{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:31:58Z","timestamp":1784140318531,"version":"3.55.0"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas","doi-asserted-by":"publisher","award":["PhD Fellowship 290749"],"award-info":[{"award-number":["PhD Fellowship 290749"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["PhD Fellowship"],"award-info":[{"award-number":["PhD Fellowship"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["PhD Fellowship"],"award-info":[{"award-number":["PhD Fellowship"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["426342\/2018-6; PQ 2 Fellowship"],"award-info":[{"award-number":["426342\/2018-6; PQ 2 Fellowship"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["PhD Fellowship"],"award-info":[{"award-number":["PhD Fellowship"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["No E-26\/202.668\/2018"],"award-info":[{"award-number":["No E-26\/202.668\/2018"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["No E-26\/202.668\/2018"],"award-info":[{"award-number":["No E-26\/202.668\/2018"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007384","name":"Instituto Nacional de Ci\u00eancia e Tecnologia de Neuroci\u00eancia Translacional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007384","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1007\/s11064-025-04500-0","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T17:17:19Z","timestamp":1753118239000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Extracellular Matrix Proteins Differentiate Postnatal Mouse Retina Neurospheres into Neurons or Glia Profiles"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2768-0002","authenticated-orcid":false,"given":"Orquidia Guadalupe","family":"M\u00e9ndez-Flores","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6337-2665","authenticated-orcid":false,"given":"Anna Carolina Rego","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3914-4549","authenticated-orcid":false,"given":"Andrey Fabiano Louren\u00e7o","family":"de Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9275-1175","authenticated-orcid":false,"given":"Yolanda","family":"Paes-Colli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7744-5372","authenticated-orcid":false,"given":"Cl\u00e1udia Maria","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1135-4149","authenticated-orcid":false,"given":"Victor T.","family":"Ribeiro-Resende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9594-8114","authenticated-orcid":false,"given":"Arturo","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9689-4085","authenticated-orcid":false,"given":"Ricardo A.","family":"de Melo Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"4500_CR1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0959-4388(99)80005-1","volume":"9","author":"CL Cepko","year":"1999","unstructured":"Cepko CL (1999) The roles of intrinsic and extrinsic cues and bHLH genes in the determination of retinal cell fates. Curr Opin Neurobiol 9:37\u201346","journal-title":"Curr Opin Neurobiol"},{"key":"4500_CR2","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/328131a0","volume":"328","author":"DL Turner","year":"1987","unstructured":"Turner DL, Cepko CL (1987) A common progenitor for neurons and glia persists in rat retina late in development. Nature 328:131\u2013136","journal-title":"Nature"},{"issue":"2","key":"4500_CR3","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.3390\/ijms25021120","volume":"25","author":"MH Tempone","year":"2024","unstructured":"Tempone MH, Borges-Martins VP, C\u00e9sar F, Alexandrino-Mattos DP, de Figueiredo CS, Raony \u00cd, Dos Santos AA, Duarte-Silva AT, Dias MS, Freitas HR, de Ara\u00fajo EG (2024) The healthy and diseased retina seen through neuron\u2013glia interactions. Int J Mol Sci 25(2):1120","journal-title":"Int J Mol Sci"},{"key":"4500_CR4","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1146\/annurev.cellbio.042308.113259","volume":"25","author":"M Agathocleous","year":"2009","unstructured":"Agathocleous M, Harris WA (2009) From progenitors