{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:38:43Z","timestamp":1780580323878,"version":"3.54.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T00:00:00Z","timestamp":1701129600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Sichuan Province Applied Basic Research Project","award":["2022NSFSC0787"],"award-info":[{"award-number":["2022NSFSC0787"]}]},{"name":"Chengdu Medical Research Project","award":["2021216"],"award-info":[{"award-number":["2021216"]}]},{"name":"Chengdu Medical Research Project","award":["202306012920"],"award-info":[{"award-number":["202306012920"]}]},{"name":"Chengdu Medical College Graduate Innovation Fund Key Project","award":["YCX2021-11"],"award-info":[{"award-number":["YCX2021-11"]}]},{"name":"Sichuan Province Medical Research Project","award":["S21007"],"award-info":[{"award-number":["S21007"]}]},{"name":"Foundation of Development and Regeneration Laboratory","award":["SYS19-05"],"award-info":[{"award-number":["SYS19-05"]}]},{"name":"Fundamental Research Funds for Central University","award":["SCU2022D006"],"award-info":[{"award-number":["SCU2022D006"]}]},{"name":"Foundation of Chengdu Medical College","award":["CYZYB20-05"],"award-info":[{"award-number":["CYZYB20-05"]}]},{"name":"Foundation of The First Affiliated Hospital of Chengdu Medical College","award":["CYFY2020YB04"],"award-info":[{"award-number":["CYFY2020YB04"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>White matter dysplasia (WMD) in preterm infants due to intrauterine inflammation is caused by excessive apoptosis of oligodendrocyte precursor cells (OPCs). In recent years, studies have found that excessive autophagy and apoptosis are highly interconnected and important in infection and inflammatory diseases in general. Therefore, in this study, we aimed to confirm whether regulation of autophagy by using the Akt phosphorylation agonist SC79 can inhibit abnormal apoptosis of OPCs and promote myelin maturation and white matter development in neonatal rats with WMD. We investigated the effect of inflammation on oligodendrocyte development in P0 neonatal rats by intracerebellar injection of LPS, and collected brain tissue at P2 and P5. Immunohistochemical and immunofluorescence staining were used to evaluate white matter damage, while immunofluorescence staining, terminal deoxynucleotidyl transferase dUTP nick end labeling analysis (TUNEL), and western blotting were used to evaluate autophagy and apoptosis. First, we observed that white matter development was arrested and white matter fiber maturation was impaired in LPS-inflicted pups compared with those in the sham-operated group. Second, treatment with SC79 reduced the levels of LC3II, caspase 3, caspase 9, and Bax\/Bcl-2 and increased the levels of p62, p-Akt, and p-mTOR in the brain tissue of neonatal rats. Finally, SC79 treatment inhibited OPC apoptosis by increasing the binding of Beclin 1 to Bcl-2, which promoted OPC differentiation and maturation. However, the opposite results were observed after rapamycin administration. Taken together, our results suggest that SC79 can inhibit the abnormal apoptosis of OPCs caused by excessive autophagy through the Akt\/mTOR pathway and that SC79 is a potential therapeutic agent for WMD in preterm infants.