{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:06:58Z","timestamp":1792120018500,"version":"4.4.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274656"],"award-info":[{"award-number":["82274656"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274656"],"award-info":[{"award-number":["82274656"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274656"],"award-info":[{"award-number":["82274656"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Graduate Student Scientific Research Foundation of the Anhui Higher Education Institutions of China","award":["YJS20210472"],"award-info":[{"award-number":["YJS20210472"]}]},{"name":"Graduate Student Scientific Research Foundation of the Anhui Higher Education Institutions of China","award":["YJS20210472"],"award-info":[{"award-number":["YJS20210472"]}]},{"name":"Graduate Student Scientific Research Foundation of the Anhui Higher Education Institutions of China","award":["YJS20210472"],"award-info":[{"award-number":["YJS20210472"]}]},{"name":"Research Funds of Center for Xin\u2019an Medicine and Modernization of Traditional Chinese Medicine of IHM","award":["2023CXMMTCM002"],"award-info":[{"award-number":["2023CXMMTCM002"]}]},{"name":"Research Funds of Center for Xin\u2019an Medicine and Modernization of Traditional Chinese Medicine of IHM","award":["2023CXMMTCM002"],"award-info":[{"award-number":["2023CXMMTCM002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ischemic stroke involves various pathological processes, among which ferroptosis is crucial. Previous studies by our group have indicated that electroacupuncture (EA) mitigates ferroptosis after ischemic stroke; however, the precise mechanism underlying this effect remains unclear. In the present study, we developed a rat model of middle cerebral artery occlusion\/reperfusion. We chose the main acupoint of the treatment methods of the \u201cAwakening and Opening of the Brain\u201d. Rats\u2019 neurological function and motor coordination were evaluated by neurological function score and the rotarod test, respectively, and the volume of cerebral infarction was analyzed by 2,3,5-triphenyltetrazolium chloride Staining. The cerebrovascular conditions were visualized by time-of-flight magentic resonance angiography. In addition, we detected changes in lipid peroxidation and endogenous antioxidant activity by measuring the malondialdehyde, glutathione, superoxide dismutase activities, glutathione\/oxidized glutathione and reduced nicotinamide adenine dinucleotide phosphate\/oxidized nicotinamide adenine dinucleotide phosphate ratios. Inductively coupled plasma-mass spectrometry, western blot, reverse transcription-polymerase chain reaction, fluoro-jade B staining, immunofluorescence analysis, and transmission electron microscopy were utilized to examine the influence of EA. The results indicate that EA treatment was effective in reversing neurological impairment, neuronal damage, and protecting mitochondrial morphology and decreasing the cerebral infarct volume in the middle cerebral artery occlusion\/reperfusion rat model. EA reduced iron levels, inhibited lipid peroxidation, increased endogenous antioxidant activity, modulated the expression of several ferroptosis-related proteins, and promoted nuclear factor-E2-related factor 2 (Nrf2) nuclear translocation. However, the protective effect of EA was hindered by the Nrf2 inhibitor ML385. These findings suggest that EA can suppress ferroptosis and decrease damage caused by cerebral ischemia\/reperfusion by activating Nrf2 and increasing the protein expression of solute carrier family 7 member 11 and glutathione peroxidase 4.