{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:19:27Z","timestamp":1785280767485,"version":"3.55.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s11064-020-03101-3","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T09:04:09Z","timestamp":1595840649000},"page":"2409-2416","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Beneficial Effects of Ibuprofen on Pentylenetetrazol-induced Convulsion"],"prefix":"10.1007","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4121-8930","authenticated-orcid":false,"given":"Ferit","family":"Duranku\u015f","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evrim","family":"\u015eenkal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eda","family":"S\u00fcnnet\u00e7i","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakup","family":"Albayrak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Beyazy\u00fcz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6z\u00fcm","family":"Atasoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oytun","family":"Erba\u015f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,27]]},"reference":[{"key":"3101_CR1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1056\/NEJMcp0801738","volume":"359","author":"JA French","year":"2008","unstructured":"French JA, Pedley TA (2008) Clinical practice. Initial management of epilepsy. N Engl J Med 359:166\u2013176. https:\/\/doi.org\/10.1056\/NEJMcp0801738","journal-title":"N Engl J Med"},{"key":"3101_CR2","doi-asserted-by":"crossref","unstructured":"Chen H, He H, Xiao Y et al (2019) Losigamone add-on therapy for focal epilepsy. Cochrane Database Syst. Rev. 2019","DOI":"10.1002\/14651858.CD009324.pub5"},{"key":"3101_CR3","doi-asserted-by":"crossref","unstructured":"Gibson AP, Patel NC (2008) Mechanisms of action of antiepileptic drugs. In: Antiepileptic Drugs to Treat Psychiatric Disorders. Taylor and Francis, pp\u00a01\u201315","DOI":"10.3109\/9780849382666.001"},{"key":"3101_CR4","doi-asserted-by":"publisher","first-page":"3406","DOI":"10.1074\/jbc.272.6.3406","volume":"272","author":"JM Lehmann","year":"1997","unstructured":"Lehmann JM, Lenhard JM, Oliver BB et al (1997) Peroxisome proliferator-activated receptors \u03b1 and \u03b3 are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272:3406\u20133410. https:\/\/doi.org\/10.1074\/jbc.272.6.3406","journal-title":"J Biol Chem"},{"key":"3101_CR5","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1124\/jpet.102.041533","volume":"304","author":"KMK Boje","year":"2003","unstructured":"Boje KMK, Jaworowicz D, Raybon JJ (2003) Neuroinflammatory role of prostaglandins during experimental meningitis: Evidence suggestive of an in vivo relationship between nitric oxide and prostaglandins. J Pharmacol Exp Ther 304:319\u2013325. https:\/\/doi.org\/10.1124\/jpet.102.041533","journal-title":"J Pharmacol Exp Ther"},{"key":"3101_CR6","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1111\/apa.12339","volume":"102","author":"TF McElrath","year":"2013","unstructured":"McElrath TF, Allred EN, Van Marter L et al (2013) Perinatal systemic inflammatory responses of growth-restricted preterm newborns. Acta Paediatr Int J Paediatr 102:439\u2013442. https:\/\/doi.org\/10.1111\/apa.12339","journal-title":"Acta Paediatr Int J Paediatr"},{"key":"3101_CR7","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s11095-006-9905-5","volume":"23","author":"JMR Parepally","year":"2006","unstructured":"Parepally JMR, Mandula H, Smith QR (2006) Brain uptake of nonsteroidal anti-inflammatory drugs: Ibuprofen, flurbiprofen, and indomethacin. Pharm Res 23:873\u2013881. https:\/\/doi.org\/10.1007\/s11095-006-9905-5","journal-title":"Pharm Res"},{"key":"3101_CR8","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1542\/peds.2007-0064","volume":"120","author":"H Kokki","year":"2007","unstructured":"Kokki H, Kumpulainen E, Lehtonen M et al (2007) Cerebrospinal fluid distribution of ibuprofen after intravenous administration in children. Pediatrics 120:1002\u20131008. https:\/\/doi.org\/10.1542\/peds.2007-0064","journal-title":"Pediatrics"},{"key":"3101_CR9","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1016\/S0140-6736(02)08424-6","volume":"359","author":"V Gournay","year":"2002","unstructured":"Gournay V, Savagner C, Thiriez G et al (2002) Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants. Lancet 359:1486\u20131488. https:\/\/doi.org\/10.1016\/S0140-6736(02)08424-6","journal-title":"Lancet"},{"key":"3101_CR10","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1080\/08035250410031279","volume":"93","author":"MM