{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T01:29:54Z","timestamp":1768699794906,"version":"3.49.0"},"reference-count":63,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T00:00:00Z","timestamp":1742256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2021JJ3119"],"award-info":[{"award-number":["2021JJ3119"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2021JJ3119"],"award-info":[{"award-number":["2021JJ3119"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82001393"],"award-info":[{"award-number":["82001393"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81973401"],"award-info":[{"award-number":["81973401"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82371477"],"award-info":[{"award-number":["82371477"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s11064-025-04367-1","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T15:17:15Z","timestamp":1742311035000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["OSGEP, A Negative Ferroptotic Regulator, Alleviates Cerebral Ischemia\u2013Reperfusion Injury Through Modulating m6A Methylation of GPX4 mRNA"],"prefix":"10.1007","volume":"50","author":[{"given":"Cheng","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanqing","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dehao","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanfei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuoyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingping","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,3,18]]},"reference":[{"key":"4367_CR1","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1161\/CIR.0000000000000885","volume":"142","author":"M Gaudino","year":"2020","unstructured":"Gaudino M, Benesch C, Bakaeen F, DeAnda A, Fremes SE, Glance L, Mess\u00e9 SR, Pandey A, Rong LQ (2020) American heart association council on cardiovascular surgery and anesthesia; Stroke council; and council on cardiovascular and stroke nursing. Considerations for reduction of risk of perioperative stroke in adult patients undergoing cardiac and thoracic aortic operations: a scientific statement from the American Heart Association. Circulation 142:193\u2013209","journal-title":"Circulation"},{"issue":"5","key":"4367_CR2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s11910-020-01033-7","volume":"20","author":"MC Leary","year":"2020","unstructured":"Leary MC, Varade P (2020) Perioperative stroke. Curr Neurol Neurosci Rep 20(5):12","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"2","key":"4367_CR3","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1177\/0271678X20910533","volume":"41","author":"Z Zhou","year":"2021","unstructured":"Zhou Z, Xu N, Matei N, McBride DW, Ding Y, Liang H, Tang J, Zhang JH (2021) Sodium butyrate attenuated neuronal apoptosis via GPR41\/G\u03b2\u03b3\/PI3K\/Akt pathway after MCAO in rats. J Cereb Blood Flow Metab 41(2):267\u2013281","journal-title":"J Cereb Blood Flow Metab"},{"issue":"23","key":"4367_CR4","doi-asserted-by":"publisher","first-page":"25564","DOI":"10.18632\/aging.203774","volume":"13","author":"D Yao","year":"2021","unstructured":"Yao D, Zhang S, Hu Z, Luo H, Mao C, Fan Y, Tang M, Liu F, Shen S, Fan L, Li M, Shi J, Li J, Ma D, Xu Y, Shi C (2021) CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation. Aging (Albany NY) 13(23):25564\u201325577","journal-title":"Aging (Albany NY)"},{"issue":"1","key":"4367_CR5","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12974-022-02501-2","volume":"19","author":"L Luo","year":"2022","unstructured":"Luo L, Liu