{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:26:54Z","timestamp":1784755614947,"version":"3.55.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1007\/s11064-025-04388-w","type":"journal-article","created":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T09:00:14Z","timestamp":1744448414000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["OAB-14 Attenuated Glymphatic System Disorder, Neuroinflammation and Dyskinesia in Parkinson\u2019s Disease Model Mice Induced by Rotenone"],"prefix":"10.1007","volume":"50","author":[{"given":"Xinyu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruolin","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-liang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"key":"4388_CR1","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13024-020-00408-1","volume":"15","author":"K Belarbi","year":"2020","unstructured":"Belarbi K, Cuvelier E, Bonte MA, Desplanque M, Gressier B, Devos D, Chartier-Harlin MC (2020) Glycosphingolipids and neuroinflammation in Parkinson\u2019s disease. Mol Neurodegener 15:59. https:\/\/doi.org\/10.1186\/s13024-020-00408-1","journal-title":"Mol Neurodegener"},{"key":"4388_CR2","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13024-023-00600-z","volume":"18","author":"A Haider","year":"2023","unstructured":"Haider A, Elghazawy NH, Dawoud A, Gebhard C, Wichmann T, Sippl W, Hoener M, Arenas E, Liang SH (2023) Translational molecular imaging and drug development in Parkinson\u2019s disease. Mol Neurodegener 18:11. https:\/\/doi.org\/10.1186\/s13024-023-00600-z","journal-title":"Mol Neurodegener"},{"key":"4388_CR3","doi-asserted-by":"publisher","first-page":"102308","DOI":"10.1016\/j.redox.2022.102308","volume":"52","author":"X Han","year":"2022","unstructured":"Han X, Liu Y, Dai Y, Xu T, Hu Q, Yi X, Rui L, Hu G, Hu J (2022) Neuronal SH2B1 attenuates apoptosis in an MPTP mouse model of Parkinson\u2019s disease via promoting PLIN4 degradation. Redox Biol 52:102308. https:\/\/doi.org\/10.1016\/j.redox.2022.102308","journal-title":"Redox Biol"},{"key":"4388_CR4","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13024-016-0113-4","volume":"11","author":"DM Mason","year":"2016","unstructured":"Mason DM, Nouraei N, Pant DB, Miner KM, Hutchison DF, Luk KC, Stolz JF, Leak RK (2016) Transmission of alpha-synucleinopathy from olfactory structures deep into the Temporal lobe. Mol Neurodegener 11:49. https:\/\/doi.org\/10.1186\/s13024-016-0113-4","journal-title":"Mol Neurodegener"},{"key":"4388_CR5","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41746-022-00568-y","volume":"5","author":"AS Chandrabhatla","year":"2022","unstructured":"Chandrabhatla AS, Pomeraniec IJ, Ksendzovsky A (2022) Co-evolution of machine learning and digital technologies to improve monitoring of Parkinson\u2019s disease motor symptoms. NPJ Digit Med 5:32. https:\/\/doi.org\/10.1038\/s41746-022-00568-y","journal-title":"NPJ Digit Med"},{"key":"4388_CR6","doi-asserted-by":"publisher","first-page":"3067","DOI":"10.1093\/brain\/awaa262","volume":"143","author":"R Brauer","year":"2020","unstructured":"Brauer R, Wei L, Ma T, Athauda D, Girges C, Vijiaratnam N, Auld G, Whittlesea C, Wong I, Foltynie T (2020) Diabetes medications and risk of Parkinson\u2019s disease: a cohort study of patients with diabetes. Brain 143:3067\u20133076. https:\/\/doi.org\/10.1093\/brain\/awaa262","journal-title":"Brain"},{"key":"4388_CR7","doi-asserted-by":"publisher","first-page":"e2103827","DOI":"10.1002\/advs.202103827","volume":"9","author":"F Wianny","year":"2022","unstructured":"Wianny F, Dzahini K, Fifel K, Wilson CRE, Bernat A, Dolmazon V, Misery P, Lamy C, Giroud P, Cooper HM, Knoblauch K, Procyk