{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T05:42:39Z","timestamp":1777268559096,"version":"3.51.4"},"reference-count":72,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T00:00:00Z","timestamp":1773187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1007\/s11064-026-04713-x","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T08:44:21Z","timestamp":1773218661000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroprotective Role of Morin Hydrate in Stress\u2013Re-stress (SRS) Rat Model of PTSD: Mitigation of Cognitive Dysfunction, Anxiety, and Depression via Regulation of Oxidative Stress and Neuroinflammation"],"prefix":"10.1007","volume":"51","author":[{"given":"Sri Ram","family":"Mamidi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi Chandra Sekhara Reddy","family":"Danduga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,3,11]]},"reference":[{"issue":"7","key":"4713_CR1","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1016\/j.biopsych.2021.12.012","volume":"91","author":"MA Waszczuk","year":"2022","unstructured":"Waszczuk MA (2022) Insights from dimensional phenotypic definitions of posttraumatic stress disorder and trauma in genome-wide association studies. Biol Psychiatry 91(7):609\u2013611","journal-title":"Biol Psychiatry"},{"issue":"04","key":"4713_CR2","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1142\/S0219635213500313","volume":"12","author":"TE Ceremuga","year":"2013","unstructured":"Ceremuga TE, Shellabarger P, Persson T, Fanning M, Galey P, Robinson D et al (2013) Effects of tetrahydropalmatine on post-traumatic stress disorder-induced changes in rat brain gene expression. J Integr Neurosci 12(04):513\u2013528","journal-title":"J Integr Neurosci"},{"key":"4713_CR3","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.psychres.2018.12.094","volume":"273","author":"SP Byrne","year":"2019","unstructured":"Byrne SP, Harpaz-Rotem I, Tsai J, Southwick SM, Pietrzak RH (2019) Latent typologies of DSM-5 PTSD symptoms in U.S. military veterans. Psychiatry Res 273:266\u2013273","journal-title":"Psychiatry Res"},{"issue":"2","key":"4713_CR4","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.chest.2018.04.007","volume":"154","author":"AA El-Solh","year":"2018","unstructured":"El-Solh AA, Riaz U, Roberts J (2018) Sleep disorders in patients with posttraumatic stress disorder. Chest 154(2):427\u2013439","journal-title":"Chest"},{"issue":"5","key":"4713_CR5","doi-asserted-by":"publisher","first-page":"525","DOI":"10.4196\/kjpp.2018.22.5.525","volume":"22","author":"B Lee","year":"2018","unstructured":"Lee B, Shim I, Lee H, Hahm DH (2018) Tetramethylpyrazine reverses anxiety-like behaviors in a rat model of post-traumatic stress disorder. Korean J Physiol Pharmacol 22(5):525\u2013538","journal-title":"Korean J Physiol Pharmacol"},{"key":"4713_CR6","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.bbrc.2023.06.004","volume":"671","author":"T Mei","year":"2023","unstructured":"Mei T, Ma L, Kong F (2023) Sodium aescinate improve behavioral performance by inhibiting dorsal raphe nucleus NLRP3 inflammasome in post-traumatic stress disorder rat model. Biochem Biophys Res Commun 671:166\u2013172","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"4713_CR7","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1176\/appi.ajp.161.8.1397","volume":"161","author":"R Yehuda","year":"2004","unstructured":"Yehuda R, Golier JA, Halligan SL, Meaney M, Bierer LM (2004) The ACTH response to dexamethasone in PTSD. Am J Psychiatry 161(8):1397\u20131403","journal-title":"Am J Psychiatry"},{"issue":"6","key":"4713_CR8","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.jpsychires.2005.08.002","volume":"40","author":"CS