{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:46:10Z","timestamp":1786981570162,"version":"build-2736575974"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Vice Chancellor for Research of the Semnan University of Medical Sciences","award":["1538"],"award-info":[{"award-number":["1538"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1007\/s11064-021-03432-9","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T13:07:14Z","timestamp":1629810434000},"page":"3301-3313","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Neuroprotective Effects of Chemerin on a Mouse Stroke Model: Behavioral and Molecular Dimensions"],"prefix":"10.1007","volume":"46","author":[{"given":"Azam","family":"Abareshi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahein","family":"Momenabadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas Ali","family":"Vafaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Reza","family":"Bandegi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4269-9978","authenticated-orcid":false,"given":"Abedin","family":"Vakili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"3432_CR1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.neulet.2012.06.075","volume":"524","author":"X Guo","year":"2012","unstructured":"Guo X, Fu Y, Xu Y, Weng S, Liu D, Cui D, Yu S, Liu X, Jiang K, Dong Y (2012) Chronic mild restraint stress rats decreased CMKLR1 expression in distinct brain region. Neurosci Lett 524:25\u201329","journal-title":"Neurosci Lett"},{"key":"3432_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep26830","volume":"6","author":"G Helfer","year":"2016","unstructured":"Helfer G, Ross AW, Thomson LM, Mayer CD, Stoney PN, McCaffery PJ, Morgan PJ (2016) A neuroendocrine role for chemerin in hypothalamic remodelling and photoperiodic control of energy balance. Sci Rep 6:1\u201312","journal-title":"Sci Rep"},{"key":"3432_CR3","doi-asserted-by":"publisher","first-page":"R79","DOI":"10.1530\/JOE-18-0174","volume":"238","author":"G Helfer","year":"2018","unstructured":"Helfer G, Wu Q-F (2018) Chemerin: a multifaceted adipokine involved in metabolic disorders. J Endocrinol 238:R79\u2013R94","journal-title":"J Endocrinol"},{"key":"3432_CR4","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1002\/cne.23451","volume":"522","author":"AL Miranda-Angulo","year":"2014","unstructured":"Miranda-Angulo AL, Byerly MS, Mesa J, Wang H, Blackshaw S (2014) Rax regulates hypothalamic tanycyte differentiation and barrier function in mice. Journal of Comparative Neurology 522:876\u2013899","journal-title":"Journal of Comparative Neurology"},{"key":"3432_CR5","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3233\/JAD-141227","volume":"43","author":"L Peng","year":"2015","unstructured":"Peng L, Yu Y, Liu J, Li S, He H, Cheng N, Ye RD (2015) The chemerin receptor CMKLR1 is a functional receptor for amyloid-\u03b2 peptide. J Alzheimers Dis 43:227\u2013242","journal-title":"J Alzheimers Dis"},{"key":"3432_CR6","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/obr.12009","volume":"14","author":"J Rourke","year":"2013","unstructured":"Rourke J, Dranse H, Sinal C (2013) Towards an integrative approach to understanding the role of chemerin in human health and disease. Obes Rev 14:245\u2013262","journal-title":"Obes Rev"},{"key":"3432_CR7","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.phrs.2015.07.018","volume":"99","author":"DJ Ferland","year":"2015","unstructured":"Ferland DJ, Watts SW (2015) Chemerin: a comprehensive review elucidating the need for cardiovascular research. Pharmacol Res 99:351\u2013361","journal-title":"Pharmacol Res"},{"key":"3432_CR8","doi-asserted-by":"publisher","first-page":"4778","DOI":"10.3390\/ijms20194778","volume":"20","author":"KB Goralski","year":"2019","unstructured":"Goralski KB, Jackson AE, McKeown BT, Sinal CJ (2019) More than an adipokine: the complex roles of chemerin signaling in cancer. Int J Mol Sci 20:4778","journal-title":"Int J Mol Sci"},{"key":"3432_CR9","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1177\/2042018816629894","volume":"7","author":"S \u0130nci","year":"2016","unstructured":"\u0130nci S, Aksan G, Do\u011fan P (2016) Chemerin as an independent predictor of cardiovascular event risk. Ther Adv Endocrinol Metab 7:57\u201368","journal-title":"Ther Adv Endocrinol Metab"},{"key":"3432_CR10","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1210\/en.2009-1098","volume":"151","author":"MC Ernst","year":"2010","unstructured":"Ernst