{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:29:22Z","timestamp":1772119762740,"version":"3.50.1"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s11064-022-03618-9","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T10:03:01Z","timestamp":1652176981000},"page":"2307-2316","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Micronized Curcumin Causes Hyperlocomotion in Zebrafish Larvae"],"prefix":"10.1007","volume":"47","author":[{"given":"Adrieli","family":"Sachett","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Radharani","family":"Benvenutti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos G.","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus","family":"Gallas-Lopes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo M.","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gean P. S.","family":"Aguiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana P.","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Vladimir","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Siebel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5109-7306","authenticated-orcid":false,"given":"Angelo","family":"Piato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"3618_CR1","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1038\/nrd4627","volume":"14","author":"CA MacRae","year":"2015","unstructured":"MacRae CA, Peterson RT (2015) Zebrafish as tools for drug discovery. Nat Rev Drug Discov 14:721\u2013731. https:\/\/doi.org\/10.1038\/nrd4627","journal-title":"Nat Rev Drug Discov"},{"key":"3618_CR2","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.4957","volume":"6","author":"R Benvenutti","year":"2018","unstructured":"Benvenutti R, Marcon M, Reis CG et al (2018) N-acetylcysteine protects against motor, optomotor and morphological deficits induced by 6-OHDA in zebrafish larvae. PeerJ 6:e4957. https:\/\/doi.org\/10.7717\/peerj.4957","journal-title":"PeerJ"},{"key":"3618_CR3","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24948","author":"R Benvenutti","year":"2021","unstructured":"Benvenutti R, Gallas-Lopes M, Sachett A et al (2021) How do zebrafish (Danio rerio) respond to MK-801 and amphetamine? Relevance for assessing schizophrenia-related endophenotypes in alternative model organisms. J Neurosci Res. https:\/\/doi.org\/10.1002\/jnr.24948","journal-title":"J Neurosci Res"},{"key":"3618_CR4","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X19666210215121428","author":"R Benvenutti","year":"2021","unstructured":"Benvenutti R, Gallas-Lopes M, Marcon M et al (2021) Glutamate Nmda receptor antagonists with relevance to schizophrenia: a review of zebrafish behavioral studies. Curr Neuropharmacol. https:\/\/doi.org\/10.2174\/1570159X19666210215121428","journal-title":"Curr Neuropharmacol"},{"key":"3618_CR5","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1038\/s41598-018-20897-x","volume":"8","author":"KT Bertoncello","year":"2018","unstructured":"Bertoncello KT, Aguiar GPS, Oliveira JV, Siebel AM (2018) Micronization potentiates curcumin\u2019s anti-seizure effect and brings an important advance in epilepsy treatment. Sci Rep 8:2645. https:\/\/doi.org\/10.1038\/s41598-018-20897-x","journal-title":"Sci Rep"},{"key":"3618_CR6","doi-asserted-by":"publisher","DOI":"10.1039\/c5mt00267b","author":"J Lee","year":"2016","unstructured":"Lee J, Freeman J (2016) Embryonic exposure to 10 \u03bcg L(-1) lead results in female-specific expression changes in genes associated with nervous system development and function and Alzheimer\u2019s disease in aged adult zebrafish brain. Met Integr Biometal Sci. https:\/\/doi.org\/10.1039\/c5mt00267b","journal-title":"Met Integr Biometal Sci"},{"key":"3618_CR7","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.pnpbp.2019.03.014","volume":"93","author":"R Mocelin","year":"2019","unstructured":"Mocelin R, Marcon M, da Rosa Araujo AS et al (2019) Withdrawal effects following repeated ethanol exposure are prevented by N-acetylcysteine in zebrafish. Prog Neuropsychopharmacol Biol Psychiatry 