de Kloet","year":"2006","unstructured":"de Kloet CS, Vermetten E, Geuze E, Kavelaars A, Heijnen CJ, Westenberg HGM (2006) Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review. J Psychiatr Res 40(6):550\u201367","journal-title":"J Psychiatr Res"},{"issue":"2","key":"4713_CR9","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.psyneuen.2004.07.001","volume":"30","author":"A Shea","year":"2005","unstructured":"Shea A, Walsh C, MacMillan H, Steiner M (2005) Child maltreatment and HPA axis dysregulation: relationship to major depressive disorder and post traumatic stress disorder in females. Psychoneuroendocrinology 30(2):162\u2013178","journal-title":"Psychoneuroendocrinology"},{"issue":"Suppl 5","key":"4713_CR10","first-page":"24","volume":"61","author":"DJ Nutt","year":"2000","unstructured":"Nutt DJ (2000) The psychobiology of posttraumatic stress disorder. J Clin Psychiatry 61(Suppl 5):24\u201329 discussion 30\u2009\u2013\u20092","journal-title":"J Clin Psychiatry"},{"issue":"11","key":"4713_CR11","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1038\/mp.2014.111","volume":"19","author":"MW Miller","year":"2014","unstructured":"Miller MW, Sadeh N (2014) Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis. Mol Psychiatry 19(11):1156\u20131162","journal-title":"Mol Psychiatry"},{"issue":"5","key":"4713_CR12","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3390\/biomedicines10050953","volume":"10","author":"DH Lee","year":"2022","unstructured":"Lee DH, Lee JY, Hong DY, Lee EC, Park SW, Lee MR et al (2022) Neuroinflammation in Post-Traumatic Stress Disorder. Biomedicines 10(5):953","journal-title":"Biomedicines"},{"issue":"Suppl 2","key":"4713_CR13","first-page":"34","volume":"67","author":"JRT Davidson","year":"2006","unstructured":"Davidson JRT (2006) Pharmacologic treatment of acute and chronic stress following trauma: 2006. J Clin Psychiatry 67(Suppl 2):34\u201339","journal-title":"J Clin Psychiatry"},{"issue":"5","key":"4713_CR14","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.biopsych.2008.10.034","volume":"65","author":"N Kozlovsky","year":"2009","unstructured":"Kozlovsky N, Matar MA, Kaplan Z, Zohar J, Cohen H (2009) The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder. Biol Psychiatry 65(5):383\u2013391","journal-title":"Biol Psychiatry"},{"key":"4713_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2023.109728","volume":"240","author":"XD Chen","year":"2023","unstructured":"Chen XD, Wei JX, Wang HY, Peng YY, Tang C, Ding Y et al (2023) Effects and mechanisms of salidroside on the behavior of SPS-induced PTSD rats. Neuropharmacology 240:109728","journal-title":"Neuropharmacology"},{"issue":"7","key":"4713_CR16","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1007\/s10072-014-1628-5","volume":"35","author":"MS Ola","year":"2014","unstructured":"Ola MS, Aleisa AM, Al-Rejaie SS, Abuohashish HM, Parmar MY, Alhomida AS et al (2014) Flavonoid, morin inhibits oxidative stress, inflammation and enhances neurotrophic support in the brain of streptozotocin-induced diabetic rats. Neurol Sci 35(7):1003\u20131008","journal-title":"Neurol Sci"},{"issue":"8","key":"4713_CR17","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1177\/0960327111431090","volume":"31","author":"A Merwid-L\u0105d","year":"2012","unstructured":"Merwid-L\u0105d A, Trocha M, Chlebda E, Soza\u0144ski T, Magdalan J, Ksi\u0105dzyna D et al (2012) Effects of morin-5\u2032-sulfonic acid sodium salt (NaMSA) on cyclophosphamide-induced changes in oxido-redox state in rat liver and kidney. Hum Exp Toxicol 31(8):812\u2013819","journal-title":"Hum Exp