{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:36:41Z","timestamp":1790044601734,"version":"4.0.1"},"reference-count":68,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171334"],"award-info":[{"award-number":["82171334"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chongqing Science and Health Joint Medical Research Project","award":["2023ZDXM016"],"award-info":[{"award-number":["2023ZDXM016"]}]},{"name":"Individualized training program for the excellent talent pool of the Army Medical University"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s11064-024-04206-9","type":"journal-article","created":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T06:04:50Z","timestamp":1721109890000},"page":"2821-2841","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Single-cell RNA Sequencing Identifies a Novel Subtype of Microglia with High Cd74 Expression that Facilitates White Matter Inflammation During Chronic Cerebral Hypoperfusion"],"prefix":"10.1007","volume":"49","author":[{"given":"Wenchao","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,16]]},"reference":[{"key":"4206_CR1","doi-asserted-by":"publisher","first-page":"1698","DOI":"10.1016\/S0140-6736(15)00463-8","volume":"386","author":"JT O\u2019Brien","year":"2015","unstructured":"O\u2019Brien JT, Thomas A (2015) Vascular dementia. Lancet 386:1698\u20131706. https:\/\/doi.org\/10.1016\/S0140-6736(15)00463-8","journal-title":"Lancet"},{"key":"4206_CR2","doi-asserted-by":"publisher","first-page":"e661","DOI":"10.1016\/S2468-2667(20)30185-7","volume":"5","author":"L Jia","year":"2020","unstructured":"Jia L, Du Y, Chu L et al (2020) Prevalence, risk factors, and management of dementia and mild cognitive impairment in adults aged 60 years or older in China: a cross-sectional study. Lancet Public Health 5:e661\u2013e671. https:\/\/doi.org\/10.1016\/S2468-2667(20)30185-7","journal-title":"Lancet Public Health"},{"key":"4206_CR3","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1159\/000160960","volume":"26","author":"JH Jhoo","year":"2008","unstructured":"Jhoo JH, Kim KW, Huh Y et al (2008) Prevalence of dementia and its subtypes in an elderly urban Korean population: results from the Korean Longitudinal Study on Health and Aging (KLoSHA). Dement Geriatr Cogn Disord 26:270\u2013276. https:\/\/doi.org\/10.1159\/000160960","journal-title":"Dement Geriatr Cogn Disord"},{"key":"4206_CR4","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/bpa.12223","volume":"25","author":"S Love","year":"2015","unstructured":"Love S, Miners JS (2015) White matter hypoperfusion and damage in dementia: post-mortem assessment. Brain Pathol 25:99\u2013107. https:\/\/doi.org\/10.1111\/bpa.12223","journal-title":"Brain Pathol"},{"key":"4206_CR5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1038\/nrneurol.2015.10","volume":"11","author":"ND Prins","year":"2015","unstructured":"Prins ND, Scheltens P (2015) White matter hyperintensities, cognitive impairment and dementia: an update. Nat Rev Neurol 11:157\u2013165. https:\/\/doi.org\/10.1038\/nrneurol.2015.10","journal-title":"Nat Rev Neurol"},{"key":"4206_CR6","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.14336\/AD.2021.0414","volume":"12","author":"X Wu","year":"2021","unstructured":"Wu X, Ya J, Zhou D et al (2021) Pathogeneses and imaging features of cerebral white matter lesions of vascular origins. Aging Dis 12:2031\u20132051. https:\/\/doi.org\/10.14336\/AD.2021.0414https:\/\/doi.org\/10.14336\/AD.2021.0414","journal-title":"Aging Dis"},{"key":"4206_CR7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1161\/STROKEAHA.119.027115","volume":"51","author":"H Jin","year":"2020","unstructured":"Jin H, Ding Z, Lian S et al (2020) Prevalence and risk factors of white matter lesions in tibetan