E, Kennedy H, Savatier P, Dehay C, Vezoli J (2022) Induced cognitive impairments reversed by grafts of neural precursors: A longitudinal study in a macaque model of Parkinson\u2019s disease. Adv Sci (Weinh) 9:e2103827. https:\/\/doi.org\/10.1002\/advs.202103827","journal-title":"Adv Sci (Weinh)"},{"key":"4388_CR8","doi-asserted-by":"publisher","first-page":"3699","DOI":"10.1093\/brain\/awaa320","volume":"143","author":"BE Lee","year":"2020","unstructured":"Lee BE, Kim HY, Kim HJ, Jeong H, Kim BG, Lee HE, Lee J, Kim HB, Lee SE, Yang YR, Yi EC, Hanover JA, Myung K, Suh PG, Kwon T, Kim JI (2020) O-GlcNAcylation regulates dopamine neuron function, survival and degeneration in Parkinson disease. Brain 143:3699\u20133716. https:\/\/doi.org\/10.1093\/brain\/awaa320","journal-title":"Brain"},{"key":"4388_CR9","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1001\/jamaneurol.2017.0943","volume":"74","author":"R Pahwa","year":"2017","unstructured":"Pahwa R, Tanner CM, Hauser RA, Isaacson SH, Nausieda PA, Truong DD, Agarwal P, Hull KL, Lyons KE, Johnson R, Stempien MJ (2017) ADS-5102 (Amantadine) Extended-Release capsules for Levodopa-Induced dyskinesia in Parkinson disease (EASE LID Study): A Randomized Clinical Trial. JAMA Neurol 74:941\u2013949. https:\/\/doi.org\/10.1001\/jamaneurol.2017.0943","journal-title":"JAMA Neurol"},{"key":"4388_CR10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13024-022-00520-4","volume":"17","author":"W Cai","year":"2022","unstructured":"Cai W, Srivastava P, Feng D, Lin Y, Vanderburg CR, Xu Y, McLean P, Frosch MP, Fisher DE, Schwarzschild MA, Chen X (2022) Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson\u2019s disease. Mol Neurodegener 17:16. https:\/\/doi.org\/10.1186\/s13024-022-00520-4","journal-title":"Mol Neurodegener"},{"key":"4388_CR11","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s40035-019-0159-7","volume":"8","author":"JZ Wu","year":"2019","unstructured":"Wu JZ, Ardah M, Haikal C, Svanbergsson A, Diepenbroek M, Vaikath NN, Li W, Wang ZY, Outeiro TF, El-Agnaf OM, Li JY (2019) Dihydromyricetin and Salvianolic acid B inhibit alpha-synuclein aggregation and enhance chaperone-mediated autophagy. Transl Neurodegener 8:18. https:\/\/doi.org\/10.1186\/s40035-019-0159-7","journal-title":"Transl Neurodegener"},{"key":"4388_CR12","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13024-016-0094-3","volume":"11","author":"Y Zhou","year":"2016","unstructured":"Zhou Y, Lu M, Du RH, Qiao C, Jiang CY, Zhang KZ, Ding JH, Hu G (2016) MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson\u2019s disease. Mol Neurodegener 11:28. https:\/\/doi.org\/10.1186\/s13024-016-0094-3","journal-title":"Mol Neurodegener"},{"key":"4388_CR13","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s13024-022-00564-6","volume":"17","author":"M Iba","year":"2022","unstructured":"Iba M, McDevitt RA, Kim C, Roy R, Sarantopoulou D, Tommer E, Siegars B, Sallin M, Kwon S, Sen JM, Sen R, Masliah E (2022) Aging exacerbates the brain inflammatory micro-environment contributing to alpha-synuclein pathology and functional deficits in a mouse model of DLB\/PD. Mol Neurodegener 17:60. https:\/\/doi.org\/10.1186\/s13024-022-00564-6","journal-title":"Mol Neurodegener"},{"key":"4388_CR14","doi-asserted-by":"publisher","first-page":"119292","DOI":"10.1016\/j.biomaterials.2019.119292","volume":"217","author":"WC Ballance","year":"2019","unstructured":"Ballance WC, Qin EC, Chung HJ, Gillette MU, Kong H (2019) Reactive oxygen species-responsive drug delivery systems for the treatment of neurodegenerative diseases. Biomaterials 