{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T14:52:05Z","timestamp":1769179925798,"version":"3.49.0"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["287614"],"award-info":[{"award-number":["287614"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PAPIIT-UNAM","award":["IA203316"],"award-info":[{"award-number":["IA203316"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s11064-021-03417-8","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T11:02:51Z","timestamp":1628852571000},"page":"3179-3189","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Glutamate, Glutamine, GABA and Oxidative Products in the Pons Following Cortical Injury and Their Role in Motor Functional Recovery"],"prefix":"10.1007","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6006-8275","authenticated-orcid":false,"given":"Laura E.","family":"Ramos-Languren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4542-1883","authenticated-orcid":false,"given":"Alberto","family":"Avila-Luna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1734-6732","authenticated-orcid":false,"given":"Gabriela","family":"Garc\u00eda-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3193-7683","authenticated-orcid":false,"given":"Roberto","family":"Rodr\u00edguez-Labrada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5994-4562","authenticated-orcid":false,"given":"Yaimee","family":"V\u00e1zquez-Mojena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-4271","authenticated-orcid":false,"given":"Carmen","family":"Parra-Cid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0138-0784","authenticated-orcid":false,"given":"Sergio","family":"Montes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0291-4554","authenticated-orcid":false,"given":"Antonio","family":"Bueno-Nava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0323-043X","authenticated-orcid":false,"given":"Rigoberto","family":"Gonz\u00e1lez-Pi\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,13]]},"reference":[{"key":"3417_CR1","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.neulet.2008.07.046","volume":"443","author":"A Bueno-Nava","year":"2008","unstructured":"Bueno-Nava A, Montes S, DelaGarza-Montano P, Alfaro-Rodriguez A, Ortiz A, Gonzalez-Pina R (2008) Reversal of noradrenergic depletion and lipid peroxidation in the pons after brain injury correlates with motor function recovery in rats. Neurosci Lett 443:32\u201336","journal-title":"Neurosci Lett"},{"key":"3417_CR2","doi-asserted-by":"publisher","first-page":"2445","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.04.039","volume":"27","author":"Y Kim","year":"2018","unstructured":"Kim Y, Kim S-H, Kim J-S, Hong BY (2018) Modification of Cerebellar Afferent Pathway in the Subacute Phase of Stroke. J Stroke Cerebrovasc Dis 27:2445\u20132452","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"3417_CR3","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1017\/S1355617715000740","volume":"22","author":"JP Hayes","year":"2016","unstructured":"Hayes JP, Bigler ED, Verfaellie M (2016) Traumatic brain injury as a disorder of brain connectivity. J Int Neuropsychol Soc 22:120\u2013137","journal-title":"J Int Neuropsychol Soc"},{"key":"3417_CR4","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1016\/j.apmr.2019.01.026","volume":"100","author":"Y Kim","year":"2019","unstructured":"Kim Y, Lim SH, Park GY (2019) Crossed cerebellar diaschisis has an adverse effect on functional outcome in the subacute rehabilitation phase of stroke: a case-control study. Arch Phys Med Rehabil 100:1308\u20131316","journal-title":"Arch Phys Med Rehabil"},{"key":"3417_CR5","doi-asserted-by":"publisher","first-page":"2700","DOI":"10.1161\/STROKEAHA.119.025723","volume":"50","author":"JS Kim","year":"2019","unstructured":"Kim JS, Kim S-H, Lim SH, Im S, Hong BY, Oh J, Kim Y (2019) Degeneration of the inferior cerebellar peduncle after middle cerebral artery stroke. Stroke 50:2700\u20132707","journal-title":"Stroke"},{"key":"3417_CR6","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1007\/s11064-006-9196-6","volume":"31","author":"R