Toxicol"},{"issue":"7","key":"4713_CR18","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1007\/s11011-020-00595-2","volume":"35","author":"A Elizabeth","year":"2020","unstructured":"Elizabeth A, Adegbuyi A, Olusegun A, Benneth BA, Anthony E, Abayomi A et al (2020) Morin hydrate attenuates chronic stress-induced memory impairment and degeneration of hippocampal subfields in mice: The role of oxidative, nitrergic and neuroinflammatory pathways. Metab Brain Dis 35(7):1145\u20131156","journal-title":"Metab Brain Dis"},{"issue":"8","key":"4713_CR19","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/aps.2010.77","volume":"31","author":"Z Zhang","year":"2010","unstructured":"Zhang Z, Cao X, Xiong N, Wang H, Huang J, Sun S et al (2010) Morin exerts neuroprotective actions in Parkinson disease models in vitro and in vivo. Acta Pharmacol Sin 31(8):900\u20136","journal-title":"Acta Pharmacol Sin"},{"key":"4713_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuropharm.2016.04.008","volume":"108","author":"Y Du","year":"2016","unstructured":"Du Y, Qu J, Zhang W, Bai M, Zhou Q, Zhang Z et al (2016) Morin reverses neuropathological and cognitive impairments in APPswe\/PS1dE9 mice by targeting multiple pathogenic mechanisms. Neuropharmacology 108:1\u201313","journal-title":"Neuropharmacology"},{"issue":"2","key":"4713_CR21","doi-asserted-by":"publisher","first-page":"348","DOI":"10.21010\/ajtcam.v14i2.36","volume":"14","author":"Y Chen","year":"2017","unstructured":"Chen Y, Li Y, Xu H, Li G, Ma Y, Pang YJ (2017) MORIN MITIGATES OXIDATIVE STRESS, APOPTOSIS AND INFLAMMATION IN CEREBRAL ISCHEMIC RATS. Afr J Tradit Complement Altern Med 14(2):348\u2013355","journal-title":"Afr J Tradit Complement Altern Med"},{"issue":"3","key":"4713_CR22","doi-asserted-by":"publisher","first-page":"195","DOI":"10.29252\/nirp.bcn.9.3.195","volume":"9","author":"ET Olonode","year":"2018","unstructured":"Olonode ET, Aderibigbe AO, Adeoluwa OA, Ajayi AM (2018) Protective effects of morin hydrate on acute stress-induced behavioral and biochemical alterations in mice. Basic Clin Neurosci 9(3):195\u2013208","journal-title":"Basic Clin Neurosci"},{"key":"4713_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114140","volume":"180","author":"MAM Hassan","year":"2020","unstructured":"Hassan MAM, Gad AM, Menze ET, Badary OA, El-Naga RN (2020) Protective effects of morin against depressive-like behavior prompted by chronic unpredictable mild stress in rats: Possible role of inflammasome-related pathways. Biochem Pharmacol 180:114140","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"4713_CR24","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/0031-9384(93)90050-P","volume":"54","author":"RE Adamec","year":"1993","unstructured":"Adamec RE, Shallow T (1993) Lasting effects on rodent anxiety of a single exposure to a cat. Physiol Behav 54(1):101\u2013109","journal-title":"Physiol Behav"},{"issue":"9","key":"4713_CR25","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1080\/00207454.2019.1711078","volume":"130","author":"SK Prajapati","year":"2020","unstructured":"Prajapati SK, Singh N, Garabadu D, Krishnamurthy S (2020) A novel stress re-stress model: modification of re-stressor cue induces long-lasting post-traumatic stress disorder-like symptoms in rats. Int J Neurosci 130(9):941\u2013952","journal-title":"Int J Neurosci"},{"key":"4713_CR26","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.neuropharm.2013.07.005","volume":"75","author":"S Krishnamurthy","year":"2013","unstructured":"Krishnamurthy S, Garabadu D, Joy KP (2013) Risperidone ameliorates post-traumatic stress disorder-like symptoms in modified stress re-stress model. Neuropharmacology 