217:119292. https:\/\/doi.org\/10.1016\/j.biomaterials.2019.119292","journal-title":"Biomaterials"},{"key":"4388_CR15","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s13024-017-0195-7","volume":"12","author":"S Venezia","year":"2017","unstructured":"Venezia S, Refolo V, Polissidis A, Stefanis L, Wenning GK, Stefanova N (2017) Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal alpha-synucleinopathy. Mol Neurodegener 12:52. https:\/\/doi.org\/10.1186\/s13024-017-0195-7","journal-title":"Mol Neurodegener"},{"key":"4388_CR16","doi-asserted-by":"publisher","first-page":"1476","DOI":"10.1093\/brain\/awaa090","volume":"143","author":"M Guo","year":"2020","unstructured":"Guo M, Wang J, Zhao Y, Feng Y, Han S, Dong Q, Cui M, Tieu K (2020) Microglial exosomes facilitate alpha-synuclein transmission in Parkinson\u2019s disease. Brain 143:1476\u20131497. https:\/\/doi.org\/10.1093\/brain\/awaa090","journal-title":"Brain"},{"key":"4388_CR17","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/s1322-7696(08)60047-5","volume":"10","author":"J Lliffe","year":"2003","unstructured":"Lliffe J, Bryant R (2003) Nursing leadership in Australia: the Australian peak nursing forum. Collegian 10:5\u20136. https:\/\/doi.org\/10.1016\/s1322-7696(08)60047-5","journal-title":"Collegian"},{"key":"4388_CR18","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s40035-022-00293-2","volume":"11","author":"DM Lopes","year":"2022","unstructured":"Lopes DM, Llewellyn SK, Harrison IF (2022) Propagation of Tau and alpha-synuclein in the brain: therapeutic potential of the glymphatic system. Transl Neurodegener 11:19. https:\/\/doi.org\/10.1186\/s40035-022-00293-2","journal-title":"Transl Neurodegener"},{"key":"4388_CR19","doi-asserted-by":"publisher","unstructured":"Mogensen FL, Delle C, Nedergaard M (2021) The glymphatic system (En)during inflammation. Int J Mol Sci 22. https:\/\/doi.org\/10.3390\/ijms22147491","DOI":"10.3390\/ijms22147491"},{"key":"4388_CR20","first-page":"174","volume":"8","author":"T Shen","year":"2022","unstructured":"Shen T, Yue Y, Ba F, He T, Tang X, Hu X, Pu J, Huang C, Lv W, Zhang BJPD (2022) Diffusion along perivascular spaces as marker for impairment of glymphatic system in Parkinson\u2019s disease. Parkinsonism Relat Disord 8:174","journal-title":"Parkinsonism Relat Disord"},{"key":"4388_CR21","doi-asserted-by":"crossref","first-page":"205846011560963","DOI":"10.1177\/2058460115609635","volume":"4","author":"PK Eide","year":"2015","unstructured":"Eide PK, Ringstad GJA (2015) MRI with intrathecal MRI gadolinium contrast medium administration: a possible method to assess glymphatic function in human brain. Acta Radiol Open 4:2058460115609635","journal-title":"Acta Radiol Open"},{"key":"4388_CR22","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1093\/brain\/awx191","volume":"140","author":"G Ringstad","year":"2017","unstructured":"Ringstad G, Vatnehol SAS, Eide PKJB (2017) Glymphatic MRI in idiopathic normal pressure hydrocephalus. Brain 140:2691\u20132705","journal-title":"Brain"},{"key":"4388_CR23","first-page":"648","volume":"40","author":"R Watts","year":"2019","unstructured":"Watts R, Steinklein J, Waldman L, Zhou X, Filippi CJAJN (2019) Measuring glymphatic flow in man using quantitative contrast-enhanced MRI. AJNR Am JNeuroradiol 40:648\u2013651","journal-title":"AJNR Am JNeuroradiol"},{"key":"4388_CR24","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/s41591-020-01198-1","volume":"27","author":"X-B Ding","year":"2021","unstructured":"Ding X-B, Wang X-X, Xia D-H, Liu H, Tian H-Y, Fu Y, Chen Y-K, Qin C, Wang J-Q, Xiang ZJN (2021) Impaired meningeal lymphatic drainage in patients with idiopathic Parkinson\u2019s disease. Nat Med 27:411\u2013418","journal-title":"Nat