{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:44:18Z","timestamp":1786981458545,"version":"build-2736575974"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","award":["2019TR55"],"award-info":[{"award-number":["2019TR55"]}],"id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Universidade Comunit\u00e1ria da Regi\u00e3o de Chapec\u00f3"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s11064-020-03158-0","type":"journal-article","created":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T12:43:35Z","timestamp":1603802615000},"page":"241-251","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Micronized Resveratrol Shows Anticonvulsant Properties in Pentylenetetrazole-Induced Seizure Model in Adult Zebrafish"],"prefix":"10.1007","volume":"46","author":[{"given":"Emilia Rodrigues","family":"Almeida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1ssia Alves","family":"Lima-Rezende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina Ester","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane","family":"Garbinato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jefferson","family":"Pedroso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Decui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gean Pablo S.","family":"Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liz Girardi","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Vladimir","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Siebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,10,27]]},"reference":[{"key":"3158_CR1","doi-asserted-by":"publisher","first-page":"18024","DOI":"10.1038\/nrdp.2018.24","volume":"4","author":"O Devinsky","year":"2018","unstructured":"Devinsky O, Vezzani A, O\u2019Brien TJ et al (2018) Epilepsy. Nat Rev Dis Primers 4:18024","journal-title":"Nat Rev Dis Primers"},{"key":"3158_CR2","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1111\/epi.12550","volume":"55","author":"RS Fisher","year":"2014","unstructured":"Fisher RS, Acevedo C, Arzimanoglou A et al (2014) ILAE official report: a practical clinical definition of epilepsy. Epilepsia 55:475\u2013482","journal-title":"Epilepsia"},{"key":"3158_CR3","unstructured":"World Health Organization (2020) https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/epilepsy"},{"key":"3158_CR4","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.ncl.2016.06.015","volume":"34","author":"A Singh","year":"2016","unstructured":"Singh A, Trevick S (2016) The epidemiology of global epilepsy. Neurol Clin 34:837\u2013847. https:\/\/doi.org\/10.1016\/j.ncl.2016.06.015","journal-title":"Neurol Clin"},{"key":"3158_CR5","first-page":"5","volume":"97","author":"AT Berg","year":"2006","unstructured":"Berg AT (2006) Defining intractable epilepsy. Adv Neurol 97:5\u201310","journal-title":"Adv Neurol"},{"key":"3158_CR6","doi-asserted-by":"publisher","unstructured":"Berman AY, Motechin RA, Wiesenfeld MY, Holz MK (2017) The therapeutic potential of resveratrol: a review of clinical trials. npj Precis Oncol 1. doi:https:\/\/doi.org\/10.1038\/s41698-017-0038-6","DOI":"10.1038\/s41698-017-0038-6"},{"key":"3158_CR7","unstructured":"E. H. Siemann, L. L. Creasy concentration of the phytoalexin resveratrol in wine"},{"key":"3158_CR8","doi-asserted-by":"crossref","unstructured":"Mishra V, Shuai B, Kodali M, et al (2015) Resveratrol treatment after status epilepticus restrains neurodegeneration and abnormal neurogenesis with suppression of oxidative stress and inflammation. Sci Rep 5. doi:10.1038\/srep17807","DOI":"10.1038\/srep17807"},{"key":"3158_CR9","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1007\/s11064-009-9920-0","volume":"34","author":"Z Wu","year":"2009","unstructured":"Wu Z, Xu Q, Zhang L et al (2009) Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats. Neurochem Res 34:1393\u20131400. https:\/\/doi.org\/10.1007\/s11064-009-9920-0","journal-title":"Neurochem Res"},{"key":"3158_CR10","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/mnfr.200900437","volume":"54","author":"C-H Cottart","year":"2010","unstructured":"Cottart C-H, Nivet-Antoine V, Laguillier-Morizot C, Beaudeux J-L (2010) Resveratrol bioavailability and toxicity in humans. Mol Nutr Food Res 54:7\u201316. https:\/\/doi.org\/10.1002\/mnfr.200900437","journal-title":"Mol Nutr Food