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Our recent study has shown that pramipexole, a drug efficient in inhibiting parkinsonian tremor, reduced the harmaline-induced tremor in rats, generally accepted to be a model of essential tremor. The aim of the present study was to investigate brain targets for the tremorolytic effect of pramipexole by determination of the early activity-dependent gene <jats:italic>zif-268<\/jats:italic> mRNA expression. Tremor in rats was induced by harmaline administered at a dose of 15\u00a0mg\/kg <jats:italic>ip<\/jats:italic>. Pramipexole was administered at a low dose of 0.1\u00a0mg\/kg <jats:italic>sc<\/jats:italic>. Tremor was measured by Force Plate Actimeters where four force transducers located below the corners of the plate tracked the animal\u2019s position on a Cartesian plane. The <jats:italic>zif-268<\/jats:italic> mRNA expression was analyzed by in situ hybridization in brain slices. Harmaline induced tremor and increased <jats:italic>zif-268<\/jats:italic> mRNA levels in the inferior olive, cerebellar cortex, ventroanterior\/ventrolateral thalamic nuclei and motor cortex. Pramipexole reversed both the harmaline-induced tremor and the increase in <jats:italic>zif-268<\/jats:italic> mRNA expression in the inferior olive, cerebellar cortex and motor cortex. Moreover, the tremor intensity correlated positively with <jats:italic>zif-268<\/jats:italic> mRNA expression in the above structures. The present results seem to suggest that the tremorolytic effect of pramipexole is related to the modulation of the harmaline-increased neuronal activity in the tremor network which includes the inferior olive, cerebellar cortex and motor cortex. Potential mechanisms underlying the above pramipexole action are discussed.<\/jats:p>","DOI":"10.1007\/s11064-020-03010-5","type":"journal-article","created":{"date-parts":[[2020,3,14]],"date-time":"2020-03-14T09:03:04Z","timestamp":1584176584000},"page":"1518-1525","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Pramipexole Reduces zif-268 mRNA Expression in Brain Structures involved in the Generation of Harmaline-Induced Tremor"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4581-6196","authenticated-orcid":false,"given":"Barbara","family":"Kosmowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8381-6632","authenticated-orcid":false,"given":"Krystyna","family":"Ossowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0208-1946","authenticated-orcid":false,"given":"Jadwiga","family":"Wardas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,3,14]]},"reference":[{"key":"3010_CR1","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s11910-013-0353-4","volume":"13","author":"RJ Elble","year":"2013","unstructured":"Elble RJ (2013) What is essential tremor? 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