75:62\u201377","journal-title":"Neuropharmacology"},{"issue":"7","key":"4713_CR27","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/0006-3223(93)90001-T","volume":"33","author":"R Yehuda","year":"1993","unstructured":"Yehuda R, Antelman SM (1993) Criteria for rationally evaluating animal models of postraumatic stress disorder. Biol Psychiatry 33(7):479\u2013486","journal-title":"Biol Psychiatry"},{"issue":"5","key":"4713_CR28","doi-asserted-by":"publisher","first-page":"851","DOI":"10.2105\/AJPH.2004.054171","volume":"95","author":"SM Manson","year":"2005","unstructured":"Manson SM, Beals J, Klein SA, Croy CD (2005) Social epidemiology of trauma among 2 American Indian reservation populations. Am J Public Health 95(5):851\u2013859","journal-title":"Am J Public Health"},{"issue":"9","key":"4713_CR29","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1093\/jpp\/rgad022","volume":"75","author":"RCSR Danduga","year":"2023","unstructured":"Danduga RCSR, Shaik HB, Polopalli S, Kola PK, Kanakaraju VK, Kandaswamy S (2023) Tetramethylpyrazine contributes to the neuroprotection in a rodent epileptic model of pentylenetetrazole-induced kindling. J Pharm Pharmacol 75(9):1163\u20131176","journal-title":"J Pharm Pharmacol"},{"issue":"3","key":"4713_CR30","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/da.20803","volume":"28","author":"J D\u0119biec","year":"2011","unstructured":"D\u0119biec J, Bush DEA, LeDoux JE (2011) Noradrenergic enhancement of reconsolidation in the amygdala impairs extinction of conditioned fear in rats-a possible mechanism for the persistence of traumatic memories in PTSD. Depress Anxiety 28(3):186\u2013193","journal-title":"Depress Anxiety"},{"issue":"1","key":"4713_CR31","doi-asserted-by":"publisher","first-page":"9041309","DOI":"10.1155\/2018\/9041309","volume":"2018","author":"B Lee","year":"2018","unstructured":"Lee B, Lee H (2018) Systemic administration of curcumin affect anxiety-related behaviors in a rat model of posttraumatic stress disorder via activation of serotonergic systems. Evidence-Based Complement Altern Med 2018(1):9041309","journal-title":"Evidence-Based Complement Altern Med"},{"key":"4713_CR32","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.bbr.2018.12.037","volume":"361","author":"VM Magdaleno-Madrigal","year":"2019","unstructured":"Magdaleno-Madrigal VM, Morales-Mulia S, Nicolini H, Genis-Mendoza A, C\u00e1zares-Mart\u00ednez EC, P\u00e9rez-Luna MJ et al (2019) Orexin-A promotes EEG changes but fails to induce anxiety in rats. Behav Brain Res 361:26\u201331","journal-title":"Behav Brain Res"},{"key":"4713_CR33","first-page":"93","volume-title":"Elevated plus maze for assessment of anxiety and memory in rodents","author":"RCSR Danduga","year":"2024","unstructured":"Danduga RCSR, Kola PK (2024) Elevated plus maze for assessment of anxiety and memory in rodents. Springer, New york, pp 93\u201396"},{"issue":"4","key":"4713_CR34","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1080\/13880200701214631","volume":"45","author":"M Vasudevan","year":"2007","unstructured":"Vasudevan M, Parle M (2007) Memory-Enhancing Activity of Thespesia populnea. in Rats. Pharm Biol 45(4):267\u2013273","journal-title":"Pharm Biol"},{"issue":"6","key":"4713_CR35","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1016\/j.eplepsyres.2014.04.003","volume":"108","author":"JN Pearson","year":"2014","unstructured":"Pearson JN, Schulz KM, Patel M (2014) Specific alterations in the performance of learning and memory tasks in models of chemoconvulsant-induced status epilepticus. Epilepsy Res 108(6):1032\u20131040","journal-title":"Epilepsy Res"},{"key":"4713_CR36","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.npbr.2019.07.006","volume":"33","author":"RCSR