{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T22:16:46Z","timestamp":1772662606326,"version":"3.50.1"},"reference-count":157,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1007\/s11064-021-03500-0","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:04:44Z","timestamp":1641513884000},"page":"825-843","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Mechanistic Insight on Autophagy Modulated Molecular Pathways in Cerebral Ischemic Injury: From Preclinical to Clinical Perspective"],"prefix":"10.1007","volume":"47","author":[{"given":"Palak","family":"Kalra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heena","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amarjot","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2979-1590","authenticated-orcid":false,"given":"Thakur Gurjeet","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,7]]},"reference":[{"key":"3500_CR1","doi-asserted-by":"publisher","first-page":"7609","DOI":"10.3390\/ijms21207609","volume":"21","author":"D Kuriakose","year":"2020","unstructured":"Kuriakose D, Xiao Z (2020) Pathophysiology and treatment of stroke: present status and future perspectives. Int J Mol Sci 21:7609. https:\/\/doi.org\/10.3390\/ijms21207609","journal-title":"Int J Mol Sci"},{"key":"3500_CR2","doi-asserted-by":"publisher","first-page":"924","DOI":"10.14336\/AD.2017.1126","volume":"9","author":"F Liu","year":"2018","unstructured":"Liu F, Lu J, Manaenko A, Tang J, Hu Q (2018) Mitochondria in ischemic stroke: new insight and implications. Aging Dis 9:924","journal-title":"Aging Dis"},{"key":"3500_CR3","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.jddst.2015.07.018","volume":"30","author":"A Gaudin","year":"2015","unstructured":"Gaudin A, Andrieux K, Couvreur P (2015) Nanomedicines and stroke: toward translational research. J Drug Deliv Sci Technol 30:278\u2013299. https:\/\/doi.org\/10.1016\/j.jddst.2015.07.018","journal-title":"J Drug Deliv Sci Technol"},{"key":"3500_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1734-1140(12)70725-9","volume":"64","author":"B Gabryel","year":"2012","unstructured":"Gabryel B, Kost A, Kasprowska D (2012) Neuronal autophagy in cerebral ischemia\u2014a potential target for neuroprotective strategies? Pharmacol Rep 64:1\u20135. https:\/\/doi.org\/10.1016\/S1734-1140(12)70725-9","journal-title":"Pharmacol Rep"},{"key":"3500_CR5","doi-asserted-by":"publisher","first-page":"454680","DOI":"10.1155\/2015\/454680","volume":"2015","author":"G Frati","year":"2015","unstructured":"Frati G, Benedetto U, Biondi-Zoccai G, Sciarretta S (2015) Bridging the gap between translational and outcome research in cardiovascular disease. Biomed Res Int 2015:454680. https:\/\/doi.org\/10.1155\/2015\/454680","journal-title":"Biomed Res Int"},{"key":"3500_CR6","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1136\/jim-2016-000104","volume":"64","author":"EH Lo","year":"2016","unstructured":"Lo EH, Ning M (2016) Mechanisms and challenges in translational stroke research. J Investig Med 64:827\u2013829. https:\/\/doi.org\/10.1136\/jim-2016-000104","journal-title":"J Investig Med"},{"key":"3500_CR7","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1161\/CIRCULATIONAHA.109.917948","volume":"121","author":"MS Lauer","year":"2010","unstructured":"Lauer MS, Skarlatos S (2010) Translational research for cardiovascular diseases at the National Heart, Lung, and Blood Institute: moving from bench to bedside and from bedside to community. Circulation 121:929\u2013933. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.109.917948","journal-title":"Circulation"},{"key":"3500_CR8","doi-asserted-by":"publisher","first-page":"2079","DOI":"10.1093\/brain\/awx126","volume":"140","author":"AA Neuhaus","year":"2017","unstructured":"Neuhaus AA, Couch Y, Hadley G, Buchan AM (2017) Neuroprotection in stroke: the importance of collaboration and reproducibility. Brain 140:2079\u20132092. https:\/\/doi.org\/10.1093\/brain\/awx126","journal-title":"Brain"},{"key":"3500_CR9","doi-asserted-by":"publisher","first-page":"62","DOI":"10.4103\/tp.TP_47_17","volume":"7","author":"J Mandal","year":"2017","unstructured":"Mandal J, Ponnambath DK, Parija SC (2017) Ethics of translational medical research. Trop Parasitol 7:62. https:\/\/doi.org\/10.4103\/tp.TP_47_17","journal-title":"Trop Parasitol"},{"key":"3500_CR10","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1097\/ACM.0b013e3181ccd618","volume":"85","author":"DM Rubio","year":"2010","unstructured":"Rubio DM, Schoenbaum EE, Lee LS, Schteingart DE, Marantz PR, Anderson KE, Platt LD, Baez A, Esposito K (2010) Defining translational research: implications for training. Acad Med 85:470. https:\/\/doi.org\/10.1097\/ACM.0b013e3181ccd618","journal-title":"Acad Med"},{"key":"3500_CR11","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0166-2236(99)01401-0","volume":"22","author":"U Dirnagl","year":"1999","unstructured":"Dirnagl U, Iadecola C, Moskowitz MA (1999) Pathobiology of ischemic stroke: an integrated view. Trends Neurosci 22:391\u2013397. https:\/\/doi.org\/10.1016\/S0166-2236(99)01401-0","journal-title":"Trends Neurosci"},{"key":"3500_CR12","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1002\/ana.20741","volume":"59","author":"VE O'Collins","year":"2006","unstructured":"O\u2019Collins VE, Macleod MR, Donnan GA, Horky LL, Van Der Worp BH, Howells DW (2006) 1,026 experimental treatments in acute stroke. Ann Neurol 59:467\u2013477. https:\/\/doi.org\/10.1002\/ana.20741","journal-title":"Ann Neurol"},{"key":"3500_CR13","doi-asserted-by":"publisher","first-page":"2123","DOI":"10.1161\/01.STR.0000025518.34157.51","volume":"33","author":"DJ Gladstone","year":"2002","unstructured":"Gladstone DJ, Black SE, Hakim AM (2002) Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions. Stroke 33:2123\u20132136. https:\/\/doi.org\/10.1161\/01.STR.0000025518.34157.51","journal-title":"Stroke"},{"key":"3500_CR14","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/jnc.13516","volume":"139","author":"G Llovera","year":"2016","unstructured":"Llovera G, Liesz A (2016) The next step in translational research: lessons learned from the first preclinical randomized controlled trial. J Neurochem 139:271\u2013279. https:\/\/doi.org\/10.1111\/jnc.13516","journal-title":"J Neurochem"},{"key":"3500_CR15","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1139\/cjpp-2019-0188","volume":"97","author":"AK Grewal","year":"2019","unstructured":"Grewal AK, Singh N, Singh TG (2019) Effects of resveratrol postconditioning on cerebral ischemia in mice: role of the sirtuin-1 pathway. Can J Physiol Pharmacol 97:1094\u20131101. https:\/\/doi.org\/10.1139\/cjpp-2019-0188","journal-title":"Can J Physiol Pharmacol"},{"key":"3500_CR16","first-page":"3772","volume":"20","author":"AK Grewal","year":"2020","unstructured":"Grewal AK, Singh TG, Singh N (2020) Potential herbal drugs for ischemic stroke: a review. Plant Arch 20:3772\u20133783","journal-title":"Plant Arch"},{"key":"3500_CR17","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1602\/neurorx.1.1.36","volume":"1","author":"YD Cheng","year":"2004","unstructured":"Cheng YD, Al-Khoury L, Zivin JA (2004) Neuroprotection for ischemic stroke: two decades of success and failure. NeuroRx 1:36\u201345","journal-title":"NeuroRx"},{"key":"3500_CR18","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1159\/000356320","volume":"92","author":"H Kaur","year":"2013","unstructured":"Kaur H, Prakash A, Kaur Medhi B (2013) Drug therapy in stroke: from preclinical to clinical studies. Pharmacology 92:324\u2013334. https:\/\/doi.org\/10.1159\/000356320","journal-title":"Pharmacology"},{"key":"3500_CR19","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nchembio.1269","volume":"9","author":"N Editorial","year":"2013","unstructured":"Editorial N (2013) Facilitating reproducibility. Nat Chem Biol 9:345","journal-title":"Nat Chem Biol"},{"key":"3500_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s41231-019-0050-7","volume":"4","author":"AA Seyhan","year":"2019","unstructured":"Seyhan AA (2019) Lost in translation: the valley of death across preclinical and clinical divide\u2013identification of problems