{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:43:42Z","timestamp":1775709822490,"version":"3.50.1"},"reference-count":76,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T00:00:00Z","timestamp":1731888000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100020970","name":"Rashtriya Uchchatar Shiksha Abhiyan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s11064-024-04285-8","type":"journal-article","created":{"date-parts":[[2024,11,18]],"date-time":"2024-11-18T09:43:29Z","timestamp":1731923009000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["AMP-Activated Protein Kinase Treatment Ameliorates Chronic Restraint Stress Induced Memory Impairment in Early Adolescent Rat by Restoring Metabolite Profile and Synaptic Proteins"],"prefix":"10.1007","volume":"50","author":[{"given":"Koilmani Emmanuvel","family":"Rajan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baskaran","family":"Nishanthini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swamynathan","family":"Sowndharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"4285_CR1","doi-asserted-by":"publisher","first-page":"903782","DOI":"10.3389\/fnbeh.2022.903782","volume":"16","author":"I Maita","year":"2022","unstructured":"Maita I, Roepke TA, Samuels BA (2022) Chronic stress-induced synaptic changes to corticotropin-releasing factor-signaling in the bed nucleus of the stria terminalis. Front Behav Neurosci 16:903782. https:\/\/doi.org\/10.3389\/fnbeh.2022.903782","journal-title":"Front Behav Neurosci"},{"issue":"6","key":"4285_CR2","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.1007\/s10753-021-01514-y","volume":"44","author":"HL Yang","year":"2021","unstructured":"Yang HL, Li MM, Zhou MF, Xu HS, Huan F, Liu N, Gao R, Wang J, Zhang N, Jiang L (2021) Links between gut dysbiosis and neurotransmitter disturbance in Chronic Restraint stress-Induced Depressive behaviours: the role of inflammation. Inflammation 44(6):2448\u20132462. https:\/\/doi.org\/10.1007\/s10753-021-01514-y","journal-title":"Inflammation"},{"issue":"4","key":"4285_CR3","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/med.0000000000000176","volume":"22","author":"N Quijije","year":"2015","unstructured":"Quijije N (2015) Updates in the neuroendocrinology of stress and its clinical management. Curr Opin Endocrinol Diabetes Obes 22(4):319\u2013324. https:\/\/doi.org\/10.1097\/med.0000000000000176","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"4285_CR4","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.bbr.2016.03.005","volume":"305","author":"L Liu","year":"2016","unstructured":"Liu L, Zhou X, Zhang Y, Liu Y, Yang L, Pu J, Zhu D, Zhou C, Xie P (2016) The identification of metabolic disturbances in the prefrontal cortex of the chronic restraint stress rat model of depression. Behav Brain Res 305:148\u2013156. https:\/\/doi.org\/10.1016\/j.bbr.2016.03.005","journal-title":"Behav Brain Res"},{"issue":"1","key":"4285_CR5","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.tig.2022.08.005","volume":"39","author":"P Kreitmaier","year":"2023","unstructured":"Kreitmaier P, Katsoula G, Zeggini E (2023) Insights from multi-omics integration in complex disease primary tissues. Trends Genet 39(1):46\u201358. https:\/\/doi.org\/10.1016\/j.tig.2022.08.005","journal-title":"Trends Genet"},{"issue":"1","key":"4285_CR6","doi-asserted-by":"publisher","first-page":"2321610","DOI":"10.1080\/10253890.2024.2321610","volume":"27","author":"S Mengelkoch","year":"2024","unstructured":"Mengelkoch S, Gassen J, Lev-Ari S, Alley JC, Sch\u00fcssler-Fiorenza Rose SM, Snyder MP, Slavich GM (2024) Multi-omics in stress and health research: study designs that will drive the field forward. Stress 27(1):2321610. https:\/\/doi.org\/10.1080\/10253890.2024.2321610","journal-title":"Stress"},{"issue":"17","key":"4285_CR7","doi-asserted-by":"publisher","first-page":"2627","DOI":"10.1016\/j.febslet.2008.06.040","volume":"582","author":"Y Ni","year":"2008","unstructured":"Ni Y, Su M, Lin J, Wang X, Qiu Y, Zhao A, Chen T, Jia W (2008) Metabolic profiling reveals disorder of amino acid metabolism in four brain regions from a rat model of chronic unpredictable mild stress. FEBS Lett 582(17):2627\u20132636. https:\/\/doi.org\/10.1016\/j.febslet.2008.06.040","journal-title":"FEBS Lett"},{"key":"4285_CR8","doi-asserted-by":"publisher","first-page":"113407","DOI":"10.1016\/j.bbr.2021.113407","volume":"412","author":"L Fan","year":"2021","unstructured":"Fan L, Yang L, Li X, Teng T, Xiang Y, Liu X, Jiang Y, Zhu Y, Zhou X, Xie P (2021) Proteomic and metabolomic characterization of amygdala in chronic social defeat stress rats. Behav Brain Res 