{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:37:37Z","timestamp":1778906257467,"version":"3.51.4"},"reference-count":60,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["R01ES10563"],"award-info":[{"award-number":["R01ES10563"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012434","name":"Middle-aged and Young Teachers' Basic Ability Promotion Project of Guangxi","doi-asserted-by":"publisher","award":["2018KY288"],"award-info":[{"award-number":["2018KY288"]}],"id":[{"id":"10.13039\/501100012434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 81973094"],"award-info":[{"award-number":["NSFC 81973094"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s11064-022-03606-z","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T18:04:28Z","timestamp":1651773868000},"page":"2198-2210","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Methylcyclopentadienyl Manganese Tricarbonyl Alter Behavior and Cause Ultrastructural Changes in the Substantia Nigra of Rats: Comparison with Inorganic Manganese Chloride"],"prefix":"10.1007","volume":"47","author":[{"given":"Qi-feng","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-li","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-yuan","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-ying","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-wei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-xiao","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Aschner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ce","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-ming","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"issue":"28","key":"3606_CR1","doi-asserted-by":"publisher","first-page":"29257","DOI":"10.1007\/s11356-019-06112-y","volume":"26","author":"S Biswas","year":"2019","unstructured":"Biswas S, Anjum A, Banna HU, Rahman M, Siddique AE, Karim Y, Nikkon F, Haque A, Hossain K, Saud ZA (2019) Manganese attenuates the effects of arsenic on neurobehavioral and biochemical changes in mice co-exposed to arsenic and manganese. Environ Sci Pollut Res Int 26(28):29257\u201329266. https:\/\/doi.org\/10.1007\/s11356-019-06112-y","journal-title":"Environ Sci Pollut Res Int"},{"key":"3606_CR2","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.neuro.2016.09.017","volume":"58","author":"D McGough","year":"2017","unstructured":"McGough D, Jardine L (2017) A two-generation inhalation reproductive toxicity study upon the exposure to manganese chloride. Neurotoxicology 58:194\u2013202. https:\/\/doi.org\/10.1016\/j.neuro.2016.09.017","journal-title":"Neurotoxicology"},{"issue":"2","key":"3606_CR3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.taap.2004.02.010","volume":"197","author":"DC Dorman","year":"2004","unstructured":"Dorman DC, McManus BE, Marshall MW, James RA, Struve MF (2004) Old age and gender influence the pharmacokinetics of inhaled manganese sulfate and manganese phosphate in rats. Toxicol Appl Pharmacol 197(2):113\u2013124. https:\/\/doi.org\/10.1016\/j.taap.2004.02.010","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"3606_CR4","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1093\/toxsci\/kfv099","volume":"146","author":"TR Guilarte","year":"2015","unstructured":"Guilarte TR, Gonzales KK (2015) Manganese-induced Parkinsonism is not idiopathic Parkinson\u2019s disease: environmental and genetic evidence. Toxicol Sci 146(2):204\u2013212. https:\/\/doi.org\/10.1093\/toxsci\/kfv099","journal-title":"Toxicol Sci"},{"issue":"2","key":"3606_CR5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.taap.2007.03.001","volume":"221","author":"M