Res"},{"key":"3158_CR11","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1590\/S0100-40422003000500012","volume":"26","author":"E Carrilho","year":"2003","unstructured":"Carrilho E, Tavares MCH, Lan\u00e7as FM (2003) Fluidos supercr\u00edticos em qu\u00edmica anal\u00edtica. II. Cromatografia com fluido supercr\u00edtico: instrumenta\u00e7\u00e3o. Qu\u00edmica Nova 26:687\u2013693. https:\/\/doi.org\/10.1590\/S0100-40422003000500012","journal-title":"Qu\u00edmica Nova"},{"key":"3158_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.indcrop.2017.11.008","volume":"112","author":"GPS Aguiar","year":"2018","unstructured":"Aguiar GPS, Arcari BD, Chaves LMPC et al (2018) Micronization of trans-resveratrol by supercritical fluid: dissolution, solubility and in vitro antioxidant activity. Ind Crops Prod 112:1\u20135. https:\/\/doi.org\/10.1016\/j.indcrop.2017.11.008","journal-title":"Ind Crops Prod"},{"key":"3158_CR13","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.ijpharm.2017.02.018","volume":"521","author":"F Kurniawansyah","year":"2017","unstructured":"Kurniawansyah F, Quachie L, Mammucari R, Foster NR (2017) Improving the dissolution properties of curcumin using dense gas antisolvent technology. Int J Pharm 521:239\u2013248. https:\/\/doi.org\/10.1016\/j.ijpharm.2017.02.018","journal-title":"Int J Pharm"},{"key":"3158_CR14","doi-asserted-by":"publisher","first-page":"106243","DOI":"10.1016\/j.eplepsyres.2019.106243","volume":"159","author":"L Decui","year":"2020","unstructured":"Decui L, Garbinato CLL, Schneider SE et al (2020) Micronized resveratrol shows promising effects in a seizure model in zebrafish and signalizes an important advance in epilepsy treatment. Epilepsy Res 159:106243","journal-title":"Epilepsy Res"},{"key":"3158_CR15","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.indcrop.2016.04.047","volume":"89","author":"GPS Aguiar","year":"2016","unstructured":"Aguiar GPS, Boschetto DL, Chaves LMPC et al (2016) Trans-resveratrol micronization by SEDS technique. Ind Crops Prod 89:350\u2013355","journal-title":"Ind Crops Prod"},{"key":"3158_CR16","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.supflu.2017.03.025","volume":"127","author":"C Dal Magro","year":"2017","unstructured":"Dal Magro C, Aguiar GPS, Veneral JG et al (2017) Co-precipitation of trans -resveratrol in PHBV using solution enhanced dispersion by supercritical fluids technique. J Supercrit Fluids 127:182\u2013190","journal-title":"J Supercrit Fluids"},{"key":"3158_CR17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s10646-019-02146-7","volume":"29","author":"F Bevilaqua","year":"2020","unstructured":"Bevilaqua F, Sachett A, Chitolina R et al (2020) A mixture of fipronil and fungicides induces alterations on behavioral and oxidative stress parameters in zebrafish. Ecotoxicology 29:140\u2013147","journal-title":"Ecotoxicology"},{"key":"3158_CR18","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1089\/zeb.2014.1004","volume":"12","author":"AM Siebel","year":"2015","unstructured":"Siebel AM, Menezes FP, Capiotti KM et al (2015) Role of adenosine signaling on pentylenetetrazole-induced seizures in zebrafish. Zebrafish 12:127\u2013136","journal-title":"Zebrafish"},{"key":"3158_CR19","doi-asserted-by":"crossref","unstructured":"Bertoncello KT, Aguiar GPS, Oliveira JV, Siebel AM (2018) Micronization potentiates curcumin\u2019s anti-seizure effect and brings an important advance in epilepsy treatment. Sci Rep 8. doi:10.1038\/s41598-018-20897-x","DOI":"10.1038\/s41598-018-20897-x"},{"key":"3158_CR20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.pbb.2015.05.022","volume":"139","author":"AM Siebel","year":"2015","unstructured":"Siebel AM, Menezes FP, da Costa SI et al (2015) Rapamycin suppresses PTZ-induced seizures at different developmental stages of zebrafish. Pharmacol Biochem Behav 139:163\u2013168","journal-title":"Pharmacol Biochem Behav"},{"key":"3158_CR21","doi-asserted-by":"publisher","first-page":"3242","DOI":"10.1080\/01496395.2019.1675704","volume":"55","author":"CS Dzah","year":"2020","unstructured":"Dzah CS, Duan Y, Zhang H et al (2020) Enhanced screening of key ultrasonication parameters: total phenol content and antioxidant activity assessment of Tartary buckwheat (Fagopyrum tataricum) water extract. Sep Sci Technol 55:3242\u20133251","journal-title":"Sep