{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:21:20Z","timestamp":1769520080166,"version":"3.49.0"},"reference-count":130,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1007\/s11064-024-04184-y","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T04:01:53Z","timestamp":1718164913000},"page":"2336-2351","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neuroprotective Action of Selected Natural Drugs Against Neurological Diseases and Mental Disorders: Potential Use Against Radiation Damage"],"prefix":"10.1007","volume":"49","author":[{"family":"Akhlada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nazia","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Anurag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alimuddin","family":"Saifi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuradha","family":"Kesharwani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vipan Kumar","family":"Parihar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alok","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"key":"4184_CR1","doi-asserted-by":"crossref","unstructured":"Gitler AD, Dhillon P, Shorter J (2017) Neurodegenerative disease: models, mechanisms, and a new hope. DMM Disease Models and Mechanisms, vol 10. Company of Biologists Ltd, pp 499\u2013502","DOI":"10.1242\/dmm.030205"},{"issue":"3","key":"4184_CR2","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.3390\/ijms23031851","volume":"23","author":"RNL Lamptey","year":"2022","unstructured":"Lamptey RNL, Chaulagain B, Trivedi R, Gothwal A, Layek B, Singh J (2022) A review of the Common Neurodegenerative disorders: current therapeutic approaches and the potential role of Nanotherapeutics. Int J Mol Sci 23(3):1851","journal-title":"Int J Mol Sci"},{"issue":"9","key":"4184_CR3","doi-asserted-by":"publisher","first-page":"2714","DOI":"10.1007\/s11064-023-03924-w","volume":"48","author":"N Siddiqui","year":"2023","unstructured":"Siddiqui N, Ali J, Parvez S, Najmi AK, Akhtar M (2023) Neuroprotective role of DPP-4 inhibitor linagliptin against neurodegeneration, Neuronal Insulin Resistance and Neuroinflammation Induced by Intracerebroventricular Streptozotocin in Rat Model of Alzheimer\u2019s Disease. Neurochem Res 48(9):2714\u20132730","journal-title":"Neurochem Res"},{"issue":"4","key":"4184_CR4","doi-asserted-by":"publisher","first-page":"3391","DOI":"10.3892\/mmr.2016.4948","volume":"13","author":"WW CHEN","year":"2016","unstructured":"CHEN WW, ZHANG X, HUANG WJ (2016) Role of neuroinflammation in neurodegenerative diseases (review). Mol Med Rep 13(4):3391\u20133396","journal-title":"Mol Med Rep"},{"key":"4184_CR5","doi-asserted-by":"crossref","unstructured":"Samarth RM, Samarth M, Matsumoto Y (2017) Medicinally important aromatic plants with radioprotective activity, vol 3. Future Science OA. Future Medicine Ltd.;","DOI":"10.4155\/fsoa-2017-0061"},{"issue":"11","key":"4184_CR6","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.3390\/cells10113041","volume":"10","author":"RJ Tuieng","year":"2021","unstructured":"Tuieng RJ, Cartmell SH, Kirwan CC, Sherratt MJ (2021) The effects of Ionising and Non-ionising Electromagnetic Radiation on Extracellular Matrix proteins. Cells 10(11):3041","journal-title":"Cells"},{"issue":"1","key":"4184_CR7","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1039\/c5tx00222b","volume":"5","author":"IV Mavragani","year":"2016","unstructured":"Mavragani IV, Laskaratou DA, Frey B, Cand\u00e9ias SM, Gaipl US, Lumniczky K et al (2016) Key mechanisms involved in ionizing radiation-induced systemic effects. A current review. Toxicol Res (Camb) 5(1):12\u201333","journal-title":"Toxicol Res (Camb)"},{"issue":"2","key":"4184_CR8","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1089\/ars.2013.5489","volume":"21","author":"JA Reisz","year":"2014","unstructured":"Reisz JA, Bansal N, Qian J, Zhao W, Furdui CM (2014) Effects of Ionizing Radiation on Biological molecules\u2014mechanisms of damage and emerging methods of detection. Antioxid Redox Signal 21(2):260\u2013292","journal-title":"Antioxid Redox Signal"},{"issue":"11","key":"4184_CR9","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.3390\/cancers15112999","volume":"15","author":"C R\u00fcbe","year":"2023","unstructured":"R\u00fcbe C, Raid S, Palm J, R\u00fcbe C (2023) Radiation-Induced Brain Injury: Age Dependency of Neurocognitive Dysfunction following Radiotherapy. Cancers (Basel) 15(11):2999","journal-title":"Cancers (Basel)"},{"key":"4184_CR10","doi-asserted-by":"crossref","unstructured":"Hu C, Zuo H, Li Y (2021) Effects of Radiofrequency Electromagnetic Radiation on neurotransmitters in the brain. Front Public Health. ;9","DOI":"10.3389\/fpubh.2021.691880"},{"key":"4184_CR11","doi-asserted-by":"crossref","unstructured":"Wang Q, Xie C, Xi S, Qian F, Peng X, Huang J et al (2020) Radioprotective effect of flavonoids on ionizing radiation-induced brain damage, vol 25. Molecules. MDPI AG","DOI":"10.3390\/molecules25235719"},{"key":"4184_CR12","doi-asserted-by":"crossref","unstructured":"Aly AA, Deris S, Bin, Zaki N (2008) Research review on the biological effect of cell phone radiation on human. In: 2008 International Conference on Innovations in Information Technology. IEEE; pp. 140\u20134","DOI":"10.1109\/INNOVATIONS.2008.4781774"},{"key":"4184_CR13","doi-asserted-by":"crossref","unstructured":"Dowlath MJH, Karuppannan SK, Sinha P, Dowlath NS, Arunachalam KD, Ravindran B et al (2021) Effects of radiation and role of plants in radioprotection: a critical review. Science of the Total Environment, vol 779. Elsevier B.V.","DOI":"10.1016\/j.scitotenv.2021.146431"},{"issue":"12","key":"4184_CR14","doi-asserted-by":"publisher","first-page":"1864","DOI":"10.2174\/092986712800099776","volume":"19","author":"D Marazziti","year":"2012","unstructured":"Marazziti D, Baroni S, Catena-Dell\u2019Osso M, Schiavi E, Ceresoli D, Conversano C et al (2012) Cognitive, Psychological and Psychiatric effects of Ionizing Radiation exposure. Curr Med Chem 19(12):1864\u20131869","journal-title":"Curr Med Chem"},{"issue":"4","key":"4184_CR15","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3390\/diagnostics9040127","volume":"9","author":"V Cuccurullo","year":"2019","unstructured":"Cuccurullo V, Di Stasio GD, Cascini GL, Gatta G, Bianco C (2019) The Molecular effects of Ionizing radiations on Brain cells: Radiation necrosis vs. Tumor Recurrence Diagnostics 9(4):127","journal-title":"Tumor