{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:42:34Z","timestamp":1788997354469,"version":"build-2803163510"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["DST\/INSPIRE Fellowship\/2023\/IF230052"],"award-info":[{"award-number":["DST\/INSPIRE Fellowship\/2023\/IF230052"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["3\/1\/2\/127\/Neuro\/2019-NCD-1"],"award-info":[{"award-number":["3\/1\/2\/127\/Neuro\/2019-NCD-1"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["No. 5\/4-5\/3\/38\/Neuro\/2022\/NCD-I"],"award-info":[{"award-number":["No. 5\/4-5\/3\/38\/Neuro\/2022\/NCD-I"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1007\/s11064-026-04691-0","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T08:29:23Z","timestamp":1770452963000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Decanoic Acid Treatment Alleviates Non-cell Autonomous Transfer of HD Pathology by Secretome of Mutant Huntingtin Expressing Cells"],"prefix":"10.1007","volume":"51","author":[{"given":"Ragi","family":"Mehta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajubhai","family":"Dabhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushmita","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3572-1441","authenticated-orcid":false,"given":"Ravi","family":"Vijayvargia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,7]]},"reference":[{"key":"4691_CR1","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"ME MacDonald","year":"1993","unstructured":"MacDonald ME, Ambrose CM, Duyao MP et al (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on huntington\u2019s disease chromosomes. Cell 72:971\u2013983. https:\/\/doi.org\/10.1016\/0092-8674(93)90585-E","journal-title":"Cell"},{"key":"4691_CR2","doi-asserted-by":"publisher","first-page":"8808","DOI":"10.1074\/jbc.M109.075028","volume":"285","author":"C Landles","year":"2010","unstructured":"Landles C, Sathasivam K, Weiss A et al (2010) Proteolysis of mutant Huntingtin produces an exon 1 fragment that accumulates as an aggregated protein in neuronal nuclei in huntington disease. J Biol Chem 285:8808\u20138823. https:\/\/doi.org\/10.1074\/jbc.M109.075028","journal-title":"J Biol Chem"},{"key":"4691_CR3","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1126\/science.277.5334.1990","volume":"277","author":"M DiFiglia","year":"1997","unstructured":"DiFiglia M, Sapp E, Chase KO et al (1997) Aggregation of Huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Sci (80-) 277:1990\u20131993. https:\/\/doi.org\/10.1126\/science.277.5334.1990","journal-title":"Sci (80-)"},{"key":"4691_CR4","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1093\/hmg\/ddr024","volume":"20","author":"U Shirendeb","year":"2011","unstructured":"Shirendeb U, Reddy AP, Manczak M et al (2011) Abnormal mitochondrial dynamics, mitochondrial loss and mutant Huntingtin oligomers in huntington\u2019s disease: implications for selective neuronal damage. Hum Mol Genet 20:1438\u20131455. https:\/\/doi.org\/10.1093\/hmg\/ddr024","journal-title":"Hum Mol Genet"},{"key":"4691_CR5","doi-asserted-by":"publisher","first-page":"6106","DOI":"10.1128\/mcb.00420-09","volume":"29","author":"X Li","year":"2009","unstructured":"Li X, Standley C, Sapp E et al (2009) Mutant Huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity. Mol Cell Biol 29:6106\u20136116. https:\/\/doi.org\/10.1128\/mcb.00420-09","journal-title":"Mol Cell Biol"},{"key":"4691_CR6","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/j.cell.2005.10.030","volume":"123","author":"W Zhai","year":"2005","unstructured":"Zhai W, Jeong H, Cui L et al (2005) In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets. Cell 123:1241\u20131253. https:\/\/doi.org\/10.1016\/j.cell.2005.10.030","journal-title":"Cell"},{"key":"4691_CR7","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s10863-010-9286-7","volume":"42","author":"YN Jin","year":"2010","unstructured":"Jin YN, Johnson GVW (2010) The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in huntington disease. J Bioenerg Biomembr 42:199\u2013205","journal-title":"J Bioenerg Biomembr"},{"key":"4691_CR8","doi-asserted-by":"publisher","first-page":"3919","DOI":"10.1093\/hmg\/ddq306","volume":"19","author":"J