MC, Issa M, Goralski KB, Sinal CJ (2010) Chemerin exacerbates glucose intolerance in mouse models of obesity and diabetes. Endocrinology 151:1998\u20132007","journal-title":"Endocrinology"},{"key":"3432_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/563951","volume":"2015","author":"C Chang","year":"2015","unstructured":"Chang C, Ji Q, Wu B, Yu K, Zeng Q, Xin S, Liu J, Zhou Y (2015) Chemerin15-ameliorated cardiac ischemia-reperfusion injury is associated with the induction of alternatively activated macrophages. Mediat Inflamm 2015:1\u20139","journal-title":"Mediat Inflamm"},{"key":"3432_CR12","doi-asserted-by":"publisher","first-page":"e13962","DOI":"10.14814\/phy2.13962","volume":"6","author":"N Nakamura","year":"2018","unstructured":"Nakamura N, Naruse K, Kobayashi Y, Miyabe M, Saiki T, Enomoto A, Takahashi M, Matsubara T (2018) Chemerin promotes angiogenesis in vivo. Physiol Rep 6:e13962","journal-title":"Physiol Rep"},{"key":"3432_CR13","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.bbi.2018.02.015","volume":"70","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Xu N, Ding Y, Zhang Y, Li Q, Flores J, Haghighiabyaneh M, Doycheva D, Tang J, Zhang JH (2018) Chemerin suppresses neuroinflammation and improves neurological recovery via CaMKK2\/AMPK\/Nrf2 pathway after germinal matrix hemorrhage in neonatal rats. Brain Behav Immun 70:179\u2013193","journal-title":"Brain Behav Immun"},{"key":"3432_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-018-1236-z","volume":"10","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Xu N, Ding Y, Doycheva DM, Zhang Y, Li Q, Flores J, Haghighiabyaneh M, Tang J, Zhang JH (2019) Chemerin reverses neurological impairments and ameliorates neuronal apoptosis through ChemR23\/CAMKK2\/AMPK pathway in neonatal hypoxic\u2013ischemic encephalopathy. Cell Death Dis 10:1\u201315","journal-title":"Cell Death Dis"},{"key":"3432_CR15","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1248\/bpb.b19-00510","volume":"43","author":"Z Lei","year":"2020","unstructured":"Lei Z, Lu Y, Bai X, Jiang Z, Yu Q (2020) Chemerin-9 peptide enhances memory and ameliorates A\u03b2(1\u201342)-induced object memory impairment in mice. Biol Pharm Bull 43:272\u2013283","journal-title":"Biol Pharm Bull"},{"key":"3432_CR16","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s12017-020-08613-3","volume":"22","author":"S Momenabadi","year":"2020","unstructured":"Momenabadi S, Vafaei AA, Bandegi AR, Zahedi-Khorasani M, Mazaheri Z, Vakili A (2020) Oxytocin reduces brain injury and maintains blood\u2013brain barrier integrity after ischemic stroke in mice. NeuroMol Med 22:557\u2013571","journal-title":"NeuroMol Med"},{"key":"3432_CR17","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1007\/s11011-017-0034-0","volume":"32","author":"K Akhoundzadeh","year":"2017","unstructured":"Akhoundzadeh K, Vakili A, Sameni HR, Vafaei AA, Rashidy-Pour A, Safari M, Mohammadkhani R (2017) Effects of the combined treatment of bone marrow stromal cells with mild exercise and thyroid hormone on brain damage and apoptosis in a mouse focal cerebral ischemia model. Metab Brain Dis 32:1267\u20131277","journal-title":"Metab Brain Dis"},{"key":"3432_CR18","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.neuint.2018.02.001","volume":"114","author":"S Behrouzifar","year":"2018","unstructured":"Behrouzifar S, Vakili A, Bandegi AR, Kokhaei P (2018) Neuroprotective nature of adipokine resistin in the early stages of focal cerebral ischemia in a stroke mouse model. Neurochem Int 114:99\u2013107","journal-title":"Neurochem Int"},{"key":"3432_CR19","doi-asserted-by":"publisher","first-page":"4985","DOI":"10.1007\/s11033-019-04949-7","volume":"46","author":"H Rahmati","year":"2019","unstructured":"Rahmati H, Momenabadi S, Vafaei AA, Bandegi AR, Mazaheri Z, Vakili A (2019) Probiotic supplementation attenuates hippocampus injury and spatial learning and memory impairments in a cerebral hypoperfusion mouse model. Mol Biol Rep 46:4985\u20134995","journal-title":"Mol Biol Rep"},{"key":"3432_CR20","first-page":"24","volume":"21","author":"A Vakili","year":"2008","unstructured":"Vakili A, Zahedi-Khorasani M (2008) Effect of aminoguanidine on post-ischemic damage in rodent model of stroke. Pak J Pharm Sci 21:24\u201328","journal-title":"Pak J Pharm Sci"},{"key":"3432_CR21","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1038\/sj.jcbfm.9600097","volume":"25","author":"A Vakili","year":"2005","unstructured":"Vakili A, Kataoka