{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:23:48Z","timestamp":1790047428968,"version":"4.0.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T00:00:00Z","timestamp":1769212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Nos. 82371204"],"award-info":[{"award-number":["Nos. 82371204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Nos. 82171194"],"award-info":[{"award-number":["Nos. 82171194"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s11064-026-04665-2","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T03:13:25Z","timestamp":1769224405000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Plasma-Derived Exosomal hsa-miR-3677-3p Induces Ferroptosis in Neurons by Targeting ABCB8 in Perioperative Neurocognitive Disorders After Prostate Surgery"],"prefix":"10.1007","volume":"51","author":[{"given":"Yiyan","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohuan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,24]]},"reference":[{"issue":"5","key":"4665_CR1","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/j.bja.2017.11.087","volume":"121","author":"L Evered","year":"2018","unstructured":"Evered L, Silbert B, Knopman DS, Scott DA, DeKosky ST, Rasmussen LS et al (2018) Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018. Br J Anaesth 121(5):1005\u20131012. https:\/\/doi.org\/10.1016\/j.bja.2017.11.087","journal-title":"Br J Anaesth"},{"key":"4665_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-024-2797-x","author":"J Liu","year":"2025","unstructured":"Liu J, Li C, Yao J, Zhang L, Zhao X, Lv X et al (2025) Clinical biomarkers of perioperative neurocognitive disorder: initiation and recommendation. Sci China Life Sci. https:\/\/doi.org\/10.1007\/s11427-024-2797-x","journal-title":"Sci China Life Sci"},{"issue":"Suppl 1","key":"4665_CR3","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/anae.15613","volume":"77","author":"L Evered","year":"2022","unstructured":"Evered L, Atkins K, Silbert B, Scott DA (2022) Acute peri-operative neurocognitive disorders: a narrative review. Anaesthesia 77(Suppl 1):34\u201342. https:\/\/doi.org\/10.1111\/anae.15613","journal-title":"Anaesthesia"},{"issue":"1","key":"4665_CR4","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-021-01705-z","volume":"19","author":"U Kahl","year":"2021","unstructured":"Kahl U, Callsen S, Beck S, Pinnschmidt H, von Breunig F, Haese A et al (2021) Health-related quality of life and self-reported cognitive function in patients with delayed neurocognitive recovery after radical prostatectomy: a prospective follow-up study. Health Qual Life Outcomes 19(1):64. https:\/\/doi.org\/10.1186\/s12955-021-01705-z","journal-title":"Health Qual Life Outcomes"},{"issue":"2","key":"4665_CR5","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s00198-019-05172-7","volume":"31","author":"J Bai","year":"2020","unstructured":"Bai J, Liang Y, Zhang P, Liang X, He J, Wang J et al (2020) Association between postoperative delirium and mortality in elderly patients undergoing hip fractures surgery: a meta-analysis. Osteoporos Int 31(2):317\u2013326. https:\/\/doi.org\/10.1007\/s00198-019-05172-7","journal-title":"Osteoporos Int"},{"issue":"9","key":"4665_CR6","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1007\/s00011-023-01792-2","volume":"72","author":"S Jia","year":"2023","unstructured":"Jia S, Yang H, Huang F, Fan W (2023) Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders. Inflamm Res 72(9):1895\u20131907. https:\/\/doi.org\/10.1007\/s00011-023-01792-2","journal-title":"Inflamm Res"},{"issue":"1","key":"4665_CR7","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01689-6","volume":"11","author":"C Pan","year":"2023","unstructured":"Pan C, Zhang H, Zhang L, Chen L, Xu L, Xu N et al (2023) Surgery-induced gut microbial dysbiosis promotes cognitive impairment via regulation of intestinal function and the metabolite palmitic