{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:16:12Z","timestamp":1780082172994,"version":"3.54.0"},"reference-count":95,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T00:00:00Z","timestamp":1726185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s11064-024-04240-7","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T18:02:22Z","timestamp":1726250542000},"page":"3326-3341","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Mirtazapine Improves Locomotor Activity and Attenuates Neuropathic Pain Following Spinal Cord Injury in Rats via Neuroinflammation Modulation"],"prefix":"10.1007","volume":"49","author":[{"given":"Seyed Hadi","family":"Aghili","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Amin","family":"Manavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Panji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehri","family":"Farhang Ranjbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramin","family":"Abrishami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Reza","family":"Dehpour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,13]]},"reference":[{"issue":"12","key":"4240_CR1","first-page":"3827","volume":"109","author":"J Sun","year":"2023","unstructured":"Sun J et al (2023) Traumatic spinal injury-related hospitalizations in the United States, 2016\u20132019: a retrospective study. Int J Surg 109(12):3827\u20133835","journal-title":"Int J Surg"},{"issue":"11","key":"4240_CR2","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/S1474-4422(23)00287-9","volume":"22","author":"GBD Spinal Cord Injuries Collaborators","year":"2023","unstructured":"GBD Spinal Cord Injuries Collaborators (2023) Global, regional, and national burden of spinal cord injury, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol 22(11):1026\u20131047","journal-title":"Lancet Neurol"},{"key":"4240_CR3","doi-asserted-by":"crossref","unstructured":"Kifley A et al  (2023) Complex lived experiences and hidden disability after spinal cord injury: a latent profile analysis of the Australian arm of the International Spinal Cord Injury (Aus-InSCI) Community Survey. Disabil Rehabil, pp 1\u201312","DOI":"10.1080\/09638288.2023.2283101"},{"issue":"1","key":"4240_CR4","doi-asserted-by":"publisher","first-page":"119","DOI":"10.5535\/arm.2012.36.1.119","volume":"36","author":"JC Shin","year":"2012","unstructured":"Shin JC et al (2012) Depression and quality of life in patients within the first 6 months after the spinal cord injury. Ann Rehabil Med 36(1):119\u2013125","journal-title":"Ann Rehabil Med"},{"issue":"5","key":"4240_CR5","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/s41393-019-0402-1","volume":"58","author":"J Li","year":"2020","unstructured":"Li J, Reinhardt JD, Feng X (2020) Physical function, post-traumatic stress disorder, and quality of life in persons with spinal cord injury caused by the Wenchuan earthquake versus nondisaster trauma: a cross-sectional modeling study. Spinal Cord 58(5):616\u2013625","journal-title":"Spinal Cord"},{"issue":"5","key":"4240_CR6","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1097\/HRP.0000000000000340","volume":"30","author":"M Yousefifard","year":"2022","unstructured":"Yousefifard M et al (2022) Prevalence of posttraumatic stress disorder symptoms following traumatic spinal cord injury: a systematic review and meta-analysis. Harv Rev Psychiatry 30(5):271\u2013282","journal-title":"Harv Rev Psychiatry"},{"issue":"23\u201324","key":"4240_CR7","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.1089\/neu.2023.0200","volume":"40","author":"CH Bombardier","year":"2023","unstructured":"Bombardier CH et al (2023) Collaborative care versus usual care to improve quality of life, pain, depression, and physical activity in outpatients with spinal cord injury: the SCI-CARE randomized controlled clinical trial. J Neurotrauma 40(23\u201324):2667\u20132679","journal-title":"J Neurotrauma"},{"issue":"1","key":"4240_CR8","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/sc.2012.51","volume":"51","author":"E Atao\u011flu","year":"2013","unstructured":"Atao\u011flu E et al (2013) Effects of chronic pain on quality of life and depression in patients with spinal cord injury. Spinal Cord 51(1):23\u201326","journal-title":"Spinal Cord"},{"issue":"6","key":"4240_CR9","first-page":"463","volume":"37","author":"L Guha","year":"2023","unstructured":"Guha L, Kumar H (2023) drug repurposing for spinal cord injury: progress towards therapeutic intervention for primary factors and secondary complications. Pharmaceut Med 37(6):463\u2013490","journal-title":"Pharmaceut