{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:15:57Z","timestamp":1781846157088,"version":"3.54.5"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["2016-0264\/CMB\/Adhoc-BMS"],"award-info":[{"award-number":["2016-0264\/CMB\/Adhoc-BMS"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1007\/s11064-022-03691-0","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T16:03:09Z","timestamp":1659542589000},"page":"3385-3401","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["4-Phenylbutyrate Mitigates the Motor Impairment and Dopaminergic Neuronal Death During Parkinson\u2019s Disease Pathology via Targeting VDAC1 Mediated Mitochondrial Function and Astrocytes Activation"],"prefix":"10.1007","volume":"47","author":[{"given":"Shubhangini","family":"Tiwari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parul","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Chaturvedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wahajuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6195-9029","authenticated-orcid":false,"given":"Sarika","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"3691_CR1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/978-1-0716-1712-0_7","volume":"173","author":"A Surguchov","year":"2022","unstructured":"Surguchov A (2022) Biomarkers in Parkinson\u2019s disease. NeuroMethods 173:155\u2013180. https:\/\/doi.org\/10.1007\/978-1-0716-1712-0_7","journal-title":"NeuroMethods"},{"key":"3691_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2010.00012","author":"X Wang","year":"2010","unstructured":"Wang X, Michaelis EK (2010) Selective neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci. https:\/\/doi.org\/10.3389\/fnagi.2010.00012","journal-title":"Front Aging Neurosci"},{"key":"3691_CR3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.brainresrev.2007.02.001","volume":"54","author":"S Singh","year":"2007","unstructured":"Singh S, Dikshit M (2007) Apoptotic neuronal death in Parkinson\u2019s disease: involvement of nitric oxide. Brain Res Rev 54:233\u2013250","journal-title":"Brain Res Rev"},{"key":"3691_CR4","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1179\/174329210X12650506623447","volume":"15","author":"S Singh","year":"2010","unstructured":"Singh S, Kumar S, Dikshit M (2010) Involvement of the mitochondrial apoptotic pathway and nitric oxide synthase in dopaminergic neuronal death induced by 6-hydroxydopamine and lipopolysaccharide. Redox Rep 15:115\u2013122. https:\/\/doi.org\/10.1179\/174329210X12650506623447","journal-title":"Redox Rep"},{"issue":"4","key":"3691_CR5","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1177\/1073858420942211","volume":"27","author":"S Tiwari","year":"2020","unstructured":"Tiwari S, Singh S (2020) Reciprocal upshot of nitric oxide, endoplasmic reticulum stress, and ubiquitin proteasome system in Parkinson\u2019s disease pathology. Neuroscientist 27(4):340","journal-title":"Neuroscientist"},{"key":"3691_CR6","doi-asserted-by":"publisher","first-page":"224","DOI":"10.3389\/FNMOL.2017.00224\/BIBTEX","volume":"10","author":"AA Surguchev","year":"2017","unstructured":"Surguchev AA, Surguchov A (2017) Synucleins and gene expression: ramblers in a crowd or cops regulating traffic? Front Mol Neurosci 10:224. https:\/\/doi.org\/10.3389\/FNMOL.2017.00224\/BIBTEX","journal-title":"Front Mol Neurosci"},{"key":"3691_CR7","doi-asserted-by":"publisher","first-page":"5384","DOI":"10.1007\/s12035-015-9463-0","volume":"53","author":"P Goswami","year":"2016","unstructured":"Goswami P, Gupta S, Biswas J et al (2016) Endoplasmic reticulum stress instigates the rotenone induced oxidative apoptotic neuronal death: a study in rat brain. Mol Neurobiol 53:5384\u20135400. https:\/\/doi.org\/10.1007\/s12035-015-9463-0","journal-title":"Mol Neurobiol"},{"key":"3691_CR8","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1111\/j.1582-4934.2011.01374.x","volume":"15","author":"KM Doyle","year":"2011","unstructured":"Doyle KM, Kennedy D, Gorman AM et al (2011) Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. J Cell Mol Med 15:2025\u20132039","journal-title":"J Cell Mol Med"},{"key":"3691_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS9112495","author":"CA da Costa","year":"2020","unstructured":"da Costa CA, el Manaa W, Duplan E, Checler F (2020) The endoplasmic reticulum stress\/unfolded protein response and their contributions to Parkinson\u2019s disease physiopathology. Cells. https:\/\/doi.org\/10.3390\/CELLS9112495","journal-title":"Cells"},{"key":"3691_CR10","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1056\/nejm199609193351204","volume":"335","author":"NE Maestri","year":"1996","unstructured":"Maestri NE, Brusilow SW, Clissold DB, Bassett SS (1996) Long-term treatment of girls with ornithine transcarbamylase deficiency. N Engl J Med 335:855\u2013860. https:\/\/doi.org\/10.1056\/nejm199609193351204","journal-title":"N Engl J Med"},{"key":"3691_CR11","doi-asserted-by":"publisher","DOI":"10.1093\/femsyr\/foy016","author":"CT Mai","year":"2018","unstructured":"Mai CT, Le QG, Ishiwata-Kimata Y et al (2018) 4-Phenylbutyrate suppresses the unfolded protein response without restoring protein folding in Saccharomyces cerevisiae. FEMS Yeast Res. https:\/\/doi.org\/10.1093\/femsyr\/foy016","journal-title":"FEMS Yeast Res"},{"key":"3691_CR12","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6404035","author":"Y Rellmann","year":"2019","unstructured":"Rellmann Y, Gronau I, Hansen U et al (2019) 4-Phenylbutyric acid reduces endoplasmic reticulum stress in chondrocytes that is caused by loss of the protein disulfide isomerase ERp57. Oxid Med Cell Longev. https:\/\/doi.org\/10.1155\/2019\/6404035","journal-title":"Oxid Med Cell Longev"},{"key":"3691_CR13","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1111\/j.1471-4159.2006.04440.x","volume":"101","author":"M Inden","year":"2007","unstructured":"Inden M, Kitamura Y, Takeuchi H et al (2007) Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone. J Neurochem 101:1491\u20131504. https:\/\/doi.org\/10.1111\/j.1471-4159.2006.04440.x","journal-title":"J Neurochem"},{"key":"3691_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2021.109922","author":"S Gupta","year":"2021","unstructured":"Gupta S, Mishra A, Singh S (2021) Cardinal role of eukaryotic initiation factor 2 (eIF2\u03b1) in progressive dopaminergic neuronal death & DNA fragmentation: implication of PERK:IRE1\u03b1:ATF6 axis in Parkinson\u2019s pathology. Cell Signal. https:\/\/doi.org\/10.1016\/j.cellsig.2021.109922","journal-title":"Cell Signal"},{"key":"3691_CR15","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/J.MITO.2012.05.002","volume":"12","author":"D Santos","year":"2012","unstructured":"Santos D, Cardoso SM (2012) Mitochondrial dynamics and neuronal fate in Parkinson\u2019s disease. Mitochondrion 12:428\u2013437. https:\/\/doi.org\/10.1016\/J.MITO.2012.05.002","journal-title":"Mitochondrion"},{"key":"3691_CR16","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1111\/J.1471-4159.1990.TB02325.X","volume":"54","author":"AHV Schapira","year":"1990","unstructured":"Schapira AHV, Cooper JM, Dexter D et al (1990) Mitochondrial complex I deficiency in Parkinson\u2019s disease. J Neurochem 54:823\u2013827. https:\/\/doi.org\/10.1111\/J.1471-4159.1990.TB02325.X","journal-title":"J Neurochem"},{"key":"3691_CR17","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/NYAS.14212","volume":"1457","author":"P Veeresh","year":"2019","unstructured":"Veeresh P, Kaur H, Sarmah D et al (2019) Endoplasmic reticulum-mitochondria crosstalk: from junction to function across neurological disorders. Ann N Y Acad Sci 1457:41\u201360. https:\/\/doi.org\/10.1111\/NYAS.14212","journal-title":"Ann N Y Acad Sci"},{"key":"3691_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS222111444","author":"LE Millichap","year":"2021","unstructured":"Millichap LE, Damiani E, Tiano L, Hargreaves IP (2021) Targetable pathways for alleviating mitochondrial dysfunction in neurodegeneration