93:161\u2013170. https:\/\/doi.org\/10.1016\/j.pnpbp.2019.03.014","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3618_CR8","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/s41573-021-00210-8","volume":"20","author":"EE Patton","year":"2021","unstructured":"Patton EE, Zon LI, Langenau DM (2021) Zebrafish disease models in drug discovery: from preclinical modelling to clinical trials. Nat Rev Drug Discov 20:611\u2013628. https:\/\/doi.org\/10.1038\/s41573-021-00210-8","journal-title":"Nat Rev Drug Discov"},{"key":"3618_CR9","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/j.pnpbp.2010.12.018","volume":"35","author":"\u00c2L Piato","year":"2011","unstructured":"Piato \u00c2L, Capiotti KM, Tamborski AR et al (2011) Unpredictable chronic stress model in zebrafish (Danio rerio): behavioral and physiological responses. Prog Neuropsychopharmacol Biol Psychiatry 35:561\u2013567. https:\/\/doi.org\/10.1016\/j.pnpbp.2010.12.018","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3618_CR10","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1089\/zeb.2012.0785","volume":"10","author":"MT Akhtar","year":"2013","unstructured":"Akhtar MT, Ali S, Rashidi H et al (2013) Developmental effects of cannabinoids on zebrafish larvae. Zebrafish 10:283\u2013293. https:\/\/doi.org\/10.1089\/zeb.2012.0785","journal-title":"Zebrafish"},{"key":"3618_CR11","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.ntt.2009.04.066","volume":"32","author":"TD Irons","year":"2010","unstructured":"Irons TD, MacPhail RC, Hunter DL, Padilla S (2010) Acute neuroactive drug exposures alter locomotor activity in larval zebrafish. Neurotoxicol Teratol 32:84\u201390. https:\/\/doi.org\/10.1016\/j.ntt.2009.04.066","journal-title":"Neurotoxicol Teratol"},{"key":"3618_CR12","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.pbb.2012.12.010","volume":"103","author":"TD Irons","year":"2013","unstructured":"Irons TD, Kelly PE, Hunter DL et al (2013) Acute administration of dopaminergic drugs has differential effects on locomotion in larval zebrafish. Pharmacol Biochem Behav 103:792\u2013813. https:\/\/doi.org\/10.1016\/j.pbb.2012.12.010","journal-title":"Pharmacol Biochem Behav"},{"key":"3618_CR13","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1089\/zeb.2006.9994","volume":"4","author":"B Parker","year":"2007","unstructured":"Parker B, Connaughton VP (2007) Effects of nicotine on growth and development in larval zebrafish. Zebrafish 4:59\u201368. https:\/\/doi.org\/10.1089\/zeb.2006.9994","journal-title":"Zebrafish"},{"key":"3618_CR14","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1021\/es404322p","volume":"48","author":"TD Raftery","year":"2014","unstructured":"Raftery TD, Isales GM, Yozzo KL, Volz DC (2014) High-content screening assay for identification of chemicals impacting spontaneous activity in zebrafish embryos. Environ Sci Technol 48:804\u2013810. https:\/\/doi.org\/10.1021\/es404322p","journal-title":"Environ Sci Technol"},{"key":"3618_CR15","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.bbr.2011.11.041","volume":"228","author":"H Richendrfer","year":"2012","unstructured":"Richendrfer H, Pelkowski SD, Colwill RM, Creton R (2012) On the edge: Pharmacological evidence for anxiety-related behavior in zebrafish larvae. Behav Brain Res 228:99\u2013106. https:\/\/doi.org\/10.1016\/j.bbr.2011.11.041","journal-title":"Behav Brain Res"},{"key":"3618_CR16","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/biomedicines7010023","volume":"7","author":"RM Basnet","year":"2019","unstructured":"Basnet RM, Zizioli D, Taweedet S et al (2019) Zebrafish larvae as a behavioral model in neuropharmacology. Biomedicines 7:23. https:\/\/doi.org\/10.3390\/biomedicines7010023","journal-title":"Biomedicines"},{"key":"3618_CR17","doi-asserted-by":"publisher","first-page":"5786","DOI":"10.3390\/molecules26195786","volume":"26","author":"C Arteaga","year":"2021","unstructured":"Arteaga C, Boix N, Teixido E et al (2021) The zebrafish embryo as a model to test protective effects of food antioxidant compounds. Molecules 