{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:46:06Z","timestamp":1786981566977,"version":"build-2736575974"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T00:00:00Z","timestamp":1676419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"VIDCA, UACh."},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1191620"],"award-info":[{"award-number":["1191620"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1141067"],"award-info":[{"award-number":["1141067"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1007\/s11064-023-03889-w","type":"journal-article","created":{"date-parts":[[2023,2,17]],"date-time":"2023-02-17T02:15:05Z","timestamp":1676600105000},"page":"2093-2103","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Modulation of Synaptic Plasticity Genes Associated to DNA Damage in a Model of Huntington\u2019s Disease"],"prefix":"10.1007","volume":"48","author":[{"given":"Johana","family":"Spies","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Covarrubias-Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Carcamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yennyfer","family":"Arancibia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Paredes-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Otth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9359-2786","authenticated-orcid":false,"given":"Angara","family":"Zambrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,2,15]]},"reference":[{"key":"3889_CR1","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1097\/00005072-198511000-00003","volume":"44","author":"J-P Vonsattel","year":"1985","unstructured":"Vonsattel J-P, Myers RH, Stevens TJ et al (1985) Neuropathological classification of Huntington\u2019s disease. J Neuropathol Exp Neurol 44:559\u2013577. https:\/\/doi.org\/10.1097\/00005072-198511000-00003","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"3889_CR2","first-page":"21","volume":"31","author":"A Montoya","year":"2006","unstructured":"Montoya A, Price BH, Menear M, Lepage M (2006) Brain imaging and cognitive dysfunctions in Huntington\u2019s disease. J Psychiatr Neurosci 31(1):21\u201329","journal-title":"J Psychiatr Neurosci"},{"key":"3889_CR3","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"ME MacDonald","year":"1993","unstructured":"MacDonald ME, Ambrose CM, Duyao MP et al (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. Cell 72:971\u2013983. https:\/\/doi.org\/10.1016\/0092-8674(93)90585-E","journal-title":"Cell"},{"key":"3889_CR4","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1023\/B:NERE.0000014824.04728.dd","volume":"29","author":"SE Browne","year":"2004","unstructured":"Browne SE, Beal MF (2004) The energetics of Huntington\u2019s disease. Neurochem Res 29:531\u2013546. https:\/\/doi.org\/10.1023\/B:NERE.0000014824.04728.dd","journal-title":"Neurochem Res"},{"key":"3889_CR5","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1089\/ars.2006.8.2061","volume":"8","author":"SE Browne","year":"2006","unstructured":"Browne SE, Beal MF (2006) Oxidative damage in Huntington\u2019s disease pathogenesis. Antioxid Redox Signal 8:2061\u20132073. https:\/\/doi.org\/10.1089\/ars.2006.8.2061","journal-title":"Antioxid Redox Signal"},{"key":"3889_CR6","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1038\/nature05292","volume":"443","author":"MT Lin","year":"2006","unstructured":"Lin MT, Beal MF (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443:787\u2013795. https:\/\/doi.org\/10.1038\/nature05292","journal-title":"Nature"},{"key":"3889_CR7","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1007\/s12035-012-8274-9","volume":"45","author":"GS Jeon","year":"2012","unstructured":"Jeon GS, Kim KY, Hwang YJ et al (2012) Deregulation of BRCA1 leads to impaired spatiotemporal dynamics of \u03b3-H2AX and DNA damage responses in Huntington\u2019s disease. Mol Neurobiol 45:550\u2013563. https:\/\/doi.org\/10.1007\/s12035-012-8274-9","journal-title":"Mol Neurobiol"},{"key":"3889_CR8","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1016\/j.neuroscience.2008.11.024","volume":"158","author":"A Giralt","year":"2009","unstructured":"Giralt A, Rodrigo