{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T07:44:26Z","timestamp":1785656666117,"version":"3.56.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T00:00:00Z","timestamp":1660608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"The National Natural Science Foundation of China Regional Foundation Project","award":["82060400"],"award-info":[{"award-number":["82060400"]}]},{"name":"Gansu Province Youth Science and Technology Fund Project","award":["20JR5RA318"],"award-info":[{"award-number":["20JR5RA318"]}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["lzujbky-2019-sp04"],"award-info":[{"award-number":["lzujbky-2019-sp04"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital","award":["CY2018-QN17"],"award-info":[{"award-number":["CY2018-QN17"]}]},{"name":"Cuiying Scientific Training Program for Undergraduates of Lanzhou University Second Hospital","award":["CYXZ2021-01"],"award-info":[{"award-number":["CYXZ2021-01"]}]},{"name":"Cuiying Scientific Training Program for Undergraduates of Lanzhou University Second Hospital","award":["CYXZ2021-08"],"award-info":[{"award-number":["CYXZ2021-08"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spinal cord injury (SCI) can result in a partial or complete loss of motor and sensory function below the injured segment, which has a significant impact on patients' quality of life and places a significant social burden on them. Long non-coding RNA (LncRNA) is a 200\u20131000\u00a0bp non-coding RNA that has been shown to have a key regulatory role in the progression of a variety of neurological illnesses. Many studies have demonstrated that differentially expressed LncRNAs following spinal cord injury can participate in inflammatory damage, apoptosis, and nerve healing by functioning as competitive endogenous RNA (ceRNA); at the same time, it has a significant regulatory effect on sequelae such neuropathic pain. As a result, we believe that LncRNAs could be useful as a molecular regulatory target in the diagnosis, treatment, and prognosis of spinal cord injury.<\/jats:p>","DOI":"10.1007\/s11064-022-03720-y","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T16:03:08Z","timestamp":1660665788000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Research Progress of Long Non-coding RNAs in Spinal Cord Injury"],"prefix":"10.1007","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4659-664X","authenticated-orcid":false,"given":"Zongyan","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianci","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XueXue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,16]]},"reference":[{"issue":"11","key":"3720_CR1","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.3390\/ijms20112698","volume":"20","author":"F Cofano","year":"2019","unstructured":"Cofano F, Boido M, Monticelli M, Zenga F, Ducati A, Vercelli A, Garbossa D (2019) Mesenchymal stem cells for spinal cord injury: current options, limitations, and future of cell therapy. Int J Mol Sci 20(11):2698. https:\/\/doi.org\/10.3390\/ijms20112698","journal-title":"Int J Mol Sci"},{"issue":"12","key":"3720_CR2","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1002\/sctm.19-0135","volume":"9","author":"CS Ahuja","year":"2020","unstructured":"Ahuja CS, Mothe A, Khazaei M, Badhiwala JH, Gilbert EA, van der Kooy D, Morshead CM, Tator C, Fehlings MG (2020) The leading edge: emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury. Stem Cells Transl Med 9(12):1509\u20131530. https:\/\/doi.org\/10.1002\/sctm.19-0135","journal-title":"Stem Cells Transl Med"},{"issue":"9","key":"3720_CR3","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1016\/j.molmed.2017.07.005","volume":"23","author":"I Vismara","year":"2017","unstructured":"Vismara I, Papa S, Rossi F, Forloni G, Veglianese P (2017) Current options for cell therapy in spinal cord injury. Trends Mol Med 23(9):831\u2013849. https:\/\/doi.org\/10.1016\/j.molmed.2017.07.005","journal-title":"Trends Mol Med"},{"issue":"20","key":"3720_CR4","doi-asserted-by":"publisher","first-page":"7533","DOI":"10.3390\/ijms21207533","volume":"21","author":"A Anjum","year":"2020","unstructured":"Anjum A, Yazid MD, Fauzi Daud M, Idris J, Ng AMH, Selvi Naicker A, Ismail OHR, Athi Kumar RK, Lokanathan Y (2020) Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms. Int