patients without acute stroke. Stroke 51:149\u2013153. https:\/\/doi.org\/10.1161\/STROKEAHA.119.027115","journal-title":"Stroke"},{"key":"4206_CR8","doi-asserted-by":"publisher","first-page":"3670","DOI":"10.1007\/s12035-016-9915-1","volume":"54","author":"SQ Du","year":"2017","unstructured":"Du SQ, Wang XR, Xiao LY et al (2017) Molecular mechanisms of vascular dementia: what can be learned from animal models of chronic cerebral hypoperfusion? Mol Neurobiol 54:3670\u20133682. https:\/\/doi.org\/10.1007\/s12035-016-9915-1","journal-title":"Mol Neurobiol"},{"key":"4206_CR9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13024-021-00506-8","volume":"17","author":"L Poh","year":"2022","unstructured":"Poh L, Sim WL, Jo DG et al (2022) The role of inflammasomes in vascular cognitive impairment. Mol Neurodegener 17:4. https:\/\/doi.org\/10.1186\/s13024-021-00506-8","journal-title":"Mol Neurodegener"},{"key":"4206_CR10","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.1007\/s11064-016-2056-0","volume":"41","author":"P Cheng","year":"2016","unstructured":"Cheng P, Zuo X, Ren Y et al (2016) Adenosine A1-receptors modulate mTOR signaling to regulate white matter inflammatory lesions induced by chronic cerebral hypoperfusion. Neurochem Res 41:3272\u20133277. https:\/\/doi.org\/10.1007\/s11064-016-2056-0","journal-title":"Neurochem Res"},{"key":"4206_CR11","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1111\/j.1365-2990.2007.00890.x","volume":"33","author":"JE Simpson","year":"2007","unstructured":"Simpson JE, Ince PG, Higham CE et al (2007) Microglial activation in white matter lesions and nonlesional white matter of ageing brains. Neuropathol Appl Neurobiol 33:670\u2013683. https:\/\/doi.org\/10.1111\/j.1365-2990.2007.00890.x","journal-title":"Neuropathol Appl Neurobiol"},{"key":"4206_CR12","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1089\/ars.2020.8076","volume":"33","author":"C Cervellati","year":"2020","unstructured":"Cervellati C, Trentini A, Pecorelli A et al (2020) Inflammation in neurological disorders: the thin boundary between brain and periphery. Antioxid Redox Signal 33:191\u2013210. https:\/\/doi.org\/10.1089\/ars.2020.8076","journal-title":"Antioxid Redox Signal"},{"key":"4206_CR13","doi-asserted-by":"publisher","first-page":"114301","DOI":"10.1016\/j.bbr.2023.114301","volume":"442","author":"Y Xiao","year":"2023","unstructured":"Xiao Y, Guan T, Yang X et al (2023) Baicalin facilitates remyelination and suppresses neuroinflammation in rats with chronic cerebral hypoperfusion by activating Wnt\/\u03b2-catenin and inhibiting NF-\u03baB signaling. Behav Brain Res 442:114301. https:\/\/doi.org\/10.1016\/j.bbr.2023.114301","journal-title":"Behav Brain Res"},{"key":"4206_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cns.14089","volume":"00","author":"SH Su","year":"2023","unstructured":"Su SH, Chen M, Wu YF et al (2023) Fecal microbiota transplantation and short-chain fatty acids protected against cognitive dysfunction in a rat model of chronic cerebral hypoperfusion. CNS Neurosci Ther 00:1\u201317. https:\/\/doi.org\/10.1111\/cns.14089","journal-title":"CNS Neurosci Ther"},{"key":"4206_CR15","doi-asserted-by":"publisher","first-page":"903565","DOI":"10.3389\/fneur.2022.903565","volume":"13","author":"M Yu","year":"2022","unstructured":"Yu M, Zheng X, Cheng F et al (2022) Metformin, rapamycin, or nicotinamide mononucleotide pretreatment attenuate cognitive impairment after cerebral hypoperfusion by inhibiting microglial phagocytosis. Front Neurol 13:903565. https:\/\/doi.org\/10.3389\/fneur.2022.903565","journal-title":"Front Neurol"},{"key":"4206_CR16","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.neuropharm.2018.06.019","volume":"138","author":"A