of metabolic and non-metabolic diseases. Int J Mol Sci. https:\/\/doi.org\/10.3390\/IJMS222111444","journal-title":"Int J Mol Sci"},{"key":"3691_CR19","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1016\/S0140-6736(83)90802-4","volume":"2","author":"DB Calne","year":"1983","unstructured":"Calne DB, William Langston J (1983) Aetiology of Parkinson\u2019s disease. Lancet 2:1457\u20131459. https:\/\/doi.org\/10.1016\/S0140-6736(83)90802-4","journal-title":"Lancet"},{"key":"3691_CR20","doi-asserted-by":"publisher","first-page":"613","DOI":"10.3109\/10408444.2012.680431","volume":"42","author":"N Xiong","year":"2012","unstructured":"Xiong N, Long X, Xiong J et al (2012) Mitochondrial complex I inhibitor rotenone-induced toxicity and its potential mechanisms in Parkinson\u2019s disease models. Crit Rev Toxicol 42:613\u2013632. https:\/\/doi.org\/10.3109\/10408444.2012.680431","journal-title":"Crit Rev Toxicol"},{"key":"3691_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/JOURNAL.PONE.0007878","volume":"4","author":"N Xiong","year":"2009","unstructured":"Xiong N, Huang J, Zhang Z et al (2009) Stereotaxical infusion of rotenone: a reliable rodent model for Parkinson\u2019s disease. PLoS ONE 4:e7878. https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0007878","journal-title":"PLoS ONE"},{"key":"3691_CR22","unstructured":"The rat brain in stereotaxic coordinates\u20146th edition. https:\/\/www.elsevier.com\/books\/the-rat-brain-in-stereotaxic-coordinates\/paxinos\/978-0-12-374121-9. Accessed 4 May 2021"},{"key":"3691_CR23","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1124\/MOL.104.001339","volume":"66","author":"X Qi","year":"2004","unstructured":"Qi X, Hosoi T, Okuma Y et al (2004) Sodium 4-phenylbutyrate protects against cerebral ischemic injury. Mol Pharmacol 66:899\u2013908. https:\/\/doi.org\/10.1124\/MOL.104.001339","journal-title":"Mol Pharmacol"},{"key":"3691_CR24","doi-asserted-by":"publisher","DOI":"10.1093\/CVR\/CVAB280","author":"H Luo","year":"2021","unstructured":"Luo H, Lan C, Fan C et al (2021) Down-regulation of AMPK\/PPAR\u03b4 signalling promotes endoplasmic reticulum stress-induced endothelial dysfunction in adult rat offspring exposed to maternal diabetes. Cardiovasc Res. https:\/\/doi.org\/10.1093\/CVR\/CVAB280","journal-title":"Cardiovasc Res"},{"key":"3691_CR25","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1016\/J.METABOL.2010.07.021","volume":"60","author":"W Qi","year":"2011","unstructured":"Qi W, Mu J, Luo ZF et al (2011) Attenuation of diabetic nephropathy in diabetes rats induced by streptozotocin by regulating the endoplasmic reticulum stress inflammatory response. Metabolism 60:594\u2013603. https:\/\/doi.org\/10.1016\/J.METABOL.2010.07.021","journal-title":"Metabolism"},{"key":"3691_CR26","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s12640-018-9932-0","volume":"35","author":"A Bhardwaj","year":"2019","unstructured":"Bhardwaj A, Bhardwaj R, Dhawan DK, Kaur T (2019) Exploring the effect of endoplasmic reticulum stress inhibition by 4-phenylbutyric acid on AMPA-induced hippocampal excitotoxicity in rat brain. Neurotox Res 35:83\u201391. https:\/\/doi.org\/10.1007\/s12640-018-9932-0","journal-title":"Neurotox Res"},{"key":"3691_CR27","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-08052-4","author":"Z He","year":"2017","unstructured":"He Z, Zou S, Yin J et al (2017) Inhibition of endoplasmic reticulum stress preserves the integrity of blood-spinal cord barrier in diabetic rats subjected to spinal cord injury. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-017-08052-4","journal-title":"Sci Rep"},{"key":"3691_CR28","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.jneumeth.2006.06.001","volume":"158","author":"C Monville","year":"2006","unstructured":"Monville C, Torres EM, Dunnett SB (2006) Comparison of incremental and accelerating protocols of the rotarod test for the assessment of motor deficits in the 6-OHDA model. J Neurosci Methods 158:219\u2013223. https:\/\/doi.org\/10.1016\/j.jneumeth.2006.06.001","journal-title":"J Neurosci Methods"},{"key":"3691_CR29","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/J.CELLSIG.2017.10.018","volume":"42","author":"J Biswas","year":"2018","unstructured":"Biswas J, Gupta S, Verma DK et al (2018) Involvement of glucose related energy crisis and endoplasmic reticulum stress: insinuation of streptozotocin induced Alzheimer\u2019s like pathology. Cell Signal 42:211\u2013226. https:\/\/doi.org\/10.1016\/J.CELLSIG.2017.10.018","journal-title":"Cell Signal"},{"key":"3691_CR30","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1007\/S00441-021-03570-0","volume":"388","author":"A Singh","year":"2022","unstructured":"Singh A, Gupta P, Tiwari S et al (2022) Guanabenz mitigates the neuropathological alterations and cell death in Alzheimer\u2019s disease. Cell Tissue Res 388:239\u2013258. https:\/\/doi.org\/10.1007\/S00441-021-03570-0","journal-title":"Cell Tissue Res"},{"key":"3691_CR31","doi-asserted-by":"publisher","unstructured":"Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent*. https:\/\/doi.org\/10.1016\/S0021-9258(19)52451-6","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"3691_CR32","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1038\/nprot.2006.478","volume":"2","author":"C Frezza","year":"2007","unstructured":"Frezza C, Cipolat S, Scorrano L (2007) Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts. Nat Protoc 2:287\u2013295. https:\/\/doi.org\/10.1038\/nprot.2006.478","journal-title":"Nat Protoc"},{"key":"3691_CR33","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112433","volume":"155","author":"A Singh","year":"2021","unstructured":"Singh A, Yadawa AK, Chaturvedi S et al (2021) Mechanism for antiParkinsonian effect of resveratrol: involvement of transporters, synaptic proteins, dendrite arborization, biochemical alterations, ER stress and apoptosis. Food Chem Toxicol 155:112433. https:\/\/doi.org\/10.1016\/j.fct.2021.112433","journal-title":"Food Chem Toxicol"},{"key":"3691_CR34","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1042\/BCJ20200754","volume":"478","author":"P Gupta","year":"2021","unstructured":"Gupta P, Tiwari S, Singh A et al (2021) Rivastigmine attenuates the Alzheimer\u2019s disease related protein degradation and apoptotic neuronal death signalling. Biochem J 478:1435\u20131451. https:\/\/doi.org\/10.1042\/BCJ20200754","journal-title":"Biochem J"},{"key":"3691_CR35","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1016\/j.bbadis.2018.03.014","volume":"1864","author":"DK Verma","year":"2018","unstructured":"Verma DK, Gupta S, Biswas J et al (2018) New therapeutic activity of metabolic enhancer piracetam in treatment of neurodegenerative disease: participation of caspase independent death factors, oxidative stress, inflammatory responses and apoptosis. Biochim Biophys Acta 1864:2078\u20132096. https:\/\/doi.org\/10.1016\/j.bbadis.2018.03.014","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"3691_CR36","doi-asserted-by":"publisher","first-page":"3159","DOI":"10.1038\/nprot.2006.378","volume":"1","author":"I Rahman","year":"2007","unstructured":"Rahman I, Kode A, Biswas SK (2007) Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method. Nat Protoc 1(6):3159\u20133165. https:\/\/doi.org\/10.1038\/nprot.2006.378","journal-title":"Nat Protoc"},{"key":"3691_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.104581","author":"S Gupta","year":"2019","unstructured":"Gupta S, Biswas J, Gupta P et al (2019) Salubrinal attenuates nitric oxide mediated PERK:IRE1\u03b1: ATF-6 signaling and DNA damage in neuronal cells. Neurochem Int. https:\/\/doi.org\/10.1016\/j.neuint.2019.104581","journal-title":"Neurochem Int"},{"key":"3691_CR38","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1006\/EXNR.2002.8056","volume":"179","author":"M Nakai","year":"2003","unstructured":"Nakai M, Mori A, Watanabe A, Mitsumoto Y (2003) 1-Methyl-4-phenylpyridinium (MPP+) decreases mitochondrial