{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:25:56Z","timestamp":1792016756590,"version":"4.4.0"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T00:00:00Z","timestamp":1619395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s11064-021-03334-w","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T09:06:37Z","timestamp":1619427997000},"page":"1618-1626","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Epigenetic Modulation in Parkinson\u2019s Disease and Potential Treatment Therapies"],"prefix":"10.1007","volume":"46","author":[{"given":"Aaina Singh","family":"Rathore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hareram","family":"Birla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saumitra Sen","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walia","family":"Zahra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagera","family":"Dilnashin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka Kumari","family":"Keshri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya Pratap","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,26]]},"reference":[{"issue":"6","key":"3334_CR1","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1073\/pnas.0509567103","volume":"103","author":"CW Shults","year":"2006","unstructured":"Shults CW (2006) Lewy bodies. Proc Natl Acad Sci USA 103(6):1661. https:\/\/doi.org\/10.1073\/pnas.0509567103","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"3334_CR2","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1111\/j.1440-1789.2007.00803.x","volume":"27","author":"K Wakabayashi","year":"2007","unstructured":"Wakabayashi K, Tanji K, Mori F, Takahashi H (2007) The Lewy body in Parkinson\u2019s disease: molecules implicated in the formation and degradation of \u03b1-synuclein aggregates. Neuropathology 27(5):494\u2013506. https:\/\/doi.org\/10.1111\/j.1440-1789.2007.00803.x","journal-title":"Neuropathology"},{"key":"3334_CR3","doi-asserted-by":"publisher","unstructured":"Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, Stefansson H, Liu X, Pliner H, Lee JH, Cheng R, Ikram MA, Ioannidis JPA, Hadjigeorgiou GM, Bis JC, Martinez M, Perlmutter JS, Goate A, Marder K, Fiske B, Sutherland M, Xiromerisiou G, Myers RH, Clark LN, Stefansson K, Hardy JA, Heutink P, Chen H, Wood NW, Houlden H, Payami H, Brice A, Scott WK, Gasser T, Bertram L, Eriksson N, Foroud T, Singleton AB, International Parkinson's Disease Genomics Consortium (IPDGC); Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI); 23andMe; GenePD; NeuroGenetics Research Consortium (NGRC); Hussman Institute of Human Genomics (HIHG); Ashkenazi Jewish Dataset Investigator; Cohorts for Health and Aging Research in Genetic Epidemiology (CHARGE); North American Brain Expression Consortium (NABEC); United Kingdom Brain Expression Consortium (UKBEC); Greek Parkinson's Disease Consortium; Alzheimer Genetic Analysis Group (2014) Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson\u2019s disease. Nature Genetics 46(9):989\u2013993. https:\/\/doi.org\/10.1038\/ng.3043","DOI":"10.1038\/ng.3043"},{"key":"3334_CR4","doi-asserted-by":"publisher","first-page":"846824","DOI":"10.1100\/2012\/846824","volume":"2012","author":"P Santiago","year":"2012","unstructured":"Santiago P (2012) Ferrous versus ferric oral iron formulations for the treatment of iron deficiency: a clinical overview. Sci World J 2012:846824. https:\/\/doi.org\/10.1100\/2012\/846824","journal-title":"Sci World J"},{"issue":"4","key":"3334_CR5","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/jhg.2010.13","volume":"55","author":"TH Hamza","year":"2010","unstructured":"Hamza TH, Payami H (2010) The heritability of risk and age at onset of Parkinson\u2019s disease after accounting for known genetic risk factors. J Hum Genet 55(4):241\u2013243. https:\/\/doi.org\/10.1038\/jhg.2010.13","journal-title":"J Hum