Recurrence Diagnostics"},{"issue":"13","key":"4184_CR16","doi-asserted-by":"publisher","first-page":"5921","DOI":"10.1039\/D3FO00637A","volume":"14","author":"SV Raghu","year":"2023","unstructured":"Raghu SV, Kudva AK, Krishnamurthy RG, Mudgal J, George T, Baliga MS (2023) Neuroprotective effects of dietary plants and phytochemicals against radiation-induced cognitive and behavioral deficits: a comprehensive review of evidence and prospects for future research. Food Funct 14(13):5921\u20135935","journal-title":"Food Funct"},{"key":"4184_CR17","doi-asserted-by":"crossref","unstructured":"Narayanan SN, Jetti R, Kesari KK, Kumar RS, Nayak SB, Bhat PG (2019) Radiofrequency electromagnetic radiation-induced behavioral changes and their possible basis. Environmental Science and Pollution Research, vol 26. Springer, pp 30693\u201330710","DOI":"10.1007\/s11356-019-06278-5"},{"issue":"11","key":"4184_CR18","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1080\/09553002.2021.1969055","volume":"97","author":"H Hinrikus","year":"2021","unstructured":"Hinrikus H, Lass J, Bachmann M (2021) Threshold of radiofrequency electromagnetic field effect on human brain. Int J Radiat Biol 97(11):1505\u20131515","journal-title":"Int J Radiat Biol"},{"issue":"12","key":"4184_CR19","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1179\/1743132814Y.0000000392","volume":"36","author":"N Saikhedkar","year":"2014","unstructured":"Saikhedkar N, Bhatnagar M, Jain A, Sukhwal P, Sharma C, Jaiswal N (2014) Effects of mobile phone radiation (900\u00a0MHz radiofrequency) on structure and functions of rat brain. Neurol Res 36(12):1072\u20131079","journal-title":"Neurol Res"},{"key":"4184_CR20","doi-asserted-by":"publisher","first-page":"106972","DOI":"10.1016\/j.envint.2021.106972","volume":"159","author":"G Benke","year":"2022","unstructured":"Benke G, Abramson MJ, Zeleke BM, Kaufman J, Karipidis K, Kelsall H et al (2022) The effect of long-term radiofrequency exposure on cognition in human observational studies: a protocol for a systematic review. Environ Int 159:106972","journal-title":"Environ Int"},{"issue":"3","key":"4184_CR21","doi-asserted-by":"publisher","first-page":"265","DOI":"10.4062\/biomolther.2018.152","volume":"27","author":"JH Kim","year":"2019","unstructured":"Kim JH, Lee JK, Kim HG, Kim KB, Kim HR (2019) Possible effects of Radiofrequency Electromagnetic Field exposure on central nerve system. Biomol Ther (Seoul) 27(3):265\u2013275","journal-title":"Biomol Ther (Seoul)"},{"key":"4184_CR22","doi-asserted-by":"publisher","first-page":"113829","DOI":"10.1016\/j.jep.2021.113829","volume":"273","author":"S Ahmed","year":"2021","unstructured":"Ahmed S, Ding X, Sharma A (2021) Exploring scientific validation of Triphala Rasayana in ayurveda as a source of rejuvenation for contemporary healthcare: an update. J Ethnopharmacol 273:113829","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"4184_CR23","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3164\/jcbn.40.74","volume":"40","author":"GC Jagetia","year":"2007","unstructured":"Jagetia GC (2007) Radioprotective Potential of Plants and herbs against the effects of Ionizing Radiation. J Clin Biochem Nutr 40(2):74\u201381","journal-title":"J Clin Biochem Nutr"},{"key":"4184_CR24","doi-asserted-by":"crossref","unstructured":"Zhang X, Chen X, Wang L, He C, Shi Z, Fu Q et al (2021) Review of the Efficacy and Mechanisms of Traditional Chinese Medicines as a therapeutic option for Ionizing Radiation Induced damage. Frontiers in Pharmacology, vol 12. Frontiers Media S.A.","DOI":"10.3389\/fphar.2021.617559"},{"key":"4184_CR25","unstructured":"Exploring Natural Products as Radioprotective Agents for Cancer Therapy Mechanisms, Challenges, and Opportunities"},{"key":"4184_CR26","doi-asserted-by":"crossref","unstructured":"Zhang Y, Huang Y, Li Z, Wu H, Zou B, Xu Y (2023) Exploring Natural products as Radioprotective agents for Cancer Therapy: mechanisms, challenges, and opportunities. Cancers (Basel) 15(14):3585","DOI":"10.3390\/cancers15143585"},{"key":"4184_CR27","doi-asserted-by":"crossref","unstructured":"Puri V, Kanojia N, Sharma A, Huanbutta K, Dheer D, Sangnim T (2022) Natural product-based pharmacological studies for neurological disorders. Frontiers in Pharmacology, vol 13. Frontiers Media S.A.","DOI":"10.3389\/fphar.2022.1011740"},{"issue":"3","key":"4184_CR28","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.dcmed.2023.10.003","volume":"6","author":"G Rohilla","year":"2023","unstructured":"Rohilla G, Masand P, Dhama P, Anurag, Gupta S, Sharma A (2023) Quality by design approach for the investigation of critical characteristics of Phyllanthus emblica from different vicinities. Digit Chin Med 6(3):272\u2013284","journal-title":"Digit Chin Med"},{"issue":"4","key":"4184_CR29","doi-asserted-by":"publisher","first-page":"265","DOI":"10.3857\/roj.2018.00381","volume":"36","author":"V Kuruba","year":"2018","unstructured":"Kuruba V, Gollapalli P (2018) Natural radioprotectors and their impact on cancer drug discovery. Radiat Oncol J 36(4):265\u2013275","journal-title":"Radiat Oncol J"},{"key":"4184_CR30","doi-asserted-by":"crossref","unstructured":"Greene-Schloesser D, Robbins ME, Peiffer AM, Shaw EG, Wheeler KT, Chan MD (2012) Radiation-induced brain injury: a review. 2 JUL, Front Oncol","DOI":"10.3389\/fonc.2012.00073"},{"issue":"11","key":"4184_CR31","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3109\/09553002.2012.711504","volume":"88","author":"B Avci","year":"2012","unstructured":"Avci B, Akar A, Bilgici B, Tun\u00e7el \u00d6K (2012) Oxidative stress induced by 1.8 GHz radio frequency electromagnetic radiation and effects of garlic extract in rats. Int J Radiat Biol 88(11):799\u2013805","journal-title":"Int J Radiat Biol"},{"issue":"4","key":"4184_CR32","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1007\/s12247-020-09486-6","volume":"16","author":"A Sharma","year":"2021","unstructured":"Sharma A, Rejeeth C, Vivek R, Babu VN, Ding X (2021) Novel Green Silver Nanoparticles as Matrix in the detection of small molecules using matrix-assisted laser desorption ionization Mass Spectrometry (MALDI-MS). J Pharm Innov 16(4):715\u2013725","journal-title":"J Pharm Innov"},{"key":"4184_CR33","doi-asserted-by":"crossref","unstructured":"Peng XC, Huang JR, Wang SW, Liu L, Liu ZZ, Sethi G et al (2018) Traditional Chinese Medicine in Neuroprotection after Brain Insults with Special Reference