{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:45:13Z","timestamp":1770741913946,"version":"3.49.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T00:00:00Z","timestamp":1629158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2018R1A2B6001941"],"award-info":[{"award-number":["NRF-2018R1A2B6001941"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2019R1A6A1A11036849"],"award-info":[{"award-number":["NRF-2019R1A6A1A11036849"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s11064-021-03392-0","type":"journal-article","created":{"date-parts":[[2021,8,17]],"date-time":"2021-08-17T11:03:08Z","timestamp":1629198188000},"page":"3123-3134","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Tat-p27 Ameliorates Neuronal Damage Reducing \u03b1-Synuclein and Inflammatory Responses in Motor Neurons After Spinal Cord Ischemia"],"prefix":"10.1007","volume":"46","author":[{"given":"Woosuk","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Jung","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyo Young","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu Ri","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Myung","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeo Sung","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Koo","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8785-4508","authenticated-orcid":false,"given":"Dae Won","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,17]]},"reference":[{"key":"3392_CR1","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/ane.12343","volume":"131","author":"SR Hanson","year":"2015","unstructured":"Hanson SR, Romi F, Rekand T, Naess H (2015) Long-term outcome after spinal cord infarctions. Acta Neurol Scand 131:253\u2013257","journal-title":"Acta Neurol Scand"},{"key":"3392_CR2","first-page":"191","volume":"57","author":"G Melissano","year":"2016","unstructured":"Melissano G, Bertoglio L, Mascia D et al (2016) Spinal cord ischemia is multifactorial: what is the best protocol? J Cardiovasc Surg (Torino) 57:191\u2013201","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"3392_CR3","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.jare.2020.08.004","volume":"28","author":"A Al Mamun","year":"2020","unstructured":"Al Mamun A, Wu Y, Monalisa I et al (2020) Role of pyroptosis in spinal cord injury and its therapeutic implications. J Adv Res 28:97\u2013109","journal-title":"J Adv Res"},{"key":"3392_CR4","doi-asserted-by":"publisher","first-page":"2012","DOI":"10.1161\/01.STR.28.10.2012","volume":"28","author":"ME Mackey","year":"1997","unstructured":"Mackey ME, Wu Y, Hu R et al (1997) Cell death suggestive of apoptosis after spinal cord ischemia in rabbits. Stroke 28:2012\u20132017","journal-title":"Stroke"},{"key":"3392_CR5","first-page":"3549704","volume":"2020","author":"C Gu","year":"2020","unstructured":"Gu C, Li L, Huang Y et al (2020) Salidroside ameliorates mitochondria-dependent neuronal apoptosis after spinal cord ischemia-reperfusion injury partially through inhibiting oxidative stress and promoting mitophagy. Oxid Med Cell Longev 2020:3549704","journal-title":"Oxid Med Cell Longev"},{"key":"3392_CR6","doi-asserted-by":"publisher","first-page":"26029","DOI":"10.1073\/pnas.1912178116","volume":"116","author":"SK Halder","year":"2019","unstructured":"Halder SK, Milner R (2019) A critical role for microglia in maintaining vascular integrity in the hypoxic spinal cord. Proc Natl Acad Sci USA 116:26029\u201326037","journal-title":"Proc Natl Acad Sci USA"},{"key":"3392_CR7","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1159\/000495466","volume":"26","author":"Y Hua","year":"2019","unstructured":"Hua Y, Xu N, Ma T, Liu Y, Xu H, Lu Y (2019) Anti-inflammatory effect of lycopene on experimental spinal cord ischemia injury via cyclooxygenase-2 suppression. NeuroImmunoModulation 26:84\u201392","journal-title":"NeuroImmunoModulation"},{"key":"3392_CR8","doi-asserted-by":"publisher","first-page":"743","DOI":"10.3390\/antiox9080743","volume":"9","author":"DSA Simpson","year":"2020","unstructured":"Simpson DSA, Oliver PL (2020) ROS generation in microglia: understanding oxidative stress and inflammation in neurodegenerative disease. Antioxidants (Basel) 9:743","journal-title":"Antioxidants (Basel)"},{"key":"3392_CR9","doi-asserted-by":"publisher","first-page":"ra45","DOI":"10.1126\/scisignal.2005965","volume":"8","author":"SG Daniele","year":"2015","unstructured":"Daniele SG, B\u00e9raud D, Davenport C, Cheng K, Yin H, Maguire-Zeiss KA (2015) Activation of MyD88-dependent TLR1\/2 signaling by misfolded \u03b1-synuclein, a protein linked to neurodegenerative disorders. Sci Signal 8:ra45","journal-title":"Sci Signal"},{"key":"3392_CR10","doi-asserted-by":"publisher","first-page":"14","DOI":"10.14802\/jmd.15059","volume":"9","author":"JS Lee","year":"2016","unstructured":"Lee JS, Lee SJ (2016) Mechanism of anti-\u03b1-synuclein immunotherapy. J Mov Disord 9:14\u201319","journal-title":"J Mov Disord"},{"key":"3392_CR11","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.redox.2017.11.010","volume":"14","author":"L Hou","year":"2018","unstructured":"Hou L, Bao X, Zang C et al (2018) Integrin CD11b mediates \u03b1-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway. Redox Biol 14:600\u2013608","journal-title":"Redox Biol"},{"key":"3392_CR12","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1101\/gad.8.1.9","volume":"8","author":"K Polyak","year":"1994","unstructured":"Polyak K, Kato JY, Solomon MJ et al (1994) p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev 8:9\u201322","journal-title":"Genes Dev"},{"key":"3392_CR13","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1002\/(SICI)1097-4652(200004)183:1<18::AID-JCP3>3.0.CO;2-S","volume":"183","author":"A Sgambato","year":"2000","unstructured":"Sgambato A, Cittadini A, Faraglia B, Weinstein IB (2000) Multiple functions of p27(Kip1) and its alterations in tumor cells: a review. J Cell Physiol 183:18\u201327","journal-title":"J Cell Physiol"},{"key":"3392_CR14","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/ana.10472","volume":"53","author":"S Di Giovanni","year":"2003","unstructured":"Di Giovanni S, Knoblach SM, Brandoli C, Aden SA, Hoffman EP, Faden AI (2003) Gene profiling in spinal cord injury shows role of cell cycle in neuronal death. Ann Neurol 53:454\u2013468","journal-title":"Ann Neurol"},{"key":"3392_CR15","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.4161\/cc.4.9.1996","volume":"4","author":"I Cernak","year":"2005","unstructured":"Cernak I, Stoica B, Byrnes KR, Di Giovanni S, Faden AI (2005) Role of the cell cycle in the pathobiology of central nervous system trauma. Cell Cycle 4:1286\u20131293","journal-title":"Cell Cycle"},{"key":"3392_CR16","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1007\/s13311-011-0028-2","volume":"8","author":"J Wu","year":"2011","unstructured":"Wu J, Stoica BA, Faden AI (2011) Cell cycle activation and spinal cord injury. Neurotherapeutics 8:221\u2013228","journal-title":"Neurotherapeutics"},{"key":"3392_CR17","doi-asserted-by":"crossref","unstructured":"Takeda M, Kawaguchi M, Kumatoriya T et al (2011) Effects of minocycline on hind-limb motor function and gray and white matter injury after spinal cord ischemia in rats. Spine (Phila Pa 1976) 36:1919\u20131924.","DOI":"10.1097\/BRS.0b013e3181ffda29"},{"key":"3392_CR18","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nm0598-575","volume":"4","author":"V Ophascharoensuk","year":"1998","unstructured":"Ophascharoensuk V, Fero ML, Hughes J, Roberts JM, Shankland SJ (1998) The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury. Nat Med 4:575\u2013580","journal-title":"Nat Med"},{"key":"3392_CR19","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1124\/mol.62.6.1515","volume":"62","author":"YC Huang","year":"2002","unstructured":"Huang YC, Chuang LY, Hung WC (2002) Mechanisms underlying nonsteroidal anti-inflammatory drug-induced p27(Kip1) expression. Mol Pharmacol 62:1515\u20131521","journal-title":"Mol Pharmacol"},{"key":"3392_CR20","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1007\/s00018-006-6194-4","volume":"63","author":"H Akashiba","year":"2006","unstructured":"Akashiba H, Matsuki N, Nishiyama N (2006) p27 small