Med"},{"key":"4388_CR25","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1126\/science.1227157","volume":"338","author":"KC Luk","year":"2012","unstructured":"Luk KC, Kehm V, Carroll J, Zhang B, O\u2019Brien P, Trojanowski JQ, Lee VM-YJS (2012) Pathological \u03b1-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 338:949\u2013953","journal-title":"Science"},{"key":"4388_CR26","doi-asserted-by":"publisher","unstructured":"Cui H, Wang W, Zheng X, Xia D, Liu H, Qin C, Tian H, Teng JJJMN (2021) Decreased AQP4 expression aggravates \u0251-synuclein pathology in Parkinson\u2019s disease mice, possibly via impaired glymphatic clearance. J Mol Neurosci 71:2500\u20132513. https:\/\/doi.org\/10.1007\/s12031-021-01836-4","DOI":"10.1007\/s12031-021-01836-4"},{"key":"4388_CR27","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.lfs.2018.03.057","volume":"201","author":"C Zhang","year":"2018","unstructured":"Zhang C, Lin J, Wei F, Song J, Chen W, Shan L, Xue R, Wang G, Tao J, Zhang GJL (2018) Characterizing the glymphatic influx by utilizing intracisternal infusion of fluorescently conjugated cadaverine. Life Sci 201:150\u2013160","journal-title":"Life Sci"},{"key":"4388_CR28","doi-asserted-by":"publisher","first-page":"eabo0155","DOI":"10.1126\/sciadv.abo0155","volume":"8","author":"M Paradis","year":"2022","unstructured":"Paradis M, Kucharowski N, Edwards Faret G, Maya Palacios SJ, Meyer C, Stumpges B, Jamitzky I, Kalinowski J, Thiele C, Bauer R, Paululat A, Sellin J, Bulow MH (2022) The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity. Sci Adv 8:eabo0155. https:\/\/doi.org\/10.1126\/sciadv.abo0155","journal-title":"Sci Adv"},{"key":"4388_CR29","doi-asserted-by":"publisher","first-page":"110911","DOI":"10.1016\/j.intimp.2023.110911","volume":"124","author":"F Zhang","year":"2023","unstructured":"Zhang F, Cao R-l, Liu P, Chi T-y, Ji X-f, Zheng Z-h, Chen G-l, Zou L-bJII (2023) The bexarotene derivative OAB-14 ameliorates cognitive decline in APP\/PS1 Transgenic mice by suppressing microglia-mediated neuroinflammation through the PPAR-\u03b3 pathway. Int Lmmunopharmacol 124:110911","journal-title":"Int Lmmunopharmacol"},{"key":"4388_CR30","doi-asserted-by":"publisher","first-page":"3985","DOI":"10.1021\/acschemneuro.1c00209","volume":"12","author":"X Guo","year":"2021","unstructured":"Guo X, Bao X, Wang X, Liu D, Liu P, Chi T, Ji X, Zheng Z, Chen G, Zou L (2021) OAB-14 effectively ameliorates the dysfunction of the Endosomal-Autophagic-Lysosomal pathway in APP\/PS1 Transgenic mice. ACS Chem Neurosci 12:3985\u20133993. https:\/\/doi.org\/10.1021\/acschemneuro.1c00209","journal-title":"ACS Chem Neurosci"},{"key":"4388_CR31","doi-asserted-by":"publisher","unstructured":"Zhang X, Cao R, Zhu C, Yang L, Zheng N, Ji W, Liu P, Chi T, Ji X, Zheng Z, Chen G, Zou L (2023) Mechanism of anti-AD action of OAB-14 by enhancing the function of glymphatic system. Neurochem Int 105633. https:\/\/doi.org\/10.1016\/j.neuint.2023.105633","DOI":"10.1016\/j.neuint.2023.105633"},{"key":"4388_CR32","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.bbadis.2018.10.028","volume":"1865","author":"C Yuan","year":"2019","unstructured":"Yuan C, Guo X, Zhou Q, Du F, Jiang W, Zhou X, Liu P, Chi T, Ji X, Gao J, Chen C, Lang H, Xu J, Liu D, Yang Y, Qiu S, Tang X, Chen G, Zou L (2019) OAB-14, a bexarotene derivative, improves Alzheimer\u2019s disease-related pathologies and cognitive impairments by increasing beta-amyloid clearance in APP\/PS1 mice. Biochim Biophys Acta Mol Basis Dis 1865:161\u2013180. https:\/\/doi.org\/10.1016\/j.bbadis.2018.10.028","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"4388_CR33","doi-asserted-by":"publisher","first-page":"850904","DOI":"10.3389\/fnmol.2022.850904","volume":"15","author":"Q