412:113407. https:\/\/doi.org\/10.1016\/j.bbr.2021.113407","journal-title":"Behav Brain Res"},{"issue":"6","key":"4285_CR9","doi-asserted-by":"publisher","first-page":"2080","DOI":"10.1021\/pr060412s","volume":"6","author":"CR Teague","year":"2007","unstructured":"Teague CR, Dhabhar FS, Barton RH, Beckwith-Hall B, Powell J, Cobain M, Singer B, McEwen BS, Lindon JC, Nicholson JK, Holmes E (2007) Metabonomic studies on the physiological effects of acute and chronic psychological stress in Sprague-Dawley rats. J Proteome Res 6(6):2080\u20132093. https:\/\/doi.org\/10.1021\/pr060412s","journal-title":"J Proteome Res"},{"issue":"1","key":"4285_CR10","doi-asserted-by":"publisher","first-page":"13218","DOI":"10.1038\/s41598-023-40498-7","volume":"13","author":"T Uchida","year":"2023","unstructured":"Uchida T, Sugiura Y, Sugiyama E, Maeda R, Tanaka KF, Suematsu M, Mimura M, Uchida H (2023) Metabolites for monitoring symptoms and predicting remission in patients with depression who received electroconvulsive therapy: a pilot study. Sci Rep 13(1):13218. https:\/\/doi.org\/10.1038\/s41598-023-40498-7","journal-title":"Sci Rep"},{"issue":"21","key":"4285_CR11","doi-asserted-by":"publisher","first-page":"7430","DOI":"10.3390\/molecules28217430","volume":"28","author":"M Liu","year":"2023","unstructured":"Liu M, Ma W, He Y, Sun Z, Yang J (2023) Recent progress in Mass Spectrometry-based metabolomics in Major Depressive Disorder Research. Molecules 28(21):7430. https:\/\/doi.org\/10.3390\/molecules28217430","journal-title":"Molecules"},{"key":"4285_CR12","doi-asserted-by":"publisher","first-page":"1219718","DOI":"10.3389\/fnagi.2023.1219718","volume":"15","author":"G Berezhnoy","year":"2023","unstructured":"Berezhnoy G, Laske C, Trautwein C (2023) Metabolomic profiling of CSF and blood serum elucidates general and sex-specific patterns for mild cognitive impairment and Alzheimer\u2019s disease patients. Front Aging Neurosci 15:1219718. https:\/\/doi.org\/10.3389\/fnagi.2023.1219718","journal-title":"Front Aging Neurosci"},{"issue":"8","key":"4285_CR13","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.1007\/s11064-024-04153-5","volume":"49","author":"AR Giniatullin","year":"2024","unstructured":"Giniatullin AR, Mukhutdinova KA, Petrov AM (2024) Mechanism of purinergic regulation of neurotransmission in Mouse Neuromuscular Junction: the role of Redox Signaling and lipid rafts. Neurochem Res 49(8):2021\u20132037. https:\/\/doi.org\/10.1007\/s11064-024-04153-5","journal-title":"Neurochem Res"},{"issue":"1","key":"4285_CR14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s41398-024-02744-y","volume":"14","author":"D Guhathakurta","year":"2024","unstructured":"Guhathakurta D, Petru\u0161kov\u00e1 A, Akda\u015f EY, Perell\u00f3-Amor\u00f3s B, Frischknecht R, Anni D, Weiss EM, Walter M, Fejtov\u00e1 A (2024) Hydroxynorketamine, but not ketamine, acts via \u03b17 nicotinic acetylcholine receptor to control presynaptic function and gene expression. Transl Psychiatry 14(1):47. https:\/\/doi.org\/10.1038\/s41398-024-02744-y","journal-title":"Transl Psychiatry"},{"key":"4285_CR15","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/j.neuroimage.2016.08.013","volume":"142","author":"J Grandjean","year":"2016","unstructured":"Grandjean J, Azzinnari D, Seuwen A, Sigrist H, Seifritz E, Pryce CR, Rudin M (2016) Chronic psychosocial stress in mice leads to changes in brain functional connectivity and metabolite levels comparable to human depression. NeuroImage 142:544\u2013552. https:\/\/doi.org\/10.1016\/j.neuroimage.2016.08.013","journal-title":"NeuroImage"},{"issue":"2","key":"4285_CR16","doi-asserted-by":"publisher","first-page":"e13062","DOI":"10.1111\/jne.13062","volume":"34","author":"AM Rasmusson","year":"2022","unstructured":"Rasmusson AM, Pineles SL, Brown KD, Pinna G (2022) A role for deficits in GABAergic neurosteroids and their metabolites with NMDA receptor antagonist activity in the pathophysiology of posttraumatic stress disorder. J Neuroendocrinol 34(2):e13062. https:\/\/doi.org\/10.1111\/jne.13062","journal-title":"J Neuroendocrinol"},{"issue":"1","key":"4285_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00221-009-2103-z","volume":"202","author":"P Morales","year":"2010","unstructured":"Morales P, Simola N, Bustamante D, Lisboa F, Fiedler J, Gebicke-Haerter PJ, Morelli M, Tasker RA, Herrera-Marschitz M (2010) Nicotinamide prevents the long-term effects of perinatal asphyxia on apoptosis, non-spatial working memory and anxiety in rats. Exp Brain Res 202(1):1\u201314. https:\/\/doi.org\/10.1007\/s00221-009-2103-z","journal-title":"Exp Brain