<\/jats:p>","DOI":"10.1007\/s11064-023-04057-w","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T11:02:49Z","timestamp":1701169369000},"page":"670-683","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Akt\/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia"],"prefix":"10.1007","volume":"49","author":[{"given":"Zhongni","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiehong","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minrong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"4057_CR1","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1007\/s00401-017-1718-6","volume":"134","author":"SA Back","year":"2017","unstructured":"Back SA (2017) White matter injury in the preterm infant: Pathology and mechanisms. Acta Neuropathol 134:331\u2013349. https:\/\/doi.org\/10.1007\/s00401-017-1718-6","journal-title":"Acta Neuropathol"},{"key":"4057_CR2","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1038\/nrneurol.2010.53","volume":"6","author":"W Deng","year":"2010","unstructured":"Deng W (2010) Neurobiology of injury to the developing brain. Nat Rev Neurol 6:328\u2013336","journal-title":"Nat Rev Neurol"},{"key":"4057_CR3","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/j.clp.2022.06.001","volume":"49","author":"A Locke","year":"2022","unstructured":"Locke A, Kanekar S (2022) Imaging of premature infants. Clin Perinatol 49:641\u2013655","journal-title":"Clin Perinatol"},{"key":"4057_CR4","doi-asserted-by":"publisher","first-page":"871265","DOI":"10.3389\/fphys.2022.871265","volume":"13","author":"JC Shaw","year":"2022","unstructured":"Shaw JC, Dyson RM, Palliser HK, Sixtus RP, Barnes H, Pavy CL, Crombie GK, Berry MJ, Hirst JJ (2022) Examining neurosteroid-analogue therapy in the preterm neonate for promoting hippocampal neurodevelopment. Front Physiol 13:871265. https:\/\/doi.org\/10.3389\/fphys.2022.871265","journal-title":"Front Physiol"},{"key":"4057_CR5","doi-asserted-by":"publisher","first-page":"113988","DOI":"10.1016\/j.expneurol.2022.113988","volume":"351","author":"JD Reiss","year":"2022","unstructured":"Reiss JD, Peterson LS, Nesamoney SN, Chang AL, Pasca AM, Mari\u0107 I, Shaw GM, Gaudilliere B, Wong RJ, Sylvester KG, Bonifacio SL, Aghaeepour N, Gibbs RS, Stevenson DK (2022) Perinatal Infection, inflammation, preterm birth, and brain injury: a review with proposals for future investigations. Exp Neurol 351:113988. https:\/\/doi.org\/10.1016\/j.expneurol.2022.113988","journal-title":"Exp Neurol"},{"key":"4057_CR6","doi-asserted-by":"publisher","first-page":"881674","DOI":"10.3389\/fphys.2022.881674","volume":"13","author":"G Favrais","year":"2022","unstructured":"Favrais G, Bokobza C, Saliba E, Chalon S, Gressens P (2022) Alteration of the oligodendrocyte lineage varies according to the systemic inflammatory stimulus in animal models that mimic the encephalopathy of prematurity. Front Physiol 13:881674. https:\/\/doi.org\/10.3389\/fphys.2022.881674","journal-title":"Front Physiol"},{"key":"4057_CR7","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.nbd.2017.12.013","volume":"111","author":"Z Zhang","year":"2018","unstructured":"Zhang Z, Jyoti A, Balakrishnan B, Williams M, Singh S, Chugani DC, Kannan S (2018) Trajectory of inflammatory and microglial activation markers in the postnatal rabbit brain following intrauterine endotoxin exposure. Neurobiol Dis 111:153\u2013162. https:\/\/doi.org\/10.1016\/j.nbd.2017.12.013","journal-title":"Neurobiol Dis"},{"key":"4057_CR8","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1620\/tjem.234.299","volume":"234","author":"R Kitanishi","year":"2014","unstructured":"Kitanishi R, Matsuda T, Watanabe S, Saito M, Hanita T, Watanabe T, Kobayashi Y (2014) Cerebral ischemia or intrauterine inflammation promotes differentiation of oligodendroglial precursors in preterm ovine fetuses: possible cellular basis for white matter injury. Tohoku J Exp Med 234:299\u2013307. https:\/\/doi.org\/10.1620\/tjem.234.299","journal-title":"Tohoku J Exp