Med"},{"key":"4240_CR10","doi-asserted-by":"crossref","unstructured":"Anjum A et al (2020) Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms. Int J Mol Sci 21(20).","DOI":"10.3390\/ijms21207533"},{"issue":"11","key":"4240_CR11","doi-asserted-by":"publisher","first-page":"4574","DOI":"10.1093\/brain\/awad221","volume":"146","author":"N Delestr\u00e9e","year":"2023","unstructured":"Delestr\u00e9e N et al (2023) Serotonergic dysfunction impairs locomotor coordination in spinal muscular atrophy. Brain 146(11):4574\u20134593","journal-title":"Brain"},{"key":"4240_CR12","doi-asserted-by":"crossref","unstructured":"Koivisto A et al (2018) TRPA1 Antagonists for Pain Relief. Pharmaceuticals (Basel) 11(4).","DOI":"10.3390\/ph11040117"},{"key":"4240_CR13","doi-asserted-by":"crossref","unstructured":"Freyermuth-Trujillo X et al (2022) Inflammation: a target for treatment in spinal cord injury. Cells 11(17).","DOI":"10.3390\/cells11172692"},{"key":"4240_CR14","doi-asserted-by":"crossref","unstructured":"Veneruso V et al (2023) Synergistic pharmacological therapy to modulate glial cells in spinal cord injury. Adv Mater, pp e2307747.","DOI":"10.1016\/j.ibneur.2023.08.455"},{"key":"4240_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2022.102145","volume":"125","author":"R Guo","year":"2022","unstructured":"Guo R et al (2022) Ulinastatin attenuates spinal cord injury by targeting AMPK\/NLRP3 signaling pathway. J Chem Neuroanat 125:102145","journal-title":"J Chem Neuroanat"},{"issue":"1","key":"4240_CR16","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1186\/s13018-023-03902-6","volume":"18","author":"JH Zheng","year":"2023","unstructured":"Zheng JH et al (2023) Acupuncture combined with moxibustion mitigates spinal cord injury-induced motor dysfunction in mice by NLRP3-IL-18 signaling pathway inhibition. J Orthop Surg Res 18(1):419","journal-title":"J Orthop Surg Res"},{"issue":"1","key":"4240_CR17","doi-asserted-by":"publisher","first-page":"20698","DOI":"10.1038\/s41598-020-77652-4","volume":"10","author":"R Kikuoka","year":"2020","unstructured":"Kikuoka R et al (2020) Mirtazapine exerts astrocyte-mediated dopaminergic neuroprotection. Sci Rep 10(1):20698","journal-title":"Sci Rep"},{"issue":"5","key":"4240_CR18","doi-asserted-by":"publisher","first-page":"2603","DOI":"10.1007\/s00210-023-02818-6","volume":"397","author":"EHM Hassanein","year":"2023","unstructured":"Hassanein EHM et al (2023) Pharmacological update of mirtazapine: a narrative literature review. Naunyn Schmiedebergs Arch Pharmacol 397(5):2603\u20132619","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"5","key":"4240_CR19","doi-asserted-by":"publisher","first-page":"427","DOI":"10.2165\/00023210-200923050-00006","volume":"23","author":"KF Croom","year":"2009","unstructured":"Croom KF, Perry CM, Plosker GL (2009) Mirtazapine: a review of its use in major depression and other psychiatric disorders. CNS Drugs 23(5):427\u2013452","journal-title":"CNS Drugs"},{"key":"4240_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114553","volume":"161","author":"R Abdelhady","year":"2023","unstructured":"Abdelhady R et al (2023) Mirtazapine, an atypical antidepressant, mitigates lung fibrosis by suppressing NLPR3 inflammasome and fibrosis-related mediators in endotracheal bleomycin rat model. Biomed Pharmacother 161:114553","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"4240_CR21","doi-asserted-by":"publisher","first-page":"3680","DOI":"10.1080\/21655979.2021.2024962","volume":"13","author":"Y Pu","year":"2022","unstructured":"Pu Y et al (2022) The protective effects of Mirtazapine against lipopolysaccharide (LPS)-induced brain vascular hyperpermeability. Bioengineered 13(2):3680\u20133693","journal-title":"Bioengineered"},{"key":"4240_CR22","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1016\/j.biopha.2017.09.022","volume":"95","author":"AE El-Sisi","year":"2017","unstructured":"El-Sisi AE, El-Sayad ME, Abdelsalam NM (2017) Protective effects of mirtazapine and chrysin on experimentally induced testicular damage in rats. Biomed Pharmacother 95:1059\u20131066","journal-title":"Biomed Pharmacother"},{"issue":"8","key":"4240_CR23","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1080\/15376516.2023.2231530","volume":"33","author":"SA Alharthy","year":"2023","unstructured":"Alharthy SA et al (2023) Mirtazapine attenuated cadmium-induced neuronal intoxication by regulating Nrf2 and NF-\u03baB\/TLR4 signals. Toxicol Mech Methods 33(8):675\u2013687","journal-title":"Toxicol Mech Methods"},{"issue":"3","key":"4240_CR24","first-page":"217","volume":"16","author":"FS