amide. Microbiome 11(1):248. https:\/\/doi.org\/10.1186\/s40168-023-01689-6","journal-title":"Microbiome"},{"issue":"10","key":"4665_CR8","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70093","volume":"30","author":"Y Niu","year":"2024","unstructured":"Niu Y, Liao G, Miao Z, Xu J, Cheng Y, Wang F et al (2024) Role of Hippocampal glutamatergic synaptic alterations in sevoflurane-induced cognitive dysfunction in aged mice. CNS Neurosci Ther 30(10):e70093. https:\/\/doi.org\/10.1111\/cns.70093","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"4665_CR9","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s12967-022-03493-6","volume":"20","author":"Y Fan","year":"2022","unstructured":"Fan Y, Chen Z, Zhang M (2022) Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases. J Transl Med 20(1):291. https:\/\/doi.org\/10.1186\/s12967-022-03493-6","journal-title":"J Transl Med"},{"key":"4665_CR10","doi-asserted-by":"publisher","DOI":"10.3390\/ijms251810068","author":"M Malaguarnera","year":"2024","unstructured":"Malaguarnera M, Cabrera-Pastor A (2024) Emerging role of extracellular vesicles as biomarkers in neurodegenerative diseases and their clinical and therapeutic potential in central nervous system pathologies. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms251810068","journal-title":"Int J Mol Sci"},{"key":"4665_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2022.121949","volume":"293","author":"FU Rehman","year":"2023","unstructured":"Rehman FU, Liu Y, Zheng M, Shi B (2023) Exosomes based strategies for brain drug delivery. Biomaterials 293:121949. https:\/\/doi.org\/10.1016\/j.biomaterials.2022.121949","journal-title":"Biomaterials"},{"issue":"3","key":"4665_CR12","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s44254-025-00112-7","volume":"3","author":"M Li","year":"2025","unstructured":"Li M, Zhou F, Tian Y (2025) The role of microRNAs in anesthesia and pain: insights from the 2024 Nobel Prize in Physiology or Medicine. Anesthesiol Perioper Sci 3(3):31. https:\/\/doi.org\/10.1007\/s44254-025-00112-7","journal-title":"Anesthesiol Perioper Sci"},{"issue":"5","key":"4665_CR13","doi-asserted-by":"publisher","first-page":"2111","DOI":"10.1007\/s11010-021-04053-0","volume":"476","author":"Y Yu","year":"2021","unstructured":"Yu Y, Hou K, Ji T, Wang X, Liu Y, Zheng Y et al (2021) The role of exosomal microRNAs in central nervous system diseases. Mol Cell Biochem 476(5):2111\u20132124. https:\/\/doi.org\/10.1007\/s11010-021-04053-0","journal-title":"Mol Cell Biochem"},{"issue":"3","key":"4665_CR14","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1001\/jamaneurol.2016.5197","volume":"74","author":"K Regev","year":"2017","unstructured":"Regev K, Healy BC, Khalid F, Paul A, Chu R, Tauhid S et al (2017) Association between serum microRNAs and magnetic resonance imaging measures of multiple sclerosis severity. JAMA Neurol 74(3):275\u2013285. https:\/\/doi.org\/10.1001\/jamaneurol.2016.5197","journal-title":"JAMA Neurol"},{"key":"4665_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175956","volume":"956","author":"S Xia","year":"2023","unstructured":"Xia S, Xu C, Liu F, Chen G (2023) Development of microRNA-based therapeutics for central nervous system diseases. Eur J Pharmacol 956:175956. https:\/\/doi.org\/10.1016\/j.ejphar.2023.175956","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"4665_CR16","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s12974-020-01745-0","volume":"17","author":"N Lai","year":"2020","unstructured":"Lai N, Wu D, Liang T, Pan P, Yuan G, Li X et al (2020) Systemic exosomal miR-193b-3p delivery attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage in mice. J Neuroinflammation 17(1):74. https:\/\/doi.org\/10.1186\/s12974-020-01745-0","journal-title":"J Neuroinflammation"},{"key":"4665_CR17","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.trsl.2024.01.007","volume":"268","author":"J