{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:18:23Z","timestamp":1791919103078,"version":"4.3.4"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1007\/s11064-022-03788-6","type":"journal-article","created":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T15:03:03Z","timestamp":1667314983000},"page":"625-640","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Traumatic Brain Injury-Mediated Neuroinflammation and Neurological Deficits are Improved by 8-Methoxypsoralen Through Modulating PPAR\u03b3\/NF-\u03baB Pathway"],"prefix":"10.1007","volume":"48","author":[{"given":"Yuzuo","family":"Hui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,1]]},"reference":[{"issue":"6","key":"3788_CR1","doi-asserted-by":"publisher","first-page":"e39357","DOI":"10.1371\/journal.pone.0039357","volume":"7","author":"Z Hu","year":"2012","unstructured":"Hu Z, Yu D, Almeida-Suhett C, Tu K, Marini AM, Eiden L, Braga MF, Zhu J, Li Z (2012) Expression of miRNAs and their cooperative regulation of the pathophysiology in traumatic brain injury. PLoS ONE 7(6):e39357","journal-title":"PLoS ONE"},{"issue":"1","key":"3788_CR2","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1186\/s12974-016-0738-9","volume":"13","author":"F Corrigan","year":"2016","unstructured":"Corrigan F, Mander KA, Leonard AV, Vink R (2016) Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation. J Neuroinflammation 13(1):264","journal-title":"J Neuroinflammation"},{"issue":"3","key":"3788_CR3","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1124\/jpet.118.253955","volume":"368","author":"A Kumar","year":"2019","unstructured":"Kumar A, Henry RJ, Stoica BA, Loane DJ, Abulwerdi G, Bhat SA, Faden AI (2019) Neutral sphingomyelinase inhibition alleviates LPS-induced microglia activation and neuroinflammation after experimental traumatic brain injury. J Pharmacol Exp Ther 368(3):338\u2013352","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"3788_CR4","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12974-017-0819-4","volume":"14","author":"A Kumar","year":"2017","unstructured":"Kumar A, Stoica BA, Loane DJ, Yang M, Abulwerdi G, Khan N, Kumar A, Thom SR, Faden AI (2017) Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury. J Neuroinflammation 14(1):47","journal-title":"J Neuroinflammation"},{"issue":"4","key":"3788_CR5","doi-asserted-by":"publisher","first-page":"667","DOI":"10.2165\/00003495-199856040-00015","volume":"56","author":"W McNeely","year":"1998","unstructured":"McNeely W, Goa KL (1998) 5-Methoxypsoralen. A review of its effects in psoriasis and vitiligo. Drugs 56(4):667\u2013690","journal-title":"Drugs"},{"issue":"10","key":"3788_CR6","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.3390\/molecules21101322","volume":"21","author":"G Kirsch","year":"2016","unstructured":"Kirsch G, Abdelwahab AB, Chaimbault P (2016) Natural and synthetic coumarins with effects on inflammation. Molecules 21(10):1322","journal-title":"Molecules"},{"issue":"4","key":"3788_CR7","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.3390\/ijms22041779","volume":"22","author":"\u0141 Kurach","year":"2021","unstructured":"Kurach \u0141, Kulczycka-Mamona S, Kowalczyk J, Skalicka-Wo\u017aniak K, Boguszewska-Czubara A, El Sayed N, Osmani M, Iwaniak K, Budzy\u0144ska B (2021) Mechanisms of the procognitive effects of xanthotoxin and umbelliferone on LPS-induced amnesia in mice. Int J Mol Sci 22(4):1779. https:\/\/doi.org\/10.3390\/ijms22041779","journal-title":"Int J Mol Sci"},{"key":"3788_CR8","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3389\/fcimb.2018.00178","volume":"8","author":"X Li","year":"2018","unstructured":"Li X, Yu C, Hu Y, Xia X, Liao Y, Zhang J, Chen H, Lu W, Zhou W, Song Z (2018) New Application of psoralen and angelicin on periodontitis with anti-bacterial, anti-inflammatory, and osteogenesis effects. Front Cell Infect Microbiol 8:178","journal-title":"Front Cell Infect