Kilic","year":"2011","unstructured":"Kilic FS et al (2011) The acute effects of mirtazapine on pain related behavior in healthy animals. Neurosciences (Riyadh) 16(3):217\u2013223","journal-title":"Neurosciences (Riyadh)"},{"issue":"2","key":"4240_CR25","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.neuropharm.2004.09.012","volume":"48","author":"SF Bomholt","year":"2005","unstructured":"Bomholt SF, Mikkelsen JD, Blackburn-Munro G (2005) Antinociceptive effects of the antidepressants amitriptyline, duloxetine, mirtazapine and citalopram in animal models of acute, persistent and neuropathic pain. Neuropharmacology 48(2):252\u2013263","journal-title":"Neuropharmacology"},{"issue":"8","key":"4240_CR26","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1038\/bjp.2008.353","volume":"155","author":"B Milne","year":"2008","unstructured":"Milne B et al (2008) Low doses of alpha 2-adrenoceptor antagonists augment spinal morphine analgesia and inhibit development of acute and chronic tolerance. Br J Pharmacol 155(8):1264\u20131278","journal-title":"Br J Pharmacol"},{"issue":"6","key":"4240_CR27","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1080\/01616412.2019.1580462","volume":"41","author":"E Bektur","year":"2019","unstructured":"Bektur E et al (2019) Beneficial effect of mirtazapine on diabetes-induced hyperalgesia: involvement of TRPV1 and ASIC1 channels in the spinal cord and dorsal root ganglion. Neurol Res 41(6):544\u2013553","journal-title":"Neurol Res"},{"issue":"2","key":"4240_CR28","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/sj.npp.1300057","volume":"28","author":"GJ Marek","year":"2003","unstructured":"Marek GJ et al (2003) Synergistic action of 5-HT2A antagonists and selective serotonin reuptake inhibitors in neuropsychiatric disorders. Neuropsychopharmacology 28(2):402\u2013412","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"4240_CR29","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.pain.2007.08.014","volume":"137","author":"J Van Steenwinckel","year":"2008","unstructured":"Van Steenwinckel J et al (2008) Role of spinal serotonin 5-HT2A receptor in 2\u2019,3\u2019-dideoxycytidine-induced neuropathic pain in the rat and the mouse. Pain 137(1):66\u201380","journal-title":"Pain"},{"key":"4240_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2021.113667","volume":"419","author":"TQ Oliveira","year":"2022","unstructured":"Oliveira TQ et al (2022) Lipoic acid prevents mirtazapine-induced weight gain in mice without impairs its antidepressant-like action in a neuroendocrine model of depression. Behav Brain Res 419:113667","journal-title":"Behav Brain Res"},{"issue":"1","key":"4240_CR31","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.neulet.2007.12.037","volume":"433","author":"J Zhu","year":"2008","unstructured":"Zhu J et al (2008) Repeated administration of mirtazapine inhibits development of hyperalgesia\/allodynia and activation of NF-kappaB in a rat model of neuropathic pain. Neurosci Lett 433(1):33\u201337","journal-title":"Neurosci Lett"},{"issue":"Pt A","key":"4240_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108174","volume":"101","author":"HM Hafez","year":"2021","unstructured":"Hafez HM et al (2021) Protective effect of mirtazapine against acetic acid-induced ulcerative colitis in rats: Role of NLRP3 inflammasome pathway. Int Immunopharmacol 101(Pt A):108174","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"4240_CR33","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.acthis.2019.01.007","volume":"121","author":"E Sahin","year":"2019","unstructured":"Sahin E et al (2019) Mirtazapine suppresses sterile inflammation through NLRP3-inflammasome in diabetic rat kidney. Acta Histochem 121(3):289\u2013296","journal-title":"Acta Histochem"},{"key":"4240_CR34","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.phrs.2017.04.028","volume":"121","author":"E Alcocer-G\u00f3mez","year":"2017","unstructured":"Alcocer-G\u00f3mez E et al (2017) Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder. Pharmacol Res 121:114\u2013121","journal-title":"Pharmacol Res"},{"issue":"2","key":"4240_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2020.e03414","volume":"6","author":"I Sultan","year":"2020","unstructured":"Sultan I et al (2020) The safety and efficacy of steroid treatment for acute spinal cord injury: a systematic review and meta-analysis. Heliyon 6(2):e03414","journal-title":"Heliyon"},{"key":"4240_CR36","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.taap.2017.06.012","volume":"329","author":"DM El-Tanbouly","year":"2017","unstructured":"El-Tanbouly DM, Wadie