J Mol Sci 21(20):7533. https:\/\/doi.org\/10.3390\/ijms21207533","journal-title":"Int J Mol Sci"},{"key":"3720_CR5","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.jchemneu.2017.08.001","volume":"87","author":"E Hayta","year":"2018","unstructured":"Hayta E, Elden H (2018) Acute spinal cord injury: a review of pathophysiology and potential of non-steroidal anti-inflammatory drugs for pharmacological intervention. J Chem Neuroanat 87:25\u201331. https:\/\/doi.org\/10.1016\/j.jchemneu.2017.08.001","journal-title":"J Chem Neuroanat"},{"issue":"14","key":"3720_CR6","doi-asserted-by":"publisher","first-page":"7435","DOI":"10.3390\/ijms22147435","volume":"22","author":"H Suzuki","year":"2021","unstructured":"Suzuki H, Sakai T (2021) Current concepts of stem cell therapy for chronic spinal cord injury. Int J Mol Sci 22(14):7435. https:\/\/doi.org\/10.3390\/ijms22147435","journal-title":"Int J Mol Sci"},{"issue":"2","key":"3720_CR7","doi-asserted-by":"publisher","first-page":"e202009045","DOI":"10.1083\/jcb.202009045","volume":"220","author":"MC Bridges","year":"2021","unstructured":"Bridges MC, Daulagala AC, Kourtidis A (2021) LNCcation: lncRNA localization and function. J Cell Biol 220(2):e202009045. https:\/\/doi.org\/10.1083\/jcb.202009045","journal-title":"J Cell Biol"},{"issue":"9","key":"3720_CR8","doi-asserted-by":"publisher","first-page":"e60583","DOI":"10.7554\/eLife.60583","volume":"23","author":"T Ali","year":"2020","unstructured":"Ali T, Grote P (2020) Beyond the RNA-dependent function of LncRNA genes. Elife 23(9):e60583. https:\/\/doi.org\/10.7554\/eLife.60583","journal-title":"Elife"},{"issue":"6","key":"3720_CR9","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1038\/s41580-019-0114-6","volume":"20","author":"B van Steensel","year":"2019","unstructured":"van Steensel B, Furlong EEM (2019) The role of transcription in shaping the spatial organization of the genome. Nat Rev Mol Cell Biol 20(6):327\u2013337. https:\/\/doi.org\/10.1038\/s41580-019-0114-6","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"3720_CR10","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1093\/bib\/bbv031","volume":"17","author":"F Ferr\u00e8","year":"2016","unstructured":"Ferr\u00e8 F, Colantoni A, Helmer-Citterich M (2016) Revealing protein-lncRNA interaction. Brief Bioinform 17(1):106\u2013116. https:\/\/doi.org\/10.1093\/bib\/bbv031","journal-title":"Brief Bioinform"},{"issue":"2","key":"3720_CR11","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1002\/cac2.12108","volume":"41","author":"YT Tan","year":"2021","unstructured":"Tan YT, Lin JF, Li T, Li JJ, Xu RH, Ju HQ (2021) LncRNA-mediated posttranslational modifications and reprogramming of energy metabolism in cancer. Cancer Commun (Lond) 41(2):109\u2013120. https:\/\/doi.org\/10.1002\/cac2.12108","journal-title":"Cancer Commun (Lond)"},{"key":"3720_CR12","doi-asserted-by":"publisher","first-page":"116900","DOI":"10.1016\/j.lfs.2019.116900","volume":"254","author":"Z Zhao","year":"2020","unstructured":"Zhao Z, Sun W, Guo Z, Zhang J, Yu H, Liu B (2020) Mechanisms of lncRNA\/microRNA interactions in angiogenesis. Life Sci 254:116900. https:\/\/doi.org\/10.1016\/j.lfs.2019.116900","journal-title":"Life Sci"},{"issue":"1","key":"3720_CR13","doi-asserted-by":"publisher","first-page":"e12951","DOI":"10.1111\/cpr.12951","volume":"54","author":"W Wang","year":"2021","unstructured":"Wang W, Li J, Zhang Z, Ma H, Li Q, Yang H, Li M, Liu L (2021) Genome-wide analysis of acute traumatic spinal cord injury-related RNA expression profiles and uncovering of a regulatory axis in spinal fibrotic scars. Cell Prolif 54(1):e12951. https:\/\/doi.org\/10.1111\/cpr.12951","journal-title":"Cell Prolif"},{"issue":"1","key":"3720_CR14","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/s41418-019-0351-4","volume":"27","author":"P Wan","year":"2020","unstructured":"Wan P, Su W, Zhang Y, Li Z, Deng C, Li J, Jiang N, Huang S, Long E, Zhuo Y (2020) LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia\/reperfusion injury. Cell Death Differ 27(1):176\u2013191. https:\/\/doi.org\/10.1038\/s41418-019-0351-4","journal-title":"Cell Death Differ"},{"issue":"1","key":"3720_CR15","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s12640-020-00202-3","volume":"38","author":"L