T, Mart\u00edn ED et al (2009) Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: involvement of phospholipaseC\u03b3 activity and glutamate receptor expression. Neuroscience 158:1234\u20131250. https:\/\/doi.org\/10.1016\/j.neuroscience.2008.11.024","journal-title":"Neuroscience"},{"key":"3889_CR9","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1093\/hmg\/ddr552","volume":"21","author":"A Giralt","year":"2012","unstructured":"Giralt A, Puigdell\u00edvol M, Carret\u00f3n O et al (2012) Long-term memory deficits in Huntington\u2019s disease are associated with reduced CBP histone acetylase activity. Hum Mol Genet 21:1203\u20131216. https:\/\/doi.org\/10.1093\/hmg\/ddr552","journal-title":"Hum Mol Genet"},{"key":"3889_CR10","doi-asserted-by":"publisher","first-page":"10428","DOI":"10.1523\/JNEUROSCI.19-23-10428.1999","volume":"19","author":"LA Lione","year":"1999","unstructured":"Lione LA, Carter RJ, Hunt MJ et al (1999) Selective discrimination learning impairments in mice expressing the human Huntington\u2019s disease mutation. J Neurosci 19:10428\u201310437. https:\/\/doi.org\/10.1523\/JNEUROSCI.19-23-10428.1999","journal-title":"J Neurosci"},{"key":"3889_CR11","doi-asserted-by":"publisher","first-page":"4906","DOI":"10.1073\/pnas.0811228106","volume":"106","author":"DA Simmons","year":"2009","unstructured":"Simmons DA, Rex CS, Palmer L et al (2009) Up-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington\u2019s disease knockin mice. Proc Natl Acad Sci 106:4906\u20134911. https:\/\/doi.org\/10.1073\/pnas.0811228106","journal-title":"Proc Natl Acad Sci"},{"key":"3889_CR12","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1517\/14728222.7.1.101","volume":"7","author":"A Barco","year":"2003","unstructured":"Barco A, Pittenger C, Kandel ER (2003) CREB, memory enhancement and the treatment of memory disorders: promises, pitfalls and prospects. Expert Opin Ther Targets 7:101\u2013114. https:\/\/doi.org\/10.1517\/14728222.7.1.101","journal-title":"Expert Opin Ther Targets"},{"key":"3889_CR13","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1126\/science.1067020","volume":"294","author":"ER Kandel","year":"2001","unstructured":"Kandel ER (2001) The molecular biology of memory storage: a dialogue between genes and synapses. Science 294:1030\u20131038. https:\/\/doi.org\/10.1126\/science.1067020","journal-title":"Science"},{"key":"3889_CR14","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1146\/annurev.neuro.21.1.127","volume":"21","author":"AJ Silva","year":"1998","unstructured":"Silva AJ, Kogan JH, Frankland PW, Kida S (1998) CREB and memory. Annu Rev Neurosci 21:127\u2013148. https:\/\/doi.org\/10.1146\/annurev.neuro.21.1.127","journal-title":"Annu Rev Neurosci"},{"key":"3889_CR15","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.molcel.2003.08.013","volume":"12","author":"MD Conkright","year":"2003","unstructured":"Conkright MD, Canettieri G, Screaton R et al (2003) TORCs: transducers of regulated CREB activity. Mol Cell 12:413\u2013423. https:\/\/doi.org\/10.1016\/j.molcel.2003.08.013","journal-title":"Mol Cell"},{"key":"3889_CR16","doi-asserted-by":"publisher","first-page":"2334","DOI":"10.1523\/JNEUROSCI.2296-08.2009","volume":"29","author":"S Li","year":"2009","unstructured":"Li S, Zhang C, Takemori H et al (2009) TORC1 regulates activity-dependent CREB-target gene transcription and dendritic growth of developing cortical neurons. J Neurosci 29:2334\u20132343. https:\/\/doi.org\/10.1523\/JNEUROSCI.2296-08.2009","journal-title":"J Neurosci"},{"key":"3889_CR17","doi-asserted-by":"publisher","first-page":"2880","DOI":"10.1038\/sj.emboj.7601715","volume":"26","author":"K Ravnskjaer","year":"2007","unstructured":"Ravnskjaer K, Kester H, Liu Y et al (2007) Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J 26:2880\u20132889. https:\/\/doi.org\/10.1038\/sj.emboj.7601715","journal-title":"EMBO J"},{"key":"3889_CR18","doi-asserted-by":"publisher","first-page":"6763","DOI":"10.1073\/pnas.100110097","volume":"97","author":"JS Steffan","year":"2000","unstructured":"Steffan JS, Kazantsev A, Spasic-Boskovic O et al (2000) The Huntington\u2019s disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc Natl Acad Sci 97:6763\u20136768. https:\/\/doi.org\/10.1073\/pnas.100110097","journal-title":"Proc Natl Acad Sci"},{"key":"3889_CR19","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/j.neuron.2004.06.002","volume":"42","author":"E Korzus","year":"2004","unstructured":"Korzus E, Rosenfeld MG, Mayford M (2004) CBP histone acetyltransferase activity is a critical component of memory consolidation. Neuron 42:961\u2013972. https:\/\/doi.org\/10.1016\/j.neuron.2004.06.002","journal-title":"Neuron"},{"key":"3889_CR20","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.mcn.2005.05.003","volume":"30","author":"S-Y Cong","year":"2005","unstructured":"Cong S-Y, Pepers BA, Evert BO et al (2005) Mutant huntingtin represses CBP, but not p300, by binding and protein degradation. Mol Cell Neurosci 30:12\u201323. https:\/\/doi.org\/10.1016\/j.mcn.2005.05.003","journal-title":"Mol Cell Neurosci"},{"key":"3889_CR21","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1007\/s00018-007-7035-9","volume":"64","author":"BE Morrison","year":"2007","unstructured":"Morrison BE, Majdzadeh N, D\u2019Mello SR (2007) Histone deacetylases: focus on the nervous system. Cell Mol Life Sci 64:2258\u20132269. https:\/\/doi.org\/10.1007\/s00018-007-7035-9","journal-title":"Cell Mol Life Sci"},{"key":"3889_CR22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.coph.2007.12.002","volume":"8","author":"T Abel","year":"2008","unstructured":"Abel T, Zukin RS (2008) Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders. Curr Opin Pharmacol 8:57\u201364. https:\/\/doi.org\/10.1016\/j.coph.2007.12.002","journal-title":"Curr Opin Pharmacol"},{"key":"3889_CR23","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/j.nbd.2012.01.016","volume":"46","author":"H Jia","year":"2012","unstructured":"Jia H, Pallos J, Jacques V et al (2012) Histone deacetylase (HDAC) inhibitors targeting HDAC3 and HDAC1 ameliorate polyglutamine-elicited phenotypes in model systems of Huntington\u2019s disease. Neurobiol Dis 46:351\u2013361. https:\/\/doi.org\/10.1016\/j.nbd.2012.01.016","journal-title":"Neurobiol Dis"},{"key":"3889_CR24","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/dneu.20774","volume":"70","author":"S Cohen-Cory","year":"2010","unstructured":"Cohen-Cory S, Kidane AH, Shirkey NJ, Marshak S (2010) Brain-derived neurotrophic factor and the development of structural neuronal connectivity. Dev Neurobiol 70:271\u2013288. https:\/\/doi.org\/10.1002\/dneu.20774","journal-title":"Dev Neurobiol"},{"key":"3889_CR25","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.tins.2010.02.001","volume":"33","author":"E Benito","year":"2010","unstructured":"Benito E, Barco A (2010) CREB\u2019s control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models. Trends Neurosci 33:230\u2013240. https:\/\/doi.org\/10.1016\/j.tins.2010.02.001","journal-title":"Trends Neurosci"},{"key":"3889_CR26","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1016\/j.cell.2015.05.032","volume":"161","author":"R Madabhushi","year":"2015","unstructured":"Madabhushi R, Gao F, Pfenning AR et al (2015) Activity-induced DNA breaks govern the expression of neuronal early-response genes. Cell 161:1592\u20131605. https:\/\/doi.org\/10.1016\/j.cell.2015.05.032","journal-title":"Cell"},{"key":"3889_CR27","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1093\/hmg\/9.19.2799","volume":"9","author":"F Trettel","year":"2000","unstructured":"Trettel F, Rigamonti D, Hilditch-Maguire P et al (2000) Dominant phenotypes produced by the HD mutation in STHdhQ111 striatal cells. Hum Mol Genet 9:2799\u20132809. https:\/\/doi.org\/10.1093\/hmg\/9.19.2799","journal-title":"Hum Mol Genet"},{"key":"3889_CR28","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.freeradbiomed.2015.09.024","volume":"89","author":"A Covarrubias-Pinto","year":"2015","unstructured":"Covarrubias-Pinto A, Moll P, Sol\u00eds-Maldonado M et al (2015) Beyond the redox imbalance: oxidative stress contributes to an impaired GLUT3 modulation in Huntington\u2019s disease. Free Radic Biol Med 89:1085\u20131096. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.09.024","journal-title":"Free Radic Biol Med"},{"key":"3889_CR29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1471-4159.2010.07080.x","volume":"116","author":"K Sakamoto","year":"2011","unstructured":"Sakamoto K, Karelina K, Obrietan K (2011) CREB: a multifaceted regulator of neuronal plasticity and protection. J Neurochem 116:1\u20139. https:\/\/doi.org\/10.1111\/j.1471-4159.2010.07080.x","journal-title":"J Neurochem"},{"key":"3889_CR30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s11010-016-2858-z","volume":"425","author":"N Pregi","year":"2017","unstructured":"Pregi N, Belluscio LM, Berardino BG et al (2017) Oxidative stress-induced CREB upregulation promotes DNA damage repair prior to neuronal cell death protection. Mol Cell Biochem 425:9\u201324. https:\/\/doi.org\/10.1007\/s11010-016-2858-z","journal-title":"Mol Cell Biochem"},{"issue":"13","key":"3889_CR31","doi-asserted-by":"publisher","first-page":"6748","DOI":"10.3390\/ijms22136748","volume":"22","author":"H Wang","year":"2021","unstructured":"Wang H, Lautrup S, Caponio D et al (2021) DNA damage-induced neurodegeneration in accelerated ageing and Alzheimer\u2019s disease. Int J Mol Sci 22(13):6748","journal-title":"Int J Mol Sci"},{"key":"3889_CR32","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1007\/s13311-019-00768-7","volume":"16","author":"T Maiuri","year":"2019","unstructured":"Maiuri T, Suart CE, Hung CLK et al (2019) DNA damage repair in Huntington\u2019s disease and other neurodegenerative diseases. Neurotherapeutics 16:948\u2013956. https:\/\/doi.org\/10.1007\/s13311-019-00768-7","journal-title":"Neurotherapeutics"},{"key":"3889_CR33","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/jnr.24592","volume":"99","author":"CP Gonzalez-Hunt","year":"2021","unstructured":"Gonzalez-Hunt CP, Sanders LH (2021) DNA damage and repair in Parkinson\u2019s disease: recent advances and new opportunities. J Neurosci Res 99:180\u2013189. https:\/\/doi.org\/10.1002\/jnr.24592","journal-title":"J Neurosci Res"},{"key":"3889_CR34","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0140-6736(80)90550-4","volume":"315","author":"AN Moshell","year":"1980","unstructured":"Moshell AN, Barrett SF, Tarone RE, Robbins JH (1980) Radiosensitivity in Huntington\u2019s disease: implications for pathogenesis and presymptomatic diagnosis. Lancet 315:9\u201311. https:\/\/doi.org\/10.1016\/S0140-6736(80)90550-4","journal-title":"Lancet"},{"key":"3889_CR35","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/0022-510X(84)90051-0","volume":"64","author":"SH Robison","year":"1984","unstructured":"Robison SH, Bradley WG (1984) DNA damage and chronic neuronal degenerations. J Neurol Sci 64:11\u201320. https:\/\/doi.org\/10.1016\/0022-510X(84)90051-0","journal-title":"J Neurol Sci"},{"key":"3889_CR36","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.031930","author":"TH Massey","year":"2018","unstructured":"Massey TH, Jones L (2018) The central role of DNA damage and repair in CAG repeat diseases. Dis Model Mech. https:\/\/doi.org\/10.1242\/dmm.031930","journal-title":"Dis Model Mech"},{"key":"3889_CR37","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1083\/jcb.200905138","volume":"189","author":"Y Enokido","year":"2010","unstructured":"Enokido Y, Tamura T, Ito H et al (2010) Mutant huntingtin impairs Ku70-mediated DNA repair. J Cell Biol 189:425\u2013443. https:\/\/doi.org\/10.1083\/jcb.200905138","journal-title":"J Cell Biol"},{"key":"3889_CR38","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3233\/JHD-200438","volume":"10","author":"RR Iyer","year":"2021","unstructured":"Iyer RR, Pluciennik A (2021) DNA mismatch repair and its role in Huntington\u2019s disease. J Huntingtons Dis 10:75\u201394. https:\/\/doi.org\/10.3233\/JHD-200438","journal-title":"J Huntingtons Dis"},{"key":"3889_CR39","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/S0166-2236(00)01609-X","volume":"23","author":"J-HJ Cha","year":"2000","unstructured":"Cha J-HJ (2000) Transcriptional dysregulation in Huntington\u2019s disease. Trends Neurosci 23:387\u2013392. https:\/\/doi.org\/10.1016\/S0166-2236(00)01609-X","journal-title":"Trends