Gonzalez-Pina","year":"2006","unstructured":"Gonzalez-Pina R, Bueno-Nava A, Montes S, Alfaro-Rodriguez A, Gonzalez-Maciel A, Reynoso-Robles R, Ayala-Guerrero F (2006) Pontine and cerebellar norepinephrine content in adult rats recovering from focal cortical injury. Neurochem Res 31:1443\u20131449","journal-title":"Neurochem Res"},{"issue":"297","key":"3417_CR7","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.bbr.2015.10.009","volume":"1","author":"LE Ramos-Languren","year":"2016","unstructured":"Ramos-Languren LE, Gonz\u00e1lez-Pi\u00f1a R, Montes S, Ch\u00e1vez-Garc\u00eda N, \u00c1vila-Luna A, Bar\u00f3n-Flores V, R\u00edos C (2016) Sensorimotor recovery from cortical injury is accompanied by changes on norepinephrine and serotonin levels in the dentate gyrus and pons. Behav Brain Res 1(297):297\u2013306","journal-title":"Behav Brain Res"},{"key":"3417_CR8","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1007\/s12640-018-9961-8","volume":"35","author":"D Zhang","year":"2019","unstructured":"Zhang D, Xiao M, Wang L, Jia W (2019) Blood-based glutamate scavengers reverse traumatic brain injury-induced synaptic plasticity disruption by decreasing glutamate level in hippocampus interstitial fluid, but not cerebral spinal fluid, in vivo. Neurotox Res 35:360\u2013372","journal-title":"Neurotox Res"},{"key":"3417_CR9","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/0006-8993(84)91437-9","volume":"298","author":"DA Hovda","year":"1984","unstructured":"Hovda DA, Fenney DM (1984) Amphetamine with experience promotes recovery of locomotor function after unilateral frontal cortex injury in the cat. Brain Res 298:358\u2013361","journal-title":"Brain Res"},{"key":"3417_CR10","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12974-019-1396-5","volume":"16","author":"W Liu","year":"2019","unstructured":"Liu W, Li R, Yin J, Guo S, Chen Y, Fan H, Li G, Li Z, Li X, Zhang X, He X, Duan C (2019) Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch. J Neuroinflammation 16:8","journal-title":"J Neuroinflammation"},{"key":"3417_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12975-014-0380-8","volume":"6","author":"H Suzuki","year":"2015","unstructured":"Suzuki H (2015) What is early brain injury? Transl Stroke Res 6:1\u20133","journal-title":"Transl Stroke Res"},{"key":"3417_CR12","doi-asserted-by":"publisher","first-page":"3804","DOI":"10.12659\/MSM.907734","volume":"24","author":"S Yang","year":"2018","unstructured":"Yang S, Chen X, Li S, Sun B, Hang C (2018) Melatonin treatment regulates SIRT3 Expression in early brain injury (EBI) due to Reactive oxygen species (ROS) in a mouse model of Subarachnoid hemorrhage (SAH). Med Sci Monit 24:3804\u20133814","journal-title":"Med Sci Monit"},{"key":"3417_CR13","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/S0028-3908(99)00249-X","volume":"39","author":"LB Goldstein","year":"2000","unstructured":"Goldstein LB (2000) Effects of amphetamines and small related molecules on recovery after stroke in animals and man. Neuropharmacology 39:852\u2013859","journal-title":"Neuropharmacology"},{"key":"3417_CR14","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/0091-3057(90)90279-Q","volume":"35","author":"MG Boyeson","year":"1990","unstructured":"Boyeson MG, Feeney DM (1990) Intraventricular norepinephrine facilitates motor recovery following sensorimotor cortex injury. Pharmacol Biochem Behav 35:497\u2013501","journal-title":"Pharmacol Biochem Behav"},{"key":"3417_CR15","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/0361-9230(92)90080-H","volume":"29","author":"MG Boyeson","year":"1992","unstructured":"Boyeson MG, Krobert KA (1992) Cerebellar norepinephrine infusions facilitate recovery after sensorimotor cortex injury. Brain Res Bull 29:435\u2013439","journal-title":"Brain Res Bull"},{"key":"3417_CR16","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1196\/annals.1418.005","volume":"1144","author":"MP Mattson","year":"2008","unstructured":"Mattson