{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T08:13:43Z","timestamp":1789028023180,"version":"build-2803163510"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100010883","name":"Administration of Traditional Chinese Medicine of Guangdong Province","doi-asserted-by":"crossref","award":["20231117"],"award-info":[{"award-number":["20231117"]}],"id":[{"id":"10.13039\/501100010883","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangdong Provincial Key Laboratory of Research on Emergency in TCM","award":["2023B1212060062"],"award-info":[{"award-number":["2023B1212060062"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2021M700906"],"award-info":[{"award-number":["2021M700906"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Scientific Research Foundation of Guangdong Province","award":["A2022239"],"award-info":[{"award-number":["A2022239"]}]},{"name":"special project of Science and Technology of Traditional Chinese Medicine of Guangdong Provincial Hospital of Chinese Medicine","award":["YN2020QN23"],"award-info":[{"award-number":["YN2020QN23"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1007\/s11064-024-04228-3","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T09:58:18Z","timestamp":1724320698000},"page":"3105-3117","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pre-electroacupuncture Ameliorates Cerebral Ischemia-reperfusion Injury by Inhibiting Microglial RhoA\/pyrin\/GSDMD Signaling Pathway"],"prefix":"10.1007","volume":"49","author":[{"given":"Hao","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Ling","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Ling","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye-Feng","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jun","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,21]]},"reference":[{"issue":"1","key":"4228_CR1","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/s41572-019-0118-8","volume":"5","author":"BCV Campbell","year":"2019","unstructured":"Campbell BCV, De Silva D-A, Macleod M-R et al (2019) Ischaemic stroke[J]. Nat Rev Dis Primers 5(1):70","journal-title":"Nat Rev Dis Primers"},{"issue":"9735","key":"4228_CR2","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/S0140-6736(10)60834-3","volume":"376","author":"M-J O\u2019Donnell","year":"2010","unstructured":"O\u2019Donnell M-J, Xavier D, Liu L et al (2010) Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study[J]. Lancet 376(9735):112\u2013123","journal-title":"Lancet"},{"key":"4228_CR3","doi-asserted-by":"crossref","unstructured":"Moretti A, Ferrari F, Villa R-F (2015) Pharmacological therapy of acute ischaemic stroke: achievements and problems[J]. Pharmacol Ther, 15379\u201315389","DOI":"10.1016\/j.pharmthera.2015.06.004"},{"key":"4228_CR4","doi-asserted-by":"crossref","unstructured":"Cai L, Yao Z-Y, Yang L et al (2022) Mechanism of Electroacupuncture Against Cerebral Ischemia-Reperfusion Injury: reducing inflammatory response and cell pyroptosis by inhibiting NLRP3 and Caspase-1[J]. Front Mol Neurosci, 15822088","DOI":"10.3389\/fnmol.2022.822088"},{"issue":"3","key":"4228_CR5","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/s12264-022-00977-9","volume":"39","author":"D Yao","year":"2023","unstructured":"Yao D, Zhang R, Xie M et al (2023) Updated understanding of the glial-vascular unit in Central Nervous System Disorders[J]. Neurosci Bull 39(3):503\u2013518","journal-title":"Neurosci Bull"},{"issue":"11","key":"4228_CR6","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.1161\/STROKEAHA.112.659656","volume":"43","author":"P X Hu, Li","year":"2012","unstructured":"X Hu, Li P, Guo Y et al (2012) Microglia\/macrophage polarization dynamics reveal novel mechanism of injury expansion after focal cerebral ischemia[J]. Stroke 43(11):3063\u20133070","journal-title":"Stroke"},{"issue":"Pt