Tian","year":"2022","unstructured":"Tian Q, Yang X, Du J, Huang H, Liu W, Zhao P (2022) Translocator protein ligand Etifoxine attenuates MPTP-Induced neurotoxicity. Front Mol Neurosci 15:850904. https:\/\/doi.org\/10.3389\/fnmol.2022.850904","journal-title":"Front Mol Neurosci"},{"key":"4388_CR34","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s40478-020-01073-7","volume":"8","author":"P McMillan","year":"2020","unstructured":"McMillan P, Wheeler J, Gatlin RE, Taylor L, Strovas T, Baum M, Bird TD, Latimer C, Keene CD, Kraemer BC, Liachko NF (2020) Adult onset pan-neuronal human Tau tubulin kinase 1 expression causes severe cerebellar neurodegeneration in mice. Acta Neuropathol Commun 8:200. https:\/\/doi.org\/10.1186\/s40478-020-01073-7","journal-title":"Acta Neuropathol Commun"},{"key":"4388_CR35","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1186\/s12974-020-01978-z","volume":"17","author":"H Yu","year":"2020","unstructured":"Yu H, Cao X, Li W, Liu P, Zhao Y, Song L, Chen J, Chen B, Yu W, Xu Y (2020) Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling. J Neuroinflammation 17:322. https:\/\/doi.org\/10.1186\/s12974-020-01978-z","journal-title":"J Neuroinflammation"},{"key":"4388_CR36","doi-asserted-by":"publisher","first-page":"e24415","DOI":"10.1002\/jcla.24415","volume":"36","author":"K Tang","year":"2022","unstructured":"Tang K, Lv D, Miao L, Mao Y, Yu X (2022) LncRNA TUG1 functions as a CeRNA for miR-1-3p to promote cell proliferation in hepatic carcinogenesis. J Clin Lab Anal 36:e24415. https:\/\/doi.org\/10.1002\/jcla.24415","journal-title":"J Clin Lab Anal"},{"key":"4388_CR37","doi-asserted-by":"publisher","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","volume":"4","author":"JJ Iliff","year":"2012","unstructured":"Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE, Deane R, Goldman SA, Nagelhus EA, Nedergaard M (2012) A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med 4:147ra111. https:\/\/doi.org\/10.1126\/scitranslmed.3003748","journal-title":"Sci Transl Med"},{"key":"4388_CR38","doi-asserted-by":"publisher","unstructured":"(2019) Poster viewing sessions PB01-B01 to PB03-V09. J Cereb Blood Flow Metab 39:167\u2013523. https:\/\/doi.org\/10.1177\/0271678X19851020","DOI":"10.1177\/0271678X19851020"},{"key":"4388_CR39","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s12987-019-0152-7","volume":"16","author":"M Croci","year":"2019","unstructured":"Croci M, Vinje V, Rognes ME (2019) Uncertainty quantification of parenchymal tracer distribution using random diffusion and convective velocity fields. Fluids Barriers CNS 16:32. https:\/\/doi.org\/10.1186\/s12987-019-0152-7","journal-title":"Fluids Barriers CNS"},{"key":"4388_CR40","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1111\/j.1460-9568.2012.08108.x","volume":"36","author":"JE Rubin","year":"2012","unstructured":"Rubin JE, McIntyre CC, Turner RS, Wichmann T (2012) Basal ganglia activity patterns in parkinsonism and computational modeling of their downstream effects. Eur J Neurosci 36:2213\u20132228. https:\/\/doi.org\/10.1111\/j.1460-9568.2012.08108.x","journal-title":"Eur J Neurosci"},{"key":"4388_CR41","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1002\/jnr.24230","volume":"96","author":"S Bhattacharya","year":"2018","unstructured":"Bhattacharya S, Ma Y, Dunn AR, Bradner JM, Scimemi A, Miller GW, Traynelis SF, Wichmann T (2018) NMDA receptor Blockade ameliorates abnormalities of Spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate. J Neurosci Res 96:1324\u20131335. https:\/\/doi.org\/10.1002\/jnr.24230","journal-title":"J Neurosci