{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T20:18:24Z","timestamp":1781295504326,"version":"3.54.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T00:00:00Z","timestamp":1621468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81401868"],"award-info":[{"award-number":["81401868"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502148"],"award-info":[{"award-number":["81502148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Province Medical and Health Science and Technology Development Project","award":["2017WS468"],"award-info":[{"award-number":["2017WS468"]}]},{"name":"Teaching reform and research project of undergraduate education in Clinical Medicine College of Shandong University","award":["LCJY-72"],"award-info":[{"award-number":["LCJY-72"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s11064-021-03352-8","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T10:03:26Z","timestamp":1621505006000},"page":"2143-2153","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Role of TRPV4-P2X7 Pathway in Neuropathic Pain in Rats with Chronic Compression of the Dorsal Root Ganglion"],"prefix":"10.1007","volume":"46","author":[{"given":"Xiaohua","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junting","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinli","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaocan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7600-7159","authenticated-orcid":false,"given":"Liping","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,20]]},"reference":[{"key":"3352_CR1","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1016\/j.pain.2011.06.017","volume":"152","author":"TS Jensen","year":"2011","unstructured":"Jensen TS, Baron R, Haanpaa M, Kalso E, Loeser JD, Rice AS, Treede RD (2011) A new definition of neuropathic pain. Pain 152:2204\u20132205","journal-title":"Pain"},{"key":"3352_CR2","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1007\/s12264-017-0200-8","volume":"34","author":"C Moore","year":"2018","unstructured":"Moore C, Gupta R, Jordt SE, Chen Y, Liedtke WB (2018) Regulation of pain and Itch by TRP channels. Neurosci Bull 34:120\u2013142","journal-title":"Neurosci Bull"},{"key":"3352_CR3","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.pbiomolbio.2009.10.002","volume":"103","author":"W Everaerts","year":"2010","unstructured":"Everaerts W, Nilius B, Owsianik G (2010) The vanilloid transient receptor potential channel TRPV4: from structure to disease. Prog Biophys Mol Biol 103:2\u201317","journal-title":"Prog Biophys Mol Biol"},{"key":"3352_CR4","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1007\/s12035-017-0475-9","volume":"55","author":"R Costa","year":"2018","unstructured":"Costa R, Bicca MA, Manjavachi MN, Segat GC, Dias FC, Fernandes ES, Calixto JB (2018) Kinin receptors sensitize TRPV4 channel and induce mechanical hyperalgesia: relevance to paclitaxel-induced peripheral neuropathy in mice. Mol Neurobiol 55:2150\u20132161","journal-title":"Mol Neurobiol"},{"key":"3352_CR5","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s00424-011-1071-x","volume":"463","author":"S Materazzi","year":"2012","unstructured":"Materazzi S, Fusi C, Benemei S, Pedretti P, Patacchini R, Nilius B, Prenen J, Creminon C, Geppetti P, Nassini R (2012) TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism. Pflugers Arch 463:561\u2013569","journal-title":"Pflugers Arch"},{"key":"3352_CR6","doi-asserted-by":"publisher","first-page":"e4622","DOI":"10.7717\/peerj.4622","volume":"6","author":"A Maqboul","year":"2018","unstructured":"Maqboul A, Elsadek B (2018) Expression profiles of TRPV1, TRPV4, TLR4 and ERK1\/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model. PeerJ 6:e4622","journal-title":"PeerJ"},{"key":"3352_CR7","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.bbr.2009.11.034","volume":"208","author":"XL