W, Sayed RH (2017) Modulation of TGF-\u03b2\/Smad and ERK signaling pathways mediates the anti-fibrotic effect of mirtazapine in mice. Toxicol Appl Pharmacol 329:224\u2013230","journal-title":"Toxicol Appl Pharmacol"},{"issue":"1","key":"4240_CR37","doi-asserted-by":"publisher","first-page":"61","DOI":"10.11607\/jop.1105","volume":"28","author":"K Nakai","year":"2014","unstructured":"Nakai K et al (2014) Antinociceptive effects of mirtazapine, pregabalin, and gabapentin after chronic constriction injury of the infraorbital nerve in rats. J Oral Facial Pain Headache 28(1):61\u201367","journal-title":"J Oral Facial Pain Headache"},{"key":"4240_CR38","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ynpai.2017.04.002","volume":"1","author":"H Ueda","year":"2017","unstructured":"Ueda H, Neyama H (2017) LPA1 receptor involvement in fibromyalgia-like pain induced by intermittent psychological stress, empathy. Neurobiol Pain 1:16\u201325","journal-title":"Neurobiol Pain"},{"key":"4240_CR39","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1471-2202-15-79","volume":"15","author":"N Kadoguchi","year":"2014","unstructured":"Kadoguchi N et al (2014) Mirtazapine has a therapeutic potency in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mice model of Parkinson\u2019s disease. BMC Neurosci 15:79","journal-title":"BMC Neurosci"},{"issue":"9","key":"4240_CR40","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1007\/s11064-013-1103-3","volume":"38","author":"X Liu","year":"2013","unstructured":"Liu X et al (2013) Repeated administration of mirtazapine attenuates oxaliplatin-induced mechanical allodynia and spinal NR2B up-regulation in rats. Neurochem Res 38(9):1973\u20131979","journal-title":"Neurochem Res"},{"issue":"5","key":"4240_CR41","doi-asserted-by":"publisher","first-page":"389","DOI":"10.2165\/00023210-199605050-00007","volume":"5","author":"R Davis","year":"1996","unstructured":"Davis R, Wilde MI (1996) Mirtazapine: a review of its pharmacology and therapeutic potential in the management of major depression. CNS Drugs 5(5):389\u2013402","journal-title":"CNS Drugs"},{"key":"4240_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106743","volume":"86","author":"K Moradi","year":"2020","unstructured":"Moradi K et al (2020) Inhibition of phosphodiesterase IV enzyme improves locomotor and sensory complications of spinal cord injury via altering microglial activity: introduction of Roflumilast as an alternative therapy. Int Immunopharmacol 86:106743","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"4240_CR43","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1080\/01616412.2020.1819090","volume":"43","author":"K Afshari","year":"2021","unstructured":"Afshari K et al (2021) Sumatriptan improves the locomotor activity and neuropathic pain by modulating neuroinflammation in rat model of spinal cord injury. Neurol Res 43(1):29\u201339","journal-title":"Neurol Res"},{"issue":"5","key":"4240_CR44","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1055\/s-0041-1735854","volume":"83","author":"A Rismanbaf","year":"2022","unstructured":"Rismanbaf A et al (2022) Therapeutic effects of azithromycin on spinal cord injury in male wistar rats: a role for inflammatory pathways. J Neurol Surg A Cent Eur Neurosurg 83(5):411\u2013419","journal-title":"J Neurol Surg A Cent Eur Neurosurg"},{"key":"4240_CR45","doi-asserted-by":"crossref","unstructured":"Rismanbaf A et al (2022) Aripiprazole improves spinal cord injury in rats: involvement of inflammatory pathways. Acta Medica Iran, 60.","DOI":"10.18502\/acta.v60i9.11100"},{"issue":"6","key":"4240_CR46","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/S0361-9230(02)00825-0","volume":"58","author":"S Schreiber","year":"2002","unstructured":"Schreiber S et al (2002) The antinociceptive effect of mirtazapine in mice is mediated through serotonergic, noradrenergic and opioid mechanisms. Brain Res Bull 58(6):601\u2013605","journal-title":"Brain Res Bull"},{"issue":"1","key":"4240_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/neu.1995.12.1","volume":"12","author":"DM Basso","year":"1995","unstructured":"Basso DM, Beattie MS, Bresnahan JC (1995) A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12(1):1\u201321","journal-title":"J Neurotrauma"},{"issue":"8","key":"4240_CR48","doi-asserted-by":"publisher","first-page":"6575","DOI":"10.1002\/jcb.26777","volume":"119","author":"H Babaei","year":"2018","unstructured":"Babaei H et al (2018) Increased circulation mobilization of endothelial progenitor cells in preterm infants with retinopathy of prematurity. J Cell Biochem 