to Radioprotection. Vol. Evidence-based Complementary and Alternative Medicine. Hindawi Limited; 2018","DOI":"10.1155\/2018\/2767208"},{"issue":"20","key":"4184_CR34","doi-asserted-by":"publisher","first-page":"3074","DOI":"10.2174\/1389557521666210120112814","volume":"21","author":"DK Lang","year":"2021","unstructured":"Lang DK, Singh H, Arora A, Arora R, Saini B, Arora S et al (2021) Radioprotectors: Nature\u2019s Boon. Mini-Reviews Med Chem 21(20):3074\u20133096","journal-title":"Mini-Reviews Med Chem"},{"key":"4184_CR35","doi-asserted-by":"crossref","unstructured":"Turnquist C, Harris BT, Harris CC (2020) Radiation-induced brain injury: current concepts and therapeutic strategies targeting neuroinflammation. Neurooncol Adv 2(1)","DOI":"10.1093\/noajnl\/vdaa057"},{"issue":"2","key":"4184_CR36","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4103\/jpbs.jpbs_502_21","volume":"14","author":"P Shivappa","year":"2022","unstructured":"Shivappa P, Bernhardt G (2022) Natural radioprotectors on current and future perspectives: a mini-review. J Pharm Bioallied Sci 14(2):57","journal-title":"J Pharm Bioallied Sci"},{"key":"4184_CR37","doi-asserted-by":"crossref","unstructured":"Greene-Schloesser D, Robbins ME, Peiffer AM, Shaw EG, Wheeler KT, Chan MD (2012) Radiation-induced brain injury: a review. Front Oncol 2","DOI":"10.3389\/fonc.2012.00073"},{"issue":"2","key":"4184_CR38","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0031-9422(97)00423-8","volume":"47","author":"T Fossen","year":"1998","unstructured":"Fossen T, Pedersen AT, Andersen \u00d8M (1998) Flavonoids from red onion (Allium cepa). Phytochemistry 47(2):281\u2013285","journal-title":"Phytochemistry"},{"issue":"4","key":"4184_CR39","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.jaim.2019.08.002","volume":"11","author":"S Kumar","year":"2020","unstructured":"Kumar S, Modgil S, Bammidi S, Minhas G, Shri R, Kaushik S et al (2020) Allium cepa exerts neuroprotective effect on retinal ganglion cells of pterygopalatine artery (PPA) ligated mice. J Ayurveda Integr Med 11(4):489\u2013494","journal-title":"J Ayurveda Integr Med"},{"issue":"9","key":"4184_CR40","doi-asserted-by":"publisher","first-page":"348","DOI":"10.3390\/antiox8090348","volume":"8","author":"S Jakaria Md, Azam","year":"2019","unstructured":"Jakaria Md, Azam S, Cho DY, Haque ME, Kim IS, Choi DK (2019) The methanol extract of Allium cepa L. protects inflammatory markers in LPS-Induced BV-2 microglial cells and upregulates the Antiapoptotic Gene and antioxidant enzymes in N27-A cells. Antioxidants 8(9):348","journal-title":"Antioxidants"},{"key":"4184_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuro.2015.04.007","volume":"49","author":"T Singh","year":"2015","unstructured":"Singh T, Goel RK (2015) Neuroprotective effect of Allium cepa L. in aluminium chloride induced neurotoxicity. Neurotoxicology 49:1\u20137","journal-title":"Neurotoxicology"},{"key":"4184_CR42","doi-asserted-by":"publisher","first-page":"108662","DOI":"10.1016\/j.neuropharm.2021.108662","volume":"195","author":"N Siddiqui","year":"2021","unstructured":"Siddiqui N, Ali J, Parvez S, Zameer S, Najmi AK, Akhtar M (2021) Linagliptin, a DPP-4 inhibitor, ameliorates A\u03b2 (1\u2009\u2013\u200942) peptides induced neurodegeneration and brain insulin resistance (BIR) via insulin receptor substrate-1 (IRS-1) in rat model of Alzheimer\u2019s disease. Neuropharmacology 195:108662","journal-title":"Neuropharmacology"},{"key":"4184_CR43","doi-asserted-by":"crossref","unstructured":"Kaur R, Randhawa K, Kaur S, Shri R (2020) Allium cepa fraction attenuates STZ-induced dementia via cholinesterase inhibition and amelioration of oxidative stress in mice. J Basic Clin Physiol Pharmacol. ;31(3)","DOI":"10.1515\/jbcpp-2019-0197"},{"key":"4184_CR44","doi-asserted-by":"crossref","unstructured":"Siddiqui N, Saifi A, Chaudhary A, Tripathi PN, Chaudhary A, Sharma A (2023) Multifaceted neuroprotective role of Punicalagin: a review. Neurochem Res","DOI":"10.1007\/s11064-023-04081-w"},{"key":"4184_CR45","doi-asserted-by":"crossref","unstructured":"Siddiqui N, Sharma A, Kesharwani A, Anurag, Parihar VK (2024) Exploring role of natural compounds in molecular alterations Associated with Brain Ageing: a perspective towards Nutrition for Ageing Brain. Ageing Res Rev. ;102282","DOI":"10.1016\/j.arr.2024.102282"},{"issue":"11","key":"4184_CR46","doi-asserted-by":"publisher","first-page":"4009","DOI":"10.1111\/1750-3841.15474","volume":"85","author":"V Singh","year":"2020","unstructured":"Singh V, Shri R, Krishan P, Singh IP, Shah P (2020) Isolation and characterization of components responsible for neuroprotective effects of Allium cepa outer scale extract against ischemia reperfusion induced cerebral injury in mice. J Food Sci 85(11):4009\u20134017","journal-title":"J Food Sci"},{"key":"4184_CR47","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.foodres.2015.05.038","volume":"75","author":"SK Park","year":"2015","unstructured":"Park SK, Jin DE, Park CH, Seung TW, Guo TJ, Song JW et al (2015) Ameliorating effects of ethyl acetate fraction from onion (Allium cepa L.) flesh and peel in mice following trimethyltin-induced learning and memory impairment. Food Res Int 75:53\u201360","journal-title":"Food Res Int"},{"issue":"1","key":"4184_CR48","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3390\/biom10010059","volume":"10","author":"H Khan","year":"2019","unstructured":"Khan H, Ullah H, Aschner M, Cheang WS, Akkol EK (2019) Neuroprotective effects of Quercetin in Alzheimer\u2019s Disease. Biomolecules 10(1):59","journal-title":"Biomolecules"},{"key":"4184_CR49","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.neuint.2017.03.006","volume":"108","author":"KH Reeta","year":"2017","unstructured":"Reeta KH, Singh D, Gupta YK (2017) Chronic treatment with taurine after intracerebroventricular streptozotocin injection improves cognitive dysfunction in rats by modulating oxidative stress, cholinergic functions and neuroinflammation. Neurochem Int 108:146\u2013156","journal-title":"Neurochem Int"},{"issue":"2","key":"4184_CR50","doi-asserted-by":"publisher","first-page":"153","DOI":"10.5114\/bta.2022.116210","volume":"103","author":"E Hegazy","year":"2022","unstructured":"Hegazy E, Sabry A, Khalil WKB (2022) Neuroprotective effects of onion and garlic root extracts against Alzheimer\u2019s disease in rats: antimicrobial, histopathological, and molecular