Microbiol"},{"issue":"2","key":"3788_CR9","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1254\/fpj.154.56","volume":"154","author":"M Mukohda","year":"2019","unstructured":"Mukohda M (2019) Role of PPAR\u03b3, a transcription factor in cardiovascular disease. Nihon Yakurigaku Zasshi 154(2):56\u201360","journal-title":"Nihon Yakurigaku Zasshi"},{"issue":"3","key":"3788_CR10","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1002\/wsbm.1331","volume":"8","author":"S Mitchell","year":"2016","unstructured":"Mitchell S, Vargas J, Hoffmann A (2016) Signaling via the NF\u03baB system. Wiley Interdiscip Rev Syst Biol Med 8(3):227\u2013241","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"issue":"15","key":"3788_CR11","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.2174\/1389450119666180131105158","volume":"19","author":"S Kaur","year":"2018","unstructured":"Kaur S, Nag A, Singh AK, Sharma K (2018) PPAR\u03b3-targeting potential for radioprotection. Curr Drug Targets 19(15):1818\u20131830","journal-title":"Curr Drug Targets"},{"issue":"3","key":"3788_CR12","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1111\/jcmm.14105","volume":"23","author":"J Chen","year":"2019","unstructured":"Chen J, Xuan Y, Chen Y, Wu T, Chen L, Guan H, Yang S, He J, Shi D, Wang Y (2019) Netrin-1 alleviates subarachnoid haemorrhage-induced brain injury via the PPAR\u03b3\/NF-KB signalling pathway. J Cell Mol Med 23(3):2256\u20132262","journal-title":"J Cell Mol Med"},{"issue":"10","key":"3788_CR13","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1038\/aps.2017.208","volume":"39","author":"MT Song","year":"2018","unstructured":"Song MT, Ruan J, Zhang RY, Deng J, Ma ZQ, Ma SP (2018) Astragaloside IV ameliorates neuroinflammation-induced depressive-like behaviors in mice via the PPAR\u03b3\/NF-\u03baB\/NLRP3 inflammasome axis. Acta Pharmacol Sin 39(10):1559\u20131570","journal-title":"Acta Pharmacol Sin"},{"issue":"2","key":"3788_CR14","doi-asserted-by":"publisher","first-page":"83","DOI":"10.14573\/altex.2009.2.83","volume":"26","author":"A Henn","year":"2009","unstructured":"Henn A, Lund S, Hedtj\u00e4rn M, Schrattenholz A, P\u00f6rzgen P, Leist M (2009) The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation. Altex 26(2):83\u201394. doi: https:\/\/doi.org\/10.14573\/altex.2009.2.83","journal-title":"Altex"},{"issue":"5","key":"3788_CR15","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.3390\/cells9051231","volume":"9","author":"K Rusinek","year":"2020","unstructured":"Rusinek K, So\u0142ek P, Tab\u0119cka-\u0141onczy\u0144ska A, Koziorowski M, Mytych J (2020) Focus on the role of klotho protein in neuro-immune interactions in HT-22 cells upon LPS stimulation. Cells 9(5):1231. https:\/\/doi.org\/10.3390\/cells9051231","journal-title":"Cells"},{"issue":"1","key":"3788_CR16","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s12974-019-1561-x","volume":"26","author":"KY Ryu","year":"2019","unstructured":"Ryu KY, Lee HJ, Woo H, Kang RJ, Han KM, Park H, Lee SM, Lee JY, Jeong YJ, Nam HW, Nam Y, Hoe HS (2019) Dasatinib regulates LPS-induced microglial and astrocytic neuroinflammatory responses by inhibiting AKT\/STAT3 signaling. J Neuroinflammation 26(1):190. https:\/\/doi.org\/10.1186\/s12974-019-1561-x","journal-title":"J Neuroinflammation"},{"issue":"17","key":"3788_CR17","doi-asserted-by":"publisher","first-page":"6291","DOI":"10.3390\/ijms21176291","volume":"21","author":"ZH Liu","year":"2020","unstructured":"Liu ZH, Chen NY, Tu PH, Wu CT, Chiu SC, Huang YC, Lim SN, Yip PK (2020) DHA attenuates cerebral edema following traumatic brain injury via the reduction in blood-brain barrier permeability. Int J Mol Sci 21(17):6291","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3788_CR18","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.neulet.2008.02.046","volume":"436","author":"ON Kokiko-Cochran","year":"2008","unstructured":"Kokiko-Cochran ON, Michaels MP, Hamm RJ (2008) Delayed glucose treatment improves cognitive function following fluid-percussion injury. Neurosci