{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T16:26:56Z","timestamp":1782750416036,"version":"3.54.5"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Innovation and Entrepreneurship Training Program for College Students in Jiangsu Province","award":["202210304158Y"],"award-info":[{"award-number":["202210304158Y"]}]},{"name":"the Postgraduate Research and Practice Innovation Program of Jiangsu Province","award":["KYCX20-2855"],"award-info":[{"award-number":["KYCX20-2855"]}]},{"DOI":"10.13039\/501100001809","name":"the Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81974216"],"award-info":[{"award-number":["81974216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Natural Science Foundation of Jiangsu Province","award":["BK20221375"],"award-info":[{"award-number":["BK20221375"]}]},{"name":"the Six Phase of Jiangsu 333 High-Level Talent Training Project","award":["2022: 3-16-661"],"award-info":[{"award-number":["2022: 3-16-661"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1007\/s11064-023-03974-0","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T07:02:36Z","timestamp":1687762956000},"page":"3160-3176","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Intranasal Monophosphoryl Lipid a Administration Ameliorates depression-like Behavior in Chronically Stressed Mice Through Stimulation of Microglia"],"prefix":"10.1007","volume":"48","author":[{"given":"Meng","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingran","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxie","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"3974_CR1","doi-asserted-by":"publisher","first-page":"4772","DOI":"10.3390\/ijms24054772","volume":"24","author":"L Dobrek","year":"2023","unstructured":"Dobrek L, G\u0142owacka K (2023) Depression and its phytopharmacotherapy-a narrative review. Int J Mol Sci 24:4772","journal-title":"Int J Mol Sci"},{"key":"3974_CR2","doi-asserted-by":"publisher","first-page":"802581","DOI":"10.3389\/fpsyt.2021.802581","volume":"12","author":"F Vahid-Ansari","year":"2021","unstructured":"Vahid-Ansari F, Albert PR (2021) Rewiring of the serotonin system in major depression. Front Psychiatr 12:802581","journal-title":"Front Psychiatr"},{"key":"3974_CR3","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1080\/14740338.2022.2049753","volume":"21","author":"J Winter","year":"2022","unstructured":"Winter J, Curtis K, Hu B, Clayton AH (2022) Sexual dysfunction with major depressive disorder and antidepressant treatments: impact, assessment, and management. Expert Opin Drug Saf 21:913\u2013930","journal-title":"Expert Opin Drug Saf"},{"key":"3974_CR4","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1080\/14656566.2019.1614562","volume":"20","author":"E Brietzke","year":"2019","unstructured":"Brietzke E, Vazquez GH, Kang MJY, Soares CN (2019) Pharmacological treatment for insomnia in patients with major depressive disorder. Expert Opin Pharmacother 20:1341\u20131349","journal-title":"Expert Opin Pharmacother"},{"issue":"Suppl 3","key":"3974_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00406-008-3002-1","volume":"258","author":"HJ M\u00f6ller","year":"2008","unstructured":"M\u00f6ller HJ, Baldwin DS, Goodwin G, Kasper S, Okasha A, Stein DJ, Tandon R, Versiani M, WPA Section on Pharmacopsychiatry (2008) Do SSRIs or antidepressants in general increase suicidality? WPA Section on pharmacopsychiatry: consensus statement. Eur Arch Psychiatry Clin Neurosci 258(Suppl 3):3\u201323","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"3974_CR6","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s12974-022-02492-0","volume":"19","author":"H Wang","year":"2022","unstructured":"Wang H, He Y, Sun Z, Ren S, Liu M, Wang G, Yang J (2022) Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression. J Neuroinflamm 19:132","journal-title":"J Neuroinflamm"},{"key":"3974_CR7","doi-asserted-by":"publisher","first-page":"100356","DOI":"10.1016\/j.ynstr.2021.100356","volume":"15","author":"A Nieto-Quero","year":"2021","unstructured":"Nieto-Quero A, Chaves-Pe\u00f1a P, Sant\u00edn LJ, P\u00e9rez-Mart\u00edn M, Pedraza C (2021) Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? a systematic review in animal models. Neurobiol