studies. BioTechnologia 103(2):153\u2013167","journal-title":"BioTechnologia"},{"issue":"sup1","key":"4184_CR51","doi-asserted-by":"publisher","first-page":"S39","DOI":"10.1080\/10408398.2018.1499074","volume":"59","author":"JD Teshika","year":"2019","unstructured":"Teshika JD, Zakariyyah AM, Zaynab T, Zengin G, Rengasamy KR, Pandian SK et al (2019) Traditional and modern uses of onion bulb (Allium cepa L.): a systematic review. Crit Rev Food Sci Nutr 59(sup1):S39\u201370","journal-title":"Crit Rev Food Sci Nutr"},{"key":"4184_CR52","doi-asserted-by":"crossref","unstructured":"Lee BK, Jung YS (2016) Allium cepa Extract and Quercetin Protect Neuronal Cells from Oxidative Stress via PKC- \u03f5 Inactivation\/ERK1\/2 Activation. Oxid Med Cell Longev. ;2016","DOI":"10.1155\/2016\/2495624"},{"issue":"1","key":"4184_CR53","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1080\/13880209.2021.1874028","volume":"59","author":"N Marefati","year":"2021","unstructured":"Marefati N, Ghorani V, Shakeri F, Boskabady M, Kianian F, Rezaee R et al (2021) A review of anti-inflammatory, antioxidant, and immunomodulatory effects of Allium cepa and its main constituents. Pharm Biol 59(1):285\u2013300","journal-title":"Pharm Biol"},{"key":"4184_CR54","doi-asserted-by":"crossref","unstructured":"Nayak S, Nayanatara AK, Hegde A, Kini D, Blossom R, Poojary V (2021) R. Neuroprotective role of Allium cepa and Allium sativum on Hippocampus, striatum and cerebral cortex in Wistar rats. Res J Pharm Technol. ;2406\u20132411","DOI":"10.52711\/0974-360X.2021.00424"},{"issue":"1","key":"4184_CR55","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3390\/molecules28010417","volume":"28","author":"R Jadhav","year":"2023","unstructured":"Jadhav R, Kulkarni YA (2023) Neuroprotective effect of Quercetin and Memantine against AlCl3-Induced neurotoxicity in albino Wistar rats. Molecules 28(1):417","journal-title":"Molecules"},{"key":"4184_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/2495624","volume":"2016","author":"BK Lee","year":"2016","unstructured":"Lee BK, Jung YS (2016) Allium cepa Extract and Quercetin protect neuronal cells from oxidative stress via PKC- \u03b5 Inactivation\/ERK1\/2 activation. Oxid Med Cell Longev 2016:1\u20139","journal-title":"Oxid Med Cell Longev"},{"issue":"3","key":"4184_CR57","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.bbrc.2004.05.217","volume":"320","author":"YS Jung","year":"2004","unstructured":"Jung YS, Ryu BR, Lee BK, Mook-Jung I, Kim SU, Lee SH et al (2004) Role for PKC-\u03b5 in neuronal death induced by oxidative stress. Biochem Biophys Res Commun 320(3):789\u2013794","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"4184_CR58","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.nut.2012.02.017","volume":"29","author":"SW Hyun","year":"2013","unstructured":"Hyun SW, Jang M, Park SW, Kim EJ, Jung YS (2013) Onion (Allium cepa) extract attenuates brain edema. Nutrition 29(1):244\u2013249","journal-title":"Nutrition"},{"issue":"3","key":"4184_CR59","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.3390\/ijms24031869","volume":"24","author":"FL Andronie-Cioara","year":"2023","unstructured":"Andronie-Cioara FL, Ardelean AI, Nistor-Cseppento CD, Jurcau A, Jurcau MC, Pascalau N et al (2023) Molecular mechanisms of Neuroinflammation in Aging and Alzheimer\u2019s Disease Progression. Int J Mol Sci 24(3):1869","journal-title":"Int J Mol Sci"},{"issue":"2","key":"4184_CR60","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/0304-3940(92)90033-4","volume":"136","author":"J Molina","year":"1992","unstructured":"Molina J, Jim\u00e9nez-Jim\u00e9nez FJ, Fernandez-Calle P, Lalinde L, Tenias J, Pondal M et al (1992) Serum lipid peroxides in patients with Parkinson\u2019s disease. Neurosci Lett 136(2):137\u2013140","journal-title":"Neurosci Lett"},{"issue":"1","key":"4184_CR61","first-page":"25","volume":"31","author":"M Salami","year":"2020","unstructured":"Salami M, Tamtaji OR, Mohammadifar M, Talaei SA, Tameh AA, Abed AR et al (2020) Neuroprotective effects of onion (Allium cepa) ethanolic extract on animal model of Parkinson\u2019s Disease Induced by 6-hydroxydopamine: a behavioral, biochemical, and histological study. Gazi Med J 31(1):25\u201329","journal-title":"Gazi Med J"},{"issue":"15","key":"4184_CR62","doi-asserted-by":"publisher","first-page":"7116","DOI":"10.3390\/app11157116","volume":"11","author":"S Silvestro","year":"2021","unstructured":"Silvestro S, Bramanti P, Mazzon E (2021) Role of Quercetin in Depressive-Like behaviors: findings from animal models. Appl Sci 11(15):7116","journal-title":"Appl Sci"},{"issue":"1","key":"4184_CR63","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s11011-017-0159-1","volume":"33","author":"N Samad","year":"2018","unstructured":"Samad N, Saleem A (2018) Administration of Allium cepa L. bulb attenuates stress-produced anxiety and depression and improves memory in male mice. Metab Brain Dis 33(1):271\u2013281","journal-title":"Metab Brain Dis"},{"issue":"1","key":"4184_CR64","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1080\/1028415X.2019.1587247","volume":"24","author":"V Singh","year":"2021","unstructured":"Singh V, Chauhan G, Shri R (2021) Anti-depressant like effects of quercetin 4\u2019-O-glucoside from Allium cepa via regulation of brain oxidative stress and monoamine levels in mice subjected to unpredictable chronic mild stress. Nutr Neurosci 24(1):35\u201344","journal-title":"Nutr Neurosci"},{"issue":"1","key":"4184_CR65","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1271\/bbb.70454","volume":"72","author":"H SAKAKIBARA","year":"2008","unstructured":"SAKAKIBARA H, YOSHINO S, KAWAI Y (2008) Antidepressant-like Effect of Onion (Allium cepa L.) Powder in a rat behavioral model of Depression. Biosci Biotechnol Biochem 72(1):94\u2013100","journal-title":"Biosci Biotechnol Biochem"},{"key":"4184_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2015\/103416","volume":"2015","author":"S Tasnim","year":"2015","unstructured":"Tasnim S, Haque PS, Bari MS, Hossain MM, Islam SMA, Shahriar M et al (2015) Allium sativum L. improves visual memory and attention in healthy human volunteers. Evidence-Based Complement Altern Med 2015:1\u20138","journal-title":"Evidence-Based Complement Altern Med"},{"issue":"1","key":"4184_CR67","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3390\/nu9010024","volume":"9","author":"N Nillert","year":"2017","unstructured":"Nillert