{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:37:15Z","timestamp":1773884235790,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","license":[{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T00:00:00Z","timestamp":1675036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Hainan Provincial Natural Science Foundation Youth Project","award":["821QN422"],"award-info":[{"award-number":["821QN422"]}]},{"name":"Hainan Provincial Clinical Medical Center Construction Project"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"DOI":"10.1007\/s11064-023-03866-3","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T21:19:26Z","timestamp":1675113566000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Exosomal ZEB1 Derived from Neural Stem Cells Reduces Inflammation Injury in OGD\/R-Treated Microglia via the GPR30-TLR4-NF-\u03baB Axis"],"prefix":"10.1007","author":[{"given":"Jun","family":"Peng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengtao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongjun","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiqi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,30]]},"reference":[{"issue":"9913","key":"3866_CR1","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/s0140-6736(13)61953-4","volume":"383","author":"VL Feigin","year":"2014","unstructured":"Feigin VL, Forouzanfar MH, Krishnamurthi R et al (2014) Global and regional burden of stroke during 1990\u20132010: findings from the Global Burden of Disease Study 2010. Lancet 383(9913):245\u2013255. https:\/\/doi.org\/10.1016\/s0140-6736(13)61953-4","journal-title":"Lancet"},{"issue":"1","key":"3866_CR2","first-page":"15","volume":"23","author":"A Guzik","year":"2017","unstructured":"Guzik A, Bushnell C (2017) Stroke epidemiology and risk factor management. Continuum 23(1):15\u201339","journal-title":"Continuum"},{"issue":"5","key":"3866_CR3","doi-asserted-by":"publisher","first-page":"R398","DOI":"10.1152\/ajpregu.00270.2015","volume":"310","author":"RL Hoiland","year":"2016","unstructured":"Hoiland RL, Bain AR, Rieger MG et al (2016) Hypoxemia, oxygen content, and the regulation of cerebral blood flow. Am J Physiol Regul Integr Comp Physiol 310(5):R398-413. https:\/\/doi.org\/10.1152\/ajpregu.00270.2015","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"3866_CR4","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1186\/s12974-019-1516-2","volume":"16","author":"RL Jayaraj","year":"2019","unstructured":"Jayaraj RL, Azimullah S, Beiram R et al (2019) Neuroinflammation: friend and foe for ischemic stroke. J Neuroinflamm 16(1):142. https:\/\/doi.org\/10.1186\/s12974-019-1516-2","journal-title":"J Neuroinflamm"},{"key":"3866_CR5","doi-asserted-by":"publisher","first-page":"107695","DOI":"10.1016\/j.pharmthera.2020.107695","volume":"216","author":"T Tao","year":"2020","unstructured":"Tao T, Liu M, Chen M et al (2020) Natural medicine in neuroprotection for ischemic stroke: challenges and prospective. Pharmacol Ther 216:107695. https:\/\/doi.org\/10.1016\/j.pharmthera.2020.107695","journal-title":"Pharmacol Ther"},{"issue":"1","key":"3866_CR6","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1002\/glia.23697","volume":"68","author":"XS Wang","year":"2020","unstructured":"Wang XS, Yue J, Hu LN et al (2020) Activation of G protein-coupled receptor 30 protects neurons by regulating autophagy in astrocytes. Glia 68(1):27\u201343. https:\/\/doi.org\/10.1002\/glia.23697","journal-title":"Glia"},{"key":"3866_CR7","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977","author":"R Kalluri","year":"2020","unstructured":"Kalluri R, LeBleu VS (2020) The biology, function, and biomedical applications of exosomes. Science. https:\/\/doi.org\/10.1126\/science.aau6977","journal-title":"Science"},{"issue":"1","key":"3866_CR8","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/s41392-020-00261-0","volume":"5","author":"J Dai","year":"2020","unstructured":"Dai J, Su Y, Zhong S et al (2020) Exosomes: key players in cancer and potential therapeutic