Stress 15:100356","journal-title":"Neurobiol Stress"},{"key":"3974_CR8","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.1038\/s41380-022-01520-y","volume":"27","author":"AN Tartt","year":"2022","unstructured":"Tartt AN, Mariani MB, Hen R, Mann JJ, Boldrini M (2022) Dysregulation of adult hippocampal neuroplasticity in major depression: pathogenesis and therapeutic implications. Mol Psychiatr 27:2689\u20132699","journal-title":"Mol Psychiatr"},{"key":"3974_CR9","doi-asserted-by":"publisher","first-page":"106625","DOI":"10.1016\/j.phrs.2022.106625","volume":"187","author":"CY Xia","year":"2023","unstructured":"Xia CY, Guo YX, Lian WW, Yan Y, Ma BZ, Cheng YC, Xu JK, He J, Zhang WK (2023) The NLRP3 inflammasome in depression: potential mechanisms and therapies. Pharmacol Res 187:106625","journal-title":"Pharmacol Res"},{"key":"3974_CR10","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.neuropharm.2011.01.043","volume":"60","author":"YC Chung","year":"2011","unstructured":"Chung YC, Kim SR, Park JY, Chung ES, Park KW, Won SY, Bok E, Jin M, Park ES, Yoon SH, Ko HW, Kim YS, Jin BK (2011) Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation. Neuropharmacology 60:963\u2013974","journal-title":"Neuropharmacology"},{"key":"3974_CR11","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1089\/neu.2021.0355","volume":"39","author":"M Shi","year":"2022","unstructured":"Shi M, Mi L, Li F, Li Y, Zhou Y, Chen F, Liu L, Chai Y, Yang W, Zhang J, Chen X (2022) Fluvoxamine confers neuroprotection via inhibiting infiltration of peripheral leukocytes and M1 polarization of microglia\/macrophages in a mouse model of traumatic brain Injury. J Neurotrauma 39:1240\u20131261","journal-title":"J Neurotrauma"},{"key":"3974_CR12","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1093\/ije\/dyp199","volume":"38","author":"OP Almeida","year":"2009","unstructured":"Almeida OP, Norman PE, Allcock R, van Bockxmeer F, Hankey GJ, Jamrozik K, Flicker L (2009) Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: the health in men Study. Int J Epidemiol 38:1049\u20131059","journal-title":"Int J Epidemiol"},{"key":"3974_CR13","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/j.pnpbp.2010.05.019","volume":"34","author":"L Carboni","year":"2010","unstructured":"Carboni L, Becchi S, Piubelli C, Mallei A, Giambelli R, Razzoli M, Math\u00e9 AA, Popoli M, Domenici E (2010) Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression. Prog Neuropsychopharmacol Biol Psychiatr 34:1037\u20131048","journal-title":"Prog Neuropsychopharmacol Biol Psychiatr"},{"key":"3974_CR14","doi-asserted-by":"publisher","first-page":"9262","DOI":"10.1073\/pnas.1104836108","volume":"108","author":"JL Warner-Schmidt","year":"2011","unstructured":"Warner-Schmidt JL, Vanover KE, Chen EY, Marshall JJ, Greengard P (2011) Antidepressant effects of selective serotonin reuptake inhibitors (SSRIs) are attenuated by antiinflammatory drugs in mice and humans. Proc Natl Acad Sci U S A 108:9262\u20139267","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3974_CR15","doi-asserted-by":"publisher","first-page":"2698","DOI":"10.1007\/s11064-017-2270-4","volume":"42","author":"L Tong","year":"2017","unstructured":"Tong L, Gong Y, Wang P, Hu W, Wang J, Chen Z, Zhang W, Huang C (2017) Microglia loss contributes to the development of major depression Induced by different types of chronic stresses. Neurochem Res 42:2698\u20132711","journal-title":"Neurochem Res"},{"key":"3974_CR16","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/mp.2013.155","volume":"19","author":"T Kreisel","year":"2014","unstructured":"Kreisel T, Frank MG, Licht T, Reshef R, Ben-Menachem-Zidon O, Baratta MV, Maier SF, Yirmiya R (2014) Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Mol Psychiatry 19:699\u2013709","journal-title":"Mol Psychiatry"},{"key":"3974_CR17","doi-asserted-by":"publisher","first-page":"109931","DOI":"10.1016\/j.pnpbp.2020.109931","volume":"101","author":"Z Cai","year":"2020","unstructured":"Cai Z, Ye T, Xu X, Gao M, Zhang Y, Wang D, Gu Y, Zhu H, Tong L, Lu J, Chen Z, Huang C (2020) Antidepressive properties of microglial stimulation in a mouse model of depression induced by chronic unpredictable stress. Prog