Aschner","year":"2007","unstructured":"Aschner M, Guilarte TR, Schneider JS, Zheng W (2007) Manganese: recent advances in understanding its transport and neurotoxicity. Toxicol Appl Pharmacol 221(2):131\u2013147. https:\/\/doi.org\/10.1016\/j.taap.2007.03.001","journal-title":"Toxicol Appl Pharmacol"},{"issue":"4","key":"3606_CR6","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1111\/jnc.13442","volume":"136","author":"S Bouabid","year":"2016","unstructured":"Bouabid S, Tinakoua A, Lakhdar-Ghazal N, Benazzouz A (2016) Manganese neurotoxicity: behavioral disorders associated with dysfunctions in the basal ganglia and neurochemical transmission. J Neurochem 136(4):677\u2013691. https:\/\/doi.org\/10.1111\/jnc.13442","journal-title":"J Neurochem"},{"issue":"6","key":"3606_CR7","doi-asserted-by":"publisher","first-page":"e98952","DOI":"10.1371\/journal.pone.0098952","volume":"9","author":"S Bouabid","year":"2014","unstructured":"Bouabid S, Delaville C, De Deurwaerd\u00e8re P, Lakhdar-Ghazal N, Benazzouz A (2014) Manganese-induced atypical parkinsonism is associated with altered Basal Ganglia activity and changes in tissue levels of monoamines in the rat. PLoS ONE 9(6):e98952. https:\/\/doi.org\/10.1371\/journal.pone.0098952","journal-title":"PLoS ONE"},{"issue":"17","key":"3606_CR8","doi-asserted-by":"publisher","first-page":"5981","DOI":"10.3390\/ijms21175981","volume":"21","author":"O Wasel","year":"2020","unstructured":"Wasel O, Freeman JL (2020) Chemical and genetic Zebrafish models to define mechanisms of and treatments for dopaminergic neurodegeneration. Int J Mol Sci 21(17):5981. https:\/\/doi.org\/10.3390\/ijms21175981","journal-title":"Int J Mol Sci"},{"key":"3606_CR9","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.neuro.2016.09.001","volume":"58","author":"DR Mattison","year":"2017","unstructured":"Mattison DR, Milton B, Krewski D, Levy L, Dorman DC, Aggett PJ, Roels HA, Andersen ME, Karyakina NA, Shilnikova N, Ramoju S, McGough D (2017) Severity scoring of manganese health effects for categorical regression. Neurotoxicology 58:203\u2013216. https:\/\/doi.org\/10.1016\/j.neuro.2016.09.001","journal-title":"Neurotoxicology"},{"issue":"1","key":"3606_CR10","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1093\/toxsci\/kfn213","volume":"107","author":"F Zhao","year":"2009","unstructured":"Zhao F, Cai T, Liu M, Zheng G, Luo W, Chen J (2009) Manganese induces dopaminergic neurodegeneration via microglial activation in a rat model of manganism. Toxicol Sci 107(1):156\u2013164. https:\/\/doi.org\/10.1093\/toxsci\/kfn213","journal-title":"Toxicol Sci"},{"issue":"10","key":"3606_CR11","doi-asserted-by":"publisher","first-page":"6745","DOI":"10.1007\/s12035-015-9602-7","volume":"53","author":"Q Song","year":"2016","unstructured":"Song Q, Deng Y, Yang X, Bai Y, Xu B, Liu W, Zheng W, Wang C, Zhang M, Xu Z (2016) Manganese-disrupted interaction of dopamine D1 and NMDAR in the striatum to injury learning and memory ability of mice. Mol Neurobiol 53(10):6745\u20136758. https:\/\/doi.org\/10.1007\/s12035-015-9602-7","journal-title":"Mol Neurobiol"},{"issue":"6","key":"3606_CR12","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1016\/j.neuro.2007.06.005","volume":"28","author":"TR Guilarte","year":"2007","unstructured":"Guilarte TR, Chen MK (2007) Manganese inhibits NMDA receptor channel function: implications to psychiatric and cognitive effects. Neurotoxicology 28(6):1147\u20131152. https:\/\/doi.org\/10.1016\/j.neuro.2007.06.005","journal-title":"Neurotoxicology"},{"issue":"50","key":"3606_CR13","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.neuro.2015.07.005","volume":"2015","author":"TV