Neurosci"},{"key":"3889_CR40","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0168-9525(03)00074-X","volume":"19","author":"KL Sugars","year":"2003","unstructured":"Sugars KL, Rubinsztein DC (2003) Transcriptional abnormalities in Huntington disease. Trends Genet 19:233\u2013238. https:\/\/doi.org\/10.1016\/S0168-9525(03)00074-X","journal-title":"Trends Genet"},{"key":"3889_CR41","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1126\/science.1059581","volume":"293","author":"C Zuccato","year":"2001","unstructured":"Zuccato C, Ciammola A, Rigamonti D et al (2001) Loss of huntingtin-mediated BDNF gene transcription in Huntington\u2019s disease. Science 293:493\u2013498. https:\/\/doi.org\/10.1126\/science.1059581","journal-title":"Science"},{"key":"3889_CR42","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.phrs.2005.01.001","volume":"52","author":"C Zuccato","year":"2005","unstructured":"Zuccato C, Liber D, Ramos C et al (2005) Progressive loss of BDNF in a mouse model of Huntington\u2019s disease and rescue by BDNF delivery. Pharmacol Res 52:133\u2013139. https:\/\/doi.org\/10.1016\/j.phrs.2005.01.001","journal-title":"Pharmacol Res"},{"key":"3889_CR43","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.pneurobio.2007.01.003","volume":"81","author":"C Zuccato","year":"2007","unstructured":"Zuccato C, Cattaneo E (2007) Role of brain-derived neurotrophic factor in Huntington\u2019s disease. Prog Neurobiol 81:294\u2013330. https:\/\/doi.org\/10.1016\/j.pneurobio.2007.01.003","journal-title":"Prog Neurobiol"},{"key":"3889_CR44","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.111079","author":"NAG dos Santos","year":"2020","unstructured":"dos Santos NAG, Ferreira RS, dos Santos AC (2020) Overview of cisplatin-induced neurotoxicity and ototoxicity, and the protective agents. Food Chem Toxicol. https:\/\/doi.org\/10.1016\/j.fct.2019.111079","journal-title":"Food Chem Toxicol"},{"key":"3889_CR45","doi-asserted-by":"publisher","first-page":"2343","DOI":"10.3892\/or.2013.2731","volume":"30","author":"Y-X Sun","year":"2013","unstructured":"Sun Y-X, Yang J, Wang P-Y et al (2013) Cisplatin regulates SH-SY5Y cell growth through downregulation of BDNF via miR-16. Oncol Rep 30:2343\u20132349. https:\/\/doi.org\/10.3892\/or.2013.2731","journal-title":"Oncol Rep"},{"key":"3889_CR46","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1111\/jnc.13978","volume":"141","author":"NF Abdelkader","year":"2017","unstructured":"Abdelkader NF, Saad MA, Abdelsalam RM (2017) Neuroprotective effect of nebivolol against cisplatin-associated depressive-like behavior in rats. J Neurochem 141:449\u2013460. https:\/\/doi.org\/10.1111\/jnc.13978","journal-title":"J Neurochem"},{"key":"3889_CR47","doi-asserted-by":"publisher","first-page":"15574","DOI":"10.1038\/s41598-017-15773-z","volume":"7","author":"M Han","year":"2017","unstructured":"Han M, Ban J-J, Bae J-S et al (2017) UV irradiation to mouse skin decreases hippocampal neurogenesis and synaptic protein expression via HPA axis activation. Sci Rep 7:15574. https:\/\/doi.org\/10.1038\/s41598-017-15773-z","journal-title":"Sci Rep"},{"key":"3889_CR48","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.tins.2006.08.005","volume":"29","author":"JF Disterhoft","year":"2006","unstructured":"Disterhoft JF, Oh MM (2006) Learning, aging and intrinsic neuronal plasticity. Trends Neurosci 29:587\u2013599. https:\/\/doi.org\/10.1016\/j.tins.2006.08.005","journal-title":"Trends Neurosci"},{"key":"3889_CR49","doi-asserted-by":"publisher","first-page":"2423","DOI":"10.1126\/science.1056784","volume":"291","author":"FC Nucifora","year":"2001","unstructured":"Nucifora FC, Sasaki M, Peters MF et al (2001) Interference by huntingtin and atrophin-1 with CBP-mediated transcription leading to cellular toxicity. Science 291:2423\u20132428. https:\/\/doi.org\/10.1126\/science.1056784","journal-title":"Science"},{"key":"3889_CR50","doi-asserted-by":"publisher","first-page":"14379","DOI":"10.1073\/pnas.0606714103","volume":"103","author":"Z Wu","year":"2006","unstructured":"Wu Z, Huang X, Feng Y et al (2006) Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1\u03b1 transcription