Lett 436(1):27\u201330","journal-title":"Neurosci Lett"},{"key":"3788_CR19","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/1742-2094-8-147","volume":"8","author":"EB Yan","year":"2011","unstructured":"Yan EB, Hellewell SC, Bellander BM, Agyapomaa DA, Morganti-Kossmann MC (2011) Post-traumatic hypoxia exacerbates neurological deficit, neuroinflammation and cerebral metabolism in rats with diffuse traumatic brain injury. J Neuroinflammation 8:147","journal-title":"J Neuroinflammation"},{"key":"3788_CR20","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1515\/tnsci-2018-0026","volume":"9","author":"N Yu","year":"2018","unstructured":"Yu N, Hu S, Hao Z (2018) Benificial effect of stachydrine on the traumatic brain injury induced neurodegeneration by attenuating the expressions of Akt\/mTOR\/PI3K and TLR4\/NF\u03ba-B pathway. Transl Neurosci 9:175\u2013182","journal-title":"Transl Neurosci"},{"issue":"5","key":"3788_CR21","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1177\/1557988318772736","volume":"12","author":"Y Yuan","year":"2018","unstructured":"Yuan Y, Yang J, Zhu W, Liu T, He J, Zhou Q, Zhou X, Zhang X (2018) Qianlongtong inhibits proliferation and induces apoptosis of hyperplastic prostate cells. Am J Mens Health 12(5):1548\u20131553","journal-title":"Am J Mens Health"},{"issue":"1","key":"3788_CR22","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/cns.12991","volume":"25","author":"L Wang","year":"2019","unstructured":"Wang L, Song LF, Chen XY, Ma YL, Suo JF, Shi JH, Chen GH (2019) MiR-181b inhibits P38\/JNK signaling pathway to attenuate autophagy and apoptosis in juvenile rats with kainic acid-induced epilepsy via targeting TLR4. CNS Neurosci Ther 25(1):112\u2013122","journal-title":"CNS Neurosci Ther"},{"issue":"Pt B","key":"3788_CR23","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.neuropharm.2018.08.004","volume":"145","author":"RM Jha","year":"2019","unstructured":"Jha RM, Kochanek PM, Simard JM (2019) Pathophysiology and treatment of cerebral edema in traumatic brain injury. Neuropharmacology 145(Pt B):230\u2013246","journal-title":"Neuropharmacology"},{"issue":"4","key":"3788_CR24","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s11064-018-02714-z","volume":"44","author":"Y Yang","year":"2019","unstructured":"Yang Y, Ye Y, Kong C, Su X, Zhang X, Bai W, He X (2019) MiR-124 enriched exosomes promoted the M2 polarization of microglia and enhanced hippocampus neurogenesis after traumatic brain injury by inhibiting TLR4 pathway. Neurochem Res 44(4):811\u2013828","journal-title":"Neurochem Res"},{"issue":"61","key":"3788_CR25","doi-asserted-by":"publisher","first-page":"103236","DOI":"10.18632\/oncotarget.21139","volume":"8","author":"TH Hung","year":"2017","unstructured":"Hung TH, Shyue SK, Wu CH, Chen CC, Lin CC, Chang CF, Chen SF (2017) Deletion or inhibition of soluble epoxide hydrolase protects against brain damage and reduces microglia-mediated neuroinflammation in traumatic brain injury. Oncotarget 8(61):103236\u2013103260","journal-title":"Oncotarget"},{"issue":"10","key":"3788_CR26","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.1016\/j.immuni.2021.09.014","volume":"54","author":"K Borst","year":"2021","unstructured":"Borst K, Dumas AA, Prinz M (2021) Microglia immune and non-immune functions. Immunity 54(10):2194\u20132208. https:\/\/doi.org\/10.1016\/j.immuni.2021.09.014","journal-title":"Immunity"},{"issue":"3","key":"3788_CR27","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1007\/s12035-013-8620-6","volume":"49","author":"R Fu","year":"2014","unstructured":"Fu R, Shen Q, Xu P, Luo JJ, Tang Y (2014) Phagocytosis of microglia in the central nervous system diseases. Mol Neurobiol 49(3):1422\u20131434. https:\/\/doi.org\/10.1007\/s12035-013-8620-6","journal-title":"Mol Neurobiol"},{"issue":"6","key":"3788_CR28","first-page":"2353","volume":"12","author":"J An","year":"2020","unstructured":"An J, Chen B, Kang X, Zhang R, Guo Y, Zhao J, Yang H (2020) Neuroprotective