Peres","year":"2015","unstructured":"Peres TV, Eyng H, Lopes SC, Colle D, Gon\u00e7alves FM, Venske DK, Lopes MW, Ben J, Bornhorst J, Schwerdtle T, Aschner M, Farina M, Prediger RD, Leal RB (2015) Developmental exposure to manganese induces lasting motor and cognitive impairment in rats. Neurotoxicology 2015(50):28\u201337. https:\/\/doi.org\/10.1016\/j.neuro.2015.07.005","journal-title":"Neurotoxicology"},{"issue":"1","key":"3606_CR14","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.tox.2013.09.008","volume":"314","author":"D Santos","year":"2013","unstructured":"Santos D, Bator\u00e9u MC, Tavares de Almeida I, Davis Randall L, Mateus ML, Andrade V, Ramos R, Torres E, Aschner M, Marreilha dos Santos AP (2013) Evaluation of neurobehavioral and neuroinflammatory end-points in the post-exposure period in rats sub-acutely exposed to manganese. Toxicology 314(1):95\u201399. https:\/\/doi.org\/10.1016\/j.tox.2013.09.008","journal-title":"Toxicology"},{"issue":"6","key":"3606_CR15","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","volume":"140","author":"CK Glass","year":"2010","unstructured":"Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140(6):918\u2013934. https:\/\/doi.org\/10.1016\/j.cell.2010.02.016","journal-title":"Cell"},{"issue":"4","key":"3606_CR16","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/S1474-4422(09)70062-6","volume":"8","author":"EC Hirsch","year":"2009","unstructured":"Hirsch EC, Hunot S (2009) Neuroinflammation in Parkinson\u2019s disease: a target for neuroprotection? Lancet Neurol 8(4):382\u2013397. https:\/\/doi.org\/10.1016\/S1474-4422(09)70062-6","journal-title":"Lancet Neurol"},{"issue":"2","key":"3606_CR17","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.neuro.2010.11.003","volume":"32","author":"T Verina","year":"2011","unstructured":"Verina T, Kiihl SF, Schneider JS, Guilarte TR (2011) Manganese exposure induces microglia activation and dystrophy in the substantia nigra of non-human primates. Neurotoxicology 32(2):215\u2013226. https:\/\/doi.org\/10.1016\/j.neuro.2010.11.003","journal-title":"Neurotoxicology"},{"issue":"2","key":"3606_CR18","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1093\/toxsci\/kfm044","volume":"97","author":"KM Erikson","year":"2007","unstructured":"Erikson KM, Dorman DC, Lash LH, Aschner M (2007) Manganese inhalation by rhesus monkeys is associated with brain regional changes in biomarkers of neurotoxicity. Toxicol Sci 97(2):459\u2013466. https:\/\/doi.org\/10.1093\/toxsci\/kfm044","journal-title":"Toxicol Sci"},{"issue":"1","key":"3606_CR19","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/j.1471-4159.2009.06145.x","volume":"110","author":"GD Stanwood","year":"2009","unstructured":"Stanwood GD, Leitch DB, Savchenko V, Wu J, Fitsanakis VA, Anderson DJ, Stankowski JN, Aschner M, McLaughlin B (2009) Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia. J Neurochem 110(1):378\u2013389. https:\/\/doi.org\/10.1111\/j.1471-4159.2009.06145.x","journal-title":"J Neurochem"},{"issue":"7\u20138","key":"3606_CR20","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/s0899-9007(01)00546-9","volume":"17","author":"RN Dickerson","year":"2001","unstructured":"Dickerson RN (2001) Manganese intoxication and parenteral nutrition. Nutrition 17(7\u20138):689\u2013693. https:\/\/doi.org\/10.1016\/s0899-9007(01)00546-9","journal-title":"Nutrition"},{"issue":"6","key":"3606_CR21","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1177\/0148607199023006333","volume":"23","author":"K