<\/jats:p>","DOI":"10.1007\/s11064-024-04185-x","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T09:08:10Z","timestamp":1717146490000},"page":"2105-2119","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Electroacupuncture Downregulating Neuronal Ferroptosis in MCAO\/R Rats by Activating Nrf2\/SLC7A11\/GPX4 Axis"],"prefix":"10.1007","volume":"49","author":[{"given":"Wei","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjian","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"4185_CR1","doi-asserted-by":"publisher","first-page":"e897","DOI":"10.1016\/S2468-2667(21)00228-0","volume":"6","author":"Q Ma","year":"2021","unstructured":"Ma Q, Li R, Wang L, Yin P, Wang Y, Yan C, Ren Y, Qian Z, Vaughn MG, Mcmillin SE, Hay SI, Naghavi M, Cai M, Wang C, Zhang Z, Zhou M, Lin H, Yang Y (2021) Temporal trend and attributable risk factors of stroke burden in China, 1990\u20132019: an analysis for the global burden of Disease Study 2019. Lancet Public Health 6:e897\u2013e906. https:\/\/doi.org\/10.1016\/S2468-2667(21)00228-0","journal-title":"Lancet Public Health"},{"key":"4185_CR2","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","volume":"20","author":"GS Collaborators","year":"2021","unstructured":"Collaborators GS (2021) Global, regional, and national burden of stroke and its risk factors, 1990\u20132019: a systematic analysis for the global burden of Disease Study 2019. Lancet Neurol 20:795\u2013820. https:\/\/doi.org\/10.1016\/S1474-4422(21)00252-0","journal-title":"Lancet Neurol"},{"key":"4185_CR3","doi-asserted-by":"publisher","first-page":"e344","DOI":"10.1161\/STR.0000000000000211","volume":"50","author":"WJ Powers","year":"2019","unstructured":"Powers WJ, Rabinstein AA, Ackerson T, Adeoye OM, Bambakidis NC, Becker K, Biller J, Brown M, Demaerschalk BM, Hoh B, Jauch EC, Kidwell CS, Leslie-Mazwi TM, Ovbiagele B, Scott PA, Sheth KN, Southerland AM, Summers DV, Tirschwell DL (2019) Guidelines for the early management of patients with Acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of Acute ischemic stroke: a Guideline for Healthcare professionals from the American Heart Association\/American Stroke Association. Stroke 50:e344\u2013e418. https:\/\/doi.org\/10.1161\/STR.0000000000000211","journal-title":"Stroke"},{"key":"4185_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1056\/NEJMoa1706442","volume":"378","author":"RG Nogueira","year":"2018","unstructured":"Nogueira RG, Jadhav AP, Haussen DC, Bonafe A, Budzik RF, Bhuva P, Yavagal DR, Ribo M, Cognard C, Hanel RA, Sila CA, Hassan AE, Millan M, Levy EI, Mitchell P, Chen M, English JD, Shah QA, Silver FL, Pereira VM, Mehta BP, Baxter BW, Abraham MG, Cardona P, Veznedaroglu E, Hellinger FR, Feng L, Kirmani JF, Lopes DK, Jankowitz BT, Frankel MR, Costalat V, Vora NA, Yoo AJ, Malik AM, Furlan AJ, Rubiera M, Aghaebrahim A, Olivot J-M, Tekle WG, Shields R, Graves T, Lewis RJ, Smith WS, Liebeskind DS, Saver JL, Jovin TG, Investigators DT (2018) Thrombectomy 6 to 24 hours after stroke with a mismatch between Deficit and Infarct. N Engl J Med 378:11\u201321. https:\/\/doi.org\/10.1056\/NEJMoa1706442","journal-title":"N Engl J Med"},{"key":"4185_CR5","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1056\/NEJMoa1713973","volume":"378","author":"GW Albers","year":"2018","unstructured":"Albers GW, Marks MP, Kemp S, Christensen S, Tsai JP, Ortega-Gutierrez S, Mctaggart RA, Torbey