Tatli","year":"2004","unstructured":"Tatli MM, Kumral A, Duman N et al (2004) Spontaneous intestinal perforation after oral ibuprofen treatment of patent ductus arteriosus in two very-low-birthweight infants. Acta Paediatr Int J Paediatr 93:999\u20131001. https:\/\/doi.org\/10.1080\/08035250410031279","journal-title":"Acta Paediatr Int J Paediatr"},{"key":"3101_CR11","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/j.1365-2710.2005.00630.x","volume":"30","author":"L Desfrere","year":"2005","unstructured":"Desfrere L, Zohar S, Morville P et al (2005) Dose-finding study of ibuprofen in patent ductus arteriosus using the continual reassessment method. J Clin Pharm Ther 30:121\u2013132. https:\/\/doi.org\/10.1111\/j.1365-2710.2005.00630.x","journal-title":"J Clin Pharm Ther"},{"key":"3101_CR12","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/sj.jp.7211925","volume":"28","author":"MTC Ambat","year":"2008","unstructured":"Ambat MTC, Ostrea EM, Aranda JV (2008) Effect of ibuprofen L-lysinate on bilirubin binding to albumin as measured by saturation index and horseradish peroxidase assays. J Perinatol 28:287\u2013290. https:\/\/doi.org\/10.1038\/sj.jp.7211925","journal-title":"J Perinatol"},{"key":"3101_CR13","doi-asserted-by":"crossref","unstructured":"Ohlsson A, Shah PS (2018) Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. Cochrane Database Syst. Rev. 2018","DOI":"10.1002\/14651858.CD010061.pub3"},{"key":"3101_CR14","doi-asserted-by":"publisher","first-page":"5675","DOI":"10.1113\/JP275428","volume":"596","author":"JA Wixey","year":"2018","unstructured":"Wixey JA, Chand KK, Pham L et al (2018) Therapeutic potential to reduce brain injury in growth restricted newborns. J Physiol 596:5675\u20135686","journal-title":"J Physiol"},{"key":"3101_CR15","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1093\/cercor\/bht431","volume":"25","author":"NP,G A","year":"2015","unstructured":"A NP,G, M. B, et al (2015) Brain Growth Gains and Losses in Extremely Preterm Infants at Term. Cereb Cortex 25:1897\u20131905","journal-title":"Cereb Cortex"},{"key":"3101_CR16","doi-asserted-by":"publisher","first-page":"2566","DOI":"10.1007\/s11064-019-02875-5","volume":"44","author":"J Peng","year":"2019","unstructured":"Peng J, Wu S, Guo C et al (2019) Effect of Ibuprofen on Autophagy of Astrocytes During Pentylenetetrazol-Induced Epilepsy and its Significance: An Experimental Study. Neurochem Res 44:2566\u20132576. https:\/\/doi.org\/10.1007\/s11064-019-02875-5","journal-title":"Neurochem Res"},{"key":"3101_CR17","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.peptides.2012.12.003","volume":"40","author":"O Erbas","year":"2013","unstructured":"Erbas O, Yilmaz M, Korkmaz HA et al (2013) Oxytocin inhibits pentylentetrazol-induced seizures in the rat. Peptides 40:141\u2013144. https:\/\/doi.org\/10.1016\/j.peptides.2012.12.003","journal-title":"Peptides"},{"key":"3101_CR18","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1179\/1743132814Y.0000000391","volume":"37","author":"O Erba\u015f","year":"2015","unstructured":"Erba\u015f O, Solmaz V, Aksoy D (2015) Inhibitor effect of dexketoprofen in rat model of pentylenetetrazol-induced seizures. Neurol Res 37:1096\u20131101. https:\/\/doi.org\/10.1179\/1743132814Y.0000000391","journal-title":"Neurol Res"},{"key":"3101_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","volume":"65","author":"NC Danbolt","year":"2001","unstructured":"Danbolt NC (2001) Glutamate uptake (review, online-version). Prog Neurobiol 65:1\u2013105","journal-title":"Prog Neurobiol"},{"key":"3101_CR20","first-page":"788","volume":"54","author":"M Kalani","year":"2016","unstructured":"Kalani M, Shariat M, Khalesi N et al (2016) A comparison of early ibuprofen and indomethacin administration to prevent intraventricular hemorrhage among preterm infants. Acta Med Iran 54:788\u2013792","journal-title":"Acta Med Iran"},{"key":"3101_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jconrel.2017.08.011","volume":"264","author":"S Liu","year":"2017","unstructured":"Liu S, Pan G, Liu G et al (2017) Electrospun fibrous membranes featuring sustained release of ibuprofen reduce adhesion and improve neurological function following lumbar laminectomy. J Control Release 264:1\u201313. https:\/\/doi.org\/10.1016\/j.jconrel.2017.08.011","journal-title":"J Control Release"},{"key":"3101_CR22","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.neulet.2012.03.037","volume":"515","author":"K Sekiyama","year":"2012","unstructured":"Sekiyama K, Fujita M, Sekigawa A et al (2012) Ibuprofen ameliorates protein aggregation