interfering RNA induces cell death through elevating cell cycle activity in cultured cortical neurons: a proof-of-concept study. Cell Mol Life Sci 63:2397\u20132404","journal-title":"Cell Mol Life Sci"},{"key":"3392_CR21","doi-asserted-by":"publisher","first-page":"6043","DOI":"10.1007\/s12035-015-9498-2","volume":"53","author":"MH Chen","year":"2016","unstructured":"Chen MH, Liu YH, Xu H et al (2016) Lentiviral vector-mediated p27kip1 expression facilitates recovery after spinal cord injury. Mol Neurobiol 53:6043\u20136056","journal-title":"Mol Neurobiol"},{"key":"3392_CR22","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1097\/WNR.0b013e3282f16df6","volume":"18","author":"C Ueyama","year":"2007","unstructured":"Ueyama C, Akashiba H, Nakayama K, Nakayama KI, Nishiyama N, Matsuki N (2007) Ablation of p27 enhance kainate-induced seizure and hippocampal degeneration. NeuroReport 18:1781\u20131785","journal-title":"NeuroReport"},{"key":"3392_CR23","doi-asserted-by":"publisher","first-page":"16368","DOI":"10.18632\/oncotarget.24687","volume":"9","author":"E Gallastegui","year":"2018","unstructured":"Gallastegui E, Domuro C, Serratosa J et al (2018) p27Kip1 regulates alpha-synuclein expression. Oncotarget 9:16368\u201316379","journal-title":"Oncotarget"},{"key":"3392_CR24","doi-asserted-by":"publisher","first-page":"3138","DOI":"10.1161\/STROKEAHA.120.028978","volume":"51","author":"B Chelluboina","year":"2020","unstructured":"Chelluboina B, Kim T, Mehta SL, Kim JY, Bathula S, Vemuganti R (2020) Impact of age and sex on \u03b1-syn (\u03b1-synuclein) knockdown-mediated poststroke recovery. Stroke 51:3138\u20133141","journal-title":"Stroke"},{"key":"3392_CR25","doi-asserted-by":"publisher","first-page":"eaat4285","DOI":"10.1126\/scisignal.aat4285","volume":"11","author":"T Kim","year":"2018","unstructured":"Kim T, Mehta SL, Morris-Blanco KC et al (2018) The microRNA miR-7a-5p ameliorates ischemic brain damage by repressing \u03b1-synuclein. Sci Signal 11:eaat4285","journal-title":"Sci Signal"},{"key":"3392_CR26","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1097\/WNR.0000000000000406","volume":"26","author":"H Qiao","year":"2015","unstructured":"Qiao H, Zhang Q, Yuan H et al (2015) Elevated neuronal \u03b1-synuclein promote microglia activation after spinal cord ischemic\/reperfused injury. NeuroReport 26:656\u2013661","journal-title":"NeuroReport"},{"key":"3392_CR27","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1038\/jcbfm.2008.167","volume":"29","author":"M Sakurai","year":"2009","unstructured":"Sakurai M, Kawamura T, Nishimura H, Suzuki H, Tezuka F, Abe K (2009) Induction of Parkinson disease-related proteins in motor neurons after transient spinal cord ischemia in rabbits. J Cereb Blood Flow Metab 29:752\u2013758","journal-title":"J Cereb Blood Flow Metab"},{"key":"3392_CR28","doi-asserted-by":"publisher","first-page":"9496","DOI":"10.3390\/ijms21249496","volume":"21","author":"W Kim","year":"2020","unstructured":"Kim W, Kwon HJ, Jung HY et al (2020) P27 protects neurons from ischemic damage by suppressing oxidative stress and increasing autophagy in the hippocampus. Int J Mol Sci 21:9496","journal-title":"Int J Mol Sci"},{"key":"3392_CR29","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1093\/cvr\/cvs138","volume":"94","author":"F Konecny","year":"2012","unstructured":"Konecny F, Zou J, Husain M, von Harsdorf R (2012) Post-myocardial infarct p27 fusion protein intravenous delivery averts adverse remodelling and improves heart function and survival in rodents. Cardiovasc Res 94:492\u2013500","journal-title":"Cardiovasc Res"},{"key":"3392_CR30","doi-asserted-by":"publisher","first-page":"16924","DOI":"10.1074\/jbc.M113.542795","volume":"289","author":"X Sun","year":"2014","unstructured":"Sun X, Momen A, Wu J et al (2014) p27 protein protects metabolically stressed cardiomyocytes from apoptosis by promoting autophagy. J Biol Chem 289:16924\u201316935","journal-title":"J Biol Chem"},{"key":"3392_CR31","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1002\/aja.1001940306","volume":"194","author":"NR Cashman","year":"1992","unstructured":"Cashman