Res"},{"issue":"3","key":"4285_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.20463\/jenb.2018.0022","volume":"22","author":"YH Leem","year":"2018","unstructured":"Leem YH, Chang H (2018) The ameliorating effect of exercise on long-term memory impairment and dendritic retraction via the mild activation of AMP-activated protein kinase in chronically stressed hippocampal CA1 neurons. J Exerc Nutr Biochem 22(3):35\u201341. https:\/\/doi.org\/10.20463\/jenb.2018.0022","journal-title":"J Exerc Nutr Biochem"},{"issue":"4","key":"4285_CR19","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1016\/j.cmet.2019.09.001","volume":"30","author":"S Lautrup","year":"2019","unstructured":"Lautrup S, Sinclair DA, Mattson MP, Fang EF (2019) NAD+ in Brain Aging and Neurodegenerative disorders. Cell Metab 30(4):630\u2013655. https:\/\/doi.org\/10.1016\/j.cmet.2019.09.001","journal-title":"Cell Metab"},{"key":"4285_CR20","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.jad.2024.03.017","volume":"354","author":"A Song","year":"2024","unstructured":"Song A, Cheng R, Jiang J, Qu H, Wu Z, Qian F, Shen S, Zhang L, Wang Z, Zhao W, Lou Y (2024) Antidepressant-like effects of hyperoside on chronic stress-induced depressive-like behaviors in mice: gut microbiota and short-chain fatty acids. J Affect Disord 354:356\u2013367. https:\/\/doi.org\/10.1016\/j.jad.2024.03.017","journal-title":"J Affect Disord"},{"key":"4285_CR21","doi-asserted-by":"publisher","first-page":"102229","DOI":"10.1016\/j.npep.2022.102229","volume":"92","author":"V Sheibani","year":"2022","unstructured":"Sheibani V, Rajizadeh MA, Bejeshk MA, Haghparast E, Nozari M, Esmaeili-Mahani S, Nezhadi A (2022) The effects of neurosteroid allopregnanolone on synaptic dysfunction in the hippocampus in experimental parkinsonism rats: an electrophysiological and molecular study. Neuropeptides 92:102229. https:\/\/doi.org\/10.1016\/j.npep.2022.102229","journal-title":"Neuropeptides"},{"issue":"1","key":"4285_CR22","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1152\/jn.00326.2023","volume":"131","author":"LM Riggs","year":"2024","unstructured":"Riggs LM, Pereira EFR, Thompson SM, Gould TD (2024) cAMP-dependent protein kinase signaling is required for (2R,6R)-hydroxynorketamine to potentiate hippocampal glutamatergic transmission. J Neurophysiol 131(1):64\u201374. https:\/\/doi.org\/10.1152\/jn.00326.2023","journal-title":"J Neurophysiol"},{"key":"4285_CR23","doi-asserted-by":"publisher","first-page":"113523","DOI":"10.1016\/j.bbr.2021.113523","volume":"416","author":"S Moreno-Mart\u00ednez","year":"2022","unstructured":"Moreno-Mart\u00ednez S, Tendilla-Beltr\u00e1n H, Sandoval V, Flores G, Terr\u00f3n JA (2022) Chronic restraint stress induces anxiety-like behavior and remodeling of dendritic spines in the central nucleus of the amygdala. Behav Brain Res 416:113523. https:\/\/doi.org\/10.1016\/j.bbr.2021.113523","journal-title":"Behav Brain Res"},{"issue":"4","key":"4285_CR24","doi-asserted-by":"publisher","first-page":"3003","DOI":"10.1111\/ejn.16089","volume":"58","author":"\u0395 Dandi","year":"2023","unstructured":"Dandi \u0395, Spandou E, Dalla C, Tata DA (2023) \u03a4he neuroprotective role of environmental enrichment against behavioral, morphological, neuroendocrine and molecular changes following chronic unpredictable mild stress: a systematic review. Eur J Neurosci 58(4):3003\u20133025. https:\/\/doi.org\/10.1111\/ejn.16089","journal-title":"Eur J Neurosci"},{"key":"4285_CR25","doi-asserted-by":"publisher","unstructured":"Porter GA, O\u2019Connor JC (2021) Chronic unpredictable stress alters Brain Tryptophan Metabolism and impairs Working Memory in mice without causing Depression-Like Behaviour. Neurol Neurobiol (Tallinn) 4(3). https:\/\/doi.org\/10.31487\/j.nnb.2021.03.03","DOI":"10.31487\/j.nnb.2021.03.03"},{"issue":"6","key":"4285_CR26","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/nrn2651","volume":"10","author":"B Roozendaal","year":"2009","unstructured":"Roozendaal B, McEwen BS, Chattarji S (2009) Stress, memory and the amygdala. Nat Rev Neurosci 10(6):423\u2013433. https:\/\/doi.org\/10.1038\/nrn2651","journal-title":"Nat Rev Neurosci"},{"key":"4285_CR27","doi-asserted-by":"publisher","first-page":"100447","DOI":"10.1016\/j.ynstr.2022.100447","volume":"18","author":"E McManus","year":"2022","unstructured":"McManus E, Haroon H, Duncan NW, Elliott R, Muhlert N (2022) The effects of stress across the lifespan on the brain, cognition and mental health: a UK biobank study. Neurobiol Stress 18:100447. https:\/\/doi.org\/10.1016\/j.ynstr.2022.100447","journal-title":"Neurobiol Stress"},{"issue":"12","key":"4285_CR28","doi-asserted-by":"publisher","first-page":"7118","DOI":"10.1038\/s41380-021-01262-3","volume":"26","author":"L