M, Fan Y, Zhang J, Liu L, Li Y, Zhang Q, Xie H, Jiang C, Wu J, Xiao X, Wu Y (2022) Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4\/NF\u03baB\/NLRP3 signaling pathway in cerebral ischemic mice. J Neuroinflamm 19(1):141","journal-title":"J Neuroinflamm"},{"issue":"5","key":"4367_CR6","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149(5):1060\u20131072","journal-title":"Cell"},{"issue":"9","key":"4367_CR7","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1038\/s41418-022-00957-6","volume":"29","author":"Y Wu","year":"2022","unstructured":"Wu Y, Jiao H, Yue Y, He K, Jin Y, Zhang J, Zhang J, Wei Y, Luo H, Hao Z, Zhao X, Xia Q, Zhong Q, Zhang J (2022) Ubiquitin ligase E3 HUWE1\/MULE targets transferrin receptor for degradation and suppresses ferroptosis in acute liver injury. Cell Death Differ 29(9):1705\u20131718","journal-title":"Cell Death Differ"},{"key":"4367_CR8","first-page":"9911167","volume":"2022","author":"Y Wang","year":"2022","unstructured":"Wang Y, Dong Z, Zhang Z, Wang Y, Yang K, Li X (2022) Postconditioning with irisin attenuates lung ischemia\/reperfusion injury by suppressing ferroptosis via induction of the Nrf2\/HO-1 signal axis. Oxid Med Cell Longev 2022:9911167","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"4367_CR9","doi-asserted-by":"publisher","first-page":"4402","DOI":"10.1038\/s41467-021-24712-6","volume":"12","author":"W Tonnus","year":"2021","unstructured":"Tonnus W, Meyer C, Steinebach C, Belavgeni A, von M\u00e4ssenhausen A, Gonzalez NZ, Maremonti F, Gembardt F, Himmerkus N, Latk M, Locke S, Marschner J, Li W, Short S, Doll S, Ingold I, Proneth B, Daniel C, Kabgani N, Kramann R, Motika S, Hergenrother PJ, Bornstein SR, Hugo C, Becker JU, Amann K, Anders HJ, Kreisel D, Pratt D, G\u00fctschow M, Conrad M, Linkermann A (2021) Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury. Nat Commun 12(1):4402","journal-title":"Nat Commun"},{"issue":"19","key":"4367_CR10","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1161\/CIRCULATIONAHA.122.060257","volume":"147","author":"W Cai","year":"2023","unstructured":"Cai W, Liu L, Shi X, Liu Y, Wang J, Fang X, Chen Z, Ai D, Zhu Y, Zhang X (2023) Alox15\/15-HpETE aggravates myocardial ischemia-reperfusion injury by promoting cardiomyocyte ferroptosis. Circulation 147(19):1444\u20131460","journal-title":"Circulation"},{"issue":"11","key":"4367_CR11","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1038\/s41418-019-0299-4","volume":"26","author":"Y Li","year":"2019","unstructured":"Li Y, Feng D, Wang Z, Zhao Y, Sun R, Tian D, Liu D, Zhang F, Ning S, Yao J, Tian X (2019) Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia\/reperfusion. Cell Death Differ 26(11):2284\u20132299","journal-title":"Cell Death Differ"},{"key":"4367_CR12","doi-asserted-by":"publisher","first-page":"632354","DOI":"10.3389\/fncel.2021.632354","volume":"15","author":"J Chen","year":"2021","unstructured":"Chen J, Yang L, Geng L, He J, Chen L, Sun Q, Zhao J, Wang X (2021) Inhibition of acyl-coA synthetase long-chain family member 4 facilitates neurological recovery after stroke by regulation ferroptosis. Front Cell Neurosci 15:632354","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"4367_CR13","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1007\/s11064-022-03770-2","volume":"48","author":"J Liu","year":"2023","unstructured":"Liu J, Zhou Y, Xie C, Li C, Ma L, Zhang Y (2023) Anti-ferroptotic effects of bone marrow mesenchymal stem cell-derived extracellular vesicles loaded with ferrostatin-1 in cerebral