volume":"2","author":"JT Xu","year":"2015","unstructured":"Xu JT, Sun L, Lutz BM, Bekker A, Tao YX (2015) Intrathecal rapamycin attenuates morphine-induced analgesic tolerance and hyperalgesia in rats with neuropathic pain. Transl Perioper Pain Med 2:27\u201334","journal-title":"Transl Perioper Pain Med"},{"key":"2699_CR10","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12990-015-0030-5","volume":"11","author":"BM Lutz","year":"2015","unstructured":"Lutz BM, Nia S, Xiong M, Tao YX, Bekker A (2015) mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesia. Mol Pain 11:32","journal-title":"Mol Pain"},{"key":"2699_CR11","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1016\/j.ctrv.2012.12.012","volume":"39","author":"R Danesi","year":"2013","unstructured":"Danesi R, Boni JP, Ravaud A (2013) Oral and intravenously administered mTOR inhibitors for metastatic renal cell carcinoma: pharmacokinetic considerations and clinical implications. Cancer Treat Rev 39:784\u2013792","journal-title":"Cancer Treat Rev"},{"key":"2699_CR12","doi-asserted-by":"crossref","first-page":"174480691668224","DOI":"10.1177\/1744806916682242","volume":"12","author":"L Liang","year":"2016","unstructured":"Liang L, Zhao JY, Gu X, Wu S, Mo K, Xiong M, Bekker A, Tao YX (2016) G9a inhibits CREB-triggered expression of mu opioid receptor in primary sensory neurons following peripheral nerve injury. Mol Pain 12:1744806916682242","journal-title":"Mol Pain"},{"key":"2699_CR13","doi-asserted-by":"publisher","first-page":"14712","DOI":"10.1038\/ncomms14712","volume":"8","author":"JY Zhao","year":"2016","unstructured":"Zhao JY, Liang L, Gu X, Li Z, Wu S, Sun L, Atianjoh FE, Feng J, Mo K, Jia S, Lutz BM, Bekker A, Nestler EJ, Tao YX (2016) DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nat. Commun 8:14712","journal-title":"Nat. Commun"},{"key":"2699_CR14","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.neuron.2008.10.055","volume":"61","author":"M Costa-Mattioli","year":"2009","unstructured":"Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N (2009) Translational control of long-lasting synaptic plasticity and memory. Neuron 61:10\u201326","journal-title":"Neuron"},{"key":"2699_CR15","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1002\/bip.20254","volume":"80","author":"MH Ossipov","year":"2005","unstructured":"Ossipov MH, Lai J, King T, Vanderah TW, Porreca F (2005) Underlying mechanisms of pronociceptive consequences of prolonged morphine exposure. Biopolymers 80:319\u2013324","journal-title":"Biopolymers"},{"key":"2699_CR16","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.brainres.2010.04.010","volume":"1336","author":"JT Xu","year":"2010","unstructured":"Xu JT, Zhao X, Yaster M, Tao YX (2010) Expression and distribution of mTOR, p70S6K, 4E-BP1, and their phosphorylated counterparts in rat dorsal root ganglion and spinal cord dorsal horn. Brain Res 1336:46\u201357","journal-title":"Brain Res"},{"key":"2699_CR17","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.brainres.2013.04.003","volume":"1513","author":"L Liang","year":"2013","unstructured":"Liang L, Tao B, Fan L, Yaster M, Zhang Y, Tao YX (2013) mTOR and its downstream pathway are activated in the dorsal root ganglion and spinal cord after peripheral inflammation, but not after nerve injury. Brain Res 1513:17\u201325","journal-title":"Brain Res"},{"key":"2699_CR18","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/j.neuron.2011.10.012","volume":"72","author":"MS Mazei-Robison","year":"2011","unstructured":"Mazei-Robison MS, Koo JW, Friedman AK, Lansink CS, Robison AJ, Vinish M, Krishnan V, Kim S, Siuta MA, Galli A, Niswender KD, Appasani R, Horvath MC, Neve RL, Worley PF, Snyder SH, Hurd YL, Cheer JF, Han MH, Russo SJ, Nestler EJ (2011) Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons. Neuron 72:977\u2013990","journal-title":"Neuron"},{"key":"2699_CR19","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.neuroscience.2010.08.064","volume":"171","author":"Y Cui","year":"2010","unstructured":"Cui Y, Zhang XQ, Cui Y, Xin WJ, Jing J, Liu XG (2010) Activation of phosphatidylinositol 3-kinase\/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine-induced place preference in rats. Neuroscience 171:134\u2013143","journal-title":"Neuroscience"},{"key":"2699_CR20","volume-title":"Rapamycin prescribing information","author":"United States Food and Drug Administration","year":"2015","unstructured":"United States Food and Drug Administration (2015) Rapamycin prescribing information. Wyeth Pharmaceuticals, Inc., Philadelphia"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-018-2699-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-018-2699-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-018-2699-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,12]],"date-time":"2019-12-12T19:22:37Z","timestamp":1576178557000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-018-2699-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,13]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["2699"],"URL":"https:\/\/doi.org\/10.1007\/s11064-018-2699-0","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"type":"print","value":"0364-3190"},{"type":"electronic","value":"1573-6903"}],"subject":[],"published":{"date-parts":[[2018,12,13]]},"assertion":[{"value":"30 August 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that there are no conflicts of interest with respect to the research, authorship, and\/or publication of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}