Fitzgerald","year":"1999","unstructured":"Fitzgerald K, Mikalunas V, Rubin H, McCarthey R, Vanagunas A, Craig RM (1999) Hypermanganesemia in patients receiving total parenteral nutrition. JPEN J Parenter Enteral Nutr 23(6):333\u2013336. https:\/\/doi.org\/10.1177\/0148607199023006333","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"4","key":"3606_CR22","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1177\/0148607100024004223","volume":"24","author":"DB Bertinet","year":"2000","unstructured":"Bertinet DB, Tinivella M, Balzola FA, de Francesco A, Davini O, Rizzo L, Massarenti P, Leonardi MA, Balzola F (2000) Brain manganese deposition and blood levels in patients undergoing home parenteral nutrition. JPEN J Parenter Enteral Nutr 24(4):223\u2013227. https:\/\/doi.org\/10.1177\/0148607100024004223","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"1","key":"3606_CR23","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/0378-4274(94)90189-9","volume":"73","author":"J Komura","year":"1994","unstructured":"Komura J, Sakamoto M (1994) Chronic oral administration of methylcyclopentadienyl manganese tricarbonyl altered brain biogenic amines in the mouse: comparison with inorganic manganese. Toxicol Lett 73(1):65\u201373. https:\/\/doi.org\/10.1016\/0378-4274(94)90189-9","journal-title":"Toxicol Lett"},{"issue":"3","key":"3606_CR24","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1006\/enrs.1999.4026","volume":"82","author":"SH Liu","year":"2000","unstructured":"Liu SH, Wang JH, Kang JJ, Lin RH, Lin-Shiau SY (2000) Alterations in the properties and isoforms of sciatic nerve Na(+), K(+)-ATPase in methylcyclopentadienyl manganese tricarbonyl-treated mice. Environ Res 82(3):239\u2013244. https:\/\/doi.org\/10.1006\/enrs.1999.4026","journal-title":"Environ Res"},{"key":"3606_CR25","unstructured":"Howe PD, Malcolm HM, Dobson S (2004) Manganese and its compounds: environmental aspects. World Health Organization & International Programme on Chemical Safety 17(1)"},{"issue":"1","key":"3606_CR26","first-page":"47","volume":"74","author":"F Yang","year":"1999","unstructured":"Yang F, Chau YK (1999) Determination of methylcyclopentadienyl-manganese tricarbonyl (MMT) in aqueous samples by SPME-GC-AED. Talanta 74(1):47\u201351","journal-title":"Talanta"},{"issue":"2","key":"3606_CR27","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1080\/01480545.2018.1424180","volume":"42","author":"N Kamemura","year":"2019","unstructured":"Kamemura N (2019) Methylcyclopentadienyl manganese tricarbonyl increases cell vulnerability to oxidative stress on rat thymocytes. Drug Chem Toxicol 42(2):140\u2013146. https:\/\/doi.org\/10.1080\/01480545.2018.1424180","journal-title":"Drug Chem Toxicol"},{"issue":"2","key":"3606_CR28","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1177\/0748233715616554","volume":"33","author":"B Xia","year":"2017","unstructured":"Xia B, Chen K, Lv Y, Huang D, Liu J, Liang G, Zhang L, Wang F, Su C, Zou Y, Yang X (2017) Increased oxidative stress and plasma Hsp70 levels among gasoline filling station attendants. Toxicol Ind Health 33(2):171\u2013181. https:\/\/doi.org\/10.1177\/0748233715616554","journal-title":"Toxicol Ind Health"},{"key":"3606_CR29","doi-asserted-by":"publisher","first-page":"261.e3","DOI":"10.1016\/j.ajem.2020.08.087","volume":"42","author":"A Nemanich","year":"2021","unstructured":"Nemanich A, Chen B, Valento M (2021) Toxic boost: acute, reversible neurotoxicity after ingestion of methylcyclopentadienyl manganese tricarbonyl (MMT) mistaken for an energy drink. Am J Emerg Med 