{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:55:00Z","timestamp":1788432900575,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s11064-019-02720-9","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T17:16:58Z","timestamp":1547140618000},"page":"874-883","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Morphine Dependence is Attenuated by Treatment of 3,4,5-Trimethoxy Cinnamic Acid in Mice and Rats"],"prefix":"10.1007","volume":"44","author":[{"given":"Sohyeon","family":"Moon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungmin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heeyeon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taddesse","family":"Yayeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bongjun","family":"Sur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seikwan","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"2720_CR1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/0014-2999(94)90755-2","volume":"253","author":"LH Gold","year":"1994","unstructured":"Gold LH, Stinus L, Inturrisi CE, Koob GF (1994) Prolonged tolerance, dependence and abstinence following subcutaneous morphine pellet implantation in the rat. Eur J Pharmacol 253:45\u201351","journal-title":"Eur J Pharmacol"},{"key":"2720_CR2","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/S0893-133X(01)00226-3","volume":"25","author":"EF Espejo","year":"2001","unstructured":"Espejo EF, Serrano MI, Caille S, Stinus L (2001) Behavioral expression of opiate withdrawal is altered after prefrontocortical dopamine depletion in rats: monoaminergic correlates. Neuropsychopharmacology 25:204\u2013212","journal-title":"Neuropsychopharmacology"},{"key":"2720_CR3","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.neuron.2004.12.049","volume":"45","author":"EE Bagley","year":"2005","unstructured":"Bagley EE, Gerke MB, Vaughan CW, Hack SP, Christie MJ (2005) GABA transporter currents activated by protein kinase A excite midbrain neurons during opioid withdrawal. Neuron 45:433\u2013445","journal-title":"Neuron"},{"key":"2720_CR4","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/0014-2999(92)90052-6","volume":"215","author":"C Done","year":"1992","unstructured":"Done C, Silverstone P, Sharp T (1992) Effect of naloxone-precipitated morphine withdrawal on noradrenaline release in rat hippocampus in vivo. Eur J Pharmacol 215:333\u2013336","journal-title":"Eur J Pharmacol"},{"key":"2720_CR5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1097\/00002826-199104000-00003","volume":"14","author":"J Lipp","year":"1991","unstructured":"Lipp J (1991) Possible mechanisms of morphine analgesia. Clin Neuropharmacol 14:131\u2013147","journal-title":"Clin Neuropharmacol"},{"key":"2720_CR6","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1196\/annals.1300.028","volume":"1003","author":"EH Chartoff","year":"2003","unstructured":"Chartoff EH, Papadopoulou M, Konradi C, Carlezon WA Jr (2003) Effects of naloxone-precipitated morphine withdrawal on glutamate-mediated signaling in striatal neurons in vitro. Ann NY Acad Sci 1003:368\u2013371","journal-title":"Ann NY Acad Sci"},{"key":"2720_CR7","doi-asserted-by":"publisher","first-page":"645","DOI":"10.14348\/molcells.2016.0137","volume":"39","author":"J Kim","year":"2016","unstructured":"Kim J, Ham S, Hong H, Moon C, Im HI (2016) Brain reward circuits in morphine addiction. Mol Cells 39:645\u2013653","journal-title":"Mol Cells"},{"key":"2720_CR8","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.brainres.2015.12.039","volume":"1645","author":"EJ Nestler","year":"2016","unstructured":"Nestler EJ (2016) Reflections on: a general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function. Brain Res 1645:71\u201374","journal-title":"Brain Res"},{"key":"2720_CR9","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1111\/bph.12703","volume":"172","author":"TA Macey","year":"2015","unstructured":"Macey TA, Bobeck EN, Suchland KL, Morgan MM, Ingram SL (2015) Change in functional selectivity of morphine with the development of antinociceptive tolerance. Br J Pharmacol 