and overcoming obstacles. Transl Med Commun 4:1\u20139. https:\/\/doi.org\/10.1186\/s41231-019-0050-7","journal-title":"Transl Med Commun"},{"key":"3500_CR21","doi-asserted-by":"publisher","first-page":"118975","DOI":"10.1016\/j.lfs.2020.118975","volume":"31","author":"K Thapa","year":"2020","unstructured":"Thapa K, Khan H, Sharma U, Grewal AK, Singh TG (2020) Poly (ADP-ribose) polymerase-1 as a promising drug target for neurodegenerative diseases. Life Sci 31:118975. https:\/\/doi.org\/10.1016\/j.lfs.2020.118975","journal-title":"Life Sci"},{"key":"3500_CR22","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3389\/fncel.2020.00051","volume":"14","author":"D Belov Kirdajova","year":"2020","unstructured":"Belov Kirdajova D, Kriska J, Tureckova J, Anderova M (2020) Ischemia-triggered glutamate excitotoxicity from the perspective of glial cells. Front Cell Neurosci 14:51. https:\/\/doi.org\/10.3389\/fncel.2020.00051","journal-title":"Front Cell Neurosci"},{"key":"3500_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2021.03.009","author":"S Singh","year":"2021","unstructured":"Singh S, Singh TG, Rehni AK, Sharma V, Singh M, Kaur R (2021) Reviving mitochondrial bioenergetics: a relevant approach in epilepsy. Mitochondrion. https:\/\/doi.org\/10.1016\/j.mito.2021.03.009","journal-title":"Mitochondrion"},{"key":"3500_CR24","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s12640-018-9911-5","volume":"34","author":"O Rebai","year":"2018","unstructured":"Rebai O, Amri M (2018) Chlorogenic acid prevents AMPA-mediated excitotoxicity in optic nerve oligodendrocytes through a PKC and caspase-dependent pathways. Neurotox Res 34:559\u2013573","journal-title":"Neurotox Res"},{"key":"3500_CR25","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.redox.2018.03.002","volume":"16","author":"JL Yang","year":"2018","unstructured":"Yang JL, Mukda S, Chen SD (2018) Diverse roles of mitochondria in ischemic stroke. Redox Biol 16:263\u2013275. https:\/\/doi.org\/10.1016\/j.redox.2018.03.002","journal-title":"Redox Biol"},{"key":"3500_CR26","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.pneurobio.2018.01.001","volume":"163","author":"P Wang","year":"2018","unstructured":"Wang P, Shao BZ, Deng Z, Chen S, Yue Z, Miao CY (2018) Autophagy in ischemic stroke. Prog Neurobiol 163:98\u2013117. https:\/\/doi.org\/10.1016\/j.pneurobio.2018.01.001","journal-title":"Prog Neurobiol"},{"key":"3500_CR27","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1089\/ars.2013.5371","volume":"20","author":"KR Parzych","year":"2014","unstructured":"Parzych KR, Klionsky DJ (2014) An overview of autophagy: morphology, mechanism, and regulation. Antioxid Redox Signal 20:460\u2013473. https:\/\/doi.org\/10.1089\/ars.2013.5371","journal-title":"Antioxid Redox Signal"},{"key":"3500_CR28","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1007\/s00109-016-1461-9","volume":"94","author":"AR Ariosa","year":"2016","unstructured":"Ariosa AR, Klionsky DJ (2016) Autophagy core machinery: overcoming spatial barriers in neurons. J Mol Med 94:1217\u20131227","journal-title":"J Mol Med"},{"key":"3500_CR29","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8372647","author":"M Wang","year":"2020","unstructured":"Wang M, Lee H, Elkin K, Bardhi R, Guan L, Chandra A, Geng X, Ding Y (2020) Detrimental and beneficial effect of autophagy and a potential therapeutic target after ischemic stroke. Evid Based Complement Altern Med. https:\/\/doi.org\/10.1155\/2020\/8372647","journal-title":"Evid Based Complement Altern Med"},{"key":"3500_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4161\/auto.1.1.1270","volume":"1","author":"EL Eskelinen","year":"2005","unstructured":"Eskelinen EL (2005) Maturation of autophagic vacuoles in mammalian cells. Autophagy 1:1. https:\/\/doi.org\/10.4161\/auto.1.1.1270","journal-title":"Autophagy"},{"key":"3500_CR31","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/j.1365-2990.2009.01034.x","volume":"35","author":"A Rami","year":"2009","unstructured":"Rami A (2009) Autophagy in neurodegeneration: firefighter and\/or incendiarist? Neuropathol Appl Neurobiol 35:449\u2013461. https:\/\/doi.org\/10.1111\/j.1365-2990.2009.01034.x","journal-title":"Neuropathol Appl Neurobiol"},{"key":"3500_CR32","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/nrd3802","volume":"11","author":"DC Rubinsztein","year":"2012","unstructured":"Rubinsztein DC, Codogno P, Levine B (2012) Autophagy modulation as a potential therapeutic target for diverse diseases. Nat Rev Drug Discov 11:709\u2013730. https:\/\/doi.org\/10.1038\/nrd3802","journal-title":"Nat Rev Drug Discov"},{"key":"3500_CR33","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1161\/CIRCRESAHA.116.303804","volume":"116","author":"GR De Meyer","year":"2015","unstructured":"De Meyer GR, Grootaert MO, Michiels CF, Kurdi A, Schrijvers DM, Martinet W (2015) Autophagy in vascular disease. Circ Res 116:468\u2013479. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.303804","journal-title":"Circ Res"},{"key":"3500_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/JCI78652","volume":"125","author":"G Kroemer","year":"2015","unstructured":"Kroemer G (2015) Autophagy: a druggable process that is deregulated in aging and human disease. J Clin Investig 125:1\u20134","journal-title":"J Clin Investig"},{"key":"3500_CR35","doi-asserted-by":"publisher","first-page":"192","DOI":"10.4161\/auto.26927","volume":"10","author":"P Chen","year":"2014","unstructured":"Chen P, Cescon M, Bonaldo P (2014) Autophagy-mediated regulation of macrophages and its applications for cancer. Autophagy 10:192\u2013200. https:\/\/doi.org\/10.4161\/auto.26927","journal-title":"Autophagy"},{"key":"3500_CR36","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.tips.2014.09.002","volume":"35","author":"RL Vidal","year":"2014","unstructured":"Vidal RL, Matus S, Bargsted L, Hetz C (2014) Targeting autophagy in neurodegenerative diseases. Trends Pharmacol Sci 35:583\u2013591. https:\/\/doi.org\/10.1016\/j.tips.2014.09.002","journal-title":"Trends Pharmacol Sci"},{"key":"3500_CR37","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.4161\/auto.21212","volume":"8","author":"XJ Zhou","year":"2012","unstructured":"Zhou XJ, Zhang H (2012) Autophagy in immunity: implications in etiology of autoimmune\/autoinflammatory diseases. Autophagy 8:1286\u20131299. https:\/\/doi.org\/10.4161\/auto.21212","journal-title":"Autophagy"},{"key":"3500_CR38","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/S2095-4964(15)60187-X","volume":"13","author":"XP Huang","year":"2015","unstructured":"Huang XP, Ding H, Lu JD, Tang YH, Deng BX, Deng CQ (2015) Autophagy in cerebral ischemia and the effects of traditional Chinese medicine. J Integr Med 13:289\u2013296. https:\/\/doi.org\/10.1016\/S2095-4964(15)60187-X","journal-title":"J Integr Med"},{"key":"3500_CR39","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/978-3-319-04981-6_7","volume-title":"Neurovascular events after subarachnoid hemorrhage: focusing on subcellular organelles. Neurovascular events after subarachnoid hemorrhage","author":"S Chen","year":"2015","unstructured":"Chen S, Wu H, Tang J, Zhang J, Zhang JH (2015) Neurovascular events after subarachnoid hemorrhage: focusing on subcellular organelles. Neurovascular events after subarachnoid hemorrhage. Springer, Cham, pp 39\u201346"},{"key":"3500_CR40","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s12031-013-0132-3","volume":"52","author":"P Chang","year":"2014","unstructured":"Chang P, Dong W, Zhang M, Wang Z, Wang Y, Wang T, Gao Y, Meng H, Luo B, Luo C, Chen X (2014) Anti-necroptosis chemical necrostatin-1 can also suppress apoptotic and autophagic pathway to exert neuroprotective effect in mice intracerebral hemorrhage model. J Mol Neurosci 52:242\u2013249","journal-title":"J Mol Neurosci"},{"key":"3500_CR41","doi-asserted-by":"publisher","first-page":"28","DOI":"10.4161\/15548627.2014.984267","volume":"11","author":"Y Xie","year":"2015","unstructured":"Xie Y, Kang R, Sun X, Zhong M, Huang J, Klionsky DJ, Tang D (2015) Posttranslational modification of autophagy-related proteins in macroautophagy. Autophagy 