{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:40:39Z","timestamp":1790361639213,"version":"4.1.0"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"(Comit\u00e9 para el Desarrollo y la Investigaci\u00f3n-CODI, Universidad de Antioquia-UdeA)","award":["2545"],"award-info":[{"award-number":["2545"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1007\/s11064-019-02835-z","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T09:06:01Z","timestamp":1563181561000},"page":"1986-1998","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Neuroprotective Effects of Methanolic Extract of Avocado Persea americana (var. Colinred) Peel on Paraquat-Induced Locomotor Impairment, Lipid Peroxidation and Shortage of Life Span in Transgenic knockdown Parkin Drosophila melanogaster"],"prefix":"10.1007","volume":"44","author":[{"given":"Hector Flavio","family":"Ortega-Arellano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlene","family":"Jimenez-Del-Rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0557-0411","authenticated-orcid":false,"given":"Carlos","family":"Velez-Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"issue":"Suppl 1","key":"2835_CR1","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1111\/jnc.13691","volume":"139","author":"S Sveinbjornsdottir","year":"2016","unstructured":"Sveinbjornsdottir S (2016) The clinical symptoms of Parkinson's disease. J Neurochem 139(Suppl 1):318\u2013324. \n                              https:\/\/doi.org\/10.1111\/jnc.13691","journal-title":"J Neurochem"},{"key":"2835_CR2","doi-asserted-by":"publisher","first-page":"91","DOI":"10.3389\/fnana.2015.00091","volume":"9","author":"J Blesa","year":"2015","unstructured":"Blesa J, Trigo-Damas I, Quiroga-Varela A, Jackson-Lewis VR (2015) Oxidative stress and Parkinson's disease. Front Neuroanat 9:91. \n                              https:\/\/doi.org\/10.3389\/fnana.2015.00091","journal-title":"Front Neuroanat"},{"key":"2835_CR3","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1002\/jcph.1008","volume":"58","author":"LD Coles","year":"2018","unstructured":"Coles LD, Tuite PJ, \u00d6z G, Mishra UR, Kartha RV, Sullivan KM, Cloyd JC, Terpstra M (2018) Repeated-dose oral N-Acetylcysteine in Parkinson's disease: pharmacokinetics and effect on brain glutathione and oxidative stress. J Clin Pharmacol 58:158\u2013167. \n                              https:\/\/doi.org\/10.1002\/jcph.1008","journal-title":"J Clin Pharmacol"},{"key":"2835_CR4","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1089\/acm.2017.0387","volume":"24","author":"SH Park","year":"2018","unstructured":"Park SH, Hwang MS, Park HJ, Shin HK, Baek JU, Choi BT (2018) Herbal prescriptions and medicinal herbs for parkinson-related rigidity in Korean medicine: identification of candidates using text mining. J Altern Complement Med 24:733\u2013740. \n                              https:\/\/doi.org\/10.1089\/acm.2017.0387","journal-title":"J Altern Complement Med"},{"key":"2835_CR5","doi-asserted-by":"publisher","first-page":"260","DOI":"10.2174\/1570159X13666151030102718","volume":"14","author":"R Filograna","year":"2016","unstructured":"Filograna R, Beltramini M, Bubacco L, Bisaglia M (2016) Anti-oxidants in Parkinson's disease therapy: a critical point of view. Curr Neuropharmacol 14:260\u2013271. \n                              https:\/\/doi.org\/10.2174\/1570159X13666151030102718","journal-title":"Curr Neuropharmacol"},{"key":"2835_CR6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1186\/s13041-017-0340-9","volume":"10","author":"L Puspita","year":"2017","unstructured":"Puspita L, Chung SY, Shim JW (2017) Oxidative stress and cellular pathologies in Parkinson's disease. Mol Brain 10:53. \n                              