Res"},{"key":"4388_CR42","doi-asserted-by":"publisher","first-page":"AF01","DOI":"10.7860\/JCDR\/2017\/24955.9604","volume":"11","author":"SP Maniyath","year":"2017","unstructured":"Maniyath SP, Solaiappan N, Rathinasamy M (2017) Neurobehavioural changes in a Hemiparkinsonian rat model induced by rotenone. J Clin Diagn Res 11:AF01\u2013AF05. https:\/\/doi.org\/10.7860\/JCDR\/2017\/24955.9604","journal-title":"J Clin Diagn Res"},{"key":"4388_CR43","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/j.yexcr.2008.02.014","volume":"314","author":"SC Lo","year":"2008","unstructured":"Lo SC, Hannink M (2008) PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria. Exp Cell Res 314:1789\u20131803. https:\/\/doi.org\/10.1016\/j.yexcr.2008.02.014","journal-title":"Exp Cell Res"},{"key":"4388_CR44","doi-asserted-by":"publisher","unstructured":"Hamamah S, Aghazarian A, Nazaryan A, Hajnal A, Covasa M (2022) Role of Microbiota-Gut-Brain axis in regulating dopaminergic signaling. Biomedicines 10. https:\/\/doi.org\/10.3390\/biomedicines10020436","DOI":"10.3390\/biomedicines10020436"},{"key":"4388_CR45","doi-asserted-by":"publisher","first-page":"2853","DOI":"10.1007\/s11011-022-01087-1","volume":"37","author":"P Parekh","year":"2022","unstructured":"Parekh P, Sharma N, Sharma M, Gadepalli A, Sayyed AA, Chatterjee S, Kate A, Khairnar AJMBD (2022) AMPK-dependent autophagy activation and alpha-Synuclein clearance: a putative mechanism behind alpha-mangostin\u2019s neuroprotection in a rotenone-induced mouse model of Parkinson\u2019s disease. Metab Brain Dis 37:2853\u20132870","journal-title":"Metab Brain Dis"},{"key":"4388_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/mmr.2022.12607","volume":"25","author":"J Zhang","year":"2022","unstructured":"Zhang J, Sun B, Yang J, Chen Z, Li Z, Zhang N, Li H, Shen LJMMR (2022) Comparison of the effect of rotenone and 1\u2013methyl\u20134\u2013phenyl\u20131, 2, 3, 6\u2013tetrahydropyridine on inducing chronic Parkinson\u2019s disease in mouse models. Mol Med Rep 25:1\u201313","journal-title":"Mol Med Rep"},{"key":"4388_CR47","doi-asserted-by":"publisher","first-page":"e1002640","DOI":"10.1371\/journal.pmed.1002640","volume":"15","author":"GE Nam","year":"2018","unstructured":"Nam GE, Kim SM, Han K, Kim NH, Chung HS, Kim JW, Han B, Cho SJ, Yu JH, Park YG, Choi KM (2018) Metabolic syndrome and risk of Parkinson disease: A nationwide cohort study. PLoS Med 15:e1002640. https:\/\/doi.org\/10.1371\/journal.pmed.1002640","journal-title":"PLoS Med"},{"key":"4388_CR48","doi-asserted-by":"publisher","first-page":"5143","DOI":"10.3892\/mmr.2017.7303","volume":"16","author":"JL Xin","year":"2017","unstructured":"Xin JL, Zhang Y, Li Y, Zhang LZ, Lin Y, Zheng LW (2017) Protective effects of cervus Nippon Temminck Velvet antler polypeptides against MPP+\u2013induced cytotoxicity in SH\u2013SY5Y neuroblastoma cells. Mol Med Rep 16:5143\u20135150. https:\/\/doi.org\/10.3892\/mmr.2017.7303","journal-title":"Mol Med Rep"},{"key":"4388_CR49","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.neuroscience.2018.02.027","volume":"379","author":"CA Kelm-Nelson","year":"2018","unstructured":"Kelm-Nelson CA, Trevino MA, Ciucci MR (2018) Quantitative analysis of catecholamines in the Pink1 -\/- rat model of Early-onset Parkinson\u2019s disease. Neuroscience 379:126\u2013141. https:\/\/doi.org\/10.1016\/j.neuroscience.2018.02.027","journal-title":"Neuroscience"},{"key":"4388_CR50","doi-asserted-by":"publisher","unstructured":"Buccellato FR, D\u2019Anca M, Serpente M, Arighi A, Galimberti D (2022) The Role of Glymphatic System in Alzheimer\u2019s and Parkinson\u2019s Disease Pathogenesis. Biomedicines 