Genet"},{"issue":"22","key":"3334_CR6","doi-asserted-by":"publisher","first-page":"4996","DOI":"10.1093\/hmg\/dds335","volume":"21","author":"MF Keller","year":"2012","unstructured":"Keller MF, Saad M, Bras J, Bettella F, Nicolaou N, Sim\u00f3n-S\u00e1nchez J, Mittag F, B\u00fcchel F, Sharma M, Gibbs JR, Schulte C, Moskvina V, Durr A, Holmans P, Kilarski LL, Guerreiro R, Hernandez DG, Brice A, Ylikotila P, Stef\u00e1nsson H, Majamaa K, Morris HR, Williams N, Gasser T, Heutink P, Wood NW, Hardy J, Martinez M, Singleton AB, Nalls MA, Consortium ftIPsDG, 2 TWTCCC (2012) Using genome-wide complex trait analysis to quantify \u2018missing heritability\u2019 in Parkinson\u2019s disease. Hum Mol Genet 21(22):4996\u20135009. doi:https:\/\/doi.org\/10.1093\/hmg\/dds335","journal-title":"Hum Mol Genet"},{"issue":"8","key":"3334_CR7","doi-asserted-by":"publisher","first-page":"677","DOI":"10.2165\/00023210-200721080-00005","volume":"21","author":"J Jankovic","year":"2007","unstructured":"Jankovic J, Stacy M (2007) Medical management of levodopa-associated motor complications in patients with Parkinson\u2019s disease. CNS Drugs 21(8):677\u2013692","journal-title":"CNS Drugs"},{"issue":"6","key":"3334_CR8","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/S1474-4422(05)70098-3","volume":"4","author":"A Schrag","year":"2005","unstructured":"Schrag A (2005) Entacapone in the treatment of Parkinson\u2019s disease. Lancet Neurol 4(6):366\u2013370","journal-title":"Lancet Neurol"},{"key":"3334_CR9","doi-asserted-by":"publisher","first-page":"S86","DOI":"10.1016\/S1471-1931(00)00018-5","volume":"23","author":"TN Chase","year":"2000","unstructured":"Chase TN, Oh JD (2000) Striatal dopamine-and glutamate-mediated dysregulation in experimental parkinsonism. Trends Neurosci 23:S86\u2013S91","journal-title":"Trends Neurosci"},{"issue":"4","key":"3334_CR10","doi-asserted-by":"publisher","first-page":"743","DOI":"10.2147\/NDT.S2006","volume":"4","author":"J Jankovic","year":"2008","unstructured":"Jankovic J, Aguilar LG (2008) Current approaches to the treatment of Parkinson\u2019s disease. Neuropsychiatr Dis Treat 4(4):743","journal-title":"Neuropsychiatr Dis Treat"},{"key":"3334_CR11","unstructured":"Fahn S (2000) The spectrum of levodopa-induced dyskinesias. Ann Neurol 47(4 Suppl 1):S2\u2013S9; discussion S9\u2013S11"},{"issue":"10","key":"3334_CR12","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1038\/nbt.1685","volume":"28","author":"A Portela","year":"2010","unstructured":"Portela A, Esteller M (2010) Epigenetic modifications and human disease. Nat Biotechnol 28(10):1057. https:\/\/doi.org\/10.1038\/nbt.1685","journal-title":"Nat Biotechnol"},{"issue":"4","key":"3334_CR13","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s00401-016-1590-9","volume":"132","author":"C Labb\u00e9","year":"2016","unstructured":"Labb\u00e9 C, Lorenzo-Betancor O, Ross OA (2016) Epigenetic regulation in Parkinson\u2019s disease. Acta Neuropathol 132(4):515\u2013530. doi:https:\/\/doi.org\/10.1007\/s00401-016-1590-9","journal-title":"Acta Neuropathol"},{"issue":"10","key":"3334_CR14","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.4161\/epi.25865","volume":"8","author":"E Masliah","year":"2013","unstructured":"Masliah E, Dumaop W, Galasko D, Desplats P (2013) Distinctive patterns of DNA methylation associated with Parkinson disease. Epigenetics 8(10):1030\u20131038. doi:https:\/\/doi.org\/10.4161\/epi.25865","journal-title":"Epigenetics"},{"issue":"4996","key":"3334_CR15","first-page":"e5009","volume":"21","author":"M Keller","year":"2012","unstructured":"Keller M, Saad M, Bras J, Bettella F, Nicolaou N, Sim\u00f3n-S\u00e1nchez J, Mittag F, Buchel F, Sharma M, Gibbs J, International Parkinson\u2019s Disease Genomics Consortium (IPDGC) Wellcome Trust Case Control Consortium 2 (WTCCC2) (2012) Using genome-wide complex trait analysis to quantify \u2018missing heritability\u2019 in Parkinson\u2019s disease. Hum Mol Genet 21(4996):e5009","journal-title":"Hum Mol