11:28\u201345. https:\/\/doi.org\/10.4161\/15548627.2014.984267","journal-title":"Autophagy"},{"key":"3500_CR42","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1038\/ncb2757","volume":"15","author":"RC Russell","year":"2013","unstructured":"Russell RC, Tian Y, Yuan H, Park HW, Chang YY, Kim J, Kim H, Neufeld TP, Dillin A, Guan KL (2013) ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol 15:741\u2013750. https:\/\/doi.org\/10.1038\/ncb2757","journal-title":"Nat Cell Biol"},{"key":"3500_CR43","doi-asserted-by":"publisher","first-page":"11971","DOI":"10.3390\/ijms222111971","volume":"22","author":"A Sharma","year":"2021","unstructured":"Sharma A, Khan H, Singh TG, Grewal AK, Najda A, Kawecka-Radomska M, Kamel M, Altyar AE, Del-Daim MM (2021) Pharmacological modulation of ubiquitin-proteasome pathways in oncogenic signaling. Int J Mol Sci 22:11971. https:\/\/doi.org\/10.3390\/ijms222111971","journal-title":"Int J Mol Sci"},{"key":"3500_CR44","doi-asserted-by":"publisher","first-page":"762","DOI":"10.4161\/auto.6412","volume":"4","author":"YD Wen","year":"2008","unstructured":"Wen YD, Sheng R, Zhang LS, Han R, Zhang X, Zhang XD, Han F, Fukunaga K, Qin ZH (2008) Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy 4:762\u2013769. https:\/\/doi.org\/10.4161\/auto.6412","journal-title":"Autophagy"},{"key":"3500_CR45","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.jns.2019.03.015","volume":"400","author":"K Hou","year":"2019","unstructured":"Hou K, Xu D, Li F, Chen S, Li Y (2019) The progress of neuronal autophagy in cerebral ischemia stroke: mechanisms, roles and research methods. J Neurol Sci 400:72\u201382. https:\/\/doi.org\/10.1016\/j.jns.2019.03.015","journal-title":"J Neurol Sci"},{"key":"3500_CR46","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1523\/JNEUROSCI.15-02-01001.1995","volume":"15","author":"T Nitatori","year":"1995","unstructured":"Nitatori T, Sato N, Waguri S, Karasawa Y, Araki H, Shibanai K, Kominami E, Uchiyama Y (1995) Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J Neurosci 15:1001\u20131011. https:\/\/doi.org\/10.1523\/JNEUROSCI.15-02-01001.1995","journal-title":"J Neurosci"},{"key":"3500_CR47","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.brainres.2011.05.049","volume":"1402","author":"W Yan","year":"2011","unstructured":"Yan W, Zhang H, Bai X, Lu Y, Dong H, Xiong L (2011) Autophagy activation is involved in neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats. Brain Res 1402:109\u2013121. https:\/\/doi.org\/10.1016\/j.brainres.2011.05.049","journal-title":"Brain Res"},{"key":"3500_CR48","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.4103\/1673-5374.187027","volume":"11","author":"YH Deng","year":"2016","unstructured":"Deng YH, He HY, Yang LQ, Zhang PY (2016) Dynamic changes in neuronal autophagy and apoptosis in the ischemic penumbra following permanent ischemic stroke. Neural Regen Res 11:1108","journal-title":"Neural Regen Res"},{"key":"3500_CR49","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/B978-0-12-815762-6.00008-1","volume-title":"Clinical perspectives and targeted therapies in apoptosis","author":"RK Sodhi","year":"2021","unstructured":"Sodhi RK, Grewal AK, Madan J, Jhajj TG, Kumar R (2021) Recent approaches to target apoptosis in neurological disorders. Clinical perspectives and targeted therapies in apoptosis. Academic Press, Cambridge, pp 217\u2013283. https:\/\/doi.org\/10.1016\/B978-0-12-815762-6.00008-1"},{"key":"3500_CR50","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1111\/jphp.13336","volume":"72","author":"H Khan","year":"2020","unstructured":"Khan H, Kashyap A, Kaur A, Singh TG (2020) Pharmacological postconditioning: a molecular aspect in ischemic injury. J Pharm Pharmacol 72:1513\u20131527. https:\/\/doi.org\/10.1111\/jphp.13336","journal-title":"J Pharm Pharmacol"},{"key":"3500_CR51","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3389\/fnins.2018.00405","volume":"12","author":"T Zhang","year":"2018","unstructured":"Zhang T, Lu D, Yang W, Shi C, Zang J, Shen L, Mai H, Xu A (2018) HMG-CoA reductase inhibitors relieve endoplasmic reticulum stress by autophagy inhibition in rats with permanent brain ischemia. Front Neurosci 12:405. https:\/\/doi.org\/10.3389\/fnins.2018.00405","journal-title":"Front Neurosci"},{"key":"3500_CR52","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.expneurol.2018.05.022","volume":"307","author":"J Yu","year":"2018","unstructured":"Yu J, Li X, Matei N, McBride D, Tang J, Yan M, Zhang JH (2018) Ezetimibe, a NPC1L1 inhibitor, attenuates neuronal apoptosis through AMPK dependent autophagy activation after MCAO in rats. Exp Neurol 307:12\u201323. https:\/\/doi.org\/10.1016\/j.expneurol.2018.05.022","journal-title":"Exp Neurol"},{"key":"3500_CR53","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.nbd.2008.07.022","volume":"32","author":"S Carloni","year":"2008","unstructured":"Carloni S, Buonocore G, Balduini W (2008) Protective role of autophagy in neonatal hypoxia\u2013ischemia induced brain injury. Neurobiol Dis 32:329\u2013339. https:\/\/doi.org\/10.1016\/j.nbd.2008.07.022","journal-title":"Neurobiol Dis"},{"key":"3500_CR54","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.bbrc.2014.01.032","volume":"444","author":"Q Li","year":"2014","unstructured":"Li Q, Zhang T, Wang J, Zhang Z, Zhai Y, Yang GY, Sun X (2014) Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke. Biochem Biophys Res Commun 444:182\u2013188. https:\/\/doi.org\/10.1016\/j.bbrc.2014.01.032","journal-title":"Biochem Biophys Res Commun"},{"key":"3500_CR55","doi-asserted-by":"publisher","first-page":"566","DOI":"10.2353\/ajpath.2006.051066","volume":"169","author":"F Adhami","year":"2006","unstructured":"Adhami F, Liao G, Morozov YM, Schloemer A, Schmithorst VJ, Lorenz JN, Dunn RS, Vorhees CV, Wills-Karp M, Degen JL, Davis RJ (2006) Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy. Am J Pathol 169:566\u2013583. https:\/\/doi.org\/10.2353\/ajpath.2006.051066","journal-title":"Am J Pathol"},{"key":"3500_CR56","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1074\/jbc.M804396200","volume":"284","author":"L Du","year":"2009","unstructured":"Du L, Hickey RW, Bayir H, Watkins SC, Tyurin VA, Guo F, Kochanek PM, Jenkins LW, Ren J, Gibson G, Chu CT (2009) Starving neurons show sex difference in autophagy. J Biol Chem 284:2383\u20132396. https:\/\/doi.org\/10.1074\/jbc.M804396200","journal-title":"J Biol Chem"},{"key":"3500_CR57","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/jcbfm.2009.255","volume":"30","author":"J Li","year":"2010","unstructured":"Li J, McCullough LD (2010) Effects of AMP-activated protein kinase in cerebral ischemia. J Cereb Blood Flow Metab 30:480\u2013492. https:\/\/doi.org\/10.1038\/jcbfm.2009.255","journal-title":"J Cereb Blood Flow Metab"},{"key":"3500_CR58","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/978-981-15-4272-5_7","volume-title":"Autophagy: biology and diseases","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Cao Y, Liu C (2020) Autophagy and ischemic stroke. Autophagy: biology and diseases. Springer, Singapore, pp 111\u2013134. https:\/\/doi.org\/10.1007\/978-981-15-4272-5_7"},{"key":"3500_CR59","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1097\/NEN.0b013e31821352bd","volume":"70","author":"JY Wang","year":"2011","unstructured":"Wang JY, Xia Q, Chu KT, Pan J, Sun LN, Zeng B, Zhu YJ, Wang Q, Wang K, Luo BY (2011) Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: a widely used inhibitor of autophagy. J Neuropathol Exp Neurol 70:314\u2013322. https:\/\/doi.org\/10.1097\/NEN.0b013e31821352bd","journal-title":"J Neuropathol Exp Neurol"},{"key":"3500_CR60","doi-asserted-by":"publisher","first-page":"42","DOI":"10.4161\/auto.3412","volume":"3","author":"F Adhami","year":"2007","unstructured":"Adhami F, Schloemer A, Kuan CY (2007) The roles of autophagy in cerebral ischemia. Autophagy 3:42\u201344. https:\/\/doi.org\/10.4161\/auto.3412","journal-title":"Autophagy"},{"key":"3500_CR61","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aav3530","author":"S Martens","year":"2018","unstructured":"Martens S (2018) A division of labor in mTORC1 signaling and autophagy. Sci