Huang","year":"2021","unstructured":"Huang L, Chen Y, Jin S, Lin L, Duan S, Si K, Gong W, Julius Zhu J (2021) Organizational principles of amygdalar input-output neuronal circuits. Mol Psychiatry 26(12):7118\u20137129. https:\/\/doi.org\/10.1038\/s41380-021-01262-3","journal-title":"Mol Psychiatry"},{"issue":"5","key":"4285_CR29","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s00359-021-01505-2","volume":"207","author":"KE Rajan","year":"2021","unstructured":"Rajan KE (2021) Olfactory learning and memory in the greater short-nosed fruit bat Cynopterus sphinx: the influence of conspecifics distress calls. J Comp Physiol Neuroethol Sens Neural Behav Physiol 207(5):667\u2013679. https:\/\/doi.org\/10.1007\/s00359-021-01505-2","journal-title":"J Comp Physiol Neuroethol Sens Neural Behav Physiol"},{"key":"4285_CR30","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.neuroscience.2015.02.012","volume":"291","author":"MA Padival","year":"2015","unstructured":"Padival MA, Blume SR, Vantrease JE, Rosenkranz JA (2015) Qualitatively different effect of repeated stress during adolescence on principal neuron morphology across lateral and basal nuclei of the rat amygdala. Neuroscience 291:128\u2013145. https:\/\/doi.org\/10.1016\/j.neuroscience.2015.02.012","journal-title":"Neuroscience"},{"issue":"5","key":"4285_CR31","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3390\/cells10051095","volume":"10","author":"D Vi\u0161nji\u0107","year":"2021","unstructured":"Vi\u0161nji\u0107 D, Lali\u0107 H, Dembitz V, Tomi\u0107 B, Smoljo T (2021) AICAr, a widely used AMPK activator with important AMPK-Independent effects: a systematic review. Cells 10(5):1095. https:\/\/doi.org\/10.3390\/cells10051095","journal-title":"Cells"},{"issue":"3","key":"4285_CR32","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/j.1365-2826.2007.01643.x","volume":"20","author":"S Coyral-Castel","year":"2008","unstructured":"Coyral-Castel S, Tosca L, Ferreira G, Jeanpierre E, Rame C, Lomet D, Caraty A, Monget P, Chabrolle C, Dupont J (2008) The effect of AMP-activated kinase activation on gonadotrophin-releasing hormone secretion in GT1-7 cells and its potential role in hypothalamic regulation of the oestrous cyclicity in rats. J Neuroendocrinol 20(3):335\u2013346. https:\/\/doi.org\/10.1111\/j.1365-2826.2007.01643.x","journal-title":"J Neuroendocrinol"},{"issue":"4","key":"4285_CR33","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/s0149-7634(00)00014-2","volume":"24","author":"LP Spear","year":"2000","unstructured":"Spear LP (2000) The adolescent brain and age-related behavioral manifestations. Neurosci Biobehav Rev 24(4):417\u2013463. https:\/\/doi.org\/10.1016\/s0149-7634(00)00014-2","journal-title":"Neurosci Biobehav Rev"},{"key":"4285_CR34","doi-asserted-by":"publisher","first-page":"166","DOI":"10.3389\/fphar.2016.00166","volume":"7","author":"J Preethi","year":"2016","unstructured":"Preethi J, Singh HK, Rajan KE (2016) Possible involvement of standardized Bacopa monniera extract (CDRI-08) in epigenetic regulation of reelin and brain-derived neurotrophic factor to enhance memory. Front Pharmacol 7:166. https:\/\/doi.org\/10.3389\/fphar.2016.00166","journal-title":"Front Pharmacol"},{"key":"4285_CR35","doi-asserted-by":"publisher","first-page":"107178","DOI":"10.1016\/j.ntt.2023.107178","volume":"97","author":"A Kamaladevi","year":"2023","unstructured":"Kamaladevi A, Rajan KE (2023) Antibiotic treatment during post-natal reverses behavioural and molecular alterations in experimental meningitis survivor rat model. Neurotoxicol Teratol 97:107178. https:\/\/doi.org\/10.1016\/j.ntt.2023.107178","journal-title":"Neurotoxicol Teratol"},{"issue":"7","key":"4285_CR36","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1046\/j.1460-9568.2002.02188.x","volume":"16","author":"CK McIntyre","year":"2002","unstructured":"McIntyre CK, Hatfield T, McGaugh JL (2002) Amygdala norepinephrine levels after training predict inhibitory avoidance retention performance in rats. Eur J Neurosci 16(7):1223\u20131226. https:\/\/doi.org\/10.1046\/j.1460-9568.2002.02188.x","journal-title":"Eur J Neurosci"},{"key":"4285_CR37","doi-asserted-by":"publisher","unstructured":"McIntyre CK, Power AE, Roozendaal B, McGaugh JL (2003) Role of the basolateral amygdala in memory consolidation. Ann N Y Acad Sci 985. https:\/\/doi.org\/10.1111\/j.1749-6632.2003.tb07088.x.:273\u2013\u200993","DOI":"10.1111\/j.1749-6632.2003.tb07088.x"},{"key":"4285_CR38","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.nlm.2013.10.010","volume":"107","author":"RW Han","year":"2014","unstructured":"Han RW, Xu HJ, Zhang