Kim","year":"2010","unstructured":"Kim J, Moody JP, Edgerly CK et al (2010) Mitochondrial loss, dysfunction and altered dynamics in huntington\u2019s disease. Hum Mol Genet 19:3919\u20133935. https:\/\/doi.org\/10.1093\/hmg\/ddq306","journal-title":"Hum Mol Genet"},{"key":"4691_CR9","doi-asserted-by":"publisher","first-page":"6534","DOI":"10.1038\/s41467-024-50877-x","volume":"15","author":"M Galimberti","year":"2024","unstructured":"Galimberti M, Nucera MR, Bocchi VD et al (2024) Huntington \u2019 s disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids. Nat Commun 15:6534. https:\/\/doi.org\/10.1038\/s41467-024-50877-x","journal-title":"Nat Commun"},{"key":"4691_CR10","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1146\/annurev-neuro-072116-031153","volume":"40","author":"M Goedert","year":"2017","unstructured":"Goedert M, Eisenberg DS, Crowther RA (2017) Propagation of Tau aggregates and neurodegeneration. Annu Rev Neurosci 40:189\u2013210. https:\/\/doi.org\/10.1146\/annurev-neuro-072116-031153","journal-title":"Annu Rev Neurosci"},{"key":"4691_CR11","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","volume":"24","author":"H Braak","year":"2003","unstructured":"Braak H, Del Tredici K, R\u00fcb U et al (2003) Staging of brain pathology related to sporadic parkinson\u2019s disease. Neurobiol Aging 24:197\u2013211. https:\/\/doi.org\/10.1016\/S0197-4580(02)00065-9","journal-title":"Neurobiol Aging"},{"key":"4691_CR12","doi-asserted-by":"publisher","first-page":"3620","DOI":"10.1073\/pnas.1312245111","volume":"111","author":"LI Grad","year":"2014","unstructured":"Grad LI, Yerbury JJ, Turner BJ et al (2014) Intercellular propagated misfolding of wild-type Cu\/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms. Proc Natl Acad Sci U S A 111:3620\u20133625. https:\/\/doi.org\/10.1073\/pnas.1312245111","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4691_CR13","doi-asserted-by":"publisher","first-page":"13363","DOI":"10.1073\/pnas.95.23.13363","volume":"95","author":"SB Prusiner","year":"1998","unstructured":"Prusiner SB (1998) Prions. Proc Natl Acad Sci U S A 95:13363\u201313383. https:\/\/doi.org\/10.1073\/pnas.95.23.13363","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4691_CR14","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1002\/ana.24174","volume":"76","author":"F Cicchetti","year":"2014","unstructured":"Cicchetti F, Lacroix S, Cisbani G et al (2014) Mutant Huntingtin is present in neuronal grafts in huntington disease patients. Ann Neurol 76:31\u201342. https:\/\/doi.org\/10.1002\/ana.24174","journal-title":"Ann Neurol"},{"key":"4691_CR15","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1038\/nn.3761","volume":"17","author":"E Pecho-Vrieseling","year":"2014","unstructured":"Pecho-Vrieseling E, Rieker C, Fuchs S et al (2014) Transneuronal propagation of mutant Huntingtin contributes to non-cell autonomous pathology in neurons. Nat Neurosci 17:1064\u20131072. https:\/\/doi.org\/10.1038\/nn.3761","journal-title":"Nat Neurosci"},{"key":"4691_CR16","doi-asserted-by":"publisher","first-page":"E5427","DOI":"10.1073\/pnas.1516217112","volume":"112","author":"DT Babcock","year":"2015","unstructured":"Babcock DT, Ganetzky B (2015) Transcellular spreading of Huntingtin aggregates in the drosophila brain. Proc Natl Acad Sci U S A 112:E5427\u2013E5433. https:\/\/doi.org\/10.1073\/pnas.1516217112","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4691_CR17","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/j.bbadis.2016.12.015","volume":"1863","author":"AHP Jansen","year":"2017","unstructured":"Jansen AHP, Batenburg KL, Pecho-Vrieseling E, Reits EA (2017) Visualization of prion-like transfer in Huntingtons disease models. BBA Mol Basis Dis 1863:793\u2013800. https:\/\/doi.org\/10.1016\/j.bbadis.2016.12.015","journal-title":"BBA Mol Basis Dis"},{"key":"4691_CR18","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s00401-016-1582-9","volume":"132","author":"I Jeon","year":"2016","unstructured":"Jeon I, Cicchetti F, Cisbani G et al (2016) Human-to-mouse prion-like propagation of mutant Huntingtin protein. Acta Neuropathol 132:577\u2013592. https:\/\/doi.org\/10.1007\/s00401-016-1582-9","journal-title":"Acta