42:261.e3-261.e5. https:\/\/doi.org\/10.1016\/j.ajem.2020.08.087","journal-title":"Am J Emerg Med"},{"issue":"4","key":"3606_CR30","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/BF00203812","volume":"23","author":"J Komura","year":"1992","unstructured":"Komura J, Sakamoto M (1992) Disposition, behavior, and toxicity of methylcyclopentadienyl manganese tricarbonyl in the mouse. Arch Environ Contam Toxicol 23(4):473\u2013475. https:\/\/doi.org\/10.1007\/BF00203812","journal-title":"Arch Environ Contam Toxicol"},{"issue":"11","key":"3606_CR31","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1002\/tox.22161","volume":"31","author":"C Su","year":"2016","unstructured":"Su C, Chen K, Zou Y, Shen Y, Xia B, Liang G, Lv Y, Wang F, Huang D, Yang X (2016) Chronic exposure to manganese sulfate leads to adverse dose-dependent effects on the neurobehavioral ability of rats. Environ Toxicol 31(11):1571\u20131579. https:\/\/doi.org\/10.1002\/tox.22161","journal-title":"Environ Toxicol"},{"issue":"6","key":"3606_CR32","first-page":"S106","volume":"20","author":"A Joly","year":"2011","unstructured":"Joly A, Lambert J, Gagnon C (2011) Reduced atmospheric manganese in montreal following removal of methylcyclopentadienyl manganese tricarbonyl (MMT). J Toxicol Environ Health 20(6):S106\u2013S107","journal-title":"J Toxicol Environ Health"},{"issue":"4","key":"3606_CR33","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1039\/c4mt00012a","volume":"6","author":"A Carmona","year":"2014","unstructured":"Carmona A, Roudeau S, Perrin L, Veronesi G, Ortega R (2014) Environmental manganese compounds accumulate as Mn(II) within the Golgi apparatus of dopamine cells: relationship between speciation, subcellular distribution, and cytotoxicity. Metallomics 6(4):822\u2013832. https:\/\/doi.org\/10.1039\/c4mt00012a","journal-title":"Metallomics"},{"issue":"3","key":"3606_CR34","first-page":"75","volume":"3","author":"G Gianutsos","year":"1982","unstructured":"Gianutsos G, Murray MT (1982) Alterations in brain dopamine and GABA following inorganic or organic manganese administration. Neurotoxicology 3(3):75\u201381","journal-title":"Neurotoxicology"},{"issue":"5","key":"3606_CR35","doi-asserted-by":"publisher","first-page":"1738","DOI":"10.1523\/JNEUROSCI.22-05-01738.2002","volume":"22","author":"V Anantharam","year":"2002","unstructured":"Anantharam V, Kitazawa M, Wagner J, Kaul S, Kanthasamy AG (2002) Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. J Neurosci 22(5):1738\u20131751. https:\/\/doi.org\/10.1523\/JNEUROSCI.22-05-01738.2002","journal-title":"J Neurosci"},{"key":"3606_CR36","doi-asserted-by":"publisher","first-page":"81","DOI":"10.2307\/3428714","volume":"25","author":"K Kostial","year":"1978","unstructured":"Kostial K, Kello D, Jugo S, Rabar I, Maljkovic T (1978) Influence of age on metal metabolism and toxicity. Environ Health Perspect 25:81\u201386. https:\/\/doi.org\/10.2307\/3428714","journal-title":"Environ Health Perspect"},{"issue":"3","key":"3606_CR37","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/0041-008x(80)90068-x","volume":"56","author":"RP Hanzlik","year":"1980","unstructured":"Hanzlik RP, Stitt R, Traiger GJ (1980) Toxic effects of methylcyclopentadienyl manganese tricarbonyl (MMT) in rats: role of metabolism. Toxicol Appl Pharmacol 56(3):353\u2013360. https:\/\/doi.org\/10.1016\/0041-008x(80)90068-x","journal-title":"Toxicol Appl Pharmacol"},{"issue":"2","key":"3606_CR38","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/0165-0270(90)90154-8","volume":"31","author":"LB Goldstein","year":"1990","unstructured":"Goldstein LB, Davis JN (1990) Beam-walking