MT, Kim-Tenser M, Leslie-Mazwi T, Sarraj A, Kasner SE, Ansari SA, Yeatts SD, Hamilton S, Mlynash M, Heit JJ, Zaharchuk G, Kim S, Carrozzella J, Palesch YY, Demchuk AM, Bammer R, Lavori PW, Broderick JP, Lansberg MG (2018) Thrombectomy for Stroke at 6 to 16 hours with selection by Perfusion Imaging. N Engl J Med 378:708\u2013718. https:\/\/doi.org\/10.1056\/NEJMoa1713973","journal-title":"N Engl J Med"},{"key":"4185_CR6","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1007\/s12975-020-00806-z","volume":"11","author":"A Datta","year":"2020","unstructured":"Datta A, Sarmah D, Mounica L, Kaur H, Kesharwani R, Verma G, Veeresh P, Kotian V, Kalia K, Borah A, Wang X, Dave KR, Yavagal DR, Bhattacharya P (2020) Cell death pathways in ischemic stroke and targeted pharmacotherapy. Translational Stroke Res 11:1185\u20131202. https:\/\/doi.org\/10.1007\/s12975-020-00806-z","journal-title":"Translational Stroke Res"},{"key":"4185_CR7","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s10072-017-2938-1","volume":"38","author":"SE Khoshnam","year":"2017","unstructured":"Khoshnam SE, Winlow W, Farzaneh M, Farbood Y, Moghaddam HF (2017) Pathogenic mechanisms following ischemic stroke. Neurol Sciences: Official J Italian Neurol Soc Italian Soc Clin Neurophysiol 38:1167\u20131186. https:\/\/doi.org\/10.1007\/s10072-017-2938-1","journal-title":"Neurol Sciences: Official J Italian Neurol Soc Italian Soc Clin Neurophysiol"},{"key":"4185_CR8","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","volume":"11","author":"J Li","year":"2020","unstructured":"Li J, Cao F, Yin HL, Huang ZJ, Lin ZT, Mao N, Sun B, Wang G (2020) Ferroptosis: past, present and future. Cell Death Dis 11:88. https:\/\/doi.org\/10.1038\/s41419-020-2298-2","journal-title":"Cell Death Dis"},{"key":"4185_CR9","doi-asserted-by":"publisher","unstructured":"Dixon Sj, Lemberg Kathryn m, Lamprecht Michael r, Skouta R Zaitsev Eleina m, Gleason Caroline e, Patel Darpan n, Bauer Andras j, Cantley Alexandra m, Yang Wan s, Morrison B, Stockwell Brent r (2012) Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death. Cell 149:1060\u20131072. https:\/\/doi.org\/10.1016\/j.cell.2012.03.042","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"4185_CR10","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1007\/s12035-021-02706-1","volume":"59","author":"YF Xu","year":"2022","unstructured":"Xu YF, Liu Y, Li KX, Yuan D, Yang S, Zhou L, Zhao Y, Miao SY, Lv CH, Zhao J (2022) COX-2\/PGE2 pathway inhibits the Ferroptosis Induced by Cerebral Ischemia Reperfusion. Mol Neurobiol 59:1619\u20131631. https:\/\/doi.org\/10.1007\/s12035-021-02706-1","journal-title":"Mol Neurobiol"},{"key":"4185_CR11","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1007\/s10571-020-00850-1","volume":"41","author":"YC Li","year":"2021","unstructured":"Li YC, Liu Y, Wu P, Tian Y, Liu BB, Wang JJ, Bihl J, Shi HZ (2021) Inhibition of ferroptosis alleviates early brain Injury after Subarachnoid Hemorrhage in Vitro and in vivo via reduction of lipid peroxidation. Cell Mol Neurobiol 41:263\u2013278. https:\/\/doi.org\/10.1007\/s10571-020-00850-1","journal-title":"Cell Mol Neurobiol"},{"key":"4185_CR12","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1007\/s12264-020-00620-5","volume":"37","author":"Y Cao","year":"2021","unstructured":"Cao Y, Li Y, He C, Yan F, Li JR, Xu HZ, Zhuang JF, Zhou H, Peng YC, Fu XJ, Lu XY, Yao Y, Wei YY, Tong Y, Zhou YF, Wang L (2021) Selective ferroptosis inhibitor Liproxstatin-1 attenuates neurological deficits and