strategy. Signal Transduct Target Ther 5(1):145. https:\/\/doi.org\/10.1038\/s41392-020-00261-0","journal-title":"Signal Transduct Target Ther"},{"key":"3866_CR9","doi-asserted-by":"publisher","first-page":"90","DOI":"10.3389\/fimmu.2018.00090","volume":"9","author":"W Zhang","year":"2018","unstructured":"Zhang W, Jiang X, Bao J et al (2018) Exosomes in pathogen infections: a bridge to deliver molecules and link functions. Front Immunol 9:90. https:\/\/doi.org\/10.3389\/fimmu.2018.00090","journal-title":"Front Immunol"},{"key":"3866_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/cells8020166","author":"G Bellin","year":"2019","unstructured":"Bellin G, Gardin C, Ferroni L et al (2019) Exosome in cardiovascular diseases: a complex world full of hope. Cells. https:\/\/doi.org\/10.3390\/cells8020166","journal-title":"Cells"},{"key":"3866_CR11","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3389\/fnmol.2019.00240","volume":"12","author":"W Liu","year":"2019","unstructured":"Liu W, Bai X, Zhang A et al (2019) Role of exosomes in central nervous system diseases. Front Mol Neurosci 12:240. https:\/\/doi.org\/10.3389\/fnmol.2019.00240","journal-title":"Front Mol Neurosci"},{"issue":"5","key":"3866_CR12","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/s41419-019-1571-8","volume":"10","author":"Y Rong","year":"2019","unstructured":"Rong Y, Liu W, Wang J et al (2019) Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy. Cell Death Dis 10(5):340. https:\/\/doi.org\/10.1038\/s41419-019-1571-8","journal-title":"Cell Death Dis"},{"issue":"1","key":"3866_CR13","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1186\/s12964-019-0418-3","volume":"17","author":"Y Ma","year":"2019","unstructured":"Ma Y, Li C, Huang Y et al (2019) Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a. Cell Commun Signal 17(1):96. https:\/\/doi.org\/10.1186\/s12964-019-0418-3","journal-title":"Cell Commun Signal"},{"key":"3866_CR14","doi-asserted-by":"publisher","first-page":"601600","DOI":"10.3389\/fcell.2021.601600","volume":"9","author":"P Yuan","year":"2021","unstructured":"Yuan P, Ding L, Chen H et al (2021) Neural stem cell-derived exosomes regulate neural stem cell differentiation through miR-9-Hes1 axis. Front Cell Dev Biol 9:601600. https:\/\/doi.org\/10.3389\/fcell.2021.601600","journal-title":"Front Cell Dev Biol"},{"key":"3866_CR15","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1016\/j.jare.2020.05.017","volume":"24","author":"G Zhang","year":"2020","unstructured":"Zhang G, Zhu Z, Wang H et al (2020) Exosomes derived from human neural stem cells stimulated by interferon gamma improve therapeutic ability in ischemic stroke model. J Adv Res 24:435\u2013445. https:\/\/doi.org\/10.1016\/j.jare.2020.05.017","journal-title":"J Adv Res"},{"issue":"5","key":"3866_CR16","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1161\/STROKEAHA.117.020353","volume":"49","author":"RL Webb","year":"2018","unstructured":"Webb RL, Kaiser EE, Jurgielewicz BJ et al (2018) Human neural stem cell extracellular vesicles improve recovery in a porcine model of ischemic stroke. Stroke 49(5):1248\u20131256. https:\/\/doi.org\/10.1161\/STROKEAHA.117.020353","journal-title":"Stroke"},{"issue":"10","key":"3866_CR17","doi-asserted-by":"publisher","first-page":"2453","DOI":"10.1093\/emboj\/cdg226","volume":"22","author":"AA Postigo","year":"2003","unstructured":"Postigo AA, Depp JL, Taylor JJ et al (2003) Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J 22(10):2453\u20132462","journal-title":"EMBO J"},{"key":"3866_CR18","doi-asserted-by":"publisher","first-page":"10498","DOI":"10.1038\/ncomms10498","volume":"7","author":"W Lehmann","year":"2016","unstructured":"Lehmann W, Mossmann D, Kleemann J et al (2016) ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types. Nat Commun 7:10498. https:\/\/doi.org\/10.1038\/ncomms10498","journal-title":"Nat Commun"},{"issue":"1","key":"3866_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12967-020-02240-z","volume":"18","author":"HT