MP (2008) Glutamate and neurotrophic factors in neuronal plasticity and disease. Ann N Y Acad Sci 1144:97\u2013112","journal-title":"Ann N Y Acad Sci"},{"key":"3417_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-015-0545-1","author":"RM Guerriero","year":"2015","unstructured":"Guerriero RM, Giza CC, Rotenberg A (2015) Glutamate and GABA imbalance following traumatic brain injury. Curr Neurol Neurosci Rep. https:\/\/doi.org\/10.1007\/s11910-015-0545-1","journal-title":"Curr Neurol Neurosci Rep"},{"key":"3417_CR18","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/0006-8993(86)90457-9","volume":"362","author":"S Brailowsky","year":"1986","unstructured":"Brailowsky S, Knight RT, Blood K, Scabini D (1986) gamma-Aminobutyric acid-induced potentiation of cortical hemiplegia. Brain Res 362:322\u2013330","journal-title":"Brain Res"},{"key":"3417_CR19","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/S0003-9993(98)90060-0","volume":"79","author":"DI Katz","year":"1998","unstructured":"Katz DI, Alexander MP, Klein RB (1998) Recovery of arm function in patients with paresis after traumatic brain injury. Arch Phys Med Rehabil 79:488\u2013493","journal-title":"Arch Phys Med Rehabil"},{"key":"3417_CR20","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1212\/WNL.52.4.792","volume":"52","author":"K Niimura","year":"1999","unstructured":"Niimura K, Chugani DC, Muzik O, Chugani HT (1999) Cerebellar reorganization following cortical injury in humans: effects of lesion size and age. Neurology 52:792\u2013797","journal-title":"Neurology"},{"key":"3417_CR21","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1152\/jn.00896.2017","volume":"120","author":"AL Yasen","year":"2018","unstructured":"Yasen AL, Smith J, Christie AD (2018) Glutamate and GABA concentrations following mild traumatic brain injury: a pilot study. J Neurophysiol 120:1318\u20131322","journal-title":"J Neurophysiol"},{"key":"3417_CR22","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/S0006-8993(00)02055-2","volume":"861","author":"DM O'Dell","year":"2000","unstructured":"O\u2019Dell DM, Gibson CJ, Wilson MS, DeFord SM, Hamm RJ (2000) Positive and negative modulation of the GABA(A) receptor and outcome after traumatic brain injury in rats. Brain Res 861:325\u2013332","journal-title":"Brain Res"},{"key":"3417_CR23","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1111\/j.1460-9568.2006.05046.x","volume":"24","author":"G Cenni","year":"2006","unstructured":"Cenni G, Blandina P, Mackie K, Nosi D, Formigli L, Giannoni P, Ballini C, Della Corte L, Mannaioni PF, Passani MB (2006) Differential effect of cannabinoid agonists and endocannabinoids on histamine release from distinct regions of the rat brain. Eur J Neurosci 24:1633\u20131644","journal-title":"Eur J Neurosci"},{"key":"3417_CR24","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.brainres.2016.02.006","volume":"1640","author":"TS Anthonymuthu","year":"2016","unstructured":"Anthonymuthu TS, Kenny EM, Bay\u0131r H (2016) Therapies targeting lipid peroxidation in traumatic brain injury. Brain Res 1640:57\u201376","journal-title":"Brain Res"},{"key":"3417_CR25","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1046\/j.1471-4159.1994.62062233.x","volume":"62","author":"KA Krobert","year":"1994","unstructured":"Krobert KA, Sutton RL, Feeney DM (1994) Spontaneous and amphetamine-evoked release of cerebellar noradrenaline after sensorimotor cortex contusion: an in vivo microdialysis study in the awake rat. J Neurochem 62:2233\u20132240","journal-title":"J Neurochem"},{"key":"3417_CR26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1034\/j.1600-0404.2001.00142.x","volume":"103","author":"M Serteser","year":"2001","unstructured":"Serteser M, \u00dazben T, G\u00fcm\u00fcsl\u00fc S, Balkan S, Balkan E (2001) Biochemical evidence of crossed cerebellar diaschisis in terms of nitric oxide indicators and lipid peroxidation products in rats during focal cerebral ischemia. Acta Neurol Scand 103:43\u201348","journal-title":"Acta