Neuropsychopharmacol Biol Psychiatry 101:109931","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3974_CR18","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.neuroscience.2006.01.041","volume":"139","author":"LT Loftus","year":"2006","unstructured":"Loftus LT, Li HF, Gray AJ, Hirata-Fukae C, Stoica BA, Futami J, Yamada H, Aisen PS, Matsuoka Y (2006) In vivo protein transduction to the CNS. Neuroscience 139:1061\u20131067","journal-title":"Neuroscience"},{"key":"3974_CR19","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1211\/0022357022539","volume":"56","author":"L Illum","year":"2004","unstructured":"Illum L (2004) Is nose-to-brain transport of drugs in man a reality? J Pharm Pharmacol 56:3\u201317","journal-title":"J Pharm Pharmacol"},{"key":"3974_CR20","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S0021-9673(97)00041-1","volume":"767","author":"SR Hagen","year":"1997","unstructured":"Hagen SR, Thompson JD, Snyder DS, Myers KR (1997) Analysis of a monophosphoryl lipid a immunostimulant preparation from Salmonella minnesota R595 by high-performance liquid chromatography. J Chromatogr A 767:53\u201361","journal-title":"J Chromatogr A"},{"key":"3974_CR21","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1111\/all.12675","volume":"70","author":"S Sch\u00fclke","year":"2015","unstructured":"Sch\u00fclke S, Flaczyk A, Vogel L, Gaudenzio N, Angers I, L\u00f6schner B, Wolfheimer S, Spreitzer I, Qureshi S, Tsai M, Galli S, Vieths S, Scheurer S (2015) MPLA shows attenuated pro-inflammatory properties and diminished capacity to activate mast cells in comparison with LPS. Allergy 70:1259\u20131268","journal-title":"Allergy"},{"key":"3974_CR22","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1097\/SHK.0000000000000042","volume":"40","author":"JK Bohannon","year":"2013","unstructured":"Bohannon JK, Hernandez A, Enkhbaatar P, Adams WL, Sherwood ER (2013) The immunobiology of toll-like receptor 4 agonists: from endotoxin tolerance to immunoadjuvants. Shock 40:451\u2013462","journal-title":"Shock"},{"key":"3974_CR23","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.bbr.2018.02.045","volume":"347","author":"SM Hosseini","year":"2018","unstructured":"Hosseini SM, Gholami Pourbadie H, Sayyah M, Zibaii MI, Naderi N (2018) Neuroprotective effect of monophosphoryl lipid A, a detoxified lipid a derivative, in photothrombotic model of unilateral selective hippocampal ischemia in rat. Behav Brain Res 347:26\u201336","journal-title":"Behav Brain Res"},{"key":"3974_CR24","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12974-021-02377-8","volume":"19","author":"F Li","year":"2022","unstructured":"Li F, Xiang H, Gu Y, Ye T, Lu X, Huang C (2022) Innate immune stimulation by monophosphoryl lipid A prevents chronic social defeat stress-induced anxiety-like behaviors in mice. J Neuroinflammation 19:12","journal-title":"J Neuroinflammation"},{"key":"3974_CR25","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1093\/ijnp\/pyab097","volume":"25","author":"F Li","year":"2022","unstructured":"Li F, Lu X, Ma Y, Gu Y, Ye T, Huang C (2022) Monophosphoryl lipid a tolerance against chronic stress-induced depression-like behaviors in mice. Int J Neuropsychopharmacol 25:399\u2013411","journal-title":"Int J Neuropsychopharmacol"},{"key":"3974_CR26","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s12031-018-1249-1","volume":"67","author":"N Yousefi","year":"2019","unstructured":"Yousefi N, Sotoodehnejadnematalahi F, Heshmati-Fakhr N, Sayyah M, Hoseini M, Ghassemi S, Aliakbari S, Pourbadie HG (2019) Prestimulation of microglia through TLR4 pathway promotes interferon beta expression in a rat model of alzheimer\u2019s disease. J Mol Neurosci 67:495\u2013503","journal-title":"J Mol Neurosci"},{"key":"3974_CR27","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.jaci.2006.05.030","volume":"118","author":"A KleinJan","year":"2006","unstructured":"KleinJan A, Willart M, van Rijt LS, Braunstahl GJ, Leman K, Jung S, Hoogsteden HC, Lambrecht BN (2006) An essential role for dendritic cells in human and experimental allergic rhinitis. J Allergy Clin Immunol 118:1117\u20131125","journal-title":"J Allergy Clin