Sci Technol"},{"key":"3158_CR22","doi-asserted-by":"publisher","first-page":"3012","DOI":"10.3390\/molecules25133012","volume":"25","author":"J Harasym","year":"2020","unstructured":"Harasym J, Satta E, Kaim U (2020) Ultrasound treatment of buckwheat grains impacts important functional properties of resulting flour. Molecules 25:3012","journal-title":"Molecules"},{"key":"3158_CR23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.yebeh.2015.03.019","volume":"45","author":"K Leclercq","year":"2015","unstructured":"Leclercq K, Afrikanova T, Langlois M et al (2015) Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish. Epilepsy Behav 45:53\u201363","journal-title":"Epilepsy Behav"},{"key":"3158_CR24","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.neulet.2016.09.002","volume":"632","author":"F Tomaciello","year":"2016","unstructured":"Tomaciello F, Leclercq K, Kaminski RM (2016) Resveratrol lacks protective activity against acute seizures in mouse models. Neurosci Lett 632:199\u2013203","journal-title":"Neurosci Lett"},{"key":"3158_CR25","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.neuroscience.2004.11.031","volume":"131","author":"SC Baraban","year":"2005","unstructured":"Baraban SC, Taylor MR, Castro PA, Baier H (2005) Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. Neuroscience 131:759\u2013768","journal-title":"Neuroscience"},{"key":"3158_CR26","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1242\/dmm.026922","volume":"10","author":"M van der Vaart","year":"2017","unstructured":"van der Vaart M, Svoboda O, Weijts BG et al (2017) Mecp2 regulates tnfa during zebrafish embryonic development and acute inflammation. Dis Models Mech 10:1439\u20131451","journal-title":"Dis Models Mech"},{"key":"3158_CR27","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1111\/j.1745-7270.2007.00283.x","volume":"39","author":"R Tang","year":"2007","unstructured":"Tang R, Dodd A, Lai D et al (2007) Validation of zebrafish (Danio rerio) reference genes for quantitative Real-time RT-PCR normalization. Acta Biochim Biophys Sin 39:384\u2013390","journal-title":"Acta Biochim Biophys Sin"},{"key":"3158_CR28","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ydbio.2008.04.022","volume":"319","author":"J Mei","year":"2008","unstructured":"Mei J, Zhang Q-Y, Li Z et al (2008) C1q-like inhibits p53-mediated apoptosis and controls normal hematopoiesis during zebrafish embryogenesis. Dev Biol 319:273\u2013284","journal-title":"Dev Biol"},{"key":"3158_CR29","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) analysis of relative gene expression data using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT method. Methods 25:402\u2013408","journal-title":"Methods"},{"key":"3158_CR30","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1111\/j.1558-5646.1989.tb04220.x","volume":"43","author":"WR Rice","year":"1989","unstructured":"Rice WR (1989) Analyzing tables of statistical tests. Evolution 43:223","journal-title":"Evolution"},{"key":"3158_CR31","first-page":"105","volume":"25","author":"P Blardi","year":"1999","unstructured":"Blardi P, De Lalla A, Volpi L, Di Perri T (1999) Stimulation of endogenous adenosine release by oral administration of quercetin and resveratrol in man. Drugs Exp Clin Res 25:105\u2013110","journal-title":"Drugs Exp Clin Res"},{"key":"3158_CR32","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1159\/000058044","volume":"65","author":"YK Gupta","year":"2002","unstructured":"Gupta YK, Chaudhary G, Srivastava AK (2002) Protective effect of resveratrol against pentylenetetrazole-induced seizures and its modulation by an adenosinergic system. Pharmacology 65:170\u2013174","journal-title":"Pharmacology"},{"key":"3158_CR33","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.neuropharm.2015.08.046","volume":"104","author":"D Boison","year":"2016","unstructured":"Boison D (2016) Adenosinergic signaling in epilepsy. Neuropharmacology 104:131\u2013139","journal-title":"Neuropharmacology"},{"key":"3158_CR34","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.tips.2016.02.006","volume":"37","author":"PA Borea","year":"2016","unstructured":"Borea PA, Gessi S, Merighi S, Varani K (2016) Adenosine as a multi-signalling guardian angel in human diseases: When, where and how does it exert its protective