Med"},{"key":"4057_CR9","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s10571-017-0500-6","volume":"38","author":"M Peymani","year":"2018","unstructured":"Peymani M, Ghaedi K, Hashemi MS, Ghoochani A, Kiani-Esfahani A, Nasr-Esfahani MH, Baharvand H (2018) Ameliorating the effect of pioglitazone on LPS-induced inflammation of human oligodendrocyte progenitor cells. Cell Mol Neurobiol 38:517\u2013527. https:\/\/doi.org\/10.1007\/s10571-017-0500-6","journal-title":"Cell Mol Neurobiol"},{"key":"4057_CR10","doi-asserted-by":"publisher","first-page":"12466","DOI":"10.3390\/ijms222212466","volume":"22","author":"M Izadi","year":"2021","unstructured":"Izadi M, Ali TA, Pourkarimi E (2021) Over fifty years of life, death, and cannibalism: a historical recollection of apoptosis and autophagy. Int J Mol Sci 22:12466. https:\/\/doi.org\/10.3390\/ijms222212466","journal-title":"Int J Mol Sci"},{"key":"4057_CR11","doi-asserted-by":"publisher","first-page":"85","DOI":"10.3892\/ijmm.2022.5141","volume":"49","author":"C Li","year":"2022","unstructured":"Li C, Ma D, Chen Y, Liu W, Jin F, Bo L (2022) Selective inhibition of JNK located on mitochondria protects against mitochondrial dysfunction and cell death caused by endoplasmic reticulum stress in mice with LPS induced ALI\/ARDS. Int J Mol Med 49:85. https:\/\/doi.org\/10.3892\/ijmm.2022.5141","journal-title":"Int J Mol Med"},{"key":"4057_CR12","doi-asserted-by":"publisher","unstructured":"Liu R, Li J, Xu Y, Chen Z, Ye H, Tang J, Wei L, Liang L (2022) Melatonin attenuates LPS-induced proinflammatory cytokine response and lipogenesis in human meibomian gland epithelial cells via MAPK\/NF-\u03baB pathway. Invest Ophthalmol Vis Sci 63(5):6. https:\/\/doi.org\/10.1167\/iovs.63.5.6","DOI":"10.1167\/iovs.63.5.6"},{"key":"4057_CR13","doi-asserted-by":"publisher","first-page":"5940","DOI":"10.3892\/mmr.2018.8570","volume":"17","author":"L Qiao","year":"2018","unstructured":"Qiao L, Fu J, Xue X, Shi Y, Yao L, Huang W, Li J, Zhang D, Liu N, Tong X, Du Y, Pan Y (2018) Neuronalinjury and roles of apoptosis and autophagy in a neonatal rat model of hypoxia-ischemia-induced periventricular leukomalacia. Mol Med Rep 17:5940\u20135949. https:\/\/doi.org\/10.3892\/mmr.2018.8570","journal-title":"Mol Med Rep"},{"key":"4057_CR14","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/s41419-018-0916-z","volume":"9","author":"C Descloux","year":"2018","unstructured":"Descloux C, Ginet V, Rummel C, Truttmann AC, Puyal J (2018) Enhanced autophagy contributes to excitotoxic lesions in a rat model of preterm brain injury. Cell Death Dis 9:853. https:\/\/doi.org\/10.1038\/s41419-018-0916-z","journal-title":"Cell Death Dis"},{"key":"4057_CR15","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.ijbiomac.2022.02.005","volume":"204","author":"K Prerna","year":"2022","unstructured":"Prerna K, Dubey VK (2022) Beclin1-mediated interplay between autophagy and apoptosis: New understanding. Int J Biol Macromol 204:258\u2013273. https:\/\/doi.org\/10.1016\/j.ijbiomac.2022.02.005","journal-title":"Int J Biol Macromol"},{"key":"4057_CR16","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.nutres.2019.04.002","volume":"67","author":"SH Lim","year":"2019","unstructured":"Lim SH, Kim MJ, Lee J (2019) Intake of psyllium seed husk reduces white matter damage in a rat model of chronic cerebral hypoperfusion. Nutr Res 67:27\u201339. https:\/\/doi.org\/10.1016\/j.nutres.2019.04.002","journal-title":"Nutr Res"},{"key":"4057_CR17","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.molimm.2018.04.014","volume":"99","author":"QH Shao","year":"2018","unstructured":"Shao QH, Zhang XL, Chen