Ding","year":"2010","unstructured":"Ding XL, Wang YH, Ning LP, Zhang Y, Ge HY, Jiang H, Wang R, Yue SW (2010) Involvement of TRPV4-NO-cGMP-PKG pathways in the development of thermal hyperalgesia following chronic compression of the dorsal root ganglion in rats. Behav Brain Res 208:194\u2013201","journal-title":"Behav Brain Res"},{"key":"3352_CR8","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1179\/1743132813Y.0000000261","volume":"36","author":"L Ning","year":"2014","unstructured":"Ning L, Wang C, Fan X, Ding X, Wang Y, Zhang Y, Wang J, Yue S (2014) Role of colchicine-induced microtubule depolymerization in hyperalgesia via TRPV4 in rats with chronic compression of the dorsal root ganglion. Neurol Res 36:70\u201378","journal-title":"Neurol Res"},{"key":"3352_CR9","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1165\/rcmb.2017-0413OC","volume":"59","author":"M Rahman","year":"2018","unstructured":"Rahman M, Sun R, Mukherjee S, Nilius B, Janssen LJ (2018) TRPV4 stimulation releases ATP via pannexin channels in human pulmonary fibroblasts. Am J Respir Cell Mol Biol 59:87\u201395","journal-title":"Am J Respir Cell Mol Biol"},{"key":"3352_CR10","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1248\/bpb.b18-00361","volume":"41","author":"A Ohsaki","year":"2018","unstructured":"Ohsaki A, Tanuma SI, Tsukimoto M (2018) TRPV4 channel-regulated ATP release contributes to gamma-irradiation-induced production of IL-6 and IL-8 in epidermal keratinocytes. Biol Pharm Bull 41:1620\u20131626","journal-title":"Biol Pharm Bull"},{"issue":"249\u2013261","key":"3352_CR11","first-page":"e212","volume":"138","author":"SJ Bonvini","year":"2016","unstructured":"Bonvini SJ, Birrell MA, Grace MS, Maher SA, Adcock JJ, Wortley MA, Dubuis E, Ching YM, Ford AP, Shala F, Miralpeix M, Tarrason G, Smith JA, Belvisi MG (2016) Transient receptor potential cation channel, subfamily V, member 4 and airway sensory afferent activation: role of adenosine triphosphate. J Allergy Clin Immunol 138(249\u2013261):e212","journal-title":"J Allergy Clin Immunol"},{"key":"3352_CR12","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/0306-3623(85)90001-1","volume":"16","author":"G Burnstock","year":"1985","unstructured":"Burnstock G, Kennedy C (1985) Is there a basis for distinguishing two types of P2-purinoceptor? Gen Pharmacol 16:433\u2013440","journal-title":"Gen Pharmacol"},{"key":"3352_CR13","doi-asserted-by":"publisher","first-page":"G401","DOI":"10.1152\/ajpgi.00454.2007","volume":"294","author":"VL Kolachala","year":"2008","unstructured":"Kolachala VL, Bajaj R, Chalasani M, Sitaraman SV (2008) Purinergic receptors in gastrointestinal inflammation. Am J Physiol Gastrointest Liver Physiol 294:G401-410","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"3352_CR14","first-page":"145","volume":"22","author":"C Kennedy","year":"1985","unstructured":"Kennedy C, Burnstock G (1985) ATP produces vasodilation via P1 purinoceptors and vasoconstriction via P2 purinoceptors in the isolated rabbit central ear artery. Blood Vessels 22:145\u2013155","journal-title":"Blood Vessels"},{"key":"3352_CR15","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/0163-7258(94)00048-4","volume":"64","author":"MP Abbracchio","year":"1994","unstructured":"Abbracchio MP, Burnstock G (1994) Purinoceptors: are there families of P2X and P2Y purinoceptors? Pharmacol Ther 64:445\u2013475","journal-title":"Pharmacol Ther"},{"key":"3352_CR16","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/bs.apha.2015.09.001","volume":"75","author":"G Burnstock","year":"2016","unstructured":"Burnstock G (2016) Purinergic mechanisms and pain. Adv Pharmacol 75:91\u2013137","journal-title":"Adv