Guan","year":"2020","unstructured":"Guan L, Li T, Jiang J (2020) Bupivacaine-induced neurotoxicity is modulated by epigenetic axis of long noncoding RNA SNHG16 and Hsa-miR-132-3p. Neurotox Res 38(1):175\u2013183. https:\/\/doi.org\/10.1007\/s12640-020-00202-3","journal-title":"Neurotox Res"},{"issue":"13","key":"3720_CR16","doi-asserted-by":"publisher","first-page":"7460","DOI":"10.1111\/jcmm.15368","volume":"24","author":"Y Ma","year":"2020","unstructured":"Ma Y, Zhai D, Zhang W, Zhang H, Dong L, Zhou Y, Feng D, Zheng Y, Wang T, Mao C, Wang X (2020) Down-regulation of long non-coding RNA MEG3 promotes Schwann cell proliferation and migration and repairs sciatic nerve injury in rats. J Cell Mol Med 24(13):7460\u20137469. https:\/\/doi.org\/10.1111\/jcmm.15368","journal-title":"J Cell Mol Med"},{"issue":"1","key":"3720_CR17","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1186\/s12885-019-5983-8","volume":"19","author":"RS Zhou","year":"2019","unstructured":"Zhou RS, Zhang EX, Sun QF, Ye ZJ, Liu JW, Zhou DH, Tang Y (2019) Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue. BMC Cancer 19(1):779. https:\/\/doi.org\/10.1186\/s12885-019-5983-8","journal-title":"BMC Cancer"},{"issue":"10","key":"3720_CR18","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.554759","volume":"15","author":"X Wu","year":"2020","unstructured":"Wu X, Sui Z, Zhang H, Wang Y, Yu Z (2020) Integrated analysis of lncRNA-mediated ceRNA network in lung adenocarcinoma. Front Oncol 15(10):554759. https:\/\/doi.org\/10.3389\/fonc.2020.554759","journal-title":"Front Oncol"},{"issue":"4","key":"3720_CR19","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.3892\/mmr.2019.9979","volume":"19","author":"L Wang","year":"2019","unstructured":"Wang L, Wang B, Liu J, Quan Z (2019) Construction and analysis of a spinal cord injury competitive endogenous RNA network based on the expression data of long noncoding, micro-and messenger RNAs. Mol Med Rep 19(4):3021\u20133034. https:\/\/doi.org\/10.3892\/mmr.2019.9979","journal-title":"Mol Med Rep"},{"key":"3720_CR20","doi-asserted-by":"publisher","first-page":"144171","DOI":"10.1016\/j.gene.2019.144171","volume":"726","author":"N Wang","year":"2020","unstructured":"Wang N, He L, Yang Y, Li S, Chen Y, Tian Z, Ji Y, Wang Y, Pang M, Wang Y, Liu B, Rong L (2020) Integrated analysis of competing endogenous RNA (ceRNA) networks in subacute stage of spinal cord injury. Gene 726:144171. https:\/\/doi.org\/10.1016\/j.gene.2019.144171","journal-title":"Gene"},{"key":"3720_CR21","doi-asserted-by":"publisher","DOI":"10.1002\/jor.25101","author":"W Wang","year":"2021","unstructured":"Wang W, Ma L, Li J, Yang SY, Yi Z, Sun M, Chen J, Xie W (2021) Identification and coregulation pattern analysis of long noncoding RNAs following subacute spinal cord injury. J Orthop Res. https:\/\/doi.org\/10.1002\/jor.25101","journal-title":"J Orthop Res"},{"issue":"7","key":"3720_CR22","doi-asserted-by":"publisher","first-page":"41008","DOI":"10.1038\/srep41008.PMID:28106101","volume":"20","author":"RC Duran","year":"2017","unstructured":"Duran RC, Yan H, Zheng Y, Huang X, Grill R, Kim DH, Cao Q, Wu JQ (2017) The systematic analysis of coding and long non-coding RNAs in the sub-chronic and chronic stages of spinal cord injury. Sci Rep 20(7):41008. https:\/\/doi.org\/10.1038\/srep41008.PMID:28106101","journal-title":"Sci Rep"},{"issue":"3","key":"3720_CR23","doi-asserted-by":"publisher","first-page":"405","DOI":"10.4103\/1673-5374.293130","volume":"16","author":"XC Hu","year":"2021","unstructured":"Hu XC, Lu YB, Yang YN, Kang XW, Wang YG, Ma B, Xing S (2021) Progress in clinical trials of cell transplantation for the treatment of spinal cord injury: how many questions remain unanswered? Neural Regen Res 16(3):405\u2013413. https:\/\/doi.org\/10.4103\/1673-5374.293130","journal-title":"Neural Regen Res"},{"issue":"6","key":"3720_CR24","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1007\/s12031-020-01740-3","volume":"71","author":"G Bai","year":"2021","unstructured":"Bai G, Jiang L, Meng P, Li J, Han C, Wang Y, Wang Q (2021) LncRNA Neat1 promotes regeneration after spinal cord injury by targeting miR-29b. J Mol Neurosci 71(6):1174\u20131184. https:\/\/doi.org\/10.1007\/s12031-020-01740-3","journal-title":"J Mol