{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:24:50Z","timestamp":1784640290832,"version":"3.55.0"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1007\/s11064-020-03213-w","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T08:47:56Z","timestamp":1613033276000},"page":"957-963","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["MiR-122-5p suppresses neuropathic pain development by targeting PDK4"],"prefix":"10.1007","volume":"46","author":[{"given":"Lanlan","family":"Wan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4649-8863","authenticated-orcid":false,"given":"Xianlong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"3213_CR1","doi-asserted-by":"publisher","first-page":"17002","DOI":"10.1038\/nrdp.2017.2","volume":"3","author":"L Colloca","year":"2017","unstructured":"Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, Freeman R, Truini A, Attal N, Finnerup NB, Eccleston C, Kalso E, Bennett DL, Dworkin RH, Raja SN (2017) Neuropathic pain. Nat Rev Dis Primers 3:17002. https:\/\/doi.org\/10.1038\/nrdp.2017.2","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"3213_CR2","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.pain.2013.11.013","volume":"155","author":"O van Hecke","year":"2014","unstructured":"van Hecke O, Austin SK, Khan RA, Smith BH, Torrance N (2014) Neuropathic pain in the general population: a systematic review of epidemiological studies. Pain 155(4):654\u2013662. https:\/\/doi.org\/10.1016\/j.pain.2013.11.013","journal-title":"Pain"},{"issue":"1","key":"3213_CR3","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cell.2014.03.008","volume":"157","author":"TR Cech","year":"2014","unstructured":"Cech TR, Steitz JA (2014) The noncoding RNA revolution-trashing old rules to forge new ones. Cell 157(1):77\u201394. https:\/\/doi.org\/10.1016\/j.cell.2014.03.008","journal-title":"Cell"},{"issue":"4","key":"3213_CR4","doi-asserted-by":"publisher","first-page":"5747","DOI":"10.1002\/jcb.27861","volume":"120","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Liu HL, An LJ, Li L, Wei M, Ge DJ, Su Z (2019) miR-124-3p attenuates neuropathic pain induced by chronic sciatic nerve injury in rats via targeting EZH2. J Cell Biochem 120(4):5747\u20135755. https:\/\/doi.org\/10.1002\/jcb.27861","journal-title":"J Cell Biochem"},{"issue":"1","key":"3213_CR5","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3892\/ijmm.2017.3222","volume":"41","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Mou J, Cao L, Zhen S, Huang H, Bao H (2018) MicroRNA-142-3p relieves neuropathic pain by targeting high mobility group box 1. Int J Mol Med 41(1):501\u2013510. https:\/\/doi.org\/10.3892\/ijmm.2017.3222","journal-title":"Int J Mol Med"},{"key":"3213_CR6","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.biopha.2018.08.005","volume":"107","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Su Z, Liu HL, Li L, Wei M, Ge DJ, Zhang ZJ (2018) Effects of miR-26a-5p on neuropathic pain development by targeting MAPK6 in in CCI rat models. Biomed Pharmacotherapy = Biomed Pharmacotherapie 107:644\u2013649. https:\/\/doi.org\/10.1016\/j.biopha.2018.08.005","journal-title":"Biomed Pharmacotherapy = Biomed Pharmacotherapie"},{"issue":"5","key":"3213_CR7","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1080\/15384047.2018.1423925","volume":"19","author":"X Xu","year":"2018","unstructured":"Xu X, Gao F, Wang J, Tao L, Ye J, Ding L, Ji W, Chen X (2018) MiR-122-5p inhibits cell migration and invasion in gastric cancer by down-regulating DUSP4. Cancer Biol Ther 19(5):427\u2013435. https:\/\/doi.org\/10.1080\/15384047.2018.1423925","journal-title":"Cancer