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This review is focusing on the multifaceted role of astrocytic\n                    <jats:sc>d<\/jats:sc>\n                    -serine from synaptic transmission to cognitive processes. While this review includes the work of other groups, it is mainly based on the findings obtained in our laboratory. Drawing from two decades of research spanning from the hypothalamus to the hippocampus, we here highlight how astrocyte-derived\n                    <jats:sc>d<\/jats:sc>\n                    -serine regulates NMDAR activity, long-term synaptic plasticity, and associated memory. Our findings have revealed the dynamic control exerted by astrocytic processes onto\n                    <jats:sc>d<\/jats:sc>\n                    -serine availability within the synaptic cleft, including the impact of the astrocytic morphological plasticity, the key role played by intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    as well as the involvement of CB1 and EphB3 receptors. We also discuss how an impairment in astrocytic\n                    <jats:sc>d<\/jats:sc>\n                    -serine synthesis can affect the co-agonist availability and consequently impact cognitive functions in neurodegenerative disorders such as Alzheimer\u2019s Disease. To conclude, this review highlights the role of astrocytic\n                    <jats:sc>d<\/jats:sc>\n                    -serine in astrocyte-neuron communication and higher-order brain functions.\n                  <\/jats:p>","DOI":"10.1007\/s11064-025-04564-y","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:45:44Z","timestamp":1760427944000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["d-Serine\u2019s Journey Between Stars and Synapses"],"prefix":"10.1007","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1368-7086","authenticated-orcid":false,"given":"Sarah","family":"Mountadem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0595-9029","authenticated-orcid":false,"given":"St\u00e9phane Henri Richard","family":"Oliet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6107-4463","authenticated-orcid":false,"given":"Aude","family":"Panatier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,14]]},"reference":[{"issue":"6","key":"4564_CR1","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/S0301-0082(00)00029-0","volume":"62","author":"G Carmignoto","year":"2000","unstructured":"Carmignoto G (2000) Reciprocal communication systems between astrocytes and neurones. 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