Danduga","year":"2019","unstructured":"Danduga RCSR, Dondapati SR, Kola PK, Kavati SSH, Singapalli MS (2019) Combination effect of Aspirin and N-acetylcysteine against global cerebral ischemic reperfusion injury in rats. Neurol Psychiatry Brain Res 33:101\u2013111","journal-title":"Neurol Psychiatry Brain Res"},{"key":"4713_CR37","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.biopha.2018.06.079","volume":"105","author":"RCSR Danduga","year":"2018","unstructured":"Danduga RCSR, Dondapati SR, Kola PK, Grace L, Tadigiri RVB, Kanakaraju VK (2018) Neuroprotective activity of tetramethylpyrazine against 3-nitropropionic acid induced Huntington\u2019s disease-like symptoms in rats. Biomed Pharmacother 105:1254\u20131268","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"4713_CR38","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","volume":"95","author":"H Ohkawa","year":"1979","unstructured":"Ohkawa H, Ohishi N, Yagi K (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95(2):351\u2013358","journal-title":"Anal Biochem"},{"issue":"1","key":"4713_CR39","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","volume":"82","author":"GL Ellman","year":"1959","unstructured":"Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82(1):70\u201377","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"4713_CR40","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","volume":"47","author":"S MARKLUND","year":"1974","unstructured":"MARKLUND S (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47(3):469\u2013474","journal-title":"Eur J Biochem"},{"issue":"1","key":"4713_CR41","doi-asserted-by":"publisher","first-page":"57","DOI":"10.4067\/S0716-97602009000100006","volume":"42","author":"C Fern\u00e1ndez","year":"2009","unstructured":"Fern\u00e1ndez C, San Miguel E, Fern\u00e1ndez-Briera A (2009) Superoxide dismutase and catalase: tissue activities and relation with age in the long-lived species Margaritifera margaritifera. Biol Res 42(1):57\u201368","journal-title":"Biol Res"},{"issue":"2","key":"4713_CR42","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","volume":"7","author":"GL Ellman","year":"1961","unstructured":"Ellman GL, Courtney KD, Andres V, Featherstone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7(2):88\u201395","journal-title":"Biochem Pharmacol"},{"key":"4713_CR43","doi-asserted-by":"publisher","first-page":"1281401","DOI":"10.3389\/fnins.2023.1281401","volume":"17","author":"J Iqbal","year":"2023","unstructured":"Iqbal J, Huang GD, Xue YX, Yang M, Jia XJ (2023) The neural circuits and molecular mechanisms underlying fear dysregulation in posttraumatic stress disorder. Front Neurosci 17:1281401","journal-title":"Front Neurosci"},{"issue":"1","key":"4713_CR44","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s41235-022-00386-6","volume":"7","author":"BL Pitts","year":"2022","unstructured":"Pitts BL, Eisenberg ML, Bailey HR, Zacks JM (2022) PTSD is associated with impaired event processing and memory for everyday events. Cogn Res Princ Implic 7(1):35","journal-title":"Cogn Res Princ Implic"},{"issue":"10","key":"4713_CR45","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1038\/npp.2015.95","volume":"40","author":"LA Johnson","year":"2015","unstructured":"Johnson LA, Zuloaga DG, Bidiman E, Marzulla T, Weber S, Wahbeh H et al (2015) ApoE2 exaggerates PTSD-related behavioral, cognitive, and neuroendocrine alterations. Neuropsychopharmacology 40(10):2443\u201353","journal-title":"Neuropsychopharmacology"},{"key":"4713_CR46","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.lfs.2014.11.026","volume":"121","author":"J Gao","year":"2015","unstructured":"Gao