B","key":"4228_CR7","doi-asserted-by":"publisher","first-page":"116990","DOI":"10.1016\/j.jep.2023.116990","volume":"318","author":"C Zhou","year":"2024","unstructured":"Zhou C, Li J-X, Zheng C-X et al (2024) Neuroprotective effects of Jie-Du-Huo-Xue decoction on microglia pyroptosis after cerebral ischemia and reperfusion\u2013from the perspective of glial-vascular unit[J]. J Ethnopharmacol 318(Pt B):116990","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"4228_CR8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","volume":"20","author":"P Broz","year":"2020","unstructured":"Broz P, Pelegrin P, Shao F (2020) The gasdermins, a protein family executing cell death and inflammation[J]. Nat Rev Immunol 20(3):143\u2013157","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"4228_CR9","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12974-023-02819-5","volume":"20","author":"J Li","year":"2023","unstructured":"Li J, Xu P, Hong Y et al (2023) Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia\/reperfusion injury[J]. J Neuroinflammation 20(1):148","journal-title":"J Neuroinflammation"},{"key":"4228_CR10","doi-asserted-by":"crossref","unstructured":"Cai W, Wu Z, Lai J et al (2023) LDC7559 inhibits microglial activation and GSDMD-dependent pyroptosis after subarachnoid hemorrhage[J]. Front Immunol, 141117310","DOI":"10.3389\/fimmu.2023.1117310"},{"issue":"8","key":"4228_CR11","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1038\/nrm.2016.67","volume":"17","author":"R-G Hodge","year":"2016","unstructured":"Hodge R-G, Ridley A-J (2016) Regulating rho GTPases and their regulators[J]. Nat Rev Mol Cell Biol 17(8):496\u2013510","journal-title":"Nat Rev Mol Cell Biol"},{"key":"4228_CR12","doi-asserted-by":"crossref","unstructured":"Lu W, Chen Z, Wen J (2023) The role of RhoA\/ROCK pathway in the ischemic stroke-induced neuroinflammation[J]. Biomed Pharmacother, 165115141","DOI":"10.1016\/j.biopha.2023.115141"},{"key":"4228_CR13","doi-asserted-by":"crossref","unstructured":"Glotfelty E-J, Tovar-Y-Romo L-B, Hsueh S-C et al (2023) The RhoA-ROCK1\/ROCK2 pathway exacerbates Inflammatory Signaling in Immortalized and primary Microglia[J]. Cells, 12(10)","DOI":"10.3390\/cells12101367"},{"key":"4228_CR14","doi-asserted-by":"crossref","unstructured":"Wang J, Ni G, Liu Y et al (2020) Tanshinone IIA promotes axonal regeneration in rats with focal cerebral ischemia through the inhibition of Nogo-A\/NgR1\/RhoA\/ROCKII\/MLC Signaling[J]. Drug Des Devel Ther, pp 142775\u2013142787","DOI":"10.2147\/DDDT.S253280"},{"issue":"7517","key":"4228_CR15","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1038\/nature13449","volume":"513","author":"H Xu","year":"2014","unstructured":"Xu H, Yang J, Gao W et al (2014) Innate immune sensing of bacterial modifications of rho GTPases by the pyrin inflammasome[J]. Nature 513(7517):237\u2013241","journal-title":"Nature"},{"issue":"8","key":"4228_CR16","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1038\/ni.3457","volume":"17","author":"Y-H Park","year":"2016","unstructured":"Park Y-H, Wood G, Kastner D-L et al (2016) Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS[J]. Nat Immunol 17(8):914\u2013921","journal-title":"Nat Immunol"},{"key":"4228_CR17","doi-asserted-by":"crossref","unstructured":"Schnappauf O, Chae J-J, Kastner D-L et al (2019) The pyrin inflammasome in Health and Disease[J]. Front Immunol, 101745","DOI":"10.3389\/fimmu.2019.01745"},{"key":"4228_CR18","doi-asserted-by":"crossref","unstructured":"Ding H, Cheng Q, Fang X et al (2023) Dihydromyricetin Alleviates Ischemic Brain Injury by Antagonizing Pyroptosis in Rats[J]. Neurotherapeutics","DOI":"10.1007\/s13311-023-01425-w"},{"key":"4228_CR19","doi-asserted-by":"crossref","unstructured":"Ran Y, Su W, Gao F et al (2021) Curcumin ameliorates White Matter Injury after ischemic stroke by inhibiting Microglia\/Macrophage pyroptosis through NF-kappaB suppression and NLRP3 inflammasome