N, Pannangrong W, Welbat J, Chaijaroonkhanarak W, Sripanidkulchai K, Sripanidkulchai B (2017) Neuroprotective effects of aged Garlic Extract on Cognitive Dysfunction and Neuroinflammation Induced by \u03b2-Amyloid in rats. Nutrients 9(1):24","journal-title":"Nutrients"},{"key":"4184_CR68","unstructured":"Saini N, Kadian M, Khera A, Aggarwal A, Kumar A (2021) Therapeutic potential of Allium Sativum against the A\u03b2 (1\u201340)-induced oxidative stress and mitochondrial dysfunction in the Wistar rats [Internet]. Vol. 10, Am J Neurodegener Dis. Available from: www.AJND.us\/"},{"issue":"3","key":"4184_CR69","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s12640-016-9625-5","volume":"30","author":"A Manral","year":"2016","unstructured":"Manral A, Meena P, Saini V, Siraj F, Shalini S, Tiwari M (2016) DADS analogues ameliorated the cognitive impairments of Alzheimer-Like Rat Model Induced by Scopolamine. Neurotox Res 30(3):407\u2013426","journal-title":"Neurotox Res"},{"issue":"1","key":"4184_CR70","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3390\/antiox11010087","volume":"11","author":"MS Nadeem","year":"2021","unstructured":"Nadeem MS, Kazmi I, Ullah I, Muhammad K, Anwar F (2021) Allicin, an antioxidant and neuroprotective Agent, ameliorates cognitive impairment. Antioxidants 11(1):87","journal-title":"Antioxidants"},{"issue":"1","key":"4184_CR71","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1080\/J157v03n01_05","volume":"3","author":"N Chauhan","year":"2003","unstructured":"Chauhan N (2003) Anti-amyloidogenic effect of Allium sativum in Alzheimer\u2019s transgenic model Tg2576. J Herb Pharmacother 3(1):95\u2013107","journal-title":"J Herb Pharmacother"},{"issue":"13","key":"4184_CR72","doi-asserted-by":"publisher","first-page":"6950","DOI":"10.3390\/ijms23136950","volume":"23","author":"P Tedeschi","year":"2022","unstructured":"Tedeschi P, Nigro M, Travagli A, Catani M, Cavazzini A, Merighi S et al (2022) Therapeutic potential of Allicin and aged Garlic Extract in Alzheimer\u2019s Disease. Int J Mol Sci 23(13):6950","journal-title":"Int J Mol Sci"},{"issue":"4","key":"4184_CR73","doi-asserted-by":"publisher","first-page":"444","DOI":"10.4103\/0253-7613.161274","volume":"47","author":"S Kumar","year":"2015","unstructured":"Kumar S (2015) Dual inhibition of acetylcholinesterase and butyrylcholinesterase enzymes by allicin. Indian J Pharmacol 47(4):444","journal-title":"Indian J Pharmacol"},{"key":"4184_CR74","doi-asserted-by":"publisher","unstructured":"Bigham M, Mohammadipour A, Hosseini M, Amir, Malvandi M, Ebrahimzadeh-Bideskan A Neuroprotective effects of garlic extract on dopaminergic neurons of substantia nigra in a rat model of Parkinson\u2019s disease: motor and non-motor outcomes. https:\/\/doi.org\/10.1007\/s11011-021-00705-8","DOI":"10.1007\/s11011-021-00705-8"},{"key":"4184_CR75","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.ejphar.2016.11.033","volume":"794","author":"T Baluchnejadmojarad","year":"2017","unstructured":"Baluchnejadmojarad T, Kiasalari Z, Afshin-Majd S, Ghasemi Z, Roghani M (2017) S-allyl cysteine ameliorates cognitive deficits in streptozotocin-diabetic rats via suppression of oxidative stress, inflammation, and acetylcholinesterase. Eur J Pharmacol 794:69\u201376","journal-title":"Eur J Pharmacol"},{"issue":"17","key":"4184_CR76","doi-asserted-by":"publisher","first-page":"13386","DOI":"10.3390\/ijms241713386","volume":"24","author":"YA Munni","year":"2023","unstructured":"Munni YA, Dash R, Choi HJ, Mitra S, Hannan MA, Mazumder K et al (2023) Differential effects of the processed and unprocessed garlic (Allium sativum L.) ethanol extracts on Neuritogenesis and synaptogenesis in rat primary hippocampal neurons. Int J Mol Sci 24(17):13386","journal-title":"Int J Mol Sci"},{"issue":"3","key":"4184_CR77","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1159\/000430271","volume":"36","author":"H Liu","year":"2015","unstructured":"Liu H, Mao P, Wang J, Wang T, Xie CH (2015) Allicin protects PC12 cells against 6-OHDA-Induced oxidative stress and mitochondrial dysfunction via regulating mitochondrial dynamics. Cell Physiol Biochem 36(3):966\u2013979","journal-title":"Cell Physiol Biochem"},{"issue":"4","key":"4184_CR78","doi-asserted-by":"publisher","first-page":"175","DOI":"10.4103\/0253-7613.43165","volume":"40","author":"D Dhingra","year":"2008","unstructured":"Dhingra D, Kumar V (2008) Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice. Indian J Pharmacol 40(4):175","journal-title":"Indian J Pharmacol"},{"issue":"3","key":"4184_CR79","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1159\/000430271","volume":"36","author":"H Liu","year":"2015","unstructured":"Liu H, Mao P, Wang J, Wang T, Xie CH (2015) Allicin protects PC12 cells against 6-OHDA-Induced oxidative stress a and mitochondrial dysfunction via regulating mitochondrial dynamics. Cell Physiol Biochem 36(3):966\u2013979","journal-title":"Cell Physiol Biochem"},{"issue":"8","key":"4184_CR80","doi-asserted-by":"publisher","first-page":"2677","DOI":"10.1007\/s11011-022-01021-5","volume":"37","author":"A Asemi-Rad","year":"2022","unstructured":"Asemi-Rad A, Moafi M, Aliaghaei A, Abbaszadeh HA, Abdollahifar MA, Ebrahimi MJ et al (2022) The effect of dopaminergic neuron transplantation and melatonin co-administration on oxidative stress-induced cell death in Parkinson\u2019s disease. Metab Brain Dis 37(8):2677\u20132685","journal-title":"Metab Brain Dis"},{"issue":"6","key":"4184_CR81","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1056\/NEJM198808113190606","volume":"319","author":"PW Gold","year":"1988","unstructured":"Gold PW, Goodwin FK, Chrousos GP (1988) Clinical and biochemical manifestations of Depression. N Engl J Med 319(6):348\u2013353","journal-title":"N Engl J Med"},{"issue":"3","key":"4184_CR82","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0944-7113(96)80043-2","volume":"2","author":"T Grune","year":"1996","unstructured":"Grune T, Scherat T, Behrend H, Conradi E, Brenke R, Siems W (1996) Influence of Allium sativum on oxidative stress status \u2014 a clinical investigation. Phytomedicine 2(3):205\u2013207","journal-title":"Phytomedicine"},{"key":"4184_CR83","doi-asserted-by":"crossref","unstructured":"Ncir M, Saoudi M, Sellami H, Rahmouni F, Lahyani A, Makni Ayadi F et al (2018) In vitro and in vivo studies of Allium sativum extract against deltamethrin-induced oxidative stress