{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:47:38Z","timestamp":1792633658537,"version":"4.5.0"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T00:00:00Z","timestamp":1642550400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1007\/s11064-021-03474-z","type":"journal-article","created":{"date-parts":[[2022,1,19]],"date-time":"2022-01-19T03:04:52Z","timestamp":1642561492000},"page":"656-666","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Long Non-coding RNA Peg13 Alleviates Hypoxic-Ischemic Brain Damage in Neonatal Mice via miR-20a-5p\/XIAP Axis"],"prefix":"10.1007","volume":"47","author":[{"given":"Huan","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijing","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6347-2564","authenticated-orcid":false,"given":"Xiaosan","family":"Bing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,19]]},"reference":[{"key":"3474_CR1","doi-asserted-by":"publisher","first-page":"116444","DOI":"10.1016\/j.lfs.2019.04.070","volume":"254","author":"Y Liu","year":"2020","unstructured":"Liu Y, Wang H, Liu N, Du J, Lan X, Qi X, Zhuang C, Sun T, Li Y, Yu J (2020) Oxymatrine protects neonatal rat against hypoxic-ischemic brain damage via PI3K\/Akt\/GSK3beta pathway. Life Sci 254:116444","journal-title":"Life Sci"},{"key":"3474_CR2","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.4103\/1673-5374.272615","volume":"15","author":"LJ Jiang","year":"2020","unstructured":"Jiang LJ, Xu ZX, Wu MF, Dong GQ, Zhang LL, Gao JY, Feng CX, Feng X (2020) Resatorvid protects against hypoxic-ischemic brain damage in neonatal rats. Neural Regen Res 15:1316\u20131325","journal-title":"Neural Regen Res"},{"key":"3474_CR3","first-page":"929","volume":"35","author":"L Yang","year":"2020","unstructured":"Yang L, Zhao H, Cui H (2020) Treatment and new progress of neonatal hypoxic-ischemic brain damage. Histol Histopathol 35:929\u2013936","journal-title":"Histol Histopathol"},{"key":"3474_CR4","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1002\/jnr.24590","volume":"98","author":"C Disdier","year":"2020","unstructured":"Disdier C, Stonestreet BS (2020) Hypoxic-ischemic-related cerebrovascular changes and potential therapeutic strategies in the neonatal brain. J Neurosci Res 98:1468\u20131484","journal-title":"J Neurosci Res"},{"key":"3474_CR5","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.cca.2015.08.021","volume":"450","author":"H Lv","year":"2015","unstructured":"Lv H, Wang Q, Wu S, Yang L, Ren P, Yang Y, Gao J, Li L (2015) Neonatal hypoxic ischemic encephalopathy-related biomarkers in serum and cerebrospinal fluid. Clin Chim Acta 450:282\u2013297","journal-title":"Clin Chim Acta"},{"key":"3474_CR6","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jpeds.2017.10.060","volume":"194","author":"AN Massaro","year":"2018","unstructured":"Massaro AN, Wu YW, Bammler TK, Comstock B, Mathur A, McKinstry RC, Chang T, Mayock DE, Mulkey SB, Van Meurs K, Juul S (2018) Plasma biomarkers of brain injury in neonatal hypoxic-ischemic encephalopathy. J Pediatr 194:67\u201375","journal-title":"J Pediatr"},{"key":"3474_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-981-10-5203-3_1","volume":"1008","author":"J Jarroux","year":"2017","unstructured":"Jarroux J, Morillon A, Pinskaya M (2017) History, discovery, and classification of lncRNAs. Adv Exp Med Biol 1008:1\u201346","journal-title":"Adv Exp Med Biol"},{"key":"3474_CR8","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.gpb.2016.12.005","volume":"15","author":"IM Dykes","year":"2017","unstructured":"Dykes IM, Emanueli C (2017) Transcriptional and post-transcriptional gene regulation by long non-coding RNA. Genom Proteomics Bioinform 15:177\u2013186","journal-title":"Genom Proteomics Bioinform"},{"key":"3474_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbrc.2020.05.047","volume":"528","author":"H Li","year":"2020","unstructured":"Li H, Xu LX, Yu J, Tan L, Miao P, Yang X, Tian Q, Li M, Feng CX, Yang Y, Sha N, Feng X, Sun B, Gong M, Ding X (2020) The role of a lncRNA (TCONS_00044595) in regulating pineal CLOCK expression after neonatal hypoxia-ischemia brain injury. Biochem Biophys Res Commun 528:1\u20136","journal-title":"Biochem Biophys Res