Y, Zhu CG, Shi JG, Yuan YH, Chen NH (2018) Anti-neuroinflammatory effects of 20\u00a0C from Gastrodia Elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4\/Akt\/mTOR signaling pathways. Mol Immunol 99:115\u2013123. https:\/\/doi.org\/10.1016\/j.molimm.2018.04.014","journal-title":"Mol Immunol"},{"key":"4057_CR18","doi-asserted-by":"publisher","first-page":"147047","DOI":"10.1016\/j.brainres.2020.147047","volume":"1749","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, He Q, Yang M, Hua S, Ma Q, Guo L, Wu X, Zhang C, Fu X, Liu J (2020) Dichloromethane extraction from Piper nigrum L. and P. Longum L. to mitigate ischemic Stroke by activating the AKT\/mTOR signaling pathway to suppress autophagy. Brain Res 1749:147047. https:\/\/doi.org\/10.1016\/j.brainres.2020.147047","journal-title":"Brain Res"},{"key":"4057_CR19","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-022-01275-8","author":"L Wang","year":"2022","unstructured":"Wang L, Sun Y, Kong F, Jiang Y, An M, Jin B, Cao D, Li R, Guan X, Liang S, Abudurexiti S, Gong P (2022) Mild Hypothermia alleviates complement C5a-induced neuronal autophagy during brain ischemia\u2013reperfusion injury after Cardiac Arrest. Cell Mol Neurobiol (Online Ahead of Print). https:\/\/doi.org\/10.1007\/s10571-022-01275-8","journal-title":"Cell Mol Neurobiol (Online Ahead of Print)"},{"key":"4057_CR20","doi-asserted-by":"publisher","first-page":"2502263","DOI":"10.1155\/2022\/2502263","volume":"2022","author":"G Xu","year":"2022","unstructured":"Xu G, Ma T, Zhou C, Zhao F, Peng K, Li B (2022) Beta-carotene attenuates apoptosis and autophagy via PI3K\/AKT\/mTOR signaling pathway in necrotizing enterocolitis model cells IEC-6. Evid Based Complement Alternat Med 2022:2502263. https:\/\/doi.org\/10.1155\/2022\/2502263","journal-title":"Evid Based Complement Alternat Med"},{"key":"4057_CR21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.neuroscience.2018.01.023","volume":"405","author":"C Mallard","year":"2019","unstructured":"Mallard C, Tremblay ME, Vexler ZS (2019) Microglia and neonatal brain injury. Neuroscience 405:68\u201376. https:\/\/doi.org\/10.1016\/j.neuroscience.2018.01.023","journal-title":"Neuroscience"},{"key":"4057_CR22","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s11948-015-9659-8","volume":"22","author":"HJ Curzer","year":"2016","unstructured":"Curzer HJ, Perry G, Wallace MC, Perry D (2016) The three rs of animal research: what they mean for the Institutional Animal Care and Use Committee and why. Sci Eng Ethics 22:549\u2013565. https:\/\/doi.org\/10.1007\/s11948-015-9659-8","journal-title":"Sci Eng Ethics"},{"key":"4057_CR23","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.bbi.2019.06.032","volume":"81","author":"WC Pierre","year":"2019","unstructured":"Pierre WC, Akakpo L, Londono I, Pouliot P, Chemtob S, Lesage F, Lodygensky GA (2019) Assessing therapeutic response non-invasively in a neonatal rat model of acute inflammatory white matter injury using high-field MRI. Brain Behav Immun 81:348\u2013360. https:\/\/doi.org\/10.1016\/j.bbi.2019.06.032","journal-title":"Brain Behav Immun"},{"key":"4057_CR24","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s13287-021-02157-4","volume":"12","author":"N Zhou","year":"2021","unstructured":"Zhou N, Wang L, Fu P, Cui Z, Ge Y, Jiang F, Liu J, Ren C, Luan Z, Fan H, Yao R (2021) Conditioned medium-preconditioned EPCs enhanced the ability in oligovascular repair in cerebral ischemia neonatal rats. Stem Cell Res Ther 12:118. https:\/\/doi.org\/10.1186\/s13287-021-02157-4","journal-title":"Stem Cell Res