in rats brain and kidney. Arch Physiol Biochem. ;124(3):207\u201317","DOI":"10.1080\/13813455.2017.1376335"},{"key":"4184_CR84","doi-asserted-by":"publisher","first-page":"100323","DOI":"10.1016\/j.prmcm.2023.100323","volume":"9","author":"AN Jikah","year":"2023","unstructured":"Jikah AN, Edo GI (2023) Mechanisms of action by sulphur compounds in Allium sativum. A review. Pharmacol Res - Mod Chin Med 9:100323","journal-title":"Pharmacol Res - Mod Chin Med"},{"issue":"3","key":"4184_CR85","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s12017-016-8410-1","volume":"18","author":"Z Qu","year":"2016","unstructured":"Qu Z, Mossine VV, Cui J, Sun GY, Gu Z (2016) Protective effects of AGE and its components on Neuroinflammation and Neurodegeneration. Neuromolecular Med 18(3):474\u2013482","journal-title":"Neuromolecular Med"},{"key":"4184_CR86","doi-asserted-by":"publisher","first-page":"115174","DOI":"10.1016\/j.jep.2022.115174","volume":"292","author":"A Farid","year":"2022","unstructured":"Farid A, Yousry M, Safwat G (2022) Garlic (Allium sativum Linnaeus) improved inflammation and reduced cryptosporidiosis burden in immunocompromised mice. J Ethnopharmacol 292:115174","journal-title":"J Ethnopharmacol"},{"issue":"7","key":"4184_CR87","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1211\/jpp\/61.07.0014","volume":"61","author":"J Joy","year":"2009","unstructured":"Joy J, Nair CKK (2009) Protection of DNA and membranes from gamma-radiation induced damages by <\u2009I\u2009>\u2009Centella asiatica. J Pharm Pharmacol 61(7):941\u2013947","journal-title":"J Pharm Pharmacol"},{"issue":"4","key":"4184_CR88","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.3390\/nu12041028","volume":"12","author":"S Hazzaa","year":"2020","unstructured":"Hazzaa S, Abdelaziz S, Abd Eldaim M, Abdel-Daim M, Elgarawany G (2020) Neuroprotective potential of Allium sativum against Monosodium Glutamate-Induced Excitotoxicity: impact on short-term memory, Gliosis, and oxidative stress. Nutrients 12(4):1028","journal-title":"Nutrients"},{"key":"4184_CR89","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1002\/alz.064289","volume":"19","author":"AB Speers","year":"2023","unstructured":"Speers AB, Brandes MS, Kedjejian NE, Matthews DG, Caruso M, Wright KM et al (2023) Investigating the effects of centella asiatica on neuroinflammation in beta-amyloid overexpressing mice. Alzheimer\u2019s Dement 19:S7","journal-title":"Alzheimer\u2019s Dement"},{"key":"4184_CR90","doi-asserted-by":"crossref","unstructured":"Speers AB, Garc\u00eda-Jaramillo M, Feryn A, Matthews DG, Lichtenberg T, Caruso M et al (2021) Centella asiatica alters metabolic pathways Associated with Alzheimer\u2019s Disease in the 5xFAD mouse model of \u00df-Amyloid Accumulation. Front Pharmacol. ;12","DOI":"10.3389\/fphar.2021.788312"},{"issue":"4","key":"4184_CR91","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.jtcme.2015.07.002","volume":"6","author":"CL Chen","year":"2016","unstructured":"Chen CL, Tsai WH, Chen CJ, Pan TM (2016) Centella asiatica extract protects against amyloid \u03b21\u201340-induced neurotoxicity in neuronal cells by activating the antioxidative defence system. J Tradit Complement Med 6(4):362\u2013369","journal-title":"J Tradit Complement Med"},{"key":"4184_CR92","doi-asserted-by":"crossref","unstructured":"Bertollo AG, Mingoti MED, de Medeiros J, da Silva GB, Capoani GT, Lindemann H et al (2024) Hydroalcoholic Extract of Centella asiatica and Madecassic Acid Reverse Depressive-Like behaviors, inflammation and oxidative stress in adult rats submitted to stress in early life. Mol Neurobiol","DOI":"10.1007\/s12035-024-04198-1"},{"issue":"1","key":"4184_CR93","doi-asserted-by":"publisher","first-page":"41","DOI":"10.2131\/jts.35.41","volume":"35","author":"N Haleagrahara","year":"2010","unstructured":"Haleagrahara N, Ponnusamy K (2010) Neuroprotective effect of Centella asiatica extract (CAE) on experimentally induced parkinsonism in aged Sprague-Dawley rats. J Toxicol Sci 35(1):41\u201347","journal-title":"J Toxicol Sci"},{"key":"4184_CR94","doi-asserted-by":"crossref","unstructured":"Wong JH, Barron AM, Abdullah JM (2021) Mitoprotective effects of Centella asiatica (L.) Urb.: anti-inflammatory and neuroprotective opportunities in neurodegenerative disease. Front Pharmacol. ;12","DOI":"10.3389\/fphar.2021.687935"},{"issue":"11","key":"4184_CR95","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1016\/j.apjtb.2015.07.024","volume":"5","author":"H Khotimah","year":"2015","unstructured":"Khotimah H, Ali M, Sumitro SB, Widodo MA (2015) Decreasing \u03b1-synuclein aggregation by methanolic extract of Centella asiatica in zebrafish Parkinson\u2019s model. Asian Pac J Trop Biomed 5(11):948\u2013954","journal-title":"Asian Pac J Trop Biomed"},{"key":"4184_CR96","first-page":"1","volume":"2012","author":"IE Orhan","year":"2012","unstructured":"Orhan IE (2012) Centella asiatica (L.) Urban: from Traditional Medicine to Modern Medicine with neuroprotective potential. Evidence-Based Complement Altern Med 2012:1\u20138","journal-title":"Evidence-Based Complement Altern Med"},{"issue":"8","key":"4184_CR97","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.3390\/ijms20081871","volume":"20","author":"SM Chiroma","year":"2019","unstructured":"Chiroma SM, Baharuldin MTH, Mat Taib CN, Amom Z, Jagadeesan S, Ilham Adenan M et al (2019) Centella asiatica protects d-Galactose\/AlCl3 mediated Alzheimer\u2019s Disease-Like rats via PP2A\/GSK-3\u03b2 signaling pathway in their Hippocampus. Int J Mol Sci 20(8):1871","journal-title":"Int J Mol Sci"},{"key":"4184_CR98","doi-asserted-by":"crossref","unstructured":"Zakaria F, Akhtar MT, Wan Norhamidah WI, Noraini AB, Muhamad A, Shohaimi S et al (2023) Centella asiatica (L.) Urb. Extract ameliorates branched-chain amino acid (BCAA) metabolism in acute reserpine-induced stress zebrafish model via 1H Nuclear Magnetic Resonance (NMR)-based metabolomics approach. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. ;264:109501","DOI":"10.1016\/j.cbpc.2022.109501"},{"key":"4184_CR99","doi-asserted-by":"crossref","unstructured":"Sun B, Wu L, Wu Y, Zhang C, Qin L, Hayashi M et al (2020) Therapeutic potential of Centella asiatica and its triterpenes: a review. Front Pharmacol. ;11","DOI":"10.3389\/fphar.2020.568032"},{"key":"4184_CR100","doi-asserted-by":"crossref","unstructured":"Chandrika UG, Prasad Kumara PAAS (2015) Gotu Kola (Centella asiatica): Nutritional properties and Plausible Health benefits. Advances in Food and Nutrition Research. Academic Press Inc., pp 125\u2013157","DOI":"10.1016\/bs.afnr.2015.08.001"},{"key":"4184_CR101","doi-asserted-by":"crossref","unstructured":"Gray NE, Zweig JA, Matthews DG, Caruso M, Quinn JF, Soumyanath A (2017) Centella asiatica Attenuates Mitochondrial Dysfunction and Oxidative Stress in A\u03b2-Exposed Hippocampal Neurons. Oxid Med Cell Longev. ;2017","DOI":"10.1155\/2017\/7023091"},{"issue":"4","key":"4184_CR102","doi-asserted-by":"publisher","first-page":"892","DOI":"10.3390\/molecules25040892","volume":"25","author":"ZZ Hafiz","year":"2020","unstructured":"Hafiz ZZ, Amin M, \u2018Afif M, Johari James RM, Teh LK, Salleh MZ, Adenan MI (2020) Inhibitory effects of Raw-Extract Centella asiatica (RECA) on acetylcholinesterase, inflammations, and oxidative stress activities via in Vitro and in vivo. Molecules 25(4):892","journal-title":"Molecules"},{"issue":"4","key":"4184_CR103","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1002\/ptr.5582","volume":"30","author":"P Chanana","year":"2016","unstructured":"Chanana P, Kumar A (2016) Possible involvement of nitric Oxide Modulatory mechanisms in the neuroprotective effect of Centella asiatica against Sleep Deprivation Induced anxiety like Behaviour, oxidative damage and neuroinflammation. Phytother Res 30(4):671\u2013680","journal-title":"Phytother Res"},{"issue":"6","key":"4184_CR104","doi-asserted-by":"publisher","first-page":"3233","DOI":"10.15419\/bmrat.v6i6.550","volume":"6","author":"S Jagadeesan","year":"2019","unstructured":"Jagadeesan S, Musa Chiroma S, Baharuldin MTH, Taib CNM, Amom Z, Adenan MI et al (2019) Centella asiatica prevents chronic unpredictable mild stress-induced behavioral changes in rats. Biomedical Res Therapy 6(6):3233\u20133243","journal-title":"Biomedical Res Therapy"},{"issue":"3","key":"4184_CR105","doi-asserted-by":"publisher","first-page":"933","DOI":"10.3233\/JAD-142217","volume":"45","author":"NE Gray","year":"2015","unstructured":"Gray NE, Sampath H, Zweig JA, Quinn JF, Soumyanath A (2015) Centella asiatica attenuates Amyloid-\u03b2-Induced oxidative stress and mitochondrial dysfunction. J Alzheimer\u2019s Disease 45(3):933\u2013946","journal-title":"J Alzheimer\u2019s Disease"},{"key":"4184_CR106","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.biopha.2018.08.010","volume":"107","author":"K Madhu","year":"2018","unstructured":"Madhu K (2018) Asiaticoside counteracts the in vitro activation of microglia and astrocytes: Innuendo for multiple sclerosis. Biomed Pharmacother 107:303\u2013305","journal-title":"Biomed Pharmacother"},{"key":"4184_CR107","doi-asserted-by":"crossref","unstructured":"Md Pisar M, Chee BJ, Long I, Osman A (2023) Protective effects of Centella asiatica extract on spatial memory and learning deficits in animal model of systemic inflammation induced by lipopolysaccharide. Ann Med. ;55(1)","DOI":"10.1080\/07853890.2023.2224970"},{"key":"4184_CR108","unstructured":"Hosseini M, Boskabady MH, Khazdair MR (2021) Neuroprotective effects of coriandrum sativum and its constituent, linalool: a review. Avicenna Journal of Phytomedicine, vol 11. Mashhad University of Medical Sciences, pp 436\u2013450"},{"key":"4184_CR109","doi-asserted-by":"crossref","unstructured":"Caputo L, Piccialli I, Ciccone R, de Caprariis P, Massa A, De Feo V et al (2021) Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-\u03b2 neurotoxicity. Phytother Res 35(1):486\u2013493","DOI":"10.1002\/ptr.6827"},{"key":"4184_CR110","first-page":"835","volume":"20","author":"Mptp-induced behavioral","year":"2021","unstructured":"Mptp-induced behavioral (2021) And oxidative changes in parkinson\u2019s disease mouse model. EXCLI J 20:835\u2013850","journal-title":"EXCLI J"},{"key":"4184_CR111","doi-asserted-by":"publisher","first-page":"116165","DOI":"10.1016\/j.jep.2023.116165","volume":"306","author":"YA Munni","year":"2023","unstructured":"Munni YA, Dash R, Mitra S, Dash N, Shima M, Moon IS (2023) Mechanistic study of Coriandrum sativum on neuritogenesis and synaptogenesis based on computationally guided in vitro analyses. J Ethnopharmacol 306:116165","journal-title":"J Ethnopharmacol"},{"key":"4184_CR112","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/j.biopha.2018.04.196","volume":"103","author":"AF Begnami","year":"2018","unstructured":"Begnami AF, Spindola HM, Ruiz ALTG, de Carvalho JE, Groppo FC, Rehder VLG (2018) Antinociceptive and anti-edema properties of the ethyl acetate fraction obtained from extracts of Coriandrum sativum Linn. Leaves. Biomed Pharmacother 103:1617\u20131622","journal-title":"Biomed Pharmacother"},{"key":"4184_CR113","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.physbeh.2013.08.006","volume":"120","author":"O Cioanca","year":"2013","unstructured":"Cioanca O, Hritcu L, Mihasan M, Hancianu M (2013) Cognitive-enhancing and antioxidant activities of inhaled coriander volatile oil in amyloid \u03b2(1\u201342) rat model of Alzheimer\u2019s disease. Physiol Behav 120:193\u2013202","journal-title":"Physiol Behav"},{"issue":"14","key":"4184_CR114","doi-asserted-by":"publisher","first-page":"5314","DOI":"10.3390\/molecules28145314","volume":"28","author":"A Santib\u00e1\u00f1ez","year":"2023","unstructured":"Santib\u00e1\u00f1ez A, Jim\u00e9nez-Ferrer E, Angulo-Bejarano PI, Sharma A, Herrera-Ruiz M (2023) Coriandrum sativum and its utility in Psychiatric disorders. Molecules 28(14):5314","journal-title":"Molecules"},{"issue":"6","key":"4184_CR115","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","volume":"5","author":"LM de Lau","year":"2006","unstructured":"de Lau LM, Breteler MM (2006) Epidemiology of Parkinson\u2019s disease. Lancet Neurol 5(6):525\u2013535","journal-title":"Lancet Neurol"},{"issue":"1","key":"4184_CR116","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/nprot.2006.342","volume":"2","author":"V Jackson-Lewis","year":"2007","unstructured":"Jackson-Lewis V, Przedborski S (2007) Protocol for the MPTP mouse model of Parkinson\u2019s disease. Nat Protoc 2(1):141\u2013151","journal-title":"Nat Protoc"},{"issue":"3","key":"4184_CR117","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s11130-022-00999-8","volume":"77","author":"N Saeki","year":"2022","unstructured":"Saeki N, Tamano H, Takeuchi A, Katahira M, Nishio R, Tamura H et al (2022) Heated Leaf Extract of Coriandrum sativum L. protects Nigral