Biol Ther"},{"issue":"2","key":"3213_CR8","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s00432-017-2543-y","volume":"144","author":"J Ma","year":"2018","unstructured":"Ma J, Li T, Han X, Yuan H (2018) Knockdown of LncRNA ANRIL suppresses cell proliferation, metastasis, and invasion via regulating miR-122-5p expression in hepatocellular carcinoma. J Cancer Res Clin Oncol 144(2):205\u2013214. https:\/\/doi.org\/10.1007\/s00432-017-2543-y","journal-title":"J Cancer Res Clin Oncol"},{"issue":"4","key":"3213_CR9","doi-asserted-by":"publisher","first-page":"323","DOI":"10.2174\/1567202614666171026114630","volume":"14","author":"J Lin","year":"2017","unstructured":"Lin J, Zheng X (2017) Salvianolate blocks apoptosis during myocardial infarction by down regulating miR-122-5p. Curr Neurovasc Res 14(4):323\u2013329. https:\/\/doi.org\/10.2174\/1567202614666171026114630","journal-title":"Curr Neurovasc Res"},{"issue":"4","key":"3213_CR10","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/exd.13270","volume":"26","author":"M Jiang","year":"2017","unstructured":"Jiang M, Ma W, Gao Y, Jia K, Zhang Y, Liu H, Sun Q (2017) IL-22-induced miR-122-5p promotes keratinocyte proliferation by targeting Sprouty2. Exp Dermatol 26(4):368\u2013374. https:\/\/doi.org\/10.1111\/exd.13270","journal-title":"Exp Dermatol"},{"key":"3213_CR11","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.omtn.2018.04.005","volume":"11","author":"Y Sun","year":"2018","unstructured":"Sun Y, Wang H, Li Y, Liu S, Chen J, Ying H (2018) miR-24 and miR-122 negatively regulate the transforming growth factor-beta\/Smad signaling pathway in skeletal muscle fibrosis. Mol Ther Nucleic Acids 11:528\u2013537. https:\/\/doi.org\/10.1016\/j.omtn.2018.04.005","journal-title":"Mol Ther Nucleic Acids"},{"issue":"6","key":"3213_CR12","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1053\/j.gastro.2017.01.049","volume":"152","author":"C He","year":"2017","unstructured":"He C, Yu T, Shi Y, Ma C, Yang W, Fang L, Sun M, Wu W, Xiao F, Guo F, Chen M, Yang H, Qian J, Cong Y, Liu Z (2017) MicroRNA 301A promotes intestinal inflammation and colitis-associated Cancer development by inhibiting BTG1. Gastroenterology 152(6):1434\u20131448 e1415. https:\/\/doi.org\/10.1053\/j.gastro.2017.01.049","journal-title":"Gastroenterology"},{"issue":"4","key":"3213_CR13","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1053\/j.gastro.2018.11.059","volume":"156","author":"TS Han","year":"2019","unstructured":"Han TS, Voon DC, Oshima H, Nakayama M, Echizen K, Sakai E, Yong ZWE, Murakami K, Yu L, Minamoto T, Ock CY, Jenkins BJ, Kim SJ, Yang HK, Oshima M (2019) Interleukin 1 up-regulates MicroRNA 135b to promote inflammation-associated gastric carcinogenesis in mice. Gastroenterology 156(4):1140\u20131155 e1144. https:\/\/doi.org\/10.1053\/j.gastro.2018.11.059","journal-title":"Gastroenterology"},{"issue":"6343","key":"3213_CR14","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1126\/science.aam7671","volume":"356","author":"C Peng","year":"2017","unstructured":"Peng C, Li L, Zhang MD, Bengtsson Gonzales C, Parisien M, Belfer I, Usoskin D, Abdo H, Furlan A, Haring M, Lallemend F, Harkany T, Diatchenko L, Hokfelt T, Hjerling-Leffler J, Ernfors P (2017) miR-183 cluster scales mechanical pain sensitivity by regulating basal and neuropathic pain genes. Science 356(6343):1168\u20131171. https:\/\/doi.org\/10.1126\/science.aam7671","journal-title":"Science"},{"issue":"7","key":"3213_CR15","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1038\/bjc.2017.38","volume":"116","author":"D