RS, Wang P, Chang M, Peng YL, Deng KY, Wang R (2014) Neuropeptide S interacts with the basolateral amygdala noradrenergic system in facilitating object recognition memory consolidation. Neurobiol Learn Mem 107:32\u201336. https:\/\/doi.org\/10.1016\/j.nlm.2013.10.010","journal-title":"Neurobiol Learn Mem"},{"issue":"29","key":"4285_CR39","doi-asserted-by":"publisher","first-page":"10357","DOI":"10.1073\/pnas.0503357102","volume":"102","author":"MA Zapala","year":"2005","unstructured":"Zapala MA, Hovatta I, Ellison JA, Wodicka L, Del Rio JA, Tennant R, Tynan W, Broide RS, Helton R, Stoveken BS, Winrow C, Lockhart DJ, Reilly JF, Young WG, Bloom FE, Lockhart DJ, Barlow C (2005) Adult mouse brain gene expression patterns bear an embryologic imprint. Proc Natl Acad Sci U S A 102(29):10357\u201310362. https:\/\/doi.org\/10.1073\/pnas.0503357102","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"4285_CR40","doi-asserted-by":"publisher","first-page":"e0294354","DOI":"10.1371\/journal.pone.0294354","volume":"19","author":"S Sowndharya","year":"2024","unstructured":"Sowndharya S, Rajan KE (2024) Environmental enrichment improves social isolation-induced memory impairment: the possible role of ITSN1-Reelin-AMPA receptor signaling pathway. PLoS ONE 19(1):e0294354. https:\/\/doi.org\/10.1371\/journal.pone.0294354","journal-title":"PLoS ONE"},{"key":"4285_CR41","doi-asserted-by":"publisher","first-page":"100545","DOI":"10.1016\/j.ynstr.2023.100545","volume":"25","author":"SA Torrisi","year":"2023","unstructured":"Torrisi SA, Rizzo S, Laudani S, Ieraci A, Drago F, Leggio GM (2023) Acute stress alters recognition memory and AMPA\/NMDA receptor subunits in a sex-dependent manner. Neurobiol Stress 25:100545. https:\/\/doi.org\/10.1016\/j.ynstr.2023.100545","journal-title":"Neurobiol Stress"},{"issue":"6","key":"4285_CR42","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1097\/fbp.0000000000000739","volume":"34","author":"Z Bahari","year":"2023","unstructured":"Bahari Z, Jangravi Z, Hatef B, Valipour H, Meftahi GH (2023) Creatine supplementation protects spatial memory and long-term potentiation against chronic restraint stress. Behav Pharmacol 34(6):330\u2013339. https:\/\/doi.org\/10.1097\/fbp.0000000000000739","journal-title":"Behav Pharmacol"},{"key":"4285_CR43","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.neuroscience.2024.04.012","volume":"549","author":"SG Ghasemi","year":"2024","unstructured":"Ghasemi SG, Khoshrou A, Kakhki S, Shirinzadeh Feizabadi A, Masoudi M, Bagherifar F, Beheshti F (2024) Ascorbic acid supplementation improves adolescent stress-induced cognitive impairment through restoration of behavioral, biochemical and electrophysiological alterations in male rats. Neuroscience 549:55\u201364. https:\/\/doi.org\/10.1016\/j.neuroscience.2024.04.012","journal-title":"Neuroscience"},{"key":"4285_CR44","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.jad.2023.10.040","volume":"344","author":"B Wang","year":"2024","unstructured":"Wang B, Chen SM, Yang SQ, Jiang JM, Zhang P, Zou W, Tang XQ (2024) GDF11 mediates H2S to prevent chronic stress-induced cognitive impairment by reducing hippocampal NLRP3\/caspase-1-dependent pyroptosis. J Affect Disord 344:600\u2013611. https:\/\/doi.org\/10.1016\/j.jad.2023.10.040","journal-title":"J Affect Disord"},{"issue":"4","key":"4285_CR45","first-page":"469","volume":"65","author":"A Pokrywka","year":"2014","unstructured":"Pokrywka A, Cholbinski P, Kaliszewski P, Kowalczyk K, Konczak D, Zembron-Lacny A (2014) Metabolic modulators of the exercise response: doping control analysis of an agonist of the peroxisome proliferator-activated receptor \u03b4 (GW501516) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR). J Physiol Pharmacol 65(4):469\u2013476","journal-title":"J Physiol Pharmacol"},{"key":"4285_CR46","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jad.2013.11.025","volume":"156","author":"W Liu","year":"2014","unstructured":"Liu W, Zhai X, Li H, Ji L (2014) Depression-like behaviors in mice subjected to co-treatment of high-fat diet and corticosterone are ameliorated by AICAR and exercise. J Affect Disord 156:171\u2013177. https:\/\/doi.org\/10.1016\/j.jad.2013.11.025","journal-title":"J Affect Disord"},{"issue":"21","key":"4285_CR47","doi-asserted-by":"publisher","first-page":"18293","DOI":"10.18632\/oncotarget.4715","volume":"6","author":"D Guerrieri","year":"2015","unstructured":"Guerrieri D, van Praag H (2015) Exercise-mimetic AICAR transiently benefits brain function. Oncotarget 6(21):18293\u201318313. https:\/\/doi.org\/10.18632\/oncotarget.4715","journal-title":"Oncotarget"},{"key":"4285_CR48","doi-asserted-by":"publisher","unstructured":"Yu