Neuropathol"},{"key":"4691_CR19","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1038\/mp.2015.81","volume":"20","author":"Z Tan","year":"2015","unstructured":"Tan Z, Dai W, Van Erp TGM et al (2015) Huntington\u2019s disease cerebrospinal fluid seeds aggregation of mutant Huntingtin. Mol Psychiatry 20:1286\u20131293. https:\/\/doi.org\/10.1038\/mp.2015.81","journal-title":"Mol Psychiatry"},{"key":"4691_CR20","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1084\/jem.20080178","volume":"205","author":"M Bj\u00f6rkqvist","year":"2008","unstructured":"Bj\u00f6rkqvist M, Wild EJ, Thiele J et al (2008) A novel pathogenic pathway of immune activation detectable before clinical onset in huntington\u2019s disease. J Exp Med 205:1869\u20131877. https:\/\/doi.org\/10.1084\/jem.20080178","journal-title":"J Exp Med"},{"key":"4691_CR21","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/j.bbadis.2009.10.013","volume":"1802","author":"C Schwab","year":"2010","unstructured":"Schwab C, Klegeris A, Mcgeer PL (2010) Inflammation in transgenic mouse models of neurodegenerative disorders. BBA Mol Basis Dis 1802:889\u2013902. https:\/\/doi.org\/10.1016\/j.bbadis.2009.10.013","journal-title":"BBA Mol Basis Dis"},{"key":"4691_CR22","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/cei.13119","volume":"192","author":"G Ellrichmann","year":"2018","unstructured":"Ellrichmann G, Reick C, Saft C, Linker RA (2018) The role of the immune system in Huntington\u2019s disease. Clin Exp Immunol 192:142\u2013150. https:\/\/doi.org\/10.1111\/cei.13119","journal-title":"Clin Exp Immunol"},{"key":"4691_CR23","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1007\/s13311-020-00891-w","volume":"17","author":"D Dash","year":"2020","unstructured":"Dash D, Mestre TA (2020) Therapeutic update on huntington\u2019s disease: symptomatic treatments and emerging Disease-Modifying therapies. Neurother J Am Soc Exp Neurother 17:1645\u20131659. https:\/\/doi.org\/10.1007\/s13311-020-00891-w","journal-title":"Neurother J Am Soc Exp Neurother"},{"key":"4691_CR24","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/j.1749-6632.2009.04975.x","volume":"1175","author":"J Hu","year":"2009","unstructured":"Hu J, Matsui M, Corey DR (2009) Allele-selective inhibition of mutant huntingtin by peptide nucleic acid (PNA)-peptide conjugates, locked nucleic acid (LNA), and SiRNA. Ann N Y Acad Sci 1175:24\u201331 https:\/\/doi.org\/10.1111\/j.1749-6632.2009.04975.x.Allele-Selective","journal-title":"Ann N Y Acad Sci"},{"key":"4691_CR25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1096\/fj.04-3182fje","volume":"19","author":"J Wang","year":"2005","unstructured":"Wang J, Ho L, Qin W et al (2005) Caloric restriction attenuates \u03b2-amyloid neuropathology in a mouse model of Alzheimer\u2019s disease. FASEB J 19:1\u201318. https:\/\/doi.org\/10.1096\/fj.04-3182fje","journal-title":"FASEB J"},{"key":"4691_CR26","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/brain\/awv325","volume":"139","author":"P Chang","year":"2016","unstructured":"Chang P, Augustin K, Boddum K et al (2016) Seizure control by decanoic acid through direct AMPA receptor Inhibition. Brain 139:431\u2013443. https:\/\/doi.org\/10.1093\/brain\/awv325","journal-title":"Brain"},{"key":"4691_CR27","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1186\/s13041-021-00842-2","volume":"14","author":"JV Andersen","year":"2021","unstructured":"Andersen JV, Westi EW, Jakobsen E et al (2021) Astrocyte metabolism of the medium-chain fatty acids octanoic acid and decanoic acid promotes GABA synthesis in neurons via elevated glutamine supply. Mol Brain 14:132. https:\/\/doi.org\/10.1186\/s13041-021-00842-2","journal-title":"Mol Brain"},{"key":"4691_CR28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2022.1004568","volume":"13","author":"T Sanguanphun","year":"2022","unstructured":"Sanguanphun T, Sornkaew N, Malaiwong N et al (2022) Neuroprotective effects of a medium chain fatty acid, decanoic acid, isolated from H. leucospilota against parkinsonism in C. elegans PD model. Front Pharmacol 13:1\u201317. https:\/\/doi.org\/10.3389\/fphar.2022.1004568","journal-title":"Front