Inhibition[J]. Oxid Med Cell Longev, 20211552127","DOI":"10.1155\/2021\/1552127"},{"issue":"6","key":"4228_CR20","first-page":"625","volume":"49","author":"J Zhou","year":"2024","unstructured":"Zhou J, Fu Y-B, Song Y-Q et al (2024) Progress of researches on mechanisms of acupuncture for secondary prevention of ischemic stroke[J]. Zhen Ci Yan Jiu 49(6):625\u2013633","journal-title":"Zhen Ci Yan Jiu"},{"issue":"4","key":"4228_CR21","first-page":"496","volume":"15","author":"H Zhang","year":"2023","unstructured":"Zhang H, Jin B, You X et al (2023) Pharmacodynamic advantages and characteristics of traditional Chinese medicine in prevention and treatment of ischemic stroke[J]. Chin Herb Med 15(4):496\u2013508","journal-title":"Chin Herb Med"},{"issue":"5","key":"4228_CR22","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1001\/jamaoncol.2021.0310","volume":"7","author":"J-J Mao","year":"2021","unstructured":"Mao J-J, Liou K-T, Baser R-E et al (2021) Effectiveness of electroacupuncture or auricular acupuncture vs Usual Care for Chronic Musculoskeletal Pain among Cancer survivors: the PEACE Randomized Clinical Trial[J]. JAMA Oncol 7(5):720\u2013727","journal-title":"JAMA Oncol"},{"issue":"21","key":"4228_CR23","doi-asserted-by":"publisher","first-page":"2755","DOI":"10.1001\/jama.284.21.2755","volume":"284","author":"J Shen","year":"2000","unstructured":"Shen J, Wenger N, Glaspy J et al (2000) Electroacupuncture for control of myeloablative chemotherapy-induced emesis: a randomized controlled trial[J]. JAMA 284(21):2755\u20132761","journal-title":"JAMA"},{"issue":"7","key":"4228_CR24","doi-asserted-by":"publisher","first-page":"e2220563","DOI":"10.1001\/jamanetworkopen.2022.20563","volume":"5","author":"X Yin","year":"2022","unstructured":"Yin X, Li W, Liang T et al (2022) Effect of electroacupuncture on Insomnia in patients with Depression: a randomized clinical Trial[J]. JAMA Netw Open 5(7):e2220563","journal-title":"JAMA Netw Open"},{"issue":"24","key":"4228_CR25","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1001\/jama.2017.7220","volume":"317","author":"Z Liu","year":"2017","unstructured":"Liu Z, Liu Y, Xu H et al (2017) Effect of electroacupuncture on urinary leakage among women with stress urinary incontinence: a randomized clinical Trial[J]. JAMA 317(24):2493\u20132501","journal-title":"JAMA"},{"key":"4228_CR26","doi-asserted-by":"crossref","unstructured":"Zhang Z-J, Man S-C, Yam L-L et al (2020) Electroacupuncture trigeminal nerve stimulation plus body acupuncture for chemotherapy-induced cognitive impairment in breast cancer patients: an assessor-participant blinded, randomized controlled trial[J]. Brain Behav Immun, 8888\u20138896","DOI":"10.1016\/j.bbi.2020.04.035"},{"key":"4228_CR27","doi-asserted-by":"crossref","unstructured":"Ma Z, Zhang Z, Bai F et al (2019) Electroacupuncture pretreatment alleviates cerebral ischemic Injury through alpha7 nicotinic acetylcholine receptor-mediated phenotypic Conversion of Microglia[J]. Front Cell Neurosci, 13537","DOI":"10.3389\/fncel.2019.00537"},{"issue":"13","key":"4228_CR28","doi-asserted-by":"publisher","first-page":"13187","DOI":"10.18632\/aging.103420","volume":"12","author":"Z-G Mei","year":"2020","unstructured":"Mei Z-G, Huang Y-G, Feng Z-T et al (2020) Electroacupuncture ameliorates cerebral ischemia\/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway[J]. Aging 12(13):13187\u201313205","journal-title":"Aging"},{"issue":"9","key":"4228_CR29","doi-asserted-by":"publisher","first-page":"2295","DOI":"10.1177\/0271678X21994395","volume":"41","author":"C Yang","year":"2021","unstructured":"Yang C, Liu J, Wang J et al (2021) Activation of astroglial CB1R mediates cerebral ischemic tolerance induced by electroacupuncture[J]. J Cereb Blood Flow Metab 41(9):2295\u20132310","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"4228_CR30","first-page":"833","volume":"39","author":"P