ischemia-reperfusion injury associate with the GPX4\/COX-2 axis. Neurochem Res 48(2):502\u2013518","journal-title":"Neurochem Res"},{"issue":"4","key":"4367_CR14","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s12975-020-00844-7","volume":"12","author":"Y Abdul","year":"2021","unstructured":"Abdul Y, Li W, Ward R, Abdelsaid M, Hafez S, Dong G, Jamil S, Wolf V, Johnson MH, Fagan SC, Ergul A (2021) Deferoxamine treatment prevents post-stroke vasoregression and neurovascular unit remodeling leading to improved functional outcomes in type 2 male diabetic rats: role of endothelial ferroptosis. Transl Stroke Res 12(4):615\u2013630","journal-title":"Transl Stroke Res"},{"issue":"4","key":"4367_CR15","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.chembiol.2020.03.012","volume":"27","author":"M Conrad","year":"2020","unstructured":"Conrad M, Proneth B (2020) Selenium: tracing another essential element of ferroptotic cell death. Cell Chem Biol 27(4):409\u2013419","journal-title":"Cell Chem Biol"},{"issue":"3","key":"4367_CR16","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.4081\/ejh.2021.3224","volume":"65","author":"C Chen","year":"2021","unstructured":"Chen C, Huang Y, Xia P, Zhang F, Li L, Wang E, Guo Q, Ye Z (2021) Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53\/GPX4 axis. Eur J Histochem 65(3):3224","journal-title":"Eur J Histochem"},{"issue":"2","key":"4367_CR17","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1093\/nar\/gkw1181","volume":"45","author":"LC Wan","year":"2017","unstructured":"Wan LC, Maisonneuve P, Szilard RK, Lambert JP, Ng TF, Manczyk N, Huang H, Laister R, Caudy AA, Gingras AC, Durocher D, Sicheri F (2017) Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7. Nucleic Acids Res 45(2):805\u2013817","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"4367_CR18","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/ejhg.2017.30","volume":"25","author":"S Edvardson","year":"2017","unstructured":"Edvardson S, Prunetti L, Arraf A, Haas D, Bacusmo JM, Hu JF, Ta-Shma A, Dedon PC, de Cr\u00e9cy-Lagard V, Elpeleg O (2017) tRNA N6-adenosine threonylcarbamoyltransferase defect due to KAE1\/TCS3 (OSGEP) mutation manifest by neurodegeneration and renal tubulopathy. Eur J Hum Genet 25(5):545\u2013551","journal-title":"Eur J Hum Genet"},{"issue":"4","key":"4367_CR19","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.1093\/nar\/gkac056","volume":"50","author":"JT Wang","year":"2022","unstructured":"Wang JT, Zhou JB, Mao XL, Zhou L, Chen M, Zhang W, Wang ED, Zhou XL (2022) Commonality and diversity in tRNA substrate recognition in t6A biogenesis by eukaryotic KEOPSs. Nucleic Acids Res 50(4):2223\u20132239","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"4367_CR20","doi-asserted-by":"publisher","first-page":"e0191503","DOI":"10.1371\/journal.pone.0191503","volume":"13","author":"T Jobst-Schwan","year":"2018","unstructured":"Jobst-Schwan T, Schmidt JM, Schneider R, Hoogstraten CA, Ullmann JFP, Schapiro D, Majmundar AJ, Kolb A, Eddy K, Shril S, Braun DA, Poduri A, Hildebrandt F (2018) Acute multi-sgRNA knockdown of KEOPS complex genes reproduces the microcephaly phenotype of the stable knockout zebrafish model. PLoS ONE 13(1):e0191503","journal-title":"PLoS ONE"},{"issue":"5","key":"4367_CR21","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.kint.2022.11.024","volume":"103","author":"V Krausel","year":"2023","unstructured":"Krausel V, Pund L, N\u00fcsse H, Bachir H, Ricker A, Klingauf J, Weide T, Pavenst\u00e4dt H, Krahn MP, Braun DA (2023) The