172:549\u2013561","journal-title":"Br J Pharmacol"},{"key":"2720_CR10","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1111\/j.1460-9568.2004.03656.x","volume":"20","author":"SE Slack","year":"2004","unstructured":"Slack SE, Pezet S, McMahon SB, Thompson SW, Malcangio M (2004) Brain-derived neurotrophic factor induces NMDA receptor subunit one phosphorylation via ERK and PKC in the rat spinal cord. Eur J Neurosci 20:1769\u20131778","journal-title":"Eur J Neurosci"},{"key":"2720_CR11","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1124\/jpet.115.227629","volume":"355","author":"EM Anderson","year":"2015","unstructured":"Anderson EM, Reeves T, Kapernaros K, Neubert JK, Caudle RM (2015) Phosphorylation of the N-methyl-d-aspartate receptor is increased in the nucleus accumbens during both acute and extended morphine withdrawal. J Pharmacol Exp Ther 355:496\u2013505","journal-title":"J Pharmacol Exp Ther"},{"key":"2720_CR12","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1016\/j.neuroscience.2005.09.039","volume":"137","author":"HC Brenhouse","year":"2006","unstructured":"Brenhouse HC, Stellar JR (2006) c-Fos and deltaFosB expression are differentially altered in distinct subregions of the nucleus accumbens shell in cocaine-sensitized rats. Neuroscience 137:773\u2013780","journal-title":"Neuroscience"},{"key":"2720_CR13","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.ejphar.2014.10.034","volume":"753","author":"EJ Nestler","year":"2015","unstructured":"Nestler EJ (2015) FosB: a transcriptional regulator of stress and antidepressant responses. Eur J Pharmacol 753:66\u201372","journal-title":"Eur J Pharmacol"},{"key":"2720_CR14","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.biopsych.2011.08.011","volume":"71","author":"JW Muschamp","year":"2012","unstructured":"Muschamp JW, Nemeth CL, Robison AJ, Nestler EJ, Carlezon WA Jr (2012) DeltaFosB enhances the rewarding effects of cocaine while reducing the pro-depressive effects of the kappa-opioid receptor agonist U50488. Biol Psychiatry 71:44\u201350","journal-title":"Biol Psychiatry"},{"key":"2720_CR15","doi-asserted-by":"publisher","first-page":"466","DOI":"10.2174\/157340607781745465","volume":"3","author":"L Ye","year":"2007","unstructured":"Ye L, Zhang W (2007) Synthesis and biological activity of 3-(2, 8, 9-trioxa-aza-1-germatricyclo [3. 3. 3. 0]undecane-1-yl)-hydroxycinnamic acids. Med Chem 3:466\u2013468","journal-title":"Med Chem"},{"key":"2720_CR16","doi-asserted-by":"publisher","first-page":"13919","DOI":"10.1074\/jbc.M213041200","volume":"278","author":"K Burhenne","year":"2003","unstructured":"Burhenne K, Kristensen BK, Rasmussen SK (2003) A new class of N-hydroxycinnamoyltransferases. Purification, cloning, and expression of a barley agmatine coumaroyltransferase (EC 2.3.1.64). J Biol Chem 278:13919\u201313927","journal-title":"J Biol Chem"},{"key":"2720_CR17","doi-asserted-by":"publisher","first-page":"31891","DOI":"10.1074\/jbc.M704257200","volume":"282","author":"BL Henry","year":"2007","unstructured":"Henry BL, Monien BH, Bock PE, Desai UR (2007) A novel allosteric pathway of thrombin inhibition: exosite II mediated potent inhibition of thrombin by chemo-enzymatic, sulfated dehydropolymers of 4-hydroxycinnamic acids. J Biol Chem 282:31891\u201331899","journal-title":"J Biol Chem"},{"key":"2720_CR18","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1248\/bpb.27.1317","volume":"27","author":"K Kawashima","year":"2004","unstructured":"Kawashima K, Miyako D, Ishino Y, Makino T, Saito K, Kano Y (2004) Anti-stress effects of 3,4,5-trimethoxycinnamic acid, an active constituent of roots of Polygala tenuifolia (Onji). Biol Pharm Bull 27:1317\u20131319","journal-title":"Biol Pharm Bull"},{"key":"2720_CR19","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3109\/14756360902932784","volume":"25","author":"JC Jung","year":"2010","unstructured":"Jung JC, Min D, Kim H, Jang S, Lee Y, Park W, Khan IA, Moon HI, Jung M, Oh S (2010) Design, synthesis, and biological evaluation of 3,4,5-trimethoxyphenyl acrylamides as antinarcotic agents. J Enzyme Inhib