26:5786. https:\/\/doi.org\/10.3390\/molecules26195786","journal-title":"Molecules"},{"key":"3618_CR18","doi-asserted-by":"publisher","first-page":"E1109","DOI":"10.3390\/ijms21031109","volume":"21","author":"Y Endo","year":"2020","unstructured":"Endo Y, Muraki K, Fuse Y, Kobayashi M (2020) Evaluation of antioxidant activity of spice-derived phytochemicals using zebrafish. Int J Mol Sci 21:E1109. https:\/\/doi.org\/10.3390\/ijms21031109","journal-title":"Int J Mol Sci"},{"key":"3618_CR19","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3390\/antiox10010112","volume":"10","author":"S Kim","year":"2021","unstructured":"Kim S, Kim M, Kang M-C et al (2021) Antioxidant effects of turmeric leaf extract against hydrogen peroxide-induced oxidative stress in vitro in vero cells and in vivo in zebrafish. Antioxid Basel Switz 10:112. https:\/\/doi.org\/10.3390\/antiox10010112","journal-title":"Antioxid Basel Switz"},{"key":"3618_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.648107","volume":"12","author":"R Zhang","year":"2021","unstructured":"Zhang R, Zhao T, Zheng B et al (2021) Curcumin derivative Cur20 attenuated cerebral ischemic injury by antioxidant effect and HIF-1\u03b1\/VEGF\/TFEB-activated angiogenesis. Front Pharmacol 12:648107. https:\/\/doi.org\/10.3389\/fphar.2021.648107","journal-title":"Front Pharmacol"},{"key":"3618_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.112035","volume":"142","author":"BKM Choo","year":"2021","unstructured":"Choo BKM, Kundap UP, Faudzi SMM et al (2021) Identification of curcumin analogues with anti-seizure potential in vivo using chemical and genetic zebrafish larva seizure models. Biomed Pharmacother Biomed Pharmacother 142:112035. https:\/\/doi.org\/10.1016\/j.biopha.2021.112035","journal-title":"Biomed Pharmacother Biomed Pharmacother"},{"key":"3618_CR22","doi-asserted-by":"publisher","first-page":"109","DOI":"10.2741\/E850","volume":"11","author":"A Muthuraman","year":"2019","unstructured":"Muthuraman A, Thilagavathi L, Jabeen S et al (2019) Curcumin prevents cigarette smoke extract induced cognitive impairment. Front Biosci Elite Ed 11:109\u2013120. https:\/\/doi.org\/10.2741\/E850","journal-title":"Front Biosci Elite Ed"},{"key":"3618_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102781","volume":"66","author":"K Coradini","year":"2021","unstructured":"Coradini K, de Andrade DF, Altenhofen S et al (2021) Free and nanoencapsulated curcumin prevents scopolamine-induced cognitive impairment in adult zebrafish. J Drug Deliv Sci Technol 66:102781. https:\/\/doi.org\/10.1016\/j.jddst.2021.102781","journal-title":"J Drug Deliv Sci Technol"},{"key":"3618_CR24","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1021\/mp700113r","volume":"4","author":"P Anand","year":"2007","unstructured":"Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB (2007) Bioavailability of curcumin: problems and promises. Mol Pharm 4:807\u2013818. https:\/\/doi.org\/10.1021\/mp700113r","journal-title":"Mol Pharm"},{"key":"3618_CR25","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jchromb.2007.03.010","volume":"853","author":"K-Y Yang","year":"2007","unstructured":"Yang K-Y, Lin L-C, Tseng T-Y et al (2007) Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC\u2013MS\/MS. J Chromatogr B 853:183\u2013189. https:\/\/doi.org\/10.1016\/j.jchromb.2007.03.010","journal-title":"J Chromatogr B"},{"key":"3618_CR26","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.supflu.2017.06.010","volume":"130","author":"GPS Aguiar","year":"2017","unstructured":"Aguiar GPS, Marcon M, Mocelin R et al (2017) Micronization of N-acetylcysteine by supercritical fluid: evaluation of in vitro and in vivo biological activity. J Supercrit Fluids 130:282\u2013291. https:\/\/doi.org\/10.1016\/j.supflu.2017.06.010","journal-title":"J Supercrit Fluids"},{"key":"3618_CR27","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s11064-020-03158-0","volume":"46","author":"ER Almeida","year":"2021","unstructured":"Almeida ER, Lima-Rezende CA, Schneider SE et al (2021) Micronized resveratrol shows