Pharmacol"},{"key":"4691_CR29","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.3390\/cells10112946","volume":"10","author":"EC Warren","year":"2021","unstructured":"Warren EC, Kram P, Lloyd-Jones K, Williams RSB (2021) Decanoic acid stimulates autophagy in D. discoideum. Cells 10:2946","journal-title":"Cells"},{"key":"4691_CR30","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1111\/j.1742-4658.2007.05647.x","volume":"274","author":"A-S Johansson","year":"2007","unstructured":"Johansson A-S, Garlind A, Berglind-Dehlin F, Karlsson G, Edwards K, P\u00e4r Gellerfors, Ekholm-Pettersson F, Palmblad J (2007) Docosahexaenoic acid stabilizes soluble amyloid-beta protofibrils and sustains amyloid-beta-induced neurotoxicity in vitro. FASEB J 274:990\u20131000 https:\/\/doi.org\/10.1111\/j.1742-4658.2007.05647.x","journal-title":"FASEB J"},{"key":"4691_CR31","doi-asserted-by":"publisher","first-page":"741","DOI":"10.56042\/ijbb.v60i9.4047","volume":"60","author":"R Dabhi","year":"2023","unstructured":"Dabhi R, Mehta R, Paneri J et al (2023) Determination of neuroprotective effects of medium chain fatty acids and their derivatives on mutant Huntingtin aggregates, oxidative stress and ATP levels in HD150Q cell line model of huntington\u2019s disease. Indian J Biochem Biophys 60:741\u2013749. https:\/\/doi.org\/10.56042\/ijbb.v60i9.4047","journal-title":"Indian J Biochem Biophys"},{"key":"4691_CR32","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1093\/hmg\/ddaf052","volume":"34","author":"R Dabhi","year":"2025","unstructured":"Dabhi R, Mehta R, Kakadiya D, Vijayvargia R (2025) Kinetin mediated mutant Huntingtin phosphorylation restores multiple dysregulated pathways in a cell line model of huntington\u2019s disease. Hum Mol Genet 34:1097\u20131107. https:\/\/doi.org\/10.1093\/hmg\/ddaf052","journal-title":"Hum Mol Genet"},{"key":"4691_CR33","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.1097\/00001756-199908200-00001","volume":"10","author":"GH Wang","year":"1999","unstructured":"Wang GH, Mitsui K, Kotliarova S et al (1999) Caspase activation during apoptotic cell death induced by expanded polyglutamine in N2a cells. NeuroReport 10:2435\u20132438. https:\/\/doi.org\/10.1097\/00001756-199908200-00001","journal-title":"NeuroReport"},{"key":"4691_CR34","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1093\/hmg\/9.19.2799","volume":"9","author":"F Trettel","year":"2000","unstructured":"Trettel F, Rigamonti D, Hilditch-Maguire P et al (2000) Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells. Hum Mol Genet 9:2799\u20132809. https:\/\/doi.org\/10.1093\/hmg\/9.19.2799","journal-title":"Hum Mol Genet"},{"key":"4691_CR35","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.bbrc.2006.02.104","volume":"342","author":"P Dikshit","year":"2006","unstructured":"Dikshit P, Goswami A, Mishra A et al (2006) Curcumin enhances the polyglutamine-expanded truncated N-terminal huntingtin-induced cell death by promoting proteasomal malfunction. Biochem Biophys Res Commun 342:1323\u20131328. https:\/\/doi.org\/10.1016\/j.bbrc.2006.02.104","journal-title":"Biochem Biophys Res Commun"},{"key":"4691_CR36","doi-asserted-by":"publisher","first-page":"741","DOI":"10.56042\/ijbb.v60i9.4047","volume":"60","author":"R Dabhi","year":"2023","unstructured":"Dabhi R, Mehta R, Paneri J, Kakadiya D, Shah A et al (2023) Determination of neuroprotective effects of medium chain fatty acids and their derivatives on mutant Huntingtin aggregates, oxidative stress and ATP levels in HD150Q cell line model of huntington\u2019s disease. Indian J Biochem Biophys 60:741\u2013749 https:\/\/doi.org\/10.56042\/ijbb.v60i9.4047","journal-title":"Indian J Biochem Biophys"},{"key":"4691_CR37","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-\u2206\u2206CT method. Methods 25:402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"key":"4691_CR38","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55\u201363. https:\/\/doi.org\/10.1016\/0022-1759(83)90303-4","journal-title":"J Immunol Methods"},{"key":"4691_CR39","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1002\/mds.20373","volume":"20","author":"C Saft","year":"2005","unstructured":"Saft C, Zange J, Andrich J et al (2005) Mitochondrial impairment in patients and asymptomatic