Young-Wook","year":"2019","unstructured":"Young-Wook P, Min Jae-K GY-H et al (2019) Subacute electroacupuncture at Baihui (GV 20) and Dazhui (GV 14) promotes post-stroke functional recovery via neurogenesis and astrogliosis in a photothrombotic stroke mouse model[J]. J Tradit Chin Med 39(6):833\u2013841","journal-title":"J Tradit Chin Med"},{"issue":"5","key":"4228_CR31","first-page":"402","volume":"45","author":"S-M Zheng","year":"2020","unstructured":"Zheng S-M, Zhao F-L, Luo Y-Y et al (2020) [Clinical effect of electroacupuncture at Baihui and Shuigou points in treatment of brain injury in patients with sepsis-associated encephalopathy][J]. Zhen Ci Yan Jiu 45(5):402\u2013406","journal-title":"Zhen Ci Yan Jiu"},{"issue":"4","key":"4228_CR32","first-page":"375","volume":"40","author":"K-P Xia","year":"2020","unstructured":"Xia K-P, Pang J, Li S-L et al (2020) [Effect of electroacupuncture at governor vessel on learning-memory ability and serum level of APP, Abeta(1\u201342) in patients with Alzheimer\u2019s disease][J]. Zhongguo Zhen Jiu 40(4):375\u2013378","journal-title":"Zhongguo Zhen Jiu"},{"issue":"6","key":"4228_CR33","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.4103\/1673-5374.300454","volume":"16","author":"H-L Wang","year":"2021","unstructured":"Wang H-L, Liu F-L, Li R-Q et al (2021) Electroacupuncture improves learning and memory functions in a rat cerebral ischemia\/reperfusion injury model through PI3K\/Akt signaling pathway activation[J]. Neural Regen Res 16(6):1011\u20131016","journal-title":"Neural Regen Res"},{"key":"4228_CR34","doi-asserted-by":"crossref","unstructured":"Pang F, Yang Y, Huang S et al (2023) Electroacupuncture alleviates depressive-like behavior by modulating the expression of P2X7\/NLRP3\/IL-1beta of Prefrontal Cortex and liver in rats exposed to chronic unpredictable mild Stress[J]. Brain Sci, 13(3)","DOI":"10.3390\/brainsci13030436"},{"issue":"3","key":"4228_CR35","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.jad.2010.07.007","volume":"128","author":"Q Liu","year":"2011","unstructured":"Liu Q, Li B, Zhu H-Y et al (2011) Glia atrophy in the hippocampus of chronic unpredictable stress-induced depression model rats is reversed by electroacupuncture treatment[J]. J Affect Disord 128(3):309\u2013313","journal-title":"J Affect Disord"},{"key":"4228_CR36","doi-asserted-by":"crossref","unstructured":"Chavez L-M, Huang S-S, MacDonald I et al (2017) Mechanisms of acupuncture therapy in Ischemic Stroke Rehabilitation: A literature review of Basic Studies[J]. Int J Mol Sci, 18(11)","DOI":"10.3390\/ijms18112270"},{"issue":"11","key":"4228_CR37","first-page":"941","volume":"47","author":"H-Y Zhang","year":"2022","unstructured":"Zhang H-Y, Zhao Y-J, Zhang P-J et al (2022) [Acupuncture ameliorates neurological function by suppressing microglia polarization and inflammatory response after cerebral ischemia in rats][J]. Zhen Ci Yan Jiu 47(11):941\u2013948","journal-title":"Zhen Ci Yan Jiu"},{"issue":"2","key":"4228_CR38","doi-asserted-by":"publisher","first-page":"e90000","DOI":"10.1371\/journal.pone.0090000","volume":"9","author":"Y-R Kim","year":"2014","unstructured":"Kim Y-R, Kim H-N, Ahn S-M et al (2014) Electroacupuncture promotes post-stroke functional recovery via enhancing endogenous neurogenesis in mouse focal cerebral ischemia[J]. PLoS ONE 9(2):e90000","journal-title":"PLoS ONE"},{"key":"4228_CR39","doi-asserted-by":"crossref","unstructured":"Jung Y-S, Lee S-W, Park J-H et al (2016) Electroacupuncture preconditioning reduces ROS generation with NOX4 down-regulation and ameliorates blood-brain barrier disruption after ischemic stroke[J]. J Biomed Sci, 2332","DOI":"10.1186\/s12929-016-0249-0"},{"issue":"1","key":"4228_CR40","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","volume":"20","author":"E-Z Longa","year":"1989","unstructured":"Longa E-Z, Weinstein P-R, Carlson