Ther"},{"key":"4057_CR25","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.expneurol.2014.11.010","volume":"264","author":"C Juliano","year":"2015","unstructured":"Juliano C, Sosunov S, Niatsetskaya Z, Isler JA, Utkina-Sosunova I, Jang I, Ratner V, Ten V (2015) Mild intermittent hypoxemia in neonatal mice causes permanent neurofunctional deficit and white matter hypomyelination. Exp Neurol 264:33\u201342. https:\/\/doi.org\/10.1016\/j.expneurol.2014.11.010","journal-title":"Exp Neurol"},{"key":"4057_CR26","doi-asserted-by":"publisher","first-page":"52","DOI":"10.55782\/ane-2022-005","volume":"82","author":"MA Al-Griw","year":"2022","unstructured":"Al-Griw MA, Salter MG, Wood IC (2022) Blocking of NF-kB\/p38 MAPK pathways mitigates oligodendrocyte pathology in a model of neonatal white matter injury. Acta Neurobiol Exp (Wars) 82:52\u201364. https:\/\/doi.org\/10.55782\/ane-2022-005","journal-title":"Acta Neurobiol Exp (Wars)"},{"key":"4057_CR27","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.brainresbull.2022.08.014","volume":"189","author":"F Zhang","year":"2022","unstructured":"Zhang F, Gou Z, Zhou Y, Huang L, Shao C, Wang M, Wu C, Lu L (2022) MicroRNA-21-5p agomir inhibits apoptosis of oligodendrocyte precursor cell and attenuates white matter injury in neonatal rats. Brain Res Bull 189:139\u2013150. https:\/\/doi.org\/10.1016\/j.brainresbull.2022.08.014","journal-title":"Brain Res Bull"},{"key":"4057_CR28","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1152\/physrev.00011.2017","volume":"98","author":"M Fricker","year":"2018","unstructured":"Fricker M, Tolkovsky AM, Borutaite V, Coleman M, Brown GC (2018) Neuronal cell death. Physiol Rev 98:813\u2013880. https:\/\/doi.org\/10.1152\/physrev.00011.2017","journal-title":"Physiol Rev"},{"key":"4057_CR29","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.immuni.2021.01.018","volume":"54","author":"V Deretic","year":"2021","unstructured":"Deretic V (2021) Autophagy in inflammation, infection, and immunometabolism. Immunity 54:437\u2013453. https:\/\/doi.org\/10.1016\/j.immuni.2021.01.018","journal-title":"Immunity"},{"key":"4057_CR30","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1038\/s41420-022-01225-9","volume":"8","author":"S Calis","year":"2022","unstructured":"Calis S, Dogan B, Durdagi S, Celebi A, Yapicier O, Kilic T, Turanli ET, Avsar T (2022) A novel BH3 mimetic Bcl-2 inhibitor promotes autophagic cell death and reduces in vivo glioblastoma tumor growth. Cell Death Discov 8:433. https:\/\/doi.org\/10.1038\/s41420-022-01225-9","journal-title":"Cell Death Discov"},{"key":"4057_CR31","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1089\/ars.2021.0094","volume":"38","author":"C He","year":"2023","unstructured":"He C, Xu Y, Sun J, Li L, Zhang JH, Wang Y (2023) Autophagy and apoptosis in acute brain injuries: from mechanism to treatment. Antioxid Redox Signal 38:234\u2013257. https:\/\/doi.org\/10.1089\/ars.2021.0094","journal-title":"Antioxid Redox Signal"},{"key":"4057_CR32","doi-asserted-by":"publisher","first-page":"3741","DOI":"10.1007\/s12035-023-03304-z","volume":"60","author":"T Zhang","year":"2023","unstructured":"Zhang T, Wu J, Yao X, Zhang Y, Wang Y, Han Y, Wu Y, Xu Z, Lan J, Han S, Zou H, Sun Q, Wang D, Zhang J, Wang G (2023) The aldose reductase inhibitor epalrestat maintains blood-brain barrier integrity by enhancing endothelial cell function during cerebral ischemia. Mol Neurobiol 60:3741\u20133757. https:\/\/doi.org\/10.1007\/s12035-023-03304-z","journal-title":"Mol Neurobiol"},{"key":"4057_CR33","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.3390\/cells9081843","volume":"9","author":"HA Kalpage","year":"2020","unstructured":"Kalpage