Immunol"},{"key":"3974_CR28","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.bbi.2008.07.005","volume":"23","author":"J Mika","year":"2009","unstructured":"Mika J, Wawrzczak-Bargiela A, Osikowicz M, Makuch W, Przewlocka B (2009) Attenuation of morphine tolerance by minocycline and pentoxifylline in naive and neuropathic mice. Brain Behav Immun 23:75\u201384","journal-title":"Brain Behav Immun"},{"key":"3974_CR29","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.bbi.2020.11.002","volume":"91","author":"Y Gu","year":"2021","unstructured":"Gu Y, Ye T, Tan P, Tong L, Ji J, Gu Y, Shen Z, Shen X, Lu X, Huang C (2021) Tolerance-inducing effect and properties of innate immune stimulation on chronic stress-induced behavioral abnormalities in mice. Brain Behav Immun 91:451\u2013471","journal-title":"Brain Behav Immun"},{"key":"3974_CR30","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.iac.2009.02.002","volume":"29","author":"R Dantzer","year":"2009","unstructured":"Dantzer R (2009) Cytokine, sickness behavior, and depression. Immunol Allergy Clin North Am 29:247\u2013264","journal-title":"Immunol Allergy Clin North Am"},{"key":"3974_CR31","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13024-017-0195-7","volume":"12","author":"S Venezia","year":"2017","unstructured":"Venezia S, Refolo V, Polissidis A, Stefanis L, Wenning GK, Stefanova N (2017) Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal \u03b1-synucleinopathy. Mol Neurodegener 12:52","journal-title":"Mol Neurodegener"},{"key":"3974_CR32","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1073\/pnas.1215165110","volume":"110","author":"JP Michaud","year":"2013","unstructured":"Michaud JP, Hall\u00e9 M, Lampron A, Th\u00e9riault P, Pr\u00e9fontaine P, Filali M, Tribout-Jover P, Lanteigne AM, Jodoin R, Cluff C, Brichard V, Palmantier R, Pilorget A, Larocque D, Rivest S (2013) Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves alzheimer\u2019s disease-related pathology. Proc Natl Acad Sci 110:1941\u20131946","journal-title":"Proc Natl Acad Sci"},{"key":"3974_CR33","doi-asserted-by":"publisher","first-page":"101971","DOI":"10.1016\/j.pneurobio.2020.101971","volume":"200","author":"R Martins-Ferreira","year":"2021","unstructured":"Martins-Ferreira R, Leal B, Costa PP, Ballestar E (2021) Microglial innate memory and epigenetic reprogramming in neurological disorders. Prog Neurobiol 200:101971","journal-title":"Prog Neurobiol"},{"key":"3974_CR34","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-981-19-7376-5_1","volume":"1411","author":"SW Jeon","year":"2023","unstructured":"Jeon SW, Kim YK (2023) Neuron-microglia crosstalk in neuropsychiatric disorders. Adv Exp Med Biol 1411:3\u201315","journal-title":"Adv Exp Med Biol"},{"key":"3974_CR35","doi-asserted-by":"publisher","first-page":"6409","DOI":"10.1007\/s12035-019-1529-y","volume":"56","author":"K Koss","year":"2019","unstructured":"Koss K, Churchward MA, Tsui C, Todd KG (2019) In vitro priming and hyper-activation of brain microglia: an assessment of phenotypes. Mol Neurobiol 56:6409\u20136425","journal-title":"Mol Neurobiol"},{"key":"3974_CR36","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.bbi.2021.03.016","volume":"95","author":"Z Wu","year":"2021","unstructured":"Wu Z, Zhou L, Sun L, Xie Y, Xiao L, Wang H, Wang G (2021) Brief postpartum separation from offspring promotes resilience to lipopolysaccharide challenge-induced anxiety and depressive-like behaviors and inhibits neuroinflammation in C57BL\/6J dams. Brain Behav Immun 95:190\u2013202","journal-title":"Brain Behav Immun"},{"key":"3974_CR37","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1016\/j.psyneuen.2012.02.003","volume":"37","author":"ES Wohleb","year":"2012","unstructured":"Wohleb ES, Fenn AM, Pacenta AM, Powell ND, Sheridan JF, Godbout JP (2012) Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice. Psychoneuroendocrinology 37:1491\u20131505","journal-title":"Psychoneuroendocrinology"},{"key":"3974_CR38","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.biologicals.2020.08.007","volume":"68","author":"A Azimi","year":"2020","unstructured":"Azimi A, Heidarian S, Zamani H, Taleghani N, Dehghani M, Seyedjafari E (2020) Optimized dose of synthetic analogues of monophosphoryl lipid A