and astrocytic gliosis, but not cognitive dysfunction, in a transgenic mouse expressing dementia with Lewy bodies-linked P123H \u03b2-synuclein. Neurosci Lett 515:97\u2013101. https:\/\/doi.org\/10.1016\/j.neulet.2012.03.037","journal-title":"Neurosci Lett"},{"key":"3101_CR23","doi-asserted-by":"publisher","first-page":"14663","DOI":"10.1074\/jbc.M511089200","volume":"281","author":"K Yoshikawa","year":"2006","unstructured":"Yoshikawa K, Kita Y, Kishimoto K, Shimizu T (2006) Profiling of eicosanoid production in the rat hippocampus during kainic acid-induced seizure: Dual phase regulation and differential involvement of COX-1 AND COX-2. J Biol Chem 281:14663\u201314669. https:\/\/doi.org\/10.1074\/jbc.M511089200","journal-title":"J Biol Chem"},{"key":"3101_CR24","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.nbd.2011.08.007","volume":"45","author":"RJ Claycomb","year":"2012","unstructured":"Claycomb RJ, Hewett SJ, Hewett JA (2012) Neuromodulatory role of endogenous interleukin-1\u03b2 in acute seizures: Possible contribution of cyclooxygenase-2. Neurobiol Dis 45:234\u2013242. https:\/\/doi.org\/10.1016\/j.nbd.2011.08.007","journal-title":"Neurobiol Dis"},{"key":"3101_CR25","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.brainres.2007.12.017","volume":"1193","author":"HJ Kim","year":"2008","unstructured":"Kim HJ, Chung JI, Lee SH et al (2008) Involvement of endogenous prostaglandin F2\u03b1 on kainic acid-induced seizure activity through FP receptor: The mechanism of proconvulsant effects of COX-2 inhibitors. Brain Res 1193:153\u2013161. https:\/\/doi.org\/10.1016\/j.brainres.2007.12.017","journal-title":"Brain Res"},{"key":"3101_CR26","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/j.1528-1167.2011.03326.x","volume":"53","author":"MGSS Salvadori","year":"2012","unstructured":"Salvadori MGSS, Bander\u00f5 CRR, Jesse AC et al (2012) Prostaglandin E 2 potentiates methylmalonate-induced seizures. Epilepsia 53:189\u2013198. https:\/\/doi.org\/10.1111\/j.1528-1167.2011.03326.x","journal-title":"Epilepsia"},{"key":"3101_CR27","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1111\/j.1528-1167.2009.02480.x","volume":"51","author":"A R\u00e9gnier","year":"2010","unstructured":"R\u00e9gnier A, Vicaut E, Mraovitch S (2010) Aggravation of seizure-associated microvascular injuries by ibuprofen may involve multiple pathways. Epilepsia 51:2412\u20132422. https:\/\/doi.org\/10.1111\/j.1528-1167.2009.02480.x","journal-title":"Epilepsia"},{"key":"3101_CR28","doi-asserted-by":"publisher","first-page":"14850","DOI":"10.1523\/JNEUROSCI.3922-11.2011","volume":"31","author":"GE Serrano","year":"2011","unstructured":"Serrano GE, Lelutiu N, Rojas A et al (2011) Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus. J Neurosci 31:14850\u201314860. https:\/\/doi.org\/10.1523\/JNEUROSCI.3922-11.2011","journal-title":"J Neurosci"},{"key":"3101_CR29","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/S0006-8993(99)01797-7","volume":"843","author":"EJ Baik","year":"1999","unstructured":"Baik EJ, Kim EJ, Lee SH, Moon CH (1999) Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus. Brain Res 843:118\u2013129. https:\/\/doi.org\/10.1016\/S0006-8993(99)01797-7","journal-title":"Brain Res"},{"key":"3101_CR30","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.eplepsyres.2010.06.011","volume":"91","author":"L Holtman","year":"2010","unstructured":"Holtman L, Van Vliet EA, Edelbroek PM et al (2010) Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy. Epilepsy Res 91:49\u201356. https:\/\/doi.org\/10.1016\/j.eplepsyres.2010.06.011","journal-title":"Epilepsy Res"},{"key":"3101_CR31","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/BF00313153","volume":"222","author":"D Egg","year":"1980","unstructured":"Egg D, Herold M, Rumpl E, G\u00fcnther R (1980) Prostaglandin F2\u03b1 levels in human cerebrospinal fluid in normal and pathological conditions. J Neurol 222:239\u2013248. https:\/\/doi.org\/10.1007\/BF00313153","journal-title":"J Neurol"},{"key":"3101_CR32","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1385\/JMN:27:3:303","volume":"27","author":"E Candelario-Jalil","year":"2005","unstructured":"Candelario-Jalil E, Slawik H, Ridelis I et al (2005) Regional distribution of the prostaglandin E2 receptor EP1 in the rat brain: Accumulation in Purkinje cells of the cerebellum. J Mol Neurosci 27:303\u2013310. https:\/\/doi.org\/10.1385\/JMN:27:3:303","journal-title":"J Mol Neurosci"},{"key":"3101_CR33","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/0006-8993(87)91360-6","volume":"404","author":"H