oxidation-reduction (REDOX) activity and membrane potential (Deltapsi(m)) in rat striatum. Exp Neurol 179:103\u2013110. https:\/\/doi.org\/10.1006\/EXNR.2002.8056","journal-title":"Exp Neurol"},{"key":"3691_CR39","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/J.NEUINT.2018.04.013","volume":"118","author":"M Zilocchi","year":"2018","unstructured":"Zilocchi M, Finzi G, Lualdi M et al (2018) Mitochondrial alterations in Parkinson\u2019s disease human samples and cellular models. Neurochem Int 118:61\u201372. https:\/\/doi.org\/10.1016\/J.NEUINT.2018.04.013","journal-title":"Neurochem Int"},{"key":"3691_CR40","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399409001094","volume":"11","author":"MR Vargas","year":"2009","unstructured":"Vargas MR, Johnson JA (2009) The Nrf2-ARE cytoprotective pathway in astrocytes. Expert Rev Mol Med 11:e17. https:\/\/doi.org\/10.1017\/S1462399409001094","journal-title":"Expert Rev Mol Med"},{"key":"3691_CR41","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3109\/00207454.2016.1173692","volume":"127","author":"S Singh","year":"2017","unstructured":"Singh S, Joshi N (2017) Astrocytes: inexplicable cells in neurodegeneration. Int J Neurosci 127:204\u2013209","journal-title":"Int J Neurosci"},{"key":"3691_CR42","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/jnr.24185","volume":"96","author":"N Joshi","year":"2018","unstructured":"Joshi N, Singh S (2018) Updates on immunity and inflammation in Parkinson disease pathology. J Neurosci Res 96:379\u2013390","journal-title":"J Neurosci Res"},{"key":"3691_CR43","doi-asserted-by":"publisher","first-page":"12300","DOI":"10.1073\/pnas.0404764101","volume":"101","author":"G Bonapace","year":"2004","unstructured":"Bonapace G, Waheed A, Shah GN, Sly WS (2004) Chemical chaperones protect from effects of apoptosis-inducing mutation in carbonic anhydrase IV identified in retinitis pigmentosa 17. Proc Natl Acad Sci USA 101:12300\u201312305. https:\/\/doi.org\/10.1073\/pnas.0404764101","journal-title":"Proc Natl Acad Sci USA"},{"key":"3691_CR44","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/J.VPH.2016.03.004","volume":"83","author":"K Jain","year":"2016","unstructured":"Jain K, Suryakumar G, Ganju L, Singh SB (2016) Amelioration of ER stress by 4-phenylbutyric acid reduces chronic hypoxia induced cardiac damage and improves hypoxic tolerance through upregulation of HIF-1\u03b1. Vascul Pharmacol 83:36\u201346. https:\/\/doi.org\/10.1016\/J.VPH.2016.03.004","journal-title":"Vascul Pharmacol"},{"key":"3691_CR45","doi-asserted-by":"publisher","DOI":"10.1152\/AJPLUNG.2001.281.1.L43","author":"RC Rubenstein","year":"2001","unstructured":"Rubenstein RC, Lyons BM (2001) Sodium 4-phenylbutyrate downregulates HSC70 expression by facilitating mRNA degradation. Am J Physiol Lung Cell Mol Physiol. https:\/\/doi.org\/10.1152\/AJPLUNG.2001.281.1.L43","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3691_CR46","doi-asserted-by":"publisher","first-page":"R87","DOI":"10.1530\/JME-16-0189","volume":"58","author":"E Tubbs","year":"2017","unstructured":"Tubbs E, Rieusset J (2017) Metabolic signaling functions of ER\u2013mitochondria contact sites: role in metabolic diseases. J Mol Endocrinol 58:R87\u2013R106","journal-title":"J Mol Endocrinol"},{"key":"3691_CR47","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-019-0289-8","author":"MF Xia","year":"2019","unstructured":"Xia MF, Zhang YZ, Jin K et al (2019) Communication between mitochondria and other organelles: a brand-new perspective on mitochondria in cancer. Cell Biosci. https:\/\/doi.org\/10.1186\/s13578-019-0289-8","journal-title":"Cell Biosci"},{"key":"3691_CR48","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00172","author":"O Moltedo","year":"2019","unstructured":"Moltedo O, Remondelli P, Amodio G (2019) The mitochondria\u2013endoplasmic reticulum contacts and their critical role in aging and age-associated diseases. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2019.00172","journal-title":"Front Cell Dev Biol"},{"key":"3691_CR49","first-page":"282","volume":"60","author":"Y Mizuno","year":"1993","unstructured":"Mizuno Y, Ikebe S, Hattori N et al (1993) Mitochondrial energy crisis in Parkinson\u2019s disease. Adv Neurol 60:282\u2013287","journal-title":"Adv Neurol"},{"key":"3691_CR50","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/0925-4439(95)00038-6","volume":"1271","author":"Y Mizuno","year":"1995","unstructured":"Mizuno Y, Ikebe S, Hattori N et al (1995) Role of mitochondria in the etiology and pathogenesis of Parkinson\u2019s disease. Biochim Biophys Acta 1271:265\u2013274. https:\/\/doi.org\/10.1016\/0925-4439(95)00038-6","journal-title":"Biochim Biophys Acta"},{"key":"3691_CR51","doi-asserted-by":"publisher","first-page":"461","DOI":"10.3233\/JPD-130230","volume":"3","author":"V Dias","year":"2013","unstructured":"Dias V, Junn E, Mouradian MM (2013) The role of oxidative stress in Parkinson\u2019s disease. J Parkinsons Dis 3:461\u2013491. https:\/\/doi.org\/10.3233\/JPD-130230","journal-title":"J Parkinsons Dis"},{"key":"3691_CR52","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.1089\/ARS.2009.2624","volume":"11","author":"Z Yao","year":"2009","unstructured":"Yao Z, Wood NW (2009) Cell death pathways in Parkinson\u2019s disease: role of mitochondria. Antioxid Redox Signal 11:2135\u20132149. https:\/\/doi.org\/10.1089\/ARS.2009.2624","journal-title":"Antioxid Redox Signal"},{"key":"3691_CR53","doi-asserted-by":"publisher","first-page":"43150","DOI":"10.1074\/JBC.M507124200","volume":"280","author":"W Zhou","year":"2005","unstructured":"Zhou W, Freed CR (2005) DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T alpha-synuclein toxicity. J Biol Chem 280:43150\u201343158. https:\/\/doi.org\/10.1074\/JBC.M507124200","journal-title":"J Biol Chem"},{"key":"3691_CR54","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2010-100363","author":"J Zhu","year":"2010","unstructured":"Zhu J, Chu CT (2010) Mitochondrial dysfunction in Parkinson\u2019s disease. J Alzheimers Dis. https:\/\/doi.org\/10.3233\/JAD-2010-100363","journal-title":"J Alzheimers Dis"},{"key":"3691_CR55","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/J.GENE.2013.07.085","volume":"532","author":"L Zuo","year":"2013","unstructured":"Zuo L, Motherwell MS (2013) The impact of reactive oxygen species and genetic mitochondrial mutations in Parkinson\u2019s disease. Gene 532:18\u201323. https:\/\/doi.org\/10.1016\/J.GENE.2013.07.085","journal-title":"Gene"},{"key":"3691_CR56","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/J.FREERADBIOMED.2008.06.007","volume":"45","author":"AF Domingues","year":"2008","unstructured":"Domingues AF, Ardu\u00edno DM, Esteves AR et al (2008) Mitochondria and ubiquitin-proteasomal system interplay: relevance to Parkinson\u2019s disease. Free Radic Biol Med 45:820\u2013825. https:\/\/doi.org\/10.1016\/J.FREERADBIOMED.2008.06.007","journal-title":"Free Radic Biol Med"},{"key":"3691_CR57","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS20205208","author":"B Cho","year":"2019","unstructured":"Cho B, Kim T, Huh YJ et al (2019) Amelioration of mitochondrial quality control and proteostasis by natural compounds in Parkinson\u2019s disease models. Int J Mol Sci. https:\/\/doi.org\/10.3390\/IJMS20205208","journal-title":"Int J Mol Sci"},{"key":"3691_CR58","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.neures.2018.11.004","volume":"147","author":"A Kato","year":"2019","unstructured":"Kato A, Tatsumi Y, Yako H et al (2019) Recurrent short-term hypoglycemia and hyperglycemia induce apoptosis and oxidative stress via the ER stress response in immortalized adult mouse Schwann (IMS32) cells. Neurosci Res 147:26\u201332. https:\/\/doi.org\/10.1016\/j.neures.2018.11.004","journal-title":"Neurosci Res"},{"key":"3691_CR59","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00302","author":"M Suzuki","year":"2017","unstructured":"Suzuki M, Everett ET, Whitford GM, Bartlett JD (2017) 4-Phenylbutyrate mitigates