J, Chen C, Liu Y, Li Y, Long Z, Wang H et al (2015) Lycium barbarum polysaccharide improves traumatic cognition via reversing imbalance of apoptosis\/regeneration in hippocampal neurons after stress. Life Sci 121:124\u201334","journal-title":"Life Sci"},{"issue":"1","key":"4713_CR47","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1002\/cne.1190","volume":"435","author":"JN Marcus","year":"2001","unstructured":"Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M et al (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435(1):6\u201325","journal-title":"J Comp Neurol"},{"issue":"1","key":"4713_CR48","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.explore.2016.10.001","volume":"13","author":"B Sebastian","year":"2017","unstructured":"Sebastian B, Nelms J (2017) The effectiveness of emotional freedom techniques in the treatment of posttraumatic stress disorder: a meta-analysis. EXPLORE 13(1):16\u201325","journal-title":"EXPLORE"},{"key":"4713_CR49","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.bbr.2017.12.024","volume":"356","author":"ET Olonode","year":"2019","unstructured":"Olonode ET, Aderibigbe AO, Adeoluwa OA, Eduviere AT, Ben-Azu B (2019) Morin hydrate mitigates rapid eye movement sleep deprivation-induced neurobehavioural impairments and loss of viable neurons in the hippocampus of mice. Behav Brain Res 356:518\u2013525","journal-title":"Behav Brain Res"},{"issue":"1","key":"4713_CR50","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/s41398-023-02660-7","volume":"13","author":"MSC Sep","year":"2023","unstructured":"Sep MSC, Geuze E, Jo\u00ebls M (2023) Impaired learning, memory, and extinction in posttraumatic stress disorder: translational meta-analysis of clinical and preclinical studies. Transl Psychiatry 13(1):376","journal-title":"Transl Psychiatry"},{"issue":"34","key":"4713_CR51","doi-asserted-by":"publisher","first-page":"4051","DOI":"10.2174\/1381612824666181120094749","volume":"24","author":"M He","year":"2019","unstructured":"He M, Wei JX, Mao M, Zhao GY, Tang JJ, Feng S et al (2019) Synaptic Plasticity in PTSD and associated Comorbidities: The Function and Mechanism for Diagnostics and Therapy. Curr Pharm Des 24(34):4051\u20134059","journal-title":"Curr Pharm Des"},{"key":"4713_CR52","doi-asserted-by":"publisher","first-page":"2394","DOI":"10.3389\/fpsyg.2019.02394","volume":"10","author":"HH Zhang","year":"2019","unstructured":"Zhang HH, Meng SQ, Guo XY, Zhang JL, Zhang W, Chen YY et al (2019) Traumatic stress produces delayed alterations of synaptic plasticity in basolateral amygdala. Front Psychol 10:2394","journal-title":"Front Psychol"},{"issue":"4","key":"4713_CR53","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1080\/19768354.2022.2104925","volume":"26","author":"B Sur","year":"2022","unstructured":"Sur B, Lee B (2022) Luteolin reduces fear, anxiety, and depression in rats with post-traumatic stress disorder. Anim Cells Syst (Seoul) 26(4):174\u2013182","journal-title":"Anim Cells Syst (Seoul)"},{"key":"4713_CR54","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.biopha.2018.06.057","volume":"105","author":"B Ben-Azu","year":"2018","unstructured":"Ben-Azu B, Aderibigbe AO, Omogbiya IA, Ajayi AM, Owoeye O, Olonode ET et al (2018) Probable mechanisms involved in the antipsychotic-like activity of morin in mice. Biomedicine & Pharmacotherapy 105:1079\u201390","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"2","key":"4713_CR55","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1007\/s43440-020-00198-9","volume":"73","author":"SK Prajapati","year":"2021","unstructured":"Prajapati SK, Krishnamurthy S (2021) Development and treatment of cognitive