effects of natural compounds on LPS-induced inflammatory responses in microglia. Am J Transl Res 12(6):2353\u20132378","journal-title":"Am J Transl Res"},{"issue":"11","key":"3788_CR29","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1016\/s0300-9084(00)88886-0","volume":"80","author":"G Levi","year":"1998","unstructured":"Levi G, Minghetti L, Aloisi F (1998) Regulation of prostanoid synthesis in microglial cells and effects of prostaglandin E2 on microglial functions. Biochimie 80(11):899\u2013904. https:\/\/doi.org\/10.1016\/s0300-9084(00)88886-0","journal-title":"Biochimie"},{"key":"3788_CR30","doi-asserted-by":"publisher","first-page":"5405104","DOI":"10.1155\/2017\/5405104.","volume":"2017","author":"H Xu","year":"2017","unstructured":"Xu H, Wang Z, Li J, Wu H, Peng Y, Fan L, Chen J, Gu C, Yan F, Wang L, Chen G (2017) The polarization states of microglia in TBI: a new paradigm for pharmacological intervention. Neural Plast 2017:5405104. https:\/\/doi.org\/10.1155\/2017\/5405104.","journal-title":"Neural Plast"},{"key":"3788_CR31","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.brainres.2011.11.027","volume":"1433","author":"Y He","year":"2012","unstructured":"He Y, Qu S, Wang J, He X, Lin W, Zhen H, Zhang X (2012) Neuroprotective effects of osthole pretreatment against traumatic brain injury in rats. Brain Res 1433:127\u2013136","journal-title":"Brain Res"},{"issue":"2","key":"3788_CR32","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1080\/08923973.2019.1608560","volume":"41","author":"L Kong","year":"2019","unstructured":"Kong L, Yao Y, Xia Y, Liang X, Ni Y, Yang J (2019) Osthole alleviates inflammation by down-regulating NF-\u03baB signaling pathway in traumatic brain injury. Immunopharmacol Immunotoxicol 41(2):349\u2013360","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"12","key":"3788_CR33","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1016\/j.intimp.2009.08.013","volume":"9","author":"E Nicolis","year":"2009","unstructured":"Nicolis E, Lampronti I, Dechecchi MC, Borgatti M, Tamanini A, Bezzerri V, Bianchi N, Mazzon M, Mancini I, Giri MG, Rizzotti P, Gambari R, Cabrini G (2009) Modulation of expression of IL-8 gene in bronchial epithelial cells by 5-methoxypsoralen. Int Immunopharmacol 9(12):1411\u20131422","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"3788_CR34","doi-asserted-by":"publisher","first-page":"308","DOI":"10.3109\/08923973.2015.1038751","volume":"37","author":"IJ Yang","year":"2015","unstructured":"Yang IJ, Lee DU, Shin HM (2015) Anti-inflammatory and antioxidant effects of coumarins isolated from Foeniculum vulgare in lipopolysaccharide-stimulated macrophages and 12-O-tetradecanoylphorbol-13-acetate-stimulated mice. Immunopharmacol Immunotoxicol 37(3):308\u2013317","journal-title":"Immunopharmacol Immunotoxicol"},{"issue":"10","key":"3788_CR35","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1111\/1348-0421.12730","volume":"63","author":"J Li","year":"2019","unstructured":"Li J, Yin P, Gong P, Lv A, Zhang Z, Liu F (2019) 8-Methoxypsoralen protects bovine mammary epithelial cells against lipopolysaccharide-induced inflammatory injury via suppressing JAK\/STAT and NF-\u03baB pathway. Microbiol Immunol 63(10):427\u2013437","journal-title":"Microbiol Immunol"},{"key":"3788_CR36","doi-asserted-by":"publisher","first-page":"113190","DOI":"10.1016\/j.physbeh.2020.113190","volume":"228","author":"L Zhao","year":"2021","unstructured":"Zhao L, Zhang L, Zhu W, Chen H, Ding Y, Cui G (2021) Inhibition of microRNA-203 protects against traumatic brain injury induced neural damages via suppressing neuronal apoptosis and dementia-related molecues. Physiol Behav 228:113190. https:\/\/doi.org\/10.1016\/j.physbeh.2020.113190","journal-title":"Physiol Behav"},{"issue":"4","key":"3788_CR37","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1007\/s12017-020-08599-y","volume":"22","author":"L Zhang","year":"2020","unstructured":"Zhang L, Zhao L, Zhu W, Ding Y, Chen H, Chi