W, Chen L, Li X, Han T, Yang Y, Hu C, Yu W, L\u00fc Y (20230 Alteration of Metabolic Profiles during the Progression of Alzheimer\u2019s Disease. Brain Sci 13(10):1459. https:\/\/doi.org\/10.3390\/brainsci13101459","DOI":"10.3390\/brainsci13101459"},{"issue":"2","key":"4285_CR49","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1023\/b:bebm.0000048370.47097.b0","volume":"138","author":"TA Obut","year":"2004","unstructured":"Obut TA, Ovsyukova MV, Cherkasova OP (2004) Ratio between the contents of 11-dehydrocorticosterone and corticosterone after acute and repeated stress: effect of dehydroepiandrosterone sulfate. Bull Exp Biol Med 138(2):137\u2013139. https:\/\/doi.org\/10.1023\/b:bebm.0000048370.47097.b0","journal-title":"Bull Exp Biol Med"},{"issue":"2","key":"4285_CR50","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s00737-021-01186-5","volume":"25","author":"LR Standeven","year":"2022","unstructured":"Standeven LR, Osborne LM, Betz JF, Yenokyan G, Voegtline K, Hantsoo L, Payne JL (2022) Allopregnanolone and depression and anxiety symptoms across the peripartum: an exploratory study. Arch Womens Ment Health 25(2):521\u2013526. https:\/\/doi.org\/10.1007\/s00737-021-01186-5","journal-title":"Arch Womens Ment Health"},{"key":"4285_CR51","doi-asserted-by":"publisher","first-page":"100789","DOI":"10.1016\/j.yfrne.2019.100789","volume":"55","author":"G Tomaselli","year":"2019","unstructured":"Tomaselli G, Vall\u00e9e M (2019) Stress and drug abuse-related disorders: the promising therapeutic value of neurosteroids focus on pregnenolone-progesterone-allopregnanolone pathway. Front Neuroendocrinol 55:100789. https:\/\/doi.org\/10.1016\/j.yfrne.2019.100789","journal-title":"Front Neuroendocrinol"},{"issue":"6","key":"4285_CR52","doi-asserted-by":"publisher","first-page":"457","DOI":"10.2174\/1389203043379341","volume":"5","author":"MA G\u00fclpinar","year":"2004","unstructured":"G\u00fclpinar MA, Yegen BC (2004) The physiology of learning and memory: role of peptides and stress. Curr Protein Pept Sci 5(6):457\u2013473. https:\/\/doi.org\/10.2174\/1389203043379341","journal-title":"Curr Protein Pept Sci"},{"key":"4285_CR53","doi-asserted-by":"publisher","first-page":"999","DOI":"10.2147\/ndt.s161351","volume":"14","author":"Q Hu","year":"2018","unstructured":"Hu Q, Shen P, Bai S, Dong M, Liang Z, Chen Z, Wang W, Wang H, Gui S, Li P, Xie P (2018) Metabolite-related antidepressant action of diterpene ginkgolides in the prefrontal cortex. Neuropsychiatr Dis Treat 14:999\u20131011. https:\/\/doi.org\/10.2147\/ndt.s161351","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"1","key":"4285_CR54","doi-asserted-by":"publisher","first-page":"20342","DOI":"10.1038\/s41598-021-99598-x","volume":"11","author":"A Murray","year":"2021","unstructured":"Murray A, Tharmalingam S, Nguyen P, Tai TC (2021) Untargeted metabolomics reveals sex-specific differences in lipid metabolism of adult rats exposed to dexamethasone in utero. Sci Rep 11(1):20342. https:\/\/doi.org\/10.1038\/s41598-021-99598-x","journal-title":"Sci Rep"},{"issue":"5","key":"4285_CR55","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1159\/000471869","volume":"41","author":"B Han","year":"2017","unstructured":"Han B, Wang JH, Geng Y, Shen L, Wang HL, Wang YY, Wang MW (2017) Chronic stress contributes to cognitive dysfunction and hippocampal metabolic abnormalities in APP\/PS1 mice. Cell Physiol Biochem 41(5):1766\u20131776. https:\/\/doi.org\/10.1159\/000471869","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"4285_CR56","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/s1090-3798(02)00137-x","volume":"7","author":"JC Van Der Heyden","year":"2003","unstructured":"Van Der Heyden JC, Rotteveel JJ, Wevers RA (2003) Decreased homovanillic acid concentrations in cerebrospinal fluid in children without a known defect in dopamine metabolism. Eur J Paediatr Neurol 7(1):31\u201337. https:\/\/doi.org\/10.1016\/s1090-3798(02)00137-x","journal-title":"Eur J Paediatr Neurol"},{"issue":"4","key":"4285_CR57","doi-asserted-by":"publisher","first-page":"e224","DOI":"10.1038\/emm.2016.16","volume":"48","author":"J Kim","year":"2016","unstructured":"Kim J, Yang G, Kim Y, Kim J, Ha J (2016) AMPK activators: mechanisms of action and physiological activities. Exp Mol Med 48(4):e224. https:\/\/doi.org\/10.1038\/emm.2016.16","journal-title":"Exp Mol Med"},{"key":"4285_CR58","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/978-1-4615-2584-4_76","volume":"370","author":"T Page","year":"1994","unstructured":"Page T, Barshop B, Yu AL, Nyhan WL (1994) Treatment of Lesch-Nyhan syndrome with AICAR. Adv