https:\/\/doi.org\/10.1186\/s13041-017-0340-9","journal-title":"Mol Brain"},{"key":"2835_CR7","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13643-017-0491-x","volume":"6","author":"C Vaccari","year":"2017","unstructured":"Vaccari C, El Dib R, de Camargo JLV (2017) Paraquat and Parkinson's disease: a systematic review protocol according to the OHAT approach for hazard identification. Syst Rev 6:98. \n                              https:\/\/doi.org\/10.1186\/s13643-017-0491-x","journal-title":"Syst Rev"},{"key":"2835_CR8","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1093\/ije\/dyx225","volume":"47","author":"C Pouchieu","year":"2018","unstructured":"Pouchieu C, Piel C, Carles C, Gruber A, Helmer C, Tual S, Marcotullio E, Lebailly P, Baldi I (2018) Pesticide use in agriculture and Parkinson's disease in the AGRICAN cohort study. Int J Epidemiol 47:299\u2013310. \n                              https:\/\/doi.org\/10.1093\/ije\/dyx225","journal-title":"Int J Epidemiol"},{"key":"2835_CR9","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1007\/s11064-011-0451-0","volume":"36","author":"HF Ortega-Arellano","year":"2011","unstructured":"Ortega-Arellano HF, Jimenez-Del-Rio M, Velez-Pardo C (2011) Life span and locomotor activity modification by glucose and polyphenols in Drosophila melanogaster chronically exposed to oxidative stress-stimuli: implications in Parkinson's disease. Neurochem Res 36:1073\u20131086. \n                              https:\/\/doi.org\/10.1007\/s11064-011-0451-0","journal-title":"Neurochem Res"},{"key":"2835_CR10","doi-asserted-by":"publisher","first-page":"3310","DOI":"10.1007\/s11064-017-2373-y","volume":"42","author":"S Niveditha","year":"2017","unstructured":"Niveditha S, Ramesh SR, Shivanandappa T (2017) Paraquat-induced movement disorder in relation to oxidative stress-mediated neurodegeneration in the brain of Drosophila melanogaster. Neurochem Res 42:3310\u20133320. \n                              https:\/\/doi.org\/10.1007\/s11064-017-2373-y","journal-title":"Neurochem Res"},{"key":"2835_CR11","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.gene.2010.04.009","volume":"462","author":"E Lavara-Culebras","year":"2010","unstructured":"Lavara-Culebras E, Mu\u00f1oz-Soriano V, G\u00f3mez-Pastor R, Matallana E, Paricio N (2010) Effects of pharmacological agents on the lifespan phenotype of Drosophila DJ-1beta mutants. Gene 462:26\u201333. \n                              https:\/\/doi.org\/10.1016\/j.gene.2010.04.009","journal-title":"Gene"},{"key":"2835_CR12","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/jnc.12818","volume":"131","author":"JA Navarro","year":"2014","unstructured":"Navarro JA, He\u00dfner S, Yenisetti SC, Bayersdorfer F, Zhang L, Voigt A, Schneuwly S, Botella JA (2014) Analysis of dopaminergic neuronal dysfunction in genetic and toxin-induced models of Parkinson's disease in Drosophila. J Neurochem 131:369\u2013382. \n                              https:\/\/doi.org\/10.1111\/jnc.12818","journal-title":"J Neurochem"},{"key":"2835_CR13","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.3892\/ijmm.2018.3406","volume":"41","author":"JD Guo","year":"2018","unstructured":"Guo JD, Zhao X, Li Y, Li GR, Liu XL (2018) Damage to dopaminergic neurons by oxidative stress in Parkinson's disease (Review). Int J Mol Med 41:1817\u20131825. \n                              https:\/\/doi.org\/10.3892\/ijmm.2018.3406","journal-title":"Int J Mol Med"},{"key":"2835_CR14","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.gene.2012.09.120","volume":"512","author":"L Bonilla-Ramirez","year":"2013","unstructured":"Bonilla-Ramirez L, Jimenez-Del-Rio M, Velez-Pardo C (2013) Low doses of paraquat and polyphenols prolong life span and locomotor activity in knock-down parkin Drosophila