Santiago","year":"2018","unstructured":"Santiago A, Soares LM, Schepers M et al (2018) Roflumilast promotes memory recovery and attenuates white matter injury in aged rats subjected to chronic cerebral hypoperfusion. Neuropharmacology 138:360\u2013370. https:\/\/doi.org\/10.1016\/j.neuropharm.2018.06.019","journal-title":"Neuropharmacology"},{"key":"4206_CR17","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1186\/s13046-022-02535-7","volume":"41","author":"MM Caffarel","year":"2022","unstructured":"Caffarel MM, Braza MS (2022) Microglia and metastases to the central nervous system: victim, ravager, or something else? J Exp Clin Cancer Res 41:327. https:\/\/doi.org\/10.1186\/s13046-022-02535-7","journal-title":"J Exp Clin Cancer Res"},{"key":"4206_CR18","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1038\/nn.4338","volume":"19","author":"RM Ransohoff","year":"2016","unstructured":"Ransohoff RM (2016) A polarizing question: do M1 and M2 microglia exist? Nat Neurosci 19:987\u2013991. https:\/\/doi.org\/10.1038\/nn.4338","journal-title":"Nat Neurosci"},{"key":"4206_CR19","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1038\/s42003-022-04081-6","volume":"5","author":"LM Healy","year":"2022","unstructured":"Healy LM, Zia S, Plemel JR (2022) Towards a definition of microglia heterogeneity. Commun Biol 5:1114. https:\/\/doi.org\/10.1038\/s42003-022-04081-6","journal-title":"Commun Biol"},{"key":"4206_CR20","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.cmet.2023.03.006","volume":"35","author":"P Hasel","year":"2023","unstructured":"Hasel P, Aisenberg WH, Bennett FC et al (2023) Molecular and metabolic heterogeneity of astrocytes and microglia. Cell Metab 35:555\u2013570. https:\/\/doi.org\/10.1016\/j.cmet.2023.03.006","journal-title":"Cell Metab"},{"key":"4206_CR21","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","volume":"169","author":"H Keren-Shaul","year":"2017","unstructured":"Keren-Shaul H, Spinrad A, Weiner A et al (2017) A unique microglia type associated with restricting development of Alzheimer\u2019s disease. Cell 169:1276\u20131290. https:\/\/doi.org\/10.1016\/j.cell.2017.05.018","journal-title":"Cell"},{"key":"4206_CR22","doi-asserted-by":"publisher","first-page":"102347","DOI":"10.1016\/j.redox.2022.102347","volume":"54","author":"S Kim","year":"2022","unstructured":"Kim S, Lee W, Jo H et al (2022) The antioxidant enzyme Peroxiredoxin-1 controls stroke-associated microglia against acute ischemic stroke. Redox Biol 54:102347. https:\/\/doi.org\/10.1016\/j.redox.2022.102347","journal-title":"Redox Biol"},{"key":"4206_CR23","doi-asserted-by":"publisher","first-page":"e163446","DOI":"10.1172\/JCI163446","volume":"133","author":"F Khan","year":"2023","unstructured":"Khan F, Pang L, Dunterman M et al (2023) Macrophages and microglia in glioblastoma: heterogeneity, plasticity, and therapy. J Clin Invest 133:e163446. https:\/\/doi.org\/10.1172\/JCI163446","journal-title":"J Clin Invest"},{"key":"4206_CR24","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/s41586-020-2795-6","volume":"587","author":"Y Li","year":"2020","unstructured":"Li Y, He X, Kawaguchi R et al (2020) Microglia-organized scar-free spinal cord repair in neonatal mice. Nature 587:613\u2013618. https:\/\/doi.org\/10.1038\/s41586-020-2795-6","journal-title":"Nature"},{"key":"4206_CR25","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.brainresrev.2007.01.003","volume":"54","author":"E Farkas","year":"2007","unstructured":"Farkas E, Luiten PG, Bari F et al (2007) Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases. Brain Res Rev 54:162\u2013180. https:\/\/doi.org\/10.1016\/j.brainresrev.2007.01.003","journal-title":"Brain Res Rev"},{"key":"4206_CR26","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-023-04050-3","author":"Y