Neuroinflammation after Subarachnoid Hemorrhage. Neurosci Bull 37:535\u2013549. https:\/\/doi.org\/10.1007\/s12264-020-00620-5","journal-title":"Neurosci Bull"},{"key":"4185_CR13","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.brainresbull.2019.08.013","volume":"153","author":"B Chen","year":"2019","unstructured":"Chen B, Chen ZH, Liu MJ, Gao XR, Cheng YJ, Wei YX, Wu ZB, Cui DR, Shang HB (2019) Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects. Brain Res Bull 153:122\u2013132. https:\/\/doi.org\/10.1016\/j.brainresbull.2019.08.013","journal-title":"Brain Res Bull"},{"key":"4185_CR14","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1161\/STROKEAHA.116.015609","volume":"48","author":"M Zille","year":"2017","unstructured":"Zille M, Karuppagounder SS, Chen Y, Gough PJ, Bertin J, Finger J, Milner TA, Jonas EA, Ratan RR (2017) Neuronal death after hemorrhagic stroke in Vitro and in vivo shares features of ferroptosis and Necroptosis. Stroke 48:1033\u20131043. https:\/\/doi.org\/10.1161\/STROKEAHA.116.015609","journal-title":"Stroke"},{"key":"4185_CR15","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1038\/mp.2017.171","volume":"22","author":"Q-Z Tuo","year":"2017","unstructured":"Tuo Q-Z, Lei P, Jackman KA, Li X-L, Xiong H, Li X-L, Liuyang Z-Y, Roisman L, Zhang S-T, Ayton S, Wang Q, Crouch PJ, Ganio K, Wang X-C, Pei L, Adlard PA, Lu Y-M, Cappai R, Wang J-Z, Liu R, Bush AI (2017) Tau-mediated iron export prevents ferroptotic damage after ischemic stroke. Mol Psychiatry 22:1520\u20131530. https:\/\/doi.org\/10.1038\/mp.2017.171","journal-title":"Mol Psychiatry"},{"key":"4185_CR16","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.cell.2019.03.032","volume":"177","author":"I Alim","year":"2019","unstructured":"Alim I, Caulfield JT, Chen Y, Swarup V, Geschwind DH, Ivanova E, Seravalli J, Ai Y, Sansing LH, Ste Marie EJ, Hondal RJ, Mukherjee S, Cave JW, Sagdullaev BT, Karuppagounder SS, Ratan RR (2019) Selenium drives a Transcriptional Adaptive Program to Block Ferroptosis and treat stroke. Cell 177:1262\u20131279e1225. https:\/\/doi.org\/10.1016\/j.cell.2019.03.032","journal-title":"Cell"},{"key":"4185_CR17","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","volume":"172","author":"I Ingold","year":"2018","unstructured":"Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T, Mehr L, Aichler M, Walch A, Lamp D, Jastroch M, Miyamoto S, Wurst W, Ursini F, Arn\u00e9r ESJ, Fradejas-Villar N, Schweizer U, Zischka H, Friedmann Angeli JP, Conrad M (2018) Selenium utilization by GPX4 is required to Prevent Hydroperoxide-Induced ferroptosis. Cell 172:409\u2013422e421. https:\/\/doi.org\/10.1016\/j.cell.2017.11.048","journal-title":"Cell"},{"key":"4185_CR18","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.tips.2017.02.005","volume":"38","author":"JPF Angeli","year":"2017","unstructured":"Angeli JPF, Shah R, Pratt DA, Conrad M (2017) Ferroptosis inhibition: mechanisms and opportunities. Trends Pharmacol Sci 38:489\u2013498. https:\/\/doi.org\/10.1016\/j.tips.2017.02.005","journal-title":"Trends Pharmacol Sci"},{"key":"4185_CR19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","volume":"26","author":"WS Yang","year":"2016","unstructured":"Yang WS, Stockwell BR (2016) Ferroptosis: death by lipid peroxidation. Trends Cell Biol 26:165\u2013176. https:\/\/doi.org\/10.1016\/j.tcb.2015.10.014","journal-title":"Trends Cell Biol"},{"key":"4185_CR20","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang WS, Sriramaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB, Brown