Neurosci"},{"issue":"1","key":"3720_CR25","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1186\/s13287-019-1487-3","volume":"10","author":"Y Cui","year":"2019","unstructured":"Cui Y, Yin Y, Xiao Z, Zhao Y, Chen B, Yang B, Xu B, Song H, Zou Y, Ma X, Dai J (2019) LncRNA Neat1 mediates miR-124-induced activation of Wnt\/\u03b2-catenin signaling in spinal cord neural progenitor cells. Stem Cell Res Ther 10(1):400. https:\/\/doi.org\/10.1186\/s13287-019-1487-3","journal-title":"Stem Cell Res Ther"},{"key":"3720_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134649","author":"Q Zhao","year":"2020","unstructured":"Zhao Q, Lu F, Su Q, Liu Z, Xia X, Yan Z, Zhou F, Qin R (2020) Knockdown of long noncoding RNA XIST mitigates the apoptosis and inflammatory injury of microglia cells after spinal cord injury through miR-27a\/Smurf1 axis. Neurosci Lett. https:\/\/doi.org\/10.1016\/j.neulet.2019.134649","journal-title":"Neurosci Lett"},{"issue":"1","key":"3720_CR27","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1515\/med-2021-0292","volume":"16","author":"X Zhong","year":"2021","unstructured":"Zhong X, Bao Y, Wu Q, Xi X, Zhu W, Chen S, Liao J (2021) Long noncoding RNA XIST knockdown relieves the injury of microglia cells after spinal cord injury by sponging miR-219-5p. Open Med (Wars) 16(1):1090\u20131100. https:\/\/doi.org\/10.1515\/med-2021-0292","journal-title":"Open Med (Wars)"},{"issue":"4","key":"3720_CR28","doi-asserted-by":"publisher","first-page":"732","DOI":"10.3390\/ijms18040732","volume":"18","author":"S Gu","year":"2017","unstructured":"Gu S, Xie R, Liu X, Shou J, Gu W, Che X (2017) Long coding RNA XIST contributes to neuronal apoptosis through the downregulation of AKT phosphorylation and is negatively regulated by miR-494 in rat spinal cord injury. Int J Mol Sci 18(4):732. https:\/\/doi.org\/10.3390\/ijms18040732","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3720_CR29","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1515\/tnsci-2021-0013","volume":"12","author":"X Li","year":"2021","unstructured":"Li X, Qian Y, Tang K, Li Y, Tao R, Gong C, Huang L, Zou K, Liu L (2021) Inhibition of lncRNA H19\/miR-370-3p pathway mitigates neuronal apoptosis in an in vitro model of spinal cord injury (SCI). Transl Neurosci 12(1):103\u2013113. https:\/\/doi.org\/10.1515\/tnsci-2021-0013","journal-title":"Transl Neurosci"},{"issue":"10","key":"3720_CR30","doi-asserted-by":"publisher","first-page":"844","DOI":"10.21037\/atm-21-1526","volume":"9","author":"X Geng","year":"2021","unstructured":"Geng X, Zou Y, Li S, Qi R, Jing C, Ding X, Li J, Yu H (2021) Electroacupuncture promotes the recovery of rats with spinal cord injury by suppressing the Notch signaling pathway via the H19\/EZH2 axis. Ann Transl Med 9(10):844. https:\/\/doi.org\/10.21037\/atm-21-1526","journal-title":"Ann Transl Med"},{"issue":"6","key":"3720_CR31","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1007\/s12031-020-01751-0","volume":"71","author":"E Gu","year":"2021","unstructured":"Gu E, Pan W, Chen K, Zheng Z, Chen G, Cai P (2021) LncRNA H19 regulates lipopolysaccharide (LPS)-Induced apoptosis and inflammation of BV2 microglia cells through targeting miR-325-3p\/NEUROD4 axis. J Mol Neurosci 71(6):1256\u20131265. https:\/\/doi.org\/10.1007\/s12031-020-01751-0","journal-title":"J Mol Neurosci"},{"key":"3720_CR32","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.semcdb.2019.05.004","volume":"94","author":"CS Subhramanyam","year":"2019","unstructured":"Subhramanyam CS, Wang C, Hu Q, Dheen ST (2019) Microglia-mediated neuroinflammation in neurodegenerative diseases. Semin Cell Dev Biol 94:112\u2013120. https:\/\/doi.org\/10.1016\/j.semcdb.2019.05.004","journal-title":"Semin Cell Dev Biol"},{"issue":"2","key":"3720_CR33","doi-asserted-by":"publisher","first-page":"113","DOI":"10.5114\/fn.2020.96755","volume":"58","author":"D Hernandez Baltazar","year":"2020","unstructured":"Hernandez Baltazar D, Nadella R, Barrientos Bonilla A, Flores Mart\u00ednez Y, Olgu\u00edn A, Heman Bozadas P, Rovirosa Hern\u00e1ndez M, Cibri\u00e1n LI (2020) Does lipopolysaccharide-based neuroinflammation induce microglia polarization? Folia Neuropathol 58(2):113\u2013122. https:\/\/doi.org\/10.5114\/fn.2020.96755","journal-title":"Folia Neuropathol"},{"issue":"11","key":"3720_CR34","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1038\/ni.2109","volume":"12","author":"SJ Galli","year":"2011","unstructured":"Galli SJ, Borregaard N, Wynn TA (2011) Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol 12(11):1035\u20131044. https:\/\/doi.org\/10.1038\/ni.2109","journal-title":"Nat Immunol"},{"issue":"1","key":"3720_CR35","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s12974-020-01805-5","volume":"17","author":"J Zhou","year":"2020","unstructured":"Zhou J, Li Z, Wu T, Zhao Q, Zhao Q, Cao Y (2020) LncGBP9\/miR-34a axis drives macrophages toward a phenotype conducive for spinal cord injury repair via STAT1\/STAT6 and SOCS3. J Neuroinflammation 17(1):134. https:\/\/doi.org\/10.1186\/s12974-020-01805-5","journal-title":"J Neuroinflammation"},{"issue":"4","key":"3720_CR36","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1007\/s10753-020-01230-z","volume":"43","author":"M Shao","year":"2020","unstructured":"Shao M, Jin M, Xu S, Zheng C, Zhu W, Ma X, Lv F (2020) Exosomes from long noncoding RNA-Gm37494-ADSCs repair spinal cord injury via shifting microglial M1\/M2 polarization. Inflammation 43(4):1536\u20131547. https:\/\/doi.org\/10.1007\/s10753-020-01230-z","journal-title":"Inflammation"},{"issue":"4","key":"3720_CR37","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.neuron.2020.08.012","volume":"108","author":"M Linnerbauer","year":"2020","unstructured":"Linnerbauer M, Wheeler MA, Quintana FJ (2020) Astrocyte crosstalk in CNS inflammation. Neuron 108(4):608\u2013622. https:\/\/doi.org\/10.1016\/j.neuron.2020.08.012","journal-title":"Neuron"},{"key":"3720_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2020.155106","volume":"131","author":"P Li","year":"2020","unstructured":"Li P, Li Y, Dai Y, Wang B, Li L, Jiang B, Wu P, Xu J (2020) The LncRNA H19\/miR-1-3p\/CCL2 axis modulates lipopolysaccharide (LPS) stimulation-induced normal human astrocyte proliferation and activation. Cytokine 131:155106. https:\/\/doi.org\/10.1016\/j.cyto.2020.155106","journal-title":"Cytokine"},{"issue":"1","key":"3720_CR39","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s12974-021-02156-5","volume":"18","author":"X Liu","year":"2021","unstructured":"Liu X, Zhou F, Wang W, Chen G, Zhang Q, Lv R, Zhao Z, Li X, Yu Q, Meves JM, Hua H, Li X, Wang X, Sun H, Gao D (2021) IL-9-triggered lncRNA Gm13568 regulates Notch1 in astrocytes through interaction with CBP\/P300: contribute to the pathogenesis of experimental autoimmune encephalomyelitis. J Neuroinflammation 18(1):108. https:\/\/doi.org\/10.1186\/s12974-021-02156-5","journal-title":"J Neuroinflammation"},{"issue":"8","key":"3720_CR40","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1007\/s10571-020-00824-3","volume":"40","author":"X Xia","year":"2020","unstructured":"Xia X, Niu H, Ma Y, Qu B, He M, Yu K, Wang E, Zhang L, Gu J, Liu G (2020) LncRNA CCAT1 protects astrocytes against OGD\/R-induced damage by targeting the miR-218\/NFAT5-signaling axis. Cell Mol Neurobiol 40(8):1383\u20131393. https:\/\/doi.org\/10.1007\/s10571-020-00824-3","journal-title":"Cell Mol Neurobiol"},{"key":"3720_CR41","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bbi.2020.12.013","volume":"93","author":"E Schmidt","year":"2021","unstructured":"Schmidt E, Raposo P, Vavrek R, Fouad K (2021) Inducing inflammation following subacute spinal cord injury in female rats: A double-edged sword to promote motor recovery. Brain Behav Immun 93:55\u201365. https:\/\/doi.org\/10.1016\/j.bbi.2020.12.013","journal-title":"Brain Behav Immun"},{"issue":"1","key":"3720_CR42","doi-asserted-by":"publisher","first-page":"152033","DOI":"10.1016\/j.imbio.2020.152033","volume":"226","author":"A Al Mamun","year":"2021","unstructured":"Al Mamun A, Monalisa I, Tul Kubra K, Akter A, Akter J, Sarker T, Munir F, Wu Y, Jia C, Afrin Taniya M, Xiao J (2021) Advances in immunotherapy for the treatment of spinal cord injury. Immunobiology 226(1):152033. https:\/\/doi.org\/10.1016\/j.imbio.2020.152033","journal-title":"Immunobiology"},{"key":"3720_CR43","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-021-00793-1","author":"H Li","year":"2021","unstructured":"Li H, Xu Y, Wang G, Chen X, Liang W, Ni H (2021) Editorial expression of concern: long non-coding RNA Mirt2 relieves lipopolysaccharide-induced injury in PC12 cells by suppressing miR-429. J Physiol