NR, Durham HD, Blusztajn JK et al (1992) Neuroblastoma x spinal cord (NSC) hybrid cell lines resemble developing motor neurons. Dev Dyn 194:209\u2013221","journal-title":"Dev Dyn"},{"key":"3392_CR32","doi-asserted-by":"publisher","first-page":"e3075","DOI":"10.1038\/cddis.2017.473","volume":"8","author":"DY Yoo","year":"2017","unstructured":"Yoo DY, Cho SB, Jung HY et al (2017) Tat-protein disulfide-isomerase A3: a possible candidate for preventing ischemic damage in the spinal cord. Cell Death Dis 8:e3075","journal-title":"Cell Death Dis"},{"key":"3392_CR33","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1046\/j.1471-4159.2000.0741895.x","volume":"74","author":"CJ Eggett","year":"2000","unstructured":"Eggett CJ, Crosier S, Manning P et al (2000) Development and characterisation of a glutamate-sensitive motor neurone cell line. J Neurochem 74:1895\u20131902","journal-title":"J Neurochem"},{"key":"3392_CR34","doi-asserted-by":"publisher","first-page":"321","DOI":"10.4062\/biomolther.2020.154","volume":"29","author":"EJ Yeo","year":"2021","unstructured":"Yeo EJ, Eum WS, Yeo HJ et al (2021) Protective role of transduced Tat-thioredoxin1 (Trx1) against oxidative stress-induced neuronal cell death via ASK1-MAPK signal pathway. Biomol Ther (Seoul) 29:321\u2013330","journal-title":"Biomol Ther (Seoul)"},{"key":"3392_CR35","doi-asserted-by":"publisher","first-page":"7425","DOI":"10.3390\/ijms21197425","volume":"21","author":"HY Jung","year":"2020","unstructured":"Jung HY, Kwon HJ, Kim W et al (2020) Phosphoglycerate mutase 1 prevents neuronal death from ischemic damage by reducing neuroinflammation in the rabbit spinal cord. Int J Mol Sci 21:7425","journal-title":"Int J Mol Sci"},{"key":"3392_CR36","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"S Reagan-Shaw","year":"2008","unstructured":"Reagan-Shaw S, Nihal M, Ahmad N (2008) Dose translation from animal to human studies revisited. FASEB J 22:659\u2013661","journal-title":"FASEB J"},{"key":"3392_CR37","doi-asserted-by":"publisher","first-page":"104477","DOI":"10.1016\/j.neuint.2019.104477","volume":"129","author":"W Kim","year":"2019","unstructured":"Kim W, Kwon HJ, Jung HY et al (2019) Tat-HSP70 protects neurons from oxidative damage in the NSC34 cells and ischemic damage in the ventral horn of rabbit spinal cord. Neurochem Int 129:104477","journal-title":"Neurochem Int"},{"key":"3392_CR38","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1016\/j.neuint.2008.01.011","volume":"52","author":"A Shen","year":"2008","unstructured":"Shen A, Liu Y, Zhao J et al (2008) Temporal-spatial expressions of p27kip1 and its phosphorylation on Serine-10 after acute spinal cord injury in adult rat: Implications for post-traumatic glial proliferation. Neurochem Int 52:1266\u20131275","journal-title":"Neurochem Int"},{"key":"3392_CR39","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.brainres.2006.11.085","volume":"1135","author":"DS Tian","year":"2007","unstructured":"Tian DS, Xie MJ, Yu ZY et al (2007) Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. Brain Res 1135:177\u2013185","journal-title":"Brain Res"},{"key":"3392_CR40","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.1101\/gad.377106","volume":"20","author":"L Nguyen","year":"2006","unstructured":"Nguyen L, Besson A, Heng JI et al (2006) p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex. Genes Dev 20:1511\u20132124","journal-title":"Genes Dev"},{"key":"3392_CR41","doi-asserted-by":"publisher","first-page":"3754","DOI":"10.1073\/pnas.91.9.3754","volume":"91","author":"W Meikrantz","year":"1994","unstructured":"Meikrantz W, Gisselbrecht S, Tam SW, Schlegel R (1994) Activation of cyclin A-dependent protein kinases during apoptosis. Proc Natl Acad Sci USA 91:3754\u20133758","journal-title":"Proc Natl Acad Sci USA"},{"key":"3392_CR42","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12993-014-0047-3","volume":"11","author":"R Harricharan","year":"2015","unstructured":"Harricharan R, Thaver V, Russell VA, Daniels WM (2015) Tat-induced histopathological alterations mediate hippocampus-associated behavioural impairments