fluoride-induced cytotoxicity in ALC cells. Front Physiol. https:\/\/doi.org\/10.3389\/fphys.2017.00302","journal-title":"Front Physiol"},{"key":"3691_CR60","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.taap.2010.04.005","volume":"246","author":"ZF Luo","year":"2010","unstructured":"Luo ZF, Feng B, Mu J et al (2010) Effects of 4-phenylbutyric acid on the process and development of diabetic nephropathy induced in rats by streptozotocin: regulation of endoplasmic reticulum stress-oxidative activation. Toxicol Appl Pharmacol 246:49\u201357. https:\/\/doi.org\/10.1016\/j.taap.2010.04.005","journal-title":"Toxicol Appl Pharmacol"},{"key":"3691_CR61","doi-asserted-by":"publisher","DOI":"10.3390\/CELLS9010233","author":"L Sironi","year":"2020","unstructured":"Sironi L, Restelli LM, Tolnay M et al (2020) Dysregulated interorganellar crosstalk of mitochondria in the pathogenesis of Parkinson\u2019s disease. Cells. https:\/\/doi.org\/10.3390\/CELLS9010233","journal-title":"Cells"},{"key":"3691_CR62","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ab.2017.07.009","volume":"552","author":"LD Zorova","year":"2018","unstructured":"Zorova LD, Popkov VA, Plotnikov EY et al (2018) Mitochondrial membrane potential. Anal Biochem 552:50\u201359. https:\/\/doi.org\/10.1016\/j.ab.2017.07.009","journal-title":"Anal Biochem"},{"key":"3691_CR63","doi-asserted-by":"publisher","first-page":"863","DOI":"10.2217\/fca.12.58","volume":"8","author":"KA Webster","year":"2012","unstructured":"Webster KA (2012) Mitochondrial membrane permeabilization and cell death during myocardial infarction: roles of calcium and reactive oxygen species. Future Cardiol 8:863\u2013884","journal-title":"Future Cardiol"},{"key":"3691_CR64","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1089\/dna.2013.2011","volume":"32","author":"T Cal\u00ec","year":"2013","unstructured":"Cal\u00ec T, Ottolini D, Brini M (2013) Calcium and endoplasmic reticulum-mitochondria tethering in neurodegeneration. DNA Cell Biol 32:140\u2013146. https:\/\/doi.org\/10.1089\/dna.2013.2011","journal-title":"DNA Cell Biol"},{"key":"3691_CR65","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.ceca.2017.05.003","volume":"69","author":"S Marchi","year":"2018","unstructured":"Marchi S, Patergnani S, Missiroli S et al (2018) Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death. Cell Calcium 69:62\u201372","journal-title":"Cell Calcium"},{"key":"3691_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms22020946","volume":"22","author":"P Sander","year":"2021","unstructured":"Sander P, Gudermann T, Schredelseker J (2021) A calcium guard in the outer membrane: is vdac a regulated gatekeeper of mitochondrial calcium uptake? Int J Mol Sci 22:1\u201318","journal-title":"Int J Mol Sci"},{"key":"3691_CR67","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/cdd.2011.92","volume":"19","author":"D de Stefani","year":"2012","unstructured":"de Stefani D, Bononi A, Romagnoli A et al (2012) VDAC1 selectively transfers apoptotic Ca 2 signals to mitochondria. Cell Death Differ 19:267\u2013273. https:\/\/doi.org\/10.1038\/cdd.2011.92","journal-title":"Cell Death Differ"},{"key":"3691_CR68","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.ceca.2017.06.007","volume":"69","author":"V Shoshan-Barmatz","year":"2018","unstructured":"Shoshan-Barmatz V, Krelin Y, Shteinfer-Kuzmine A (2018) VDAC1 functions in Ca2+ homeostasis and cell life and death in health and disease. Cell Calcium 69:81\u2013100","journal-title":"Cell Calcium"},{"key":"3691_CR69","doi-asserted-by":"publisher","first-page":"460","DOI":"10.3389\/fphys.2017.00460","volume":"8","author":"AKS Camara","year":"2017","unstructured":"Camara AKS, Zhou YF, Wen PC et al (2017) Mitochondrial VDAC1: a key gatekeeper as potential therapeutic target. Front Physiol 8:460","journal-title":"Front Physiol"},{"key":"3691_CR70","doi-asserted-by":"publisher","first-page":"19870","DOI":"10.1074\/jbc.M112.448290","volume":"288","author":"H