anticonvulsant properties in pentylenetetrazole-induced seizure model in adult zebrafish. Neurochem Res 46:241\u2013251. https:\/\/doi.org\/10.1007\/s11064-020-03158-0","journal-title":"Neurochem Res"},{"key":"3618_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2019.106243","volume":"159","author":"L Decui","year":"2020","unstructured":"Decui L, Garbinato CLL, Schneider SE et al (2020) Micronized resveratrol shows promising effects in a seizure model in zebrafish and signalizes an important advance in epilepsy treatment. Epilepsy Res 159:106243. https:\/\/doi.org\/10.1016\/j.eplepsyres.2019.106243","journal-title":"Epilepsy Res"},{"key":"3618_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2021.114501","volume":"177","author":"A Sachett","year":"2022","unstructured":"Sachett A, Gallas-Lopes M, Benvenutti R et al (2022) Curcumin micronization by supercritical fluid: in vitro and in vivo biological relevance. Ind Crops Prod 177:114501. https:\/\/doi.org\/10.1016\/j.indcrop.2021.114501","journal-title":"Ind Crops Prod"},{"key":"3618_CR30","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8831583","volume":"2021","author":"X Liang","year":"2021","unstructured":"Liang X, Xu G, Li Z et al (2021) Effect of micronization on panax notoginseng: in vitro dissolution and in vivo bioavailability evaluations. Evid Based Complement Alternat Med 2021:e8831583. https:\/\/doi.org\/10.1155\/2021\/8831583","journal-title":"Evid Based Complement Alternat Med"},{"key":"3618_CR31","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/s0049-3848(98)00216-3","volume":"94","author":"L McGregor","year":"1999","unstructured":"McGregor L, Bellangeon M, Chignier E et al (1999) Effect of a micronized purified flavonoid fraction on in vivo platelet functions in the rat. Thromb Res 94:235\u2013240. https:\/\/doi.org\/10.1016\/s0049-3848(98)00216-3","journal-title":"Thromb Res"},{"key":"3618_CR32","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/s0021-9150(02)00321-0","volume":"166","author":"E Cavallero","year":"2003","unstructured":"Cavallero E, Dachet C, Assadolahi F et al (2003) Micronized fenofibrate normalizes the enhanced lipidemic response to a fat load in patients with type 2 diabetes and optimal glucose control. Atherosclerosis 166:151\u2013161. https:\/\/doi.org\/10.1016\/s0021-9150(02)00321-0","journal-title":"Atherosclerosis"},{"key":"3618_CR33","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1097\/00005344-200301000-00008","volume":"41","author":"J Ducobu","year":"2003","unstructured":"Ducobu J, VanHaelst L, Salomon H (2003) Comparison of micronized fenofibrate and pravastatin in patients with primary hyperlipidemia. J Cardiovasc Pharmacol 41:60\u201367. https:\/\/doi.org\/10.1097\/00005344-200301000-00008","journal-title":"J Cardiovasc Pharmacol"},{"key":"3618_CR34","doi-asserted-by":"publisher","first-page":"155","DOI":"10.2165\/00003088-199834020-00003","volume":"34","author":"DB Miller","year":"1998","unstructured":"Miller DB, Spence JD (1998) Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clin Pharmacokinet 34:155\u2013162. https:\/\/doi.org\/10.2165\/00003088-199834020-00003","journal-title":"Clin Pharmacokinet"},{"key":"3618_CR35","doi-asserted-by":"publisher","first-page":"67","DOI":"10.4103\/2230-8210.172243","volume":"20","author":"P Patel","year":"2016","unstructured":"Patel P, Barkate H (2016) Comparison of efficacy and safety of choline fenofibrate (fenofibric acid) to micronized fenofibrate in patients of mixed dyslipidemia: a randomized, open-label, multicenter clinical trial in Indian population. Indian J Endocrinol Metab 20:67\u201371. https:\/\/doi.org\/10.4103\/2230-8210.172243","journal-title":"Indian J Endocrinol Metab"},{"key":"3618_CR36","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1111\/bcp.13020","volume":"82","author":"L Gabrielsson","year":"2016","unstructured":"Gabrielsson L, Mattsson S, Fowler CJ (2016) Palmitoylethanolamide for the treatment of pain: pharmacokinetics, safety and efficacy. Br J Clin Pharmacol 82:932\u2013942. https:\/\/doi.org\/10.1111\/bcp.13020","journal-title":"Br