in rats. Behav Brain Funct 11:3","journal-title":"Behav Brain Funct"},{"key":"3392_CR43","doi-asserted-by":"publisher","first-page":"11362","DOI":"10.1523\/JNEUROSCI.1208-16.2016","volume":"36","author":"Y Fan","year":"2016","unstructured":"Fan Y, Gao X, Chen J, Liu Y, He JJ (2016) HIV Tat impairs neurogenesis through functioning as a Notch ligand and activation of Notch signaling pathway. J Neurosci 36:11362\u201311373","journal-title":"J Neurosci"},{"key":"3392_CR44","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s11064-018-2678-5","volume":"44","author":"HY Jung","year":"2019","unstructured":"Jung HY, Kwon HJ, Kim W et al (2019) Phosphoglycerate mutase 1 promotes cell proliferation and neuroblast differentiation in the dentate gyrus by facilitating the phosphorylation of cAMP response element-binding protein. Neurochem Res 44:323\u2013332","journal-title":"Neurochem Res"},{"key":"3392_CR45","doi-asserted-by":"publisher","first-page":"S152","DOI":"10.1161\/CIRCULATIONAHA.112.000024","volume":"128","author":"MT Bell","year":"2013","unstructured":"Bell MT, Puskas F, Agoston VA et al (2013) Toll-like receptor 4-dependent microglial activation mediates spinal cord ischemia-reperfusion injury. Circulation 128:S152\u2013S156","journal-title":"Circulation"},{"key":"3392_CR46","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.molmed.2004.10.006","volume":"10","author":"MS Beattie","year":"2004","unstructured":"Beattie MS (2004) Inflammation and apoptosis: linked therapeutic targets in spinal cord injury. Trends Mol Med 10:580\u2013583","journal-title":"Trends Mol Med"},{"key":"3392_CR47","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3389\/fnmol.2017.00224","volume":"10","author":"AA Surguchev","year":"2017","unstructured":"Surguchev AA, Surguchov A (2017) Synucleins and gene expression: Ramblers in a crowd or cops regulating traffic? Front Mol Neurosci 10:224","journal-title":"Front Mol Neurosci"},{"key":"3392_CR48","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.mcn.2014.10.005","volume":"63","author":"I Surgucheva","year":"2014","unstructured":"Surgucheva I, He S, Rich MC et al (2014) Role of synucleins in traumatic brain injury\u2014an experimental in vitro and in vivo study in mice. Mol Cell Neurosci 63:114\u2013123. https:\/\/doi.org\/10.1016\/j.mcn.2014.10.005 (PMID: 25447944)","journal-title":"Mol Cell Neurosci"},{"key":"3392_CR49","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3390\/molecules24020305","volume":"24","author":"AA Surguchev","year":"2019","unstructured":"Surguchev AA, Emamzadeh FN, Surguchov A (2019) Cell responses to extracellular \u03b1-synuclein. Molecules 24:305","journal-title":"Molecules"},{"key":"3392_CR50","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1186\/s12974-020-01940-z","volume":"17","author":"N Li","year":"2020","unstructured":"Li N, Stewart T, Sheng L et al (2020) Immunoregulation of microglial polarization: an unrecognized physiological function of \u03b1-synuclein. J Neuroinflammation 17:272","journal-title":"J Neuroinflammation"},{"key":"3392_CR51","doi-asserted-by":"publisher","first-page":"11720","DOI":"10.1038\/s41598-021-91116-3","volume":"11","author":"AD Sauerbeck","year":"2021","unstructured":"Sauerbeck AD, Goldstein EZ, Alfredo AN, Norenberg M, Marcillo A, McTigue DM (2021) Alpha-synuclein increases in rodent and human spinal cord injury and promotes inflammation and tissue loss. Sci Rep 11:11720","journal-title":"Sci Rep"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-021-03392-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-021-03392-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-021-03392-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T04:24:39Z","timestamp":1634790279000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-021-03392-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,17]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3392"],"URL":"https:\/\/doi.org\/10.1007\/s11064-021-03392-0","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,17]]},"assertion":[{"value":"4 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}