Neurol Scand"},{"key":"3417_CR27","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1113\/jphysiol.2003.059808","volume":"557","author":"ZJ Daskalakis","year":"2004","unstructured":"Daskalakis ZJ, Paradiso GO, Christensen BK, Fitzgerald PB, Gunraj C, Chen R (2004) Exploring the connectivity between the cerebellum and motor cortex in humans. J Physiol 557:689\u2013700","journal-title":"J Physiol"},{"key":"3417_CR28","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S0361-9230(01)00510-X","volume":"55","author":"KJ Thompson","year":"2001","unstructured":"Thompson KJ, Shoham S, Connor JR (2001) Iron and neurodegenerative disorders. Brain Res Bull 55:155\u2013164","journal-title":"Brain Res Bull"},{"key":"3417_CR29","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1097\/00019052-200412000-00014","volume":"17","author":"R D'Ambrosio","year":"2004","unstructured":"D\u2019Ambrosio R, Perucca E (2004) Epilepsy after head injury. Curr Opin Neurol 17:731\u2013735","journal-title":"Curr Opin Neurol"},{"key":"3417_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bss0610001","volume":"61","author":"KJA Davies","year":"1995","unstructured":"Davies KJA (1995) Oxidative stress: the paradox of aerobic life. Biochem Soc Symp 61:1\u201331","journal-title":"Biochem Soc Symp"},{"key":"3417_CR31","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1096\/fasebj.1.5.2824268","volume":"1","author":"B Halliwell","year":"1987","unstructured":"Halliwell B (1987) Oxidants and human disease: some new concepts. FASEB J 1:358\u2013364","journal-title":"FASEB J"},{"key":"3417_CR32","doi-asserted-by":"publisher","first-page":"1459","DOI":"10.1271\/bbb.59.1459","volume":"59","author":"T Murakami","year":"1995","unstructured":"Murakami T, Takemori K, Yoshizumi H (1995) Prediction of stroke lesions in stroke-prone spontaneously hypertensive rats by glutathione peroxidase in erythrocytes. Biosci Biotechnol Biochem 59:1459\u20131463","journal-title":"Biosci Biotechnol Biochem"},{"key":"3417_CR33","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1042\/cs0930401","volume":"93","author":"G Biagini","year":"1997","unstructured":"Biagini G, Zoli M, Torri C, Boschi S, Vantaggiato G, Ballestri M, Baraldi A, Agnati LF (1997) Protective effects of delapril, indapamide and their combination chronically administered to stroke-prone spontaneously hypertensive rats fed a high-sodium diet. Clin Sci (Lond) 93:401\u2013411","journal-title":"Clin Sci (Lond)"},{"key":"3417_CR34","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.brainresbull.2006.10.005","volume":"71","author":"S Tejada","year":"2007","unstructured":"Tejada S, Sureda A, Roca C, Gamund\u00ed A, Esteban S (2007) Antioxidant response and oxidative damage in brain cortex after high dose of pilocarpine. Brain Res Bullet 71:372\u2013375","journal-title":"Brain Res Bullet"},{"key":"3417_CR35","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ejphar.2011.06.035","volume":"668","author":"PSd Santos","year":"2011","unstructured":"Santos PSd, Costa JP, Tom\u00e9 AdR, Saldanha GB, de Souza GF, Feng D, de Freitas RM (2011) Oxidative stress in rat striatum after pilocarpine-induced seizures is diminished by alpha-tocopherol. Eur J Pharmacol 668:65\u201371","journal-title":"Eur J Pharmacol"},{"key":"3417_CR36","doi-asserted-by":"publisher","first-page":"e1105","DOI":"10.1371\/journal.pone.0001105","volume":"2","author":"PF Fabene","year":"2007","unstructured":"Fabene PF, Merigo F, Benati D, Farace P, Nicolato E, Marzola P, Sbarbati A (2007) Pilocarpine-induced status epilepticus in rats involves ischemic and excitotoxic mechanisms. PloS One 2:e1105","journal-title":"PloS One"},{"key":"3417_CR37","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1097\/NEN.0b013e318181b8ae","volume":"67","author":"G Biagini","year":"2008","unstructured":"Biagini G, Baldelli E, Longo D, Contri MB, Guerrini U, Sironi L, Gelosa P, Zini I, Ragsdale DS, Avoli M (2008) Proepileptic influence of a focal vascular lesion affecting entorhinal cortex-CA3 