Genet"},{"issue":"10","key":"3334_CR16","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1373\/clinchem.2009.125021","volume":"55","author":"R Obeid","year":"2009","unstructured":"Obeid R, Schadt A, Dillmann U, Kostopoulos P, Fassbender K, Herrmann W (2009) Methylation status and neurodegenerative markers in Parkinson disease. Clin Chem 55(10):1852\u20131860. https:\/\/doi.org\/10.1373\/clinchem.2009.125021","journal-title":"Clin Chem"},{"key":"3334_CR17","doi-asserted-by":"publisher","unstructured":"Fern\u00e1ndez-Santiago R, Carballo-Carbajal I, Castellano G, Torrent R, Richaud Y, S\u00e1nchez-Dan\u00e9s A, Vilarrasa-Blasi R, S\u00e1nchez-Pla A, Mosquera JL, Soriano J, L\u00f3pez-Barneo J, Canals JM, Alberch J, Raya \u00c1, Vila M, Consiglio A, Mart\u00edn-Subero JI, Ezquerra M, Tolosa E (2015) Aberrant epigenome in iPSC-derived dopaminergic neurons from Parkinson\u2019s disease patients. EMBO Mol Med 7(12):1529\u20131546. https:\/\/doi.org\/10.15252\/emmm.201505439","DOI":"10.15252\/emmm.201505439"},{"issue":"18","key":"3334_CR18","doi-asserted-by":"publisher","first-page":"6355","DOI":"10.1523\/JNEUROSCI.6119-09.2010","volume":"30","author":"A Jowaed","year":"2010","unstructured":"Jowaed A, Schmitt I, Kaut O, W\u00fcllner U (2010) Methylation regulates alpha-synuclein expression and is decreased in Parkinson\u2019s disease patients\u2019 brains. The Journal of Neuroscience 30(18):6355\u20136359. https:\/\/doi.org\/10.1523\/JNEUROSCI.6119-09.2010","journal-title":"The Journal of Neuroscience"},{"issue":"11","key":"3334_CR19","doi-asserted-by":"publisher","first-page":"e15522","DOI":"10.1371\/journal.pone.0015522","volume":"5","author":"L Matsumoto","year":"2010","unstructured":"Matsumoto L, Takuma H, Tamaoka A, Kurisaki H, Date H, Tsuji S, Iwata A (2010) CpG demethylation enhances alpha-synuclein expression and affects the pathogenesis of Parkinson\u2019s disease. PLOS ONE 5(11):e15522. https:\/\/doi.org\/10.1371\/journal.pone.0015522","journal-title":"PLOS ONE"},{"issue":"13","key":"3334_CR20","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1002\/mds.26319","volume":"30","author":"I Schmitt","year":"2015","unstructured":"Schmitt I, Kaut O, Khazneh H, deBoni L, Ahmad A, Berg D, Klein C, Fr\u00f6hlich H, W\u00fcllner U (2015) l-Dopa increases \u03b1-synuclein DNA methylation in Parkinson\u2019s disease patients in vivo and in vitro. Mov Disord 30(13):1794\u20131801. doi:https:\/\/doi.org\/10.1002\/mds.26319","journal-title":"Mov Disord"},{"issue":"24","key":"3334_CR21","doi-asserted-by":"publisher","first-page":"6514","DOI":"10.1523\/JNEUROSCI.0683-16.2016","volume":"36","author":"DA Figge","year":"2016","unstructured":"Figge DA, Eskow Jaunarajs KL, Standaert DG (2016) Dynamic DNA methylation regulates levodopa-induced dyskinesia. J Neurosci 36(24):6514\u20136524. https:\/\/doi.org\/10.1523\/JNEUROSCI.0683-16.2016","journal-title":"J Neurosci"},{"issue":"9","key":"3334_CR22","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.molmed.2007.07.003","volume":"13","author":"GG Wang","year":"2007","unstructured":"Wang GG, Allis CD, Chi P (2007) Chromatin remodeling and cancer, part I: covalent histone modifications. Trends Mol Med 13(9):363\u2013372. https:\/\/doi.org\/10.1016\/j.molmed.2007.07.003","journal-title":"Trends Mol Med"},{"issue":"6","key":"3334_CR23","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1101\/gr.5704207","volume":"17","author":"CM Koch","year":"2007","unstructured":"Koch CM, Andrews RM, Flicek P, Dillon SC, Kara\u00f6z U, Clelland GK, Wilcox S, Beare DM, Fowler JC, Couttet PJGr (2007) The landscape of histone modifications across 1% of the human genome in five human cell lines. Genome Res 17(6):691\u2013707. https:\/\/doi.org\/10.1101\/gr.5704207","journal-title":"Genome Res"},{"issue":"11","key":"3334_CR24","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1038\/nsmb1307","volume":"14","author":"JA Latham","year":"2007","unstructured":"Latham