melanogaster exposed to oxidative stress stimuli: implication in autosomal recessive juvenile parkinsonism. Gene 512:355\u2013363. \n                              https:\/\/doi.org\/10.1016\/j.gene.2012.09.120","journal-title":"Gene"},{"key":"2835_CR15","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.neuro.2017.03.002","volume":"60","author":"HF Ortega-Arellano","year":"2017","unstructured":"Ortega-Arellano HF, Jimenez-Del-Rio M, Velez-Pardo C (2017) Minocycline protects, rescues and prevents knockdown transgenic parkin Drosophila against paraquat\/iron toxicity: implications for autosomic recessive juvenile parkinsonism. Neurotoxicology 60:42\u201353. \n                              https:\/\/doi.org\/10.1016\/j.neuro.2017.03.002","journal-title":"Neurotoxicology"},{"key":"2835_CR16","doi-asserted-by":"publisher","DOI":"10.1039\/C9MD00099B","author":"U Maitra","year":"2019","unstructured":"Maitra U, Ciesla L (2019) Using Drosophila as a platform for drug discovery from natural products in Parkinson\u2019s disease. Med Chem Commun. \n                              https:\/\/doi.org\/10.1039\/C9MD00099B","journal-title":"Med Chem Commun"},{"key":"2835_CR17","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s12640-018-9899-x","volume":"34","author":"DA Martinez-Perez","year":"2018","unstructured":"Martinez-Perez DA, Jimenez-Del-Rio M, Velez-Pardo C (2018) Epigallocatechin-3-gallate protects and prevents paraquat-induced oxidative stress and neurodegeneration in knockdown dj-1-\u03b2 Drosophila melanogaster. Neurotox Res 34:401\u2013416. \n                              https:\/\/doi.org\/10.1007\/s12640-018-9899-x","journal-title":"Neurotox Res"},{"key":"2835_CR18","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1093\/jhered\/esn068","volume":"100","author":"H Chen","year":"2009","unstructured":"Chen H, Morrell PL, Ashworth VETM, de la Cruz M, Clegg MT (2009) Tracing the geographic origins of major avocado cultivars. J Heredity 100:56\u201365. \n                              https:\/\/doi.org\/10.1093\/jhered\/esn068","journal-title":"J Heredity"},{"key":"2835_CR19","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1079\/9781845937010.0010","volume-title":"The avocado: botany, production and uses","author":"JB Bost","year":"2013","unstructured":"Bost JB, Smith NJH, Crane JH (2013) History, distribution and uses. In: Schaffer B, Nigel Wolstenholme B, Whiley AW (eds) The avocado: botany, production and uses, 2nd edn. CAB International, Boston, pp 10\u201330","edition":"2"},{"key":"2835_CR20","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/j.foodchem.2010.03.114","volume":"122","author":"W Wang","year":"2010","unstructured":"Wang W, Bostic TR, Gu LW (2010) Antioxidant capacities, procyanidins and pigments in avocados of different strains and cultivars. Food Chem 122:1193\u20131198. \n                              https:\/\/doi.org\/10.1016\/j.foodchem.2010.03.114","journal-title":"Food Chem"},{"key":"2835_CR21","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.semcancer.2007.04.003","volume":"17","author":"H Ding","year":"2007","unstructured":"Ding H, Chin YW, Kinghorn AD, D'Ambrosio SM (2007) Chemopreventive characteristics of avocado fruit. Semin Cancer Biol 17:386\u2013394. \n                              https:\/\/doi.org\/10.1016\/j.semcancer.2007.04.003","journal-title":"Semin Cancer Biol"},{"key":"2835_CR22","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1002\/anie.201000044","volume":"50","author":"S Quideau","year":"2011","unstructured":"Quideau S, Deffieux D, Douat-Casassus C, Pouys\u00e9gu L (2011) Plant polyphenols: chemical properties, biological activities, and synthesis. Angew Chem Int Ed Engl 50:586\u2013621. \n                              