Li","year":"2024","unstructured":"Li J, Xu H, Zhang K, Liu Y, Zeng C, Fu Y et al (2024) Astrocyte-derived exosomes-transported miRNA-26a-5p ameliorates sevoflurane-induced cognitive dysfunction in aged mice. Transl Res 268:79\u201396. https:\/\/doi.org\/10.1016\/j.trsl.2024.01.007","journal-title":"Transl Res"},{"issue":"12","key":"4665_CR18","doi-asserted-by":"publisher","first-page":"3583","DOI":"10.1007\/s11064-022-03785-9","volume":"47","author":"QM Huang","year":"2022","unstructured":"Huang QM, Zhou YY, He HF, Lin S, Chen XR (2022) Research progress on exosomes and MicroRNAs in the microenvironment of postoperative neurocognitive disorders. Neurochem Res 47(12):3583\u20133597. https:\/\/doi.org\/10.1007\/s11064-022-03785-9","journal-title":"Neurochem Res"},{"issue":"1","key":"4665_CR19","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41593-022-01221-3","volume":"26","author":"SK Ryan","year":"2023","unstructured":"Ryan SK, Zelic M, Han Y, Teeple E, Chen L, Sadeghi M et al (2023) Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration. Nat Neurosci 26(1):12\u201326. https:\/\/doi.org\/10.1038\/s41593-022-01221-3","journal-title":"Nat Neurosci"},{"issue":"1","key":"4665_CR20","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02560-y","volume":"22","author":"Y Wang","year":"2024","unstructured":"Wang Y, Liu Z, Li L, Zhang Z, Zhang K, Chu M et al (2024) Anti-ferroptosis exosomes engineered for targeting M2 microglia to improve neurological function in ischemic stroke. J Nanobiotechnology 22(1):291. https:\/\/doi.org\/10.1186\/s12951-024-02560-y","journal-title":"J Nanobiotechnology"},{"issue":"1","key":"4665_CR21","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-025-03502-y","volume":"23","author":"L Zeng","year":"2025","unstructured":"Zeng L, Hu P, Wang X, Ding X, Wang Q, Luo L et al (2025) Sirtuin-3 activation by honokiol attenuated anesthesia\/surgery-induced cognitive impairment and neuronal ferroptosis via inhibiting mitochondrial GPX4 acetylation. J Nanobiotechnology 23(1):414. https:\/\/doi.org\/10.1186\/s12951-025-03502-y","journal-title":"J Nanobiotechnology"},{"issue":"10","key":"4665_CR22","doi-asserted-by":"publisher","DOI":"10.1111\/cns.70066","volume":"30","author":"S Wang","year":"2024","unstructured":"Wang S, Wu Z, Bu X, Peng X, Zhou Q, Song W et al (2024) MEF2C alleviates postoperative cognitive dysfunction by repressing ferroptosis. CNS Neurosci Ther 30(10):e70066. https:\/\/doi.org\/10.1111\/cns.70066","journal-title":"CNS Neurosci Ther"},{"key":"4665_CR23","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.2147\/jir.S503784","volume":"18","author":"L Lin","year":"2025","unstructured":"Lin L, Ling X, Chen T, Zhou Q, Huang J, Huang L et al (2025) Inhibition of hippocampal neuronal ferroptosis by liproxstatin-1 improves learning and memory function in aged mice with perioperative neurocognitive dysfunction. J Inflamm Res 18:2991\u20133007. https:\/\/doi.org\/10.2147\/jir.S503784","journal-title":"J Inflamm Res"},{"key":"4665_CR24","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.isci.2018.12.005","volume":"11","author":"T Issitt","year":"2019","unstructured":"Issitt T, Bosseboeuf E, De Winter N, Dufton N, Gestri G, Senatore V et al (2019) Neuropilin-1 controls endothelial homeostasis by regulating mitochondrial function and iron-dependent oxidative stress. iScience 11:205\u2013223. https:\/\/doi.org\/10.1016\/j.isci.2018.12.005","journal-title":"iScience"},{"issue":"2","key":"4665_CR25","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1172\/jci72931","volume":"124","author":"Y Ichikawa","year":"2014","unstructured":"Ichikawa Y, Ghanefar M, Bayeva M, Wu R, Khechaduri A, Naga Prasad SV et al (2014) Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation. J Clin Invest 124(2):617\u201330. https:\/\/doi.org\/10.1172\/jci72931","journal-title":"J Clin