HA, Wan J, Morse PT, Lee I, H\u00fcttemann M (2020) Brain-specific serine-47 modification of cytochrome c regulates cytochrome c oxidase activity attenuating ROS production and cell death: implications for ischemia\/reperfusion injury and akt signaling. Cells 9:1843. https:\/\/doi.org\/10.3390\/cells9081843","journal-title":"Cells"},{"key":"4057_CR34","doi-asserted-by":"publisher","first-page":"283","DOI":"10.21203\/rs.3.rs-178207\/v1","volume":"35","author":"HH Miao","year":"2022","unstructured":"Miao HH, Liu WB, Jiao XH, Shao KJ, Yuan YX, Sha S, Zhang QQ, Yan J, Sun YY, Zhou CH, Wu YQ (2022) Neonatal exposure to propofol interferes with the proliferation and differentiation of hippocampal neural stem cells and the neurocognitive function of rats in adulthood via the Akt\/p27 signaling pathway. Biomed Environ Sci 35:283\u2013295. https:\/\/doi.org\/10.21203\/rs.3.rs-178207\/v1","journal-title":"Biomed Environ Sci"},{"key":"4057_CR35","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.2147\/DDDT.S409530","volume":"17","author":"L Yu","year":"2023","unstructured":"Yu L, Gai Y (2023) Elucidating the mechanism of agrimonolide in treating colon cancer based on network pharmacology. Drug Des Devel Ther 17:2209\u20132222. https:\/\/doi.org\/10.2147\/DDDT.S409530","journal-title":"Drug Des Devel Ther"},{"key":"4057_CR36","doi-asserted-by":"publisher","DOI":"10.1111\/cas.15928","author":"K Chen","year":"2023","unstructured":"Chen K, Li H, Li Y, Yang Z, Luo J, Zhou Z (2023) ARNTL inhibits the malignant behaviors of oral cancer by regulating autophagy in an AKT\/mTOR pathway-dependent manner. Cancer Sci https\/\/. https:\/\/doi.org\/10.1111\/cas.15928","journal-title":"Cancer Sci https\/\/"},{"issue":"3","key":"4057_CR37","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.gendis.2018.06.001","volume":"5","author":"Y Hou","year":"2018","unstructured":"Hou Y, Wang K, Wan W, Cheng Y, Pu X, Ye X (2018) Resveratrol provides neuroprotection by regulating the JAK2\/STAT3\/PI3K\/AKT\/mTOR pathway after Stroke in rats. Genes Dis 5(3):245\u2013255. https:\/\/doi.org\/10.1016\/j.gendis","journal-title":"Genes Dis"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-023-04057-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-023-04057-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-023-04057-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T06:19:49Z","timestamp":1708582789000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-023-04057-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,28]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["4057"],"URL":"https:\/\/doi.org\/10.1007\/s11064-023-04057-w","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,28]]},"assertion":[{"value":"20 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2023","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 October 2023","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2023","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}},{"value":"The animal study protocol was approved by the Ethics Committee of Chengdu Medical College (protocol code: CHENGYIDONGLUN2021007; Date of approval:01 July 2021). All animal experiments complied with the ARRIVE guidelines and were performed according to the UK Animals (Scientific Procedures) Act of 1986 and the National Research Council\u2019s Guide for the Care and Use of Laboratory Animals.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"During the preparation of this work the author(s) used [NAME TOOL\/SERVICE] in order to [REASON]. After using this tool\/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}