119(8):6575\u20136583","journal-title":"J Cell Biochem"},{"key":"4240_CR49","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.mvr.2018.02.005","volume":"118","author":"M Jabarpour","year":"2018","unstructured":"Jabarpour M et al (2018) Hyperbilirubinemia-induced pro-angiogenic activity of infantile endothelial progenitor cells. Microvasc Res 118:49\u201356","journal-title":"Microvasc Res"},{"issue":"8","key":"4240_CR50","doi-asserted-by":"publisher","first-page":"1934","DOI":"10.1002\/jcb.25492","volume":"117","author":"V Siavashi","year":"2016","unstructured":"Siavashi V et al (2016) ECM-dependence of endothelial progenitor cell features. J Cell Biochem 117(8):1934\u20131946","journal-title":"J Cell Biochem"},{"issue":"3","key":"4240_CR51","doi-asserted-by":"publisher","first-page":"412","DOI":"10.4103\/0975-7406.84454","volume":"3","author":"P Sikka","year":"2011","unstructured":"Sikka P et al (2011) Study of antinociceptive activity of SSRI (fluoxetine and escitalopram) and atypical antidepressants (venlafaxine and mirtazepine) and their interaction with morphine and naloxone in mice. J Pharm Bioallied Sci 3(3):412\u2013416","journal-title":"J Pharm Bioallied Sci"},{"key":"4240_CR52","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.176267","volume":"964","author":"X Fan","year":"2024","unstructured":"Fan X et al (2024) Neuroprotective effects of tetramethylpyrazine on spinal cord injury-related neuroinflammation mediated by P2X7R\/NLRP3 interaction. Eur J Pharmacol 964:176267","journal-title":"Eur J Pharmacol"},{"key":"4240_CR53","doi-asserted-by":"publisher","first-page":"174480692110662","DOI":"10.1177\/17448069211066221","volume":"17","author":"S Kartha","year":"2021","unstructured":"Kartha S, Ghimire P, Winkelstein BA (2021) Inhibiting spinal secretory phospholipase A(2) after painful nerve root injury attenuates established pain and spinal neuronal hyperexcitability by altering spinal glutamatergic signaling. Mol Pain 17:17448069211066220","journal-title":"Mol Pain"},{"issue":"1","key":"4240_CR54","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/s12974-021-02337-2","volume":"18","author":"DJ Hellenbrand","year":"2021","unstructured":"Hellenbrand DJ et al (2021) Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration. J Neuroinflammation 18(1):284","journal-title":"J Neuroinflammation"},{"issue":"9","key":"4240_CR55","doi-asserted-by":"publisher","first-page":"6484","DOI":"10.1007\/s12035-024-03979-y","volume":"61","author":"J Zhong","year":"2024","unstructured":"Zhong J et al (2024) Low-dose LPS modulates microglia\/macrophages phenotypic transformation to amplify rehabilitation effects in chronic spinal cord injured (CSCI) mice. Mol Neurobiol 61(9):6484\u20136500","journal-title":"Mol Neurobiol"},{"key":"4240_CR56","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.intimp.2019.02.006","volume":"70","author":"R Lv","year":"2019","unstructured":"Lv R et al (2019) Polydatin alleviates traumatic spinal cord injury by reducing microglial inflammation via regulation of iNOS and NLRP3 inflammasome pathway. Int Immunopharmacol 70:28\u201336","journal-title":"Int Immunopharmacol"},{"key":"4240_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2020.103497","volume":"105","author":"PA Rocha","year":"2020","unstructured":"Rocha PA et al (2020) Effects of selective inhibition of nNOS and iNOS on neuropathic pain in rats. Mol Cell Neurosci 105:103497","journal-title":"Mol Cell Neurosci"},{"key":"4240_CR58","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.993168","volume":"13","author":"F Jiang","year":"2022","unstructured":"Jiang F et al (2022) Cannabinoid receptor-2 attenuates neuroinflammation by promoting autophagy-mediated degradation of the NLRP3 inflammasome post spinal cord injury. Front Immunol 13:993168","journal-title":"Front Immunol"},{"issue":"1","key":"4240_CR59","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1021\/acschemneuro.3c00596","volume":"15","author":"T Mokhtari","year":"2024","unstructured":"Mokhtari T, Uludag K (2024) Role of NLRP3 inflammasome in post-spinal-cord-injury anxiety and depression: molecular mechanisms and therapeutic implications. ACS Chem Neurosci 15(1):56\u201370","journal-title":"ACS Chem Neurosci"},{"key":"4240_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110103","volume":"118","author":"Z Liu","year":"2023","unstructured":"Liu Z et al (2023) Hesperetin ameliorates spinal cord injury by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling. Int Immunopharmacol 118:110103","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"4240_CR61","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1002\/ejp.905","volume":"21","author":"D