{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:46:03Z","timestamp":1786981563724,"version":"build-2736575974"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s11064-025-04622-5","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T09:01:44Z","timestamp":1764406904000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ciwujianoside C Attenuates Cerebral Ischemia-Reperfusion Injury by Suppressing Ferroptosis via NNAT-Mediated Inhibition of NF-\u03baB Signaling"],"prefix":"10.1007","volume":"51","author":[{"given":"Weichuan","family":"Dai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xieli","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"issue":"50","key":"4622_CR1","doi-asserted-by":"publisher","first-page":"e2409529","DOI":"10.1002\/adma.202409529","volume":"36","author":"S Wang","year":"2024","unstructured":"Wang S et al (2024) Inhibiting mitochondrial damage for efficient treatment of cerebral Ischemia-Reperfusion injury through sequential targeting nanomedicine of neuronal mitochondria in affected brain tissue. Adv Mater 36(50):e2409529","journal-title":"Adv Mater"},{"issue":"10","key":"4622_CR2","doi-asserted-by":"publisher","first-page":"10529","DOI":"10.1021\/acsnano.5c01434","volume":"19","author":"Z Cheng","year":"2025","unstructured":"Cheng Z et al (2025) Cascade-type microglial pyroptosis inhibitors for enhanced treatment of cerebral ischemia-reperfusion injury. ACS Nano 19(10):10529\u201310548","journal-title":"ACS Nano"},{"issue":"8","key":"4622_CR3","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/cns.12114","volume":"19","author":"CH Chen","year":"2013","unstructured":"Chen CH et al (2013) The involvement of programmed cell death 5 (PDCD5) in the regulation of apoptosis in cerebral ischemia\/reperfusion injury. CNS Neurosci Ther 19(8):566\u2013576","journal-title":"CNS Neurosci Ther"},{"key":"4622_CR4","doi-asserted-by":"publisher","first-page":"934154","DOI":"10.3389\/fgene.2022.934154","volume":"13","author":"J Shu","year":"2022","unstructured":"Shu J et al (2022) Identification of programmed cell death-related gene signature and associated regulatory axis in cerebral ischemia\/reperfusion injury. Front Genet 13:934154","journal-title":"Front Genet"},{"issue":"1","key":"4622_CR5","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41392-023-01688-x","volume":"9","author":"M Zhang","year":"2024","unstructured":"Zhang M et al (2024) Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets. Signal Transduct Target Ther 9(1):12","journal-title":"Signal Transduct Target Ther"},{"issue":"18","key":"4622_CR6","doi-asserted-by":"publisher","first-page":"18164","DOI":"10.1021\/acsnano.3c05038","volume":"17","author":"C Li","year":"2023","unstructured":"Li C et al (2023) Pleiotropic microenvironment remodeling micelles for cerebral ischemia-reperfusion injury therapy by inhibiting neuronal ferroptosis and glial overactivation. ACS Nano 17(18):18164\u201318177","journal-title":"ACS Nano"},{"key":"4622_CR7","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2024.03.019","volume":"217","author":"P Xiao","year":"2024","unstructured":"Xiao P et al (2024) Edaravone Dexborneol protects against cerebral ischemia\/reperfusion-induced blood-brain barrier damage by inhibiting ferroptosis via activation of nrf-2\/HO-1\/GPX4 signaling. Free Radic Biol Med 217:116\u2013125","journal-title":"Free Radic Biol Med"},{"key":"4622_CR8","doi-asserted-by":"publisher","first-page":"156331","DOI":"10.1016\/j.phymed.2024.156331","volume":"136","author":"C Gong","year":"2025","unstructured":"Gong C et al (2025) Gastrodin: modulating the xCT\/GPX4 and ACSL4\/LPCAT3 pathways to inhibit ferroptosis after ischemic stroke. Phytomedicine 136:156331","journal-title":"Phytomedicine"},{"issue":"1","key":"4622_CR9","doi-asserted-by":"publisher","first-page":"26330","DOI":"10.1038\/s41598-024-77574-5","volume":"14","author":"RH Kwon","year":"2024","unstructured":"Kwon RH et al (2024) Comprehensive profiling of phenolic compounds and triterpenoid saponins from acanthopanax senticosus and their antioxidant, \u03b1-glucosidase inhibitory activities. Sci Rep 14(1):26330","journal-title":"Sci Rep"},{"issue":"4","key":"4622_CR10","doi-asserted-by":"publisher","first-page":"3749","DOI":"10.3892\/mmr.2016.5710","volume":"14","author":"DH Kang","year":"2016","unstructured":"Kang DH et al (2016) Anti\u2013inflammatory effects of Ciwujianoside C3, extracted from the leaves of acanthopanax henryi (Oliv.) Harms, on LPS\u2013stimulated RAW 264.7 cells. Mol Med Rep 14(4):3749\u20133758","journal-title":"Mol Med Rep"},{"issue":"11","key":"4622_CR11","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1021\/np060195+","volume":"69","author":"W