Wang","year":"2023","unstructured":"Wang Y, Cheng W, Chen X et al (2023) Serum proteomics identified TAFI as a potential molecule facilitating the Migration of Peripheral monocytes to Damaged White Matter during Chronic Cerebral Hypoperfusion. Neurochem Res https\/\/. https:\/\/doi.org\/10.1007\/s11064-023-04050-3","journal-title":"Neurochem Res https\/\/"},{"key":"4206_CR27","doi-asserted-by":"publisher","first-page":"112834","DOI":"10.1016\/j.jim.2020.112834","volume":"486","author":"J Pan","year":"2020","unstructured":"Pan J, Wan J (2020) Methodological comparison of FACS and MACS isolation of enriched microglia and astrocytes from mouse brain. J Immunol Methods 486:112834. https:\/\/doi.org\/10.1016\/j.jim.2020.112834","journal-title":"J Immunol Methods"},{"key":"4206_CR28","doi-asserted-by":"publisher","first-page":"14049","DOI":"10.1038\/ncomms14049","volume":"8","author":"GX Zheng","year":"2017","unstructured":"Zheng GX, Terry JM, Belgrader P et al (2017) Massively parallel digital transcriptional profiling of single cells. Nat Commun 8:14049. https:\/\/doi.org\/10.1038\/ncomms14049","journal-title":"Nat Commun"},{"key":"4206_CR29","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/nbt.4096","volume":"36","author":"A Butler","year":"2018","unstructured":"Butler A, Hoffman P, Smibert P et al (2018) Integrating single-cell transcriptomic data across different conditions, technologies, and species. Nat Biotechnol 36:411\u2013420. https:\/\/doi.org\/10.1038\/nbt.4096","journal-title":"Nat Biotechnol"},{"key":"4206_CR30","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","volume":"177","author":"T Stuart","year":"2019","unstructured":"Stuart T, Butler A, Hoffman P et al (2019) Comprehensive Integration of Single-Cell Data. Cell 177:1888\u20131902 https:\/\/. https:\/\/doi.org\/10.1016\/j.cell.2019.05.031","journal-title":"Cell"},{"key":"4206_CR31","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/j.cels.2019.03.003","volume":"8","author":"CS McGinnis","year":"2019","unstructured":"McGinnis CS, Murrow LM, Gartner ZJ (2019) DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors. Cell Syst 8:329\u2013337. https:\/\/doi.org\/10.1016\/j.cels.2019.03.003","journal-title":"Cell Syst"},{"key":"4206_CR32","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","volume":"20","author":"D Aran","year":"2019","unstructured":"Aran D, Looney AP, Liu L et al (2019) Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol 20:163\u2013172. https:\/\/doi.org\/10.1038\/s41590-018-0276-y","journal-title":"Nat Immunol"},{"key":"4206_CR33","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/nmeth.4150","volume":"14","author":"X Qiu","year":"2017","unstructured":"Qiu X, Hill A, Packer J et al (2017) Single-cell mRNA quantification and differential analysis with Census. Nat Methods 14:309\u2013315. https:\/\/doi.org\/10.1038\/nmeth.4150","journal-title":"Nat Methods"},{"key":"4206_CR34","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1038\/s41592-022-01547-7","volume":"19","author":"R Lin","year":"2022","unstructured":"Lin R, Zhou Y, Yan T et al (2022) Directed evolution of adeno-associated virus for efficient gene delivery to microglia. Nat Methods 19:976\u2013985. https:\/\/doi.org\/10.1038\/s41592-022-01547-7","journal-title":"Nat Methods"},{"key":"4206_CR35","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1097\/NEN.0000000000000174","volume":"74","author":"H Ran","year":"2015","unstructured":"Ran H, Duan W, Gong Z et al (2015) Critical contribution of adenosine A2A receptors in bone marrow-derived cells to white matter lesions induced by chronic cerebral hypoperfusion. J Neuropathol Exp Neurol 74:305\u2013318. https:\/\/doi.org\/10.1097\/NEN.0000000000000174","journal-title":"J Neuropathol