Burke","year":"2017","unstructured":"Burke D et al (2017) Neuropathic pain prevalence following spinal cord injury: a systematic review and meta-analysis. Eur J Pain 21(1):29\u201344","journal-title":"Eur J Pain"},{"issue":"16","key":"4240_CR62","doi-asserted-by":"publisher","first-page":"4308","DOI":"10.1523\/JNEUROSCI.0003-06.2006","volume":"26","author":"BC Hains","year":"2006","unstructured":"Hains BC, Waxman SG (2006) Activated microglia contribute to the maintenance of chronic pain after spinal cord injury. J Neurosci 26(16):4308\u20134317","journal-title":"J Neurosci"},{"key":"4240_CR63","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.expneurol.2014.02.001","volume":"258","author":"ET Walters","year":"2014","unstructured":"Walters ET (2014) Neuroinflammatory contributions to pain after SCI: roles for central glial mechanisms and nociceptor-mediated host defense. Exp Neurol 258:48\u201361","journal-title":"Exp Neurol"},{"issue":"8","key":"4240_CR64","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/S0166-2236(00)01854-3","volume":"24","author":"LR Watkins","year":"2001","unstructured":"Watkins LR, Milligan ED, Maier SF (2001) Glial activation: a driving force for pathological pain. Trends Neurosci 24(8):450\u2013455","journal-title":"Trends Neurosci"},{"issue":"1","key":"4240_CR65","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1186\/s13041-022-00970-3","volume":"15","author":"N Gu","year":"2022","unstructured":"Gu N et al (2022) Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity. Mol Brain 15(1):86","journal-title":"Mol Brain"},{"issue":"3\u20134","key":"4240_CR66","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1177\/09727531211046367","volume":"28","author":"GS Miranpuri","year":"2021","unstructured":"Miranpuri GS et al (2021) Role of microglia and astrocytes in spinal cord injury induced neuropathic pain. Ann Neurosci 28(3\u20134):219\u2013228","journal-title":"Ann Neurosci"},{"key":"4240_CR67","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2020.104827","volume":"140","author":"CT Huang","year":"2020","unstructured":"Huang CT et al (2020) Melatonin reduces neuropathic pain behavior and glial activation through MT(2) melatonin receptor modulation in a rat model of lysophosphatidylcholine-induced demyelination neuropathy. Neurochem Int 140:104827","journal-title":"Neurochem Int"},{"issue":"3","key":"4240_CR68","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s11481-013-9449-5","volume":"8","author":"F Begum","year":"2013","unstructured":"Begum F et al (2013) Elevation of tumor necrosis factor \u03b1 in dorsal root ganglia and spinal cord is associated with neuroimmune modulation of pain in an animal model of multiple sclerosis. J Neuroimmune Pharmacol 8(3):677\u2013690","journal-title":"J Neuroimmune Pharmacol"},{"key":"4240_CR69","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.expneurol.2014.02.013","volume":"255","author":"MR Detloff","year":"2014","unstructured":"Detloff MR et al (2014) Acute exercise prevents the development of neuropathic pain and the sprouting of non-peptidergic (GDNF- and artemin-responsive) c-fibers after spinal cord injury. Exp Neurol 255:38\u201348","journal-title":"Exp Neurol"},{"key":"4240_CR70","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.neulet.2016.02.005","volume":"617","author":"S Forner","year":"2016","unstructured":"Forner S et al (2016) Neuropathic pain induced by spinal cord injury: Role of endothelin ETA and ETB receptors. Neurosci Lett 617:14\u201321","journal-title":"Neurosci Lett"},{"issue":"3","key":"4240_CR71","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1089\/neu.2011.2059","volume":"29","author":"CY Lin","year":"2012","unstructured":"Lin CY et al (2012) Fibronectin inhibits chronic pain development after spinal cord injury. J Neurotrauma 29(3):589\u2013599","journal-title":"J Neurotrauma"},{"key":"4240_CR72","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.578654","volume":"11","author":"RP Davis","year":"2020","unstructured":"Davis RP et al (2020) The antidepressant mirtazapine activates hepatic macrophages, facilitating pathogen clearance while limiting tissue damage in mice. Front Immunol 11:578654","journal-title":"Front Immunol"},{"issue":"1","key":"4240_CR73","doi-asserted-by":"publisher","first-page":"12","DOI":"10.5152\/npa.2015.8791","volume":"53","author":"A Inal","year":"2016","unstructured":"Inal A, B\u00fcy\u00fck\u015fekerci M, Ulusoy HB (2016) Antinociceptive effect of mirtazapine in rats with diabetic neuropathy. Noro