transcription factor ATF4 mediates endoplasmic reticulum stress-related podocyte injury and slit diaphragm defects. Kidney Int 103(5):872\u2013885","journal-title":"Kidney Int"},{"issue":"16","key":"4367_CR22","doi-asserted-by":"publisher","first-page":"5343","DOI":"10.1093\/nar\/gkp557","volume":"37","author":"J Oberto","year":"2009","unstructured":"Oberto J, Breuil N, Hecker A, Farina F, Brochier-Armanet C, Culetto E, Forterre P (2009) Qri7\/OSGEPL, the mitochondrial version of the universal Kae1\/YgjD protein, is essential for mitochondrial genome maintenance. Nucleic Acids Res 37(16):5343\u20135352","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"4367_CR23","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.cell.2019.03.032","volume":"177","author":"I Alim","year":"2019","unstructured":"Alim I, Caulfield JT, Chen Y, Swarup V, Geschwind DH, Ivanova E, Seravalli J, Ai Y, Sansing LH, Ste Marie EJ, Hondal RJ, Mukherjee S, Cave JW, Sagdullaev BT, Karuppagounder SS, Ratan RR (2019) Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke. Cell 177(5):1262\u20131279","journal-title":"Cell"},{"key":"4367_CR24","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.freeradbiomed.2023.04.014","volume":"204","author":"J Fang","year":"2023","unstructured":"Fang J, Yuan Q, Du Z, Zhang Q, Yang L, Wang M, Yang W, Yuan C, Yu J, Wu G, Hu J (2023) Overexpression of GPX4 attenuates cognitive dysfunction through inhibiting hippocampus ferroptosis and neuroinflammation after traumatic brain injury. Free Radic Biol Med 204:68\u201381","journal-title":"Free Radic Biol Med"},{"issue":"7784","key":"4367_CR25","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","volume":"575","author":"K Bersuker","year":"2019","unstructured":"Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA (2019) The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature 575(7784):688\u2013692","journal-title":"Nature"},{"key":"4367_CR26","first-page":"143","volume":"403","author":"H Imai","year":"2017","unstructured":"Imai H, Matsuoka M, Kumagai T, Sakamoto T, Koumura T (2017) Lipid peroxidation-dependent cell death regulated by GPx4 and ferroptosis. Curr Top Microbiol Immunol 403:143\u2013170","journal-title":"Curr Top Microbiol Immunol"},{"key":"4367_CR27","doi-asserted-by":"publisher","first-page":"110137","DOI":"10.1016\/j.cbi.2022.110137","volume":"366","author":"M Li","year":"2022","unstructured":"Li M, Meng Z, Yu S, Li J, Wang Y, Yang W, Wu H (2022) Baicalein ameliorates cerebral ischemia-reperfusion injury by inhibiting ferroptosis via regulating GPX4\/ACSL4\/ACSL3 axis. Chem Biol Interact 366:110137","journal-title":"Chem Biol Interact"},{"key":"4367_CR28","doi-asserted-by":"publisher","first-page":"154729","DOI":"10.1016\/j.phymed.2023.154729","volume":"113","author":"Y Liu","year":"2023","unstructured":"Liu Y, Mi Y, Wang Y, Meng Q, Xu L, Liu Y, Zhou D, Wang Y, Liang D, Li W, Li N, Hou Y (2023) Loureirin C inhibits ferroptosis after cerebral ischemia reperfusion through regulation of the Nrf2 pathway in mice. Phytomedicine 113:154729","journal-title":"Phytomedicine"},{"issue":"11","key":"4367_CR29","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1038\/mp.2017.171","volume":"22","author":"QZ Tuo","year":"2017","unstructured":"Tuo QZ, Lei P, Jackman KA, Li XL, Xiong H, Li XL, Liuyang ZY, Roisman L, Zhang ST, Ayton S, Wang Q, Crouch PJ, Ganio K, Wang XC, Pei L, Adlard PA, Lu YM, Cappai R, Wang JZ, Liu R, Bush AI (2017) Tau-mediated iron export prevents ferroptotic damage after ischemic stroke. Mol Psychiatr 