as an effective alternative for formulating recombinant human papillomavirus vaccine. Biologicals 68:60\u201364","journal-title":"Biologicals"},{"key":"3974_CR39","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1038\/s41419-020-2644-4","volume":"11","author":"Z He","year":"2020","unstructured":"He Z, Yang Y, Xing Z, Zuo Z, Wang R, Gu H, Qi F, Yao Z (2020) Intraperitoneal injection of IFN-\u03b3 restores microglial autophagy, promotes amyloid-\u03b2 clearance and improves cognition in APP\/PS1 mice. Cell Death Dis 11:440","journal-title":"Cell Death Dis"},{"key":"3974_CR40","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1038\/s41380-021-01338-0","volume":"27","author":"N Rimmerman","year":"2022","unstructured":"Rimmerman N, Verdiger H, Goldenberg H, Naggan L, Robinson E, Kozela E, Gelb S, Reshef R, Ryan KM, Ayoun L, Refaeli R, Ashkenazi E, Schottlender N, Ben Hemo-Cohen L, Pienica C, Aharonian M, Dinur E, Lazar K, McLoughlin DM, Zvi AB, Yirmiya R (2022) Microglia and their LAG3 checkpoint underlie the antidepressant and neurogenesis-enhancing effects of electroconvulsive stimulation. Mol Psychiatr 27:1120\u20131135","journal-title":"Mol Psychiatr"},{"key":"3974_CR41","doi-asserted-by":"publisher","first-page":"578019","DOI":"10.1016\/j.jneuroim.2023.578019","volume":"375","author":"CPM Pereira","year":"2023","unstructured":"Pereira CPM, Francis-Oliveira J, Singulani MP, Ferreira AFF, Britto LRG (2023) Microglial depletion exacerbates motor impairment and dopaminergic neuron loss in a 6-OHDA model of parkinson\u2019s disease. J Neuroimmunol 375:578019","journal-title":"J Neuroimmunol"},{"key":"3974_CR42","doi-asserted-by":"publisher","first-page":"114202","DOI":"10.1016\/j.expneurol.2022.114202","volume":"357","author":"M Radpour","year":"2022","unstructured":"Radpour M, Choopani S, Pourbadie HG, Sayyah M (2022) Activating toll-like receptor 4 after traumatic brain injury inhibits neuroinflammation and the accelerated development of seizures in rats. Exp Neurol 357:114202","journal-title":"Exp Neurol"},{"key":"3974_CR43","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1186\/s12967-022-03804-x","volume":"20","author":"X Guo","year":"2022","unstructured":"Guo X, Du L, Ma N, Zhang P, Wang Y, Han Y, Huang X, Zhang Q, Tan X, Lei X, Qu B (2022) Monophosphoryl lipid A ameliorates radiation-induced lung injury by promoting the polarization of macrophages to the M1 phenotype. J Transl Med 20:597","journal-title":"J Transl Med"},{"key":"3974_CR44","doi-asserted-by":"publisher","first-page":"109852","DOI":"10.1016\/j.intimp.2023.109852","volume":"117","author":"X Sun","year":"2023","unstructured":"Sun X, Hosomi K, Shimoyama A, Yoshii K, Lan H, Wang Y, Yamaura H, Nagatake T, Ishii KJ, Akira S, Kiyono H, Fukase K, Kunisawa J (2023) TLR4 agonist activity of alcaligenes lipid a utilizes MyD88 and TRIF signaling pathways for efficient antigen presentation and T cell differentiation by dendritic cells. Int Immunopharmacol 117:109852","journal-title":"Int Immunopharmacol"},{"key":"3974_CR45","doi-asserted-by":"publisher","first-page":"11706","DOI":"10.1523\/JNEUROSCI.0730-12.2012","volume":"32","author":"Z Chen","year":"2012","unstructured":"Chen Z, Jalabi W, Shpargel KB, Farabaugh KT, Dutta R, Yin X, Kidd GJ, Bergmann CC, Stohlman SA, Trapp BD (2012) Lipopolysaccharide-induced microglial activation and neuroprotection against experimental brain injury is independent of hematogenous TLR4. J Neurosci 32:11706\u201311715","journal-title":"J Neurosci"},{"key":"3974_CR46","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/s12974-021-02127-w","volume":"18","author":"T Li","year":"2021","unstructured":"Li T, Zhao J, Xie W, Yuan W, Guo J, Pang S, Gan WB, G\u00f3mez-Nicola D, Zhang S (2021) Specific depletion of resident microglia in the early stage of stroke reduces cerebral ischemic damage. J Neuroinflammation 18:81","journal-title":"J Neuroinflammation"},{"key":"3974_CR47","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.bbi.2020.06.028","volume":"89","author":"W Wu","year":"2020","unstructured":"Wu W, Li Y, Wei Y, Bosco DB, Xie M, Zhao MG, Richardson JR, Wu LJ (2020) Microglial depletion aggravates the severity of acute and chronic seizures in mice. Brain