Leclerc","year":"2017","unstructured":"Leclerc D, Pham DN, Levesque N, Truongcao M, Foulkes WD, Sapienza C, Rozen R (2017) Oncogenic role of PDK4 in human colon cancer cells. Br J Cancer 116(7):930\u2013936. https:\/\/doi.org\/10.1038\/bjc.2017.38","journal-title":"Br J Cancer"},{"issue":"9","key":"3213_CR16","first-page":"1725","volume":"8","author":"MR Guda","year":"2018","unstructured":"Guda MR, Asuthkar S, Labak CM, Tsung AJ, Alexandrov I, Mackenzie MJ, Prasad DV, Velpula KK (2018) Targeting PDK4 inhibits breast cancer metabolism. Am J Cancer Res 8(9):1725\u20131738","journal-title":"Am J Cancer Res"},{"key":"3213_CR17","doi-asserted-by":"publisher","first-page":"251","DOI":"10.2147\/CMAR.S185015","volume":"11","author":"J Wang","year":"2019","unstructured":"Wang J, Qian Y, Gao M (2019) Overexpression of PDK4 is associated with cell proliferation, drug resistance and poor prognosis in ovarian cancer. Cancer Manag Res 11:251\u2013262. https:\/\/doi.org\/10.2147\/CMAR.S185015","journal-title":"Cancer Manag Res"},{"issue":"10","key":"3213_CR18","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.2337\/db17-1529","volume":"67","author":"BY Park","year":"2018","unstructured":"Park BY, Jeon JH, Go Y, Ham HJ, Kim JE, Yoo EK, Kwon WH, Jeoung NH, Jeon YH, Koo SH, Kim BG, He L, Park KG, Harris RA, Lee IK (2018) PDK4 deficiency suppresses hepatic glucagon signaling by decreasing cAMP levels. Diabetes 67(10):2054\u20132068. https:\/\/doi.org\/10.2337\/db17-1529","journal-title":"Diabetes"},{"issue":"4","key":"3213_CR19","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.bbrc.2015.12.113","volume":"469","author":"H Park","year":"2016","unstructured":"Park H, Jeoung NH (2016) Inflammation increases pyruvate dehydrogenase kinase 4 (PDK4) expression via the Jun N-terminal kinase (JNK) pathway in C2C12 cells. Biochem Biophys Res Commun 469(4):1049\u20131054. https:\/\/doi.org\/10.1016\/j.bbrc.2015.12.113","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"3213_CR20","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1097\/j.pain.0000000000001122","volume":"159","author":"C Sommer","year":"2018","unstructured":"Sommer C, Leinders M, Uceyler N (2018) Inflammation in the pathophysiology of neuropathic pain. Pain 159(3):595\u2013602. https:\/\/doi.org\/10.1097\/j.pain.0000000000001122","journal-title":"Pain"},{"issue":"9","key":"3213_CR21","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1002\/jnr.23727","volume":"94","author":"MK Jha","year":"2016","unstructured":"Jha MK, Rahman MH, Park DH, Kook H, Lee IK, Lee WH, Suk K (2016) Pyruvate dehydrogenase kinase 2 and 4 gene deficiency attenuates nociceptive behaviors in a mouse model of acute inflammatory pain. J Neurosci Res 94(9):837\u2013849. https:\/\/doi.org\/10.1002\/jnr.23727","journal-title":"J Neurosci Res"},{"issue":"10","key":"3213_CR22","doi-asserted-by":"publisher","first-page":"8555","DOI":"10.1002\/jcb.27096","volume":"119","author":"Y Bao","year":"2018","unstructured":"Bao Y, Wang S, Xie Y, Jin K, Bai Y, Shan S (2018) MiR-28-5p relieves neuropathic pain by targeting Zeb1 in CCI rat models. J Cell Biochem 119(10):8555\u20138563. https:\/\/doi.org\/10.1002\/jcb.27096","journal-title":"J Cell Biochem"},{"issue":"4","key":"3213_CR23","doi-asserted-by":"publisher","first-page":"3815","DOI":"10.1002\/jcp.29276","volume":"235","author":"L Huang","year":"2020","unstructured":"Huang L, Wang L (2020) Upregulation of miR-183 represses neuropathic pain through inhibiton of MAP3K4 in CCI rat models. J Cell Physiol 235(4):3815\u20133822. https:\/\/doi.org\/10.1002\/jcp.29276","journal-title":"J Cell