to differentiated cells in the vertebrate retina. Annu Rev Cell Dev Biol 25:45\u201369","journal-title":"Annu Rev Cell Dev Biol"},{"key":"4500_CR5","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1634\/stemcells.2008-0222","volume":"26","author":"S Bhattacharya","year":"2008","unstructured":"Bhattacharya S, Das AV, Mallya KB, Ahmad I (2008) Ciliary neurotrophic factor-mediated signaling regulates neuronal versus glial differentiation of retinal stem cells\/progenitors by concentration-dependent recruitment of mitogen-activated protein kinase and Janus kinase-signal transducer and activator of transcription pathways in conjunction with Notch signaling. Stem cells 26:2611\u20132624","journal-title":"Stem cells"},{"key":"4500_CR6","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1007\/s10571-011-9673-6","volume":"31","author":"RA De Melo Reis","year":"2011","unstructured":"De Melo Reis RA, Schitine CS, K\u00f6falvi A, Grade S, Cortes L, Gardino PF, Malva JO, de Mello FG (2011) Functional identification of cell phenotypes differentiating from mice retinal neurospheres using single cell calcium imaging. Cell Mol Neurobiol 31:835\u2013846","journal-title":"Cell Mol Neurobiol"},{"key":"4500_CR7","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0736-5748(02)00040-0","volume":"20","author":"MM Sobeih","year":"2002","unstructured":"Sobeih MM, Corfas G (2002) Extracellular factors that regulate neuronal migration in the central nervous system. Int J Dev Neurosci: Off J Int Soc Dev Neurosci 20:349\u2013357","journal-title":"Int J Dev Neurosci: Off J Int Soc Dev Neurosci"},{"key":"4500_CR8","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s00418-008-0485-9","volume":"130","author":"DR Zimmermann","year":"2008","unstructured":"Zimmermann DR, Dours-Zimmermann MT (2008) Extracellular matrix of the central nervous system: from neglect to challenge. Histochem Cell Biol 130:635\u2013653","journal-title":"Histochem Cell Biol"},{"key":"4500_CR9","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.1242\/jcs.023820","volume":"123","author":"C Frantz","year":"2010","unstructured":"Frantz C, Stewart KM, Weaver VM (2010) The extracellular matrix at a glance. J Cell Sci 123:4195\u20134200","journal-title":"J Cell Sci"},{"key":"4500_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2015.06.003","volume":"51","author":"E Vecino","year":"2016","unstructured":"Vecino E, Rodriguez FD, Ruzafa N, Pereiro X, Sharma SC (2016) Glia-neuron interactions in the mammalian retina. Prog Retin Eye Res 51:1\u201340","journal-title":"Prog Retin Eye Res"},{"key":"4500_CR11","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1242\/dev.119.4.1079","volume":"119","author":"EL George","year":"1993","unstructured":"George EL, Georges-Labouesse EN, Patel-King RS, Rayburn H, Hynes RO (1993) Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. Development 119:1079\u20131091","journal-title":"Development"},{"key":"4500_CR12","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.matbio.2011.09.002","volume":"31","author":"N Ichikawa-Tomikawa","year":"2012","unstructured":"Ichikawa-Tomikawa N, Ogawa J, Douet V, Xu Z, Kamikubo Y, Sakurai T, Kohsaka S, Chiba H, Hattori N, Yamada Y, Arikawa-Hirasawa E (2012) Laminin \u03b11 is essential for mouse cerebellar development. Matrix Biol: J Int Soc Matrix Biol 31:17\u201328","journal-title":"Matrix Biol: J Int Soc Matrix Biol"},{"key":"4500_CR13","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/j.tcb.2019.10.001","volume":"29","author":"L Yap","year":"2019","unstructured":"Yap L, Tay HG, Nguyen MTX, Tjin MS, Tryggvason K (2019) Laminins in Cellular Differentiation. Trends Cell Biol 29:987\u20131000","journal-title":"Trends Cell Biol"},{"key":"4500_CR14","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1242\/dev.128.9.1481","volume":"128","author":"S Pons","year":"2001","unstructured":"Pons S, Trejo JL, Mart\u00ednez-Morales JR, Mart\u00ed E (2001) Vitronectin regulates Sonic hedgehog activity during cerebellum development through CREB phosphorylation. Development 128:1481\u20131492","journal-title":"Development"},{"key":"4500_CR15","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/S0014-4886(03)00124-9","volume":"182","author":"SM Kearns","year":"2003","unstructured":"Kearns SM, Laywell ED, Kukekov VK, Steindler DA (2003) Extracellular matrix effects on neurosphere cell motility. Exp Neurol 182:240\u2013244","journal-title":"Exp Neurol"},{"key":"4500_CR16","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1523\/JNEUROSCI.15-02-01110.1995","volume":"15","author":"H Komuro","year":"1995","unstructured":"Komuro H, Rakic P (1995) Dynamics of granule cell migration: a confocal microscopic study in acute cerebellar slice preparations. J Neurosci: Off J Soc Neurosci 15:1110\u20131120","journal-title":"J Neurosci: Off J Soc Neurosci"},{"key":"4500_CR17","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/39878","volume":"389","author":"ML Condic","year":"1997","unstructured":"Condic ML, Letourneau PC (1997) Ligand-induced changes in integrin expression regulate neuronal adhesion and neurite outgrowth. Nature 389:852\u2013856","journal-title":"Nature"},{"key":"4500_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2021.108545","volume":"206","author":"KY Zhang","year":"2021","unstructured":"Zhang KY, Johnson TV (2021) The internal limiting membrane: Roles in retinal development and implications for emerging ocular therapies. Exp Eye Res 206:108545","journal-title":"Exp Eye Res"},{"key":"4500_CR19","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1002\/glia.22839","volume":"63","author":"A Faissner","year":"2015","unstructured":"Faissner A, Reinhard J (2015) The extracellular matrix compartment of neural stem and glial progenitor cells. Glia 63:1330\u20131349","journal-title":"Glia"},{"key":"4500_CR20","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.exer.2014.07.001","volume":"133","author":"J Reinhard","year":"2015","unstructured":"Reinhard J, Joachim SC, Faissner A (2015) Extracellular matrix remodeling during retinal development. Exp Eye Res 133:132\u2013140","journal-title":"Exp Eye Res"},{"issue":"1","key":"4500_CR21","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s004170100351","volume":"240","author":"X Li","year":"2002","unstructured":"Li X, Shi X, Fan J (2002) Posterior vitreous detachment with plasmin in the isolated human eye. Graefe\u2019s Arch Clin Exp Ophthalmol 240(1):56\u201362","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol"},{"key":"4500_CR22","doi-asserted-by":"publisher","first-page":"d723","DOI":"10.2741\/1020","volume":"8","author":"DO Clegg","year":"2003","unstructured":"Clegg DO, Wingerd KL, Hikita ST, Tolhurst EC (2003) Integrins in the development, function and dysfunction of the nervous system. Front Biosci 8:d723","journal-title":"Front Biosci"},{"key":"4500_CR23","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0031-6997(24)01359-0","volume":"50","author":"AE Aplin","year":"1998","unstructured":"Aplin AE, Howe A, Alahari SK, Juliano RL (1998) Signal transduction and signal modulation by cell adhesion receptors: the role of integrins, cadherins, immunoglobulin-cell adhesion molecules, and selectins. Pharmacol Rev 50:197\u2013263","journal-title":"Pharmacol Rev"},{"key":"4500_CR24","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/jnr.10321","volume":"69","author":"R Milner","year":"2002","unstructured":"Milner R, Campbell IL (2002) The integrin family of cell adhesion molecules has multiple functions within the CNS. J Neurosci Res 69:286\u2013291","journal-title":"J Neurosci Res"},{"key":"4500_CR25","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1016\/j.ejcb.2005.09.017","volume":"84","author":"C Andressen","year":"2005","unstructured":"Andressen C, Adrian S, F\u00e4ssler R, Arnhold S, Addicks K (2005) The contribution of beta1 integrins to neuronal migration and differentiation depends on extracellular matrix molecules. Eur J Cell Biol 84:973\u2013982","journal-title":"Eur J Cell Biol"},{"key":"4500_CR26","doi-asserted-by":"publisher","first-page":"4451","DOI":"10.1242\/dev.071381","volume":"138","author":"D