effects? Trends Pharmacol Sci 37:419\u2013434","journal-title":"Trends Pharmacol Sci"},{"key":"3158_CR35","doi-asserted-by":"publisher","first-page":"7217","DOI":"10.1073\/pnas.0610068104","volume":"104","author":"B Dasgupta","year":"2007","unstructured":"Dasgupta B, Milbrandt J (2007) Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci 104:7217\u20137222","journal-title":"Proc Natl Acad Sci"},{"key":"3158_CR36","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1042\/BJ20070236","volume":"406","author":"S Fr\u00f6jd\u00f6","year":"2007","unstructured":"Fr\u00f6jd\u00f6 S, Cozzone D, Vidal H, Pirola L (2007) Resveratrol is a class IA phosphoinositide 3-kinase inhibitor. Biochem J 406:511\u2013518","journal-title":"Biochem J"},{"key":"3158_CR37","doi-asserted-by":"publisher","first-page":"e9199","DOI":"10.1371\/journal.pone.0009199","volume":"5","author":"HS Ghosh","year":"2010","unstructured":"Ghosh HS, McBurney M, Robbins PD (2010) SIRT1 Negatively regulates the mammalian target of rapamycin. PLoS ONE 5:e9199","journal-title":"PLoS ONE"},{"key":"3158_CR38","doi-asserted-by":"publisher","first-page":"36387","DOI":"10.1074\/jbc.M110.169284","volume":"285","author":"M Liu","year":"2010","unstructured":"Liu M, Wilk SA, Wang A et al (2010) Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR. J Biol Chem 285:36387\u201336394","journal-title":"J Biol Chem"},{"key":"3158_CR39","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1586\/ern.13.48","volume":"13","author":"M Wong","year":"2013","unstructured":"Wong M (2013) A critical review of mTOR inhibitors and epilepsy: from basic science to clinical trials. Expert Rev Neurother 13:657\u2013669","journal-title":"Expert Rev Neurother"},{"key":"3158_CR40","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1007\/s12264-017-0097-2","volume":"33","author":"Z Li","year":"2017","unstructured":"Li Z, You Z, Li M et al (2017) Protective effect of resveratrol on the brain in a rat model of epilepsy. Neurosci Bull 33:273\u2013280","journal-title":"Neurosci Bull"},{"key":"3158_CR41","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.ynstr.2018.02.001","volume":"8","author":"X Lin","year":"2018","unstructured":"Lin X, Itoga CA, Taha S et al (2018) c-Fos mapping of brain regions activated by multi-modal and electric foot shock stress. Neurobiol Stress 8:92\u2013102","journal-title":"Neurobiol Stress"},{"key":"3158_CR42","doi-asserted-by":"publisher","first-page":"3588","DOI":"10.3390\/ijms20143588","volume":"20","author":"Y-C Chuang","year":"2019","unstructured":"Chuang Y-C, Chen S-D, Jou S-B et al (2019) Sirtuin 1 regulates mitochondrial biogenesis and provides an endogenous neuroprotective mechanism against seizure-induced neuronal cell death in the hippocampus following status epilepticus. Int J Mol Sci 20:3588","journal-title":"Int J Mol Sci"},{"key":"3158_CR43","doi-asserted-by":"publisher","first-page":"108","DOI":"10.3390\/brainsci9050108","volume":"9","author":"AM Hussein","year":"2019","unstructured":"Hussein AM, Eldosoky M, El-Shafey M et al (2019) Effects of GLP-1 receptor activation on a pentylenetetrazole\u2014kindling rat model. Brain Sci 9:108","journal-title":"Brain Sci"},{"key":"3158_CR44","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.eplepsyres.2018.03.009","volume":"142","author":"R-F Wang","year":"2018","unstructured":"Wang R-F, Xue G-F, H\u00f6lscher C et al (2018) Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus. Epilepsy Res 142:45\u201352","journal-title":"Epilepsy Res"},{"key":"3158_CR45","unstructured":"Springer C, Nappe TM (2020) Anticonvulsants toxicity. In: StatPearls. StatPearls Publishing, Treasure Island (FL)"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-020-03158-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-020-03158-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-020-03158-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T19:32:03Z","timestamp":1635276723000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-020-03158-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["3158"],"URL":"https:\/\/doi.org\/10.1007\/s11064-020-03158-0","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,27]]},"assertion":[{"value":"8 July 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 October 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}