Physiol"},{"issue":"1","key":"3213_CR24","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","volume":"33","author":"GJ Bennett","year":"1988","unstructured":"Bennett GJ, Xie YK (1988) A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33(1):87\u2013107","journal-title":"Pain"},{"issue":"9","key":"3213_CR25","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1373\/clinchem.2016.268953","volume":"63","author":"SA Bustin","year":"2017","unstructured":"Bustin SA, Wittwer CT (2017) MIQE: a step toward more robust and reproducible quantitative PCR. Clin Chem 63(9):1537\u20131538. https:\/\/doi.org\/10.1373\/clinchem.2016.268953","journal-title":"Clin Chem"},{"issue":"11","key":"3213_CR26","doi-asserted-by":"publisher","first-page":"6011","DOI":"10.1074\/jbc.M115.699215","volume":"291","author":"MH Rahman","year":"2016","unstructured":"Rahman MH, Jha MK, Kim JH, Nam Y, Lee MG, Go Y, Harris RA, Park DH, Kook H, Lee IK, Suk K (2016) Pyruvate dehydrogenase kinase-mediated glycolytic metabolic shift in the dorsal root ganglion drives painful diabetic neuropathy. J Biol Chem 291(11):6011\u20136025. https:\/\/doi.org\/10.1074\/jbc.M115.699215","journal-title":"J Biol Chem"},{"key":"3213_CR27","doi-asserted-by":"publisher","unstructured":"Iwasaki H, Sakai A, Maruyama M, Ito T, Sakamoto A, Suzuki H (2019) Increased H19 long non-coding RNA expression in Schwann cells in the peripheral neuropathic pain. J Nippon Med Sch. https:\/\/doi.org\/10.1272\/jnms.JNMS.2018_86-402","DOI":"10.1272\/jnms.JNMS.2018_86-402"},{"key":"3213_CR28","doi-asserted-by":"publisher","unstructured":"Zhong L, Xiao W, Wang F, Liu J, Zhi LJ (2019) miR-21-5p inhibits neuropathic pain development via directly targeting C-C motif ligand 1 and tissue inhibitor of metalloproteinase-3. J Cell Biochem. https:\/\/doi.org\/10.1002\/jcb.28920","DOI":"10.1002\/jcb.28920"},{"issue":"7","key":"3213_CR29","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1007\/s11064-019-02797-2","volume":"44","author":"X Wang","year":"2019","unstructured":"Wang X, Wang H, Zhang T, He M, Liang H, Wang H, Xu L, Chen S, Xu M (2019) Inhibition of MicroRNA-195 alleviates neuropathic pain by targeting Patched1 and inhibiting SHH signaling pathway activation. Neurochem Res 44(7):1690\u20131702. https:\/\/doi.org\/10.1007\/s11064-019-02797-2","journal-title":"Neurochem Res"},{"issue":"3","key":"3213_CR30","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.cell.2011.07.014","volume":"146","author":"L Salmena","year":"2011","unstructured":"Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP (2011) A ceRNA hypothesis: the Rosetta stone of a hidden RNA language? Cell 146(3):353\u2013358. https:\/\/doi.org\/10.1016\/j.cell.2011.07.014","journal-title":"Cell"},{"issue":"2","key":"3213_CR31","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.cell.2011.09.041","volume":"147","author":"P Sumazin","year":"2011","unstructured":"Sumazin P, Yang X, Chiu HS, Chung WJ, Iyer A, Llobet-Navas D, Rajbhandari P, Bansal M, Guarnieri P, Silva J, Califano A (2011) An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma. Cell 147(2):370\u2013381. https:\/\/doi.org\/10.1016\/j.cell.2011.09.041","journal-title":"Cell"},{"issue":"7483","key":"3213_CR32","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1038\/nature12986","volume":"505","author":"Y Tay","year":"2014","unstructured":"Tay Y, Rinn J, Pandolfi PP (2014) The multilayered complexity of ceRNA crosstalk and competition. Nature 505(7483):344\u2013352. https:\/\/doi.org\/10.1038\/nature12986","journal-title":"Nature"},{"issue":"3","key":"3213_CR33","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/kjm2.12025","volume":"35","author":"JC