JA, Dent SYR (2007) Cross-regulation of histone modifications. Nat Struct Mol Biol 14(11):1017\u20131024. doi:https:\/\/doi.org\/10.1038\/nsmb1307","journal-title":"Nat Struct Mol Biol"},{"issue":"1","key":"3334_CR25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.pharmthera.2013.05.010","volume":"140","author":"IF Harrison","year":"2013","unstructured":"Harrison IF, Dexter DT (2013) Epigenetic targeting of histone deacetylase: therapeutic potential in Parkinson\u2019s disease? Pharmacol Ther 140(1):34\u201352. https:\/\/doi.org\/10.1016\/j.pharmthera.2013.05.010","journal-title":"Pharmacol Ther"},{"key":"3334_CR26","doi-asserted-by":"crossref","unstructured":"Bernstein B, Birney E, Dunham I, Green E, Gunter C, Snyder M,\u00a0The ENCODE Project Consortium (2012) Consortium EP. An integrated encyclopedia of DNA elements in the human genome. Nature 489(7414):57\u201374","DOI":"10.1038\/nature11247"},{"issue":"20","key":"3334_CR27","doi-asserted-by":"publisher","first-page":"3012","DOI":"10.1093\/hmg\/ddl243","volume":"15","author":"E Kontopoulos","year":"2006","unstructured":"Kontopoulos E, Parvin JD, Feany MB (2006) \u03b1-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum Mol Genet 15(20):3012\u20133023. doi:https:\/\/doi.org\/10.1093\/hmg\/ddl243","journal-title":"Hum Mol Genet"},{"issue":"2","key":"3334_CR28","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.celrep.2014.09.023","volume":"9","author":"W Vermunt Marit","year":"2014","unstructured":"Vermunt Marit W, Reinink P, Korving J, de Bruijn E, Creyghton Paul M, Basak O, Geeven G, Toonen Pim W, Lansu N, Meunier C, van Heesch S, Clevers H, de Laat W, Cuppen E, Creyghton Menno P (2014) Large-scale identification of coregulated enhancer networks in the adult human brain. Cell Rep 9(2):767\u2013779. https:\/\/doi.org\/10.1016\/j.celrep.2014.09.023","journal-title":"Cell Rep"},{"issue":"4","key":"3334_CR29","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1093\/hmg\/ddu526","volume":"24","author":"H-K Choi","year":"2014","unstructured":"Choi H-K, Choi Y, Kang H, Lim E-j, Park S-Y, Lee H-S, Park J-M, Moon J, Kim Y-J, Choi I, Joe E-H, Choi K-C, Yoon H-G (2014) PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death. Hum Mol Genet 24(4):1127\u20131141. doi:https:\/\/doi.org\/10.1093\/hmg\/ddu526","journal-title":"Hum Mol Genet"},{"key":"3334_CR30","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.neurobiolaging.2015.10.001","volume":"37","author":"C-J Choong","year":"2016","unstructured":"Choong C-J, Sasaki T, Hayakawa H, Yasuda T, Baba K, Hirata Y, Uesato S, Mochizuki H (2016) A novel histone deacetylase 1 and 2 isoform-specific inhibitor alleviates experimental Parkinson\u2019s disease. Neurobiol Aging 37:103\u2013116. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2015.10.001","journal-title":"Neurobiol Aging"},{"key":"3334_CR31","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.4103\/1673-5374.194803","volume":"11","author":"S Hegarty","year":"2016","unstructured":"Hegarty S, Sullivan A, O\u2019Keeffe G (2016) The epigenome as a therapeutic target for Parkinson\u2019s disease. Neural Regen Res 11:1735\u20131738","journal-title":"Neural Regen Res"},{"issue":"1","key":"3334_CR32","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3892\/or.2016.5236","volume":"37","author":"J-W Wei","year":"2017","unstructured":"Wei J-W, Huang K, Yang C, Kang C-S (2017) Non-coding RNAs as regulators in epigenetics. Oncol Rep 37(1):3\u20139","journal-title":"Oncol Rep"},{"issue":"6","key":"3334_CR33","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.tcb.2011.04.001","volume":"21","author":"O Wapinski","year":"2011","unstructured":"Wapinski O, Chang HY (2011) Long noncoding RNAs and human disease. Trends Cell Biol 21(6):354\u2013361. doi:https:\/\/doi.org\/10.1016\/j.tcb.2011.04.001","journal-title":"Trends Cell