Wu","year":"2020","unstructured":"Wu HT, Zhong HT, Li GW et al (2020) Oncogenic functions of the EMT-related transcription factor ZEB1 in breast cancer. J Transl Med 18(1):51. https:\/\/doi.org\/10.1186\/s12967-020-02240-z","journal-title":"J Transl Med"},{"key":"3866_CR20","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3389\/fmolb.2020.00036","volume":"7","author":"S Drapela","year":"2020","unstructured":"Drapela S, Bouchal J, Jolly MK et al (2020) ZEB1: a critical regulator of cell plasticity, DNA damage response, and therapy resistance. Front Mol Biosci 7:36. https:\/\/doi.org\/10.3389\/fmolb.2020.00036","journal-title":"Front Mol Biosci"},{"issue":"7","key":"3866_CR21","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1128\/MCB.01259-12","volume":"33","author":"L Siles","year":"2013","unstructured":"Siles L, Sanchez-Tillo E, Lim JW et al (2013) ZEB1 imposes a temporary stage-dependent inhibition of muscle gene expression and differentiation via CtBP-mediated transcriptional repression. Mol Cell Biol 33(7):1368\u20131382. https:\/\/doi.org\/10.1128\/MCB.01259-12","journal-title":"Mol Cell Biol"},{"issue":"6","key":"3866_CR22","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1177\/0022034520982249","volume":"100","author":"Y Xiao","year":"2021","unstructured":"Xiao Y, Lin YX, Cui Y et al (2021) Zeb1 promotes odontoblast differentiation in a stage-dependent manner. J Dent Res 100(6):648\u2013657. https:\/\/doi.org\/10.1177\/0022034520982249","journal-title":"J Dent Res"},{"issue":"9","key":"3866_CR23","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1002\/stem.1448","volume":"31","author":"Z Luo","year":"2013","unstructured":"Luo Z, Wen G, Wang G et al (2013) MicroRNA-200C and -150 play an important role in endothelial cell differentiation and vasculogenesis by targeting transcription repressor ZEB1. Stem Cells 31(9):1749\u20131762. https:\/\/doi.org\/10.1002\/stem.1448","journal-title":"Stem Cells"},{"issue":"8","key":"3866_CR24","doi-asserted-by":"publisher","first-page":"2335","DOI":"10.1016\/j.celrep.2019.04.081","volume":"27","author":"H Wang","year":"2019","unstructured":"Wang H, Xiao Z, Zheng J et al (2019) ZEB1 represses neural differentiation and cooperates with CTBP2 to dynamically regulate cell migration during neocortex development. Cell Rep 27(8):2335-2353.e6. https:\/\/doi.org\/10.1016\/j.celrep.2019.04.081","journal-title":"Cell Rep"},{"issue":"11","key":"3866_CR25","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1038\/s41418-019-0314-9","volume":"26","author":"J Liu","year":"2019","unstructured":"Liu J, Liu Y, Shao J et al (2019) Zeb1 is important for proper cleavage plane orientation of dividing progenitors and neuronal migration in the mouse neocortex. Cell Death Differ 26(11):2479\u20132492. https:\/\/doi.org\/10.1038\/s41418-019-0314-9","journal-title":"Cell Death Differ"},{"issue":"8","key":"3866_CR26","doi-asserted-by":"publisher","first-page":"109588","DOI":"10.1016\/j.celrep.2021.109588","volume":"36","author":"B Gupta","year":"2021","unstructured":"Gupta B, Errington AC, Jimenez-Pascual A et al (2021) The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus. Cell Rep 36(8):109588. https:\/\/doi.org\/10.1016\/j.celrep.2021.109588","journal-title":"Cell Rep"},{"issue":"31","key":"3866_CR27","doi-asserted-by":"publisher","first-page":"12959","DOI":"10.1074\/jbc.M116.771493","volume":"292","author":"L Yan","year":"2017","unstructured":"Yan L, Li Y, Shi Z et al (2017) The zinc finger E-box-binding homeobox 1 (Zeb1) promotes the conversion of mouse fibroblasts into functional neurons. J Biol Chem 292(31):12959\u201312970. https:\/\/doi.org\/10.1074\/jbc.M116.771493","journal-title":"J Biol Chem"},{"issue":"12","key":"3866_CR28","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1042\/CS20160114","volume":"130","author":"MA Zimmerman","year":"2016","unstructured":"Zimmerman MA, Budish RA, Kashyap S et al (2016) GPER-novel membrane oestrogen receptor. Clin Sci 130(12):1005\u20131016. https:\/\/doi.org\/10.1042\/CS20160114","journal-title":"Clin