connections after status epilepticus. J Neuropathol Exp Neurol 67:687\u2013701","journal-title":"J Neuropathol Exp Neurol"},{"key":"3417_CR38","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1161\/01.STR.17.5.817","volume":"17","author":"DM Feeney","year":"1986","unstructured":"Feeney DM, Baron JC (1986) Diaschisis. Stroke 17:817\u2013830","journal-title":"Stroke"},{"key":"3417_CR39","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.nurx.2006.07.010","volume":"3","author":"LB Goldstein","year":"2006","unstructured":"Goldstein LB (2006) Neurotransmitters and motor activity: effects on functional recovery after brain injury. NeuroRx 3:451\u2013457","journal-title":"NeuroRx"},{"key":"3417_CR40","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1016\/S0024-3205(02)02405-0","volume":"72","author":"DS Maharaj","year":"2003","unstructured":"Maharaj DS, Limson JL, Daya S (2003) 6-Hydroxymelatonin converts Fe (III) to Fe (II) and reduces iron-induced lipid peroxidation. Life Sci 72:1367\u20131375","journal-title":"Life Sci"},{"key":"3417_CR41","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1046\/j.1471-4159.1997.69031330.x","volume":"69","author":"B Halliwell","year":"1997","unstructured":"Halliwell B, Gutteridge JMC (1997) Lipid peroxidation in brain homogenates: the role of iron and hydroxyl radicals. J Neurochem 69:1330\u20131330","journal-title":"J Neurochem"},{"key":"3417_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fncel.2021.615372","volume":"15","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Lu X, Tai B, Li W, Li T (2021) Ferroptosis and its multifaceted roles in cerebral stroke. Front Cell Neurosci 15:1\u201310","journal-title":"Front Cell Neurosci"},{"key":"3417_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnins.2020.00776","volume":"14","author":"X She","year":"2020","unstructured":"She X, Lan B, Tian H, Tang B (2020) Cross talk between ferroptosis and cerebral ischemia. Front Neurosci 14:1\u20139","journal-title":"Front Neurosci"},{"key":"3417_CR44","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1177\/0023677217738268","volume":"52","author":"MF Festing","year":"2018","unstructured":"Festing MF (2018) On determining sample size in experiments involving laboratory animals. Lab Anim 52:341\u2013350","journal-title":"Lab Anim"},{"key":"3417_CR45","doi-asserted-by":"publisher","first-page":"2122","DOI":"10.1038\/jcbfm.2012.114","volume":"32","author":"JL Harris","year":"2012","unstructured":"Harris JL, Yeh HW, Choi IY, Lee P, Berman NE, Swerdlow RH, Craciunas SC, Brooks WM (2012) Altered neurochemical profile after traumatic brain injury: H-1-MRS biomarkers of pathological mechanisms. J Cereb Blood Flow Metab 32:2122\u20132134","journal-title":"J Cereb Blood Flow Metab"},{"key":"3417_CR46","first-page":"211","volume":"1","author":"E Olfert","year":"1993","unstructured":"Olfert E, Cross B, Mc William A (1993) Guide for the care and use of experimental animals. Can Council Animal Care 1:211","journal-title":"Can Council Animal Care"},{"key":"3417_CR47","unstructured":"NOM-062-ZOO-1999 (2001) Especificaciones t\u00e9cnicas para la producci\u00f3n, cuidado y uso de los animales de laboratorio. In. Diario Oficial de la Federaci\u00f3n."},{"key":"3417_CR48","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/0006-8993(74)90076-6","volume":"66","author":"RD Hall","year":"1974","unstructured":"Hall RD, Lindholm EP (1974) Organization of motor and somatosensory neocortex in the albino rat. Brain Res 66:23\u201338","journal-title":"Brain Res"},{"key":"3417_CR49","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/B978-0-12-547620-1.50010-2","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"G Paxinos","year":"1982","unstructured":"Paxinos G, Watson C (1982) WITHDRAWN: Plates and Figures. In: Paxinos G, Watson C (eds) The Rat Brain in Stereotaxic Coordinates. Academic Press, USA, pp 13\u2013153"},{"key":"3417_CR50","doi-asserted-by":"publisher","first-page":"1538","DOI":"10.1007\/s11064-010-0213-4","volume":"35","author":"A