H, Plesnila N (2005) Role of arginine vasopressin V1 and V2 receptors for brain damage after transient focal cerebral ischemia. J Cereb Blood Flow Metab 25:1012\u20131019","journal-title":"J Cereb Blood Flow Metab"},{"key":"3432_CR22","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1007\/s11064-018-2569-9","volume":"43","author":"Y Asadi","year":"2018","unstructured":"Asadi Y, Gorjipour F, Behrouzifar S, Vakili A (2018) Irisin peptide protects brain against ischemic injury through reducing apoptosis and enhancing BDNF in a rodent model of stroke. Neurochem Res 43:1549\u20131560","journal-title":"Neurochem Res"},{"key":"3432_CR23","first-page":"12","volume":"3","author":"T Alizamir","year":"2017","unstructured":"Alizamir T, Akbari M, Mokhtari T, Hassanzadeh G (2017) Associated functional motor recovery induced by intracerebroventricular (ICV) microinjection of Wharton\u2019s jelly mesenchymal stem cells following brain ischemia\/reperfusion injury in rat: Decreased dark neurons and Bax gene expression in the cerebral corte. J Contemp Med Sci 3:12","journal-title":"J Contemp Med Sci"},{"key":"3432_CR24","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1602\/neurorx.1.1.36","volume":"1","author":"YD Cheng","year":"2004","unstructured":"Cheng YD, Al-Khoury L, Zivin JA (2004) Neuroprotection for ischemic stroke: two decades of success and failure. NeuroRx 1:36\u201345","journal-title":"NeuroRx"},{"key":"3432_CR25","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.pneurobio.2017.10.001","volume":"163","author":"X Jiang","year":"2018","unstructured":"Jiang X, Andjelkovic AV, Zhu L, Yang T, Bennett MV, Chen J, Keep RF, Shi Y (2018) Blood-brain barrier dysfunction and recovery after ischemic stroke. Prog Neurobiol 163:144\u2013171","journal-title":"Prog Neurobiol"},{"key":"3432_CR26","doi-asserted-by":"publisher","first-page":"239","DOI":"10.4103\/0972-2327.104323","volume":"15","author":"KS Anand","year":"2012","unstructured":"Anand KS, Dhikav V (2012) Hippocampus in health and disease: an overview. Ann Indian Acad Neurol 15:239","journal-title":"Ann Indian Acad Neurol"},{"key":"3432_CR27","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.nbd.2013.06.014","volume":"59","author":"W Li","year":"2013","unstructured":"Li W, Huang R, Shetty RA, Thangthaeng N, Liu R, Chen Z, Sumien N, Rutledge M, Dillon GH, Yuan F (2013) Transient focal cerebral ischemia induces long-term cognitive function deficit in an experimental ischemic stroke model. Neurobiol Dis 59:18\u201325","journal-title":"Neurobiol Dis"},{"key":"3432_CR28","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1023\/A:1009676112184","volume":"6","author":"M Mattson","year":"2001","unstructured":"Mattson M, Duan W, Pedersen W, Culmsee C (2001) Neurodegenerative disorders and ischemic brain diseases. Apoptosis 6:69\u201381","journal-title":"Apoptosis"},{"key":"3432_CR29","doi-asserted-by":"publisher","first-page":"469","DOI":"10.2147\/CIA.S233909","volume":"15","author":"H Pawluk","year":"2020","unstructured":"Pawluk H, Wo\u017aniak A, Grze\u015bk G, Ko\u0142odziejska R, Kozakiewicz M, Kopkowska E, Grzechowiak E, Kozera G (2020) The role of selected pro-inflammatory cytokines in pathogenesis of ischemic stroke. Clin Interv Aging 15:469","journal-title":"Clin Interv Aging"},{"key":"3432_CR30","first-page":"1","volume":"2","author":"T Liu","year":"2017","unstructured":"Liu T, Zhang L, Joo D, Sun S-C (2017) NF-\u03baB signaling in inflammation. Signal Transduct Target Ther 2:1\u20139","journal-title":"Signal Transduct Target Ther"},{"key":"3432_CR31","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.3390\/ijms19051362","volume":"19","author":"SJ Geiseler","year":"2018","unstructured":"Geiseler SJ, Morland C (2018) The janus face of VEGF in stroke. Int J Mol Sci 19:1362","journal-title":"Int J Mol Sci"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-021-03432-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-021-03432-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-021-03432-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:11:38Z","timestamp":1634775098000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-021-03432-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,24]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["3432"],"URL":"https:\/\/doi.org\/10.1007\/s11064-021-03432-9","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,24]]},"assertion":[{"value":"28 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}