in rats: studies towards developing an animal model of functional recovery after brain injury. J Neurosci Methods 31(2):101\u2013107. https:\/\/doi.org\/10.1016\/0165-0270(90)90154-8","journal-title":"J Neurosci Methods"},{"key":"3606_CR39","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-021-02874-0","author":"LL Lu","year":"2021","unstructured":"Lu LL, Zhang YW, Li ZC, Fang YY, Wang LL, Zhao YS, Li SJ, Ou SY, Aschner M, Jiang YM (2021) Therapeutic effects of sodium para-aminosalicylic acid on cognitive deficits and activated ERK1\/2-p90RSK\/NF-\u03baB inflammatory pathway in Pb-exposed rats. Biol Trace Elem Res. https:\/\/doi.org\/10.1007\/s12011-021-02874-0","journal-title":"Biol Trace Elem Res"},{"issue":"2","key":"3606_CR40","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1007\/s12011-019-02001-0","volume":"197","author":"ZC Li","year":"2020","unstructured":"Li ZC, Wang F, Li SJ, Zhao L, Li JY, Deng Y, Zhu XJ, Zhang YW, Peng DJ, Jiang YM (2020) Sodium para-aminosalicylic acid reverses changes of glutamate turnover in manganese-exposed rats. Biol Trace Elem Res 197(2):544\u2013554. https:\/\/doi.org\/10.1007\/s12011-019-02001-0","journal-title":"Biol Trace Elem Res"},{"issue":"3","key":"3606_CR41","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1177\/0960327114529454","volume":"34","author":"SJ Li","year":"2015","unstructured":"Li SJ, Meng HY, Deng XF, Fu X, Chen JW, Huang S, Huang YS, Luo HL, Ou SY, Jiang YM (2015) Protective effects of sodium p-aminosalicylic acid on learning and memory via increasing the number of basal forebrain choline acetyltransferase neurons in manganese-exposed rats. Hum Exp Toxicol 34(3):240\u2013248. https:\/\/doi.org\/10.1177\/0960327114529454","journal-title":"Hum Exp Toxicol"},{"issue":"10","key":"3606_CR42","doi-asserted-by":"publisher","first-page":"e01804","DOI":"10.1002\/brb3.1804","volume":"10","author":"L Huang","year":"2020","unstructured":"Huang L, Wan Y, Dang Z, Yang P, Yang Q, Wu S (2020) Hypoxic preconditioning ameliorated neuronal injury after middle cerebral artery occlusion by promoting neurogenesis. Brain Behav 10(10):e01804. https:\/\/doi.org\/10.1002\/brb3.1804","journal-title":"Brain Behav"},{"issue":"1","key":"3606_CR43","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.expneurol.2009.02.013","volume":"217","author":"P Zhang","year":"2009","unstructured":"Zhang P, Wong TA, Lokuta KM, Turner DE, Vujisic K, Liu B (2009) Microglia enhance manganese chloride-induced dopaminergic neurodegeneration: role of free radical generation. Exp Neurol 217(1):219\u2013230. https:\/\/doi.org\/10.1016\/j.expneurol.2009.02.013","journal-title":"Exp Neurol"},{"key":"3606_CR44","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jtemb.2019.04.013","volume":"54","author":"DJ Peng","year":"2019","unstructured":"Peng DJ, Zhang YW, Li ZC, Li SJ, Cai M, Qin WX, Ou SY, Huang XW, Yuan ZX, Jiang YM (2019) Preventive impacts of PAS-Na on the slow growth and activated inflammatory responses in Mn-exposed rats. J Trace Elem Med Biol 54:134\u2013141. https:\/\/doi.org\/10.1016\/j.jtemb.2019.04.013","journal-title":"J Trace Elem Med Biol"},{"issue":"6","key":"3606_CR45","first-page":"711","volume":"8","author":"JP Nachtman","year":"1986","unstructured":"Nachtman JP, Tubben RE, Commissaris RL (1986) Behavioral effects of chronic manganese administration in rats: locomotor activity studies. Neurobehav Toxicol Teratol 8(6):711\u2013715","journal-title":"Neurobehav Toxicol Teratol"},{"key":"3606_CR46","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.tox.2018.08.006","volume":"410","author":"Y