LM, Girotti AW, Cornish VW, Schreiber SL, Stockwell BR (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell 156:317\u2013331. https:\/\/doi.org\/10.1016\/j.cell.2013.12.010","journal-title":"Cell"},{"key":"4185_CR21","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"JP Friedmann Angeli","year":"2014","unstructured":"Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, R\u00e5dmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, F\u00f6rster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O\u2019donnell VB, Kagan VE, Schick JA, Conrad M (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 16:1180\u20131191. https:\/\/doi.org\/10.1038\/ncb3064","journal-title":"Nat Cell Biol"},{"key":"4185_CR22","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/antiox10010009","volume":"10","author":"S Ananth","year":"2020","unstructured":"Ananth S, Miyauchi S, Thangaraju M, Jadeja RN, Bartoli M, Ganapathy V, Martin PM (2020) Selenomethionine (Se-Met) induces the Cystine\/Glutamate exchanger SLC7A11 in cultured human retinal pigment epithelial (RPE) cells: implications for antioxidant therapy in aging retina. Antioxid (Basel Switzerland) 10:9. https:\/\/doi.org\/10.3390\/antiox10010009","journal-title":"Antioxid (Basel Switzerland)"},{"key":"4185_CR23","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"BR Stockwell","year":"2017","unstructured":"Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gasc\u00f3n S, Hatzios SK, Kagan VE, Noel K, Jiang X, Linkermann A, Murphy ME, Overholtzer M, Oyagi A, Pagnussat GC, Park J, Ran Q, Rosenfeld CS, Salnikow K, Tang D, Torti FM, Torti SV, Toyokuni S, Woerpel KA, Zhang DD (2017) Ferroptosis: a regulated cell death Nexus linking metabolism, Redox Biology, and Disease. Cell 171:273\u2013285. https:\/\/doi.org\/10.1016\/j.cell.2017.09.021","journal-title":"Cell"},{"key":"4185_CR24","doi-asserted-by":"publisher","first-page":"101107","DOI":"10.1016\/j.redox.2019.101107","volume":"23","author":"M Dodson","year":"2019","unstructured":"Dodson M, Castro-Portuguez R, Zhang DD (2019) NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol 23:101107. https:\/\/doi.org\/10.1016\/j.redox.2019.101107","journal-title":"Redox Biol"},{"key":"4185_CR25","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1089\/ars.2017.7176","volume":"29","author":"MJ Kerins","year":"2018","unstructured":"Kerins MJ, Ooi A (2018) The roles of NRF2 in modulating Cellular Iron Homeostasis. Antioxid Redox Signal 29:1756\u20131773. https:\/\/doi.org\/10.1089\/ars.2017.7176","journal-title":"Antioxid Redox Signal"},{"key":"4185_CR26","doi-asserted-by":"publisher","first-page":"6006","DOI":"10.1007\/s12035-016-0111-0","volume":"54","author":"RR Zhang","year":"2017","unstructured":"Zhang RR, Xu MX, Wang Y, Xie F, Zhang G, Qin XY (2017) Nrf2-a promising therapeutic target for defensing against oxidative stress in stroke. Mol Neurobiol 54:6006\u20136017. https:\/\/doi.org\/10.1007\/s12035-016-0111-0","journal-title":"Mol Neurobiol"},{"key":"4185_CR27","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","volume":"1863","author":"SMU Ahmed","year":"2017","unstructured":"Ahmed SMU, Luo L, Namani A, Wang XJ, Tang X (2017) Nrf2 signaling pathway: pivotal roles in inflammation. Biochim Et Biophys Acta Mol Basis Disease 1863:585\u2013597. https:\/\/doi.org\/10.1016\/j.bbadis.2016.11.005","journal-title":"Biochim Et Biophys Acta Mol Basis Disease"},{"key":"4185_CR28","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s10571-022-01196-6","volume":"43","author":"YF