Signal. https:\/\/doi.org\/10.1126\/scisignal.aav3530","journal-title":"Sci Signal"},{"key":"3500_CR62","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1161\/CIRCRESAHA.117.311147","volume":"122","author":"S Sciarretta","year":"2018","unstructured":"Sciarretta S, Forte M, Frati G, Sadoshima J (2018) New insights into the role of mTOR signaling in the cardiovascular system. Circ Res 122:489\u2013505. https:\/\/doi.org\/10.1161\/CIRCRESAHA.117.311147","journal-title":"Circ Res"},{"key":"3500_CR63","doi-asserted-by":"publisher","first-page":"12562","DOI":"10.1002\/jcp.28125","volume":"234","author":"B Shi","year":"2019","unstructured":"Shi B, Ma M, Zheng Y, Pan Y, Lin X (2019) mTOR and Beclin1: two key autophagy-related molecules and their roles in myocardial ischemia\/reperfusion injury. J Cell Physiol 234:12562\u201312568. https:\/\/doi.org\/10.1002\/jcp.28125","journal-title":"J Cell Physiol"},{"key":"3500_CR64","doi-asserted-by":"publisher","first-page":"878","DOI":"10.7150\/ijbs.18976","volume":"13","author":"C Hei","year":"2017","unstructured":"Hei C, Liu P, Yang X, Niu J, Li PA (2017) Inhibition of mTOR signaling confers protection against cerebral ischemic injury in acute hyperglycemic rats. Int J Biol Sci 13:878","journal-title":"Int J Biol Sci"},{"key":"3500_CR65","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.3389\/fnins.2018.01022","volume":"12","author":"Y Sun","year":"2019","unstructured":"Sun Y, Zhu Y, Zhong X, Chen X, Wang J, Ying G (2019) Crosstalk between autophagy and cerebral ischemia. Front Neurosci 12:1022. https:\/\/doi.org\/10.3389\/fnins.2018.01022","journal-title":"Front Neurosci"},{"key":"3500_CR66","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1002\/cbin.10915","volume":"42","author":"R Ke","year":"2018","unstructured":"Ke R, Xu Q, Li C, Luo L, Huang D (2018) Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism. Cell Biol Int 42:384\u2013392. https:\/\/doi.org\/10.1002\/cbin.10915","journal-title":"Cell Biol Int"},{"key":"3500_CR67","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1089\/ars.2010.3544","volume":"14","author":"P Weisov\u00e1","year":"2011","unstructured":"Weisov\u00e1 P, D\u00e1vila D, Tuffy LP, Ward MW, Concannon CG, Prehn JH (2011) Role of 5\u2032-adenosine monophosphate-activated protein kinase in cell survival and death responses in neurons. Antioxid Redox Signal 14:1863\u20131876. https:\/\/doi.org\/10.1089\/ars.2010.3544","journal-title":"Antioxid Redox Signal"},{"key":"3500_CR68","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.molcel.2017.05.032","volume":"66","author":"D Garcia","year":"2017","unstructured":"Garcia D, Shaw RJ (2017) AMPK: mechanisms of cellular energy sensing and restoration of metabolic balance. Mol Cell 66:789\u2013800. https:\/\/doi.org\/10.1016\/j.molcel.2017.05.032","journal-title":"Mol Cell"},{"key":"3500_CR69","doi-asserted-by":"publisher","first-page":"119843","DOI":"10.1016\/j.lfs.2021.119843","volume":"21","author":"K Thapa","year":"2021","unstructured":"Thapa K, Singh TG, Kaur A (2021) Cyclic nucleotide phosphodiesterase inhibition as a potential therapeutic target in renal ischemia reperfusion injury. Life Sci 21:119843. https:\/\/doi.org\/10.1016\/j.lfs.2021.119843","journal-title":"Life Sci"},{"key":"3500_CR70","doi-asserted-by":"publisher","first-page":"989","DOI":"10.4103\/1673-5374.233441","volume":"13","author":"JF Wang","year":"2018","unstructured":"Wang JF, Mei ZG, Fu Y, Yang SB, Zhang SZ, Huang WF, Xiong L, Zhou HJ, Tao W, Feng ZT (2018) Puerarin protects rat brain against ischemia\/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway. Neural Regen Res 13:989","journal-title":"Neural Regen Res"},{"key":"3500_CR71","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1189\/jlb.0212053","volume":"92","author":"EP Thi","year":"2012","unstructured":"Thi EP, Reiner NE (2012) Phosphatidylinositol 3-kinases and their roles in phagosome maturation. J Leukoc Biol 92:553\u2013566. https:\/\/doi.org\/10.1189\/jlb.0212053","journal-title":"J Leukoc Biol"},{"key":"3500_CR72","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.gene.2019.02.076","volume":"698","author":"S Noorolyai","year":"2019","unstructured":"Noorolyai S, Shajari N, Baghbani E, Sadreddini S, Baradaran B (2019) The relation between PI3K\/AKT signalling pathway and cancer. Gene 698:120\u2013128. https:\/\/doi.org\/10.1016\/j.gene.2019.02.076","journal-title":"Gene"},{"key":"3500_CR73","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3390\/biom9020067","volume":"9","author":"I Yudushkin","year":"2019","unstructured":"Yudushkin I (2019) Getting the Akt together: guiding intracellular Akt activity by PI3K. Biomolecules 9:67. https:\/\/doi.org\/10.3390\/biom9020067","journal-title":"Biomolecules"},{"key":"3500_CR74","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jbior.2014.04.001","volume":"55","author":"A Toker","year":"2014","unstructured":"Toker A, Marmiroli S (2014) Signaling specificity in the Akt pathway in biology and disease. Adv Biol Regul 55:28\u201338. https:\/\/doi.org\/10.1016\/j.jbior.2014.04.001","journal-title":"Adv Biol Regul"},{"key":"3500_CR75","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1128\/MCB.06159-11","volume":"32","author":"S Alers","year":"2012","unstructured":"Alers S, L\u00f6ffler AS, Wesselborg S, Stork B (2012) Role of AMPK-mTOR-Ulk1\/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. J Mol Cell Biol 32:2\u201311. https:\/\/doi.org\/10.1128\/MCB.06159-11","journal-title":"J Mol Cell Biol"},{"key":"3500_CR76","doi-asserted-by":"crossref","unstructured":"Chen AC, Arany PR, Huang YY, Tomkinson EM, Saleem T, Yull FE, Blackwell TS, Hamblin MR (2009) Low level laser therapy activates NF-kB via generation of reactive oxygen species in mouse embryonic fibroblasts. In: Mechanisms for low-light therapy IV 2009 Feb 18, Vol. 7165, International Society for Optics and Photonics, p. 71650B","DOI":"10.1117\/12.809605"},{"key":"3500_CR77","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.neuroscience.2013.04.054","volume":"246","author":"DR Cui","year":"2013","unstructured":"Cui DR, Wang L, Jiang W, Qi AH, Zhou QH, Zhang XL (2013) Propofol prevents cerebral ischemia-triggered autophagy activation and cell death in the rat hippocampus through the NF-\u03baB\/p53 signaling pathway. Neuroscience 246:117\u2013132. https:\/\/doi.org\/10.1016\/j.neuroscience.2013.04.054","journal-title":"Neuroscience"},{"key":"3500_CR78","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.biopha.2018.10.155","volume":"109","author":"A Gupta","year":"2019","unstructured":"Gupta A, Shah K, Oza MJ, Behl T (2019) Reactivation of p53 gene by MDM2 inhibitors: a novel therapy for cancer treatment. Biomed Pharmacother 109:484\u2013492. https:\/\/doi.org\/10.1016\/j.biopha.2018.10.155","journal-title":"Biomed Pharmacother"},{"key":"3500_CR79","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.2147\/DDDT.S194182","volume":"13","author":"Y Hou","year":"2019","unstructured":"Hou Y, Wang J, Feng J (2019) The neuroprotective effects of curcumin are associated with the regulation of the reciprocal function between autophagy and HIF-1\u03b1 in cerebral ischemia-reperfusion injury. Drug Des Dev Ther 13:1135","journal-title":"Drug Des Dev Ther"},{"key":"3500_CR80","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.4103\/1673-5374.274331","volume":"15","author":"Y Mo","year":"2020","unstructured":"Mo Y, Sun YY, Liu KY (2020) Autophagy and inflammation in ischemic stroke. Neural Regen Res 15:1388","journal-title":"Neural Regen Res"},{"key":"3500_CR81","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1007\/s12031-018-1162-7","volume":"66","author":"N Lu","year":"2018","unstructured":"Lu N, Li X, Tan R, An J, Cai Z, Hu X, Wang F, Wang H, Lu C, Lu H (2018) HIF-1\u03b1\/Beclin1-mediated autophagy is involved in neuroprotection induced by hypoxic preconditioning. J Mol Neurosci 66:238\u2013250","journal-title":"J Mol Neurosci"},{"key":"3500_CR82","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1080\/15548627.2017.1357792","volume":"13","author":"Y Yuan","year":"2017","unstructured":"Yuan Y, Zheng Y, Zhang X, Chen Y, Wu X, Wu J, Shen Z, Jiang L, Wang L, Yang W, Luo