Exp Neurol"},{"key":"4206_CR36","doi-asserted-by":"publisher","first-page":"2702","DOI":"10.26355\/eurrev_202204_28600","volume":"26","author":"YH Wang","year":"2022","unstructured":"Wang YH, Cheng C, Zuo XZ et al (2022) Inhibition of A2AR gene methylation alleviates white matter lesions in chronic cerebral hypoperfusion rats. Eur Rev Med Pharmacol Sci 26:2702\u20132711. https:\/\/doi.org\/10.26355\/eurrev_202204_28600","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"4206_CR37","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1016\/j.celrep.2018.08.001","volume":"24","author":"D Guneykaya","year":"2018","unstructured":"Guneykaya D, Ivanov A, Hernandez DP et al (2018) Transcriptional and translational differences of microglia from male and female brains. Cell Rep 24:2773\u20132783. https:\/\/doi.org\/10.1016\/j.celrep.2018.08.001","journal-title":"Cell Rep"},{"key":"4206_CR38","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.14336\/AD.2021.0520","volume":"12","author":"C Jin","year":"2021","unstructured":"Jin C, Shao Y, Zhang X et al (2021) A unique type of highly-activated microglia evoking brain inflammation via Mif\/Cd74 signaling axis in aged mice. Aging Dis 12:2125\u20132139. https:\/\/doi.org\/10.14336\/AD.2021.0520","journal-title":"Aging Dis"},{"key":"4206_CR39","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.neuron.2021.01.027","volume":"109","author":"S Safaiyan","year":"2021","unstructured":"Safaiyan S, Besson-Girard S, Kaya T et al (2021) White matter aging drives microglial diversity. Neuron 109:1100\u20131117. https:\/\/doi.org\/10.1016\/j.neuron.2021.01.027","journal-title":"Neuron"},{"key":"4206_CR40","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.neuron.2018.12.006","volume":"101","author":"Q Li","year":"2019","unstructured":"Li Q, Cheng Z, Zhou L et al (2019) Developmental heterogeneity of microglia and brain myeloid cells revealed by deep single-cell RNA sequencing. Neuron 101:207\u2013223. https:\/\/doi.org\/10.1016\/j.neuron.2018.12.006","journal-title":"Neuron"},{"key":"4206_CR41","doi-asserted-by":"publisher","first-page":"6176","DOI":"10.3390\/ijms20246176","volume":"20","author":"K Washida","year":"2019","unstructured":"Washida K, Hattori Y, Ihara M (2019) Animal models of chronic cerebral hypoperfusion: from mouse to primate. Int J Mol Sci 20:6176. https:\/\/doi.org\/10.3390\/ijms20246176","journal-title":"Int J Mol Sci"},{"key":"4206_CR42","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3390\/antiox12010098","volume":"12","author":"L Olivares-Gonz\u00e1lez","year":"2022","unstructured":"Olivares-Gonz\u00e1lez L, Velasco S, Gallego I et al (2022) An SPM-enriched marine oil supplement shifted microglia polarization toward M2, ameliorating retinal degeneration in rd10 mice. Antioxidants 12:98. https:\/\/doi.org\/10.3390\/antiox12010098","journal-title":"Antioxidants"},{"key":"4206_CR43","doi-asserted-by":"publisher","first-page":"105919","DOI":"10.1016\/j.nbd.2022.105919","volume":"175","author":"L Gallwitz","year":"2022","unstructured":"Gallwitz L, Schmidt L, Marques ARA et al (2022) Cathepsin D: analysis of its potential role as an amyloid beta degrading protease. Neurobiol Dis 175:105919. https:\/\/doi.org\/10.1016\/j.nbd.2022.105919","journal-title":"Neurobiol Dis"},{"key":"4206_CR44","doi-asserted-by":"publisher","first-page":"eabk0637","DOI":"10.1126\/science.abk0637","volume":"377","author":"ME Diaz-Ortiz","year":"2022","unstructured":"Diaz-Ortiz ME, Seo Y, Posavi M et al (2022) GPNMB confers risk for Parkinson\u2019s disease through interaction with \u03b1-synuclein. Science 377:eabk0637. https:\/\/doi.org\/10.1126\/science.abk0637","journal-title":"Science"},{"key":"4206_CR45","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.4049\/jimmunol.1402238","volume":"194","author":"S