Xu","year":"2023","unstructured":"Xu YF, Li KX, Zhao Y, Zhou L, Liu Y, Zhao J (2023) Role of ferroptosis in stroke. Cell Mol Neurobiol 43:205\u2013222. https:\/\/doi.org\/10.1007\/s10571-022-01196-6","journal-title":"Cell Mol Neurobiol"},{"key":"4185_CR29","doi-asserted-by":"publisher","first-page":"354","DOI":"10.13702\/j.1000-0607.20210426","volume":"47","author":"J Yao","year":"2022","unstructured":"Yao J, Zou W (2022) Mechanism of acupuncture in treatment of ischemic stroke:a review. Acupunct Res 47:354\u2013361. https:\/\/doi.org\/10.13702\/j.1000-0607.20210426","journal-title":"Acupunct Res"},{"key":"4185_CR30","doi-asserted-by":"publisher","first-page":"87","DOI":"10.13702\/j.1000-0607.200819","volume":"46","author":"G Li","year":"2021","unstructured":"Li G, Li X, Dong J, Wu Y, Han Y (2021) Effect of electroacupuncture on neurovascular unit and Wnt\/\u03b2-catenin signaling in rats with cerebral ischemia. Acupunct Res 46:87\u201394. https:\/\/doi.org\/10.13702\/j.1000-0607.200819","journal-title":"Acupunct Res"},{"key":"4185_CR31","doi-asserted-by":"publisher","unstructured":"Yang M (2007) Progress of Clinical Research on awakening and opening of the Brain acupuncture in the last 10 years. J Liaoning Univ Traditional Chin Med 196\u2013198. https:\/\/doi.org\/10.13194\/j.jlunivtcm.2007.06.198.yangmy.089","DOI":"10.13194\/j.jlunivtcm.2007.06.198.yangmy.089"},{"key":"4185_CR32","doi-asserted-by":"publisher","unstructured":"Shi X (2005) Clinical study on 9005 cases of Stroke Disease treated by acupuncture method of awakening and opening of the brain. Guiding J Traditional Chin Med Pharm 3\u20135. https:\/\/doi.org\/10.13862\/j.cnki.cn43-1446\/r.2005.01.002","DOI":"10.13862\/j.cnki.cn43-1446\/r.2005.01.002"},{"key":"4185_CR33","doi-asserted-by":"publisher","first-page":"619043","DOI":"10.3389\/fneur.2021.619043","volume":"12","author":"G Li","year":"2021","unstructured":"Li G, Li X, Dong J, Han Y (2021) Electroacupuncture ameliorates cerebral ischemic Injury by inhibiting Ferroptosis. Front Neurol 12:619043. https:\/\/doi.org\/10.3389\/fneur.2021.619043","journal-title":"Front Neurol"},{"key":"4185_CR34","doi-asserted-by":"publisher","first-page":"77","DOI":"10.19879\/j.cnki.1005-5304.202206214","volume":"30","author":"L X","year":"2023","unstructured":"X L, S L, J D, Y H (2023) Effects of Electroacupuncture serum of rats on oxygen-glucose deprivation-induced hippocampal neuronal ferroptosis. Chin J Inform Traditional Chin Med 30:77\u201381. https:\/\/doi.org\/10.19879\/j.cnki.1005-5304.202206214","journal-title":"Chin J Inform Traditional Chin Med"},{"key":"4185_CR35","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","volume":"20","author":"EZ Longa","year":"1989","unstructured":"Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84\u201391. https:\/\/doi.org\/10.1161\/01.STR.20.1.84","journal-title":"Stroke"},{"key":"4185_CR36","doi-asserted-by":"publisher","unstructured":"Li C, Hua X, Zhou H, Song D, Hu Y (1992) Study on the bitmap spectrum of acupuncture and moxibustion in guinea pigs. Shanghai J Acupunc Moxib 28\u201330. https:\/\/doi.org\/10.13460\/j.issn.1005-0957.1992.02.021","DOI":"10.13460\/j.issn.1005-0957.1992.02.021"},{"key":"4185_CR37","doi-asserted-by":"publisher","unstructured":"Wu C, Duan F, Yang R, Dai Y, Chen X, Li S (2023) 15, 16-Dihydrotanshinone I protects against ischemic stroke by inhibiting ferroptosis via the activation of nuclear factor erythroid 2-related factor 