J (2017) BNIP3L\/NIX-mediated mitophagy protects against ischemic brain injury independent of PARK2. Autophagy 13:1754\u20131766. https:\/\/doi.org\/10.1080\/15548627.2017.1357792","journal-title":"Autophagy"},{"key":"3500_CR83","first-page":"1","volume":"20","author":"A Mannan","year":"2021","unstructured":"Mannan A, Garg N, Singh TG, Kang HK (2021) Peroxisome proliferator-activated receptor-gamma (PPAR-\u0263): molecular effects and its importance as a novel therapeutic target for cerebral ischemic injury. Neurochem Res 20:1\u201332","journal-title":"Neurochem Res"},{"key":"3500_CR84","doi-asserted-by":"publisher","first-page":"e55080","DOI":"10.1371\/journal.pone.0055080","volume":"8","author":"F Xu","year":"2013","unstructured":"Xu F, Li J, Ni W, Shen YW, Zhang XP (2013) Peroxisome proliferator-activated receptor-\u03b3 agonist 15d-prostaglandin J2 mediates neuronal autophagy after cerebral ischemia-reperfusion injury. PLoS ONE 8:e55080. https:\/\/doi.org\/10.1371\/journal.pone.0055080","journal-title":"PLoS ONE"},{"key":"3500_CR85","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1007\/s12975-015-0393-y","volume":"6","author":"Z Qi","year":"2015","unstructured":"Qi Z, Dong W, Shi W, Wang R, Zhang C, Zhao Y, Ji X, Liu KJ, Luo Y (2015) Bcl-2 phosphorylation triggers autophagy switch and reduces mitochondrial damage in limb remote ischemic conditioned rats after ischemic stroke. Transl Stroke Res 6:198\u2013206","journal-title":"Transl Stroke Res"},{"key":"3500_CR86","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1038\/sj.emboj.7601689","volume":"26","author":"MC Maiuri","year":"2007","unstructured":"Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, Juin P, Tasdemir E, Pierron G, Troulinaki K, Tavernarakis N, Hickman JA (2007) Functional and physical interaction between Bcl-XL and a BH3-like domain in Beclin-1. EMBO J 26:2527\u20132539. https:\/\/doi.org\/10.1038\/sj.emboj.7601689","journal-title":"EMBO J"},{"key":"3500_CR87","doi-asserted-by":"publisher","first-page":"e00199","DOI":"10.1042\/BSR20140141","volume":"35","author":"YY Zhou","year":"2015","unstructured":"Zhou YY, Li Y, Jiang WQ, Zhou LF (2015) MAPK\/JNK signalling: a potential autophagy regulation pathway. Biosci Rep 35:e00199. https:\/\/doi.org\/10.1042\/BSR20140141","journal-title":"Biosci Rep"},{"key":"3500_CR88","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s00401-002-0661-2","volume":"105","author":"I Ferrer","year":"2003","unstructured":"Ferrer I, Friguls B, Dalf\u00f3 E, Planas AM (2003) Early modifications in the expression of mitogen-activated protein kinase (MAPK\/ERK), stress-activated kinases SAPK\/JNK and p38, and their phosphorylated substrates following focal cerebral ischemia. Acta Neuropathol 105:425\u2013437","journal-title":"Acta Neuropathol"},{"key":"3500_CR89","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.jns.2015.08.004","volume":"357","author":"H Li","year":"2015","unstructured":"Li H, Zhou S, Wu L, Liu K, Zhang Y, Ma G, Wang L (2015) The role of p38MAPK signal pathway in the neuroprotective mechanism of limb postconditioning against rat cerebral ischemia\/reperfusion injury. J Neurol Sci 357:270\u2013275. https:\/\/doi.org\/10.1016\/j.jns.2015.08.004","journal-title":"J Neurol Sci"},{"key":"3500_CR90","first-page":"1","volume":"15","author":"YQ Song","year":"2016","unstructured":"Song YQ, Zou HL, Zhao YJ, Yu LQ, Tan ZX, Kong R (2016) Activation of p38-mitogen-activated protein kinase contributes to ischemia reperfusion in rat brain. Genet Mol Res 15:1\u20133","journal-title":"Genet Mol Res"},{"key":"3500_CR91","first-page":"167","volume":"1206","author":"Z Qi","year":"2019","unstructured":"Qi Z, Chen L (2019) Endoplasmic reticulum stress and autophagy. Autophagy: Biol Dis 1206:167\u2013177","journal-title":"Autophagy: Biol Dis"},{"key":"3500_CR92","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1007\/s12035-014-9029-6","volume":"53","author":"VP Nakka","year":"2016","unstructured":"Nakka VP, Prakash-Babu P, Vemuganti R (2016) Crosstalk between endoplasmic reticulum stress, oxidative stress, and autophagy: potential therapeutic targets for acute CNS injuries. Mol Neurobiol 53:532\u2013544","journal-title":"Mol Neurobiol"},{"key":"3500_CR93","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1038\/sj.cdd.4401984","volume":"14","author":"Y Kouroku","year":"2007","unstructured":"Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, Kumagai H, Ogawa S, Kaufman RJ, Kominami E, Momoi T (2007) ER stress (PERK\/eIF2 \u03b1 phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation. Cell Death Differ 14:230\u2013239","journal-title":"Cell Death Differ"},{"key":"3500_CR94","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.4103\/1673-5374.135329","volume":"9","author":"W Chen","year":"2014","unstructured":"Chen W, Sun Y, Liu K, Sun X (2014) Autophagy: a double-edged sword for neuronal survival after cerebral ischemia. Neural Regen Res 9:1210","journal-title":"Neural Regen Res"},{"key":"3500_CR95","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1177\/0271678X16650218","volume":"37","author":"Z Yu","year":"2017","unstructured":"Yu Z, Sheng H, Liu S, Zhao S, Glembotski CC, Warner DS, Paschen W, Yang W (2017) Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome. J Cereb Blood Flow Metab 37:1069\u20131079. https:\/\/doi.org\/10.1177\/0271678X16650218","journal-title":"J Cereb Blood Flow Metab"},{"key":"3500_CR96","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1089\/ars.2010.3554","volume":"14","author":"J Huang","year":"2011","unstructured":"Huang J, Lam GY, Brumell JH (2011) Autophagy signaling through reactive oxygen species. Antioxid Redox Signal 14:2215\u20132231. https:\/\/doi.org\/10.1089\/ars.2010.3554","journal-title":"Antioxid Redox Signal"},{"issue":"5","key":"3500_CR97","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.semcancer.2013.05.008","volume":"23","author":"F Pietrocola","year":"2013","unstructured":"Pietrocola F, Izzo V, Niso-Santano M, Vacchelli E, Galluzzi L, Maiuri MC, Kroemer G (2013) Regulation of autophagy by stress-responsive transcription factors. Semin Cancer Biol 23(5):310\u2013322","journal-title":"Semin Cancer Biol"},{"key":"3500_CR98","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cell.2006.05.034","volume":"126","author":"D Crighton","year":"2006","unstructured":"Crighton D, Wilkinson S, O\u2019Prey J, Syed N, Smith P, Harrison PR, Gasco M, Garrone O, Crook T, Ryan KM (2006) DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126:121\u2013134. https:\/\/doi.org\/10.1016\/j.cell.2006.05.034","journal-title":"Cell"},{"key":"3500_CR99","first-page":"397","volume":"2","author":"A Puissant","year":"2012","unstructured":"Puissant A, Fenouille N, Auberger P (2012) When autophagy meets cancer through p62\/SQSTM1. Am J Cancer Res 2:397","journal-title":"Am J Cancer Res"},{"key":"3500_CR100","doi-asserted-by":"publisher","first-page":"e87371","DOI":"10.1371\/journal.pone.0087371","volume":"9","author":"PK Mahalingaiah","year":"2014","unstructured":"Mahalingaiah PK, Singh KP (2014) Chronic oxidative stress increases growth and tumorigenic potential of MCF-7 breast cancer cells. PLoS ONE 9:e87371. https:\/\/doi.org\/10.1371\/journal.pone.0087371","journal-title":"PLoS ONE"},{"key":"3500_CR101","doi-asserted-by":"publisher","first-page":"3616","DOI":"10.1128\/MCB.05164-11","volume":"31","author":"A Avivar-Valderas","year":"2011","unstructured":"Avivar-Valderas A, Salas E, Bobrovnikova-Marjon E, Diehl JA, Nagi C, Debnath J, Aguirre-Ghiso JA (2011) PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment. Cell Mol Biol 31:3616\u20133629. https:\/\/doi.org\/10.1128\/MCB.05164-11","journal-title":"Cell Mol Biol"},{"key":"3500_CR102","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1080\/10408363.2019.1575333","volume":"56","author":"SF Nabavi","year":"2019","unstructured":"Nabavi SF, Sureda A, Sanches-Silva A, Pandima Devi K, Ahmed T, Shahid M, Sobarzo-S\u00e1nchez E, Dacrema M, Daglia M, Braidy N, Vacca RA (2019) Novel therapeutic strategies for stroke: the role of autophagy. Crit Rev Clin Lab Sci 56:182\u2013199. https:\/\/doi.org\/10.1080\/10408363.2019.1575333","journal-title":"Crit