Stenzel","year":"2011","unstructured":"Stenzel D, Lundkvist A, Sauvaget D, Busse M, Graupera M, van der Flier A, Wijelath ES, Murray J, Sobel M, Costell M, Takahashi S, F\u00e4ssler R, Yamaguchi Y, Gutmann DH, Hynes RO, Gerhardt H (2011) Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis. Development 138:4451\u20134463","journal-title":"Development"},{"issue":"Pt 9","key":"4500_CR27","doi-asserted-by":"publisher","first-page":"2499","DOI":"10.1242\/jcs.107.9.2499","volume":"107","author":"B Jiang","year":"1994","unstructured":"Jiang B, Liou GI, Behzadian MA, Caldwell RB (1994) Astrocytes modulate retinal vasculogenesis: effects on fibronectin expression. J Cell Sci 107(Pt 9):2499\u20132508","journal-title":"J Cell Sci"},{"key":"4500_CR28","first-page":"76","volume":"12","author":"AG Wang","year":"2006","unstructured":"Wang AG, Yen MY, Hsu WM, Fann MJ (2006) Induction of vitronectin and integrin alphav in the retina after optic nerve injury. Mol Vis 12:76\u201384","journal-title":"Mol Vis"},{"key":"4500_CR29","doi-asserted-by":"publisher","first-page":"410","DOI":"10.3389\/fncel.2018.00410","volume":"12","author":"RPM Guimar\u00e3es","year":"2018","unstructured":"Guimar\u00e3es RPM, Landeira BS, Coelho DM, Golbert DCF, Silveira MS, Linden R, de Melo Reis RA, Costa MR (2018) Evidence of M\u00fcller glia conversion into retina ganglion cells using neurogenin2. Front Cell Neurosci 12:410","journal-title":"Front Cell Neurosci"},{"key":"4500_CR30","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.4103\/1673-5374.165224","volume":"10","author":"CS Schitine","year":"2015","unstructured":"Schitine CS, de Mello FG, Reis RA (2015) Neurochemical plasticity of M\u00fcller cells after retinal injury: overexpression of GAT-3 may potentiate excitotoxicity. Neural Regen Res 10:1376\u20131378","journal-title":"Neural Regen Res"},{"key":"4500_CR31","doi-asserted-by":"publisher","first-page":"617","DOI":"10.3390\/antiox11040617","volume":"11","author":"R Carpi-Santos","year":"2022","unstructured":"Carpi-Santos R, de Melo Reis RA, Gomes FCA, Calaza KC (2022) Contribution of M\u00fcller cells in the diabetic retinopathy development: focus on oxidative stress and inflammation. Antioxidants 11:617","journal-title":"Antioxidants"},{"key":"4500_CR32","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.569361","volume":"14","author":"RA de Melo Reis","year":"2020","unstructured":"de Melo Reis RA, Freitas HR, de Mello FG (2020) Cell calcium imaging as a reliable method to study neuron-glial circuits. Front Neurosci 14:569361","journal-title":"Front Neurosci"},{"key":"4500_CR33","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/s10571-018-0636-z","volume":"39","author":"BR da Silva","year":"2019","unstructured":"da Silva BR, Santos LE, de Melo Reis RA, de Mello FG, Ribeiro-Resende VT (2019) M\u00fcller cells derived from adult chicken and mouse retina neurospheres acquire the dopaminergic phenotype. Cell Mol Neurobiol 39:99\u2013109","journal-title":"Cell Mol Neurobiol"},{"key":"4500_CR34","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1113\/jphysiol.2007.148353","volume":"586","author":"BL Bloodgood","year":"2008","unstructured":"Bloodgood BL, Sabatini BL (2008) Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels. J Physiol 586:1475\u20131480","journal-title":"J Physiol"},{"key":"4500_CR35","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s10863-017-9717-9","volume":"49","author":"RX Faria","year":"2017","unstructured":"Faria RX, Freitas HR, Reis RAM (2017) P2X7 receptor large pore signaling in avian M\u00fcller glial cells. J Bioenerg Biomembr 49:215\u2013229","journal-title":"J Bioenerg Biomembr"},{"key":"4500_CR36","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1002\/glia.20352","volume":"54","author":"MR Metea","year":"2006","unstructured":"Metea MR, Newman EA (2006) Calcium signaling in specialized glial cells. Glia 54:650\u2013655","journal-title":"Glia"},{"key":"4500_CR37","doi-asserted-by":"publisher","first-page":"175909142097480","DOI":"10.1177\/1759091420974807","volume":"12","author":"KDA