mutation carriers of huntington\u2019s disease. Mov Disord 20:674\u2013679. https:\/\/doi.org\/10.1002\/mds.20373","journal-title":"Mov Disord"},{"key":"4691_CR40","doi-asserted-by":"publisher","first-page":"102219","DOI":"10.1016\/j.jbc.2022.102219","volume":"298","author":"E Ahat","year":"2022","unstructured":"Ahat E, Bui S, Zhang J et al (2022) GRASP55 regulates the unconventional secretion and aggregation of mutant Huntingtin. J Biol Chem 298:102219. https:\/\/doi.org\/10.1016\/j.jbc.2022.102219","journal-title":"J Biol Chem"},{"key":"4691_CR41","doi-asserted-by":"publisher","first-page":"e23318","DOI":"10.4161\/cib.23318","volume":"6","author":"CR Desmond","year":"2013","unstructured":"Desmond CR, Maiuri T, Truant R (2013) A multifunctional, multi-pathway intracellular localization signal in Huntingtin. Commun Integr Biol 6:e23318 https:\/\/doi.org\/10.4161\/cib.23318","journal-title":"Commun Integr Biol"},{"key":"4691_CR42","doi-asserted-by":"publisher","first-page":"2905","DOI":"10.1093\/hmg\/11.23.2905","volume":"11","author":"HYE Chan","year":"2002","unstructured":"Chan HYE, Warrick JM, Andriola I et al (2002) Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells. Hum Mol Genet 11:2905\u20132917. https:\/\/doi.org\/10.1093\/hmg\/11.23.2905","journal-title":"Hum Mol Genet"},{"key":"4691_CR43","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1038\/ncb1830","volume":"11","author":"PH Ren","year":"2009","unstructured":"Ren PH, Lauckner JE, Kachirskaia I et al (2009) Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates. Nat Cell Biol 11:219\u2013225. https:\/\/doi.org\/10.1038\/ncb1830","journal-title":"Nat Cell Biol"},{"key":"4691_CR44","doi-asserted-by":"publisher","first-page":"015005","DOI":"10.1088\/2050-6120\/ab854d","volume":"9","author":"S Sameni","year":"2021","unstructured":"Sameni S, Zhang R, Digman MA (2021) The phasor FLIM method reveals a link between a change in energy metabolism and mHtt protein spread in healthy mammalian cells when co- cultured with huntington diseased cells the phasor FLIM method reveals a link between a change in energy metabolism and. Methods Appl Fluoresc 9:015005. https:\/\/doi.org\/10.1088\/2050-6120\/ab854d","journal-title":"Methods Appl Fluoresc"},{"issue":"1","key":"4691_CR45","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/1750-1326-6-32","volume":"6","author":"E Taherzadeh-fard","year":"2011","unstructured":"Taherzadeh-fard E, Saft C, Akkad DA et al (2011) PGC-1alpha downstream transcription factors NRF-1 and TFAM are genetic modifiers of Huntington disease. Mol Neurodegener 6(1):32","journal-title":"Mol Neurodegener"},{"key":"4691_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1750-1326-8-45","volume":"8","author":"RA Quintanilla","year":"2013","unstructured":"Quintanilla RA, Jin YN, Von Bernhardi R, Johnson GV (2013) Mitochondrial permeability transition pore induces mitochondria injury in huntington disease. Mol Neurodegener 8:1\u201319. https:\/\/doi.org\/10.1186\/1750-1326-8-45","journal-title":"Mol Neurodegener"},{"key":"4691_CR47","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3389\/fmolb.2019.00020","volume":"6","author":"T Shacham","year":"2019","unstructured":"Shacham T, Sharma N, Lederkremer GZ (2019) Protein misfolding and ER stress in huntington\u2019s disease. Front Mol Biosci 6:20 https:\/\/doi.org\/10.3389\/fmolb.2019.00020","journal-title":"Front Mol Biosci"},{"key":"4691_CR48","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00401-015-1462-8","volume":"130","author":"W Scheper","year":"2015","unstructured":"Scheper W, Hoozemans JJM (2015) The unfolded protein response in neurodegenerative diseases: a neuropathological perspective. Acta Neuropathol 130:315\u2013331. https:\/\/doi.org\/10.1007\/s00401-015-1462-8","journal-title":"Acta Neuropathol"},{"key":"4691_CR49","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.1073\/pnas.0409402102","volume":"102","author":"TS Tang","year":"2005","unstructured":"Tang TS, Slow E, Lupu V et al (2005) Disturbed Ca2+\u2009signalling and apoptosis of medium spiny neurons in Huntington\u2019s disease. Proc Natl Acad Sci U S A 