Exp Med Biol 370:353\u2013356. https:\/\/doi.org\/10.1007\/978-1-4615-2584-4_76","journal-title":"Adv Exp Med Biol"},{"issue":"2","key":"4285_CR59","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/0006-8993(89)90659-8","volume":"501","author":"SB Dunnett","year":"1989","unstructured":"Dunnett SB, Sirinathsinghji DJ, Heavens R, Rogers DC, Kuehn MR (1989) Monoamine deficiency in a transgenic (Hprt-) mouse model of Lesch-Nyhan syndrome. Brain Res 501(2):401\u2013406. https:\/\/doi.org\/10.1016\/0006-8993(89)90659-8","journal-title":"Brain Res"},{"issue":"7","key":"4285_CR60","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/nrd2605","volume":"7","author":"G Burnstock","year":"2008","unstructured":"Burnstock G (2008) Purinergic signalling and disorders of the central nervous system. Nat Rev Drug Discov 7(7):575\u2013590","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"4285_CR61","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1007\/s10545-012-9470-5","volume":"35","author":"MG Garc\u00eda","year":"2012","unstructured":"Garc\u00eda MG, Puig JG, Torres RJ (2012) Adenosine, dopamine and serotonin receptors imbalance in lymphocytes of Lesch-Nyhan patients. J Inherit Metab Dis 35(6):1129\u20131135. https:\/\/doi.org\/10.1007\/s10545-012-9470-5","journal-title":"J Inherit Metab Dis"},{"key":"4285_CR62","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.gene.2018.05.107","volume":"671","author":"M Mukilan","year":"2018","unstructured":"Mukilan M, Rajathei DM, Jeyaraj E, Kayalvizhi N, Rajan KE (2018) MiR-132 regulated olfactory bulb proteins linked to olfactory learning in greater short-nosed fruit bat Cynopterus sphinx. Gene 671:10\u201320. https:\/\/doi.org\/10.1016\/j.gene.2018.05.107","journal-title":"Gene"},{"issue":"3","key":"4285_CR63","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1002\/syn.20986","volume":"66","author":"HK M\u00fcller","year":"2012","unstructured":"M\u00fcller HK, Wegener G, Elfving B (2012) Chronic restraint stress affects serotonin transporter uptake kinetics but not binding sites in the rat hippocampus. Synapse 66(3):270\u2013272. https:\/\/doi.org\/10.1002\/syn.20986","journal-title":"Synapse"},{"issue":"8","key":"4285_CR64","doi-asserted-by":"publisher","first-page":"e18178","DOI":"10.1111\/jcmm.18178","volume":"28","author":"J Chang","year":"2024","unstructured":"Chang J, Yang H, Shan X, Zhao L, Li Y, Zhang Z, Abankwah JK, Zhang M, Bian Y, Guo Y (2024) Bergamot essential oil improves CUMS-induced depression-like behaviour in rats by protecting the plasticity of hippocampal neurons. J Cell Mol Med 28(8):e18178. https:\/\/doi.org\/10.1111\/jcmm.18178","journal-title":"J Cell Mol Med"},{"key":"4285_CR65","doi-asserted-by":"publisher","first-page":"111021","DOI":"10.1016\/j.pnpbp.2024.111021","volume":"133","author":"JTK Jung","year":"2024","unstructured":"Jung JTK, Marques LS, Brambila CA, da Cruz Weber Fulco B, Nogueira CW, Zeni G (2024) Social-single prolonged stress affects contextual fear conditioning in male and female Wistar rats: molecular insights in the amygdala. Prog Neuropsychopharmacol Biol Psychiatry 133:111021. https:\/\/doi.org\/10.1016\/j.pnpbp.2024.111021","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"43","key":"4285_CR66","doi-asserted-by":"publisher","first-page":"15597","DOI":"10.1523\/jneurosci.2445-11.2011","volume":"31","author":"X Hu","year":"2011","unstructured":"Hu X, Ballo L, Pietila L, Viesselmann C, Ballweg J, Lumbard D, Stevenson M, Merriam E, Dent EW (2011) BDNF-induced increase of PSD-95 in dendritic spines requires dynamic microtubule invasions. J Neurosci 31(43):15597\u201315603. https:\/\/doi.org\/10.1523\/jneurosci.2445-11.2011","journal-title":"J Neurosci"},{"key":"4285_CR67","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.2147\/ijgm.s413176","volume":"16","author":"Z Sha","year":"2023","unstructured":"Sha Z, Xu J, Li N, Li O (2023) Regulatory molecules of synaptic plasticity in anxiety disorder. Int J Gen Med 16:2877\u20132886. https:\/\/doi.org\/10.2147\/ijgm.s413176","journal-title":"Int J Gen Med"},{"issue":"2","key":"4285_CR68","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s00429-018-1789-8","volume":"224","author":"TE Hodges","year":"2019","unstructured":"Hodges TE, Louth EL, Bailey CDC, McCormick CM (2019) Adolescent social instability stress alters markers of synaptic plasticity and dendritic structure in the medial amygdala and lateral septum in male rats. Brain Struct Funct 224(2):643\u2013659. https:\/\/doi.org\/10.1007\/s00429-018-1789-8","journal-title":"Brain Struct Funct"},{"issue":"8","key":"4285_CR69","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1007\/s00213-023-06413-8","volume":"240","author":"S