{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:32:08Z","timestamp":1793460728994,"version":"4.5.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Brain Science and Brain-like Intelligence Technology - National Science and Technology Major Project","award":["2021ZD0204403"],"award-info":[{"award-number":["2021ZD0204403"]}]},{"name":"National Natural Science Foundation of China","award":["82130034"],"award-info":[{"award-number":["82130034"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Neurochem Res"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s11064-026-04870-z","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:48:55Z","timestamp":1787640535000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glutamatergic Projection from the Ventrolateral Periaqueductal Gray to the Parafascicular Nucleus of the Thalamus Contributes to the Modulation of Neuropathic Pain in Mice"],"prefix":"10.1007","volume":"51","author":[{"given":"Dong-Ning","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2166-7137","authenticated-orcid":false,"given":"Yao-Hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Min","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Ang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong-Yi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha-Sha","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Yu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Qi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen-Sheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7413-7702","authenticated-orcid":false,"given":"Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3707-3348","authenticated-orcid":false,"given":"Yun-Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"issue":"9","key":"4870_CR1","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1097\/j.pain.0000000000001939","volume":"161","author":"SN Raja","year":"2020","unstructured":"Raja SN, Carr DB, Cohen M et al (2020) The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. Pain 161(9):1976\u20131982","journal-title":"Pain"},{"issue":"4","key":"4870_CR2","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.cnc.2017.08.002","volume":"29","author":"PM Orr","year":"2017","unstructured":"Orr PM, Shank BC, Black AC (2017) The role of pain classification systems in pain management. Crit Care Nurs Clin North Am 29(4):407\u2013418","journal-title":"Crit Care Nurs Clin North Am"},{"key":"4870_CR3","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1038\/nn942","volume":"5 Suppl","author":"J Scholz","year":"2002","unstructured":"Scholz J, Woolf CJ (2002) Can we conquer pain? Nat Neurosci 5 Suppl:1062\u20131067","journal-title":"Nat Neurosci"},{"issue":"5","key":"4870_CR4","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.neuron.2019.02.019","volume":"101","author":"I Tracey","year":"2019","unstructured":"Tracey I, Woolf CJ, Andrews NA (2019) Composite pain biomarker signatures for objective assessment and effective treatment. Neuron 101(5):783\u2013800","journal-title":"Neuron"},{"issue":"3","key":"4870_CR5","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/j.immuni.2019.08.014","volume":"51","author":"N Limjunyawong","year":"2019","unstructured":"Limjunyawong N, Dong X (2019) Spicy immunity: pain to gain. Immunity 51(3):426\u2013428","journal-title":"Immunity"},{"issue":"2","key":"4870_CR6","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cell.2009.09.028","volume":"139","author":"AI Basbaum","year":"2009","unstructured":"Basbaum AI, Bautista DM, Scherrer G et al (2009) Cellular and molecular mechanisms of pain. Cell 139(2):267\u2013284","journal-title":"Cell"},{"issue":"23","key":"4870_CR7","doi-asserted-by":"publisher","first-page":"4631","DOI":"10.1016\/j.cub.2020.09.008","volume":"30","author":"G Chung","year":"2020","unstructured":"Chung G, Shim HG, Kim CY et al (2020) Persistent activity of metabotropic glutamate receptor 5 in the periaqueductal gray constrains emergence of chronic neuropathic pain. Curr Biol 30(23):4631\u20134642e6","journal-title":"Curr Biol"},{"issue":"6","key":"4870_CR8","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1080\/01616412.2020.1747730","volume":"42","author":"M Hosseini","year":"2020","unstructured":"Hosseini M, Parviz M, Shabanzadeh AP et al (2020) The inhibiting role of periaqueductal gray metabotropic glutamate receptor subtype 8 in a rat model of central neuropathic pain. Neurol Res 42(6):515\u2013521","journal-title":"Neurol