Invest"},{"key":"4665_CR26","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.817951","volume":"13","author":"AV Menon","year":"2022","unstructured":"Menon AV, Kim J (2022) Iron promotes cardiac doxorubicin retention and toxicity through downregulation of the mitochondrial exporter ABCB8. Front Pharmacol 13:817951. https:\/\/doi.org\/10.3389\/fphar.2022.817951","journal-title":"Front Pharmacol"},{"key":"4665_CR27","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9280170","volume":"2017","author":"DG Weber","year":"2017","unstructured":"Weber DG, Gawrych K, Casjens S, Brik A, Lehnert M, Taeger D et al (2017) Circulating miR-132-3p as a candidate diagnostic biomarker for malignant mesothelioma. Dis Markers 2017:9280170. https:\/\/doi.org\/10.1155\/2017\/9280170","journal-title":"Dis Markers"},{"key":"4665_CR28","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-020-00194-4","volume":"8","author":"DG Weber","year":"2020","unstructured":"Weber DG, Casjens S, Brik A, Raiko I, Lehnert M, Taeger D et al (2020) Circulating long non-coding RNA GAS5 (growth arrest-specific transcript 5) as a complement marker for the detection of malignant mesothelioma using liquid biopsies. Biomark Res 8:15. https:\/\/doi.org\/10.1186\/s40364-020-00194-4","journal-title":"Biomark Res"},{"issue":"1","key":"4665_CR29","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1074\/mcp.M112.026500","volume":"13","author":"NW Bateman","year":"2014","unstructured":"Bateman NW, Goulding SP, Shulman NJ, Gadok AK, Szumlinski KK, MacCoss MJ et al (2014) Maximizing peptide identification events in proteomic workflows using data-dependent acquisition (DDA). Mol Cell Proteomics 13(1):329\u201338. https:\/\/doi.org\/10.1074\/mcp.M112.026500","journal-title":"Mol Cell Proteomics"},{"key":"4665_CR30","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2013.00094","volume":"4","author":"MB Kirschner","year":"2013","unstructured":"Kirschner MB, Edelman JJ, Kao SC, Vallely MP, van Zandwijk N, Reid G (2013) The impact of hemolysis on cell-free microRNA biomarkers. Front Genet 4:94. https:\/\/doi.org\/10.3389\/fgene.2013.00094","journal-title":"Front Genet"},{"key":"4665_CR31","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25031853","author":"L Chico-Sordo","year":"2024","unstructured":"Chico-Sordo L, Ruiz-Mart\u00ednez T, Toribio M, Gonz\u00e1lez-Mart\u00edn R, Spagnolo E, Dom\u00ednguez F et al (2024) Identification of miR-30c-5p microrna in serum as a candidate biomarker to diagnose endometriosis. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25031853","journal-title":"Int J Mol Sci"},{"key":"4665_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/nu14214599","author":"Y Li","year":"2022","unstructured":"Li Y, Sun M, Cao F, Chen Y, Zhang L, Li H et al (2022) The ferroptosis inhibitor liproxstatin-1 ameliorates LPS-induced cognitive impairment in mice. Nutrients. https:\/\/doi.org\/10.3390\/nu14214599","journal-title":"Nutrients"},{"issue":"2","key":"4665_CR33","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1093\/toxsci\/kfad071","volume":"195","author":"Y Xu","year":"2023","unstructured":"Xu Y, Wang X, Xu Z, Sun F, Tian Y (2023) Tbx2 knockdown alleviated sevoflurane-induced cognitive disorder and neuron damages in aged rats via suppressing oxidative stress and ferroptosis. Toxicol Sci 195(2):257\u2013269. https:\/\/doi.org\/10.1093\/toxsci\/kfad071","journal-title":"Toxicol Sci"},{"key":"4665_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.117832","volume":"183","author":"H Zheng","year":"2025","unstructured":"Zheng H, Ou J, Han H, Lu Q, Shen Y (2025) SS-31@Fer-1 alleviates ferroptosis in hypoxia\/reoxygenation cardiomyocytes via mitochondrial targeting. Biomed Pharmacother 183:117832. https:\/\/doi.org\/10.1016\/j.biopha.2025.117832","journal-title":"Biomed Pharmacother"},{"key":"4665_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101670","volume":"36","author":"DC