Med Chem 25:38\u201343","journal-title":"J Enzyme Inhib Med Chem"},{"key":"2720_CR20","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/cbdd.12087","volume":"81","author":"JC Jung","year":"2013","unstructured":"Jung JC, Moon S, Min D, Park WK, Jung M, Oh S (2013) Synthesis and evaluation of a series of 3,4,5-trimethoxycinnamic acid derivatives as potential antinarcotic agents. Chem Biol Drug Des 81:389\u2013398","journal-title":"Chem Biol Drug Des"},{"key":"2720_CR21","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.jgr.2016.08.006","volume":"40","author":"T Yayeh","year":"2016","unstructured":"Yayeh T, Yun K, Jang S, Oh S (2016) Morphine dependence is attenuated by red ginseng extract and ginsenosides Rh2, Rg3, and compound K. J Ginseng Res 40:445\u2013452","journal-title":"J Ginseng Res"},{"key":"2720_CR22","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1007\/s12272-016-0773-1","volume":"40","author":"J Yun","year":"2017","unstructured":"Yun J, Oliynyk S, Lee Y, Kim J, Yun K, Jeon R, Ryu JH, Oh S (2017) Ajoene restored behavioral patterns and liver glutathione level in morphine treated C57BL6 mice. Arch Pharm Res 40:106\u2013111","journal-title":"Arch Pharm Res"},{"key":"2720_CR23","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1038\/s41598-018-21915-8","volume":"8","author":"F Wang","year":"2018","unstructured":"Wang F, Meng J, Zhang L, Johnson T, Chen C, Roy S (2018) Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model. Sci Rep 8:3596","journal-title":"Sci Rep"},{"key":"2720_CR24","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1007\/s12272-014-0534-y","volume":"38","author":"J Yun","year":"2015","unstructured":"Yun J, Lee Y, Yun K, Oh S (2015) Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice. Arch Pharm Res 38:1248\u20131254","journal-title":"Arch Pharm Res"},{"key":"2720_CR25","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.neulet.2014.11.016","volume":"585","author":"YH Leem","year":"2015","unstructured":"Leem YH, Oh S (2015) 3,4,5-Trimethoxycinnamin acid ameliorates restraint stress-induced anxiety and depression. Neurosci Lett 585:54\u201359","journal-title":"Neurosci Lett"},{"key":"2720_CR26","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1111\/cns.12244","volume":"20","author":"N Shen","year":"2014","unstructured":"Shen N, Mo LQ, Hu F, Chen PX, Guo RX, Feng JQ (2014) A novel role of spinal astrocytic connexin 43: mediating morphine antinociceptive tolerance by activation of NMDA receptors and inhibition of glutamate transporter-1 in rats. CNS Neurosci Ther 20:728\u2013736","journal-title":"CNS Neurosci Ther"},{"key":"2720_CR27","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s12640-011-9250-2","volume":"20","author":"F Li","year":"2011","unstructured":"Li F, Wang XS, Dai RP, Zhang JY, Zhou XF, Hao W, Li CQ (2011) The activation of NMDA receptor-ERK pathway in the central amygdala is required for the expression of morphine-conditioned place preference in the rat. Neurotox Res 20:362\u2013371","journal-title":"Neurotox Res"},{"key":"2720_CR28","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1111\/j.1369-1600.2011.00373.x","volume":"17","author":"F Li","year":"2012","unstructured":"Li F, Wu N, Su R, Chen Y, Lu X, Liu Y, Li J (2012) Imidazoline receptor antisera-selected\/Nischarin regulates the effect of agmatine on the development of morphine dependence. Addict Biol 17:392\u2013408","journal-title":"Addict Biol"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-019-02720-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-019-02720-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-019-02720-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:05:59Z","timestamp":1578614759000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-019-02720-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,10]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["2720"],"URL":"https:\/\/doi.org\/10.1007\/s11064-019-02720-9","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,10]]},"assertion":[{"value":"30 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}