J Clin Pharmacol"},{"key":"3618_CR37","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1111\/bph.13580","volume":"174","author":"S Petrosino","year":"2017","unstructured":"Petrosino S, Di Marzo V (2017) The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations. Br J Pharmacol 174:1349\u20131365. https:\/\/doi.org\/10.1111\/bph.13580","journal-title":"Br J Pharmacol"},{"key":"3618_CR38","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/s0015-0282(99)00272-1","volume":"72","author":"LA Fitzpatrick","year":"1999","unstructured":"Fitzpatrick LA, Good A (1999) Micronized progesterone: clinical indications and comparison with current treatments. Fertil Steril 72:389\u2013397. https:\/\/doi.org\/10.1016\/s0015-0282(99)00272-1","journal-title":"Fertil Steril"},{"key":"3618_CR39","doi-asserted-by":"publisher","DOI":"10.7573\/dic.2021-7-1","author":"GN Wagh","year":"2021","unstructured":"Wagh GN, Kundavi Shankar KM, Bachani S (2021) A review of conventional and sustained-release formulations of oral natural micronized progesterone in obstetric indications. Drugs Context. https:\/\/doi.org\/10.7573\/dic.2021-7-1","journal-title":"Drugs Context"},{"key":"3618_CR40","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1007\/s40122-021-00312-6","volume":"10","author":"RV Akhmetzianov","year":"2021","unstructured":"Akhmetzianov RV, Bredikhin RA (2021) Clinical efficacy of conservative treatment with micronized purified flavonoid fraction in female patients with pelvic congestion syndrome. Pain Ther 10:1567\u20131578. https:\/\/doi.org\/10.1007\/s40122-021-00312-6","journal-title":"Pain Ther"},{"key":"3618_CR41","first-page":"61","volume":"8","author":"M Cospite","year":"1989","unstructured":"Cospite M, Dominici A (1989) Double blind study of the pharmacodynamic and clinical activities of 5682 SE in venous insufficiency. Advantages of the new micronized form. Int Angiol J Int Union Angiol 8:61\u201365","journal-title":"Int Angiol J Int Union Angiol"},{"key":"3618_CR42","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1007\/s12325-018-0794-x","volume":"35","author":"EA Zagriadski\u012d","year":"2018","unstructured":"Zagriadski\u012d EA, Bogomazov AM, Golovko EB (2018) Conservative treatment of hemorrhoids: results of an observational multicenter study. Adv Ther 35:1979\u20131992. https:\/\/doi.org\/10.1007\/s12325-018-0794-x","journal-title":"Adv Ther"},{"key":"3618_CR43","doi-asserted-by":"publisher","first-page":"9458","DOI":"10.1021\/jf502933v","volume":"62","author":"M Tom\u00e1s-Navarro","year":"2014","unstructured":"Tom\u00e1s-Navarro M, Vallejo F, Borrego F, Tom\u00e1s-Barber\u00e1n FA (2014) Encapsulation and micronization effectively improve orange beverage flavanone bioavailability in humans. J Agric Food Chem 62:9458\u20139462. https:\/\/doi.org\/10.1021\/jf502933v","journal-title":"J Agric Food Chem"},{"key":"3618_CR44","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1158\/1940-6207.CAPR-11-0148","volume":"4","author":"LM Howells","year":"2011","unstructured":"Howells LM, Berry DP, Elliott PJ et al (2011) Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases\u2014safety, pharmacokinetics, and pharmacodynamics. Cancer Prev Res Phila Pa 4:1419\u20131425. https:\/\/doi.org\/10.1158\/1940-6207.CAPR-11-0148","journal-title":"Cancer Prev Res Phila Pa"},{"key":"3618_CR45","doi-asserted-by":"publisher","DOI":"10.1101\/2021.10.11.463974","author":"A Sachett","year":"2021","unstructured":"Sachett A, Gallas-Lopes M, Benvenutti R et al (2021) Non-micronized and micronized curcumin do not prevent the behavioral and neurochemical effects induced by acute stress in zebrafish. bioRxiv. https:\/\/doi.org\/10.1101\/2021.10.11.463974","journal-title":"bioRxiv"},{"key":"3618_CR46","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.bbr.2011.03.025","volume":"222","author":"PJ Steenbergen","year":"2011","unstructured":"Steenbergen PJ, Richardson MK, Champagne DL (2011) Patterns of avoidance behaviours in the light\/dark preference test in young juvenile