22(11):1520\u20131530","journal-title":"Mol Psychiatr"},{"issue":"1","key":"4367_CR30","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1161\/STROKEAHA.120.032994","volume":"52","author":"JM Yamal","year":"2021","unstructured":"Yamal JM, Grotta JC (2021) National institutes of health stroke scale as an outcome measure for acute stroke trials. Stroke 52(1):142\u2013143","journal-title":"Stroke"},{"issue":"5","key":"4367_CR31","doi-asserted-by":"publisher","first-page":"5049","DOI":"10.1007\/s11033-011-1290-4","volume":"39","author":"Z Ye","year":"2012","unstructured":"Ye Z, Huang YM, Wang E, Zuo ZY, Guo QL (2012) Sevoflurane-induced delayed neuroprotection involves mitoK(ATP) channel opening and PKC \u03b5 activation. Mol Biol Rep 39(5):5049\u20135057","journal-title":"Mol Biol Rep"},{"issue":"2","key":"4367_CR32","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1177\/0271678X20910533","volume":"41","author":"Z Zhou","year":"2021","unstructured":"Zhou Z et al (2021) Sodium butyrate attenuated neuronal apoptosis via GPR41\/G\u03b2\u03b3\/PI3K\/Akt pathway after MCAO in rats. J Cereb Blood Flow Metab 41(2):267\u2013281","journal-title":"J Cereb Blood Flow Metab"},{"issue":"13","key":"4367_CR33","doi-asserted-by":"publisher","first-page":"2280","DOI":"10.1021\/acschemneuro.0c00682","volume":"12","author":"Z Wang","year":"2021","unstructured":"Wang Z, Xia P, Hu J, Huang Y, Zhang F, Li L, Wang E, Guo Q, Ye Z (2021) LncRNA MEG3 alleviates diabetic cognitive impairments by reducing mitochondrial-derived apoptosis through promotion of FUNDC1-related mitophagy via Rac1-ROS axis. ACS Chem Neurosci 12(13):2280\u20132307","journal-title":"ACS Chem Neurosci"},{"issue":"2","key":"4367_CR34","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","volume":"73","author":"M Gao","year":"2019","unstructured":"Gao M et al (2019) Role of mitochondria in ferroptosis. Mol Cell 73(2):354\u2013363","journal-title":"Mol Cell"},{"issue":"4","key":"4367_CR35","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41556-021-00656-3","volume":"23","author":"P Liu","year":"2021","unstructured":"Liu P, Li F, Lin J, Fukumoto T, Nacarelli T, Hao X, Kossenkov AV, Simon MC, Zhang R (2021) m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype. Nat Cell Biol 23(4):355\u2013365","journal-title":"Nat Cell Biol"},{"issue":"2","key":"4367_CR36","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nchembio.1432","volume":"10","author":"J Liu","year":"2014","unstructured":"Liu J, Yue Y, Han D, Wang X, Fu Y, Zhang L, Jia G, Yu M, Lu Z, Deng X, Dai Q, Chen W, He C (2014) A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation. Nat Chem Biol 10(2):93\u201395","journal-title":"Nat Chem Biol"},{"key":"4367_CR37","doi-asserted-by":"publisher","first-page":"e31311","DOI":"10.7554\/eLife.31311","volume":"6","author":"IA Roundtree","year":"2017","unstructured":"Roundtree IA, Luo GZ, Zhang Z, Wang X, Zhou T, Cui Y, Sha J, Huang X, Guerrero L, Xie P, He E, Shen B, He C (2017) YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs. Elife 6:e31311","journal-title":"Elife"},{"issue":"1","key":"4367_CR38","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s12943-019-1033-z","volume":"18","author":"XY Chen","year":"2019","unstructured":"Chen XY, Zhang J, Zhu JS (2019) The role of m6A RNA methylation in human cancer. Mol Cancer 18(1):103","journal-title":"Mol Cancer"},{"issue":"2","key":"4367_CR39","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1089\/ther.2014.0003","volume":"4","author":"MP Hutchens","year":"2014","unstructured":"Hutchens