https:\/\/doi.org\/10.1002\/anie.201000044","journal-title":"Angew Chem Int Ed Engl"},{"key":"2835_CR23","doi-asserted-by":"publisher","first-page":"1768","DOI":"10.1016\/j.biotechadv.2017.12.001","volume":"36","author":"SF Nabavi","year":"2017","unstructured":"Nabavi SF, Sureda A, Dehpour AR, Shirooie S, Silva AS, Devi KP, Ahmed T, Ishaq N, Hashim R, Sobarzo-S\u00e1nchez E, Daglia M, Braidy N, Volpicella M, Vacca RA, Nabavi SM (2017) Regulation of autophagy by polyphenols: paving the road for treatment of neurodegeneration. Biotechnol Adv 36:1768\u20131778. \n                              https:\/\/doi.org\/10.1016\/j.biotechadv.2017.12.001","journal-title":"Biotechnol Adv"},{"key":"2835_CR24","doi-asserted-by":"publisher","first-page":"e0192577","DOI":"10.1371\/journal.pone.0192577","volume":"13","author":"MA Tremocoldi","year":"2018","unstructured":"Tremocoldi MA, Rosalen PL, Franchin M, Massarioli AP, Denny C, Daiuto \u00c9R, Paschoal JAR, Melo PS, Alencar SM (2018) Exploration of avocado by-products as natural sources of bioactive compounds. PLoS ONE 13:e0192577. \n                              https:\/\/doi.org\/10.1371\/journal.pone.0192577","journal-title":"PLoS ONE"},{"key":"2835_CR25","doi-asserted-by":"publisher","first-page":"E642","DOI":"10.3390\/nu10050642","volume":"10","author":"M Kujawska","year":"2018","unstructured":"Kujawska M, Jodynis-Liebert J (2018) Polyphenols in Parkinson\u2019s disease: a systematic review of in vivo studies. Nutrients 10:E642. \n                              https:\/\/doi.org\/10.3390\/nu10050642","journal-title":"Nutrients"},{"key":"2835_CR26","doi-asserted-by":"publisher","first-page":"5625","DOI":"10.1021\/jf1048832","volume":"59","author":"JG Rodr\u00edguez-Carpena","year":"2011","unstructured":"Rodr\u00edguez-Carpena JG, Morcuende D, Andrade MJ, Kylli P, Est\u00e9vez M (2011) Avocado (Persea americana Mill.) phenolics, in vitro antioxidant and antimicrobial activities, and inhibition of lipid and protein oxidation in porcine patties. J Agric Food Chem 59:5625\u20135635. \n                              https:\/\/doi.org\/10.1021\/jf1048832","journal-title":"J Agric Food Chem"},{"key":"2835_CR27","doi-asserted-by":"publisher","first-page":"4613","DOI":"10.1021\/jf300090p","volume":"9","author":"A Kosi\u0144ska","year":"2012","unstructured":"Kosi\u0144ska A, Karama\u0107 M, Estrella I, Hern\u00e1ndez T, Bartolom\u00e9 B, Dykes GA (2012) Phenolic compound profiles and antioxidant capacity of Persea americana Mill. peels and seeds of two varieties. J Agric Food Chem 9:4613\u20134619. \n                              https:\/\/doi.org\/10.1021\/jf300090p","journal-title":"J Agric Food Chem"},{"key":"2835_CR28","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.lwt.2015.07.048","volume":"65","author":"M Calderon-Oliver","year":"2016","unstructured":"Calderon-Oliver M, Escalona-Buend\u00eda HB, Medina-Campos ON, Pedraza-Chaverri J, Pedroza-Islas R, Ponce-Alquicira E (2016) Optimization of the antioxidant and antimicrobial response of the combined effect of nisin and avocado byproducts. LWT Food Sci Technol 65:46\u201352. \n                              https:\/\/doi.org\/10.1016\/j.lwt.2015.07.048","journal-title":"LWT Food Sci Technol"},{"issue":"11","key":"2835_CR29","doi-asserted-by":"publisher","first-page":"E3343","DOI":"10.3390\/ijms19113343","volume":"19","author":"E Nagoshi","year":"2011","unstructured":"Nagoshi E (2011) Drosophila models of Sporadic Parkinson's disease. Int J Mol Sci 19(11):E3343. \n                              https:\/\/doi.org\/10.3390\/ijms19113343","journal-title":"Int J Mol Sci"},{"key":"2835_CR30","doi-asserted-by":"publisher","first-page":"250","DOI":"10.5483\/BMBRep.2019.52.4.204","volume":"52","author":"B Aryal","year":"2019","unstructured":"Aryal B, Lee