Bueno-Nava","year":"2010","unstructured":"Bueno-Nava A, Gonzalez-Pina R, Alfaro-Rodriguez A, Nekrassov-Protasova V, Durand-Rivera A, Montes S, Ayala-Guerrero F (2010) Recovery of motor deficit, cerebellar serotonin and lipid peroxidation levels in the cortex of injured rats. Neurochem Res 35:1538\u20131545","journal-title":"Neurochem Res"},{"key":"3417_CR51","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1161\/01.STR.26.4.627","volume":"26","author":"JH Garcia","year":"1995","unstructured":"Garcia JH, Wagner S, Liu K-F, Hu X-j (1995) Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Stroke 26:627\u2013635","journal-title":"Stroke"},{"key":"3417_CR52","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1111\/j.1471-4159.1984.tb12699.x","volume":"42","author":"WJ Triggs","year":"1984","unstructured":"Triggs WJ, Willmore LJ (1984) In vivo lipid-peroxidation in rat-brain following intracortical Fe-2+ injection. J Neurochem 42:976\u2013980","journal-title":"J Neurochem"},{"key":"3417_CR53","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/0304-3940(93)90796-N","volume":"159","author":"A Santamar\u00eda","year":"1993","unstructured":"Santamar\u00eda A, R\u00edos C (1993) MK-801, an N-methyl-d-aspartate receptor antagonist, blocks quinolinic acid-induced lipid-peroxidation in rat corpus striatum. Neurosci Lett 159:51\u201354","journal-title":"Neurosci Lett"},{"key":"3417_CR54","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1023\/A:1023279527545","volume":"28","author":"S Montes","year":"2003","unstructured":"Montes S, Alcaraz-Zubeldia M, Muriel P, Rios C (2003) Role of manganese accumulation in increased brain glutamine of the cirrhotic rat. Neurochem Res 28:911\u2013917","journal-title":"Neurochem Res"},{"key":"3417_CR55","doi-asserted-by":"publisher","DOI":"10.1023\/A:1027329405112","author":"R Gonz\u00e1lez-Pi\u00f1a","year":"1997","unstructured":"Gonz\u00e1lez-Pi\u00f1a R, Paz C (1997) Brain monoamine changes in rats after short periods of ozone exposure. Neurochem Res. https:\/\/doi.org\/10.1023\/A:1027329405112","journal-title":"Neurochem Res"},{"key":"3417_CR56","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e03047","author":"SO Ahmad","year":"2019","unstructured":"Ahmad SO, Baun J, Tipton B, Tate Y, Switzer RC (2019) Modification of AgNOR staining to reveal the nucleolus in thick sections specified for stereological and pathological assessments of brain tissue. Heliyon. https:\/\/doi.org\/10.1016\/j.heliyon.2019.e03047","journal-title":"Heliyon"},{"key":"3417_CR57","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.bbrc.2016.10.086","volume":"482","author":"MM Gaschler","year":"2017","unstructured":"Gaschler MM, Stockwell BR (2017) Lipid peroxidation in cell death. Biochem Biophys Res Commun 482:419\u2013425","journal-title":"Biochem Biophys Res Commun"},{"key":"3417_CR58","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.neuropharm.2018.08.005","volume":"145","author":"ED Hall","year":"2019","unstructured":"Hall ED, Wang JA, Miller DM, Cebak JE, Hill RL (2019) Newer pharmacological approaches for antioxidant neuroprotection in traumatic brain injury. Neuropharmacology 145:247\u2013258","journal-title":"Neuropharmacology"},{"key":"3417_CR59","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1007\/s11064-014-1473-1","volume":"40","author":"AB Walls","year":"2015","unstructured":"Walls AB, Waagepetersen HS, Bak LK, Schousboe A, Sonnewald U (2015) The glutamine\u2013glutamate\/GABA cycle: function, regional differences in glutamate and GABA production and effects of interference with GABA metabolism. Neurochem Res 40:402\u2013409","journal-title":"Neurochem Res"},{"key":"3417_CR60","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1097\/MCO.0000000000000134","volume":"18","author":"F Gu","year":"2015","unstructured":"Gu F, Chauhan V, Chauhan A (2015) Glutathione redox imbalance in brain disorders. Curr Opin Clin Nutr Metab Care 