zebrafish: a pharmacological study. Behav Brain Res 222:15\u201325. https:\/\/doi.org\/10.1016\/j.bbr.2011.03.025","journal-title":"Behav Brain Res"},{"key":"3618_CR47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077548","volume":"8","author":"A Fleming","year":"2013","unstructured":"Fleming A, Diekmann H, Goldsmith P (2013) Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS ONE 8:e77548. https:\/\/doi.org\/10.1371\/journal.pone.0077548","journal-title":"PLoS ONE"},{"key":"3618_CR48","doi-asserted-by":"publisher","first-page":"3617","DOI":"10.1111\/bph.15193","volume":"177","author":"NP du Sert","year":"2020","unstructured":"du Sert NP, Hurst V, Ahluwalia A et al (2020) The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. Br J Pharmacol 177:3617\u20133624. https:\/\/doi.org\/10.1111\/bph.15193","journal-title":"Br J Pharmacol"},{"key":"3618_CR49","volume-title":"AVMA guidelines for the euthanasia of animals","author":"S Leary","year":"2020","unstructured":"Leary S, Pharmaceuticals F, Underwood W et al (2020) AVMA guidelines for the euthanasia of animals, 2020th edn. American Veterinary Medical Association, Schaumburg","edition":"2020"},{"key":"3618_CR50","doi-asserted-by":"crossref","unstructured":"Creton R (2009) Automated analysis of behavior in zebrafish larvae. In: Behav Brain Res. https:\/\/pubmed.ncbi.nlm.nih.gov\/19409932\/. Accessed 1 Dec 2020","DOI":"10.1016\/j.bbr.2009.04.030"},{"key":"3618_CR51","doi-asserted-by":"publisher","first-page":"2959","DOI":"10.1007\/s11064-017-2327-4","volume":"42","author":"LR Nery","year":"2017","unstructured":"Nery LR, Silva NE, Fonseca R, Vianna MRM (2017) Presenilin-1 targeted morpholino induces cognitive deficits, increased brain A\u03b21-42 and decreased synaptic marker PSD-95 in zebrafish larvae. Neurochem Res 42:2959\u20132967. https:\/\/doi.org\/10.1007\/s11064-017-2327-4","journal-title":"Neurochem Res"},{"key":"3618_CR52","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.bbr.2011.04.033","volume":"223","author":"SD Pelkowski","year":"2011","unstructured":"Pelkowski SD, Kapoor M, Richendrfer HA et al (2011) A novel high-throughput imaging system for automated analyses of avoidance behavior in zebrafish larvae. Behav Brain Res 223:135\u2013144. https:\/\/doi.org\/10.1016\/j.bbr.2011.04.033","journal-title":"Behav Brain Res"},{"key":"3618_CR53","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1006\/abio.1976.9999","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254. https:\/\/doi.org\/10.1006\/abio.1976.9999","journal-title":"Anal Biochem"},{"key":"3618_CR54","doi-asserted-by":"publisher","DOI":"10.17504\/protocols.io.bjnfkmbn","author":"A Sachett","year":"2020","unstructured":"Sachett A (2020) Protein quantification protocol optimized for zebrafish brain tissue (Bradford method). Protocols.io. https:\/\/doi.org\/10.17504\/protocols.io.bjnfkmbn","journal-title":"Protocols.io"},{"key":"3618_CR55","doi-asserted-by":"crossref","unstructured":"Sachett A, Gallas-Lopes M, Conterato GMM, et al (2021) Quantification of nonprotein sulfhydryl groups (NPSH) optimized for zebrafish brain tissue. In: protocols.io. https:\/\/www.protocols.io\/view\/quantification-of-nonprotein-sulfhydryl-groups-nps-bx8tprwn. Accessed 11 Oct 2021","DOI":"10.17504\/protocols.io.bx8tprwn"},{"key":"3618_CR56","doi-asserted-by":"publisher","DOI":"10.17504\/protocols.io.bjp8kmrw","author":"A Sachett","year":"2020","unstructured":"Sachett A (2020) Quantification of thiobarbituric acid reactive species (TBARS) optimized for zebrafish brain tissue. Protocols.io. https:\/\/doi.org\/10.17504\/protocols.io.bjp8kmrw","journal-title":"Protocols.io"},{"key":"3618_CR57","doi-asserted-by":"crossref","unstructured":"Brustein E, Brustein S-A, Buss R, et al (2003) Steps during the development of the zebrafish locomotor network. In: J Physiol Paris. https:\/\/pubmed.ncbi.nlm.nih.gov\/14706693\/. Accessed 1 Dec 2020","DOI":"10.1016\/j.jphysparis.2003.10.009"},{"key":"3618_CR58","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/s0301-0082(02)00075-8","volume":"68","author":"P