Y (2019) Disease model organism for Parkinson disease: Drosophila melanogaster. BMB Rep 52:250\u2013258","journal-title":"BMB Rep"},{"key":"2835_CR31","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/S0076-6879(99)99017-1","volume":"299","author":"VL Singleton","year":"1999","unstructured":"Singleton VL, Orthofer R, Lamuela-Raventos RM (1999) Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent. Methods Enzymol 299:152\u2013178","journal-title":"Methods Enzymol"},{"key":"2835_CR32","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1021\/jf203353h","volume":"60","author":"R \u00c1lvarez","year":"2012","unstructured":"\u00c1lvarez R, Carvalho C, Sierra J, Lara O, Cardona D, Londono-Londo\u00f1o J (2012) Citrus juice extraction systems: effect on chemical composition and antioxidant activity of clementine juice. J Agric Food Chem 60:774\u2013781. \n                              https:\/\/doi.org\/10.1021\/jf203353h","journal-title":"J Agric Food Chem"},{"key":"2835_CR33","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.jfca.2006.01.003","volume":"19","author":"K Thaipong","year":"2006","unstructured":"Thaipong K, Boonprakoba U, Crosbyb K, Cisneros-Zevallosc L, Hawkins-Byrnec D (2006) Comparison of ABTS, DPPH, FRAP, and ORAC assays for estimating antioxidant activity from guava fruit extracts. J Food Comp Anal 19:669\u2013675. \n                              https:\/\/doi.org\/10.1016\/j.jfca.2006.01.003","journal-title":"J Food Comp Anal"},{"key":"2835_CR34","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1021\/jf9807768","volume":"47","author":"IFF Benzie","year":"1999","unstructured":"Benzie IFF, Szeto YT (1999) Total antioxidant capacity of teas by the ferric reducing\/antioxidant power assay. J Agric Food Chem 47:633\u2013636","journal-title":"J Agric Food Chem"},{"key":"2835_CR35","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s12161-016-0610-7","volume":"10","author":"L Carrillo-Hormaza","year":"2017","unstructured":"Carrillo-Hormaza L, Ram\u00edrez AM, Osorio E, Gil A (2017) Optimization of ultrasound-assisted extraction and rapid resolution analysis of flavanols and methylxanthines for the quality control of cocoa-derived products. Food Anal Methods 10:497\u2013507. \n                              https:\/\/doi.org\/10.1007\/s12161-016-0610-7","journal-title":"Food Anal Methods"},{"key":"2835_CR36","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1079\/9781845937010.0200","volume-title":"The avocado: botany, production and uses","author":"JH Crane","year":"2013","unstructured":"Crane JH, Douhan G, Faber BA, Arpaia ML, Bender GS, Balerdi CF, Barrientos-Priego AF (2013) Cultivars and rootstocks. In: Schaffer B, Nigel Wolstenholme B, Whiley AW (eds) The avocado: botany, production and uses, 2nd edn. CAB International, Boston, pp 200\u2013233","edition":"2"},{"key":"2835_CR37","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3923\/rjmp.2017.55.61","volume":"11","author":"I Antasionasti","year":"2017","unstructured":"Antasionasti I, Riyanto S, Rohman A (2017) Antioxidant activities and phenolics contents of avocado (Persea americana Mill.) peel in vitro. Res J Medic Plants 11:55\u201361. \n                              https:\/\/doi.org\/10.3923\/rjmp.2017.55.61","journal-title":"Res J Medic Plants"},{"key":"2835_CR38","first-page":"167","volume":"5","author":"SR Smitha Grace","year":"2015","unstructured":"Smitha Grace SR, Chauhan JB, Jain CR (2015) Preliminary phytochemical investigation and tlc analysis of peel and seed extracts of Persea americana. Asian J Pharmac Sci Technol 5:167\u2013171","journal-title":"Asian J Pharmac Sci Technol"},{"key":"2835_CR39","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1002\/ptr.5643","volume":"30","author":"S