Baran","year":"1987","unstructured":"Baran H, Heldt R, Hertting G (1987) Increased prostaglandin formation in rat brain following systemic application of kainic acid. Brain Res 404:107\u2013112. https:\/\/doi.org\/10.1016\/0006-8993(87)91360-6","journal-title":"Brain Res"},{"key":"3101_CR34","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/0197-0186(95)80003-4","volume":"27","author":"MG Naffah-Mazzacoratti","year":"1995","unstructured":"Naffah-Mazzacoratti MG, Bell\u00edssimo MI, Cavalheiro EA (1995) Profile of prostaglandin levels in the rat hippocampus in pilocarpine model of epilepsy. Neurochem Int 27:461\u2013466. https:\/\/doi.org\/10.1016\/0197-0186(95)80003-4","journal-title":"Neurochem Int"},{"key":"3101_CR35","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1407-13.2014","author":"R Haba","year":"2014","unstructured":"Haba R, Shintani N, Onaka Y et al (2014) Central CRTH2, a second prostaglandin D2 receptor, mediates emotional impairment in the lipopolysaccharide and tumor-induced sickness behavior model. J Neurosci. https:\/\/doi.org\/10.1523\/JNEUROSCI.1407-13.2014","journal-title":"J Neurosci"},{"key":"3101_CR36","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/S0090-6980(02)00044-8","volume":"68\u201369","author":"K Watanabe","year":"2002","unstructured":"Watanabe K (2002) Prostaglandin F synthase. Prostaglandins Other Lipid Mediat 68\u201369:401\u2013407. https:\/\/doi.org\/10.1016\/S0090-6980(02)00044-8","journal-title":"Prostaglandins Other Lipid Mediat"},{"key":"3101_CR37","doi-asserted-by":"publisher","first-page":"9070","DOI":"10.1073\/pnas.90.19.9070","volume":"90","author":"Y Urade","year":"1993","unstructured":"Urade Y, Kitahama K, Ohishi H et al (1993) Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain. Proc Natl Acad Sci 90:9070\u20139074. https:\/\/doi.org\/10.1073\/pnas.90.19.9070","journal-title":"Proc Natl Acad Sci"},{"key":"3101_CR38","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1056\/NEJM197611042951901","volume":"295","author":"KB Nelson","year":"1976","unstructured":"Nelson KB, Ellenberg JH (1976) Predictors of epilepsy in children who have experienced febrile seizures. N Engl J Med 295:1029\u20131033. https:\/\/doi.org\/10.1056\/NEJM197611042951901","journal-title":"N Engl J Med"},{"key":"3101_CR39","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/S0262-1746(82)80014-0","volume":"9","author":"U F\u00f6rstermann","year":"1982","unstructured":"F\u00f6rstermann U, Neufang B, Hertting G (1982) Rapid and effective conversion of 6-keto-prostaglandin F1\u03b1 to 6,15-diketo-13,14-dihydro-prostaglandin F1\u03b1-immunoreactive material in vivo. Prostaglandins Leukot Med 9:277\u2013284. https:\/\/doi.org\/10.1016\/S0262-1746(82)80014-0","journal-title":"Prostaglandins Leukot Med"},{"key":"3101_CR40","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/S0387-7604(83)80039-4","volume":"5","author":"I Tamai","year":"1983","unstructured":"Tamai I, Takei T, Maekawa K, Ohta H (1983) Prostaglandin F2\u03b1 concentrations in the cerebrospinal fluid of children with febrile convulsions, epilepsy and meningitis. Brain Dev 5:357\u2013362. https:\/\/doi.org\/10.1016\/S0387-7604(83)80039-4","journal-title":"Brain Dev"},{"key":"3101_CR41","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/S0140-6736(73)91094-5","volume":"302","author":"RC Lyneham","year":"1973","unstructured":"Lyneham RC, Mcleod JG, Smith ID et al (1973) Convulsions and electroencephalogram abnormalities after intra-amniotic prostaglandin F2a. Lancet 302:1003\u20131005. https:\/\/doi.org\/10.1016\/S0140-6736(73)91094-5","journal-title":"Lancet"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-020-03101-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-020-03101-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-020-03101-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:01:29Z","timestamp":1627344089000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-020-03101-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,27]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["3101"],"URL":"https:\/\/doi.org\/10.1007\/s11064-020-03101-3","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,27]]},"assertion":[{"value":"15 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 July 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experimental procedures employed in the present study were approved by the Animal Ethics Committee (51879863-59a). Present manuscript was approved by Local Institutional Animal Care and Ethics Committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}