Drapeau","year":"2002","unstructured":"Drapeau P, Saint-Amant L, Buss RR et al (2002) Development of the locomotor network in zebrafish. Prog Neurobiol 68:85\u2013111. https:\/\/doi.org\/10.1016\/s0301-0082(02)00075-8","journal-title":"Prog Neurobiol"},{"key":"3618_CR59","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1089\/zeb.2012.0860","volume":"10","author":"AR Blazina","year":"2013","unstructured":"Blazina AR, Vianna MR, Lara DR (2013) The spinning task: a new protocol to easily assess motor coordination and resistance in zebrafish. Zebrafish 10:480\u2013485. https:\/\/doi.org\/10.1089\/zeb.2012.0860","journal-title":"Zebrafish"},{"key":"3618_CR60","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1089\/zeb.2016.1372","volume":"14","author":"S Tran","year":"2017","unstructured":"Tran S, Chow H, Tsang B et al (2017) Zebrafish are able to detect ethanol in their environment. Zebrafish 14:126\u2013132. https:\/\/doi.org\/10.1089\/zeb.2016.1372","journal-title":"Zebrafish"},{"key":"3618_CR61","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ntt.2015.11.008","volume":"53","author":"X Liu","year":"2016","unstructured":"Liu X, Lin J, Zhang Y et al (2016) Effects of diphenylhydantoin on locomotion and thigmotaxis of larval zebrafish. Neurotoxicol Teratol 53:41\u201347. https:\/\/doi.org\/10.1016\/j.ntt.2015.11.008","journal-title":"Neurotoxicol Teratol"},{"key":"3618_CR62","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2021.107034","volume":"88","author":"DD Nabinger","year":"2021","unstructured":"Nabinger DD, Altenhofen S, Peixoto JV et al (2021) Long-lasting behavioral effects of quinpirole exposure on zebrafish. Neurotoxicol Teratol 88:107034. https:\/\/doi.org\/10.1016\/j.ntt.2021.107034","journal-title":"Neurotoxicol Teratol"},{"key":"3618_CR63","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1007\/s00213-016-4264-3","volume":"233","author":"S Tran","year":"2016","unstructured":"Tran S, Facciol A, Gerlai R (2016) Alcohol-induced behavioral changes in zebrafish: the role of dopamine D2-like receptors. Psychopharmacology 233:2119\u20132128. https:\/\/doi.org\/10.1007\/s00213-016-4264-3","journal-title":"Psychopharmacology"},{"key":"3618_CR64","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s00213-008-1300-y","volume":"201","author":"SK Kulkarni","year":"2008","unstructured":"Kulkarni SK, Bhutani MK, Bishnoi M (2008) Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology 201:435. https:\/\/doi.org\/10.1007\/s00213-008-1300-y","journal-title":"Psychopharmacology"},{"key":"3618_CR65","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.ejphar.2005.06.002","volume":"518","author":"Y Xu","year":"2005","unstructured":"Xu Y, Ku B-S, Yao H-Y et al (2005) The effects of curcumin on depressive-like behaviors in mice. Eur J Pharmacol 518:40\u201346. https:\/\/doi.org\/10.1016\/j.ejphar.2005.06.002","journal-title":"Eur J Pharmacol"},{"key":"3618_CR66","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ntt.2017.10.009","volume":"69","author":"H Richendrfer","year":"2018","unstructured":"Richendrfer H, Creton R (2018) Cluster analysis profiling of behaviors in zebrafish larvae treated with antidepressants and pesticides. Neurotoxicol Teratol 69:54\u201362. https:\/\/doi.org\/10.1016\/j.ntt.2017.10.009","journal-title":"Neurotoxicol Teratol"},{"key":"3618_CR67","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1097\/HNP.0000000000000208","volume":"31","author":"TE Ceremuga","year":"2017","unstructured":"Ceremuga TE, Helmrick K, Kufahl Z et al (2017) Investigation of the anxiolytic and antidepressant effects of curcumin, a compound from turmeric (Curcuma longa), in the adult male Sprague-Dawley rat. Holist Nurs Pract 31:193\u2013203. https:\/\/doi.org\/10.1097\/HNP.0000000000000208","journal-title":"Holist Nurs Pract"},{"key":"3618_CR68","doi-asserted-by":"publisher","first-page":"5587","DOI":"10.1007\/s11033-020-05590-5","volume":"47","author":"G Morris","year":"2020","unstructured":"Morris G, Walder KR, Berk M et al (2020) The interplay between oxidative