Pharmacol"},{"key":"3352_CR17","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ejphar.2013.01.078","volume":"716","author":"G Burnstock","year":"2013","unstructured":"Burnstock G (2013) Purinergic mechanisms and pain\u2013an update. Eur J Pharmacol 716:24\u201340","journal-title":"Eur J Pharmacol"},{"key":"3352_CR18","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.brainresbull.2018.12.017","volume":"151","author":"L Zou","year":"2019","unstructured":"Zou L, Gong Y, Liu S, Liang S (2019) Natural compounds acting at P2 receptors alleviate peripheral neuropathy. Brain Res Bull 151:125\u2013131","journal-title":"Brain Res Bull"},{"issue":"710\u2013720","key":"3352_CR19","first-page":"e715","volume":"1","author":"PY Liu","year":"2015","unstructured":"Liu PY, Lee IH, Tan PH, Wang YP, Tsai CF, Lin HC, Lee FY, Lu CL (2015) P2X7 receptor mediates spinal microglia activation of visceral hyperalgesia in a rat model of chronic pancreatitis. Cell Mol Gastroenterol Hepatol 1(710\u2013720):e715","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"3352_CR20","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.neuint.2016.12.006","volume":"103","author":"J Xie","year":"2017","unstructured":"Xie J, Liu S, Wu B, Li G, Rao S, Zou L, Yi Z, Zhang C, Jia T, Zhao S, Schmalzing G, Hausmann R, Nie H, Li G, Liang S (2017) The protective effect of resveratrol in the transmission of neuropathic pain mediated by the P2X7 receptor in the dorsal root ganglia. Neurochem Int 103:24\u201335","journal-title":"Neurochem Int"},{"key":"3352_CR21","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1016\/j.bbi.2010.06.001","volume":"24","author":"YX Chu","year":"2010","unstructured":"Chu YX, Zhang Y, Zhang YQ, Zhao ZQ (2010) Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses. Brain Behav Immun 24:1176\u20131189","journal-title":"Brain Behav Immun"},{"key":"3352_CR22","doi-asserted-by":"publisher","first-page":"14257","DOI":"10.1038\/srep14257","volume":"5","author":"RJ Thoppil","year":"2015","unstructured":"Thoppil RJ, Adapala RK, Cappelli HC, Kondeti V, Dudley AC, Gary Meszaros J, Paruchuri S, Thodeti CK (2015) TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation. Sci Rep 5:14257","journal-title":"Sci Rep"},{"key":"3352_CR23","doi-asserted-by":"publisher","first-page":"e0128242","DOI":"10.1371\/journal.pone.0128242","volume":"10","author":"SM Mueller-Tribbensee","year":"2015","unstructured":"Mueller-Tribbensee SM, Karna M, Khalil M, Neurath MF, Reeh PW, Engel MA (2015) Differential contribution of TRPA1, TRPV4 and TRPM8 to colonic nociception in mice. PLoS ONE 10:e0128242","journal-title":"PLoS ONE"},{"key":"3352_CR24","doi-asserted-by":"publisher","first-page":"19084","DOI":"10.1073\/pnas.1005333107","volume":"107","author":"W Everaerts","year":"2010","unstructured":"Everaerts W, Zhen X, Ghosh D, Vriens J, Gevaert T, Gilbert JP, Hayward NJ, McNamara CR, Xue F, Moran MM, Strassmaier T, Uykal E, Owsianik G, Vennekens R, De Ridder D, Nilius B, Fanger CM, Voets T (2010) Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis. Proc Natl Acad Sci USA 107:19084\u201319089","journal-title":"Proc Natl Acad Sci USA"},{"key":"3352_CR25","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.neuropharm.2017.01.005","volume":"116","author":"N Rodriguez-Alvarez","year":"2017","unstructured":"Rodriguez-Alvarez N, Jimenez-Mateos EM, Engel T, Quinlan S, Reschke CR, Conroy RM, Bhattacharya A, Boylan GB, Henshall DC (2017) Effects of P2X7 receptor antagonists on hypoxia-induced neonatal seizures in mice. Neuropharmacology 116:351\u2013363","journal-title":"Neuropharmacology"},{"key":"3352_CR26","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.ejphar.2015.03.008","volume":"756","author":"K Sakamoto","year":"2015","unstructured":"Sakamoto K, Endo K, Suzuki T, Fujimura K, Kurauchi Y, Mori A, Nakahara T, Ishii K (2015) P2X7 receptor