Eghbaliferiz","year":"2016","unstructured":"Eghbaliferiz S, Iranshahi M (2016) Prooxidant activity of polyphenols, flavonoids, anthocyanins and carotenoids: updated review of mechanisms and catalyzing metals. Phytother Res 30:1379\u20131391. \n                              https:\/\/doi.org\/10.1002\/ptr.5643","journal-title":"Phytother Res"},{"key":"2835_CR40","doi-asserted-by":"publisher","first-page":"e0165575","DOI":"10.1371\/journal.pone.0165575","volume":"11","author":"SA Cherrak","year":"2016","unstructured":"Cherrak SA, Mokhtari-Soulimane N, Berroukeche F, Bensenane B, Cherbonnel A, Merzouk H, Elhabiri M (2016) In Vitro antioxidant versus metal ion chelating properties of flavonoids: a structure-activity investigation. PLoS ONE 11:e0165575. \n                              https:\/\/doi.org\/10.1371\/journal.pone.0165575","journal-title":"PLoS ONE"},{"key":"2835_CR41","doi-asserted-by":"publisher","first-page":"1273","DOI":"10.1039\/C5FO01244A","volume":"7","author":"L Zhang","year":"2016","unstructured":"Zhang L, Wang Y, Li D, Ho CT, Li J, Wan X (2016) The absorption, distribution, metabolism and excretion of procyanidins. Food Funct 7:1273\u20131281. \n                              https:\/\/doi.org\/10.1039\/c5fo01244a","journal-title":"Food Funct"},{"key":"2835_CR42","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.foodchem.2017.08.117","volume":"241","author":"M Grzesik","year":"2018","unstructured":"Grzesik M, Napar\u0142o K, Bartosz G, Sadowska-Bartosz I (2018) Antioxidant properties of catechins: Comparison with other antioxidants. Food Chem 241:480\u2013492. \n                              https:\/\/doi.org\/10.1016\/j.foodchem.2017.08.117","journal-title":"Food Chem"},{"key":"2835_CR43","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s10534-018-0131-5","volume":"31","author":"J Aaseth","year":"2018","unstructured":"Aaseth J, Dusek P, Roos PM (2018) Prevention of progression in Parkinson's disease. Biometals 31:737\u2013747. \n                              https:\/\/doi.org\/10.1007\/s10534-018-0131-5","journal-title":"Biometals"},{"key":"2835_CR44","unstructured":"R\u00edos-Casta\u00f1o D, Tafur Reyes RV (2003) Variedades de aguacate para el tr\u00f3pico: Caso Colombia. Proceedings V World Avocado Congress 2003 [Actas V Congreso Mundial del Aguacate 2003]. October 19 -24, 2003; Granada - M\u00e1laga, Spain, p. 143-147. (\n                              https:\/\/www.avocadosource.com\/WAC5\/WAC5_TOC.htm\n                              \n                           ; available in April 2019)."},{"key":"2835_CR45","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3389\/fpls.2017.00243","volume":"8","author":"LF Guzman","year":"2017","unstructured":"Guzman LF, Machida-Hirano R, Borrayo E, Cort\u00e9s-Cruz M, Esp\u00edndola-Barquera MD, Heredia-Garc\u00eda E (2017) Genetic structure and selection of a core collection for long term conservation of avocado in Mexico. Front. Plant Sci 8:243. \n                              https:\/\/doi.org\/10.3389\/fpls.2017.00243","journal-title":"Front. Plant Sci"},{"issue":"1","key":"2835_CR46","doi-asserted-by":"publisher","first-page":"E7","DOI":"10.3390\/antiox6010007","volume":"6","author":"GI Hidalgo","year":"2017","unstructured":"Hidalgo GI, Almajano MP (2017) Red fruits: Extraction of antioxidants, phenolic content, and radical scavenging determination: a review. Antioxidants (Basel) 6(1):E7. \n                              https:\/\/doi.org\/10.3390\/antiox6010007","journal-title":"Antioxidants (Basel)"},{"key":"2835_CR47","doi-asserted-by":"publisher","first-page":"10383","DOI":"10.1021\/acs.jafc.7b03614","volume":"65","author":"Q Yuan","year":"2017","unstructured":"Yuan Q, Zhao L (2017) The mulberry (Morus alba L.) fruit-A review of characteristic components