18:89\u201395","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"3417_CR61","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/0891-5849(89)90041-5","volume":"6","author":"U Rafalowska","year":"1989","unstructured":"Rafalowska U, Liu G-J, Floyd RA (1989) Peroxidation induced changes in synaptosomal transport of dopamine and \u03b3-aminobutyric acid. Free Radical Biol Med 6:485\u2013492","journal-title":"Free Radical Biol Med"},{"key":"3417_CR62","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/1742-2094-8-67","volume":"8","author":"H Folkersma","year":"2011","unstructured":"Folkersma H, Foster Dingley JC, van Berckel BN, Rozemuller A, Boellaard R, Huisman MC, Lammertsma AA, Vandertop WP, Molthoff CF (2011) Increased cerebral (R)-[11C]PK11195 uptake and glutamate release in a rat model of traumatic brain injury: a longitudinal pilot study. J Neuroinflammation 8:67","journal-title":"J Neuroinflammation"},{"key":"3417_CR63","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1111\/jcmm.12998","volume":"21","author":"AM Amorini","year":"2017","unstructured":"Amorini AM, Lazzarino G, Di Pietro V, Signoretti S, Belli A, Tavazzi B (2017) Severity of experimental traumatic brain injury modulates changes in concentrations of cerebral free amino acids. J Cell Mol Med 21:530\u2013542","journal-title":"J Cell Mol Med"},{"key":"3417_CR64","doi-asserted-by":"publisher","first-page":"971","DOI":"10.3171\/jns.1998.89.6.0971","volume":"89","author":"P Vespa","year":"1998","unstructured":"Vespa P, Prins M, Ronne-Engstrom E, Caron M, Shalmon E, Hovda DA, Martin NA, Becker DP (1998) Increase in extracellular glutamate caused by reduced cerebral perfusion pressure and seizures after human traumatic brain injury: a microdialysis study. J Neurosurg 89:971\u2013982","journal-title":"J Neurosurg"},{"key":"3417_CR65","doi-asserted-by":"publisher","first-page":"564","DOI":"10.3171\/2009.12.JNS09689","volume":"113","author":"R Chamoun","year":"2010","unstructured":"Chamoun R, Suki D, Gopinath SP, Goodman JC, Robertson C (2010) Role of extracellular glutamate measured by cerebral microdialysis in severe traumatic brain injury. J Neurosurg 113:564\u2013570","journal-title":"J Neurosurg"},{"key":"3417_CR66","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1089\/neu.2009.0962","volume":"27","author":"LC Henry","year":"2010","unstructured":"Henry LC, Tremblay S, Boulanger Y, Ellemberg D, Lassonde M (2010) Neurometabolic changes in the acute phase after sports concussions correlate with symptom severity. J Neurotrauma 27:65\u201376","journal-title":"J Neurotrauma"},{"key":"3417_CR67","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1089\/neu.2010.1739","volume":"28","author":"S Xu","year":"2011","unstructured":"Xu S, Zhuo JC, Racz J, Shi D, Roys S, Fiskum G, Gullapalli R (2011) Early microstructural and metabolic changes following controlled cortical impact injury in rat: a magnetic resonance imaging and spectroscopy study. J Neurotrauma 28:2091\u20132102","journal-title":"J Neurotrauma"},{"key":"3417_CR68","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s11064-006-9225-5","volume":"32","author":"A Diaz-Ruiz","year":"2007","unstructured":"Diaz-Ruiz A, Salgado-Ceballos H, Montes S, Maldonado V, Tristan L, Alcaraz-Zubeldia M, R\u00edos C (2007) Acute alterations of glutamate, glutamine, GABA, and other amino acids after spinal cord contusion in rats. Neurochem Res 32:57\u201363","journal-title":"Neurochem Res"},{"key":"3417_CR69","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1006\/mgme.1999.2857","volume":"67","author":"A-S MaI","year":"1999","unstructured":"MaI A-S, Medina M\u00c1 (1999) Glutamine, as a precursor of glutathione, and oxidative stress. Mol Genet Metab 67:100\u2013105","journal-title":"Mol Genet Metab"},{"key":"3417_CR70","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/0006-8993(92)90639-Q","volume":"569","author":"CK Petito","year":"1992","unstructured":"Petito CK, Chung MC, Verkhovsky LM, Cooper AJL (1992) Brain glutamine synthetase increases following cerebral ischemia in the rat. Brain Res 569:275\u2013280","journal-title":"Brain