antagonists protect against N-methyl-d-aspartic acid-induced neuronal injury in the rat retina. Eur J Pharmacol 756:52\u201358","journal-title":"Eur J Pharmacol"},{"key":"3352_CR27","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.neulet.2007.12.028","volume":"432","author":"Y Zhang","year":"2008","unstructured":"Zhang Y, Wang YH, Ge HY, Arendt-Nielsen L, Wang R, Yue SW (2008) A transient receptor potential vanilloid 4 contributes to mechanical allodynia following chronic compression of dorsal root ganglion in rats. Neurosci Lett 432:222\u2013227","journal-title":"Neurosci Lett"},{"key":"3352_CR28","doi-asserted-by":"publisher","first-page":"6153215","DOI":"10.1155\/2016\/6153215","volume":"2016","author":"YJ Qu","year":"2016","unstructured":"Qu YJ, Jia L, Zhang X, Wei H, Yue SW (2016) MAPK pathways are involved in neuropathic pain in rats with chronic compression of the dorsal root ganglion. Evid-Based Complement Altern Med 2016:6153215","journal-title":"Evid-Based Complement Altern Med"},{"key":"3352_CR29","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s12565-012-0163-9","volume":"88","author":"K Kobayashi","year":"2013","unstructured":"Kobayashi K, Yamanaka H, Noguchi K (2013) Expression of ATP receptors in the rat dorsal root ganglion and spinal cord. Anat Sci Int 88:10\u201316","journal-title":"Anat Sci Int"},{"key":"3352_CR30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1744-8069-8-9","volume":"8","author":"Y Chen","year":"2012","unstructured":"Chen Y, Li G, Huang LY (2012) P2X7 receptors in satellite glial cells mediate high functional expression of P2X3 receptors in immature dorsal root ganglion neurons. Mol Pain 8:9","journal-title":"Mol Pain"},{"key":"3352_CR31","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0304-3959(98)00067-0","volume":"77","author":"SJ Hu","year":"1998","unstructured":"Hu SJ, Xing JL (1998) An experimental model for chronic compression of dorsal root ganglion produced by intervertebral foramen stenosis in the rat. Pain 77:15\u201323","journal-title":"Pain"},{"key":"3352_CR32","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/S0161-4754(03)00091-5","volume":"26","author":"XJ Song","year":"2003","unstructured":"Song XJ, Xu DS, Vizcarra C, Rupert RL (2003) Onset and recovery of hyperalgesia and hyperexcitability of sensory neurons following intervertebral foramen volume reduction and restoration. J Manipulative Physiol Ther 26:426\u2013436","journal-title":"J Manipulative Physiol Ther"},{"key":"3352_CR33","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1152\/jn.00748.2005","volume":"95","author":"C Ma","year":"2006","unstructured":"Ma C, Greenquist KW, Lamotte RH (2006) Inflammatory mediators enhance the excitability of chronically compressed dorsal root ganglion neurons. J Neurophysiol 95:2098\u20132107","journal-title":"J Neurophysiol"},{"key":"3352_CR34","doi-asserted-by":"publisher","first-page":"407","DOI":"10.4149\/gpb_2019026","volume":"38","author":"J Zhou","year":"2019","unstructured":"Zhou J, Feng D, Zhang X, Xia C, Zhang Z, Kang J, Tan Z, Wu B (2019) Involvement of P2X7 receptors in satellite glial cells of dorsal root ganglia in the BmK I -induced pain model of rats. Gen Physiol Biophys 38:407\u2013416","journal-title":"Gen Physiol Biophys"},{"key":"3352_CR35","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.pain.2005.01.002","volume":"114","author":"IP Chessell","year":"2005","unstructured":"Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, Egerton J, Murfin M, Richardson J, Peck WL, Grahames CB, Casula MA, Yiangou Y, Birch R, Anand P, Buell GN (2005) Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain 114:386\u2013396","journal-title":"Pain"},{"key":"3352_CR36","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1126\/science.aaf8924","volume":"354","author":"RR