inflexibility in sub-chronic stress\u2013re-stress (SRS) model of PTSD. Pharmacol Rep 73(2):464\u2013479","journal-title":"Pharmacol Rep"},{"issue":"1","key":"4713_CR56","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s12974-019-1412-9","volume":"16","author":"DJ Finneran","year":"2019","unstructured":"Finneran DJ, Nash KR (2019) Neuroinflammation and fractalkine signaling in Alzheimer\u2019s disease. J Neuroinflammation 16(1):30","journal-title":"J Neuroinflammation"},{"issue":"4","key":"4713_CR57","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1007\/s12035-020-02213-9","volume":"58","author":"Z Zhang","year":"2021","unstructured":"Zhang Z, Song Z, Shen F, Xie P, Wang J, Zhu A, song et al (2021) Ginsenoside Rg1 Prevents PTSD-Like Behaviors in Mice Through Promoting Synaptic Proteins, Reducing Kir4.1 and TNF-\u03b1 in the Hippocampus. Mol Neurobiol 58(4):1550\u20131563","journal-title":"Mol Neurobiol"},{"key":"4713_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2020.113026","volume":"224","author":"F Li","year":"2020","unstructured":"Li F, Xiang H, Lu J, Chen Z, Huang C, Yuan X (2020) Lycopene ameliorates PTSD-like behaviors in mice and rebalances the neuroinflammatory response and oxidative stress in the brain. Physiol Behav 224:113026","journal-title":"Physiol Behav"},{"key":"4713_CR59","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.jad.2019.01.029","volume":"248","author":"W Wang","year":"2019","unstructured":"Wang W, Wang L, Xu H, Cao C, Liu P, Luo S et al (2019) Characteristics of pro- and anti-inflammatory cytokines alteration in PTSD patients exposed to a deadly earthquake. J Affect Disord 248:52\u20138","journal-title":"J Affect Disord"},{"key":"4713_CR60","doi-asserted-by":"publisher","DOI":"10.1177\/1744806916679166","author":"R Sun","year":"2016","unstructured":"Sun R, Zhang Z, Lei Y, Liu Y, Lu C, Rong H et al (2016) Hippocampal activation of microglia may underlie the shared neurobiology of comorbid posttraumatic stress disorder and chronic pain. Mol Pain. https:\/\/doi.org\/10.1177\/1744806916679166","journal-title":"Mol Pain"},{"key":"4713_CR61","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2024.107261","volume":"172","author":"L Wang","year":"2025","unstructured":"Wang L, Xu Y, Jiang M, Wang M, Ji M, Xie X et al (2025) Chronic stress induces depression-like behavior in rats through affecting brain mitochondrial function and inflammation. Psychoneuroendocrinology 172:107261","journal-title":"Psychoneuroendocrinology"},{"issue":"10","key":"4713_CR62","doi-asserted-by":"publisher","first-page":"5085","DOI":"10.3390\/ijms25105085","volume":"25","author":"AG White","year":"2024","unstructured":"White AG, Elias E, Orozco A, Robinson SA, Manners MT (2024) Chronic Stress-Induced Neuroinflammation: Relevance of Rodent Models to Human Disease. Int J Mol Sci 25(10):5085","journal-title":"Int J Mol Sci"},{"issue":"2","key":"4713_CR63","doi-asserted-by":"publisher","first-page":"75","DOI":"10.5567\/pharmacologia.2016.75.82","volume":"7","author":"DSK Dhingra","year":"2016","unstructured":"Dhingra DSK (2016) Improvement of learning and memory by Morin, a flavonoid in young and aged mice. Pharmacologia 7(2):75\u201382","journal-title":"Pharmacologia"},{"issue":"1","key":"4713_CR64","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s10020-025-01172-y","volume":"31","author":"EM Elbaz","year":"2025","unstructured":"Elbaz EM, Sayed RH, Abdelkader AA, Fahim AT (2025) Neuroprotective role of morin hydrate on 3-nitropropionic acid-elicited huntington\u2019s disease: in vivo investigation of RIPK1\/RIPK3\/MLKL necroptosis signaling pathway. Mol Med 31(1):135","journal-title":"Mol