Biochem. https:\/\/doi.org\/10.1007\/s13105-021-00793-1","journal-title":"J Physiol Biochem"},{"key":"3720_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2019.104287","volume":"110","author":"H Zheng","year":"2019","unstructured":"Zheng H, Hu S, Cao J, Yao L, Zhang N (2019) Long non-coding RNA TUG1 alleviates LPS-induced injury of PC-12 cells by down-regulating microRNA-127. Exp Mol Pathol 110:104287. https:\/\/doi.org\/10.1016\/j.yexmp.2019.104287","journal-title":"Exp Mol Pathol"},{"issue":"4","key":"3720_CR45","doi-asserted-by":"publisher","first-page":"772","DOI":"10.4103\/1673-5374.295335","volume":"16","author":"T Zhang","year":"2021","unstructured":"Zhang T, Li K, Zhang ZL, Gao K, Lv CL (2021) LncRNA airsci increases the inflammatory response after spinal cord injury in rats through the nuclear factor kappa B signaling pathway. Neural Regen Res 16(4):772\u2013777. https:\/\/doi.org\/10.4103\/1673-5374.295335","journal-title":"Neural Regen Res"},{"issue":"8","key":"3720_CR46","doi-asserted-by":"publisher","first-page":"14259","DOI":"10.1002\/jcp.28124","volume":"234","author":"Y Su","year":"2019","unstructured":"Su Y, Zong S, Wei C, Song F, Feng H, Qin A, Lian Z, Fu F, Shao S, Fang F, Wu T, Xu J, Liu Q, Zhao J (2019) Salidroside promotes rat spinal cord injury recovery by inhibiting inflammatory cytokine expression and NF-\u03baB and MAPK signaling pathways. J Cell Physiol 234(8):14259\u201314269. https:\/\/doi.org\/10.1002\/jcp.28124","journal-title":"J Cell Physiol"},{"issue":"11","key":"3720_CR47","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1080\/09168451.2019.1637245","volume":"83","author":"S Zhu","year":"2019","unstructured":"Zhu S, Zhou Z, Li Z, Shao J, Jiao G, Huang YE, Lin Y (2019) Suppression of LINC00707 alleviates lipopolysaccharide-induced inflammation and apoptosis in PC-12 cells by regulated miR-30a-5p\/Neurod 1. Biosci Biotechnol Biochem 83(11):2049\u20132056. https:\/\/doi.org\/10.1080\/09168451.2019.1637245","journal-title":"Biosci Biotechnol Biochem"},{"issue":"1","key":"3720_CR48","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.1080\/21655979.2021.1930925","volume":"12","author":"Q An","year":"2021","unstructured":"An Q, Zhou Z, Xie Y, Sun Y, Zhang H, Cao Y (2021) Knockdown of long non-coding RNA NEAT1 relieves the inflammatory response of spinal cord injury through targeting miR-211-5p\/MAPK1 axis. Bioengineered 12(1):2702\u20132712. https:\/\/doi.org\/10.1080\/21655979.2021.1930925","journal-title":"Bioengineered"},{"issue":"15","key":"3720_CR49","doi-asserted-by":"publisher","first-page":"646788","DOI":"10.3389\/fncel.2021.646788","volume":"14","author":"Y Cao","year":"2021","unstructured":"Cao Y, Jiang C, Lin H, Chen Z (2021) Silencing of long noncoding RNA growth arrest-specific 5 alleviates neuronal cell apoptosis and inflammatory responses through sponging microRNA-93 to repress PTEN expression in spinal cord injury. Front Cell Neurosci 14(15):646788. https:\/\/doi.org\/10.3389\/fncel.2021.646788","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"3720_CR50","doi-asserted-by":"publisher","first-page":"217","DOI":"10.4103\/1673-5374.314322","volume":"17","author":"XM Zhang","year":"2022","unstructured":"Zhang XM, Zeng LN, Yang WY, Ding L, Chen KZ, Fu WJ, Zeng SQ, Liang YR, Chen GH, Wu HF (2022) Inhibition of LncRNA Vof-16 expression promotes nerve regeneration and functional recovery after spinal cord injury. Neural Regen Res 17(1):217\u2013227. https:\/\/doi.org\/10.4103\/1673-5374.314322","journal-title":"Neural Regen Res"},{"issue":"5","key":"3720_CR51","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3892\/etm.2021.9928","volume":"21","author":"H Jiang","year":"2021","unstructured":"Jiang H, Ni J, Zheng Y, Xu Y (2021) Knockdown of lncRNA SNHG14 alleviates LPS-induced inflammation and apoptosis of PC12 cells by regulating miR-181b-5p. Exp Ther Med 21(5):497. https:\/\/doi.org\/10.3892\/etm.2021.9928","journal-title":"Exp Ther Med"},{"issue":"9","key":"3720_CR52","doi-asserted-by":"publisher","first-page":"3259","DOI":"10.1172\/JCI90608","volume":"127","author":"TM O'Shea","year":"2017","unstructured":"O\u2019Shea TM, Burda JE, Sofroniew MV (2017) Cell biology of spinal cord injury and repair. J Clin Invest 127(9):3259\u20133270. https:\/\/doi.org\/10.1172\/JCI90608","journal-title":"J