Haag","year":"2015","unstructured":"Haag S, Tuncel J, Thordardottir S et al (2015) Positional identification of RT1-B (HLA-DQ) as susceptibility locus for autoimmune arthritis. J Immunol 194:2539\u20132550. https:\/\/doi.org\/10.4049\/jimmunol.1402238","journal-title":"J Immunol"},{"key":"4206_CR46","doi-asserted-by":"publisher","first-page":"1049143","DOI":"10.3389\/fcvm.2022.1049143","volume":"9","author":"QL Li","year":"2022","unstructured":"Li QL, Tang J, Zhao L et al (2022) The role of CD74 in cardiovascular disease. Front Cardiovasc Med 9:1049143. https:\/\/doi.org\/10.3389\/fcvm.2022.1049143","journal-title":"Front Cardiovasc Med"},{"key":"4206_CR47","doi-asserted-by":"publisher","first-page":"5012","DOI":"10.3390\/cancers13195012","volume":"13","author":"KD Wurster","year":"2021","unstructured":"Wurster KD, Costanza M, Kreher S et al (2021) Aberrant expression of and cell death induction by engagement of the MHC-II chaperone CD74 in anaplastic large cell lymphoma (ALCL). Cancers 13:5012. https:\/\/doi.org\/10.3390\/cancers13195012","journal-title":"Cancers"},{"key":"4206_CR48","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s00011-016-0995-1","volume":"66","author":"H Su","year":"2017","unstructured":"Su H, Na N, Zhang X et al (2017) The biological function and significance of CD74 in immune diseases. Inflamm Res 66:209\u2013216. https:\/\/doi.org\/10.1007\/s00011-016-0995-1","journal-title":"Inflamm Res"},{"key":"4206_CR49","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1186\/s12974-020-02038-2","volume":"17","author":"E Sigfridsson","year":"2020","unstructured":"Sigfridsson E, Marangoni M, Hardingham GE et al (2020) Deficiency of Nrf2 exacerbates white matter damage and microglia\/macrophage levels in a mouse model of vascular cognitive impairment. J Neuroinflammation 17:367. https:\/\/doi.org\/10.1186\/s12974-020-02038-2","journal-title":"J Neuroinflammation"},{"key":"4206_CR50","doi-asserted-by":"publisher","first-page":"e12928","DOI":"10.1111\/bpa.12928","volume":"31","author":"R Waller","year":"2021","unstructured":"Waller R, Narramore R, Simpson JE et al (2021) Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer\u2019s and small vessel disease pathologies. Brain Pathol 31:e12928. https:\/\/doi.org\/10.1111\/bpa.12928","journal-title":"Brain Pathol"},{"key":"4206_CR51","doi-asserted-by":"publisher","first-page":"4148","DOI":"10.3892\/mmr.2017.6525","volume":"15","author":"IK Hwang","year":"2017","unstructured":"Hwang IK, Park JH, Lee TK et al (2017) CD74-immunoreactive activated M1 microglia are shown late in the gerbil hippocampal CA1 region following transient cerebral ischemia. Mol Med Rep 15:4148\u20134154. https:\/\/doi.org\/10.3892\/mmr.2017.6525","journal-title":"Mol Med Rep"},{"key":"4206_CR52","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.2174\/1389557515666150203144111","volume":"14","author":"R Bucala","year":"2014","unstructured":"Bucala R, Shachar I (2014) The integral role of CD74 in antigen presentation, MIF signal transduction, and B cell survival and homeostasis. Mini Rev Med Chem 14:1132\u20131138. https:\/\/doi.org\/10.2174\/1389557515666150203144111","journal-title":"Mini Rev Med Chem"},{"key":"4206_CR53","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1073\/pnas.1612195114","volume":"114","author":"N Gil-Yarom","year":"2017","unstructured":"Gil-Yarom N, Radomir L, Sever L et al (2017) CD74 is a novel transcription regulator. Proc Natl Acad Sci U S A 114:562\u2013567. https:\/\/doi.org\/10.1073\/pnas.1612195114","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4206_CR54","doi-asserted-by":"publisher","first-page":"2752","DOI":"10.3389\/fimmu.2019.02752","volume":"10","author":"AM Abu