Med"},{"key":"4713_CR65","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.biopha.2018.06.161","volume":"106","author":"M Kuzu","year":"2018","unstructured":"Kuzu M, Kandemir FM, Yildirim S, Kucukler S, Caglayan C, Turk E (2018) Morin attenuates doxorubicin-induced heart and brain damage by reducing oxidative stress, inflammation and apoptosis. Biomed Pharmacother 106:443\u2013453","journal-title":"Biomed Pharmacother"},{"key":"4713_CR66","first-page":"865","volume":"3","author":"C Cunha","year":"2010","unstructured":"Cunha C et al (2010) A simple role for BDNF in learning and memory? Front Mol Neurosci 3:865","journal-title":"Front Mol Neurosci"},{"issue":"4","key":"4713_CR67","doi-asserted-by":"publisher","first-page":"652","DOI":"10.3390\/jpm13040652","volume":"13","author":"A Pisani","year":"2023","unstructured":"Pisani A, Paciello F, Del Vecchio V, Malesci R, De Corso E, Cantone E et al (2023) The Role of BDNF as a Biomarker in Cognitive and Sensory Neurodegeneration. J Pers Med 13(4):652","journal-title":"J Pers Med"},{"issue":"2","key":"4713_CR68","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.pbb.2003.10.020","volume":"77","author":"AA Garza","year":"2004","unstructured":"Garza AA, Ha TG, Garcia C, Chen MJ, Russo-Neustadt AA (2004) Exercise, antidepressant treatment, and BDNF mRNA expression in the aging brain. Pharmacol Biochem Behav 77(2):209\u2013220","journal-title":"Pharmacol Biochem Behav"},{"issue":"11","key":"4713_CR69","doi-asserted-by":"publisher","first-page":"2802","DOI":"10.1021\/bi00463a024","volume":"29","author":"JB Mitchell","year":"1990","unstructured":"Mitchell JB, Samuni A, Krishna MC, DeGraff WG, Ahn MS, Samuni U et al (1990) Biologically active metal-independent superoxide dismutase mimics. Biochemistry 29(11):2802\u20132807","journal-title":"Biochemistry"},{"issue":"2","key":"4713_CR70","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1124\/pr.111.005108","volume":"64","author":"AE Autry","year":"2012","unstructured":"Autry AE, Monteggia LM (2012) Brain-derived neurotrophic factor and neuropsychiatric disorders. Pharmacol Rev 64(2):238\u2013258","journal-title":"Pharmacol Rev"},{"key":"4713_CR71","doi-asserted-by":"publisher","first-page":"1266575","DOI":"10.3389\/fphys.2023.1266575","volume":"14","author":"H Kmita","year":"2023","unstructured":"Kmita H, Pinna G, Lushchak VI (2023) Potential oxidative stress related targets of mitochondria-focused therapy of PTSD. Front Physiol 14:1266575","journal-title":"Front Physiol"},{"issue":"3","key":"4713_CR72","doi-asserted-by":"publisher","first-page":"393","DOI":"10.32598\/bcn.2022.1059.2","volume":"13","author":"E Akinluyi","year":"2022","unstructured":"Akinluyi E, Aderibigbe A, Adeoluwa O, Adebesin A, Adeoluwa G (2022) Ameliorating effect of morin hydrate on chronic restraint stress-induced biochemical disruption, neuronal, and behavioral dysfunctions in BALB\/c mice. Basic Clin Neurosci 13(3):393\u2013406","journal-title":"Basic Clin Neurosci"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-026-04713-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-026-04713-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-026-04713-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T05:01:50Z","timestamp":1777266110000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-026-04713-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,11]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["4713"],"URL":"https:\/\/doi.org\/10.1007\/s11064-026-04713-x","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,11]]},"assertion":[{"value":"11 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 February 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"104"}}