10. https:\/\/doi.org\/10.3390\/biomedicines10092261","DOI":"10.3390\/biomedicines10092261"},{"key":"4388_CR51","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/s41531-022-00437-1","volume":"8","author":"T Shen","year":"2022","unstructured":"Shen T, Yue Y, Ba F, He T, Tang X, Hu X, Pu J, Huang C, Lv W, Zhang B, Lai HY (2022) Diffusion along perivascular spaces as marker for impairment of glymphatic system in Parkinson\u2019s disease. NPJ Parkinsons Dis 8:174. https:\/\/doi.org\/10.1038\/s41531-022-00437-1","journal-title":"NPJ Parkinsons Dis"},{"key":"4388_CR52","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s42466-021-00102-7","volume":"3","author":"I Silva","year":"2021","unstructured":"Silva I, Silva J, Ferreira R, Trigo D (2021) Glymphatic system, AQP4, and their implications in Alzheimer\u2019s disease. Neurol Res Pract 3:5. https:\/\/doi.org\/10.1186\/s42466-021-00102-7","journal-title":"Neurol Res Pract"},{"key":"4388_CR53","doi-asserted-by":"publisher","unstructured":"Lapshina KV, Ekimova IV (2024) Aquaporin-4 and Parkinson\u2019s Disease. Int J Mol Sci 25. https:\/\/doi.org\/10.3390\/ijms25031672","DOI":"10.3390\/ijms25031672"},{"key":"4388_CR54","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1007\/s12035-023-03212-2","volume":"60","author":"Y Zhang","year":"2023","unstructured":"Zhang Y, Zhang C, He XZ, Li ZH, Meng JC, Mao RT, Li X, Xue R, Gui Q, Zhang GX, Wang LH (2023) Interaction between the glymphatic system and alpha-Synuclein in Parkinson\u2019s disease. Mol Neurobiol 60:2209\u20132222. https:\/\/doi.org\/10.1007\/s12035-023-03212-2","journal-title":"Mol Neurobiol"},{"key":"4388_CR55","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1007\/s12031-021-01836-4","volume":"71","author":"H Cui","year":"2021","unstructured":"Cui H, Wang W, Zheng X, Xia D, Liu H, Qin C, Tian H, Teng J (2021) Decreased AQP4 expression aggravates a-Synuclein pathology in Parkinson\u2019s disease mice, possibly via impaired glymphatic clearance. J Mol Neurosci 71:2500\u20132513. https:\/\/doi.org\/10.1007\/s12031-021-01836-4","journal-title":"J Mol Neurosci"},{"key":"4388_CR56","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jare.2023.03.004","volume":"56","author":"X Si","year":"2024","unstructured":"Si X, Dai S, Fang Y, Tang J, Wang Z, Li Y, Song Z, Chen Y, Liu Y, Zhao G, Zhang B, Pu J (2024) Matrix metalloproteinase-9 Inhibition prevents aquaporin-4 depolarization-mediated glymphatic dysfunction in Parkinson\u2019s disease. J Adv Res 56:125\u2013136. https:\/\/doi.org\/10.1016\/j.jare.2023.03.004","journal-title":"J Adv Res"},{"key":"4388_CR57","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1177\/0271678X221098145","volume":"42","author":"G Li","year":"2022","unstructured":"Li G, Cao Y, Tang X, Huang J, Cai L, Zhou L (2022) The meningeal lymphatic vessels and the glymphatic system: potential therapeutic targets in neurological disorders. J Cereb Blood Flow Metab 42:1364\u20131382. https:\/\/doi.org\/10.1177\/0271678X221098145","journal-title":"J Cereb Blood Flow Metab"},{"key":"4388_CR58","doi-asserted-by":"publisher","unstructured":"Pajares M, A IR, Manda G, Bosca L, Cuadrado A (2020) Inflammation in Parkinson\u2019s Disease: Mechanisms and Therapeutic Implications. Cells 9. https:\/\/doi.org\/10.3390\/cells9071687","DOI":"10.3390\/cells9071687"},{"key":"4388_CR59","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1038\/s41577-022-00684-6","volume":"22","author":"MG Tansey","year":"2022","unstructured":"Tansey MG, Wallings RL, Houser MC, Herrick MK, Keating CE, Joers V (2022) Inflammation and immune dysfunction in Parkinson disease. Nat Rev Immunol 22:657\u2013673. https:\/\/doi.org\/10.1038\/s41577-022-00684-6","journal-title":"Nat Rev