Huang","year":"2013","unstructured":"Huang H, Hu X, Eno CO et al (2013) An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake. J Biol Chem 288:19870\u201319881. https:\/\/doi.org\/10.1074\/jbc.M112.448290","journal-title":"J Biol Chem"},{"key":"3691_CR71","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-015-0188-y","author":"Z Liu","year":"2015","unstructured":"Liu Z, Luo Q, Guo C (2015) Bim and VDAC1 are hierarchically essential for mitochondrial ATF2 mediated cell death. Cancer Cell Int. https:\/\/doi.org\/10.1186\/s12935-015-0188-y","journal-title":"Cancer Cell Int"},{"key":"3691_CR72","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1038\/sj.cdd.4401950","volume":"13","author":"C Garrido","year":"2006","unstructured":"Garrido C, Galluzzi L, Brunet M et al (2006) Mechanisms of cytochrome c release from mitochondria. Cell Death Differ 13:1423\u20131433","journal-title":"Cell Death Differ"},{"key":"3691_CR73","doi-asserted-by":"publisher","first-page":"4497","DOI":"10.1073\/pnas.1118244109","volume":"109","author":"C Garcia-Perez","year":"2012","unstructured":"Garcia-Perez C, Roy SS, Naghdi S et al (2012) Bid-induced mitochondrial membrane permeabilization waves propagated by local reactive oxygen species (ROS) signaling. Proc Natl Acad Sci USA 109:4497\u20134502. https:\/\/doi.org\/10.1073\/pnas.1118244109","journal-title":"Proc Natl Acad Sci USA"},{"key":"3691_CR74","doi-asserted-by":"publisher","first-page":"4997","DOI":"10.1073\/pnas.95.9.4997","volume":"95","author":"JM J\u00fcrgensmeier","year":"1998","unstructured":"J\u00fcrgensmeier JM, Xie Z, Deveraux Q et al (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci USA 95:4997\u20135002. https:\/\/doi.org\/10.1073\/pnas.95.9.4997","journal-title":"Proc Natl Acad Sci USA"},{"key":"3691_CR75","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02825-7","author":"M Zhang","year":"2017","unstructured":"Zhang M, Zheng J, Nussinov R, Ma B (2017) Release of cytochrome C from bax pores at the mitochondrial membrane \/631\/114\/2397 \/639\/638\/440\/56 \/119\/118 article. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-017-02825-7","journal-title":"Sci Rep"},{"key":"3691_CR76","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1042\/BJ20111943","volume":"443","author":"S Fernandez-Fernandez","year":"2012","unstructured":"Fernandez-Fernandez S, Almeida A, Bola\u00f1os JP (2012) Antioxidant and bioenergetic coupling between neurons and astrocytes. Biochem J 443:3\u201312. https:\/\/doi.org\/10.1042\/BJ20111943","journal-title":"Biochem J"}],"updated-by":[{"DOI":"10.1007\/s11064-023-03975-z","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000}}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-022-03691-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-022-03691-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-022-03691-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T02:07:31Z","timestamp":1688522851000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-022-03691-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,3]]},"references-count":76,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["3691"],"URL":"https:\/\/doi.org\/10.1007\/s11064-022-03691-0","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s11064-023-03975-z","asserted-by":"object"}]},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,3]]},"assertion":[{"value":"2 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 June 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 August 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2023","order":5,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":6,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s11064-023-03975-z","URL":"https:\/\/doi.org\/10.1007\/s11064-023-03975-z","order":8,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Animals were used after approval by the Institutional animal ethics committee of CSIR \u2013 Central Drug Research Institute (IAEC\/2018\/F-52).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}