Tian","year":"2018","unstructured":"Tian Y, Chen C, Guo S, Zhao L, Yan Y (2018) Exploration of the establishment of manganese poisoning rat model and analysis of discriminant methods. Toxicology 410:193\u2013198. https:\/\/doi.org\/10.1016\/j.tox.2018.08.006","journal-title":"Toxicology"},{"issue":"1","key":"3606_CR47","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.pbb.2005.03.011","volume":"81","author":"AJ Williams","year":"2005","unstructured":"Williams AJ, Myers TM, Cohn SI, Sharrow KM, Lu XC, Tortella FC (2005) Recovery from ischemic brain injury in the rat following a 10 h delayed injection with MLN519. Pharmacol Biochem Behav 81(1):182\u2013189. https:\/\/doi.org\/10.1016\/j.pbb.2005.03.011","journal-title":"Pharmacol Biochem Behav"},{"key":"3606_CR48","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.3791\/2376","volume":"49","author":"TN Luong","year":"2011","unstructured":"Luong TN, Carlisle HJ, Southwell A, Patterson PH (2011) Assessment of motor balance and coordination in mice using the balance beam. J Vis Exp 49:2376. https:\/\/doi.org\/10.3791\/2376","journal-title":"J Vis Exp"},{"key":"3606_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.117151","volume":"287","author":"G Fasano","year":"2021","unstructured":"Fasano G, Godoy RS, Angiulli E, Consalvo A, Franco C, Mancini M, Santucci D, Alleva E, Ciavardelli D, Toni M, Biffali E, Ekker M, Canzoniero L, Sordino P (2021) Effects of low-dose methylcyclopentadienyl manganese tricarbonyl-derived manganese on the development of diencephalic dopaminergic neurons in zebrafish. Environ Pollut 287:117151. https:\/\/doi.org\/10.1016\/j.envpol.2021.117151","journal-title":"Environ Pollut"},{"issue":"4","key":"3606_CR50","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s12017-009-8083-0","volume":"11","author":"M Aschner","year":"2009","unstructured":"Aschner M, Erikson KM, Herrero Hern\u00e1ndez E, Tjalkens R (2009) Manganese and its role in Parkinson\u2019s disease: from transport to neuropathology. Neuromol Med 11(4):252\u2013266. https:\/\/doi.org\/10.1007\/s12017-009-8083-0","journal-title":"Neuromol Med"},{"issue":"4","key":"3606_CR51","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.jtemb.2011.08.144","volume":"25","author":"AB Bowman","year":"2011","unstructured":"Bowman AB, Kwakye GF, Herrero Hern\u00e1ndez E, Aschner M (2011) Role of manganese in neurodegenerative diseases. J Trace Elem Med Biol 25(4):191\u2013203. https:\/\/doi.org\/10.1016\/j.jtemb.2011.08.144","journal-title":"J Trace Elem Med Biol"},{"issue":"1","key":"3606_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuro.2010.10.002","volume":"32","author":"W Zheng","year":"2011","unstructured":"Zheng W, Fu SX, Dydak U, Cowan DM (2011) Biomarkers of manganese intoxication. Neurotoxicology 32(1):1\u20138. https:\/\/doi.org\/10.1016\/j.neuro.2010.10.002","journal-title":"Neurotoxicology"},{"issue":"2\u20133","key":"3606_CR53","first-page":"173","volume":"20","author":"M Aschner","year":"1999","unstructured":"Aschner M, Vrana KE, Zheng W (1999) Manganese uptake and distribution in the central nervous system (CNS). Neurotoxicology 20(2\u20133):173\u2013180","journal-title":"Neurotoxicology"},{"issue":"2\u20133","key":"3606_CR54","first-page":"227","volume":"20","author":"PK Pal","year":"1999","unstructured":"Pal PK, Samii A, Calne DB (1999) Manganese neurotoxicity: a review of clinical features, imaging and pathology. Neurotoxicology 20(2\u20133):227\u2013238","journal-title":"Neurotoxicology"},{"issue":"2","key":"3606_CR55","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3109\/03602537609029977","volume":"5","author":"CD