Dopaminergic Degeneration in rats. Plant Foods Hum Nutr 77(3):455\u2013459","journal-title":"Plant Foods Hum Nutr"},{"key":"4184_CR118","doi-asserted-by":"publisher","first-page":"103884","DOI":"10.1016\/j.jff.2020.103884","volume":"68","author":"S Sahoo","year":"2020","unstructured":"Sahoo S, Brijesh S (2020) Anxiolytic activity of Coriandrum sativum seeds aqueous extract on chronic restraint stressed mice and effect on brain neurotransmitters. J Funct Foods 68:103884","journal-title":"J Funct Foods"},{"issue":"5","key":"4184_CR119","first-page":"376","volume":"5","author":"MR Khazdair","year":"2015","unstructured":"Khazdair MR, Boskabady MH, Hosseini M, Rezaee R, M Tsatsakis A (2015) The effects of Crocus sativus (saffron) and its constituents on nervous system: a review. Avicenna J Phytomed 5(5):376\u2013391","journal-title":"Avicenna J Phytomed"},{"key":"4184_CR120","doi-asserted-by":"crossref","unstructured":"Koppula S, Choi C (2012) Anti-stress and Anti-amnesic effects of Coriandrum sativum Linn (Umbelliferae) extract \u2013 an experimental study in rats. Trop J Pharm Res. ;11(1)","DOI":"10.4314\/tjpr.v11i1.5"},{"issue":"8","key":"4184_CR121","doi-asserted-by":"publisher","first-page":"9572","DOI":"10.1021\/acsomega.8b00841","volume":"3","author":"SS Bharate","year":"2018","unstructured":"Bharate SS, Kumar V, Singh G, Singh A, Gupta M, Singh D et al (2018) Preclinical Development of Crocus sativus -based Botanical lead IIIM-141 for Alzheimer\u2019s Disease: Chemical standardization, efficacy, Formulation Development, Pharmacokinetics, and Safety Pharmacology. ACS Omega 3(8):9572\u20139585","journal-title":"ACS Omega"},{"issue":"3","key":"4184_CR122","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.jep.2004.06.022","volume":"96","author":"M Emamghoreishi","year":"2005","unstructured":"Emamghoreishi M, Khasaki M, Aazam MF (2005) Coriandrum sativum: evaluation of its anxiolytic effect in the elevated plus-maze. J Ethnopharmacol 96(3):365\u2013370","journal-title":"J Ethnopharmacol"},{"key":"4184_CR123","doi-asserted-by":"crossref","unstructured":"Bian Y, Zhao C, Lee SMY (2020) Neuroprotective Potency of Saffron Against Neuropsychiatric Diseases, neurodegenerative diseases, and other Brain disorders: from bench to Bedside. Front Pharmacol. ;11","DOI":"10.3389\/fphar.2020.579052"},{"issue":"1","key":"4184_CR124","doi-asserted-by":"publisher","first-page":"18150","DOI":"10.1038\/s41598-020-74770-x","volume":"10","author":"NS Koulakiotis","year":"2020","unstructured":"Koulakiotis NS, Purhonen P, Gikas E, Hebert H, Tsarbopoulos A (2020) Crocus-derived compounds alter the aggregation pathway of Alzheimer\u2019s Disease - associated beta amyloid protein. Sci Rep 10(1):18150","journal-title":"Sci Rep"},{"key":"4184_CR125","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.biopha.2017.12.090","volume":"98","author":"SI Bukhari","year":"2018","unstructured":"Bukhari SI, Manzoor M, Dhar MK (2018) A comprehensive review of the pharmacological potential of Crocus sativus and its bioactive apocarotenoids. Biomed Pharmacother 98:733\u2013745","journal-title":"Biomed Pharmacother"},{"key":"4184_CR126","doi-asserted-by":"crossref","unstructured":"Chalatsa I, Arvanitis DA, Koulakiotis NS, Giagini A, Skaltsounis AL, Papadopoulou-Daifoti Z et al (2019) The Crocus sativus compounds trans-crocin 4 and trans-crocetin modulate the amyloidogenic pathway and tau misprocessing in Alzheimer Disease neuronal cell culture models. Front Neurosci. ;13","DOI":"10.3389\/fnins.2019.00249"},{"issue":"4","key":"4184_CR127","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.pbb.2005.06.007","volume":"81","author":"AS Ahmad","year":"2005","unstructured":"Ahmad AS, Ansari MA, Ahmad M, Saleem S, Yousuf S, Hoda MN et al (2005) Neuroprotection by crocetin in a hemi-parkinsonian rat model. Pharmacol Biochem Behav 81(4):805\u2013813","journal-title":"Pharmacol Biochem Behav"},{"issue":"4","key":"4184_CR128","doi-asserted-by":"publisher","first-page":"377","DOI":"10.2174\/1570159X16666180321095705","volume":"17","author":"K Hatziagapiou","year":"2019","unstructured":"Hatziagapiou K, Kakouri E, Lambrou GI, Bethanis K, Tarantilis PA (2019) Antioxidant properties of Crocus Sativus L. and its constituents and relevance to neurodegenerative diseases; Focus on Alzheimer\u2019s and Parkinson\u2019s Disease. Curr Neuropharmacol 17(4):377\u2013402","journal-title":"Curr Neuropharmacol"},{"key":"4184_CR129","doi-asserted-by":"crossref","unstructured":"Jackson PA, Forster J, Khan J, Pouchieu C, Dubreuil S, Gaudout D et al (2021) Effects of Saffron Extract supplementation on Mood, Well-Being, and response to a Psychosocial Stressor in healthy adults: a Randomized, Double-Blind, Parallel Group, Clinical Trial. Front Nutr. ;7","DOI":"10.3389\/fnut.2020.606124"},{"issue":"14","key":"4184_CR130","doi-asserted-by":"publisher","first-page":"11","DOI":"10.14715\/cmb\/2016.62.14.2","volume":"62","author":"PK Pan","year":"2016","unstructured":"Pan PK, Qiao LY, Wen XN (2016) Safranal prevents rotenone-induced oxidative stress and apoptosis in an in vitro model of Parkinson\u2019s disease through regulating Keap1\/Nrf2 signaling pathway. Cell Mol Biol 62(14):11","journal-title":"Cell Mol Biol"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-024-04184-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-024-04184-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-024-04184-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T07:13:33Z","timestamp":1723101213000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-024-04184-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,12]]},"references-count":130,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["4184"],"URL":"https:\/\/doi.org\/10.1007\/s11064-024-04184-y","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,12]]},"assertion":[{"value":"8 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors confirm the original data of the manuscript. The authors have done effective literature searches using various electronic search tools. All the authors discussed the pharmacological, phytochemical, and radioprotective sections of the manuscript and further clarified that they have participated sincerely in the literature search, reviewing, and writing of the manuscript.1.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"There have been no competing interests indicated by the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}