2. https:\/\/doi.org\/10.1016\/j.phymed.2023.154790. Phytomedicine 114","DOI":"10.1016\/j.phymed.2023.154790"},{"key":"4185_CR38","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.1021\/acschembio.6b00651","volume":"11","author":"A Singh","year":"2016","unstructured":"Singh A, Venkannagari S, Oh KH, Zhang Y-Q, Rohde JM, Liu L, Nimmagadda S, Sudini K, Brimacombe KR, Gajghate S, Ma J, Wang A, Xu X, Shahane SA, Xia M, Woo J, Mensah GA, Wang Z, Ferrer M, Gabrielson E, Li Z, Rastinejad F, Shen M, Boxer MB, Biswal S (2016) Small molecule inhibitor of NRF2 selectively intervenes therapeutic resistance in KEAP1-Deficient NSCLC tumors. ACS Chem Biol 11:3214\u20133225. https:\/\/doi.org\/10.1021\/acschembio.6b00651","journal-title":"ACS Chem Biol"},{"key":"4185_CR39","doi-asserted-by":"publisher","first-page":"155529","DOI":"10.1016\/j.phymed.2024.155529","volume":"128","author":"Y Hou","year":"2024","unstructured":"Hou Y, Fan F, Xie N, Zhang Y, Wang X, Meng X (2024) Rhodiola crenulata alleviates hypobaric hypoxia-induced brain injury by maintaining BBB integrity and balancing energy metabolism dysfunction. Phytomedicine 128:155529. https:\/\/doi.org\/10.1016\/j.phymed.2024.155529","journal-title":"Phytomedicine"},{"key":"4185_CR40","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41556-020-0461-8","volume":"22","author":"H Lee","year":"2020","unstructured":"Lee H, Zandkarimi F, Zhang Y, Meena JK, Kim J, Zhuang L, Tyagi S, Ma L, Westbrook TF, Steinberg GR, Nakada D, Stockwell BR, Gan B (2020) Energy-stress-mediated AMPK activation inhibits ferroptosis. Nat Cell Biol 22:225\u2013234. https:\/\/doi.org\/10.1038\/s41556-020-0461-8","journal-title":"Nat Cell Biol"},{"key":"4185_CR41","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s40880-018-0288-x","volume":"38","author":"P Koppula","year":"2018","unstructured":"Koppula P, Zhang Y, Zhuang L, Gan B (2018) Amino acid transporter SLC7A11\/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer Commun 38:12. https:\/\/doi.org\/10.1186\/s40880-018-0288-x","journal-title":"Cancer Commun"},{"key":"4185_CR42","doi-asserted-by":"publisher","first-page":"9067610","DOI":"10.1155\/2020\/9067610","volume":"2020","author":"H Ma","year":"2020","unstructured":"Ma H, Wang X, Zhang W, Li H, Zhao W, Sun J, Yang M (2020) Melatonin suppresses Ferroptosis Induced by high glucose via activation of the Nrf2\/HO-1 signaling pathway in type 2 Diabetic osteoporosis. Oxidative Med Cell Longev 2020:9067610. https:\/\/doi.org\/10.1155\/2020\/9067610","journal-title":"Oxidative Med Cell Longev"},{"key":"4185_CR43","doi-asserted-by":"publisher","first-page":"3525","DOI":"10.1007\/s11064-022-03697-8","volume":"47","author":"Q Zhang","year":"2022","unstructured":"Zhang Q, Jia M, Wang Y, Wang Q, Wu J (2022) Cell death mechanisms in cerebral ischemia-reperfusion Injury. Neurochem Res 47:3525\u20133542. https:\/\/doi.org\/10.1007\/s11064-022-03697-8","journal-title":"Neurochem Res"},{"key":"4185_CR44","doi-asserted-by":"publisher","first-page":"14715","DOI":"10.1021\/acsnano.0c00764","volume":"14","author":"X Guo","year":"2020","unstructured":"Guo X, Liu F, Deng J, Dai P, Qin Y, Li Z, Wang B, Fan A, Wang Z, Zhao Y (2020) Electron-accepting Micelles deplete reduced Nicotinamide Adenine Dinucleotide phosphate and impair two antioxidant cascades for Ferroptosis-Induced Tumor Eradication. ACS Nano 14:14715\u201314730. https:\/\/doi.org\/10.1021\/acsnano.0c00764","journal-title":"ACS Nano"},{"key":"4185_CR45","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.molcel.2020.11.024","volume":"81","author":"B