Rev Clin Lab Sci"},{"key":"3500_CR103","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s10571-015-0166-x","volume":"35","author":"L Li","year":"2015","unstructured":"Li L, Tan J, Miao Y, Lei P, Zhang Q (2015) ROS and autophagy: interactions and molecular regulatory mechanisms. Cell Mol Neurobiol 35:615\u2013621","journal-title":"Cell Mol Neurobiol"},{"key":"3500_CR104","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1038\/sj.emboj.7601623","volume":"26","author":"R Scherz-Shouval","year":"2007","unstructured":"Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z (2007) Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 26:1749\u20131760. https:\/\/doi.org\/10.1038\/sj.emboj.7601623","journal-title":"EMBO J"},{"key":"3500_CR105","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3389\/fphar.2020.00084","volume":"11","author":"X Sun","year":"2020","unstructured":"Sun X, Wang D, Zhang T, Lu X, Duan F, Ju L, Zhuang X, Jiang X (2020) Eugenol attenuates cerebral ischemia-reperfusion injury by enhancing autophagy via AMPK-mTOR-P70S6K pathway. Front Pharmacol 11:84. https:\/\/doi.org\/10.3389\/fphar.2020.00084","journal-title":"Front Pharmacol"},{"key":"3500_CR106","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s12031-017-1006-x","volume":"64","author":"L Huang","year":"2018","unstructured":"Huang L, Chen C, Zhang X, Li X, Chen Z, Yang C, Liang X, Zhu G, Xu Z (2018) Neuroprotective effect of curcumin against cerebral ischemia-reperfusion via mediating autophagy and inflammation. J Mol Neurosci 64:129\u2013139","journal-title":"J Mol Neurosci"},{"key":"3500_CR107","doi-asserted-by":"publisher","first-page":"15426","DOI":"10.3390\/ijms150915426","volume":"15","author":"T Luo","year":"2014","unstructured":"Luo T, Liu G, Ma H, Lu B, Xu H, Wang Y, Wu J, Ge P, Liang J (2014) Inhibition of autophagy via activation of PI3K\/Akt pathway contributes to the protection of ginsenoside Rb1 against neuronal death caused by ischemic insults. Int J Mol Sci 15:15426\u201315442. https:\/\/doi.org\/10.3390\/ijms150915426","journal-title":"Int J Mol Sci"},{"key":"3500_CR108","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20191452","author":"J Pan","year":"2019","unstructured":"Pan J, Li X, Guo F, Yang Z, Zhang L, Yang C (2019) Ginkgetin attenuates cerebral ischemia\u2013reperfusion induced autophagy and cell death via modulation of the NF-\u03baB\/p53 signaling pathway. Biosci Rep. https:\/\/doi.org\/10.1042\/BSR20191452","journal-title":"Biosci Rep"},{"key":"3500_CR109","doi-asserted-by":"publisher","first-page":"2508","DOI":"10.4049\/jimmunol.168.5.2508","volume":"168","author":"A Diab","year":"2002","unstructured":"Diab A, Deng C, Smith JD, Hussain RZ, Phanavanh B, Lovett-Racke AE, Drew PD, Racke MK (2002) Peroxisome proliferator-activated receptor-\u03b3 agonist 15-deoxy-\u039412, 1412, 14-prostaglandin J2 ameliorates experimental autoimmune encephalomyelitis. J Immunol Res 168:2508\u20132515. https:\/\/doi.org\/10.4049\/jimmunol.168.5.2508","journal-title":"J Immunol Res"},{"key":"3500_CR110","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.brainresbull.2018.05.011","volume":"140","author":"G Yang","year":"2018","unstructured":"Yang G, Wang N, Seto SW, Chang D, Liang H (2018) Hydroxysafflor yellow a protects brain microvascular endothelial cells against oxygen glucose deprivation\/reoxygenation injury: involvement of inhibiting autophagy via class I PI3K\/Akt\/mTOR signaling pathway. Brain Res Bull 140:243\u2013257. https:\/\/doi.org\/10.1016\/j.brainresbull.2018.05.011","journal-title":"Brain Res Bull"},{"key":"3500_CR111","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1002\/jnr.21890","volume":"87","author":"KM Buller","year":"2009","unstructured":"Buller KM, Carty ML, Reinebrant HE, Wixey JA (2009) Minocycline: a neuroprotective agent for hypoxic-ischemic brain injury in the neonate? J Neurosci Res 87:599\u2013608. https:\/\/doi.org\/10.1002\/jnr.21890","journal-title":"J Neurosci Res"},{"issue":"1","key":"3500_CR112","first-page":"17","volume":"2014","author":"A Majid","year":"2014","unstructured":"Majid A (2014) Neuroprotection in stroke: past, present, and future. Int Sch Res Not 2014(1):17","journal-title":"Int Sch Res Not"},{"key":"3500_CR113","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3892\/br.2015.554","volume":"4","author":"W Dong","year":"2016","unstructured":"Dong W, Xiao S, Cheng M, Ye X, Zheng G (2016) Minocycline induces protective autophagy in vascular endothelial cells exposed to an in vitro model of ischemia\/reperfusion-induced injury. Biomed Rep 4:173\u2013177. https:\/\/doi.org\/10.3892\/br.2015.554","journal-title":"Biomed Rep"},{"key":"3500_CR114","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1159\/000452172","volume":"23","author":"Y Lu","year":"2016","unstructured":"Lu Y, Xiao G, Luo W (2016) Minocycline suppresses NLRP3 inflammasome activation in experimental ischemic stroke. NeuroImmunoModulation 23:230\u2013238. https:\/\/doi.org\/10.1159\/000452172","journal-title":"NeuroImmunoModulation"},{"key":"3500_CR115","doi-asserted-by":"publisher","first-page":"791","DOI":"10.2174\/1871527319999200831153748","volume":"19","author":"S Wang","year":"2020","unstructured":"Wang S, Wang C, Wang L, Cai Z (2020) Minocycline inhibits mTOR signaling activation and alleviates behavioral deficits in the Wistar rats with acute ischemia stroke. CNS Neurol Disord Drug Targets 19:791\u2013799. https:\/\/doi.org\/10.2174\/1871527319999200831153748","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"3500_CR116","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1111\/j.1527-3458.2008.00040.x","volume":"14","author":"JP Mostert","year":"2008","unstructured":"Mostert JP, Koch MW, Heerings M, Heersema DJ, De Keyser J (2008) Therapeutic potential of fluoxetine in neurological disorders. CNS Neurosci Ther 14:153\u2013164. https:\/\/doi.org\/10.1111\/j.1527-3458.2008.00040.x","journal-title":"CNS Neurosci Ther"},{"key":"3500_CR117","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.bbr.2015.04.049","volume":"290","author":"BB McAllister","year":"2015","unstructured":"McAllister BB, Spanswick SC, Patel PP, Barneto AA, Dyck RH (2015) The effects of chronic fluoxetine treatment following injury of medial frontal cortex in mice. Behav Brain Res 290:102\u2013116. https:\/\/doi.org\/10.1016\/j.bbr.2015.04.049","journal-title":"Behav Brain Res"},{"key":"3500_CR118","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1093\/brain\/aws171","volume":"135","author":"JY Lee","year":"2012","unstructured":"Lee JY, Kim HS, Choi HY, Oh TH, Yune TY (2012) Fluoxetine inhibits matrix metalloprotease activation and prevents disruption of blood\u2013spinal cord barrier after spinal cord injury. Brain 135:2375\u20132389. https:\/\/doi.org\/10.1093\/brain\/aws171","journal-title":"Brain"},{"key":"3500_CR119","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S1474-4422(10)70314-8","volume":"10","author":"F Chollet","year":"2011","unstructured":"Chollet F, Tardy J, Albucher JF, Thalamas C, Berard E, Lamy C, Bejot Y, Deltour S, Jaillard A, Niclot P, Guillon B (2011) Fluoxetine for motor recovery after acute ischaemic stroke (FLAME): a randomised placebo-controlled trial. Lancet Neurol 10:123\u2013130. https:\/\/doi.org\/10.1016\/S1474-4422(10)70314-8","journal-title":"Lancet Neurol"},{"key":"3500_CR120","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-016-0779-0","volume":"14","author":"JR Li","year":"2017","unstructured":"Li JR, Xu HZ, Nie S, Peng YC, Fan LF, Wang ZJ, Wu C, Yan F, Chen JY, Gu C, Wang C (2017) Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subarachnoid hemorrhage in rats. J Neuroinflamm 14:1\u20134","journal-title":"J Neuroinflamm"},{"key":"3500_CR121","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-021-00258-8","author":"H Khan","year":"2021","unstructured":"Khan H, Gupta A, Singh TG, Kaur A (2021) Mechanistic insight on the role of leukotriene receptors in ischemic\u2013reperfusion injury. Pharmacol Rep. https:\/\/doi.org\/10.1007\/s43440-021-00258-8","journal-title":"Pharmacol Rep"},{"key":"3500_CR122","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/jnr.21829","volume":"87","author":"WL