{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:45:08Z","timestamp":1782755108592,"version":"3.54.5"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100014759","name":"Medical Scientific Research Foundation of Zhejiang Province, China","doi-asserted-by":"publisher","award":["2025KY254"],"award-info":[{"award-number":["2025KY254"]}],"id":[{"id":"10.13039\/501100014759","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005315","name":"Natural Science Foundation of Ningbo Municipality","doi-asserted-by":"publisher","award":["2023J165"],"award-info":[{"award-number":["2023J165"]}],"id":[{"id":"10.13039\/501100005315","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ningbo Top Medical and Health Research Program","award":["2022020304"],"award-info":[{"award-number":["2022020304"]}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LMRY27H090007"],"award-info":[{"award-number":["LMRY27H090007"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1007\/s11064-026-04799-3","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T03:00:36Z","timestamp":1780282836000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Herkinorin Exerted Neuroprotective Effects After Spinal Cord Injury by Suppression of NF-\u03baB Pathway Activation"],"prefix":"10.1007","volume":"51","author":[{"given":"Jianyong","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiacheng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaochao","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaiFeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"issue":"11","key":"4799_CR1","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/S1474-4422(23)00287-9","volume":"22","author":"M Safdarian","year":"2023","unstructured":"Safdarian M, Trinka E, Rahimi-Movaghar V, Thomschewski A, Aali A, Abady GG, Abate SM, Abd-Allah F, Abedi A, Adane DE, Afzal S (2023) Global, regional, and national burden of spinal cord injury, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol 22(11):1026\u20131047","journal-title":"Lancet Neurol"},{"issue":"6","key":"4799_CR2","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/s41580-022-00562-y","volume":"24","author":"B Zheng","year":"2023","unstructured":"Zheng B, Tuszynski MH (2023) Regulation of axonal regeneration after mammalian spinal cord injury. Nat Rev Mol Cell Biol 24(6):396\u2013413","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"4799_CR3","first-page":"466","volume":"31","author":"P Muangsanit","year":"2025","unstructured":"Muangsanit P, Yuddnaraveesak P, Singhatanadgit W (2025) Regenerative potential of neural stem\/progenitor cells for bone repair. Tissue Eng B Rev 31(5):466\u2013478","journal-title":"Tissue Eng B Rev"},{"key":"4799_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122002","volume":"295","author":"S Hashimoto","year":"2023","unstructured":"Hashimoto S, Nagoshi N, Shinozaki M, Nakanishi K, Suematsu Y, Shibata T, Kawai M, Kitagawa T, Ago K, Kamata Y, Yasutake K, Koya I, Ando Y, Minoda A, Shindo T, Shibata S, Matsumoto M, Nakamura M, Okano H (2023) Microenvironmental modulation in tandem with human stem cell transplantation enhances functional recovery after chronic complete spinal cord injury. Biomaterials 295:122002","journal-title":"Biomaterials"},{"issue":"1","key":"4799_CR5","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41392-023-01477-6","volume":"8","author":"X Hu","year":"2023","unstructured":"Hu X, Xu W, Ren Y, Wang Z, He X, Huang R, Ma B, Zhao J, Zhu R, Cheng L (2023) Spinal cord injury: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther 8(1):245","journal-title":"Signal Transduct Target Ther"},{"issue":"2","key":"4799_CR6","doi-asserted-by":"publisher","first-page":"2812","DOI":"10.1021\/acsnano.0c08727","volume":"15","author":"R Zhu","year":"2021","unstructured":"Zhu R, Zhu X, Zhu Y, Wang Z, He X, Wu Z, Xue L, Fan W, Huang R, Xu Z, Qi