Ji","year":"2016","unstructured":"Ji RR, Chamessian A, Zhang YQ (2016) Pain regulation by non-neuronal cells and inflammation. Science 354:572\u2013577","journal-title":"Science"},{"key":"3352_CR37","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.neuropharm.2009.06.031","volume":"57","author":"MM Halassa","year":"2009","unstructured":"Halassa MM, Fellin T, Haydon PG (2009) Tripartite synapses: roles for astrocytic purines in the control of synaptic physiology and behavior. Neuropharmacology 57:343\u2013346","journal-title":"Neuropharmacology"},{"key":"3352_CR38","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11302-005-6321-y","volume":"1","author":"S Koizumi","year":"2005","unstructured":"Koizumi S, Fujishita K, Inoue K (2005) Regulation of cell-to-cell communication mediated by astrocytic ATP in the CNS. Purinergic Signalling 1:211\u2013217","journal-title":"Purinergic Signalling"},{"key":"3352_CR39","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1017\/S1740925X10000098","volume":"6","author":"L Jasmin","year":"2010","unstructured":"Jasmin L, Vit JP, Bhargava A, Ohara PT (2010) Can satellite glial cells be therapeutic targets for pain control? Neuron Glia Biol 6:63\u201371","journal-title":"Neuron Glia Biol"},{"key":"3352_CR40","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1152\/physrev.00015.2002","volume":"82","author":"RA North","year":"2002","unstructured":"North RA (2002) Molecular physiology of P2X receptors. Physiol Rev 82:1013\u20131067","journal-title":"Physiol Rev"},{"key":"3352_CR41","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1007\/s11302-012-9310-y","volume":"8","author":"D Lecca","year":"2012","unstructured":"Lecca D, Ceruti S, Fumagalli M, Abbracchio MP (2012) Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death. Purinergic Signalling 8:539\u2013557","journal-title":"Purinergic Signalling"},{"key":"3352_CR42","doi-asserted-by":"publisher","first-page":"9864","DOI":"10.1073\/pnas.0611048104","volume":"104","author":"X Zhang","year":"2007","unstructured":"Zhang X, Chen Y, Wang C, Huang LY (2007) Neuronal somatic ATP release triggers neuron-satellite glial cell communication in dorsal root ganglia. Proc Natl Acad Sci USA 104:9864\u20139869","journal-title":"Proc Natl Acad Sci USA"},{"key":"3352_CR43","doi-asserted-by":"publisher","first-page":"3471","DOI":"10.1113\/jphysiol.2011.207829","volume":"589","author":"H Mihara","year":"2011","unstructured":"Mihara H, Boudaka A, Sugiyama T, Moriyama Y, Tominaga M (2011) Transient receptor potential vanilloid 4 (TRPV4)-dependent calcium influx and ATP release in mouse oesophageal keratinocytes. J Physiol 589:3471\u20133482","journal-title":"J Physiol"},{"key":"3352_CR44","doi-asserted-by":"publisher","first-page":"1900889","DOI":"10.1183\/13993003.00889-2019","volume":"54","author":"RD Turner","year":"2019","unstructured":"Turner RD, Birring SS (2019) Chronic cough: ATP, afferent pathways and hypersensitivity. Eur Respir Jl 54:1900889","journal-title":"Eur Respir Jl"},{"key":"3352_CR45","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1523\/JNEUROSCI.3295-09.2010","volume":"30","author":"AK Clark","year":"2010","unstructured":"Clark AK, Staniland AA, Marchand F, Kaan TK, McMahon SB, Malcangio M (2010) P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide. J Neurosci 30:573\u2013582","journal-title":"J Neurosci"},{"key":"3352_CR46","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11302-016-9537-0","volume":"13","author":"J Li","year":"2017","unstructured":"Li J, Li X, Jiang X, Yang M, Yang R, Burnstock G, Xiang Z, Yuan H (2017) Microvesicles shed from microglia activated by the P2X7-p38 pathway are involved in neuropathic pain induced by spinal nerve ligation in rats. Purinergic Signalling 13:13\u201326","journal-title":"Purinergic