Fuhrmann","year":"2020","unstructured":"Fuhrmann DC, Mondorf A, Beifu\u00df J, Jung M, Br\u00fcne B (2020) Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis. Redox Biol 36:101670. https:\/\/doi.org\/10.1016\/j.redox.2020.101670","journal-title":"Redox Biol"},{"key":"4665_CR36","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061505","author":"AM Battaglia","year":"2020","unstructured":"Battaglia AM, Chirillo R, Aversa I, Sacco A, Costanzo F, Biamonte F (2020) Ferroptosis and cancer: mitochondria meet the \u201cIron Maiden\u201d cell death. Cells. https:\/\/doi.org\/10.3390\/cells9061505","journal-title":"Cells"},{"issue":"12","key":"4665_CR37","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1021\/acschemneuro.7b00287","volume":"8","author":"WJ Geldenhuys","year":"2017","unstructured":"Geldenhuys WJ, Benkovic SA, Lin L, Yonutas HM, Crish SD, Sullivan PG et al (2017) MitoNEET (CISD1) knockout mice show signs of striatal mitochondrial dysfunction and a Parkinson\u2019s disease phenotype. ACS Chem Neurosci 8(12):2759\u20132765. https:\/\/doi.org\/10.1021\/acschemneuro.7b00287","journal-title":"ACS Chem Neurosci"},{"issue":"2","key":"4665_CR38","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s12031-018-1155-6","volume":"66","author":"JR Wu","year":"2018","unstructured":"Wu JR, Tuo QZ, Lei P (2018) Ferroptosis, a recent defined form of critical cell death in neurological disorders. J Mol Neurosci 66(2):197\u2013206. https:\/\/doi.org\/10.1007\/s12031-018-1155-6","journal-title":"J Mol Neurosci"},{"key":"4665_CR39","doi-asserted-by":"publisher","first-page":"8135","DOI":"10.2147\/jir.S482051","volume":"17","author":"X Wu","year":"2024","unstructured":"Wu X, Ding S, Wang G, Zhang W, He K (2024) ZLN005 reduces neuroinflammation and improves mitochondrial function in mice with perioperative neurocognitive disorders. J Inflamm Res 17:8135\u20138146. https:\/\/doi.org\/10.2147\/jir.S482051","journal-title":"J Inflamm Res"},{"issue":"3","key":"4665_CR40","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14433","volume":"30","author":"J Huang","year":"2024","unstructured":"Huang J, Zhu Y, Liu Y, Zhang R, Zhang Z, Liu J et al (2024) The cold-inducible RNA-binding protein-Thioredoxin 1 pathway ameliorates mitochondrial dysfunction and mitochondrial dynamin-related protein 1 level in the hippocampus of aged mice with perioperative neurocognitive dysfunction. CNS Neurosci Ther 30(3):e14433. https:\/\/doi.org\/10.1111\/cns.14433","journal-title":"CNS Neurosci Ther"},{"issue":"1","key":"4665_CR41","doi-asserted-by":"publisher","first-page":"2411012","DOI":"10.1080\/07853890.2024.2411012","volume":"56","author":"F Ye","year":"2024","unstructured":"Ye F, Wei C, Wu A (2024) The potential mechanism of mitochondrial homeostasis in postoperative neurocognitive disorders: an in-depth review. Ann Med 56(1):2411012. https:\/\/doi.org\/10.1080\/07853890.2024.2411012","journal-title":"Ann Med"},{"issue":"1","key":"4665_CR42","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-024-03285-3","volume":"21","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Yang W, Wang L, Zhu C, Cui S, Wang T et al (2024) Unraveling the role and mechanism of mitochondria in postoperative cognitive dysfunction: a narrative review. J Neuroinflammation 21(1):293. https:\/\/doi.org\/10.1186\/s12974-024-03285-3","journal-title":"J Neuroinflammation"},{"issue":"1","key":"4665_CR43","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-023-05064-4","volume":"81","author":"A Sanz-Alc\u00e1zar","year":"2023","unstructured":"Sanz-Alc\u00e1zar A, Britti E, Delaspre F, Medina-Carbonero M, Pazos-Gil M, Tamarit J et al (2023) Mitochondrial impairment, decreased sirtuin activity and protein acetylation in dorsal root ganglia in Friedreich Ataxia models. Cell Mol Life Sci 81(1):12. https:\/\/doi.org\/10.1007\/s00018-023-05064-4","journal-title":"Cell Mol Life