Biol"},{"issue":"1","key":"3334_CR34","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/1471-2164-8-74","volume":"8","author":"C Scheele","year":"2007","unstructured":"Scheele C, Petrovic N, Faghihi MA, Lassmann T, Fredriksson K, Rooyackers O, Wahlestedt C, Good L, Timmons JA (2007) The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function. BMC Genomics 8(1):74. https:\/\/doi.org\/10.1186\/1471-2164-8-74","journal-title":"BMC Genomics"},{"issue":"2","key":"3334_CR35","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1128\/MCB.06270-11","volume":"32","author":"NG Gokey","year":"2012","unstructured":"Gokey NG, Srinivasan R, Lopez-Anido C, Krueger C, Svaren J (2012) Developmental regulation of MicroRNA expression in Schwann cells. Mol Cell Biol 32(2):558. https:\/\/doi.org\/10.1128\/MCB.06270-11","journal-title":"Mol Cell Biol"},{"issue":"5842","key":"3334_CR36","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1126\/science.1140481","volume":"317","author":"J Kim","year":"2007","unstructured":"Kim J, Inoue K, Ishii J, Vanti WB, Voronov SV, Murchison E, Hannon G, Abeliovich A (2007) A MicroRNA feedback circuit in midbrain dopamine neurons. Science 317(5842):1220. https:\/\/doi.org\/10.1126\/science.1140481","journal-title":"Science"},{"issue":"8","key":"3334_CR37","doi-asserted-by":"publisher","first-page":"2874","DOI":"10.1073\/pnas.0511153103","volume":"103","author":"C Martinat","year":"2006","unstructured":"Martinat C, Bacci J-J, Leete T, Kim J, Vanti WB, Newman AH, Cha JH, Gether U, Wang H, Abeliovich A (2006) Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Proc Natl Acad Sci USA 103(8):2874. doi:https:\/\/doi.org\/10.1073\/pnas.0511153103","journal-title":"Proc Natl Acad Sci USA"},{"issue":"31","key":"3334_CR38","doi-asserted-by":"publisher","first-page":"13052","DOI":"10.1073\/pnas.0906277106","volume":"106","author":"E Junn","year":"2009","unstructured":"Junn E, Lee K-W, Jeong BS, Chan TW, Im J-Y, Mouradian MM (2009) Repression of \u03b1-synuclein expression and toxicity by microRNA-7. Proc Natl Acad Sci USA 106(31):13052\u201313057. doi:https:\/\/doi.org\/10.1073\/pnas.0906277106","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"3334_CR39","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1002\/jnr.23066","volume":"90","author":"J Rodr\u00edguez-Blanco","year":"2012","unstructured":"Rodr\u00edguez-Blanco J, Mart\u00edn V, Garc\u00eda-Santos G, Herrera F, Casado-Zapico S, Antol\u00edn I, Rodriguez C (2012) Cooperative action of JNK and AKT\/mTOR in 1-methyl-4-phenylpyridinium-induced autophagy of neuronal PC12 cells. J Neurosci 90(9):1850\u20131860. doi:https:\/\/doi.org\/10.1002\/jnr.23066","journal-title":"J Neurosci"},{"issue":"17","key":"3334_CR40","doi-asserted-by":"publisher","first-page":"12726","DOI":"10.1074\/jbc.M109.086827","volume":"285","author":"E Doxakis","year":"2010","unstructured":"Doxakis E (2010) Post-transcriptional regulation of \u03b1-synuclein expression by mir-7 and mir-153. J Biol Chem 285(17):12726\u201312734. https:\/\/doi.org\/10.1074\/jbc.M109.086827","journal-title":"J Biol Chem"},{"issue":"8","key":"3334_CR41","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1523\/JNEUROSCI.3900-15.2016","volume":"36","author":"AD Thome","year":"2016","unstructured":"Thome AD, Harms AS, Volpicelli-Daley LA, Standaert DG (2016) microRNA-155 regulates alpha-synuclein-induced inflammatory responses in models of Parkinson disease. J Neurosci 36(8):2383\u20132390","journal-title":"J Neurosci"},{"issue":"1","key":"3334_CR42","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1111\/j.1471-4159.2008.05417.x","volume":"106 106","author":"AP Nicholas","year":"2008","unstructured":"Nicholas AP, Lubin FD, Hallett PJ, Vattem P, Ravenscroft P, Bezard E, Zhou S, Fox SH, Brotchie JM, Sweatt JD, Standaert DG (2008) Striatal histone modifications in models of levodopa-induced dyskinesia. J Neurochem 106 106(1):486\u2013494. doi:https:\/\/doi.org\/10.1111\/j.1471-4159.2008.05417.x","journal-title":"J