MP, Fujiyoshi T, Koerner IP, Herson PS (2014) Extracranial hypothermia during cardiac arrest and cardiopulmonary resuscitation is neuroprotective in vivo. Ther Hypothermia Temp Manag 4(2):79\u201387","journal-title":"Ther Hypothermia Temp Manag"},{"key":"4367_CR40","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jocn.2017.06.030","volume":"44","author":"AI Kashkoush","year":"2017","unstructured":"Kashkoush AI, Jankowitz BT, Nguyen C, Gardner PA, Wecht DA, Friedlander RM, Chang YF, Habeych M, Crammond D, Balzer J, Thirumala PD (2017) Perioperative stroke after cerebral aneurysm clipping: risk factors and postoperative impact. J Clin Neurosci 44:188\u2013195","journal-title":"J Clin Neurosci"},{"key":"4367_CR41","doi-asserted-by":"publisher","first-page":"025","DOI":"10.1093\/ejcts\/ezac025","volume":"62","author":"K Jonsson","year":"2022","unstructured":"Jonsson K, Barbu M, Nielsen SJ, Hafsteinsdottir B, Gudbjartsson T, Jensen EM, Silverborn M, Jeppsson A (2022) Perioperative stroke and survival in coronary artery bypass grafting patients: a SWEDEHEART study. Eur J Cardiothorac Surg 62:025","journal-title":"Eur J Cardiothorac Surg"},{"issue":"8","key":"4367_CR42","doi-asserted-by":"publisher","first-page":"2002","DOI":"10.1161\/STROKEAHA.119.024995","volume":"50","author":"T Wilcox","year":"2019","unstructured":"Wilcox T, Smilowitz NR, Xia Y, Berger JS (2019) Cardiovascular risk scores to predict perioperative stroke in noncardiac surgery. Stroke 50(8):2002\u20132006","journal-title":"Stroke"},{"issue":"4","key":"4367_CR43","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1080\/10715762.2020.1867314","volume":"55","author":"H Shi","year":"2021","unstructured":"Shi H, Almutairi M, Moskovitz J, Xu YG (2021) Recent advances in iron homeostasis and regulation\u2014a focus on epigenetic regulation and stroke. Free Radic Res 55(4):375\u2013383","journal-title":"Free Radic Res"},{"issue":"8","key":"4367_CR44","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1212\/WNL.54.8.1568","volume":"54","author":"A D\u00e1valos","year":"2000","unstructured":"D\u00e1valos A, Castillo J, Marrugat J, Fernandez-Real JM, Armengou A, Cacabelos P, Rama R (2000) Body iron stores and early neurologic deterioration in acute cerebral infarction. Neurology 54(8):1568\u20131574","journal-title":"Neurology"},{"key":"4367_CR45","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/978-981-13-9589-5_6","volume":"1173","author":"MMA Almutairi","year":"2019","unstructured":"Almutairi MMA, Xu G, Shi H (2019) Iron pathophysiology in stroke. Adv Exp Med Biol 1173:105\u2013123","journal-title":"Adv Exp Med Biol"},{"issue":"10","key":"4367_CR46","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1038\/ng.3933","volume":"49","author":"DA Braun","year":"2017","unstructured":"Braun DA, Rao J, Mollet G, Schapiro D, Daugeron MC, Tan W, Gribouval O, Boyer O, Revy P et al (2017) Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly. Nat Genet 49(10):1529\u20131538","journal-title":"Nat Genet"},{"key":"4367_CR47","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.cca.2021.10.012","volume":"523","author":"H Teng","year":"2021","unstructured":"Teng H, Liang C, Liang D, Li Z, Wu L (2021) Novel variants in OSGEP leading to Galloway-Mowat syndrome by altering its subcellular localization. Clin Chim Acta 523:297\u2013303","journal-title":"Clin Chim Acta"},{"key":"4367_CR48","doi-asserted-by":"publisher","first-page":"899991","DOI":"10.3389\/fped.2022.899991","volume":"10","author":"S Xu","year":"2022","unstructured":"Xu