and health benefits. J Agric Food Chem 65:10383\u201310394. \n                              https:\/\/doi.org\/10.1021\/acs.jafc.7b03614","journal-title":"J Agric Food Chem"},{"key":"2835_CR48","doi-asserted-by":"publisher","first-page":"620","DOI":"10.3389\/fpls.2019.00620","volume":"10","author":"I Bar-Ya'akov","year":"2019","unstructured":"Bar-Ya'akov I, Tian L, Amir R, Holland D (2019) Primary metabolites, anthocyanins, and hydrolyzable tannins in the pomegranate fruit. Front Plant Sci 10:620. \n                              https:\/\/doi.org\/10.3389\/fpls.2019.00620","journal-title":"Front Plant Sci"},{"key":"2835_CR49","doi-asserted-by":"publisher","first-page":"8204129","DOI":"10.1155\/2019\/8204129","volume":"2019","author":"R Avila-Sosa","year":"2019","unstructured":"Avila-Sosa R, Montero-Rodr\u00edguez AF, Aguilar-Alonso P, Vera-L\u00f3pez O, Lazcano-Hern\u00e1ndez M, Morales-Medina JC, Navarro-Cruz AR (2019) Antioxidant properties of amazonian fruits: a mini review of in vivo and in vitro studies. Oxid Med Cell Longev 2019:8204129. \n                              https:\/\/doi.org\/10.1155\/2019\/8204129","journal-title":"Oxid Med Cell Longev"},{"key":"2835_CR50","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jnutbio.2016.08.014","volume":"39","author":"PS Gu","year":"2017","unstructured":"Gu PS, Moon M, Choi JG, Oh MS (2017) Mulberry fruit ameliorates Parkinson's-disease-related pathology by reducing \u03b1-synuclein and ubiquitin levels in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine\/probenecid model. J Nutr Biochem 39:15\u201321. \n                              https:\/\/doi.org\/10.1016\/j.jnutbio.2016.08.014","journal-title":"J Nutr Biochem"},{"key":"2835_CR51","doi-asserted-by":"publisher","first-page":"4215","DOI":"10.1074\/jbc.RA118.005723","volume":"294","author":"H Mohammad-Beigi","year":"2019","unstructured":"Mohammad-Beigi H, Aliakbari F, Sahin C, Lomax C, Tawfike A, Schafer NP, Amiri-Nowdijeh A, Eskandari H, M\u00f8ller IM, Hosseini-Mazinani M, Christiansen G, Ward JL, Morshedi D, Otzen DE (2019) Oleuropein derivatives from olive fruit extracts reduce \u03b1-synuclein fibrillation and oligomer toxicity. J Biol Chem 294:4215\u20134232. \n                              https:\/\/doi.org\/10.1074\/jbc.RA118.005723","journal-title":"J Biol Chem"},{"key":"2835_CR52","doi-asserted-by":"publisher","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","volume":"3","author":"W Poewe","year":"2017","unstructured":"Poewe W, Seppi K, Tanner CM, Halliday GM, Brundin P, Volkmann J, Schrag AE, Lang AE (2017) Parkinson disease. Nat Rev Dis Primers 3:17013. \n                              https:\/\/doi.org\/10.1038\/nrdp.2017.13","journal-title":"Nat Rev Dis Primers"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-019-02835-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-019-02835-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-019-02835-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T23:36:43Z","timestamp":1594683403000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-019-02835-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,15]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["2835"],"URL":"https:\/\/doi.org\/10.1007\/s11064-019-02835-z","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,15]]},"assertion":[{"value":"9 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 June 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was carried out in accordance with National Legislation for Live Animal Experimentation (Colombia Republic, Resolution 08430, 1993). Experiments with Flies received the approval of the Ethics Committee for Animal Experimentation of the SIU-UdeA (act #83-2013).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}