Yan","year":"2021","unstructured":"Yan B, Ai Y, Sun Q, Ma Y, Cao Y, Wang J, Zhang Z, Wang X (2021) Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1. Mol Cell 81:355\u2013369e310. https:\/\/doi.org\/10.1016\/j.molcel.2020.11.024","journal-title":"Mol Cell"},{"key":"4185_CR46","doi-asserted-by":"publisher","first-page":"102021","DOI":"10.1016\/j.redox.2021.102021","volume":"45","author":"S Jang","year":"2021","unstructured":"Jang S, Chapa-Dubocq XR, Tyurina YY, St Croix CM, Kapralov AA, Tyurin VA, Bay\u0131r H, Kagan VE, Javadov S (2021) Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes. Redox Biol 45:102021. https:\/\/doi.org\/10.1016\/j.redox.2021.102021","journal-title":"Redox Biol"},{"key":"4185_CR47","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1111\/bph.15364","volume":"178","author":"D Li","year":"2021","unstructured":"Li D, Liu B, Fan Y, Liu M, Han B, Meng Y, Xu X, Song Z, Liu X, Hao Q, Duan X, Nakai A, Chang Y, Cao P, Tan K (2021) Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis. Br J Pharmacol 178:1182\u20131199. https:\/\/doi.org\/10.1111\/bph.15364","journal-title":"Br J Pharmacol"},{"key":"4185_CR48","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.molmed.2022.02.003","volume":"28","author":"Z-L Wang","year":"2022","unstructured":"Wang Z-L, Yuan L, Li W, Li J-Y (2022) Ferroptosis in Parkinson\u2019s disease: glia-neuron crosstalk. Trends Mol Med 28:258\u2013269. https:\/\/doi.org\/10.1016\/j.molmed.2022.02.003","journal-title":"Trends Mol Med"},{"key":"4185_CR49","doi-asserted-by":"publisher","first-page":"5001","DOI":"10.3390\/molecules26165001","volume":"26","author":"M Farina","year":"2021","unstructured":"Farina M, Vieira LE, Buttari B, Profumo E, Saso L (2021) The Nrf2 pathway in ischemic stroke: a review. Molecules 26:5001. https:\/\/doi.org\/10.3390\/molecules26165001","journal-title":"Molecules"},{"key":"4185_CR50","doi-asserted-by":"publisher","first-page":"7253","DOI":"10.1080\/21655979.2022.2045830","volume":"13","author":"X Pan","year":"2022","unstructured":"Pan X, Fan J, Peng F, Xiao L, Yang Z (2022) SET domain containing 7 promotes oxygen-glucose deprivation\/reoxygenation-induced PC12 cell inflammation and oxidative stress by regulating Keap1\/Nrf2\/ARE and NF-\u03baB pathways. Bioengineered 13:7253\u20137261. https:\/\/doi.org\/10.1080\/21655979.2022.2045830","journal-title":"Bioengineered"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-024-04185-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-024-04185-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-024-04185-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T03:44:19Z","timestamp":1720583059000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-024-04185-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["4185"],"URL":"https:\/\/doi.org\/10.1007\/s11064-024-04185-x","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,31]]},"assertion":[{"value":"13 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 May 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures were conducted in accordance with the guidelines provided by the Chinese Council on Animal Care and received approval from the Animal Ethics Committees of the Anhui University of Chinese Medicine (AHUCM-rats-2023132).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors do not have any relevant financial or non-financial interests to disclose. Figure\u00a07 was generated using Figdraw ().","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}