S, Hu L, Yang L, Wu B, Cao Y, Zhang R, Xu X, Ma H, Zhou W, Cheng G, Zhang P, Hu L (2022) Galloway-Mowat syndrome type 3 caused by OSGEP gene variants: a case report and literature review. Front Pediatr 10:899991","journal-title":"Front Pediatr"},{"issue":"5","key":"4367_CR49","doi-asserted-by":"publisher","first-page":"e778","DOI":"10.1002\/ctm2.778","volume":"12","author":"L Liu","year":"2022","unstructured":"Liu L, He J, Sun G, Huang N, Bian Z, Xu C, Zhang Y, Cui Z, Xu W, Sun F, Zhuang C, Man Q, Gu S (2022) The N6-methyladenosine modification enhances ferroptosis resistance through inhibiting SLC7A11 mRNA deadenylation in hepatoblastoma. Clin Transl Med 12(5):e778","journal-title":"Clin Transl Med"},{"key":"4367_CR50","doi-asserted-by":"publisher","first-page":"102262","DOI":"10.1016\/j.redox.2022.102262","volume":"51","author":"Y Wang","year":"2022","unstructured":"Wang Y, Zhang M, Bi R, Su Y, Quan F, Lin Y, Yue C, Cui X, Zhao Q, Liu S, Yang Y, Zhang D, Cao Q, Gao X (2022) ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury. Redox Biol 51:102262","journal-title":"Redox Biol"},{"issue":"1","key":"4367_CR51","doi-asserted-by":"publisher","first-page":"e202100253","DOI":"10.1002\/cbic.202100253","volume":"23","author":"MB Cordon","year":"2022","unstructured":"Cordon MB, Jacobsen KM, Nielsen CS, Hjerrild P, Poulsen TB (2022) Forward chemical genetic screen for oxygen-dependent cytotoxins uncovers new covalent fragments that target GPX4. ChemBioChem 23(1):e202100253","journal-title":"ChemBioChem"},{"issue":"12","key":"4367_CR52","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1038\/ncb3064","volume":"16","author":"JP Friedmann Angeli","year":"2014","unstructured":"Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA et al (2014) Inactivation of the ferroptosis regulator GPX4 triggers acute renal failure in mice. Nat Cell Biol 16(12):1180\u20131191","journal-title":"Nat Cell Biol"},{"issue":"9","key":"4367_CR53","doi-asserted-by":"publisher","first-page":"2695","DOI":"10.7150\/ijbs.80735","volume":"19","author":"L Sanguigno","year":"2023","unstructured":"Sanguigno L, Guida N, Anzilotti S, Cuomo O, Mascolo L, Serani A, Brancaccio P, Pennacchio G, Licastro E, Pignataro G, Molinaro P, Annunziato L, Formisano L (2023) Stroke by inducing HDAC9-dependent deacetylation of HIF-1 and Sp1, promotes TfR1 transcription and GPX4 reduction, thus determining ferroptotic neuronal death. Int J Biol Sci 19(9):2695\u20132710","journal-title":"Int J Biol Sci"},{"key":"4367_CR54","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.redox.2017.01.021","volume":"12","author":"WS Hambright","year":"2017","unstructured":"Hambright WS, Fonseca RS, Chen L, Na R, Ran Q (2017) Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration. Redox Biol 12:8\u201317","journal-title":"Redox Biol"},{"issue":"1","key":"4367_CR55","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12943-022-01500-4","volume":"21","author":"Y An","year":"2022","unstructured":"An Y, Duan H (2022) The role of m6A RNA methylation in cancer metabolism. Mol Cancer 21(1):14","journal-title":"Mol Cancer"},{"issue":"3","key":"4367_CR56","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1080\/14737159.2022.2049246","volume":"22","author":"H Chang","year":"2022","unstructured":"Chang H, Yang J, Wang Q, Zhao J, Zhu R (2022) Role of N6-methyladenosine modification in pathogenesis of ischemic stroke. Exp Rev Mol Diagn 22(3):295\u2013303","journal-title":"Exp Rev Mol