Commun"},{"key":"3474_CR10","doi-asserted-by":"publisher","first-page":"147070","DOI":"10.1016\/j.brainres.2020.147070","volume":"1748","author":"Y Tan","year":"2020","unstructured":"Tan Y, Du RL, Su ZY, Xue LL, Liu J, Zhang BL, Huang SJ, Li LJ, Xi-Yang YB, Xiong LL (2020) Vof-16 knockout improves the recovery from hypoxic-ischemic brain damage of neonatal rats. Brain Res 1748:147070","journal-title":"Brain Res"},{"key":"3474_CR11","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.expneurol.2015.12.014","volume":"277","author":"J Zhang","year":"2016","unstructured":"Zhang J, Yuan L, Zhang X, Hamblin MH, Zhu T, Meng F, Li Y, Chen YE, Yin KJ (2016) Altered long non-coding RNA transcriptomic profiles in brain microvascular endothelium after cerebral ischemia. Exp Neurol 277:162\u2013170","journal-title":"Exp Neurol"},{"key":"3474_CR12","doi-asserted-by":"publisher","first-page":"e0243644","DOI":"10.1371\/journal.pone.0243644","volume":"15","author":"Y Jiang","year":"2020","unstructured":"Jiang Y, Wang Y, Sun Y, Jiang H (2020) Long non-coding RNA Peg13 attenuates the sevoflurane toxicity against neural stem cells by sponging microRNA-128\u20133p to preserve Sox13 expression. PLoS ONE 15:e0243644","journal-title":"PLoS ONE"},{"key":"3474_CR13","first-page":"7968","volume":"12","author":"H Feng","year":"2020","unstructured":"Feng H, Gui Q, Zhu W, Wu G, Dong X, Shen M, Luo H, Xue S, Cheng Q (2020) Long-noncoding RNA Peg13 alleviates epilepsy progression in mice via the miR-490-3p\/Psmd11 axis to inactivate the Wnt\/beta-catenin pathway. Am J Transl Res 12:7968\u20137981","journal-title":"Am J Transl Res"},{"key":"3474_CR14","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1038\/nrg.2016.20","volume":"17","author":"DW Thomson","year":"2016","unstructured":"Thomson DW, Dinger ME (2016) Endogenous microRNA sponges: evidence and controversy. Nat Rev Genet 17:272\u2013283","journal-title":"Nat Rev Genet"},{"key":"3474_CR15","doi-asserted-by":"publisher","first-page":"10573","DOI":"10.1111\/jcmm.15677","volume":"24","author":"Y Feng","year":"2020","unstructured":"Feng Y, Duan C, Luo Z, Xiao W, Tian F (2020) Silencing miR-20a-5p inhibits axonal growth and neuronal branching and prevents epileptogenesis through RGMa-RhoA-mediated synaptic plasticity. J Cell Mol Med 24:10573\u201310588","journal-title":"J Cell Mol Med"},{"key":"3474_CR16","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00381-020-04690-8","volume":"37","author":"M Wang","year":"2021","unstructured":"Wang M, Rong Y, Luo L (2021) Neuroprotective effects of icariin in neonatal hypoxia-ischemic brain damage via its anti-apoptotic property. Childs Nerv Syst 37:39\u201346","journal-title":"Childs Nerv Syst"},{"key":"3474_CR17","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/s12974-020-01932-z","volume":"17","author":"M Jiao","year":"2020","unstructured":"Jiao M, Li X, Chen L, Wang X, Yuan B, Liu T, Dong Q, Mei H, Yin H (2020) Neuroprotective effect of astrocyte-derived IL-33 in neonatal hypoxic-ischemic brain injury. J Neuroinflamm 17:251","journal-title":"J Neuroinflamm"},{"key":"3474_CR18","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.omtn.2020.01.009","volume":"20","author":"J Zhao","year":"2020","unstructured":"Zhao J, He L, Yin L (2020) lncRNA NEAT1 binds to MiR-339-5p to increase HOXA1 and alleviate ischemic brain damage in neonatal mice. Mol Ther Nucleic Acids 20:117\u2013127","journal-title":"Mol Ther Nucleic Acids"},{"key":"3474_CR19","doi-asserted-by":"publisher","first-page":"4723","DOI":"10.12659\/MSM.917213","volume":"25","author":"R Sha","year":"2019","unstructured":"Sha R, Zhang B, Han X, Peng J, Zheng C, Zhang F, Huang X (2019) Electroacupuncture alleviates ischemic brain injury by inhibiting the miR-223\/NLRP3 pathway. Med Sci Monit: Int Med J Exp Clin Res 25:4723\u20134733","journal-title":"Med Sci Monit: Int Med J Exp Clin Res"},{"key":"3474_CR20","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1007\/s12031-021-01872-0","volume":"71","author":"Y Lei","year":"2021","unstructured":"Lei Y, Jin X, Sun M, Ji Z (2021) miR-129-5p ameliorates ischemic brain injury by binding to SIAH1 and activating the mTOR signaling pathway. J Mol Neurosci 71:1761\u20131771","journal-title":"J Mol