S et al (1989) Reversible middle cerebral artery occlusion without craniectomy in rats[J]. Stroke 20(1):84\u201391","journal-title":"Stroke"},{"key":"4228_CR41","doi-asserted-by":"crossref","unstructured":"Eldahshan W, Fagan S-C, Ergul A (2019) Inflammation within the neurovascular unit: focus on microglia for stroke injury and recovery[J]. Pharmacol Res, 147104349","DOI":"10.1016\/j.phrs.2019.104349"},{"issue":"1","key":"4228_CR42","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1002\/med.21817","volume":"42","author":"Q-Z Tuo","year":"2022","unstructured":"Tuo Q-Z, Zhang S-T, Lei P (2022) Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications[J]. Med Res Rev 42(1):259\u2013305","journal-title":"Med Res Rev"},{"issue":"1","key":"4228_CR43","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1186\/s12974-019-1603-4","volume":"16","author":"F Jing","year":"2019","unstructured":"Jing F, Zhang Y, Long T et al (2019) P2Y12 receptor mediates microglial activation via RhoA\/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine[J]. J Neuroinflammation 16(1):217","journal-title":"J Neuroinflammation"},{"issue":"4","key":"4228_CR44","doi-asserted-by":"publisher","first-page":"e13587","DOI":"10.1111\/acel.13587","volume":"21","author":"Z Zhu","year":"2022","unstructured":"Zhu Z, Lu J, Wang S et al (2022) Acrolein, an endogenous aldehyde induces synaptic dysfunction in vitro and in vivo: involvement of RhoA\/ROCK2 pathway[J]. Aging Cell 21(4):e13587","journal-title":"Aging Cell"},{"key":"4228_CR45","doi-asserted-by":"crossref","unstructured":"Li L, Wang Q, Sun X et al (2023) Activation of RhoA pathway participated in the changes of emotion, cognitive function and hippocampal synaptic plasticity in juvenile chronic stress rats[J]. Int J Biol Macromol, 233123652","DOI":"10.1016\/j.ijbiomac.2023.123652"},{"issue":"4","key":"4228_CR46","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/S1474-4422(09)70054-7","volume":"8","author":"U Dirnagl","year":"2009","unstructured":"Dirnagl U, Becker K, Meisel A (2009) Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use[J]. Lancet Neurol 8(4):398\u2013412","journal-title":"Lancet Neurol"},{"key":"4228_CR47","unstructured":"Wang ML, Shao Z (2022) L, Electroacupuncture pretreatment attenuates cerebral ischemia-reperfusion Injury in rats through transient receptor potential vanilloid 1-Mediated anti-apoptosis via inhibiting NF-kappaB signaling Pathway[J]. Neuroscience, 482100\u2013482115"},{"issue":"1","key":"4228_CR48","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nrneurol.2014.207","volume":"11","author":"X Hu","year":"2015","unstructured":"Hu X, Leak R-K, Shi Y et al (2015) Microglial and macrophage polarization-new prospects for brain repair[J]. Nat Rev Neurol 11(1):56\u201364","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"4228_CR49","doi-asserted-by":"publisher","first-page":"6","DOI":"10.4103\/1673-5374.286954","volume":"16","author":"W Zhang","year":"2021","unstructured":"Zhang W, Tian T, Gong S-X et al (2021) Microglia-associated neuroinflammation is a potential therapeutic target for ischemic stroke[J]. Neural Regen Res 16(1):6\u201311","journal-title":"Neural Regen Res"},{"key":"4228_CR50","doi-asserted-by":"crossref","unstructured":"Yang X, Xu S, Qian Y et al (2017) Resveratrol regulates microglia M1\/M2 polarization via PGC-1alpha in conditions of neuroinflammatory injury[J]. Brain Behav Immun, 64162\u201364172","DOI":"10.1016\/j.bbi.2017.03.003"},{"issue":"12","key":"4228_CR51","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/nri2873","volume":"10","author":"G-Y Chen","year":"2010","unstructured":"Chen G-Y, Nunez G (2010) Sterile inflammation: sensing and reacting to damage[J]. Nat Rev Immunol 10(12):826\u2013837","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"4228_CR52","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nm.3893","volume":"21","author":"H