El-Asrar","year":"2019","unstructured":"Abu El-Asrar AM, Ahmad A, Siddiquei MM et al (2019) The proinflammatory and proangiogenic macrophage migration inhibitory factor is a potential regulator in proliferative diabetic retinopathy. Front Immunol 10:2752. https:\/\/doi.org\/10.3389\/fimmu.2019.02752","journal-title":"Front Immunol"},{"key":"4206_CR55","doi-asserted-by":"publisher","first-page":"956078","DOI":"10.3389\/fimmu.2022.956078","volume":"13","author":"J Wang","year":"2022","unstructured":"Wang J, Kang Z, Liu Y et al (2022) Identification of immune cell infiltration and diagnostic biomarkers in unstable atherosclerotic plaques by integrated bioinformatics analysis and machine learning. Front Immunol 13:956078. https:\/\/doi.org\/10.3389\/fimmu.2022.956078","journal-title":"Front Immunol"},{"key":"4206_CR56","doi-asserted-by":"publisher","first-page":"e2205417119","DOI":"10.1073\/pnas.2205417119","volume":"119","author":"AJ Kwiatkowski","year":"2022","unstructured":"Kwiatkowski AJ, Helm EY, Stewart JM et al (2022) Treatment with an antigen-specific dual microparticle system reverses advanced multiple sclerosis in mice. Proc Natl Acad Sci U S A 119:e2205417119. https:\/\/doi.org\/10.1073\/pnas.2205417119","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4206_CR57","doi-asserted-by":"publisher","first-page":"111606","DOI":"10.1016\/j.celrep.2022.111606","volume":"41","author":"C Guo","year":"2022","unstructured":"Guo C, Liu Q, Zong D et al (2022) Single-cell transcriptome profiling and chromatin accessibility reveal an exhausted regulatory CD4\u2009+\u2009T cell subset in systemic lupus erythematosus. Cell Rep 41:111606. https:\/\/doi.org\/10.1016\/j.celrep.2022.111606","journal-title":"Cell Rep"},{"key":"4206_CR58","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s13075-018-1603-2","volume":"20","author":"B H\u00fcgle","year":"2018","unstructured":"H\u00fcgle B, Schippers A, Fischer N et al (2018) Transcription factor motif enrichment in whole transcriptome analysis identifies STAT4 and BCL6 as the most prominent binding motif in systemic juvenile idiopathic arthritis. Arthritis Res Ther 20:98. https:\/\/doi.org\/10.1186\/s13075-018-1603-2","journal-title":"Arthritis Res Ther"},{"key":"4206_CR59","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1136\/annrheumdis-2020-219803","volume":"80","author":"DJ Wallace","year":"2021","unstructured":"Wallace DJ, Figueras F, Wegener WA et al (2021) Experience with milatuzumab, an anti-CD74 antibody against immunomodulatory macrophage migration inhibitory factor (MIF) receptor, for systemic lupus erythematosus (SLE). Ann Rheum Dis 80:954\u2013955. https:\/\/doi.org\/10.1136\/annrheumdis-2020-219803","journal-title":"Ann Rheum Dis"},{"key":"4206_CR60","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.immuni.2017.08.008","volume":"47","author":"S Krasemann","year":"2017","unstructured":"Krasemann S, Madore C, Cialic R et al (2017) The TREM2-APOE pathway drives the transcriptional phenotype of dysfunctional microglia in neurodegenerative diseases. Immunity 47:566\u2013581. https:\/\/doi.org\/10.1016\/j.immuni.2017.08.008","journal-title":"Immunity"},{"key":"4206_CR61","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1002\/alz.12256","volume":"17","author":"M Audrain","year":"2021","unstructured":"Audrain M, Haure-Mirande JV, Mleczko J et al (2021) Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer\u2019s-related mice. Alzheimers Dement 17:149\u2013163. https:\/\/doi.org\/10.1002\/alz.12256","journal-title":"Alzheimers Dement"},{"key":"4206_CR62","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.yexcr.2016.06.019","volume":"346","author":"A Mishra","year":"2016","unstructured":"Mishra A, Iyer S, Kesarwani A et al (2016) Role of antigen presenting cell