stress and bioenergetic failure in neuropsychiatric illnesses: can we explain it and can we treat it? Mol Biol Rep 47:5587\u20135620. https:\/\/doi.org\/10.1007\/s11033-020-05590-5","journal-title":"Mol Biol Rep"},{"key":"3618_CR69","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1042\/BJ20101695","volume":"434","author":"SV Avery","year":"2011","unstructured":"Avery SV (2011) Molecular targets of oxidative stress. Biochem J 434:201\u2013210. https:\/\/doi.org\/10.1042\/BJ20101695","journal-title":"Biochem J"},{"key":"3618_CR70","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.yfrne.2018.01.001","volume":"49","author":"M Picard","year":"2018","unstructured":"Picard M, McEwen BS, Epel ES, Sandi C (2018) An energetic view of stress: focus on mitochondria. Front Neuroendocrinol 49:72\u201385. https:\/\/doi.org\/10.1016\/j.yfrne.2018.01.001","journal-title":"Front Neuroendocrinol"},{"key":"3618_CR71","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/0166-2236(85)90010-4","volume":"8","author":"B Halliwell","year":"1985","unstructured":"Halliwell B, Gutteridge JMC (1985) Oxygen radicals and the nervous system. Trends Neurosci 8:22\u201326. https:\/\/doi.org\/10.1016\/0166-2236(85)90010-4","journal-title":"Trends Neurosci"},{"issue":"1\u201330","key":"3618_CR72","doi-asserted-by":"publisher","first-page":"v","DOI":"10.1016\/j.cvsm.2007.10.005","volume":"38","author":"L Mandelker","year":"2008","unstructured":"Mandelker L (2008) Introduction to oxidative stress and mitochondrial dysfunction. Vet Clin North Am Small Anim Pract 38(1\u201330):v. https:\/\/doi.org\/10.1016\/j.cvsm.2007.10.005","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"3618_CR73","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1080\/10715760802317663","volume":"42","author":"ML Circu","year":"2008","unstructured":"Circu ML, Aw TY (2008) Glutathione and apoptosis. Free Radic Res 42:689\u2013706. https:\/\/doi.org\/10.1080\/10715760802317663","journal-title":"Free Radic Res"},{"key":"3618_CR74","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","volume":"524","author":"D Tsikas","year":"2017","unstructured":"Tsikas D (2017) Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges. Anal Biochem 524:13\u201330. https:\/\/doi.org\/10.1016\/j.ab.2016.10.021","journal-title":"Anal Biochem"},{"key":"3618_CR75","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cbi.2008.05.003","volume":"174","author":"T Ak","year":"2008","unstructured":"Ak T, G\u00fcl\u00e7in I (2008) Antioxidant and radical scavenging properties of curcumin. Chem Biol Interact 174:27\u201337. https:\/\/doi.org\/10.1016\/j.cbi.2008.05.003","journal-title":"Chem Biol Interact"},{"key":"3618_CR76","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/978-0-387-46401-5_3","volume-title":"The molecular targets and therapeutic uses of curcumin in health and disease","author":"VP Menon","year":"2007","unstructured":"Menon VP, Sudheer AR (2007) Antioxidant and anti-inflammatory properties of curcuMIN. In: Aggarwal BB, Surh Y-J, Shishodia S (eds) The molecular targets and therapeutic uses of curcumin in health and disease. Springer, Boston, pp 105\u2013125"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-022-03618-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-022-03618-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-022-03618-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T02:13:10Z","timestamp":1659579190000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-022-03618-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,10]]},"references-count":76,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["3618"],"URL":"https:\/\/doi.org\/10.1007\/s11064-022-03618-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.11.29.470475","asserted-by":"object"}]},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,10]]},"assertion":[{"value":"16 December 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 April 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 May 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}