Clin Invest"},{"key":"3720_CR53","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.jchemneu.2017.11.001","volume":"88","author":"J Hota","year":"2018","unstructured":"Hota J, Pati SS, Mahapatra PK (2018) Spinal cord self-repair during tail regeneration in Polypedates maculatus and putative role of FGF1 as a neurotrophic factor. J Chem Neuroanat 88:70\u201375. https:\/\/doi.org\/10.1016\/j.jchemneu.2017.11.001","journal-title":"J Chem Neuroanat"},{"issue":"3","key":"3720_CR54","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.bbrc.2017.06.145","volume":"490","author":"HR Lv","year":"2017","unstructured":"Lv HR (2017) lncRNA-Map2k4 sequesters miR-199a to promote FGF1 expression and spinal cord neuron growth. Biochem Biophys Res Commun 490(3):948\u2013954. https:\/\/doi.org\/10.1016\/j.bbrc.2017.06.145","journal-title":"Biochem Biophys Res Commun"},{"issue":"22","key":"3720_CR55","doi-asserted-by":"publisher","first-page":"7614","DOI":"10.26355\/eurrev_201811_16375","volume":"22","author":"JW Li","year":"2018","unstructured":"Li JW, Kuang Y, Chen L, Wang JF (2018) LncRNA ZNF667-AS1 inhibits inflammatory response and promotes recovery of spinal cord injury via suppressing JAK-STAT pathway. Eur Rev Med Pharmacol Sci 22(22):7614\u20137620. https:\/\/doi.org\/10.26355\/eurrev_201811_16375","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"3720_CR56","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1177\/1535370219895491","volume":"245","author":"D Zhong","year":"2020","unstructured":"Zhong D, Cao Y, Li CJ, Li M, Rong ZJ, Jiang L, Guo Z, Lu HB, Hu JZ (2020) Neural stem cell-derived exosomes facilitate spinal cord functional recovery after injury by promoting angiogenesis. Exp Biol Med (Maywood) 245(1):54\u201365. https:\/\/doi.org\/10.1177\/1535370219895491","journal-title":"Exp Biol Med (Maywood)"},{"issue":"5","key":"3720_CR57","doi-asserted-by":"publisher","first-page":"887","DOI":"10.4103\/1673-5374.232484","volume":"13","author":"T Wang","year":"2018","unstructured":"Wang T, Fang X, Yin ZS (2018) Endothelial progenitor cell-conditioned medium promotes angiogenesis and is neuroprotective after spinal cord injury. Neural Regen Res 13(5):887\u2013895. https:\/\/doi.org\/10.4103\/1673-5374.232484","journal-title":"Neural Regen Res"},{"issue":"8","key":"3720_CR58","doi-asserted-by":"publisher","first-page":"744","DOI":"10.3389\/fcell.2020.00744","volume":"6","author":"X Cheng","year":"2020","unstructured":"Cheng X, Xu J, Yu Z, Xu J, Long H (2020) LncRNA Xist contributes to endogenous neurological repair after chronic compressive spinal cord injury by promoting angiogenesis through the miR-32-5p\/Notch-1 axis. Front Cell Dev Biol 6(8):744. https:\/\/doi.org\/10.3389\/fcell.2020.00744","journal-title":"Front Cell Dev Biol"},{"issue":"6","key":"3720_CR59","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1093\/intimm\/dxaa077","volume":"33","author":"H Tsujioka","year":"2021","unstructured":"Tsujioka H, Yamashita T (2021) Neural circuit repair after central nervous system injury. Int Immunol 33(6):301\u2013309. https:\/\/doi.org\/10.1093\/intimm\/dxaa077","journal-title":"Int Immunol"},{"issue":"7","key":"3720_CR60","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1007\/s10571-020-00803-8","volume":"40","author":"Y Zuo","year":"2020","unstructured":"Zuo Y, Sun H, Song L, Hu Y, Guo F (2020) LncRNA FTX Involves in the Nogo-66-induced inhibition of neurite outgrowth through regulating PDK1\/PKB\/GSK-3\u03b2 pathway. Cell Mol Neurobiol 40(7):1143\u20131153. https:\/\/doi.org\/10.1007\/s10571-020-00803-8","journal-title":"Cell Mol Neurobiol"},{"key":"3720_CR61","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.neures.2017.10.004","volume":"126","author":"S Okada","year":"2018","unstructured":"Okada S, Hara M, Kobayakawa K, Matsumoto Y, Nakashima Y (2018) Astrocyte reactivity and astrogliosis after spinal cord injury. Neurosci Res 126:39\u201343. https:\/\/doi.org\/10.1016\/j.neures.2017.10.004","journal-title":"Neurosci Res"},{"issue":"14","key":"3720_CR62","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fncel.2020.00078","volume":"3","author":"T Yang","year":"2020","unstructured":"Yang T, Dai Y, Chen G, Cui S (2020) Dissecting the dual role of the glial scar and scar-forming astrocytes in spinal cord