Signalling"},{"key":"3352_CR47","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1007\/s10753-019-00995-2","volume":"42","author":"J Zhang","year":"2019","unstructured":"Zhang J, Chu M (2019) Targeting of IL-6-relevant long noncoding RNA profiles in inflammatory and tumorous disease. Inflammation 42:1139\u20131146","journal-title":"Inflammation"},{"key":"3352_CR48","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/1742-2094-10-55","volume":"10","author":"P Dubovy","year":"2013","unstructured":"Dubovy P, Brazda V, Klusakova I, Hradilova-Svizenska I (2013) Bilateral elevation of interleukin-6 protein and mRNA in both lumbar and cervical dorsal root ganglia following unilateral chronic compression injury of the sciatic nerve. J Neuroinflammation 10:55","journal-title":"J Neuroinflammation"},{"key":"3352_CR49","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1002\/glia.22628","volume":"62","author":"CH Shieh","year":"2014","unstructured":"Shieh CH, Heinrich A, Serchov T, van Calker D, Biber K (2014) P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-alpha in cultured mouse microglia. Glia 62:592\u2013607","journal-title":"Glia"},{"key":"3352_CR50","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.immuni.2017.06.020","volume":"47","author":"F Di Virgilio","year":"2017","unstructured":"Di Virgilio F, Dal Ben D, Sarti AC, Giuliani AL, Falzoni S (2017) The P2X7 receptor in infection and inflammation. Immunity 47:15\u201331","journal-title":"Immunity"},{"key":"3352_CR51","doi-asserted-by":"publisher","first-page":"e0229475","DOI":"10.1371\/journal.pone.0229475","volume":"15","author":"Y Rabah","year":"2020","unstructured":"Rabah Y, Rubino B, Moukarzel E, Agulhon C (2020) Characterization of transgenic mouse lines for selectively targeting satellite glial cells and macrophages in dorsal root ganglia. PLoS ONE 15:e0229475","journal-title":"PLoS ONE"},{"key":"3352_CR52","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.bbi.2020.04.030","volume":"88","author":"X Hu","year":"2020","unstructured":"Hu X, Liu Y, Wu J, Liu Y, Liu W, Chen J, Yang F (2020) Inhibition of P2X7R in the amygdala ameliorates symptoms of neuropathic pain after spared nerve injury in rats. Brain Behav Immun 88:507\u2013514","journal-title":"Brain Behav Immun"},{"key":"3352_CR53","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.neures.2017.11.006","volume":"134","author":"J Shi","year":"2018","unstructured":"Shi J, Jiang K, Li Z (2018) MiR-145 ameliorates neuropathic pain via inhibiting inflammatory responses and mTOR signaling pathway by targeting Akt3 in a rat model. Neurosci Res 134:10\u201317","journal-title":"Neurosci Res"},{"key":"3352_CR54","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/5584_2017_59","volume":"1051","author":"R Sluyter","year":"2017","unstructured":"Sluyter R (2017) The P2X7 Receptor. Adv Exp Med Biol 1051:17\u201353","journal-title":"Adv Exp Med Biol"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-021-03352-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-021-03352-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-021-03352-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T10:28:57Z","timestamp":1675333737000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-021-03352-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,20]]},"references-count":54,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["3352"],"URL":"https:\/\/doi.org\/10.1007\/s11064-021-03352-8","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,20]]},"assertion":[{"value":"3 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 April 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Experiments were approved by the Institutional Animal Care and Use Committee of Shandong Provincial Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}