102:2602\u20132607. https:\/\/doi.org\/10.1073\/pnas.0409402102","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"4691_CR50","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11064-024-04293-8","volume":"50","author":"OB Rivera-Maya","year":"2025","unstructured":"Rivera-Maya OB, Ortiz-Robles CD, Palacios-Valladares JR, Calder\u00f3n-Aranda ES (2025) Dopamine D1-Like receptor stimulation induces CREB, Arc, and BDNF dynamic changes in differentiated SH-SY5Y cells. Neurochem Res 50(1):35 https:\/\/doi.org\/10.1007\/s11064-024-04293-8","journal-title":"Neurochem Res"},{"key":"4691_CR51","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1111\/jnc.12646","volume":"129","author":"SD Hughes","year":"2014","unstructured":"Hughes SD, Kanabus M, Anderson G et al (2014) The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells. J Neurochem 129:426\u2013433. https:\/\/doi.org\/10.1111\/jnc.12646","journal-title":"J Neurochem"},{"key":"4691_CR52","doi-asserted-by":"publisher","first-page":"23617","DOI":"10.1073\/pnas.2008980117","volume":"117","author":"EC Warren","year":"2020","unstructured":"Warren EC, Dooves S, Lugar\u00e0 E et al (2020) Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling. Proc Natl Acad Sci U S A 117:23617\u201323625. https:\/\/doi.org\/10.1073\/pnas.2008980117","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4691_CR53","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/S1474-4422(17)30408-8","volume":"17","author":"K Augustin Bsc","year":"2018","unstructured":"Augustin Bsc K, Khabbush Phd A, Phd SW et al (2018) Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders. Lancet Neurol 17:84\u201393. https:\/\/doi.org\/10.1016\/S1474-4422(17)30408-8","journal-title":"Lancet Neurol"},{"issue":"12","key":"4691_CR54","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.3390\/antiox10121991","volume":"10","author":"J Mett","year":"2021","unstructured":"Mett J (2021) The impact of medium chain and polyunsaturated \u03c9-3\u2010fatty acids on amyloid\u2010\u03b2 deposition, oxidative stress and metabolic dysfunction associated with Alzheimer\u2019s disease. Antioxidants 10(12):1991","journal-title":"Antioxidants"},{"key":"4691_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-018-29792-x","volume":"8","author":"J Pido-Lopez","year":"2018","unstructured":"Pido-Lopez J, Andre R, Benjamin AC et al (2018) In vivo neutralization of the protagonist role of macrophages during the chronic inflammatory stage of Huntington\u2019s disease. Sci Rep 8:1\u201314. https:\/\/doi.org\/10.1038\/s41598-018-29792-x","journal-title":"Sci Rep"},{"key":"4691_CR56","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.nbd.2015.08.011","volume":"83","author":"M Politis","year":"2015","unstructured":"Politis M, Lahiri N, Niccolini F et al (2015) Increased central microglial activation associated with peripheral cytokine levels in premanifest Huntington\u2019s disease gene carriers. Neurobiol Dis 83:115\u2013121. https:\/\/doi.org\/10.1016\/j.nbd.2015.08.011","journal-title":"Neurobiol Dis"},{"key":"4691_CR57","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1093\/brain\/awt355","volume":"137","author":"U Tr\u00e4ger","year":"2014","unstructured":"Tr\u00e4ger U, Andre R, Lahiri N et al (2014) HTT-lowering reverses huntington\u2019s disease immune dysfunction caused by NF\u03baB pathway dysregulation. Brain 137:819\u2013833","journal-title":"Brain"},{"key":"4691_CR58","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/S1474-4422(17)30280-6","volume":"16","author":"EJ Wild","year":"2017","unstructured":"Wild EJ, Tabrizi SJ (2017) Therapies targeting DNA and RNA in Huntington\u2019s disease. Lancet Neurol 16:837\u2013847.","journal-title":"Lancet Neurol"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-026-04691-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-026-04691-0","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-026-04691-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:11:18Z","timestamp":1772619078000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-026-04691-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["4691"],"URL":"https:\/\/doi.org\/10.1007\/s11064-026-04691-0","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"6 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"65"}}