Res"},{"key":"3417_CR71","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1177\/1545968313520411","volume":"28","author":"YK Kim","year":"2014","unstructured":"Kim YK, Yang EJ, Cho K, Lim JY, Paik N-J (2014) Functional recovery after ischemic stroke is associated with reduced GABAergic inhibition in the cerebral cortex: a GABA PET study. Neurorehabil Neural Repair 28:576\u2013583","journal-title":"Neurorehabil Neural Repair"},{"key":"3417_CR72","first-page":"165","volume-title":"Progress in Brain Research","author":"G Aston-Jones","year":"2000","unstructured":"Aston-Jones G, Rajkowski J, Cohen J (2000) Locus coeruleus and regulation of behavioral flexibility and attention. In: Aston-Jones G, Rajkowski J, Cohen J (eds) Progress in Brain Research. Elsevier, Amsterdam, pp 165\u2013182"},{"key":"3417_CR73","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/cne.903360302","volume":"336","author":"YY Lai","year":"1993","unstructured":"Lai YY, Clements JR, Siegel JM (1993) Glutamatergic and cholinergic projections to the pontine inhibitory area identified with horseradish peroxidase retrograde transport and immunohistochemistry. Journal of Comparative Neurology 336:321\u2013330","journal-title":"Journal of Comparative Neurology"},{"key":"3417_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/antiox10010061","volume":"10","author":"PJ Urrutia","year":"2021","unstructured":"Urrutia PJ, B\u00f3rquez DA, N\u00fa\u00f1ez MT (2021) Inflaming the brain with iron. Antioxidants 10:1\u201327","journal-title":"Antioxidants"},{"key":"3417_CR75","doi-asserted-by":"publisher","DOI":"10.1177\/1747493015607509","author":"J Petrova","year":"2016","unstructured":"Petrova J, Manolov V, Vasilev V, Tzatchev K, Marinov B (2016) Ischemic stroke, inflammation, iron overload\u2014Connection to a hepcidin. Int J Stroke. https:\/\/doi.org\/10.1177\/1747493015607509","journal-title":"Int J Stroke"},{"key":"3417_CR76","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00981","author":"M Daglas","year":"2018","unstructured":"Daglas M, Adlard PA (2018) The involvement of iron in traumatic brain injury and neurodegenerative disease. Front Neurosci. https:\/\/doi.org\/10.3389\/fnins.2018.00981","journal-title":"Front Neurosci"},{"key":"3417_CR77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12975-020-00841-w","volume":"12","author":"AA Rahman","year":"2021","unstructured":"Rahman AA, Amruta N, Pinteaux E, Bix GJ (2021) Neurogenesis after stroke: a therapeutic perspective. Transl Stroke Res 12:1\u201314","journal-title":"Transl Stroke Res"},{"key":"3417_CR78","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S1474-4422(09)70061-4","volume":"8","author":"ZG Zhang","year":"2009","unstructured":"Zhang ZG, Chopp M (2009) Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol 8:491\u2013500","journal-title":"Lancet Neurol"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-021-03417-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-021-03417-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-021-03417-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,5]],"date-time":"2023-02-05T21:13:35Z","timestamp":1675631615000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-021-03417-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,13]]},"references-count":78,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3417"],"URL":"https:\/\/doi.org\/10.1007\/s11064-021-03417-8","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,13]]},"assertion":[{"value":"10 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors do so declare that there are no conflicts of interest. The authors have no relevant financial or nonfinancial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Approval was obtained from the Research Committee of the National Rehabilitation Institute LGII (Protocol No. 91\/17). We adhered to the Guide for the Care and Use of Experimental Animals and the local regulation (Mexican regulation NOM-062-ZOO-1999).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}