Res"},{"issue":"12","key":"4870_CR9","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1016\/j.jpain.2013.08.003","volume":"14","author":"ML Mehalick","year":"2013","unstructured":"Mehalick ML, Ingram SL, Aicher SA et al (2013) Chronic inflammatory pain prevents tolerance to the antinociceptive effect of morphine microinjected into the ventrolateral periaqueductal gray of the rat. J Pain 14(12):1601\u20131610","journal-title":"J Pain"},{"key":"4870_CR10","doi-asserted-by":"publisher","first-page":"106699","DOI":"10.1016\/j.nbd.2024.106699","volume":"202","author":"D Li","year":"2024","unstructured":"Li D, Mai JW, Deng J et al (2024) A neural circuit from thalamic paraventricular nucleus via zona incerta to periaqueductal gray for the facilitation of neuropathic pain. Neurobiol Dis 202:106699","journal-title":"Neurobiol Dis"},{"issue":"12","key":"4870_CR11","doi-asserted-by":"publisher","first-page":"6555","DOI":"10.1172\/JCI127607","volume":"130","author":"JB Yin","year":"2020","unstructured":"Yin JB, Liang SH, Li F et al (2020) dmPFC-vlPAG projection neurons contribute to pain threshold maintenance and antianxiety behaviors. J Clin Invest 130(12):6555\u20136570","journal-title":"J Clin Invest"},{"key":"4870_CR12","doi-asserted-by":"crossref","unstructured":"Samineni VK, Grajales-Reyes JG, Copits BA et al (2017) Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray. eNeuro, 4(2)","DOI":"10.1523\/ENEURO.0129-16.2017"},{"issue":"1","key":"4870_CR13","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1002\/1096-9861(20000814)424:1<111::AID-CNE9>3.0.CO;2-3","volume":"424","author":"KE Krout","year":"2000","unstructured":"Krout KE, Loewy AD (2000) Periaqueductal gray matter projections to midline and intralaminar thalamic nuclei of the rat. Comp Neurol 424(1):111\u2013141","journal-title":"Comp Neurol"},{"issue":"5","key":"4870_CR14","doi-asserted-by":"publisher","first-page":"640","DOI":"10.3340\/jkns.2022.0004","volume":"65","author":"M Chung","year":"2022","unstructured":"Chung M, Huh R (2022) Neuromodulation for trigeminal neuralgia. J Korean Neurosurg Soc 65(5):640\u2013651","journal-title":"J Korean Neurosurg Soc"},{"key":"4870_CR15","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.neuroscience.2019.04.050","volume":"410","author":"JN Li","year":"2019","unstructured":"Li JN, Sun Y, Ji SL et al (2019) Collateral Projections from the medullary dorsal horn to the ventral posteromedial thalamic nucleus and the parafascicular thalamic nucleus in the rat. Neuroscience 410:293\u2013304","journal-title":"Neuroscience"},{"issue":"4","key":"4870_CR16","doi-asserted-by":"publisher","first-page":"106332","DOI":"10.1016\/j.isci.2023.106332","volume":"26","author":"T Ishikawa","year":"2023","unstructured":"Ishikawa T, Murata K, Okuda H et al (2023) Pain-related neuronal ensembles in the primary somatosensory cortex contribute to hyperalgesia and anxiety. iScience 26(4):106332","journal-title":"iScience"},{"issue":"12","key":"4870_CR17","doi-asserted-by":"publisher","first-page":"3847","DOI":"10.1016\/j.celrep.2019.11.003","volume":"29","author":"X Zhu","year":"2019","unstructured":"Zhu X, Zhou W, Jin Y et al (2019) A central amygdala input to the parafascicular nucleus controls comorbid pain in depression. Cell Rep 29(12):3847\u20133858","journal-title":"Cell Rep"},{"key":"4870_CR18","doi-asserted-by":"crossref","unstructured":"Wu FL, Chen SH, Li JN et al (2023) Projections from the rostral zona incerta to the thalamic paraventricular nucleus mediate nociceptive neurotransmission in mice. Metabolites, 13(2):226","DOI":"10.3390\/metabo13020226"},{"key":"4870_CR19","unstructured":"Paxinos G, Franklin KBJ (2007) The Mouse Brain in Stereotaxic Coordinates[M]. 3rd edition, San Diego: Academic Press"},{"issue":"1","key":"4870_CR20","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1038\/s41467-023-38264-4","volume":"14","author":"JN Li","year":"2023","unstructured":"Li JN, Wu XM, Zhao LJ et al (2023) Central medial thalamic nucleus dynamically participates in acute itch sensation and chronic itch-induced anxiety-like behavior in male mice. Nat Commun 14(1):2539","journal-title":"Nat Commun"},{"issue":"41","key":"4870_CR21","doi-asserted-by":"publisher","first-page":"7837","DOI":"10.1523\/JNEUROSCI.2487-19.2020","volume":"40","author":"SH Liang","year":"2020","unstructured":"Liang SH, Zhao WJ, Yin JB et al (2020) A neural circuit from thalamic paraventricular