Immunol"},{"key":"4388_CR60","doi-asserted-by":"publisher","first-page":"2661","DOI":"10.4103\/1673-5374.391312","volume":"19","author":"K Zou","year":"2024","unstructured":"Zou K, Deng Q, Zhang H, Huang C (2024) Glymphatic system: a gateway for neuroinflammation. Neural Regen Res 19:2661\u20132672. https:\/\/doi.org\/10.4103\/1673-5374.391312","journal-title":"Neural Regen Res"},{"key":"4388_CR61","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1007\/s12035-023-03636-w","volume":"61","author":"X Li","year":"2024","unstructured":"Li X, Xie Z, Zhou Q, Tan X, Meng W, Pang Y, Huang L, Ding Z, Hu Y, Li R, Huang G, Li H (2024) TGN-020 alleviate inflammation and apoptosis after cerebral Ischemia-Reperfusion injury in mice through glymphatic and ERK1\/2 signaling pathway. Mol Neurobiol 61:1175\u20131186. https:\/\/doi.org\/10.1007\/s12035-023-03636-w","journal-title":"Mol Neurobiol"},{"key":"4388_CR62","doi-asserted-by":"publisher","first-page":"106426","DOI":"10.1016\/j.nbd.2024.106426","volume":"192","author":"Y Cai","year":"2024","unstructured":"Cai Y, Zhang Y, Leng S, Ma Y, Jiang Q, Wen Q, Ju S, Hu J (2024) The relationship between inflammation, impaired glymphatic system, and neurodegenerative disorders: A vicious cycle. Neurobiol Dis 192:106426. https:\/\/doi.org\/10.1016\/j.nbd.2024.106426","journal-title":"Neurobiol Dis"},{"key":"4388_CR63","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.1080\/15548627.2019.1596481","volume":"15","author":"X Han","year":"2019","unstructured":"Han X, Sun S, Sun Y, Song Q, Zhu J, Song N, Chen M, Sun T, Xia M, Ding J, Lu M, Yao H, Hu G (2019) Small molecule-driven NLRP3 inflammation Inhibition via interplay between ubiquitination and autophagy: implications for Parkinson disease. Autophagy 15:1860\u20131881. https:\/\/doi.org\/10.1080\/15548627.2019.1596481","journal-title":"Autophagy"},{"key":"4388_CR64","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12974-019-1538-9","volume":"16","author":"M Zusso","year":"2019","unstructured":"Zusso M, Lunardi V, Franceschini D, Pagetta A, Lo R, Stifani S, Frigo AC, Giusti P, Moro S (2019) Ciprofloxacin and Levofloxacin attenuate microglia inflammatory response via TLR4\/NF-kB pathway. J Neuroinflammation 16:148. https:\/\/doi.org\/10.1186\/s12974-019-1538-9","journal-title":"J Neuroinflammation"},{"key":"4388_CR65","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41586-018-0372-z","volume":"560","author":"Z Zhong","year":"2018","unstructured":"Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M (2018) New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature 560:198\u2013203. https:\/\/doi.org\/10.1038\/s41586-018-0372-z","journal-title":"Nature"},{"key":"4388_CR66","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","volume":"13","author":"T Kawai","year":"2007","unstructured":"Kawai T, Akira S (2007) Signaling to NF-kappaB by Toll-like receptors. Trends Mol Med 13:460\u2013469. https:\/\/doi.org\/10.1016\/j.molmed.2007.09.002","journal-title":"Trends Mol Med"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-025-04388-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-025-04388-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-025-04388-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:00:19Z","timestamp":1745553619000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-025-04388-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":66,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["4388"],"URL":"https:\/\/doi.org\/10.1007\/s11064-025-04388-w","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"27 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 April 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}],"article-number":"142"}}