X, Xu W, Yu Y, Ren Y, Li C, Cheng Q, Ling L, Wang S, Cheng L (2021) Immunomodulatory layered double hydroxide nanoparticles enable neurogenesis by targeting transforming growth factor-\u03b2 receptor 2. ACS Nano 15(2):2812\u20132830","journal-title":"ACS Nano"},{"issue":"6","key":"4799_CR7","doi-asserted-by":"publisher","first-page":"2398","DOI":"10.1038\/s41380-023-02052-9","volume":"28","author":"X Yang","year":"2023","unstructured":"Yang X, Tohda C (2023) Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer\u2019s disease model mice. Mol Psychiatry 28(6):2398\u20132411","journal-title":"Mol Psychiatry"},{"issue":"1","key":"4799_CR8","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30102-8","volume":"8","author":"X Yang","year":"2018","unstructured":"Yang X, Tohda C (2018) Diosgenin restores A\u03b2-induced axonal degeneration by reducing the expression of heat shock cognate 70 (HSC70). Sci Rep 8(1):11707","journal-title":"Sci Rep"},{"issue":"3","key":"4799_CR9","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/ptr.1090","volume":"17","author":"SR Lee","year":"2003","unstructured":"Lee SR, Im KJ, Suh SI, Jung JG (2003) Protective effect of green tea polyphenol (-)-epigallocatechin gallate and other antioxidants on lipid peroxidation in gerbil brain homogenates. Phytother Res 17(3):206\u2013209","journal-title":"Phytother Res"},{"issue":"8","key":"4799_CR10","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1016\/S1474-4422(23)00215-6","volume":"22","author":"G Maynard","year":"2023","unstructured":"Maynard G, Kannan R, Liu J, Wang W, Lam TKT, Wang X, Adamson C, Hackett C, Schwab JM, Liu C, Leslie DP, Chen D, Marino R, Zafonte R, Flanders A, Block G, Smith E, Strittmatter SM (2023) Soluble Nogo-Receptor-Fc decoy (AXER-204) in patients with chronic cervical spinal cord injury in the USA: a first-in-human and randomised clinical trial. Lancet Neurol 22(8):672\u2013684","journal-title":"Lancet Neurol"},{"issue":"1","key":"4799_CR11","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/sc.2013.137","volume":"52","author":"DD Cardenas","year":"2014","unstructured":"Cardenas DD, Ditunno JF, Graziani V, McLain AB, Lammertse DP, Potter PJ, Alexander MS, Cohen R, Blight AR (2014) Two phase 3, multicenter, randomized, placebo-controlled clinical trials of fampridine-SR for treatment of spasticity in chronic spinal cord injury. Spinal Cord 52(1):70\u201376","journal-title":"Spinal Cord"},{"issue":"1","key":"4799_CR12","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3171\/2017.11.SPINE17769","volume":"29","author":"N Derakhshanrad","year":"2018","unstructured":"Derakhshanrad N, Saberi H, Yekaninejad MS, Joghataei MT, Sheikhrezaei A (2018) Granulocyte-colony stimulating factor administration for neurological improvement in patients with postrehabilitation chronic incomplete traumatic spinal cord injuries: a double-blind randomized controlled clinical trial. J Neurosurg Spine 29(1):97\u2013107","journal-title":"J Neurosurg Spine"},{"key":"4799_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105065","volume":"146","author":"WAJ Vints","year":"2023","unstructured":"Vints WAJ, Levin O, Masiulis N, Verbunt J, van Laake-Geelen CCM (2023) Myokines may target accelerated cognitive aging in people with spinal cord injury: a systematic and topical review. Neurosci Biobehav Rev 146:105065","journal-title":"Neurosci Biobehav Rev"},{"issue":"9","key":"4799_CR14","doi-asserted-by":"publisher","first-page":"4187","DOI":"10.7150\/thno.49054","volume":"11","author":"H Liu","year":"2021","unstructured":"Liu H, Zhang J, Xu X, Lu S, Yang D, Xie C, Jia M, Zhang W, Jin L, Wang X, Shen X, Li F, Wang W, Bao X, Li S, Zhu M, Wang W, Wang Y, Huang Z, Teng H (2021) SARM1 promotes neuroinflammation and inhibits neural regeneration after spinal cord injury through NF-\u03baB signaling. Theranostics 