Diagn"},{"issue":"1","key":"4367_CR57","doi-asserted-by":"publisher","first-page":"4892","DOI":"10.1038\/s41467-019-12801-6","volume":"10","author":"Y Shi","year":"2019","unstructured":"Shi Y, Fan S, Wu M, Zuo Z, Li X, Jiang L, Shen Q, Xu P, Zeng L, Zhou Y, Huang Y, Yang Z, Zhou J, Gao J, Zhou H, Xu S, Ji H, Shi P, Wu DD, Yang C, Chen Y (2019) YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression. Nat Commun 10(1):4892","journal-title":"Nat Commun"},{"key":"4367_CR58","doi-asserted-by":"publisher","first-page":"869081","DOI":"10.3389\/fnins.2022.869081","volume":"16","author":"Y Li","year":"2022","unstructured":"Li Y, Li H, Luo Y, Li X, Chen Z, Zhang W, Li F, Ling L (2022) The alteration profiles of m6A-tagged circRNAs in the peri-infarct cortex after cerebral ischemia in mice. Front Neurosci 16:869081","journal-title":"Front Neurosci"},{"issue":"2","key":"4367_CR59","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.neuron.2017.12.036","volume":"97","author":"YL Weng","year":"2018","unstructured":"Weng YL, Wang X, An R, Cassin J, Vissers C, Liu Y, Liu Y, Xu T, Wang X, Wong SZH, Joseph J, Dore LC, Dong Q, Zheng W, Jin P, Wu H, Shen B, Zhuang X, He C, Liu K, Song H, Ming GL (2018) Epitranscriptomic m6A regulation of axon regeneration in the adult mammalian nervous system. Neuron 97(2):313\u2013325","journal-title":"Neuron"},{"issue":"11","key":"4367_CR60","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1038\/s41419-020-03186-2","volume":"11","author":"Z Zhang","year":"2020","unstructured":"Zhang Z, Wang Q, Zhao X, Shao L, Liu G, Zheng X, Xie L, Zhang Y, Sun C, Xu R (2020) YTHDC1 mitigates ischemic stroke by promoting Akt phosphorylation through destabilizing PTEN mRNA. Cell Death Dis 11(11):977","journal-title":"Cell Death Dis"},{"issue":"9","key":"4367_CR61","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1038\/nmeth.2131","volume":"9","author":"AR Kristensen","year":"2012","unstructured":"Kristensen AR, Gsponer J, Foster LJ (2012) A high-throughput approach for measuring temporal changes in the interactome. Nat Methods 9(9):907\u2013909","journal-title":"Nat Methods"},{"key":"4367_CR62","doi-asserted-by":"publisher","first-page":"102828","DOI":"10.1016\/j.jaut.2022.102828","volume":"129","author":"Z Ma","year":"2022","unstructured":"Ma Z, Zhou Y, Wang Y, Xu Y, Liu Y, Liu Y, Jiang M, Zhang X, Cao X (2022) RNA-binding protein hnRNPUL1 binds \u03baB sites to attenuate NF-\u03baB-mediated inflammation. J Autoimmun 129:102828","journal-title":"J Autoimmun"},{"key":"4367_CR63","doi-asserted-by":"publisher","first-page":"10475","DOI":"10.1038\/srep10475","volume":"5","author":"G Gurunathan","year":"2015","unstructured":"Gurunathan G, Yu Z, Coulombe Y, Masson JY, Richard S (2015) Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage. Sci Rep 5:10475","journal-title":"Sci Rep"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-025-04367-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-025-04367-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-025-04367-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T05:01:47Z","timestamp":1745557307000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-025-04367-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,18]]},"references-count":63,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["4367"],"URL":"https:\/\/doi.org\/10.1007\/s11064-025-04367-1","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,18]]},"assertion":[{"value":"18 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 February 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interest"}}],"article-number":"122"}}