N (2020) miR-146a mimics ameliorates traumatic brain injury involving JNK and NF-\u03baB signaling pathway. Neuromolecul Med 22(4):484\u2013492. https:\/\/doi.org\/10.1007\/s12017-020-08599-y","journal-title":"Neuromolecul Med"},{"issue":"8","key":"3788_CR38","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1007\/s11064-019-02825-1","volume":"44","author":"D Li","year":"2019","unstructured":"Li D, Huang S, Yin Z, Zhu J, Ge X, Han Z, Tan J, Zhang S, Zhao J, Chen F, Wang H, Lei P (2019) Increases in miR-124-3p in microglial exosomes confer neuroprotective effects by targeting fip200-mediated neuronal autophagy following traumatic brain injury. Neurochem Res 44(8):1903\u20131923. https:\/\/doi.org\/10.1007\/s11064-019-02825-1","journal-title":"Neurochem Res"},{"issue":"11","key":"3788_CR39","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1038\/jcbfm.2012.126","volume":"32","author":"WM Pardridge","year":"2012","unstructured":"Pardridge WM (2012) Drug transport across the blood-brain barrier. J Cereb Blood Flow Metab 32(11):1959\u20131972. https:\/\/doi.org\/10.1038\/jcbfm.2012.126","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"3788_CR40","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.jconrel.2011.08.017","volume":"161","author":"S Wohlfart","year":"2012","unstructured":"Wohlfart S, Gelperina S, Kreuter J (2012) Transport of drugs across the blood-brain barrier by nanoparticles. J Control Release 161(2):264\u2013273. https:\/\/doi.org\/10.1016\/j.jconrel.2011.08.017","journal-title":"J Control Release"},{"issue":"2","key":"3788_CR41","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1039\/c5bm00383k","volume":"4","author":"TT Zhang","year":"2016","unstructured":"Zhang TT, Li W, Meng G, Wang P, W Liao (2016) Strategies for transporting nanoparticles across the blood-brain barrier. Biomater Sci 4(2):219\u2013229. https:\/\/doi.org\/10.1039\/c5bm00383k","journal-title":"Biomater Sci"},{"issue":"13","key":"3788_CR42","doi-asserted-by":"publisher","first-page":"4278","DOI":"10.26355\/eurrev_201807_15424.","volume":"22","author":"C Liu","year":"2018","unstructured":"Liu C, Zhong L, Tian XL, Han YC (2018) Protective effects of 8-MOP on blood-brain barrier via the Nrf-2\/HO-1 pathway in mice model of cerebral infarction. Eur Rev Med Pharmacol Sci 22(13):4278\u20134287. https:\/\/doi.org\/10.26355\/eurrev_201807_15424.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"1","key":"3788_CR43","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s10571-017-0554-5","volume":"38","author":"S Villapol","year":"2018","unstructured":"Villapol S (2018) Roles of Peroxisome Proliferator-Activated Receptor Gamma on Brain and Peripheral Inflammation. Cell Mol Neurobiol 38(1):121\u2013132","journal-title":"Cell Mol Neurobiol"},{"issue":"6","key":"3788_CR44","doi-asserted-by":"publisher","first-page":"3395","DOI":"10.1128\/MCB.18.6.3395","volume":"18","author":"CH Shen","year":"1998","unstructured":"Shen CH, Stavnezer J (1998) Interaction of stat6 and NF-kappaB: direct association and synergistic activation of interleukin-4-induced transcription. Mol Cell Biol 18(6):3395\u20133404","journal-title":"Mol Cell Biol"},{"issue":"2","key":"3788_CR45","doi-asserted-by":"publisher","first-page":"242","DOI":"10.4161\/cc.4.2.1471","volume":"4","author":"LH Wang","year":"2005","unstructured":"Wang LH, Yang XY, Zhang X, Farrar WL (2005) Nuclear receptors as negative modulators of STAT3 in multiple myeloma. Cell Cycle 4(2):242\u2013245","journal-title":"Cell Cycle"},{"issue":"4","key":"3788_CR46","first-page":"283","volume":"3","author":"L Qi","year":"2010","unstructured":"Qi L, Jacob A, Wang P, Wu R (2010) Peroxisome proliferator activated receptor-\u03b3 and traumatic brain injury. Int J Clin Exp Med 3(4):283\u2013292","journal-title":"Int J Clin Exp Med"},{"issue":"4","key":"3788_CR47","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.ccr.2009.02.015","volume":"15","author":"H Lee","year":"2009","unstructured":"Lee H, Herrmann