Neurochem"},{"issue":"28","key":"3334_CR43","doi-asserted-by":"publisher","first-page":"9441","DOI":"10.1523\/JNEUROSCI.5314-13.2014","volume":"34","author":"D Games","year":"2014","unstructured":"Games D, Valera E, Spencer B, Rockenstein E, Mante M, Adame A, Patrick C, Ubhi K, Nuber S, Sacayon P, Zago W, Seubert P, Barbour R, Schenk D, Masliah E (2014) Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson\u2019s disease-like models. J Neurosci 34(28):9441. https:\/\/doi.org\/10.1523\/JNEUROSCI.5314-13.2014","journal-title":"J Neurosci"},{"key":"3334_CR44","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.neulet.2017.08.029","volume":"658","author":"W Jian","year":"2017","unstructured":"Jian W, Wei X, Chen L, Wang Z, Sun Y, Zhu S, Lou H, Yan S, Li X, Zhou J, Zhang B (2017) Inhibition of HDAC6 increases acetylation of peroxiredoxin1\/2 and ameliorates 6-OHDA induced dopaminergic injury. Neurosci Lett 658:114\u2013120. doi:https:\/\/doi.org\/10.1016\/j.neulet.2017.08.029","journal-title":"Neurosci Lett"},{"key":"3334_CR45","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.taap.2017.10.011","volume":"336","author":"Z Zhang","year":"2017","unstructured":"Zhang Z, Guo Z, Zhan Y, Li H, Wu S (2017) Role of histone acetylation in activation of nuclear factor erythroid 2-related factor 2\/heme oxygenase 1 pathway by manganese chloride. Toxicol Appl Pharmacol 336:94\u2013100. doi:https:\/\/doi.org\/10.1016\/j.taap.2017.10.011","journal-title":"Toxicol Appl Pharmacol"},{"issue":"4","key":"3334_CR46","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1124\/mol.109.062174","volume":"77","author":"C Song","year":"2010","unstructured":"Song C, Kanthasamy A, Anantharam V, Sun F, Kanthasamy AG (2010) Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration. Mol Pharmacol 77(4):621. https:\/\/doi.org\/10.1124\/mol.109.062174","journal-title":"Mol Pharmacol"},{"issue":"4","key":"3334_CR47","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/jnc.13172","volume":"134","author":"Y Feng","year":"2015","unstructured":"Feng Y, Liu T, Dong S-Y, Guo Y-J, Jankovic J, Xu H, Wu Y-C (2015) Rotenone affects p53 transcriptional activity and apoptosis via targeting SIRT1 and H3K9 acetylation in SH-SY5Y cells. J Neurochem 134(4):668\u2013676. doi:https:\/\/doi.org\/10.1111\/jnc.13172","journal-title":"J Neurochem"},{"key":"3334_CR48","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.expneurol.2014.04.024","volume":"257","author":"VP Patel","year":"2014","unstructured":"Patel VP, Chu CT (2014) Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: Implications for Parkinson\u2019s disease. Exp Neurol 257:170\u2013181. doi:https:\/\/doi.org\/10.1016\/j.expneurol.2014.04.024","journal-title":"Exp Neurol"},{"key":"3334_CR49","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.neuroscience.2013.04.037","volume":"246","author":"RS Laurent","year":"2013","unstructured":"Laurent RS, O\u2019Brien LM, Ahmad ST (2013) Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson\u2019s disease. Neuroscience 246:382\u2013390","journal-title":"Neuroscience"},{"issue":"41","key":"3334_CR50","doi-asserted-by":"publisher","first-page":"34246","DOI":"10.1074\/jbc.M112.367540","volume":"287","author":"L Yao","year":"2012","unstructured":"Yao L, Li W, She H, Dou J, Jia L, He Y, Yang Q, Zhu J, C\u00e1piro NL, Walker DI (2012) Activation of transcription factor MEF2D by bis (3)-cognitin protects dopaminergic neurons and ameliorates Parkinsonian motor defects. J Biol Chem 287(41):34246\u201334255","journal-title":"J Biol Chem"},{"key":"3334_CR51","doi-asserted-by":"crossref","unstructured":"Gangisetty O, Murugan S (2016) Epigenetic modifications in neurological diseases: natural products as epigenetic modulators a treatment strategy. In: The benefits of natural products for neurodegenerative diseases. Springer, New