Rienecker","year":"2020","unstructured":"Rienecker KDA, Poston RG, Saha RN (2020) Merits and limitations of studying neuronal depolarization-dependent processes using elevated external potassium. ASN Neuro 12:1759091420974807","journal-title":"ASN Neuro"},{"key":"4500_CR38","doi-asserted-by":"publisher","first-page":"27","DOI":"10.3389\/fnmol.2011.00027","volume":"4","author":"JS Diamond","year":"2011","unstructured":"Diamond JS (2011) Calcium-permeable AMPA receptors in the retina. Front Mol Neurosci 4:27","journal-title":"Front Mol Neurosci"},{"key":"4500_CR39","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.neuron.2019.09.026","volume":"104","author":"N Urb\u00e1n","year":"2019","unstructured":"Urb\u00e1n N, Blomfield IM, Guillemot F (2019) Quiescence of adult mammalian neural stem cells: a highly regulated rest. Neuron 104:834\u2013848","journal-title":"Neuron"},{"key":"4500_CR40","doi-asserted-by":"publisher","first-page":"1707","DOI":"10.1126\/science.1553558","volume":"255","author":"BA Reynolds","year":"1992","unstructured":"Reynolds BA, Weiss S (1992) Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system. Science 255:1707\u20131710","journal-title":"Science"},{"key":"4500_CR41","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.1007\/s11033-021-06301-4","volume":"48","author":"SL da Silva","year":"2021","unstructured":"da Silva SL, Majolo F, da Silva APB, da Costa JC, Marinowic DR (2021) Neurospheres: a potential in vitro model for the study of central nervous system disorders. Mol Biol Rep 48:3649\u20133663","journal-title":"Mol Biol Rep"},{"key":"4500_CR42","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1016\/j.stem.2015.09.003","volume":"17","author":"AM Bond","year":"2015","unstructured":"Bond AM, Ming GL, Song H (2015) Adult mammalian neural stem cells and neurogenesis: five decades later. Cell Stem Cell 17:385\u2013395","journal-title":"Cell Stem Cell"},{"key":"4500_CR43","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.cell.2016.10.021","volume":"167","author":"JT Gon\u00e7alves","year":"2016","unstructured":"Gon\u00e7alves JT, Schafer ST, Gage FH (2016) Adult neurogenesis in the hippocampus: from stem cells to behavior. Cell 167:897\u2013914","journal-title":"Cell"},{"key":"4500_CR44","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1089\/scd.2013.0177","volume":"23","author":"L Balenci","year":"2014","unstructured":"Balenci L, van der Kooy D (2014) Notch signaling induces retinal stem-like properties in perinatal neural retina progenitors and promotes symmetric divisions in adult retinal stem cells. Stem Cells Dev 23:230\u2013244","journal-title":"Stem Cells Dev"},{"key":"4500_CR45","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1111\/j.1460-9568.2012.08072.x","volume":"35","author":"C Schitine","year":"2012","unstructured":"Schitine C, Xapelli S, Agasse F, Sard\u00e0-Arroyo L, Silva AP, De Melo Reis RA, de Mello FG, Malva JO (2012) Ampakine CX546 increases proliferation and neuronal differentiation in subventricular zone stem\/progenitor cell cultures. Eur J Neurosci 35:1672\u20131683","journal-title":"Eur J Neurosci"},{"key":"4500_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063529","volume":"8","author":"S Xapelli","year":"2013","unstructured":"Xapelli S, Agasse F, Sard\u00e0-Arroyo L, Bernardino L, Santos T, Ribeiro FF, Valero J, Bragan\u00e7a J, Schitine C, de Melo Reis RA, Sebasti\u00e3o AM, Malva JO (2013) Activation of type 1 cannabinoid receptor (CB1R) promotes neurogenesis in murine subventricular zone cell cultures. PLoS ONE 8:e63529","journal-title":"PLoS ONE"},{"key":"4500_CR47","doi-asserted-by":"publisher","first-page":"59","DOI":"10.3389\/fncel.2014.00059","volume":"8","author":"S Xapelli","year":"2014","unstructured":"Xapelli S, Agasse F, Grade S, Bernardino L, Ribeiro FF, Schitine CS, Heimann AS, Ferro ES, Sebasti\u00e3o AM, De Melo Reis RA, Malva JO (2014) Modulation of subventricular zone oligodendrogenesis: a role for hemopressin? Front Cell Neurosci 