Klaassen","year":"1976","unstructured":"Klaassen CD (1976) Biliary excretion of metals. Drug Metab Rev 5(2):165\u2013196. https:\/\/doi.org\/10.3109\/03602537609029977","journal-title":"Drug Metab Rev"},{"issue":"5","key":"3606_CR56","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1039\/c5mt00023h","volume":"7","author":"G Robison","year":"2015","unstructured":"Robison G, Sullivan B, Cannon JR, Pushkar Y (2015) Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation. Metallomics 7(5):748\u2013755. https:\/\/doi.org\/10.1039\/c5mt00023h","journal-title":"Metallomics"},{"issue":"1","key":"3606_CR57","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3892\/mmr.2019.10825","volume":"21","author":"Q Wu","year":"2020","unstructured":"Wu Q, Zhang H, Nie H, Zeng Z (2020) Anti-Nogo-A antibody promotes brain function recovery after cardiopulmonary resuscitation in rats by reducing apoptosis. Mol Med Rep 21(1):77\u201388. https:\/\/doi.org\/10.3892\/mmr.2019.10825","journal-title":"Mol Med Rep"},{"key":"3606_CR58","doi-asserted-by":"publisher","first-page":"175","DOI":"10.3389\/fnins.2013.00175","volume":"7","author":"M Baudonnat","year":"2013","unstructured":"Baudonnat M, Huber A, David V, Walton ME (2013) Heads for learning, tails for memory: reward, reinforcement and a role of dopamine in determining behavioral relevance across multiple timescales. Front Neurosci 7:175. https:\/\/doi.org\/10.3389\/fnins.2013.00175","journal-title":"Front Neurosci"},{"key":"3606_CR59","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.neuro.2015.04.004","volume":"48","author":"JS Schneider","year":"2015","unstructured":"Schneider JS, Williams C, Ault M, Guilarte TR (2015) Effects of chronic manganese exposure on attention and working memory in non-human primates. Neurotoxicology 48:217\u2013222. https:\/\/doi.org\/10.1016\/j.neuro.2015.04.004","journal-title":"Neurotoxicology"},{"issue":"1","key":"3606_CR60","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1007\/s12640-009-9045-x","volume":"16","author":"M Liu","year":"2009","unstructured":"Liu M, Cai T, Zhao F, Zheng G, Wang Q, Chen Y, Huang C, Luo W, Chen J (2009) Effect of microglia activation on dopaminergic neuronal injury induced by manganese, and its possible mechanism. Neurotox Res 16(1):42\u201349. https:\/\/doi.org\/10.1007\/s12640-009-9045-x","journal-title":"Neurotox Res"}],"updated-by":[{"DOI":"10.1007\/s11064-025-04371-5","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T00:00:00Z","timestamp":1743206400000}}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-022-03606-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-022-03606-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-022-03606-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T06:14:05Z","timestamp":1659593645000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-022-03606-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,5]]},"references-count":60,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["3606"],"URL":"https:\/\/doi.org\/10.1007\/s11064-022-03606-z","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,5]]},"assertion":[{"value":"22 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal procedures performed in this study were performed strictly according to the international standards of animal care guidelines and have been approved by the Animal Care and Use Committee of Guangxi Medical University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The paper has been approved by all authors for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publish"}}]}}