Psikiyatr Ars 53(1):12\u201316","journal-title":"Noro Psikiyatr Ars"},{"issue":"2","key":"4240_CR74","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1097\/AJP.0b013e318159f94a","volume":"24","author":"P Arnold","year":"2008","unstructured":"Arnold P et al (2008) Mirtazapine decreases the pain feeling in healthy participants. Clin J Pain 24(2):116\u2013119","journal-title":"Clin J Pain"},{"issue":"6","key":"4240_CR75","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1002\/syn.21532","volume":"66","author":"T Enomoto","year":"2012","unstructured":"Enomoto T et al (2012) Effects of mirtazapine on sleep disturbance under neuropathic pain-like state. Synapse 66(6):483\u2013488","journal-title":"Synapse"},{"issue":"1","key":"4240_CR76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/jpet.120.265942","volume":"375","author":"H Neyama","year":"2020","unstructured":"Neyama H et al (2020) Mirtazapine, an \u03b12 antagonist-type antidepressant, reverses pain and lack of morphine analgesia in fibromyalgia-like mouse models. J Pharmacol Exp Ther 375(1):1\u20139","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"4240_CR77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0264386","volume":"17","author":"H Ito","year":"2022","unstructured":"Ito H et al (2022) Suvorexant and mirtazapine improve chronic pain-related changes in parameters of sleep and voluntary physical performance in mice with sciatic nerve ligation. PLoS ONE 17(2):e0264386","journal-title":"PLoS ONE"},{"issue":"12","key":"4240_CR78","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1007\/s00296-018-4068-3","volume":"38","author":"AA Ottman","year":"2018","unstructured":"Ottman AA, Warner CB, Brown JN (2018) The role of mirtazapine in patients with fibromyalgia: a systematic review. Rheumatol Int 38(12):2217\u20132224","journal-title":"Rheumatol Int"},{"issue":"11","key":"4240_CR79","first-page":"414","volume":"13","author":"J Prowting","year":"1985","unstructured":"Prowting J et al (1985) Mirtazapine reduces susceptibility to hypocapnic central sleep apnea in males with sleep-disordered breathing: a pilot study. J Appl Physiol 131(1): 414\u2013423.","journal-title":"J Appl Physiol"},{"issue":"11","key":"4240_CR80","doi-asserted-by":"publisher","first-page":"2901","DOI":"10.1016\/j.celrep.2016.11.047","volume":"17","author":"P Stemkowski","year":"2016","unstructured":"Stemkowski P et al (2016) TRPV1 nociceptor activity initiates USP5\/T-type channel-mediated plasticity. Cell Rep 17(11):2901\u20132912","journal-title":"Cell Rep"},{"key":"4240_CR81","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.neures.2020.12.007","volume":"170","author":"K Baba","year":"2021","unstructured":"Baba K et al (2021) Heat hypersensitivity is attenuated with altered expression level of spinal astrocytes after sciatic nerve injury in TRPV1 knockout mice. Neurosci Res 170:273\u2013283","journal-title":"Neurosci Res"},{"key":"4240_CR82","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/1744-8069-6-94","volume":"6","author":"K Mitchell","year":"2010","unstructured":"Mitchell K et al (2010) Ablation of rat TRPV1-expressing Adelta\/C-fibers with resiniferatoxin: analysis of withdrawal behaviors, recovery of function and molecular correlates. Mol Pain 6:94","journal-title":"Mol Pain"},{"issue":"4","key":"4240_CR83","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1002\/cne.20794","volume":"493","author":"K Kobayashi","year":"2005","unstructured":"Kobayashi K et al (2005) Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta\/c-fibers and colocalization with trk receptors. J Comp Neurol 493(4):596\u2013606","journal-title":"J Comp Neurol"},{"key":"4240_CR84","doi-asserted-by":"crossref","unstructured":"Fang  K et al (2023) Kilohertz high-frequency electrical stimulation ameliorate hyperalgesia by modulating TRPV1 and NMDAR2B signaling pathways in chronic constriction injury of sciatic nerve mice. Mol Pain, 17448069231225810.","DOI":"10.21203\/rs.3.rs-2604850\/v1"},{"key":"4240_CR85","doi-asserted-by":"publisher","first-page":"174480692110439","DOI":"10.1177\/17448069211043965","volume":"17","author":"L Heijmans","year":"2021","unstructured":"Heijmans L, Mons MR, Joosten EA (2021) A systematic review on descending serotonergic projections and modulation of spinal nociception in chronic neuropathic pain and after spinal cord stimulation. Mol Pain 17:17448069211043964","journal-title":"Mol Pain"},{"issue":"2","key":"4240_CR86","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1089\/neu.2005.22.203","volume":"22","author":"DD Fuller","year":"2005","unstructured":"Fuller DD et al (2005) Cervical spinal cord injury upregulates ventral spinal 5-HT2A receptors. J Neurotrauma 22(2):203\u2013213","journal-title":"J Neurotrauma"},{"key":"4240_CR87","doi-asserted-by":"crossref","unstructured":"Andersen MS et al (2022) The development of hindlimb postural asymmetry induced by focal traumatic brain injury is not related to Serotonin 2A\/C receptor expression in the spinal cord. Int J Mol Sci, 23(10).","DOI":"10.3390\/ijms23105358"},{"issue":"1","key":"4240_CR88","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/bju.13964","volume":"121","author":"N Cao","year":"2018","unstructured":"Cao N et al (2018) Chronic spinal cord injury causes upregulation of serotonin (5-HT)(2A) and 5-HT(2C) receptors in lumbosacral cord motoneurons. BJU Int 121(1):145\u2013154","journal-title":"BJU Int"},{"issue":"1","key":"4240_CR89","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1073\/pnas.1213680110","volume":"110","author":"R Bos","year":"2013","unstructured":"Bos R et al (2013) Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A 110(1):348\u2013353","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4240_CR90","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.neuropharm.2018.09.028","volume":"143","author":"R Patel","year":"2018","unstructured":"Patel R, Dickenson AH (2018) Modality selective roles of pro-nociceptive spinal 5-HT(2A) and 5-HT(3) receptors in normal and neuropathic states. Neuropharmacology 143:29\u201337","journal-title":"Neuropharmacology"},{"issue":"3","key":"4240_CR91","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/S0165-0327(98)00223-7","volume":"51","author":"N Haddjeri","year":"1998","unstructured":"Haddjeri N, Blier P, de Montigny C (1998) Acute and long-term actions of the antidepressant drug mirtazapine on central 5-HT neurotransmission. J Affect Disord 51(3):255\u2013266","journal-title":"J Affect Disord"},{"key":"4240_CR92","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.neuroscience.2017.08.033","volume":"387","author":"I S\u00e1nchez-Brualla","year":"2018","unstructured":"S\u00e1nchez-Brualla I et al (2018) Activation of 5-HT(2A) receptors restores KCC2 function and reduces neuropathic pain after spinal cord injury. Neuroscience 387:48\u201357","journal-title":"Neuroscience"},{"issue":"4","key":"4240_CR93","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1213\/01.ANE.0000050560.15341.A8","volume":"96","author":"M Sasaki","year":"2003","unstructured":"Sasaki M et al (2003) Antinociception with intrathecal alpha-methyl-5-hydroxytryptamine, a 5-hydroxytryptamine 2A\/2C receptor agonist, in two rat models of sustained pain. Anesth Analg 96(4):1072\u20131078","journal-title":"Anesth Analg"},{"issue":"1","key":"4240_CR94","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1124\/jpet.111.183780","volume":"339","author":"PN Yadav","year":"2011","unstructured":"Yadav PN et al (2011) Antagonist functional selectivity: 5-HT2A serotonin receptor antagonists differentially regulate 5-HT2A receptor protein level in vivo. J Pharmacol Exp Ther 339(1):99\u2013105","journal-title":"J Pharmacol Exp Ther"},{"key":"4240_CR95","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.resp.2017.07.003","volume":"244","author":"KZ Lee","year":"2017","unstructured":"Lee KZ, Gonzalez-Rothi EJ (2017) Contribution of 5-HT(2A) receptors on diaphragmatic recovery after chronic cervical spinal cord injury. Respir Physiol Neurobiol 244:51\u201355","journal-title":"Respir Physiol Neurobiol"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-024-04240-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-024-04240-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-024-04240-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T09:06:41Z","timestamp":1729760801000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-024-04240-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,13]]},"references-count":95,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["4240"],"URL":"https:\/\/doi.org\/10.1007\/s11064-024-04240-7","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,13]]},"assertion":[{"value":"1 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 September 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 September 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interests"}},{"value":"The Ethics Committees of the Directorate of Health, Rescue and Treatment of Police Headquarters of the Islamic Republic of Iran and Shahid Beheshti University of Medical Sciences approved the study protocol (IR.SBMU.TEB.POLICE.REC.1402.034).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}}]}}