York, pp\u00a01\u201325","DOI":"10.1007\/978-3-319-28383-8_1"},{"issue":"5","key":"3334_CR52","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3390\/nu9050455","volume":"9","author":"K Ganesan","year":"2017","unstructured":"Ganesan K, Xu B (2017) A critical review on polyphenols and health benefits of black soybeans. Nutrients 9(5):455","journal-title":"Nutrients"},{"key":"3334_CR53","doi-asserted-by":"publisher","DOI":"10.1201\/9781420063561","volume-title":"Nutrients and epigenetics","author":"S-W Choi","year":"2009","unstructured":"Choi S-W, Friso S (2009) Nutrients and epigenetics. CRC Press, Boca Raton"},{"issue":"9","key":"3334_CR54","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.3390\/genes11091094","volume":"11","author":"I Arora","year":"2020","unstructured":"Arora I, Sharma M, Sun LY, Tollefsbol TO (2020) The epigenetic link between polyphenols, aging and age-related diseases. Genes 11(9):1094","journal-title":"Genes"},{"issue":"6","key":"3334_CR55","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1111\/j.1471-4159.2009.06562.x","volume":"112","author":"J Kim","year":"2010","unstructured":"Kim J, Lee HJ, Lee KW (2010) Naturally occurring phytochemicals for the prevention of Alzheimer\u2019s disease. J Neurochem 112(6):1415\u20131430","journal-title":"J Neurochem"},{"key":"3334_CR56","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3389\/fgene.2019.00079","volume":"10","author":"\u00c1 Carlos-Reyes","year":"2019","unstructured":"Carlos-Reyes \u00c1, L\u00f3pez-Gonz\u00e1lez JS, Meneses-Flores M, Gallardo-Rinc\u00f3n D, Ru\u00edz-Garc\u00eda E, Marchat LA, Astudillo-De La Vega H, Hern\u00e1ndez de la Cruz ON, L\u00f3pez-Camarillo C (2019) Dietary compounds as epigenetic modulating agents in cancer. Front Genet 10:79","journal-title":"Front Genet"},{"issue":"3","key":"3334_CR57","doi-asserted-by":"publisher","first-page":"e91303","DOI":"10.1371\/journal.pone.0091303","volume":"9","author":"X Zhu","year":"2014","unstructured":"Zhu X, Li Q, Chang R, Yang D, Song Z, Guo Q, Huang C (2014) Curcumin alleviates neuropathic pain by inhibiting p300\/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model. PLoS ONE 9(3):e91303","journal-title":"PLoS ONE"},{"issue":"11","key":"3334_CR58","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1093\/carcin\/bgt240","volume":"34","author":"H Ogiwara","year":"2013","unstructured":"Ogiwara H, Ui A, Shiotani B, Zou L, Yasui A, Kohno T (2013) Curcumin suppresses multiple DNA damage response pathways and has potency as a sensitizer to PARP inhibitor. Carcinogenesis 34(11):2486\u20132497","journal-title":"Carcinogenesis"},{"key":"3334_CR59","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.bbr.2014.01.051","volume":"264","author":"JA Machado-Filho","year":"2014","unstructured":"Machado-Filho JA, Correia AO, Montenegro ABA, Nobre MEP, Cerqueira GS, Neves KRT, da Gra\u00e7a Naffah-Mazzacoratti M, Cavalheiro EA, de Castro-Brito GA, de Barros-Viana GS (2014) Caffeine neuroprotective effects on 6-OHDA-lesioned rats are mediated by several factors, including pro-inflammatory cytokines and histone deacetylase inhibitions. Behav Brain Res 264:116\u2013125","journal-title":"Behav Brain Res"},{"issue":"5","key":"3334_CR60","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.ajhg.2016.03.006","volume":"98","author":"A Gagliano Sarah","year":"2016","unstructured":"Gagliano Sarah A, Ptak C, Mak Denise YF, Shamsi M, Oh G, Knight J, Boutros Paul C, Petronis A (2016) Allele-skewed DNA modification in the brain: relevance to a schizophrenia GWAS. Am J Hum Genet 98(5):956\u2013962. https:\/\/doi.org\/10.1016\/j.ajhg.2016.03.006","journal-title":"Am J Hum Genet"},{"key":"3334_CR61","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/JPD-160914","volume":"7","author":"JL Jakubowski","year":"2017","unstructured":"Jakubowski JL, Labrie V (2017) Epigenetic biomarkers for Parkinson\u2019s disease: from diagnostics to therapeutics. J Parkinson Dis 7:1\u201312. https:\/\/doi.org\/10.3233\/JPD-160914","journal-title":"J