Li","year":"2009","unstructured":"Li WL, Cai HH, Wang B, Chen L, Zhou QG, Luo CX, Liu N, Ding XS, Zhu DY (2009) Chronic fluoxetine treatment improves ischemia-induced spatial cognitive deficits through increasing hippocampal neurogenesis after stroke. J Neurosci Res 87:112\u2013122. https:\/\/doi.org\/10.1002\/jnr.21829","journal-title":"J Neurosci Res"},{"key":"3500_CR123","doi-asserted-by":"publisher","first-page":"4638","DOI":"10.2174\/1381612822666160510125229","volume":"22","author":"L Castilla-Guerra","year":"2016","unstructured":"Castilla-Guerra L, del Carmen F-M, Angel Colmenero-Camacho M (2016) Statins in stroke prevention: present and future. Curr Pharm Des 22:4638\u20134644","journal-title":"Curr Pharm Des"},{"key":"3500_CR124","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1161\/STROKEAHA.112.668277","volume":"44","author":"D N\u00ed Chr\u00f3in\u00edn","year":"2013","unstructured":"N\u00ed Chr\u00f3in\u00edn D, Asplund K, \u00c5sberg S, Callaly E, Cuadrado-Godia E, D\u00edez-Tejedor E, Di Napoli M, Engelter ST, Furie KL, Giannopoulos S, Gotto AM Jr (2013) Statin therapy and outcome after ischemic stroke: systematic review and meta-analysis of observational studies and randomized trials. Stroke 44:448\u2013456. https:\/\/doi.org\/10.1161\/STROKEAHA.112.668277","journal-title":"Stroke"},{"key":"3500_CR125","doi-asserted-by":"publisher","first-page":"2814","DOI":"10.1161\/STROKEAHA.113.001576","volume":"44","author":"\u00c1 Merwick","year":"2013","unstructured":"Merwick \u00c1, Albers GW, Arsava EM, Ay H, Calvet D, Coutts SB, Cucchiara BL, Demchuk AM, Giles MF, Mas JL, Olivot JM (2013) Reduction in early stroke risk in carotid stenosis with transient ischemic attack associated with statin treatment. Stroke 44:2814\u20132820. https:\/\/doi.org\/10.1161\/STROKEAHA.113.001576","journal-title":"Stroke"},{"key":"3500_CR126","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/ijs.12256","volume":"9","author":"M Al-Khaled","year":"2014","unstructured":"Al-Khaled M, Matthis C, Eggers J (2014) Statin treatment in patients with acute ischemic stroke. Int J Stroke 9:597\u2013601. https:\/\/doi.org\/10.1111\/ijs.12256","journal-title":"Int J Stroke"},{"key":"3500_CR127","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1161\/STROKEAHA.111.627729","volume":"43","author":"AC Flint","year":"2012","unstructured":"Flint AC, Kamel H, Navi BB, Rao VA, Faigeles BS, Conell C, Klingman JG, Sidney S, Hills NK, Sorel M, Cullen SP (2012) Statin use during ischemic stroke hospitalization is strongly associated with improved poststroke survival. Stroke 43:147\u2013154. https:\/\/doi.org\/10.1161\/STROKEAHA.111.627729","journal-title":"Stroke"},{"key":"3500_CR128","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1002\/jnr.22633","volume":"89","author":"X Zhang","year":"2011","unstructured":"Zhang X, Deguchi S, Deguchi K, Ohta Y, Yamashita T, Shang J, Tian F, Liu N, Liu W, Ikeda Y, Matsuura T (2011) Amlodipine and atorvastatin exert protective and additive effects via antiapoptotic and antiautophagic mechanisms after transient middle cerebral artery occlusion in Zucker metabolic syndrome rats. J Neurosci Res 89:1228\u20131234. https:\/\/doi.org\/10.1002\/jnr.22633","journal-title":"J Neurosci Res"},{"key":"3500_CR129","doi-asserted-by":"publisher","first-page":"1697","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.01.033","volume":"27","author":"Y Liu","year":"2018","unstructured":"Liu Y, Yang H, Jia G, Li L, Chen H, Bi J, Wang C (2018) The synergistic neuroprotective effects of combined rosuvastatin and resveratrol pretreatment against cerebral ischemia\/reperfusion injury. J Stroke Cerebrovasc Dis 27:1697\u20131704. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2018.01.033","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"3500_CR130","doi-asserted-by":"publisher","first-page":"113117","DOI":"10.1016\/j.expneurol.2019.113117","volume":"324","author":"S Carloni","year":"2020","unstructured":"Carloni S, Balduini W (2020) Simvastatin preconditioning confers neuroprotection against hypoxia-ischemia induced brain damage in neonatal rats via autophagy and silent information regulator 1 (SIRT1) activation. Exp Neurol 324:113117. https:\/\/doi.org\/10.1016\/j.expneurol.2019.113117","journal-title":"Exp Neurol"},{"key":"3500_CR131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12035-021-02387-w","volume":"20","author":"H Khan","year":"2021","unstructured":"Khan H, Tiwari P, Kaur A, Singh TG (2021) Sirtuin acetylation and deacetylation: a complex paradigm in neurodegenerative disease. Mol Neurobiol 20:1\u20135. https:\/\/doi.org\/10.1007\/s12035-021-02387-w","journal-title":"Mol Neurobiol"},{"key":"3500_CR132","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1515\/tnsci-2015-0014","volume":"6","author":"L Wang","year":"2015","unstructured":"Wang L, Cui W, Nan G, Yu Y (2015) Meta-analysis reveals protective effects of vitamin B on stroke patients. Transl Neurosci 6:150\u2013156. https:\/\/doi.org\/10.1515\/tnsci-2015-0014","journal-title":"Transl Neurosci"},{"key":"3500_CR133","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1097\/00019052-200102000-00015","volume":"14","author":"GJ Hankey","year":"2001","unstructured":"Hankey GJ, Eikelboom JW (2001) Homocysteine and stroke. Curr Opin Neurol 14:95\u2013102","journal-title":"Curr Opin Neurol"},{"key":"3500_CR134","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1161\/01.STR.0000069017.78624.37","volume":"34","author":"G Boysen","year":"2003","unstructured":"Boysen G, Brander T, Christensen H, Gideon R, Truelsen T (2003) Homocysteine and risk of recurrent stroke. Stroke 34:1258\u20131261. https:\/\/doi.org\/10.1161\/01.STR.0000069017.78624.37","journal-title":"Stroke"},{"key":"3500_CR135","doi-asserted-by":"publisher","first-page":"e2513","DOI":"10.1126\/scitranslmed.aac9412","volume":"7","author":"M Tripathi","year":"2016","unstructured":"Tripathi M, Zhang CW, Singh BK, Sinha RA, Moe KT, DeSilva DA, Yen PM (2016) Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation. Cell Death Dis 7:e2513. https:\/\/doi.org\/10.1126\/scitranslmed.aac9412","journal-title":"Cell Death Dis"},{"key":"3500_CR136","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1016\/j.neurobiolaging.2006.05.036","volume":"28","author":"H Chen","year":"2007","unstructured":"Chen H, Tung YC, Li B, Iqbal K, Grundke-Iqbal I (2007) Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis. Neurobiol Aging 28:1148\u20131162. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2006.05.036","journal-title":"Neurobiol Aging"},{"key":"3500_CR137","doi-asserted-by":"publisher","first-page":"118401","DOI":"10.1016\/j.lfs.2020.118401","volume":"12","author":"VK Sharma","year":"2020","unstructured":"Sharma VK, Singh TG (2020) Insulin resistance and bioenergetic manifestations: targets and approaches in Alzheimer\u2019s disease. Life Sci 12:118401","journal-title":"Life Sci"},{"key":"3500_CR138","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1161\/STROKEAHA.111.628537","volume":"43","author":"WD Heiss","year":"2012","unstructured":"Heiss WD, Brainin M, Bornstein NM, Tuomilehto J, Hong Z (2012) Cerebrolysin in patients with acute ischemic stroke in Asia: results of a double-blind, placebo-controlled randomized trial. Stroke 43:630\u2013636. https:\/\/doi.org\/10.1161\/STROKEAHA.111.628537","journal-title":"Stroke"},{"key":"3500_CR139","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/978-3-7091-6467-9_26","volume-title":"Ageing and dementia","author":"M Schwab","year":"1998","unstructured":"Schwab M, Antonow-Schlorke I, Zwiener U, Bauer R (1998) Brain-derived peptides reduce the size of cerebral infarction and loss of MAP2 immunoreactivity after focal ischemia in rats. Ageing and dementia. Springer, Vienna, pp 299\u2013311. https:\/\/doi.org\/10.1007\/978-3-7091-6467-9_26"},{"key":"3500_CR140","first-page":"25","volume":"25","author":"J Ren","year":"2007","unstructured":"Ren J, Sietsma D, Qiu S, Moessler H, Finklestein SP (2007) Cerebrolysin enhances functional recovery following focal cerebral infarction in rats. Restor Neurol Neurosci 25:25\u201331","journal-title":"Restor