nucleus to central amygdala for the facilitation of neuropathic pain. J Neurosci 40(41):7837\u20137854","journal-title":"J Neurosci"},{"key":"4870_CR22","doi-asserted-by":"publisher","first-page":"105640","DOI":"10.1016\/j.neuint.2023.105640","volume":"171","author":"J Hong","year":"2023","unstructured":"Hong J, Li JN, Wu FL et al (2023) Projections from anteromedial thalamus nucleus to the midcingulate cortex mediate pain and anxiety-like behaviors in mice. Neurochem Int 171:105640","journal-title":"Neurochem Int"},{"issue":"6","key":"4870_CR23","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1152\/jn.00251.2021","volume":"126","author":"D Pati","year":"2021","unstructured":"Pati D, Kash TL (2021) Tumor necrosis factor-alpha modulates GABAergic and dopaminergic neurons in the ventrolateral periaqueductal gray of female mice. J Neurophysiol 126(6):2119\u20132129","journal-title":"J Neurophysiol"},{"issue":"8","key":"4870_CR24","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1016\/j.neuron.2021.03.001","volume":"109","author":"W Yu","year":"2021","unstructured":"Yu W, Pati D, Pina MM et al (2021) Periaqueductal gray\/dorsal raphe dopamine neurons contribute to sex differences in pain-related behaviors. Neuron 109(8):1365\u20131380","journal-title":"Neuron"},{"issue":"1\u20132","key":"4870_CR25","first-page":"11","volume":"122","author":"AF Bourquin","year":"2006","unstructured":"Bourquin AF, Suveges M, Pertin M et al (2006) Assessment and analysis of mechanical allodynia-like behavior induced by spared nerve injury (SNI) in the mouse. Pain 122(1\u20132):11\u201314","journal-title":"Pain"},{"issue":"4","key":"4870_CR26","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/s41593-021-00811-x","volume":"24","author":"X Zhu","year":"2021","unstructured":"Zhu X, Tang HD, Zhang Z et al (2021) Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states. Nat Neurosci 24(4):542\u2013553","journal-title":"Nat Neurosci"},{"key":"4870_CR27","doi-asserted-by":"publisher","first-page":"107107","DOI":"10.1016\/j.nbd.2025.107107","volume":"216","author":"F Li","year":"2025","unstructured":"Li F, Li Z-A, Li J et al (2025) Projection from the parafascicular nucleus of the thalamus to the insular cortex mediate analgesia and anti-anxiety behaviors in mice. Neurobiol Dis 216:107107","journal-title":"Neurobiol Dis"},{"key":"4870_CR28","doi-asserted-by":"crossref","unstructured":"Zhu X, Zhang C, Hu Y et al (2024) Modulation of comorbid chronic neuropathic pain and anxiety-like behaviors by glutamatergic neurons in the ventrolateral periaqueductal gray and the analgesic and anxiolytic effects of electroacupuncture. eNeuro, 11(8)","DOI":"10.1523\/ENEURO.0454-23.2024"},{"key":"4870_CR29","doi-asserted-by":"crossref","unstructured":"Faull OK, Pattinson KT (2017) The cortical connectivity of the periaqueductal gray and the conditioned response to the threat of breathlessness. Elife, 6:e21749","DOI":"10.7554\/eLife.21749"},{"issue":"2","key":"4870_CR30","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.neulet.2003.10.011","volume":"354","author":"JM Farook","year":"2004","unstructured":"Farook JM, Wang Q, Moochhala SM et al (2004) Distinct regions of periaqueductal gray (PAG) are involved in freezing behavior in hooded PVG rats on the cat-freezing test apparatus. Neurosci Lett 354(2):139\u2013142","journal-title":"Neurosci Lett"}],"container-title":["Neurochemical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-026-04870-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-026-04870-z","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s11064-026-04870-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T15:10:47Z","timestamp":1793459447000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s11064-026-04870-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["4870"],"URL":"https:\/\/doi.org\/10.1007\/s11064-026-04870-z","relation":{},"ISSN":["0364-3190","1573-6903"],"issn-type":[{"value":"0364-3190","type":"print"},{"value":"1573-6903","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"assertion":[{"value":"28 January 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2026","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2026","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2026","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The authors declare no competing interests.","order":1,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"246"}}