11(9):4187\u20134206","journal-title":"Theranostics"},{"issue":"1","key":"4799_CR15","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12974-018-1193-6","volume":"15","author":"S Chen","year":"2018","unstructured":"Chen S, Ye J, Chen X, Shi J, Wu W, Lin W, Lin W, Li Y, Fu H, Li S (2018) Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-\u03baB pathway dependent of HDAC3. J Neuroinflammation 15(1):150","journal-title":"J Neuroinflammation"},{"issue":"1","key":"4799_CR16","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02737-5","volume":"22","author":"X Nie","year":"2024","unstructured":"Nie X, Liu Y, Yuan T, Yu T, Yun Z, Xue W, Yu T, An J, Dai A, Wu K, Liu Q (2024) Platelet-rich plasma-derived exosomes promote blood-spinal cord barrier repair and attenuate neuroinflammation after spinal cord injury. J Nanobiotechnology 22(1):456","journal-title":"J Nanobiotechnology"},{"issue":"4","key":"4799_CR17","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s12264-022-00844-7","volume":"38","author":"FJ Zhai","year":"2022","unstructured":"Zhai FJ, Han SP, Song TJ, Huo R, Lan XY, Zhang R, Han JS (2022) Involvement of opioid peptides in the analgesic effect of spinal cord stimulation in a rat model of neuropathic pain. Neurosci Bull 38(4):403\u2013416","journal-title":"Neurosci Bull"},{"issue":"5","key":"4799_CR18","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1111\/bph.16255","volume":"181","author":"Y Chen","year":"2024","unstructured":"Chen Y, Zhang H, Jiang L, Cai W, Kuang J, Geng Y, Xu H, Li Y, Yang L, Cai Y, Wang X, Xiao J, Ni W, Zhou K (2024) DADLE promotes motor function recovery by inhibiting cytosolic phospholipase A(2) mediated lysosomal membrane permeabilization after spinal cord injury. Br J Pharmacol 181(5):712\u2013734","journal-title":"Br J Pharmacol"},{"issue":"1","key":"4799_CR19","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1136\/svn-2023-003080","volume":"10","author":"Z Deng","year":"2025","unstructured":"Deng Z, Chen X, Zhang R, Kong L, Fang Y, Guo J, Shen B, Zhang L (2025) Delta opioid peptide [D-ala2, D-leu5]-Enkephalin\u2019s ability to enhance mitophagy via TRPV4 to relieve ischemia\/reperfusion injury in brain microvascular endothelial cells. Stroke Vasc Neurol 10(1):32\u201344","journal-title":"Stroke Vasc Neurol"},{"key":"4799_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114588","volume":"155","author":"Y Liu","year":"2025","unstructured":"Liu Y, Zhao W, Lv X, Wu G, Zhou X, Tian H, Qv X, Sun H, He Y, Zhang Y, Wang C, Tian J (2025) Herkinorin ameliorates neuronal damage in a pentylenetetrazol-induced epilepsy rat model through altering microglial and astrocytic activation by inhibiting PARP1 and NF-\u03baB. Int Immunopharmacol 155:114588","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"4799_CR21","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3892\/mmr.2016.5995","volume":"15","author":"X Gui","year":"2017","unstructured":"Gui X, Cui X, Wei H, Feng G, Zhang X, He Y, Li J, Li T (2017) cPKC\u03b3 membrane translocation is involved in herkinorin-induced neuroprotection against cerebral ischemia\/reperfusion injury in mice. Mol Med Rep 15(1):221\u2013227","journal-title":"Mol Med Rep"},{"issue":"24","key":"4799_CR22","doi-asserted-by":"publisher","first-page":"3394","DOI":"10.1089\/neu.2018.6364","volume":"36","author":"Y Li","year":"2019","unstructured":"Li Y, Han W, Wu Y, Zhou K, Zheng Z, Wang H, Xie L, Li R, Xu K, Liu Y, Wang X, Xiao J (2019) Stabilization of Hypoxia Inducible Factor-1\u03b1 by Dimethyloxalylglycine promotes recovery from acute spinal cord injury by inhibiting neural apoptosis and enhancing axon regeneration. J Neurotrauma 36(24):3394\u20133409","journal-title":"J Neurotrauma"},{"key":"4799_CR23","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.29929","author":"X Cui","year":"2021","unstructured":"Cui X, Xu X, Ju Z, Wang G, Xi C, Li J (2021) Herkinorin negatively regulates NLRP3 inflammasome to alleviate neuronal ischemic injury through activating Mu opioid receptor and inhibiting the NF-\u03baB pathway. J Cell Biochem. https:\/\/doi.org\/10.1002\/jcb.29929","journal-title":"J Cell Biochem"},{"key":"4799_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2025.104958","volume":"413","author":"Z Peng","year":"2025","unstructured":"Peng Z, Ru D, Leng G, Peng J, Zhang M, Cai B (2025) Apelin-13 enhances neurofunctional recovery and suppresses neuroinflammation via the SIRT1\/NF-\u03baB axis in ischemic stroke. Cell Immunol 413:104958","journal-title":"Cell Immunol"},{"issue":"34","key":"4799_CR25","doi-asserted-by":"publisher","first-page":"9169","DOI":"10.1523\/JNEUROSCI.0612-07.2007","volume":"27","author":"A Ert\u00fcrk","year":"2007","unstructured":"Ert\u00fcrk A, Hellal F, Enes J, Bradke F (2007) Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration. J Neurosci 27(34):9169\u20139180","journal-title":"J Neurosci"},{"issue":"9","key":"4799_CR26","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1021\/acschemneuro.2c00189","volume":"13","author":"R Kulkarni","year":"2022","unstructured":"Kulkarni R, Thakur A, Kumar H (2022) Microtubule dynamics following central and peripheral nervous system axotomy. ACS Chem Neurosci 13(9):1358\u20131369","journal-title":"ACS Chem Neurosci"},{"key":"4799_CR27","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10123186","author":"R Akram","year":"2022","unstructured":"Akram R, Anwar H, Javed MS, Rasul A, Imran A, Malik SA, Raza C, Khan IU, Sajid F, Iman T, Sun T, Han HS, Hussain G (2022) Axonal regeneration: underlying molecular mechanisms and potential therapeutic targets. Biomedicines. https:\/\/doi.org\/10.3390\/biomedicines10123186","journal-title":"Biomedicines"},{"issue":"3","key":"4799_CR28","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.neuron.2016.04.022","volume":"90","author":"Z He","year":"2016","unstructured":"He Z, Jin Y (2016) Intrinsic control of axon regeneration. Neuron 90(3):437\u2013451","journal-title":"Neuron"},{"key":"4799_CR29","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6245","volume":"5","author":"VK Godena","year":"2014","unstructured":"Godena VK, Brookes-Hocking N, Moller A, Shaw G, Oswald M, Sancho RM, Miller CC, Whitworth AJ, De Vos KJ (2014) Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations. Nat Commun 5:5245","journal-title":"Nat Commun"},{"issue":"3","key":"4799_CR30","first-page":"225","volume":"7","author":"S Zeng","year":"2020","unstructured":"Zeng S, Zhong Y, Xiao J, Ji J, Xi J, Wei X, Liu R (2020) Kappa opioid receptor on pulmonary macrophages and immune function. Transl Perioper Pain Med 7(3):225\u2013233","journal-title":"Transl Perioper Pain Med"},{"issue":"1","key":"4799_CR31","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1213\/ANE.0b013e31823a5d36","volume":"114","author":"D Su","year":"2012","unstructured":"Su D, Riley J, Armstead WM, Liu R (2012) Salvinorin A pretreatment preserves cerebrovascular autoregulation after brain hypoxic\/ischemic injury via extracellular signal-regulated kinase\/mitogen-activated protein kinase in piglets. Anesth Analg 114(1):200\u2013204","journal-title":"Anesth Analg"},{"issue":"3","key":"4799_CR32","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1002\/syn.20356","volume":"61","author":"H Xu","year":"2007","unstructured":"Xu H, Partilla JS, Wang X, Rutherford JM, Tidgewell K, Prisinzano TE, Bohn LM, Rothman RB (2007) A comparison of noninternalizing (Herkinorin) and internalizing (DAMGO) Mu-opioid agonists on cellular markers related to opioid tolerance and dependence. Synapse 61(3):166\u2013175","journal-title":"Synapse"},{"issue":"15","key":"4799_CR33","doi-asserted-by":"publisher","first-page":"4765","DOI":"10.1021\/jm048963m","volume":"48","author":"WW Harding","year":"2005","unstructured":"Harding