Sci"},{"issue":"1","key":"3866_CR29","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12974-018-1246-x","volume":"15","author":"Z Zhang","year":"2018","unstructured":"Zhang Z, Qin P, Deng Y et al (2018) The novel estrogenic receptor GPR30 alleviates ischemic injury by inhibiting TLR4-mediated microglial inflammation. J Neuroinflamm 15(1):206. https:\/\/doi.org\/10.1186\/s12974-018-1246-x","journal-title":"J Neuroinflamm"},{"key":"3866_CR30","doi-asserted-by":"publisher","first-page":"101938","DOI":"10.1016\/j.jchemneu.2021.101938","volume":"113","author":"D Nazarinia","year":"2021","unstructured":"Nazarinia D, Dolatshahi M, Faezi M et al (2021) TLR4 \/NF-kB and JAK2\/STAT3 signaling pathways: cellular signaling pathways targeted by cell-conditioned medium therapy in protection against ischemic stroke. J Chem Neuroanat 113:101938. https:\/\/doi.org\/10.1016\/j.jchemneu.2021.101938","journal-title":"J Chem Neuroanat"},{"issue":"8","key":"3866_CR31","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1016\/j.ymthe.2018.05.019","volume":"26","author":"G Fernandez","year":"2018","unstructured":"Fernandez G, Moraga A, Cuartero MI et al (2018) TLR4-binding DNA aptamers show a protective effect against acute stroke in animal models. Mol Ther 26(8):2047\u20132059. https:\/\/doi.org\/10.1016\/j.ymthe.2018.05.019","journal-title":"Mol Ther"},{"key":"3866_CR32","doi-asserted-by":"publisher","DOI":"10.3791\/56482","author":"MK Jung","year":"2018","unstructured":"Jung MK, Mun JY (2018) Sample preparation and imaging of exosomes by transmission electron microscopy. J Vis Exp. https:\/\/doi.org\/10.3791\/56482","journal-title":"J Vis Exp"},{"issue":"1","key":"3866_CR33","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41572-019-0118-8","volume":"5","author":"BCV Campbell","year":"2019","unstructured":"Campbell BCV, De Silva DA, Macleod MR et al (2019) Ischaemic stroke. Nat Rev Dis Primers 5(1):70. https:\/\/doi.org\/10.1038\/s41572-019-0118-8","journal-title":"Nat Rev Dis Primers"},{"issue":"13","key":"3866_CR34","doi-asserted-by":"publisher","first-page":"3574","DOI":"10.1016\/j.celrep.2018.03.011","volume":"22","author":"D Li","year":"2018","unstructured":"Li D, Lang W, Zhou C et al (2018) Upregulation of microglial ZEB1 ameliorates brain damage after acute ischemic stroke. Cell Rep 22(13):3574\u20133586. https:\/\/doi.org\/10.1016\/j.celrep.2018.03.011","journal-title":"Cell Rep"},{"issue":"1","key":"3866_CR35","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12943-019-0991-5","volume":"18","author":"L Mashouri","year":"2019","unstructured":"Mashouri L, Yousefi H, Aref AR et al (2019) Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance. Mol Cancer 18(1):75. https:\/\/doi.org\/10.1186\/s12943-019-0991-5","journal-title":"Mol Cancer"},{"issue":"1","key":"3866_CR36","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s13195-021-00791-x","volume":"13","author":"LA Apodaca","year":"2021","unstructured":"Apodaca LA, Baddour AAD, Garcia C Jr et al (2021) Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer\u2019s disease. Alzheimers Res Ther 13(1):57. https:\/\/doi.org\/10.1186\/s13195-021-00791-x","journal-title":"Alzheimers Res Ther"},{"issue":"4","key":"3866_CR37","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1097\/FJC.0000000000000974","volume":"77","author":"D Chen","year":"2021","unstructured":"Chen D, Wang K, Zheng Y et al (2021) Exosomes-mediated LncRNA ZEB1-AS1 facilitates cell injuries by miR-590-5p\/ETS1 axis through the TGF-beta\/smad pathway in oxidized low-density lipoprotein-induced human umbilical vein endothelial cells. J Cardiovasc Pharmacol 77(4):480\u2013490. https:\/\/doi.org\/10.1097\/FJC.0000000000000974","journal-title":"J Cardiovasc Pharmacol"},{"key":"3866_CR38","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129115","author":"A Almotiri","year":"2021","unstructured":"Almotiri A, Alzahrani H, Menendez-Gonzalez JB et al (2021) Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia. J Clin