injury. Front Cell Neurosci 3(14):78","journal-title":"Front Cell Neurosci"},{"issue":"6","key":"3720_CR63","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1042\/BSR20180895","volume":"38","author":"Y He","year":"2018","unstructured":"He Y, Li M, Wujisiguleng LB, Huan Y, Liu B, Wang D, Yu H, Zhang L, Shi Z (2018) Zhenbao Pill reduces Treg cell proportion in acute spinal cord injury rats by regulating TUG1\/miR-214\/HSP27 axis. Biosci Rep 38(6):5","journal-title":"Biosci Rep"},{"issue":"7","key":"3720_CR64","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1002\/2211-5463.12651","volume":"9","author":"XD Ren","year":"2019","unstructured":"Ren XD, Wan CX, Niu YL (2019) Overexpression of lncRNA TCTN2 protects neurons from apoptosis by enhancing cell autophagy in spinal cord injury. FEBS Open Bio 9(7):1223\u20131231. https:\/\/doi.org\/10.1002\/2211-5463.12651","journal-title":"FEBS Open Bio"},{"issue":"11","key":"3720_CR65","doi-asserted-by":"publisher","first-page":"931","DOI":"10.21037\/atm-21-2570","volume":"9","author":"R Shao","year":"2021","unstructured":"Shao R, Li C, Chen Y, Zhang L, Yang H, Zhang Z, Yue J, Gao W, Zhu H, Pan H, Zhou H, Quan R (2021) LncRNA-GAS5 promotes spinal cord repair and the inhibition of neuronal apoptosis via the transplantation of 3D printed scaffold loaded with induced pluripotent stem cell-derived neural stem cells. Ann Transl Med 9(11):931. https:\/\/doi.org\/10.21037\/atm-21-2570","journal-title":"Ann Transl Med"},{"issue":"8","key":"3720_CR66","first-page":"3696","volume":"9","author":"J Zheng","year":"2017","unstructured":"Zheng J, Yi D, Liu Y, Wang M, Zhu Y, Shi H (2017) Long nonding RNA UCA1 regulates neural stem cell differentiation by controlling miR-1\/Hes1 expression. Am J Transl Res. 9(8):3696\u20133704","journal-title":"Am J Transl Res."},{"issue":"3","key":"3720_CR67","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s13311-018-0633-4","volume":"15","author":"R Shiao","year":"2018","unstructured":"Shiao R, Lee-Kubli CA (2018) Neuropathic pain after spinal cord injury: challenges and research perspectives. Neurotherapeutics 15(3):635\u2013653. https:\/\/doi.org\/10.1007\/s13311-018-0633-4","journal-title":"Neurotherapeutics"},{"issue":"23","key":"3720_CR68","doi-asserted-by":"publisher","first-page":"12034","DOI":"10.26355\/eurrev_202012_23992","volume":"24","author":"JY Zhang","year":"2020","unstructured":"Zhang JY, Lv DB, Su YN, Wang XL, Sheng WC, Yang G, Li LX, Gao X, Gao YZ, Li JT (2020) LncRNA SNHG1 attenuates neuropathic pain following spinal cord injury by regulating CDK4 level. Eur Rev Med Pharmacol Sci 24(23):12034\u201312040. https:\/\/doi.org\/10.26355\/eurrev_202012_23992","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"2020","key":"3720_CR69","first-page":"2094948","volume":"6","author":"X Pan","year":"2020","unstructured":"Pan X, Shen C, Huang Y, Wang L, Xia Z (2020) Loss of SNHG4 attenuated spinal nerve ligation-triggered neuropathic pain through sponging miR-423-5p. Mediators Inflamm 6(2020):2094948","journal-title":"Mediators Inflamm"},{"issue":"13","key":"3720_CR70","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3389\/fncel.2019.00050","volume":"20","author":"JZ Hu","year":"2019","unstructured":"Hu JZ, Rong ZJ, Li M, Li P, Jiang LY, Luo ZX, Duan CY, Cao Y, Lu HB (2019) Silencing of lncRNA PKIA-AS1 attenuates spinal nerve ligation-induced neuropathic pain through epigenetic downregulation of CDK6 expression. Front Cell Neurosci 20(13):50. https:\/\/doi.org\/10.3389\/fncel.2019.00050","journal-title":"Front Cell Neurosci"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-022-03720-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-022-03720-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-022-03720-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,6]],"date-time":"2023-01-06T05:29:36Z","timestamp":1672982976000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-022-03720-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,16]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["3720"],"URL":"https:\/\/doi.org\/10.1007\/s11064-022-03720-y","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,16]]},"assertion":[{"value":"9 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 July 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}