Parkinson Dis"},{"issue":"28","key":"3334_CR62","doi-asserted-by":"publisher","first-page":"8465","DOI":"10.1021\/bi0341152","volume":"42","author":"J Goers","year":"2003","unstructured":"Goers J, Manning-Bog AB, McCormack AL, Millett IS, Doniach S, Di Monte DA, Uversky VN, Fink AL (2003) Nuclear localization of \u03b1-synuclein and its interaction with histones. Biochemistry 42(28):8465\u20138471","journal-title":"Biochemistry"},{"issue":"6","key":"3334_CR63","doi-asserted-by":"publisher","first-page":"2035","DOI":"10.1523\/JNEUROSCI.5634-10.2011","volume":"31","author":"H Jin","year":"2011","unstructured":"Jin H, Kanthasamy A, Ghosh A, Yang Y, Anantharam V, Kanthasamy AG (2011) \u03b1-Synuclein negatively regulates protein kinase C\u03b4 expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity. J Neurosci 31(6):2035\u20132051","journal-title":"J Neurosci"},{"issue":"4","key":"3334_CR64","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/j.freeradbiomed.2012.05.024","volume":"53","author":"A Siddiqui","year":"2012","unstructured":"Siddiqui A, Chinta SJ, Mallajosyula JK, Rajagopolan S, Hanson I, Rane A, Melov S, Andersen JK (2012) Selective binding of nuclear alpha-synuclein to the PGC1alpha promoter under conditions of oxidative stress may contribute to losses in mitochondrial function: implications for Parkinson\u2019s disease. Free Radic Biol Med 53(4):993\u20131003","journal-title":"Free Radic Biol Med"},{"issue":"31","key":"3334_CR65","doi-asserted-by":"publisher","first-page":"13052","DOI":"10.1073\/pnas.0906277106","volume":"106","author":"E Junn","year":"2009","unstructured":"Junn E, Lee K-W, Jeong BS, Chan TW, Im J-Y, Mouradian MM (2009) Repression of \u03b1-synuclein expression and toxicity by microRNA-7. Proc Natl Acad Sci USA 106(31):13052\u201313057","journal-title":"Proc Natl Acad Sci USA"},{"issue":"15","key":"3334_CR66","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1093\/hmg\/ddr210","volume":"20","author":"E Mi\u00f1ones-Moyano","year":"2011","unstructured":"Mi\u00f1ones-Moyano E, Porta S, Escaram\u00eds G, Rabionet R, Iraola S, Kagerbauer B, Espinosa-Parrilla Y, Ferrer I, Estivill X, Mart\u00ed E (2011) MicroRNA profiling of Parkinson\u2019s disease brains identifies early downregulation of miR-34b\/c which modulate mitochondrial function. Hum Mol Genet 20(15):3067\u20133078","journal-title":"Hum Mol Genet"},{"issue":"7306","key":"3334_CR67","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/nature09191","volume":"466","author":"S Gehrke","year":"2010","unstructured":"Gehrke S, Imai Y, Sokol N, Lu B (2010) Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature 466(7306):637\u2013641","journal-title":"Nature"},{"issue":"11","key":"3334_CR68","doi-asserted-by":"publisher","first-page":"9031","DOI":"10.1074\/jbc.C110.212589","volume":"286","author":"P Desplats","year":"2011","unstructured":"Desplats P, Spencer B, Coffee E, Patel P, Michael S, Patrick C, Adame A, Rockenstein E, Masliah E (2011) \u03b1-Synuclein sequesters Dnmt1 from the nucleus: a novel mechanism for epigenetic alterations in Lewy body diseases. J Biol Chem 286(11):9031\u20139037","journal-title":"J Biol Chem"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-021-03334-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-021-03334-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-021-03334-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T09:35:18Z","timestamp":1623144918000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-021-03334-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,26]]},"references-count":68,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["3334"],"URL":"https:\/\/doi.org\/10.1007\/s11064-021-03334-w","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,26]]},"assertion":[{"value":"31 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 April 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}