Investig. https:\/\/doi.org\/10.1172\/JCI129115","journal-title":"J Clin Investig"},{"issue":"12","key":"3866_CR39","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1136\/gutjnl-2018-317294","volume":"68","author":"O de Barrios","year":"2019","unstructured":"de Barrios O, Sanchez-Moral L, Cortes M et al (2019) ZEB1 promotes inflammation and progression towards inflammation-driven carcinoma through repression of the DNA repair glycosylase MPG in epithelial cells. Gut 68(12):2129\u20132141. https:\/\/doi.org\/10.1136\/gutjnl-2018-317294","journal-title":"Gut"},{"issue":"4","key":"3866_CR40","doi-asserted-by":"publisher","first-page":"104038","DOI":"10.1016\/j.isci.2022.104038","volume":"25","author":"W Liang","year":"2022","unstructured":"Liang W, Zhang Y, Zhou L et al (2022) Zeb1 regulation of wound-healing-induced inflammation in alkali-damaged corneas. iScience 25(4):104038. https:\/\/doi.org\/10.1016\/j.isci.2022.104038","journal-title":"iScience"},{"issue":"1\u20132","key":"3866_CR41","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.mce.2009.03.026","volume":"308","author":"ER Prossnitz","year":"2009","unstructured":"Prossnitz ER, Maggiolini M (2009) Mechanisms of estrogen signaling and gene expression via GPR30. Mol Cell Endocrinol 308(1\u20132):32\u201338. https:\/\/doi.org\/10.1016\/j.mce.2009.03.026","journal-title":"Mol Cell Endocrinol"},{"issue":"3","key":"3866_CR42","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1210\/me.2008-0299","volume":"23","author":"SD Noel","year":"2009","unstructured":"Noel SD, Keen KL, Baumann DI et al (2009) Involvement of G protein-coupled receptor 30 (GPR30) in rapid action of estrogen in primate LHRH neurons. Mol Endocrinol 23(3):349\u2013359. https:\/\/doi.org\/10.1210\/me.2008-0299","journal-title":"Mol Endocrinol"},{"key":"3866_CR43","doi-asserted-by":"publisher","first-page":"113008","DOI":"10.1016\/j.expneurol.2019.113008","volume":"320","author":"J Peng","year":"2019","unstructured":"Peng J, Zuo Y, Huang L et al (2019) Activation of GPR30 with G1 attenuates neuronal apoptosis via src\/EGFR\/stat3 signaling pathway after subarachnoid hemorrhage in male rats. Exp Neurol 320:113008. https:\/\/doi.org\/10.1016\/j.expneurol.2019.113008","journal-title":"Exp Neurol"},{"key":"3866_CR44","doi-asserted-by":"publisher","first-page":"579420","DOI":"10.3389\/fendo.2020.579420","volume":"11","author":"G Notas","year":"2020","unstructured":"Notas G, Kampa M, Castanas E (2020) G protein-coupled estrogen receptor in immune cells and its role in immune-related diseases. Front Endocrinol 11:579420. https:\/\/doi.org\/10.3389\/fendo.2020.579420","journal-title":"Front Endocrinol"},{"issue":"4","key":"3866_CR45","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/s12975-012-0211-8","volume":"3","author":"Y Kosaka","year":"2012","unstructured":"Kosaka Y, Quillinan N, Bond C et al (2012) GPER1\/GPR30 activation improves neuronal survival following global cerebral ischemia induced by cardiac arrest in mice. Transl Stroke Res 3(4):500\u2013507. https:\/\/doi.org\/10.1007\/s12975-012-0211-8","journal-title":"Transl Stroke Res"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-023-03866-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-023-03866-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-023-03866-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T14:50:34Z","timestamp":1683816634000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-023-03866-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,30]]},"references-count":45,"alternative-id":["3866"],"URL":"https:\/\/doi.org\/10.1007\/s11064-023-03866-3","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,30]]},"assertion":[{"value":"10 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 September 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"The animal study was reviewed and approved by Haikou People\u2019s Hospital.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The informed consent obtained from study participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}