Sci"},{"key":"4665_CR44","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.neuro.2021.11.003","volume":"88","author":"R Cheng","year":"2022","unstructured":"Cheng R, Dhorajia VV, Kim J, Kim Y (2022) Mitochondrial iron metabolism and neurodegenerative diseases. Neurotoxicology 88:88\u2013101. https:\/\/doi.org\/10.1016\/j.neuro.2021.11.003","journal-title":"Neurotoxicology"},{"key":"4665_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101483","volume":"32","author":"J Du","year":"2020","unstructured":"Du J, Zhou Y, Li Y, Xia J, Chen Y, Chen S et al (2020) Identification of Frataxin as a regulator of ferroptosis. Redox Biol 32:101483. https:\/\/doi.org\/10.1016\/j.redox.2020.101483","journal-title":"Redox Biol"},{"issue":"3","key":"4665_CR46","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s10565-021-09624-x","volume":"38","author":"B Niu","year":"2022","unstructured":"Niu B, Lei X, Xu Q, Ju Y, Xu D, Mao L et al (2022) Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury. Cell Biol Toxicol 38(3):505\u2013530. https:\/\/doi.org\/10.1007\/s10565-021-09624-x","journal-title":"Cell Biol Toxicol"},{"key":"4665_CR47","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114625","volume":"155","author":"R You","year":"2025","unstructured":"You R, Sun B, Luo J, Shao N, Si W (2025) Exploring the role of Mitoferrin-1 in ferroptosis and mitochondrial damage in acute ischemic stroke. Int Immunopharmacol 155:114625. https:\/\/doi.org\/10.1016\/j.intimp.2025.114625","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"4665_CR48","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s12011-021-02627-z","volume":"200","author":"X Wang","year":"2022","unstructured":"Wang X, Ma H, Sun J, Zheng T, Zhao P, Li H et al (2022) Mitochondrial ferritin deficiency promotes osteoblastic ferroptosis via mitophagy in type 2 diabetic osteoporosis. Biol Trace Elem Res 200(1):298\u2013307. https:\/\/doi.org\/10.1007\/s12011-021-02627-z","journal-title":"Biol Trace Elem Res"},{"key":"4665_CR49","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2014.00019","volume":"5","author":"G Gao","year":"2014","unstructured":"Gao G, Chang YZ (2014) Mitochondrial ferritin in the regulation of brain iron homeostasis and neurodegenerative diseases. Front Pharmacol 5:19. https:\/\/doi.org\/10.3389\/fphar.2014.00019","journal-title":"Front Pharmacol"},{"issue":"1","key":"4665_CR50","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-024-00588-1","volume":"15","author":"J Llera-Oyola","year":"2024","unstructured":"Llera-Oyola J, Carceller H, Andreu Z, Hidalgo MR, Soler-S\u00e1ez I, Gordillo F et al (2024) The role of microRNAs in understanding sex-based differences in Alzheimer\u2019s disease. Biol Sex Differ 15(1):13. https:\/\/doi.org\/10.1186\/s13293-024-00588-1","journal-title":"Biol Sex Differ"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-026-04665-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-026-04665-2","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-026-04665-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:11:20Z","timestamp":1772619080000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-026-04665-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,24]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["4665"],"URL":"https:\/\/doi.org\/10.1007\/s11064-026-04665-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-6945640\/v1","asserted-by":"object"}]},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,24]]},"assertion":[{"value":"21 June 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 December 2025","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"The clinical trials of this study have been registered with the Chinese Clinical Trial Registry (ChiCTR) with the unique identifier ChiCTR2100043475 (\n                      \n                      ).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}],"article-number":"59"}}