Jiang","year":"2006","unstructured":"Jiang W et al (2006) Biologically active triterpenoid saponins from acanthopanax senticosus. J Nat Prod 69(11):1577\u20131581","journal-title":"J Nat Prod"},{"issue":"1","key":"4622_CR12","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/1423-0127-17-41","volume":"17","author":"KH Chen","year":"2010","unstructured":"Chen KH et al (2010) Altered neuronatin expression in the rat dorsal root ganglion after sciatic nerve transection. J Biomed Sci 17(1):41","journal-title":"J Biomed Sci"},{"issue":"10","key":"4622_CR13","doi-asserted-by":"publisher","first-page":"2774","DOI":"10.2337\/db07-1746","volume":"57","author":"N Mzhavia","year":"2008","unstructured":"Mzhavia N et al (2008) Neuronatin: a new inflammation gene expressed on the aortic endothelium of diabetic mice. Diabetes 57(10):2774\u20132783","journal-title":"Diabetes"},{"issue":"6","key":"4622_CR14","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.4014\/jmb.1702.02049","volume":"27","author":"HI Ka","year":"2017","unstructured":"Ka HI et al (2017) Neuronatin is associated with an Anti-Inflammatory role in the white adipose tissue. J Microbiol Biotechnol 27(6):1180\u20131188","journal-title":"J Microbiol Biotechnol"},{"issue":"1","key":"4622_CR15","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1186\/s12951-024-02672-5","volume":"22","author":"G Liu","year":"2024","unstructured":"Liu G et al (2024) ZnO NPs induce miR-342-5p mediated ferroptosis of spermatocytes through the NF-\u03baB pathway in mice. J Nanobiotechnol 22(1):390","journal-title":"J Nanobiotechnol"},{"issue":"Pt 1","key":"4622_CR16","doi-asserted-by":"publisher","first-page":"135109","DOI":"10.1016\/j.ijbiomac.2024.135109","volume":"279","author":"X Zhu","year":"2024","unstructured":"Zhu X, Han X, Wang J (2024) Sufentanil-induced Nrf2 protein ameliorates cerebral ischemia-reperfusion injury through suppressing neural ferroptosis. Int J Biol Macromol 279(Pt 1):135109","journal-title":"Int J Biol Macromol"},{"key":"4622_CR17","doi-asserted-by":"publisher","first-page":"116500","DOI":"10.1016\/j.biopha.2024.116500","volume":"174","author":"J Shang","year":"2024","unstructured":"Shang J et al (2024) Chrysin inhibits ferroptosis of cerebral ischemia\/reperfusion injury via regulating HIF-1\u03b1\/CP loop. Biomed Pharmacother 174:116500","journal-title":"Biomed Pharmacother"},{"key":"4622_CR18","doi-asserted-by":"publisher","first-page":"156476","DOI":"10.1016\/j.phymed.2025.156476","volume":"139","author":"J Weng","year":"2025","unstructured":"Weng J et al (2025) Yinaoxin granule alleviates cerebral ischemia-reperfusion injury by ferroptosis inhibition through Nrf2 pathway activation. Phytomedicine 139:156476","journal-title":"Phytomedicine"},{"key":"4622_CR19","doi-asserted-by":"publisher","first-page":"1428455","DOI":"10.3389\/fphar.2024.1428455","volume":"15","author":"Z Fu","year":"2024","unstructured":"Fu Z et al (2024) Brozopine ameliorates cognitive impairment via upregulating Nrf2, antioxidation and anti-inflammation activities. Front Pharmacol 15:1428455","journal-title":"Front Pharmacol"},{"issue":"1","key":"4622_CR20","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41419-025-07453-y","volume":"16","author":"D Wen","year":"2025","unstructured":"Wen D et al (2025) NF-\u03baB-mediated EAAT3 upregulation in antioxidant defense and ferroptosis sensitivity in lung cancer. Cell Death Dis 16(1):124","journal-title":"Cell Death Dis"},{"issue":"5","key":"4622_CR21","doi-asserted-by":"publisher","first-page":"115701","DOI":"10.1016\/j.celrep.2025.115701","volume":"44","author":"Z Wang","year":"2025","unstructured":"Wang Z et al (2025) NANS suppresses NF-\u03baB signaling to promote ferroptosis by perturbing iron homeostasis. Cell Rep 44(5):115701","journal-title":"Cell Rep"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-025-04622-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-025-04622-5","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-025-04622-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:11:57Z","timestamp":1772619117000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-025-04622-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,29]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["4622"],"URL":"https:\/\/doi.org\/10.1007\/s11064-025-04622-5","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,29]]},"assertion":[{"value":"7 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2025","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2025","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"Approval for the study was obtained from the relevant ethics committee.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent to Participate"}}],"article-number":"6"}}