Wang","year":"2023","unstructured":"Wang S, Cai Q, Xu L, Sun Y, Wang M, Wang Y, Zhang L, Li K, Ni Z (2023) Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis. Psychopharmacology 240(8):1775\u20131787. https:\/\/doi.org\/10.1007\/s00213-023-06413-8","journal-title":"Psychopharmacology"},{"key":"4285_CR70","doi-asserted-by":"publisher","first-page":"1406687","DOI":"10.3389\/fpsyt.2024.1406687","volume":"15","author":"F Mottarlini","year":"2024","unstructured":"Mottarlini F, Rizzi B, Targa G, Buzzelli V, Di Trapano M, Rullo L, Candeletti S, Ciccocioppo R, Fattore L, Romualdi P, Fumagalli F, Trezza V, Caffino L (2024) Communal nesting shapes the sex-dependent glutamatergic response to early life stress in the rat prefrontal cortex. Front Psychiatry 15:1406687. https:\/\/doi.org\/10.3389\/fpsyt.2024.1406687","journal-title":"Front Psychiatry"},{"issue":"3","key":"4285_CR71","doi-asserted-by":"publisher","first-page":"715","DOI":"10.4103\/nrr.nrr-d-23-02000","volume":"20","author":"X Yang","year":"2025","unstructured":"Yang X, Huang YA, Marshall J (2025) Targeting TrkB-PSD-95 coupling to mitigate neurological disorders. Neural Regen Res 20(3):715\u2013724. https:\/\/doi.org\/10.4103\/nrr.nrr-d-23-02000","journal-title":"Neural Regen Res"},{"issue":"2","key":"4285_CR72","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1124\/pr.111.005108","volume":"64","author":"AE Autry","year":"2012","unstructured":"Autry AE, Monteggia LM (2012) Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev 64(2):238\u2013258. https:\/\/doi.org\/10.1124\/pr.111.005108","journal-title":"Pharmacol Rev"},{"issue":"5","key":"4285_CR73","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1007\/s12035-018-1283-6","volume":"56","author":"B Lima Giacobbo","year":"2019","unstructured":"Lima Giacobbo B, Doorduin J, Klein HC, Dierckx RAJO, Bromberg E, de Vries EFJ (2019) Brain-derived neurotrophic factor in Brain disorders: Focus on Neuroinflammation. Mol Neurobiol 56(5):3295\u20133312. https:\/\/doi.org\/10.1007\/s12035-018-1283-6","journal-title":"Mol Neurobiol"},{"issue":"1","key":"4285_CR74","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1515\/tnsci-2020-0168","volume":"12","author":"J Wu","year":"2021","unstructured":"Wu J, Liu C, Zhang L, He B, Shi WP, Shi HL, Qin C (2021) Chronic restraint stress impairs cognition via modulating HDAC2 expression. Transl Neurosci 12(1):154\u2013163. https:\/\/doi.org\/10.1515\/tnsci-2020-0168","journal-title":"Transl Neurosci"},{"issue":"834","key":"4285_CR75","doi-asserted-by":"publisher","first-page":"eadn4556","DOI":"10.1126\/scisignal.adn4556","volume":"17","author":"X Shi","year":"2024","unstructured":"Shi X, Zhou XZ, Chen G, Luo WF, Zhou C, He TJ, Naik MT, Jiang Q, Marshall J, Cao C (2024) Targeting the postsynaptic scaffolding protein PSD-95 enhances BDNF signaling to mitigate depression-like behaviors in mice. Sci Signal 17(834):eadn4556. https:\/\/doi.org\/10.1126\/scisignal.adn4556","journal-title":"Sci Signal"},{"issue":"7","key":"4285_CR76","doi-asserted-by":"publisher","first-page":"4102","DOI":"10.1007\/s12035-023-03832-8","volume":"61","author":"Y Wu","year":"2024","unstructured":"Wu Y, Zhu Z, Lan T, Li S, Li Y, Wang C, Feng Y, Mao X, Yu S (2024) Levomilnacipran improves Lipopolysaccharide-Induced dysregulation of synaptic plasticity and Depression-Like behaviors via activating BDNF\/TrkB mediated PI3K\/Akt\/mTOR signaling pathway. Mol Neurobiol 61(7):4102\u20134115. https:\/\/doi.org\/10.1007\/s12035-023-03832-8","journal-title":"Mol Neurobiol"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-024-04285-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-024-04285-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-024-04285-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T12:03:52Z","timestamp":1738411432000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-024-04285-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":76,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["4285"],"URL":"https:\/\/doi.org\/10.1007\/s11064-024-04285-8","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,18]]},"assertion":[{"value":"16 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 September 2024","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2024","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2024","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The experimental protocol reviewed and approved by Institutional Animal Ethics Committee (Ref. No.: BDU\/IAEC\/P28\/2024), assuring that the number of animals used was minimum.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"19"}}