and mitochondrial biogenesis in muscle cells. Proc Natl Acad Sci 103:14379\u201314384. https:\/\/doi.org\/10.1073\/pnas.0606714103","journal-title":"Proc Natl Acad Sci"},{"key":"3889_CR51","doi-asserted-by":"publisher","first-page":"3474","DOI":"10.1093\/hmg\/dds178","volume":"21","author":"RK Chaturvedi","year":"2012","unstructured":"Chaturvedi RK, Hennessey T, Johri A et al (2012) Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington\u2019s disease. Hum Mol Genet 21:3474\u20133488. https:\/\/doi.org\/10.1093\/hmg\/dds178","journal-title":"Hum Mol Genet"},{"key":"3889_CR52","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1101\/lm.917508","volume":"15","author":"RM Barrett","year":"2008","unstructured":"Barrett RM, Wood MA (2008) Beyond transcription factors: The role of chromatin modifying enzymes in regulating transcription required for memory. Learn Mem 15:460\u2013467. https:\/\/doi.org\/10.1101\/lm.917508","journal-title":"Learn Mem"},{"key":"3889_CR53","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1126\/science.1186088","volume":"328","author":"S Peleg","year":"2010","unstructured":"Peleg S, Sananbenesi F, Zovoilis A et al (2010) Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 328:753\u2013756. https:\/\/doi.org\/10.1126\/science.1186088","journal-title":"Science"},{"key":"3889_CR54","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.nlm.2011.02.015","volume":"96","author":"ED Nelson","year":"2011","unstructured":"Nelson ED, Monteggia LM (2011) Epigenetics in the mature mammalian brain: effects on behavior and synaptic transmission. Neurobiol Learn Mem 96:53\u201360. https:\/\/doi.org\/10.1016\/j.nlm.2011.02.015","journal-title":"Neurobiol Learn Mem"},{"key":"3889_CR55","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature07925","volume":"459","author":"J-S Guan","year":"2009","unstructured":"Guan J-S, Haggarty SJ, Giacometti E et al (2009) HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 459:55\u201360. https:\/\/doi.org\/10.1038\/nature07925","journal-title":"Nature"},{"key":"3889_CR56","doi-asserted-by":"publisher","first-page":"5107","DOI":"10.1007\/s12035-016-0047-4","volume":"54","author":"S Srivas","year":"2017","unstructured":"Srivas S, Thakur MK (2017) Epigenetic regulation of neuronal immediate early genes is associated with decline in their expression and memory consolidation in scopolamine-induced amnesic mice. Mol Neurobiol 54:5107\u20135119. https:\/\/doi.org\/10.1007\/s12035-016-0047-4","journal-title":"Mol Neurobiol"},{"key":"3889_CR57","doi-asserted-by":"publisher","first-page":"2432","DOI":"10.1007\/s12035-017-0490-x","volume":"55","author":"P Singh","year":"2018","unstructured":"Singh P, Thakur MK (2018) Histone deacetylase 2 inhibition attenuates downregulation of hippocampal plasticity gene expression during aging. Mol Neurobiol 55:2432\u20132442. https:\/\/doi.org\/10.1007\/s12035-017-0490-x","journal-title":"Mol Neurobiol"},{"key":"3889_CR58","doi-asserted-by":"publisher","first-page":"13066","DOI":"10.1523\/JNEUROSCI.2378-10.2010","volume":"30","author":"G Chen","year":"2010","unstructured":"Chen G, Zou X, Watanabe H et al (2010) CREB binding protein is required for both short-term and long-term memory formation. J Neurosci 30:13066\u201313077. https:\/\/doi.org\/10.1523\/JNEUROSCI.2378-10.2010","journal-title":"J Neurosci"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-023-03889-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-023-03889-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-023-03889-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T03:23:30Z","timestamp":1683861810000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-023-03889-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,15]]},"references-count":58,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["3889"],"URL":"https:\/\/doi.org\/10.1007\/s11064-023-03889-w","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,15]]},"assertion":[{"value":"17 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 February 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest. The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}