Behav Immun 89:245\u2013255","journal-title":"Brain Behav Immun"},{"key":"3974_CR48","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1523\/JNEUROSCI.3028-14.2015","volume":"35","author":"JC Delpech","year":"2015","unstructured":"Delpech JC, Saucisse N, Parkes SL, Lacabanne C, Aubert A, Casenave F, Coutureau E, Sans N, Lay\u00e9 S, Ferreira G, Nadjar A (2015) Microglial activation enhances associative taste memory through purinergic modulation of glutamatergic neurotransmission. J Neurosci 35:3022\u20133033","journal-title":"J Neurosci"},{"key":"3974_CR49","first-page":"E197","volume":"A109","author":"O Pascual","year":"2012","unstructured":"Pascual O, Ben Achour S, Rostaing P, Triller A, Bessis A (2012) Microglia activation triggers astrocyte-mediated modulation of excitatory neurotransmission. Proc Natl Acad Sci A109:E197\u2013E205","journal-title":"Proc Natl Acad Sci"},{"key":"3974_CR50","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1503\/jpn.160175","volume":"42","author":"LR Aleksandrova","year":"2017","unstructured":"Aleksandrova LR, Phillips AG, Wang YT (2017) Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism. J Psychiatr Neurosci 42:222\u2013229","journal-title":"J Psychiatr Neurosci"},{"key":"3974_CR51","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.neuropharm.2017.12.028","volume":"131","author":"H Yu","year":"2018","unstructured":"Yu H, Li M, Zhou D, Lv D, Liao Q, Lou Z, Shen M, Wang Z, Li M, Xiao X, Zhang Y, Wang C (2018) Vesicular glutamate transporter 1 (VGLUT1)-mediated glutamate release and membrane GluA1 activation is involved in the rapid antidepressant-like effects of scopolamine in mice. Neuropharmacology 131:209\u2013222","journal-title":"Neuropharmacology"},{"key":"3974_CR52","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/nm.3162","volume":"19","author":"X Cao","year":"2013","unstructured":"Cao X, Li LP, Wang Q, Wu Q, Hu HH, Zhang M, Fang YY, Zhang J, Li SJ, Xiong WC, Yan HC, Gao YB, Liu JH, Li XW, Sun LR, Zeng YN, Zhu XH, Gao TM (2013) Astrocyte-derived ATP modulates depressive-like behaviors. Nat Med 19:773\u2013777","journal-title":"Nat Med"},{"key":"3974_CR53","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1016\/0031-9384(91)90360-Z","volume":"49","author":"RP Heinsbroek","year":"1991","unstructured":"Heinsbroek RP, Van Haaren F, Van de Poll NE, Steenbergen HL (1991) Sex differences in the behavioral consequences of inescapable footshocks depend on time since shock. Physiol Behav 49:1257\u20131263","journal-title":"Physiol Behav"},{"key":"3974_CR54","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1210\/en.2004-0846","volume":"146","author":"V Viau","year":"2005","unstructured":"Viau V, Bingham B, Davis J, Lee P, Wong M (2005) Gender and puberty interact on the stress-induced activation of parvocellular neurosecretory neurons and corticotropin-releasing hormone messenger ribonucleic acid expression in the rat. Endocrinology 146:137\u2013146","journal-title":"Endocrinology"},{"key":"3974_CR55","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1038\/sj.npp.1301488","volume":"33","author":"LH Tonelli","year":"2008","unstructured":"Tonelli LH, Holmes A, Postolache TT (2008) Intranasal immune challenge induces sex-dependent depressive-like behavior and cytokine expression in the brain. Neuropsychopharmacology 33:1038\u20131048","journal-title":"Neuropsychopharmacology"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-023-03974-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-023-03974-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-023-03974-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T10:16:39Z","timestamp":1693476999000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-023-03974-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,26]]},"references-count":55,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["3974"],"URL":"https:\/\/doi.org\/10.1007\/s11064-023-03974-0","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,26]]},"assertion":[{"value":"4 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 June 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no conflict of interest to declare.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}