Liu","year":"2019","unstructured":"Liu JC, Xue DF, Wang XQ, Ai DB, Qin PJ (2019) MiR-101 relates to chronic peripheral neuropathic pain through targeting KPNB1 and regulating NF-kappaB signaling. Kaohsiung J Med Sci 35(3):139\u2013145. https:\/\/doi.org\/10.1002\/kjm2.12025","journal-title":"Kaohsiung J Med Sci"},{"issue":"1","key":"3213_CR34","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.stem.2012.10.011","volume":"12","author":"K Takubo","year":"2013","unstructured":"Takubo K, Nagamatsu G, Kobayashi CI, Nakamura-Ishizu A, Kobayashi H, Ikeda E, Goda N, Rahimi Y, Johnson RS, Soga T, Hirao A, Suematsu M, Suda T (2013) Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells. Cell Stem Cell 12(1):49\u201361. https:\/\/doi.org\/10.1016\/j.stem.2012.10.011","journal-title":"Cell Stem Cell"},{"key":"3213_CR35","doi-asserted-by":"publisher","first-page":"697521","DOI":"10.1155\/2013\/697521","volume":"2013","author":"ME Ramos-Nino","year":"2013","unstructured":"Ramos-Nino ME (2013) The role of chronic inflammation in obesity-associated cancers. ISRN Oncol 2013:697521. https:\/\/doi.org\/10.1155\/2013\/697521","journal-title":"ISRN Oncol"},{"issue":"6","key":"3213_CR36","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1161\/01.RES.0000259591.97107.6c","volume":"100","author":"E Nisoli","year":"2007","unstructured":"Nisoli E, Clementi E, Carruba MO, Moncada S (2007) Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome? Circ Res 100(6):795\u2013806. https:\/\/doi.org\/10.1161\/01.RES.0000259591.97107.6c","journal-title":"Circ Res"},{"key":"3213_CR37","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s12916-015-0310-y","volume":"13","author":"G Morris","year":"2015","unstructured":"Morris G, Berk M (2015) The many roads to mitochondrial dysfunction in neuroimmune and neuropsychiatric disorders. BMC Med 13:68. https:\/\/doi.org\/10.1186\/s12916-015-0310-y","journal-title":"BMC Med"},{"issue":"1-2","key":"3213_CR38","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.yexcr.2018.10.010","volume":"373","author":"YH Deng","year":"2018","unstructured":"Deng YH, Deng ZH, Hao H, Wu XL, Gao H, Tang SH, Tang H (2018) MicroRNA-23a promotes colorectal cancer cell survival by targeting PDK4. Exp Cell Res 373(1-2):171\u2013179. https:\/\/doi.org\/10.1016\/j.yexcr.2018.10.010","journal-title":"Exp Cell Res"},{"issue":"7","key":"3213_CR39","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1038\/onc.2016.265","volume":"36","author":"G Li","year":"2017","unstructured":"Li G, Li M, Hu J, Lei R, Xiong H, Ji H, Yin H, Wei Q, Hu G (2017) The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis. Oncogene 36(7):989\u2013998. https:\/\/doi.org\/10.1038\/onc.2016.265","journal-title":"Oncogene"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-020-03213-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s11064-020-03213-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-020-03213-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T16:30:10Z","timestamp":1615393810000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s11064-020-03213-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,10]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["3213"],"URL":"https:\/\/doi.org\/10.1007\/s11064-020-03213-w","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,10]]},"assertion":[{"value":"27 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 December 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 December 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"none.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}