Neurol Neurosci"},{"key":"3500_CR141","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.jns.2013.11.028","volume":"337","author":"S Xing","year":"2014","unstructured":"Xing S, Zhang J, Dang C, Liu G, Zhang Y, Li J, Fan Y, Pei Z, Zeng J (2014) Cerebrolysin reduces amyloid-\u03b2 deposits, apoptosis and autophagy in the thalamus and improves functional recovery after cortical infarction. J Neurol Sci 337:104\u2013111. https:\/\/doi.org\/10.1016\/j.jns.2013.11.028","journal-title":"J Neurol Sci"},{"key":"3500_CR142","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.2147\/NDT.S313807","volume":"17","author":"Y Ren","year":"2021","unstructured":"Ren Y, Ma X, Wang T, Cheng B, Ren L, Dong Z, Liu H (2021) The cerebroprotein hydrolysate-I plays a neuroprotective effect on cerebral ischemic stroke by inhibiting MEK\/ERK1\/2 signaling pathway in rats. Neuropsychiatr Dis Treat 17:2199. https:\/\/doi.org\/10.2147\/NDT.S313807","journal-title":"Neuropsychiatr Dis Treat"},{"key":"3500_CR143","doi-asserted-by":"publisher","first-page":"147399","DOI":"10.1016\/j.brainres.2021.147399","volume":"1761","author":"H Khan","year":"2021","unstructured":"Khan H, Singh A, Thapa K, Garg N, Grewal AK, Singh TG (2021) Therapeutic modulation of the phosphatidylinositol 3-kinases (PI3K) pathway in cerebral ischemic injury. Brain Res 1761:147399. https:\/\/doi.org\/10.1016\/j.brainres.2021.147399","journal-title":"Brain Res"},{"key":"3500_CR144","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1111\/jcmm.14691","volume":"24","author":"F Wu","year":"2020","unstructured":"Wu F, Xu K, Xu K, Teng C, Zhang M, Xia L, Zhang K, Liu L, Chen Z, Xiao J, Wu Y (2020) Dl-3n-butylphthalide improves traumatic brain injury recovery via inhibiting autophagy-induced blood-brain barrier disruption and cell apoptosis. J Cell Mol Med 24:1220\u20131232. https:\/\/doi.org\/10.1111\/jcmm.14691","journal-title":"J Cell Mol Med"},{"key":"3500_CR145","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-021-01841-7","author":"K Thapa","year":"2021","unstructured":"Thapa K, Khan H, Singh TG, Kaur A (2021) Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets. J Mol Neurosci. https:\/\/doi.org\/10.1007\/s12031-021-01841-7","journal-title":"J Mol Neurosci"},{"key":"3500_CR146","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.neuroscience.2014.01.012","volume":"263","author":"T Zhang","year":"2014","unstructured":"Zhang T, Wang H, Li Q, Huang J, Sun X (2014) Modulating autophagy affects neuroamyloidogenesis in an in vitro ischemic stroke model. Neuroscience 263:130\u2013137. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.01.012","journal-title":"Neuroscience"},{"key":"3500_CR147","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.2174\/0929867326666190308133732","volume":"27","author":"Z Wang","year":"2020","unstructured":"Wang Z, Kawabori M, Houkin K (2020) FTY720 (Fingolimod) ameliorates brain injury through multiple mechanisms and is a strong candidate for stroke treatment. Curr Med Chem 27:2979\u20132993. https:\/\/doi.org\/10.2174\/0929867326666190308133732","journal-title":"Curr Med Chem"},{"key":"3500_CR148","doi-asserted-by":"publisher","first-page":"e0188748","DOI":"10.1371\/journal.pone.0188748","volume":"12","author":"X Li","year":"2017","unstructured":"Li X, Wang MH, Qin C, Fan WH, Tian DS, Liu JL (2017) Fingolimod suppresses neuronal autophagy through the mTOR\/p70S6K pathway and alleviates ischemic brain damage in mice. PLoS ONE 12:e0188748. https:\/\/doi.org\/10.1371\/journal.pone.0188748","journal-title":"PLoS ONE"},{"key":"3500_CR149","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1159\/000490016","volume":"47","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Wu Z, Yi F, Orange M, Yao M, Yang B, Liu J, Zhu H (2018) By activating Akt\/eNOS bilobalide B inhibits autophagy and promotes angiogenesis following focal cerebral ischemia reperfusion. Cell Physiol Biochem 47:604\u2013616. https:\/\/doi.org\/10.1159\/000490016","journal-title":"Cell Physiol Biochem"},{"key":"3500_CR150","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1097\/FBP.0000000000000252","volume":"27","author":"R Wu","year":"2016","unstructured":"Wu R, Shui L, Wang S, Song Z, Tai F (2016) Bilobalide alleviates depression-like behavior and cognitive deficit induced by chronic unpredictable mild stress in mice. Behav Pharmacol 27:596\u2013605. https:\/\/doi.org\/10.1097\/FBP.0000000000000252","journal-title":"Behav Pharmacol"},{"key":"3500_CR151","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1161\/01.STR.19.4.480","volume":"19","author":"K Abe","year":"1988","unstructured":"Abe K, Yuki S, Kogure K (1988) Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke 19:480\u2013485. https:\/\/doi.org\/10.1161\/01.STR.19.4.480","journal-title":"Stroke"},{"key":"3500_CR152","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1159\/000069318","volume":"15","author":"Edaravone Acute Infarction Study Group","year":"2003","unstructured":"Edaravone Acute Infarction Study Group (2003) Effect of a novel free radical scavenger, edaravone (MCI-186), on acute brain infarction. Randomized, placebo-controlled, double-blind study at multicenters. Cerebrovasc Dis 15:222\u2013229","journal-title":"Cerebrovasc Dis"},{"key":"3500_CR153","doi-asserted-by":"publisher","first-page":"593","DOI":"10.2169\/internalmedicine.48.1871","volume":"48","author":"Y Ohta","year":"2009","unstructured":"Ohta Y, Takamatsu K, Fukushima T, Ikegami S, Takeda I, Ota T, Goto K, Abe K (2009) Efficacy of the free radical scavenger, edaravone, for motor palsy of acute lacunar infarction. Intern Med J 48:593\u2013596. https:\/\/doi.org\/10.2169\/internalmedicine.48.1871","journal-title":"Intern Med J"},{"key":"3500_CR154","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.brainres.2011.04.038","volume":"1397","author":"N Liu","year":"2011","unstructured":"Liu N, Shang J, Tian F, Nishi H, Abe K (2011) In vivo optical imaging for evaluating the efficacy of edaravone after transient cerebral ischemia in mice. Brain Res 1397:66\u201375. https:\/\/doi.org\/10.1016\/j.brainres.2011.04.038","journal-title":"Brain Res"},{"key":"3500_CR155","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4863079","author":"C Reis","year":"2017","unstructured":"Reis C, Akyol O, Ho WM, Araujo C, Huang L, Applegate R II, Zhang JH (2017) Phase I and phase II therapies for acute ischemic stroke: an update on currently studied drugs in clinical research. BioMed Res Int. https:\/\/doi.org\/10.1155\/2017\/4863079","journal-title":"BioMed Res Int"},{"key":"3500_CR156","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12929-019-0597-7","volume":"27","author":"J Modi","year":"2020","unstructured":"Modi J, Menzie-Suderam J, Xu H, Trujillo P, Medley K, Marshall ML, Tao R, Prentice H, Wu JY (2020) Mode of action of granulocyte-colony stimulating factor (G-CSF) as a novel therapy for stroke in a mouse model. J Biomed Sci 27:1\u20139","journal-title":"J Biomed Sci"},{"key":"3500_CR157","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12929-020-00692-5","volume":"27","author":"JM Menzie-Suderam","year":"2020","unstructured":"Menzie-Suderam JM, Modi J, Xu H, Bent A, Trujillo P, Medley K, Jimenez E, Shen J, Marshall M, Tao R, Prentice H (2020) Granulocyte-colony stimulating factor gene therapy as a novel therapeutics for stroke in a mouse model. J Biomed Sci 27:1\u201322","journal-title":"J Biomed Sci"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-021-03500-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-021-03500-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-021-03500-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T02:09:50Z","timestamp":1646273390000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-021-03500-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,7]]},"references-count":157,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["3500"],"URL":"https:\/\/doi.org\/10.1007\/s11064-021-03500-0","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,7]]},"assertion":[{"value":"23 August 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"There are no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}}]}}