Neurosci"},{"key":"3474_CR21","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1111\/jcmm.12835","volume":"20","author":"W Fang","year":"2016","unstructured":"Fang W, Guo J, Cao Y, Wang S, Pang C, Li M, Dou L, Man Y, Huang X, Shen T, Li J (2016) MicroRNA-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression. J Cell Mol Med 20:1467\u20131480","journal-title":"J Cell Mol Med"},{"key":"3474_CR22","doi-asserted-by":"publisher","first-page":"104343","DOI":"10.1016\/j.yexmp.2019.104343","volume":"112","author":"Q Yang","year":"2020","unstructured":"Yang Q, Wu MF, Zhu LH, Qiao LX, Zhao RB, Xia ZK (2020) Long non-coding RNA Snhg3 protects against hypoxia\/ischemia-induced neonatal brain injury. Exp Mol Pathol 112:104343","journal-title":"Exp Mol Pathol"},{"key":"3474_CR23","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.modgep.2004.03.008","volume":"4","author":"W Davies","year":"2004","unstructured":"Davies W, Smith RJ, Kelsey G, Wilkinson LS (2004) Expression patterns of the novel imprinted genes Nap1l5 and Peg13 and their non-imprinted host genes in the adult mouse brain. Gene Expr Patterns 4:741\u2013747","journal-title":"Gene Expr Patterns"},{"key":"3474_CR24","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2022172118","author":"M Keshavarz","year":"2021","unstructured":"Keshavarz M, Tautz D (2021) The imprinted lncRNA Peg13 regulates sexual preference and the sex-specific brain transcriptome in mice. Proc Natl Acad Sci USA. https:\/\/doi.org\/10.1073\/pnas.2022172118","journal-title":"Proc Natl Acad Sci USA"},{"key":"3474_CR25","doi-asserted-by":"publisher","first-page":"e519","DOI":"10.1016\/j.wneu.2018.09.155","volume":"121","author":"C Liao","year":"2019","unstructured":"Liao C, Chen W, Wang J (2019) MicroRNA-20a regulates glioma cell proliferation, invasion, and apoptosis by targeting CUGBP Elav-like family member 2. World Neurosurg 121:e519\u2013e527","journal-title":"World Neurosurg"},{"key":"3474_CR26","first-page":"3811","volume":"8","author":"XJ Liu","year":"2015","unstructured":"Liu XJ, Zheng XP, Zhang R, Guo YL, Wang JH (2015) Combinatorial effects of miR-20a and miR-29b on neuronal apoptosis induced by spinal cord injury. Int J Clin Exp Pathol 8:3811\u20133818","journal-title":"Int J Clin Exp Pathol"},{"key":"3474_CR27","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1080\/15384101.2020.1856498","volume":"20","author":"CC Yang","year":"2021","unstructured":"Yang CC, Wei XP, Fu XM, Qian LT, Xie LJ, Liu HB, Li G, Li XG, Zeng XW (2021) Down-regulating microRNA-20a regulates CDH1 to protect against cerebral ischemia\/reperfusion injury in rats. Cell Cycle 20:54\u201364","journal-title":"Cell Cycle"},{"key":"3474_CR28","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1083\/jcb.200307130","volume":"163","author":"PR Potts","year":"2003","unstructured":"Potts PR, Singh S, Knezek M, Thompson CB, Deshmukh M (2003) Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis. J Cell Biol 163:789\u2013799","journal-title":"J Cell Biol"},{"key":"3474_CR29","doi-asserted-by":"publisher","first-page":"105715","DOI":"10.1016\/j.biocel.2020.105715","volume":"121","author":"R Zhao","year":"2020","unstructured":"Zhao R, Yu Q, Hou L, Dong X, Zhang H, Chen X, Zhou Z, Ma J, Huang S, Chen L (2020) Cadmium induces mitochondrial ROS inactivation of XIAP pathway leading to apoptosis in neuronal cells. Int J Biochem Cell Biol 121:105715","journal-title":"Int J Biochem Cell Biol"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-021-03474-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-021-03474-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-021-03474-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T08:17:55Z","timestamp":1644913075000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-021-03474-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,19]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["3474"],"URL":"https:\/\/doi.org\/10.1007\/s11064-021-03474-z","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,19]]},"assertion":[{"value":"19 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 October 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 October 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}