WW, Tidgewell K, Byrd N, Cobb H, Dersch CM, Butelman ER, Rothman RB, Prisinzano TE (2005) Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. J Med Chem 48(15):4765\u20134771","journal-title":"J Med Chem"},{"issue":"3","key":"4799_CR34","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1097\/00000542-200403000-00015","volume":"100","author":"YJ Lim","year":"2004","unstructured":"Lim YJ, Zheng S, Zuo Z (2004) Morphine preconditions Purkinje cells against cell death under in vitro simulated ischemia-reperfusion conditions. Anesthesiology 100(3):562\u2013568","journal-title":"Anesthesiology"},{"issue":"10","key":"4799_CR35","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1097\/01.jnen.0000235123.05677.4b","volume":"65","author":"P Zhao","year":"2006","unstructured":"Zhao P, Huang Y, Zuo Z (2006) Opioid preconditioning induces opioid receptor-dependent delayed neuroprotection against ischemia in rats. J Neuropathol Exp Neurol 65(10):945\u2013952","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1","key":"4799_CR36","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-025-08832-6","volume":"27","author":"EA Alzarea","year":"2025","unstructured":"Alzarea EA, Al-Kuraishy HM, Al-Gareeb AI, Alexiou A, Papadakis M, Beshay ON, Batiha GE (2025) The conceivable role of metabolic syndrome in the pathogenesis of Alzheimer\u2019s disease: cellular and subcellular alterations in underpinning a tale of two. Neuromol Med 27(1):35","journal-title":"Neuromol Med"},{"key":"4799_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107776","author":"J Chen","year":"2025","unstructured":"Chen J, Fei S, Chan LWC, Gan X, Shao B, Jiang H, Li S, Kuang P, Liu X, Yang S (2025) Inflammatory signaling pathways in pancreatic \u03b2-cell: new insights into Type 2 Diabetes pathogenesis. Pharmacol Res. https:\/\/doi.org\/10.1016\/j.phrs.2025.107776","journal-title":"Pharmacol Res"},{"key":"4799_CR38","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.113538","volume":"171","author":"I Poto\u010dnjak","year":"2023","unstructured":"Poto\u010dnjak I, \u0160imi\u0107 L, Bati\u010di\u0107 L, Kri\u017ean H, Domitrovi\u0107 R (2023) Sinomenine mitigates cisplatin-induced kidney injury by targeting multiple signaling pathways. Food Chem Toxicol 171:113538","journal-title":"Food Chem Toxicol"},{"key":"4799_CR39","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.peptides.2017.02.004","volume":"90","author":"SSF Rahiman","year":"2017","unstructured":"Rahiman SSF, Morgan M, Gray P, Shaw PN, Cabot PJ (2017) Inhibitory effects of dynorphin 3\u201314 on the lipopolysaccharide-induced toll-like receptor 4 signalling pathway. Peptides 90:48\u201354","journal-title":"Peptides"},{"key":"4799_CR40","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/3013716","volume":"2019","author":"JN Zhang","year":"2019","unstructured":"Zhang JN, Ma Y, Wei XY, Liu KY, Wang H, Han H, Cui Y, Zhang MX, Qin WD (2019) Remifentanil protects against lipopolysaccharide-induced inflammation through PARP-1\/NF-\u03baB signaling pathway. Mediators Inflamm 2019:3013716","journal-title":"Mediators Inflamm"},{"key":"4799_CR41","doi-asserted-by":"publisher","DOI":"10.3390\/bios12070500","author":"D Oprea","year":"2022","unstructured":"Oprea D, Sanz CG, Barsan MM, Enache TA (2022) PC-12 cell line as a neuronal cell model for biosensing applications. Biosensors. https:\/\/doi.org\/10.3390\/bios12070500","journal-title":"Biosensors"},{"key":"4799_CR42","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25020772","author":"K Tominami","year":"2024","unstructured":"Tominami K, Kudo TA, Noguchi T, Hayashi Y, Luo YR, Tanaka T, Matsushita A, Izumi S, Sato H, Gengyo-Ando K, Matsuzawa A, Hong G, Nakai J (2024) Physical stimulation methods developed for in vitro neuronal differentiation studies of PC12 cells: a comprehensive review. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms25020772","journal-title":"Int J Mol Sci"},{"key":"4799_CR43","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.freeradbiomed.2023.08.026","volume":"208","author":"B Xu","year":"2023","unstructured":"Xu B, Zhou Z, Fang J, Wang J, Tao K, Liu J, Liu S (2023) Exosomes derived from Schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy. Free Radic Biol Med 208:319\u2013333","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"4799_CR44","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02248-2","volume":"18","author":"Y Hou","year":"2021","unstructured":"Hou Y, Luan J, Huang T, Deng T, Li X, Xiao Z, Zhan J, Luo D, Hou Y, Xu L, Lin D (2021) Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response. J Neuroinflammation 18(1):216","journal-title":"J Neuroinflammation"},{"issue":"1","key":"4799_CR45","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-024-01784-1","volume":"12","author":"BC Plug","year":"2024","unstructured":"Plug BC, Revers IM, Breur M, Gonz\u00e1lez GM, Timmerman JA, Meijns NRC, Hamberg D, Wagendorp J, Nutma E, Wolf NI, Luchicchi A, Mansvelder HD, van Til NP, van der Knaap MS, Bugiani M (2024) Human post-mortem organotypic brain slice cultures: a tool to study pathomechanisms and test therapies. Acta Neuropathol Commun 12(1):83","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"4799_CR46","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13024-022-00585-1","volume":"17","author":"B Khalil","year":"2022","unstructured":"Khalil B, Chhangani D, Wren MC, Smith CL, Lee JH, Li X, Puttinger C, Tsai CW, Fortin G, Morderer D, Gao J, Liu F, Lim CK, Chen J, Chou CC, Croft CL, Gleixner AM, Donnelly CJ, Golde TE, Petrucelli L, Oskarsson B, Dickson DW, Zhang K, Shorter J, Yoshimura SH, Barmada SJ, Rincon-Limas DE, Rossoll W (2022) Nuclear import receptors are recruited by FG-nucleoporins to rescue hallmarks of TDP-43 proteinopathy. Mol Neurodegener 17(1):80","journal-title":"Mol Neurodegener"},{"key":"4799_CR47","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2020.592005","volume":"14","author":"ARD Delbridge","year":"2020","unstructured":"Delbridge ARD, Huh D, Brickelmaier M, Burns JC, Roberts C, Challa R, Raymond N, Cullen P, Carlile TM, Ennis KA, Liu M, Sun C, Allaire NE, Foos M, Tsai HH, Franchimont N, Ransohoff RM, Butts C, Mingueneau M (2020) Organotypic brain slice culture microglia exhibit molecular similarity to acutely-isolated adult microglia and provide a platform to study neuroinflammation. Front Cell Neurosci 14:592005","journal-title":"Front Cell Neurosci"},{"key":"4799_CR48","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.102211","volume":"34","author":"CM Walsh","year":"2025","unstructured":"Walsh CM, Hill S, Newland B, Dooley D (2025) Cryogel scaffolds for localised delivery of lipopolysaccharide in organotypic spinal cord slice cultures: a novel ex vivo model of neuroinflammation. Mater Today Bio 34:102211","journal-title":"Mater Today Bio"},{"key":"4799_CR49","doi-asserted-by":"publisher","unstructured":"Wiatrak B, Kubis-Kubiak A, Piwowar A, Barg E (2020) PC12 cell line: cell types, coating of culture vessels, differentiation and other culture conditions. Cells. https:\/\/doi.org\/10.3390\/cells9040958","DOI":"10.3390\/cells9040958"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-026-04799-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-026-04799-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-026-04799-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T17:02:35Z","timestamp":1782752555000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s11064-026-04799-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["4799"],"URL":"https:\/\/doi.org\/10.1007\/s11064-026-04799-3","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"9 September 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"180"}}