invariant chain in the development of hepatic steatosis in mouse model. Exp Cell Res 346:188\u2013197. https:\/\/doi.org\/10.1016\/j.yexcr.2016.06.019","journal-title":"Exp Cell Res"},{"key":"4206_CR63","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s12016-019-08726-z","volume":"58","author":"MT Bozza","year":"2020","unstructured":"Bozza MT, Lintomen L, Kitoko JZ et al (2020) The role of MIF on eosinophil biology and eosinophilic inflammation. Clin Rev Allergy Immunol 58:15\u201324. https:\/\/doi.org\/10.1007\/s12016-019-08726-z","journal-title":"Clin Rev Allergy Immunol"},{"key":"4206_CR64","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1593\/neo.132034","volume":"16","author":"G Zhu","year":"2014","unstructured":"Zhu G, Tang Y, Geng N et al (2014) HIF-\u03b1\/MIF and NF-\u03baB\/IL-6 axes contribute to the recruitment of CD11b\u2009+\u2009Gr-1\u2009+\u2009myeloid cells in hypoxic microenvironment of HNSCC. Neoplasia 16:168\u2013179. https:\/\/doi.org\/10.1593\/neo.132034","journal-title":"Neoplasia"},{"key":"4206_CR65","doi-asserted-by":"publisher","first-page":"10274","DOI":"10.3390\/ijms231810247","volume":"23","author":"J Jahn","year":"2022","unstructured":"Jahn J, Bollensdorf A, Kalischer C et al (2022) Microglial CD74 expression is regulated by TGF\u03b2 signaling. Int J Mol Sci 23:10274. https:\/\/doi.org\/10.3390\/ijms231810247","journal-title":"Int J Mol Sci"},{"key":"4206_CR66","doi-asserted-by":"publisher","first-page":"e2200061","DOI":"10.1002\/bimj.202200061","volume":"65","author":"SK Piper","year":"2023","unstructured":"Piper SK, Zocholl D, Toelch U et al (2023) Statistical review of animal trials-A guideline. Biom J 65:e2200061. https:\/\/doi.org\/10.1002\/bimj.202200061","journal-title":"Biom J"},{"key":"4206_CR67","doi-asserted-by":"publisher","first-page":"155119","DOI":"10.1016\/j.phymed.2023.155119","volume":"121","author":"SP Lin","year":"2023","unstructured":"Lin SP, Zhu L, Shi H et al (2023) Puerarin prevents sepsis-associated encephalopathy by regulating the AKT1 pathway in microglia. Phytomedicine 121:155119. https:\/\/doi.org\/10.1016\/j.phymed.2023.155119","journal-title":"Phytomedicine"},{"key":"4206_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15548627.2023.2286116","volume":"22","author":"K Pierzynowska","year":"2023","unstructured":"Pierzynowska K, Podlacha M, Gaffke L et al (2023) Correction of symptoms of Huntington disease by genistein through FOXO3-mediated autophagy stimulation. Autophagy 22:1\u201324. https:\/\/doi.org\/10.1080\/15548627.2023.2286116","journal-title":"Autophagy"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-024-04206-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-024-04206-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-024-04206-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T13:14:16Z","timestamp":1725110056000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-024-04206-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,16]]},"references-count":68,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["4206"],"URL":"https:\/\/doi.org\/10.1007\/s11064-024-04206-9","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,16]]},"assertion":[{"value":"22 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 May 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 July 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Laboratory Animal Welfare and Ethics Committee of Third Military Medical University (Ethical Approval Number: AMUWEC20210186). The operating processes were conducted in compliance with relevant guidelines of the National Institutes of Health on the Care and Use of Animals as well as the ARRIVE (Animal Research: Reporting in vivo Experiments).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}