Guo","year":"2015","unstructured":"Guo H, Callaway J-B, Ting J-P (2015) Inflammasomes: mechanism of action, role in disease, and therapeutics[J]. Nat Med 21(7):677\u2013687","journal-title":"Nat Med"},{"key":"4228_CR53","doi-asserted-by":"crossref","unstructured":"Wang J-L, Hua S-N, Bao H-J et al (2020) Pyroptosis and inflammasomes in cancer and inflammation[J]. MedComm 2023, 4(5): e374","DOI":"10.1002\/mco2.374"},{"key":"4228_CR54","doi-asserted-by":"crossref","unstructured":"Liu C, Zhou Y, Tu Q et al (2023) Alpha-linolenic acid pretreatment alleviates NETs-induced alveolar macrophage pyroptosis by inhibiting pyrin inflammasome activation in a mouse model of sepsis-induced ALI\/ARDS[J]. Front Immunol, 141146612","DOI":"10.3389\/fimmu.2023.1146612"},{"issue":"7","key":"4228_CR55","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1038\/gene.2011.53","volume":"12","author":"S Grandemange","year":"2011","unstructured":"Grandemange S, Aksentijevich I, Jeru I et al (2011) The regulation of MEFV expression and its role in health and familial Mediterranean fever[J]. Genes Immun 12(7):497\u2013503","journal-title":"Genes Immun"},{"key":"4228_CR56","doi-asserted-by":"crossref","unstructured":"Stankiewicz T-R, Linseman D-A (2014) Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration[J]. Front Cell Neurosci, 8314","DOI":"10.3389\/fncel.2014.00314"},{"key":"4228_CR57","doi-asserted-by":"crossref","unstructured":"Pavon M-V, Navakkode S, Wong L-W et al (2023) Inhibition of Nogo-A rescues synaptic plasticity and associativity in APP\/PS1 animal model of Alzheimer\u2019s disease[J]. Semin Cell Dev Biol, 139111\u2013139120","DOI":"10.1016\/j.semcdb.2022.04.005"},{"issue":"1","key":"4228_CR58","doi-asserted-by":"publisher","first-page":"e12660","DOI":"10.1111\/jpi.12660","volume":"69","author":"Y Xu","year":"2020","unstructured":"Xu Y, Cui K, Li J et al (2020) Melatonin attenuates choroidal neovascularization by regulating macrophage\/microglia polarization via inhibition of RhoA\/ROCK signaling pathway[J]. J Pineal Res 69(1):e12660","journal-title":"J Pineal Res"},{"key":"4228_CR59","doi-asserted-by":"crossref","unstructured":"Zhang Y, Miao L, Peng Q et al (2022) Parthenolide modulates cerebral ischemia-induced microglial polarization and alleviates neuroinflammatory injury via the RhoA\/ROCK pathway[J]. Phytomedicine, 105154373","DOI":"10.1016\/j.phymed.2022.154373"},{"issue":"8","key":"4228_CR60","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.1161\/01.STR.0000231647.41578.df","volume":"37","author":"S Chrissobolis","year":"2006","unstructured":"Chrissobolis S, Sobey C-G (2006) Recent evidence for an involvement of rho-kinase in cerebral vascular disease[J]. Stroke 37(8):2174\u20132180","journal-title":"Stroke"},{"issue":"10","key":"4228_CR61","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/s41419-023-06217-w","volume":"14","author":"R Socodato","year":"2023","unstructured":"Socodato R, Rodrigues-Santos A, Tedim-Moreira J et al (2023) RhoA balances microglial reactivity and survival during neuroinflammation[J]. Cell Death Dis 14(10):690","journal-title":"Cell Death Dis"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-024-04228-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-024-04228-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-024-04228-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T08:08:29Z","timestamp":1727942909000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-024-04228-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,21]]},"references-count":61,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["4228"],"URL":"https:\/\/doi.org\/10.1007\/s11064-024-04228-3","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,21]]},"assertion":[{"value":"26 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 August 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}