8:59","journal-title":"Front Cell Neurosci"},{"key":"4500_CR48","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1111\/jnc.12084","volume":"124","author":"GC Bellenchi","year":"2013","unstructured":"Bellenchi GC, Volpicelli F, Piscopo V, Perrone-Capano C, di Porzio U (2013) Adult neural stem cells: an endogenous tool to repair brain injury? J Neurochem 124:159\u2013167","journal-title":"J Neurochem"},{"key":"4500_CR49","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1517\/14712598.8.2.153","volume":"8","author":"L Conti","year":"2008","unstructured":"Conti L, Cattaneo E, Papadimou E (2008) Novel neural stem cell systems. Expert Opin Biol Ther 8:153\u2013160","journal-title":"Expert Opin Biol Ther"},{"key":"4500_CR50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000163","volume":"17","author":"S Bahrampour","year":"2019","unstructured":"Bahrampour S, Jonsson C, Thor S (2019) Brain expansion promoted by polycomb-mediated anterior enhancement of a neural stem cell proliferation program. PLoS Biol 17:e3000163","journal-title":"PLoS Biol"},{"key":"4500_CR51","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.biomaterials.2015.09.020","volume":"73","author":"Y Yan","year":"2015","unstructured":"Yan Y, Martin LM, Bosco DB, Bundy JL, Nowakowski RS, Sang QX, Li Y (2015) Differential effects of acellular embryonic matrices on pluripotent stem cell expansion and neural differentiation. Biomaterials 73:231\u2013242","journal-title":"Biomaterials"},{"key":"4500_CR52","doi-asserted-by":"publisher","first-page":"10354","DOI":"10.1038\/ncomms10354","volume":"7","author":"K Long","year":"2016","unstructured":"Long K, Moss L, Laursen L, Boulter L, Ffrench-Constant C (2016) Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. Nat Commun 7:10354","journal-title":"Nat Commun"},{"key":"4500_CR53","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/B978-0-444-63486-3.00001-3","volume":"214","author":"U Theocharidis","year":"2014","unstructured":"Theocharidis U, Long K, French-Constant C, Faissner A (2014) Regulation of the neural stem cell compartment by extracellular matrix constituents. Prog Brain Res 214:3\u201328","journal-title":"Prog Brain Res"},{"key":"4500_CR54","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/0306-4522(91)90267-R","volume":"45","author":"B Chamak","year":"1991","unstructured":"Chamak B, Mallat M (1991) Fibronectin and laminin regulate the in vitro differentiation of microglial cells. Neuroscience 45:513\u2013527","journal-title":"Neuroscience"},{"key":"4500_CR55","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1093\/brain\/aws313","volume":"136","author":"JM Stoffels","year":"2013","unstructured":"Stoffels JM, de Jonge JC, Stancic M, Nomden A, van Strien ME, Ma D, Siskov\u00e1 Z, Maier O, Ffrench-Constant C, Franklin RJ, Hoekstra D, Zhao C, Baron W (2013) Fibronectin aggregation in multiple sclerosis lesions impairs remyelination. Brain 136:116\u2013131","journal-title":"Brain"},{"key":"4500_CR56","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s12974-018-1238-x","volume":"15","author":"AH Sikkema","year":"2018","unstructured":"Sikkema AH, Stoffels JMJ, Wang P, Basedow FJ, Bulsink R, Bajramovic JJ, Baron W (2018) Fibronectin aggregates promote features of a classically and alternatively activated phenotype in macrophages. J Neuroinflammation 15:218","journal-title":"J Neuroinflammation"},{"key":"4500_CR57","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.135648","volume":"746","author":"Y Oishi","year":"2021","unstructured":"Oishi Y, Hashimoto K, Abe A, Kuroda M, Fujii A, Miyamoto Y (2021) Vitronectin regulates the axon specification of mouse cerebellar granule cell precursors via \u03b1v\u03b25 integrin in the differentiation stage. Neurosci Lett 746:135648","journal-title":"Neurosci Lett"},{"key":"4500_CR58","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/0306-4522(95)00089-2","volume":"68","author":"JR Mart\u00ednez-Morales","year":"1995","unstructured":"Mart\u00ednez-Morales JR, Mart\u00ed E, Frade JM, Rodr\u00edguez-T\u00e9bar A (1995) Developmentally regulated vitronectin influences cell differentiation, neuron survival and process outgrowth in the developing chicken retina. Neuroscience 68:245\u2013253","journal-title":"Neuroscience"},{"key":"4500_CR59","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1177\/0885328214547751","volume":"29","author":"E Lawley","year":"2015","unstructured":"Lawley E, Baranov P, Young M (2015) Hybrid vitronectin-mimicking polycaprolactone scaffolds for human retinal progenitor cell differentiation and transplantation. J Biomater Appl 29:894\u2013902","journal-title":"J Biomater Appl"},{"key":"4500_CR60","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.actbio.2016.10.037","volume":"48","author":"D Varun","year":"2017","unstructured":"Varun D, Srinivasan GR, Tsai YH, Kim HJ, Cutts J, Petty F, Merkley R, Stephanopoulos N, Dolezalova D, Marsala M, Brafman DA (2017) A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs). Acta Biomater 48:120\u2013130","journal-title":"Acta Biomater"},{"key":"4500_CR61","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.ceca.2005.01.005","volume":"37","author":"SE Webb","year":"2005","unstructured":"Webb SE, Moreau M, Leclerc C, Miller AL (2005) Calcium transients and neural induction in vertebrates. Cell Calcium 37:375\u2013385","journal-title":"Cell Calcium"},{"key":"4500_CR62","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1007\/s11064-011-0422-5","volume":"36","author":"J Aruga","year":"2011","unstructured":"Aruga J, Mikoshiba K (2011) Role of BMP, FGF, calcium signaling, and Zic proteins in vertebrate neuroectodermal differentiation. Neurochem Res 36:1286\u20131292","journal-title":"Neurochem Res"},{"key":"4500_CR63","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ceca.2016.01.004","volume":"59","author":"B Hao","year":"2016","unstructured":"Hao B, Webb SE, Miller AL, Yue J (2016) The role of Ca(2+) signaling on the self-renewal and neural differentiation of embryonic stem cells (ESCs). Cell Calcium 59:67\u201374","journal-title":"Cell Calcium"},{"key":"4500_CR64","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1002\/stem.2522","volume":"35","author":"K Zelentsova","year":"2017","unstructured":"Zelentsova K, Talmi Z, Abboud-Jarrous G, Sapir T, Capucha T, Nassar M, Burstyn-Cohen T (2017) Protein S regulates neural stem cell quiescence and neurogenesis. Stem cells 35:679\u2013693","journal-title":"Stem cells"},{"key":"4500_CR65","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1016\/j.neuron.2011.05.018","volume":"71","author":"RA Ihrie","year":"2011","unstructured":"Ihrie RA, Shah JK, Harwell CC, Levine JH, Guinto CD, Lezameta M, Kriegstein AR, Alvarez-Buylla A (2011) Persistent sonic hedgehog signaling in adult brain determines neural stem cell positional identity. Neuron 71:250\u2013262","journal-title":"Neuron"},{"key":"4500_CR66","first-page":"371","volume-title":"Intertwining extracellular nucleotides and their receptors with Ca2+ in determining adult neural stem cell survival, proliferation and final fate","author":"D Lecca","year":"2016","unstructured":"Lecca D, Fumagalli M, Ceruti S, Abbracchio MP (2016) Intertwining extracellular nucleotides and their receptors with Ca2+ in determining adult neural stem cell survival, proliferation and final fate. Philosophical transactions of the Royal Society of London Series B, Biological sciences, p 371"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-025-04500-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-025-04500-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-025-04500-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T16:56:13Z","timestamp":1757264173000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-025-04500-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,21]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["4500"],"URL":"https:\/\/doi.org\/10.1007\/s11064-025-04500-0","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,21]]},"assertion":[{"value":"14 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}],"article-number":"242"}}