A, Deng JH, Kujawski M, Niu G, Li Z, Forman S, Jove R, Pardoll DM, Yu H (2009) Persistently activated Stat3 maintains constitutive NF-kappaBactivity in tumors. Cancer Cell 15(4):283\u201393. https:\/\/doi.org\/10.1016\/j.ccr.2009.02.015","journal-title":"Cancer Cell"},{"key":"3788_CR48","doi-asserted-by":"publisher","first-page":"106083","DOI":"10.1016\/j.intimp.2019.106083","volume":"79","author":"Q Jiang","year":"2020","unstructured":"Jiang Q, Chen J, Long X, Yao X, Zou X, Yang Y, Huang G, Zhang H (2020) Phillyrin protects mice from traumatic brain injury by inhibiting the inflammation of microglia via PPAR\u03b3 signaling pathway. Int Immunopharmacol 79:106083","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"3788_CR49","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.gendis.2019.05.002","volume":"7","author":"Y Deng","year":"2019","unstructured":"Deng Y, Jiang X, Deng X, Chen H, Xu J, Zhang Z, Liu G, Yong Z, Yuan C, Sun X, Wang C (2019) Pioglitazone ameliorates neuronal damage after traumatic brain injury via the PPAR\u03b3\/NF-\u03baB\/IL-6 signaling pathway. Genes Dis 7(2):253\u2013265","journal-title":"Genes Dis"},{"key":"3788_CR50","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jneuroim.2018.04.009","volume":"320","author":"BSF Mello","year":"2018","unstructured":"Mello BSF, Chaves Filho AJM, Cust\u00f3dio CS, Cordeiro RC, Miyajima F, de Sousa FCF, Vasconcelos SMM, de Lucena DF, Macedo D (2018) Sex influences in behavior and brain inflammatory and oxidative alterations in mice submitted to lipopolysaccharide-induced inflammatory model of depression. J Neuroimmunol 320:133\u2013142. https:\/\/doi.org\/10.1016\/j.jneuroim.2018.04.009","journal-title":"J Neuroimmunol"},{"issue":"8","key":"3788_CR51","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1089\/neu.2011.2134","volume":"38","author":"Chinese Head Trauma Study Collaborators","year":"2021","unstructured":"Chinese Head Trauma Study Collaborators (2021) Chinese head trauma data bank\u202f: effect of gender on the outcome of patients with acute traumatic brain injury. J Neurotrauma 38(8):1164\u20131167. https:\/\/doi.org\/10.1089\/neu.2011.2134","journal-title":"J Neurotrauma"},{"issue":"11","key":"3788_CR52","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.3109\/02699052.2012.667592.","volume":"26","author":"C Renner","year":"2012","unstructured":"Renner C, Hummelsheim H, Kopczak A, Steube D, Schneider HJ, Schneider M, Kreitschmann-Andermahr I, Jordan M, Uhl E, Stalla GK (2012) The influence of gender on the injury severity, course and outcome of traumatic brain injury. Brain Inj 26(11):1360\u20131371. https:\/\/doi.org\/10.3109\/02699052.2012.667592.","journal-title":"Brain Inj"},{"issue":"12","key":"3788_CR53","doi-asserted-by":"publisher","first-page":"e00832","DOI":"10.1002\/brb3.832","volume":"7","author":"D DeMaster","year":"2017","unstructured":"DeMaster D, Johnson C, Juranek J, Ewing-Cobbs L (2017) Memory and the hippocampal formation following pediatric traumatic brain injury. Brain Behav 7(12):e00832. https:\/\/doi.org\/10.1002\/brb3.832","journal-title":"Brain Behav"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-022-03788-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-022-03788-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-022-03788-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T11:36:22Z","timestamp":1675251382000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-022-03788-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,1]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["3788"],"URL":"https:\/\/doi.org\/10.1007\/s11064-022-03788-6","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,1]]},"assertion":[{"value":"13 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 October 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Our study was approved by the ethic committee of Liaocheng People\u2019s Hospital (Approve No: LC-H2019039).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}